locus-tag	class	description
HBSAL_RS00015	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HBSAL_RS00055	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HBSAL_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HBSAL_RS00070	COG2873	o-acetylhomoserine
HBSAL_RS00075	COG0277	FAD linked oxidase domain protein
HBSAL_RS00080	COG0560	Phosphoserine phosphatase
HBSAL_RS00085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HBSAL_RS00100	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HBSAL_RS00120	COG0165	Argininosuccinate lyase
HBSAL_RS00125	COG0137	argininosuccinate synthase activity
HBSAL_RS00210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HBSAL_RS00245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HBSAL_RS00250	COG0822	iron-sulfur transferase activity
HBSAL_RS00265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HBSAL_RS00290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HBSAL_RS00295	COG0581	inorganic phosphate transmembrane transporter activity
HBSAL_RS00300	COG0573	inorganic phosphate transmembrane transporter activity
HBSAL_RS00310	COG0702	epimerase
HBSAL_RS00350	COG0519	Catalyzes the synthesis of GMP from XMP
HBSAL_RS00350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HBSAL_RS00355	COG1078	dGTPase activity
HBSAL_RS00370	COG0167	dihydroorotate dehydrogenase activity
HBSAL_RS00440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HBSAL_RS00445	COG0434	BtpA family
HBSAL_RS00465	COG0456	acetyltransferase
HBSAL_RS00490	COG0747	negative chemotaxis
HBSAL_RS00495	COG0601	transmembrane transport
HBSAL_RS00500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HBSAL_RS00510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HBSAL_RS00530	COG1335	isochorismatase
HBSAL_RS00555	COG2309	aminopeptidase activity
HBSAL_RS00570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HBSAL_RS00575	COG1120	ATPase activity
HBSAL_RS00580	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HBSAL_RS00590	COG0633	Ferredoxin
HBSAL_RS00605	COG1120	ATPase activity
HBSAL_RS00610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HBSAL_RS00665	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HBSAL_RS00700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HBSAL_RS00715	COG0778	Nitroreductase
HBSAL_RS00715	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HBSAL_RS00720	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HBSAL_RS00740	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HBSAL_RS00750	COG0140	phosphoribosyl-ATP diphosphatase activity
HBSAL_RS00760	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HBSAL_RS00775	COG0471	metal ion transport
HBSAL_RS00775	COG3273	potassium ion transport
HBSAL_RS00785	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HBSAL_RS00790	COG0351	phosphomethylpyrimidine kinase
HBSAL_RS00800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HBSAL_RS00815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HBSAL_RS00840	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HBSAL_RS00845	COG1063	alcohol dehydrogenase
HBSAL_RS00850	COG0210	DNA helicase
HBSAL_RS00870	COG2339	peptidase activity
HBSAL_RS00910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HBSAL_RS00970	COG0557	exoribonuclease II activity
HBSAL_RS00980	COG0051	transcription antitermination factor activity, RNA binding
HBSAL_RS00985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HBSAL_RS00990	COG0460	homoserine dehydrogenase
HBSAL_RS01000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HBSAL_RS01010	COG0049	tRNA binding
HBSAL_RS01025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HBSAL_RS01030	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HBSAL_RS01035	COG0085	RNA polymerase activity
HBSAL_RS01065	COG1309	transcriptional regulator
HBSAL_RS01090	COG1136	(ABC) transporter
HBSAL_RS01090	COG0577	efflux transmembrane transporter activity
HBSAL_RS01095	COG0577	efflux transmembrane transporter activity
HBSAL_RS01095	COG1136	(ABC) transporter
HBSAL_RS01105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HBSAL_RS01110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HBSAL_RS01115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HBSAL_RS01285	COG0438	transferase activity, transferring glycosyl groups
HBSAL_RS01295	COG1132	(ABC) transporter
HBSAL_RS01305	COG3385	transposase activity
HBSAL_RS01315	COG0438	transferase activity, transferring glycosyl groups
HBSAL_RS01325	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HBSAL_RS01330	COG0673	inositol 2-dehydrogenase activity
HBSAL_RS01335	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HBSAL_RS01340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HBSAL_RS01360	COG0314	molybdopterin synthase activity
HBSAL_RS01365	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HBSAL_RS01370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HBSAL_RS01380	COG0303	'Molybdopterin
HBSAL_RS01385	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HBSAL_RS01425	COG1278	Cold shock
HBSAL_RS01430	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HBSAL_RS01435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HBSAL_RS01470	COG4221	oxidoreductase activity
HBSAL_RS01485	COG1132	(ABC) transporter
HBSAL_RS01505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HBSAL_RS01600	COG0864	Transcriptional regulator
HBSAL_RS01635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBSAL_RS01655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HBSAL_RS01670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HBSAL_RS01675	COG0318	PFAM AMP-dependent synthetase and ligase
HBSAL_RS01680	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HBSAL_RS01705	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HBSAL_RS01715	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HBSAL_RS01720	COG0531	amino acid
HBSAL_RS01760	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HBSAL_RS01765	COG1073	alpha beta
HBSAL_RS01765	COG2226	methyltransferase
HBSAL_RS01785	COG1078	dGTPase activity
HBSAL_RS01790	COG0037	tRNA processing
HBSAL_RS01790	COG0590	tRNA wobble adenosine to inosine editing
HBSAL_RS01795	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HBSAL_RS01880	COG0714	Associated with various cellular activities
HBSAL_RS01890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HBSAL_RS01965	COG0717	Belongs to the dCTP deaminase family
HBSAL_RS01995	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HBSAL_RS02020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HBSAL_RS02035	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HBSAL_RS02060	COG1215	transferase activity, transferring glycosyl groups
HBSAL_RS02075	COG1233	COG1233 Phytoene dehydrogenase and related
HBSAL_RS02115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HBSAL_RS02125	COG2226	methyltransferase
HBSAL_RS02140	COG2860	membrane
HBSAL_RS02165	COG0134	indole-3-glycerol-phosphate synthase activity
HBSAL_RS02170	COG0133	tryptophan synthase activity
HBSAL_RS02175	COG0159	tryptophan synthase activity
HBSAL_RS02180	COG1830	Aldolase
HBSAL_RS02190	COG1465	3-dehydroquinate synthase
HBSAL_RS02245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HBSAL_RS02245	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HBSAL_RS02250	COG0076	glutamate decarboxylase activity
HBSAL_RS02255	COG0501	Belongs to the peptidase M48B family
HBSAL_RS02260	COG0574	Belongs to the PEP-utilizing enzyme family
HBSAL_RS02260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HBSAL_RS02270	COG0384	phenazine biosynthesis protein PhzF
HBSAL_RS02280	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HBSAL_RS02295	COG1196	nuclear chromosome segregation
HBSAL_RS02305	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HBSAL_RS02340	COG0840	transmembrane signaling receptor activity
HBSAL_RS02365	COG1515	deoxyribonuclease V activity
HBSAL_RS02370	COG1028	Short-chain dehydrogenase reductase Sdr
HBSAL_RS02375	COG0003	Pfam Anion-transporting ATPase
HBSAL_RS02385	COG1058	Belongs to the CinA family
HBSAL_RS02385	COG1546	Belongs to the CinA family
HBSAL_RS02400	COG1960	acyl-CoA dehydrogenase activity
HBSAL_RS02425	COG1234	tRNA 3'-trailer cleavage
HBSAL_RS02435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HBSAL_RS02445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HBSAL_RS02450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HBSAL_RS02450	COG0512	Glutamine amidotransferase of anthranilate synthase
HBSAL_RS02470	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HBSAL_RS02495	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HBSAL_RS02505	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HBSAL_RS02510	COG0442	prolyl-tRNA aminoacylation
HBSAL_RS02525	COG0371	Dehydrogenase
HBSAL_RS02540	COG1505	serine-type exopeptidase activity
HBSAL_RS02550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HBSAL_RS02555	COG0138	bifunctional purine biosynthesis protein purh
HBSAL_RS02580	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HBSAL_RS02585	COG2124	cytochrome p450
HBSAL_RS02605	COG0477	Major facilitator Superfamily
HBSAL_RS02610	COG1024	Enoyl-CoA hydratase
HBSAL_RS02630	COG0051	transcription antitermination factor activity, RNA binding
HBSAL_RS02645	COG1473	amidohydrolase
HBSAL_RS02650	COG0445	tRNA wobble uridine modification
HBSAL_RS02660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HBSAL_RS02660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HBSAL_RS02670	COG4948	Mandelate Racemase Muconate Lactonizing
HBSAL_RS02675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HBSAL_RS02690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HBSAL_RS02695	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HBSAL_RS02700	COG0704	Plays a role in the regulation of phosphate uptake
HBSAL_RS02705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HBSAL_RS02710	COG0573	inorganic phosphate transmembrane transporter activity
HBSAL_RS02715	COG0573	inorganic phosphate transmembrane transporter activity
HBSAL_RS02735	COG0017	Asparaginyl-tRNA synthetase
HBSAL_RS02750	COG1131	(ABC) transporter
HBSAL_RS02760	COG0656	L-ascorbic acid biosynthetic process
HBSAL_RS02780	COG1476	TRANSCRIPTIONal
HBSAL_RS02790	COG1013	pyruvate-flavodoxin oxidoreductase activity
HBSAL_RS02795	COG0674	pyruvate-flavodoxin oxidoreductase activity
HBSAL_RS02795	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HBSAL_RS02805	COG1051	belongs to the nudix hydrolase family
HBSAL_RS02810	COG0346	lactoylglutathione lyase activity
HBSAL_RS02815	COG1028	Short-chain dehydrogenase reductase Sdr
HBSAL_RS02820	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HBSAL_RS02820	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HBSAL_RS02835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HBSAL_RS02860	COG0484	heat shock protein binding
HBSAL_RS02865	COG0443	Heat shock 70 kDa protein
HBSAL_RS02875	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HBSAL_RS02900	COG2814	Major facilitator Superfamily
HBSAL_RS02905	COG0436	Aminotransferase
HBSAL_RS02920	COG1253	flavin adenine dinucleotide binding
HBSAL_RS02940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HBSAL_RS02955	COG0419	ATPase involved in DNA repair
HBSAL_RS02985	COG4221	oxidoreductase activity
HBSAL_RS02990	COG0396	ATPase activity
HBSAL_RS02995	COG0719	Fe-S assembly protein
HBSAL_RS03000	COG0719	Fe-S assembly protein
HBSAL_RS03040	COG1321	iron dependent repressor
HBSAL_RS03055	COG2358	TRAP transporter, solute receptor (TAXI family
HBSAL_RS03065	COG1233	COG1233 Phytoene dehydrogenase and related
HBSAL_RS03075	COG0484	heat shock protein binding
HBSAL_RS03090	COG1098	S1 RNA binding domain
HBSAL_RS03135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HBSAL_RS03140	COG0651	ATP synthesis coupled electron transport
HBSAL_RS03145	COG0651	ATP synthesis coupled electron transport
HBSAL_RS03150	COG0651	ATP synthesis coupled electron transport
HBSAL_RS03155	COG1006	Multisubunit Na H antiporter MnhC subunit
HBSAL_RS03170	COG1320	monovalent cation:proton antiporter activity
HBSAL_RS03175	COG2212	antiporter activity
HBSAL_RS03180	COG1863	multisubunit Na H antiporter MnhE subunit
HBSAL_RS03185	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HBSAL_RS03205	COG2234	aminopeptidase activity
HBSAL_RS03230	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HBSAL_RS03235	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HBSAL_RS03270	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HBSAL_RS03290	COG0346	lactoylglutathione lyase activity
HBSAL_RS03305	COG0438	transferase activity, transferring glycosyl groups
HBSAL_RS03310	COG0438	transferase activity, transferring glycosyl groups
HBSAL_RS03340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HBSAL_RS03345	COG1832	CoA-binding protein
HBSAL_RS03400	COG0616	signal peptide processing
HBSAL_RS03410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HBSAL_RS03420	COG2030	dehydratase
HBSAL_RS03425	COG2301	Belongs to the HpcH HpaI aldolase family
HBSAL_RS03430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HBSAL_RS03440	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HBSAL_RS03450	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HBSAL_RS03460	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HBSAL_RS03465	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HBSAL_RS03470	COG0649	NAD binding
HBSAL_RS03470	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HBSAL_RS03475	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HBSAL_RS03480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HBSAL_RS03505	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HBSAL_RS03510	COG1007	ATP synthesis coupled electron transport
HBSAL_RS03515	COG1227	inorganic diphosphatase activity
HBSAL_RS03520	COG2239	Acts as a magnesium transporter
HBSAL_RS03530	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HBSAL_RS03530	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HBSAL_RS03570	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HBSAL_RS03575	COG0109	protoheme IX farnesyltransferase activity
HBSAL_RS03585	COG1131	(ABC) transporter
HBSAL_RS03605	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HBSAL_RS03605	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HBSAL_RS03615	COG2267	carboxylic ester hydrolase activity
HBSAL_RS03635	COG1960	acyl-CoA dehydrogenase activity
HBSAL_RS03645	COG1250	3-hydroxyacyl-CoA dehydrogenase
HBSAL_RS03655	COG1830	Aldolase
HBSAL_RS03660	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HBSAL_RS03675	COG4555	ABC transporter
HBSAL_RS03705	COG2217	Heavy metal translocating P-type atpase
HBSAL_RS03725	COG3046	protein related to deoxyribodipyrimidine photolyase
HBSAL_RS03740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HBSAL_RS03755	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HBSAL_RS03770	COG0561	phosphatase activity
HBSAL_RS03780	COG0534	Mate efflux family protein
HBSAL_RS03805	COG0534	Mate efflux family protein
HBSAL_RS03825	COG0430	RNA-3'-phosphate cyclase activity
HBSAL_RS03840	COG0745	RESPONSE REGULATOR receiver
HBSAL_RS03845	COG0642	Histidine kinase
HBSAL_RS03885	COG2718	Belongs to the UPF0229 family
HBSAL_RS03895	COG2766	serine protein kinase
HBSAL_RS03910	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HBSAL_RS03945	COG1546	Belongs to the CinA family
HBSAL_RS03945	COG1058	Belongs to the CinA family
HBSAL_RS03950	COG0671	phosphoesterase, PA-phosphatase related
HBSAL_RS03995	COG1960	acyl-CoA dehydrogenase activity
HBSAL_RS04000	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HBSAL_RS04000	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HBSAL_RS04030	COG3794	PFAM blue (type 1) copper domain protein
HBSAL_RS04060	COG0840	transmembrane signaling receptor activity
HBSAL_RS04075	COG0626	cystathionine gamma-synthase activity
HBSAL_RS04085	COG1136	(ABC) transporter
HBSAL_RS04100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HBSAL_RS04110	COG0840	transmembrane signaling receptor activity
HBSAL_RS04110	COG3290	protein histidine kinase activity
HBSAL_RS04115	COG1012	belongs to the aldehyde dehydrogenase family
HBSAL_RS04130	COG0840	transmembrane signaling receptor activity
HBSAL_RS04140	COG0702	epimerase
HBSAL_RS04145	COG2130	NADP-dependent
HBSAL_RS04160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HBSAL_RS04185	COG0746	molybdenum cofactor guanylyltransferase activity
HBSAL_RS04205	COG0243	molybdopterin cofactor binding
HBSAL_RS04275	COG0154	amidase activity
HBSAL_RS04340	COG3385	transposase activity
HBSAL_RS04350	COG2205	protein histidine kinase activity
HBSAL_RS04380	COG1074	ATP-dependent DNA helicase activity
HBSAL_RS04440	COG1192	Involved in chromosome partitioning
HBSAL_RS04490	COG3385	transposase activity
HBSAL_RS04525	COG1304	FMN binding
HBSAL_RS04540	COG1192	Involved in chromosome partitioning
HBSAL_RS04560	COG3385	transposase activity
HBSAL_RS04665	COG2226	methyltransferase
HBSAL_RS04695	COG0640	Transcriptional regulator
HBSAL_RS04840	COG0864	Transcriptional regulator
HBSAL_RS04875	COG0306	phosphate transporter
HBSAL_RS04890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HBSAL_RS04890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HBSAL_RS04895	COG0425	Belongs to the sulfur carrier protein TusA family
HBSAL_RS04900	COG2210	Belongs to the sulfur carrier protein TusA family
HBSAL_RS04915	COG2226	methyltransferase
HBSAL_RS04950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HBSAL_RS05055	COG0437	4 iron, 4 sulfur cluster binding
HBSAL_RS05145	COG3679	Belongs to the UPF0342 family
HBSAL_RS05155	COG2890	protein-(glutamine-N5) methyltransferase activity
HBSAL_RS05170	COG0107	imidazoleglycerol-phosphate synthase activity
HBSAL_RS05180	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HBSAL_RS05185	COG0587	DNA-directed DNA polymerase activity
HBSAL_RS05205	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HBSAL_RS05210	COG0154	amidase activity
HBSAL_RS05215	COG1607	acyl-coa hydrolase
HBSAL_RS05230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HBSAL_RS05250	COG1793	dna ligase
HBSAL_RS05255	COG0647	UMP catabolic process
HBSAL_RS05275	COG0187	DNA topoisomerase II activity
HBSAL_RS05280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HBSAL_RS05290	COG1252	NADH dehydrogenase
HBSAL_RS05295	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HBSAL_RS05300	COG0813	purine-nucleoside phosphorylase activity
HBSAL_RS05310	COG1079	Belongs to the binding-protein-dependent transport system permease family
HBSAL_RS05315	COG4603	Belongs to the binding-protein-dependent transport system permease family
HBSAL_RS05320	COG3845	ABC transporter
HBSAL_RS05325	COG1744	ABC transporter substrate-binding protein PnrA-like
HBSAL_RS05330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HBSAL_RS05340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HBSAL_RS05365	COG3844	kynureninase activity
HBSAL_RS05370	COG4191	Histidine kinase
HBSAL_RS05375	COG0745	RESPONSE REGULATOR receiver
HBSAL_RS05400	COG3842	ATPase activity
HBSAL_RS05430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HBSAL_RS05470	COG0778	Nitroreductase
HBSAL_RS05480	COG1012	belongs to the aldehyde dehydrogenase family
HBSAL_RS05495	COG0857	belongs to the CobB CobQ family
HBSAL_RS05515	COG2894	cell division
HBSAL_RS05530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HBSAL_RS05600	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HBSAL_RS05615	COG0643	Histidine kinase
HBSAL_RS05615	COG2198	Histidine kinase
HBSAL_RS05620	COG2201	protein-glutamate methylesterase activity
HBSAL_RS05625	COG2201	protein-glutamate methylesterase activity
HBSAL_RS05690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HBSAL_RS05695	COG0667	Aldo Keto reductase
HBSAL_RS05715	COG0517	IMP dehydrogenase activity
HBSAL_RS05715	COG0516	GMP reductase activity
HBSAL_RS05790	COG0129	dihydroxy-acid dehydratase activity
HBSAL_RS05795	COG0473	3-isopropylmalate dehydrogenase activity
HBSAL_RS05800	COG0066	3-isopropylmalate dehydratase activity
HBSAL_RS05805	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HBSAL_RS05815	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HBSAL_RS05870	COG1690	Belongs to the RtcB family
HBSAL_RS05875	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HBSAL_RS05900	COG1213	nucleotidyl transferase
HBSAL_RS05900	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HBSAL_RS05910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HBSAL_RS05950	COG0179	Fumarylacetoacetate (FAA) hydrolase
HBSAL_RS05955	COG0667	Aldo Keto reductase
HBSAL_RS05960	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HBSAL_RS05985	COG2337	Toxic component of a toxin-antitoxin (TA) module
HBSAL_RS06035	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HBSAL_RS06045	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HBSAL_RS06060	COG3385	transposase activity
HBSAL_RS06075	COG0463	Glycosyl transferase, family 2
HBSAL_RS06075	COG1216	Glycosyl transferase, family 2
HBSAL_RS06080	COG0438	transferase activity, transferring glycosyl groups
HBSAL_RS06095	COG1216	Glycosyl transferase, family 2
HBSAL_RS06095	COG0463	Glycosyl transferase, family 2
HBSAL_RS06135	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HBSAL_RS06145	COG0318	PFAM AMP-dependent synthetase and ligase
HBSAL_RS06150	COG1441	menaquinone biosynthetic process
HBSAL_RS06155	COG1575	Belongs to the MenA family. Type 1 subfamily
HBSAL_RS06165	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HBSAL_RS06170	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HBSAL_RS06205	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HBSAL_RS06245	COG0215	cysteine-tRNA ligase activity
HBSAL_RS06260	COG1335	isochorismatase
HBSAL_RS06280	COG0081	regulation of translation
HBSAL_RS06285	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HBSAL_RS06295	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HBSAL_RS06305	COG0346	lactoylglutathione lyase activity
HBSAL_RS06320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HBSAL_RS06340	COG0436	Aminotransferase
HBSAL_RS06350	COG1013	pyruvate-flavodoxin oxidoreductase activity
HBSAL_RS06355	COG0674	pyruvate-flavodoxin oxidoreductase activity
HBSAL_RS06355	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HBSAL_RS06365	COG0489	protein tyrosine kinase activity
HBSAL_RS06375	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HBSAL_RS06385	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HBSAL_RS06410	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HBSAL_RS06425	COG0148	phosphopyruvate hydratase activity
HBSAL_RS06430	COG0052	Belongs to the universal ribosomal protein uS2 family
HBSAL_RS06440	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HBSAL_RS06450	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HBSAL_RS06465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HBSAL_RS06495	COG0105	UTP biosynthetic process
HBSAL_RS06505	COG2890	protein-(glutamine-N5) methyltransferase activity
HBSAL_RS06515	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HBSAL_RS06540	COG0626	cystathionine gamma-synthase activity
HBSAL_RS06580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HBSAL_RS06595	COG0535	radical SAM domain protein
HBSAL_RS06605	COG0535	radical SAM domain protein
HBSAL_RS06630	COG1960	acyl-CoA dehydrogenase activity
HBSAL_RS06665	COG0644	oxidoreductase
HBSAL_RS06680	COG1011	Hydrolase
HBSAL_RS06685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HBSAL_RS06690	COG0402	S-adenosylhomocysteine deaminase activity
HBSAL_RS06710	COG0010	Belongs to the arginase family
HBSAL_RS06715	COG1228	amidohydrolase
HBSAL_RS06720	COG2986	histidine ammonia-lyase
HBSAL_RS06740	COG0126	phosphoglycerate kinase activity
HBSAL_RS06750	COG0572	uridine kinase
HBSAL_RS06790	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HBSAL_RS06795	COG0516	GMP reductase activity
HBSAL_RS06800	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HBSAL_RS06825	COG1522	sequence-specific DNA binding
HBSAL_RS06835	COG0531	amino acid
HBSAL_RS06840	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HBSAL_RS06850	COG1605	Chorismate mutase
HBSAL_RS06850	COG0287	Prephenate dehydrogenase
HBSAL_RS06865	COG1131	(ABC) transporter
HBSAL_RS06880	COG1201	RNA secondary structure unwinding
HBSAL_RS06910	COG0492	ferredoxin-NADP+ reductase activity
HBSAL_RS06970	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HBSAL_RS06970	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HBSAL_RS06975	COG0315	cyclic pyranopterin monophosphate synthase activity
HBSAL_RS06985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HBSAL_RS07000	COG2890	protein-(glutamine-N5) methyltransferase activity
HBSAL_RS07020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HBSAL_RS07045	COG1047	Peptidyl-prolyl cis-trans
HBSAL_RS07060	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
HBSAL_RS07065	COG0301	tRNA thio-modification
HBSAL_RS07065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HBSAL_RS07075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HBSAL_RS07085	COG1331	Highly conserved protein containing a thioredoxin domain
HBSAL_RS07090	COG0151	Belongs to the GarS family
HBSAL_RS07095	COG1053	succinate dehydrogenase
HBSAL_RS07100	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HBSAL_RS07120	COG1024	Enoyl-CoA hydratase
HBSAL_RS07185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HBSAL_RS07200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HBSAL_RS07205	COG0415	Belongs to the DNA photolyase family
HBSAL_RS07220	COG0318	PFAM AMP-dependent synthetase and ligase
HBSAL_RS07235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HBSAL_RS07245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HBSAL_RS07255	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HBSAL_RS07265	COG0697	spore germination
HBSAL_RS07270	COG1522	sequence-specific DNA binding
HBSAL_RS07275	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HBSAL_RS07290	COG0114	fumarate hydratase activity
HBSAL_RS07295	COG0271	Belongs to the BolA IbaG family
HBSAL_RS07335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HBSAL_RS07340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HBSAL_RS07345	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HBSAL_RS07355	COG4191	Histidine kinase
HBSAL_RS07360	COG2205	protein histidine kinase activity
HBSAL_RS07365	COG1522	sequence-specific DNA binding
HBSAL_RS07370	COG0483	inositol monophosphate 1-phosphatase activity
HBSAL_RS07405	COG0110	maltose O-acetyltransferase activity
HBSAL_RS07450	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HBSAL_RS07485	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HBSAL_RS07500	COG0737	Belongs to the 5'-nucleotidase family
HBSAL_RS07525	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HBSAL_RS07530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HBSAL_RS07575	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HBSAL_RS07625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HBSAL_RS07645	COG0737	Belongs to the 5'-nucleotidase family
HBSAL_RS07680	COG0456	acetyltransferase
HBSAL_RS07700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HBSAL_RS07710	COG2202	Pas domain
HBSAL_RS07710	COG3920	Histidine kinase
HBSAL_RS07740	COG0632	four-way junction helicase activity
HBSAL_RS07775	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HBSAL_RS07790	COG1045	serine acetyltransferase
HBSAL_RS07795	COG1960	acyl-CoA dehydrogenase activity
HBSAL_RS07835	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HBSAL_RS07850	COG1363	Peptidase, m42
HBSAL_RS07870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HBSAL_RS07875	COG1234	tRNA 3'-trailer cleavage
HBSAL_RS07915	COG1435	thymidine kinase activity
HBSAL_RS07930	COG1194	a g-specific adenine glycosylase
HBSAL_RS07945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HBSAL_RS07950	COG1285	pathogenesis
HBSAL_RS07955	COG0733	neurotransmitter:sodium symporter activity
HBSAL_RS07960	COG0733	neurotransmitter:sodium symporter activity
HBSAL_RS07965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HBSAL_RS07975	COG4770	biotin carboxylase activity
HBSAL_RS07985	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HBSAL_RS07985	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HBSAL_RS07990	COG0589	response to stress
HBSAL_RS07995	COG1078	dGTPase activity
HBSAL_RS08010	COG0045	succinate-CoA ligase (ADP-forming) activity
HBSAL_RS08015	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HBSAL_RS08025	COG0038	chloride channel
HBSAL_RS08035	COG2096	Adenosyltransferase
HBSAL_RS08075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HBSAL_RS08075	COG1648	precorrin-2 dehydrogenase activity
HBSAL_RS08095	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HBSAL_RS08110	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HBSAL_RS08135	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HBSAL_RS08150	COG1492	cobalamin metabolic process
HBSAL_RS08165	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HBSAL_RS08175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HBSAL_RS08220	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HBSAL_RS08225	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HBSAL_RS08230	COG0509	glycine decarboxylation via glycine cleavage system
HBSAL_RS08235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HBSAL_RS08275	COG0655	NAD(P)H dehydrogenase (quinone) activity
HBSAL_RS08300	COG2255	four-way junction helicase activity
HBSAL_RS08310	COG0281	malic enzyme
HBSAL_RS08310	COG0280	phosphate acetyltransferase
HBSAL_RS08325	COG0667	Aldo Keto reductase
HBSAL_RS08335	COG1122	ATPase activity
HBSAL_RS08345	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
HBSAL_RS08385	COG0512	Glutamine amidotransferase of anthranilate synthase
HBSAL_RS08385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HBSAL_RS08390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HBSAL_RS08395	COG0135	phosphoribosylanthranilate isomerase activity
HBSAL_RS08400	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HBSAL_RS08420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HBSAL_RS08440	COG0589	response to stress
HBSAL_RS08475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HBSAL_RS08495	COG0284	orotidine-5'-phosphate decarboxylase activity
HBSAL_RS08500	COG0484	heat shock protein binding
HBSAL_RS08510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HBSAL_RS08535	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HBSAL_RS08540	COG1233	COG1233 Phytoene dehydrogenase and related
HBSAL_RS08545	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
HBSAL_RS08615	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HBSAL_RS08620	COG0088	Forms part of the polypeptide exit tunnel
HBSAL_RS08630	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HBSAL_RS08635	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HBSAL_RS08645	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HBSAL_RS08650	COG0255	Belongs to the universal ribosomal protein uL29 family
HBSAL_RS08660	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HBSAL_RS08665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HBSAL_RS08690	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HBSAL_RS08695	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HBSAL_RS08700	COG0322	excinuclease ABC activity
HBSAL_RS08715	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HBSAL_RS08755	COG0563	adenylate kinase activity
HBSAL_RS08765	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HBSAL_RS08770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HBSAL_RS08830	COG3361	conserved protein (COG2071)
HBSAL_RS08840	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HBSAL_RS08855	COG0415	Belongs to the DNA photolyase family
HBSAL_RS08900	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HBSAL_RS08905	COG0010	Belongs to the arginase family
HBSAL_RS08920	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HBSAL_RS08935	COG2154	pterin-4-alpha-carbinolamine dehydratase
HBSAL_RS08940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HBSAL_RS08945	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HBSAL_RS08945	COG1648	precorrin-2 dehydrogenase activity
HBSAL_RS08960	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HBSAL_RS08965	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HBSAL_RS08970	COG1836	PFAM Integral membrane protein DUF92
HBSAL_RS08975	COG0358	DNA primase activity
HBSAL_RS09015	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HBSAL_RS09025	COG0083	homoserine kinase activity
HBSAL_RS09105	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HBSAL_RS09120	COG0604	alcohol dehydrogenase
HBSAL_RS09125	COG0521	Mo-molybdopterin cofactor biosynthetic process
HBSAL_RS09145	COG0519	Catalyzes the synthesis of GMP from XMP
HBSAL_RS09145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HBSAL_RS09150	COG0504	CTP synthase activity
HBSAL_RS09170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HBSAL_RS09210	COG0252	asparaginase activity
HBSAL_RS09255	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HBSAL_RS09260	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HBSAL_RS09285	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HBSAL_RS09300	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HBSAL_RS09305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HBSAL_RS09335	COG1176	ABC-type spermidine putrescine transport system, permease component I
HBSAL_RS09345	COG3842	ATPase activity
HBSAL_RS09385	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HBSAL_RS09390	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HBSAL_RS09410	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HBSAL_RS09460	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HBSAL_RS09465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HBSAL_RS09515	COG1522	sequence-specific DNA binding
HBSAL_RS09520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HBSAL_RS09525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HBSAL_RS09545	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HBSAL_RS09555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HBSAL_RS09590	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HBSAL_RS09615	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HBSAL_RS09620	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HBSAL_RS09625	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HBSAL_RS09645	COG0047	phosphoribosylformylglycinamidine synthase activity
HBSAL_RS09655	COG0788	formyltetrahydrofolate deformylase activity
HBSAL_RS09725	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HBSAL_RS09730	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HBSAL_RS09735	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HBSAL_RS09740	COG0247	lactate metabolic process
HBSAL_RS09790	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HBSAL_RS09795	COG1757	Na H antiporter
HBSAL_RS09810	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HBSAL_RS09825	COG0166	Belongs to the GPI family
HBSAL_RS09845	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HBSAL_RS09860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HBSAL_RS09865	COG1164	Oligoendopeptidase f
HBSAL_RS09875	COG0101	tRNA pseudouridine synthase activity
HBSAL_RS09880	COG0124	histidyl-tRNA synthetase
HBSAL_RS09900	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HBSAL_RS09915	COG0528	UMP kinase activity
HBSAL_RS09930	COG1695	Transcriptional regulator
HBSAL_RS09935	COG3253	May function as heme-dependent peroxidase
HBSAL_RS09940	COG0667	Aldo Keto reductase
HBSAL_RS09975	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HBSAL_RS09980	COG1024	Enoyl-CoA hydratase
HBSAL_RS10000	COG0745	RESPONSE REGULATOR receiver
HBSAL_RS10005	COG2205	protein histidine kinase activity
HBSAL_RS10020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HBSAL_RS10030	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HBSAL_RS10055	COG1185	polyribonucleotide nucleotidyltransferase activity
HBSAL_RS10080	COG0464	growth
HBSAL_RS10090	COG0183	Belongs to the thiolase family
HBSAL_RS10110	COG1022	Amp-dependent synthetase and ligase
HBSAL_RS10120	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HBSAL_RS10165	COG1573	uracil-dna glycosylase
HBSAL_RS10175	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HBSAL_RS10185	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HBSAL_RS10195	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
HBSAL_RS10220	COG0459	protein refolding
HBSAL_RS10225	COG2311	Membrane
HBSAL_RS10240	COG0251	oxidation-reduction process
HBSAL_RS10245	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HBSAL_RS10255	COG0372	Belongs to the citrate synthase family
HBSAL_RS10275	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HBSAL_RS10305	COG2252	PERMEase
HBSAL_RS10310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HBSAL_RS10315	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HBSAL_RS10335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HBSAL_RS10340	COG1757	Na H antiporter
HBSAL_RS10345	COG1757	Na H antiporter
HBSAL_RS10350	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HBSAL_RS10360	COG0731	radical SAM domain protein
HBSAL_RS10375	COG0484	heat shock protein binding
HBSAL_RS10430	COG1269	ATP hydrolysis coupled proton transport
HBSAL_RS10465	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HBSAL_RS10475	COG0142	geranyltranstransferase activity
HBSAL_RS10505	COG0662	Cupin 2, conserved barrel domain protein
HBSAL_RS10505	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HBSAL_RS10525	COG0442	prolyl-tRNA aminoacylation
HBSAL_RS10640	COG0537	adenosine 5'-monophosphoramidase activity
HBSAL_RS10655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HBSAL_RS10665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HBSAL_RS10715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HBSAL_RS10745	COG0534	Mate efflux family protein
HBSAL_RS10750	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HBSAL_RS10780	COG0495	leucyl-tRNA aminoacylation
HBSAL_RS10790	COG0459	protein refolding
HBSAL_RS10795	COG1185	polyribonucleotide nucleotidyltransferase activity
HBSAL_RS10835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HBSAL_RS10850	COG1234	tRNA 3'-trailer cleavage
HBSAL_RS10865	COG0116	Belongs to the methyltransferase superfamily
HBSAL_RS10865	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HBSAL_RS10885	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HBSAL_RS10895	COG0402	S-adenosylhomocysteine deaminase activity
HBSAL_RS10900	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HBSAL_RS10920	COG0688	phosphatidylethanolamine metabolic process
HBSAL_RS10935	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
HBSAL_RS10955	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HBSAL_RS10970	COG0805	protein transport
HBSAL_RS10975	COG0805	protein transport
HBSAL_RS10990	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HBSAL_RS11000	COG2827	Endonuclease containing a URI domain
HBSAL_RS11005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HBSAL_RS11025	COG0435	Glutathione S-transferase
HBSAL_RS11035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HBSAL_RS11040	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HBSAL_RS11050	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HBSAL_RS11055	COG4865	methylaspartate mutase activity
HBSAL_RS11060	COG3799	methylaspartate ammonia-lyase activity
HBSAL_RS11070	COG0427	acetyl-CoA hydrolase
HBSAL_RS11080	COG0633	Ferredoxin
HBSAL_RS11085	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HBSAL_RS11090	COG0131	Imidazoleglycerol-phosphate dehydratase
HBSAL_RS11110	COG1739	Uncharacterized protein family UPF0029
HBSAL_RS11120	COG0492	ferredoxin-NADP+ reductase activity
HBSAL_RS11125	COG4946	Tricorn protease homolog
HBSAL_RS11125	COG1506	peptidase
HBSAL_RS11125	COG0823	Involved in the tonB-independent uptake of proteins
HBSAL_RS11135	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HBSAL_RS11150	COG1253	flavin adenine dinucleotide binding
HBSAL_RS11165	COG0009	L-threonylcarbamoyladenylate synthase
HBSAL_RS11190	COG1268	BioY protein
HBSAL_RS11195	COG1122	ATPase activity
HBSAL_RS11205	COG0247	lactate metabolic process
HBSAL_RS11205	COG2181	nitrate reductase activity
HBSAL_RS11220	COG0113	porphobilinogen synthase activity
HBSAL_RS11230	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HBSAL_RS11245	COG0181	hydroxymethylbilane synthase activity
HBSAL_RS11250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HBSAL_RS11265	COG3852	Histidine kinase
HBSAL_RS11305	COG4608	Belongs to the ABC transporter superfamily
HBSAL_RS11310	COG0444	Belongs to the ABC transporter superfamily
HBSAL_RS11315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HBSAL_RS11320	COG0601	transmembrane transport
HBSAL_RS11330	COG0617	tRNA 3'-terminal CCA addition
HBSAL_RS11330	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HBSAL_RS11330	COG0517	IMP dehydrogenase activity
HBSAL_RS11335	COG0423	glycine-tRNA ligase activity
HBSAL_RS11345	COG0556	nucleotide-excision repair
HBSAL_RS11355	COG0601	transmembrane transport
HBSAL_RS11360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HBSAL_RS11370	COG4608	Belongs to the ABC transporter superfamily
HBSAL_RS11380	COG0039	L-malate dehydrogenase activity
HBSAL_RS11450	COG0322	excinuclease ABC activity
HBSAL_RS11455	COG0556	nucleotide-excision repair
HBSAL_RS11480	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HBSAL_RS11485	COG3842	ATPase activity
HBSAL_RS11490	COG2226	methyltransferase
HBSAL_RS11510	COG0534	Mate efflux family protein
HBSAL_RS11535	COG0864	Transcriptional regulator
HBSAL_RS11555	COG0071	Belongs to the small heat shock protein (HSP20) family
HBSAL_RS11615	COG0569	domain protein
HBSAL_RS11620	COG0531	amino acid
HBSAL_RS11745	COG0095	Lipoate-protein ligase
HBSAL_RS11750	COG0402	S-adenosylhomocysteine deaminase activity
HBSAL_RS11760	COG0733	neurotransmitter:sodium symporter activity
HBSAL_RS11765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HBSAL_RS11770	COG1121	(ABC) transporter
HBSAL_RS11785	COG1297	OPT oligopeptide transporter protein
HBSAL_RS11820	COG0395	ABC-type sugar transport system, permease component
HBSAL_RS11825	COG3842	ATPase activity
HBSAL_RS11850	COG0864	Transcriptional regulator
HBSAL_RS11875	COG0697	spore germination
HBSAL_RS11880	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HBSAL_RS11885	COG2267	carboxylic ester hydrolase activity
HBSAL_RS11905	COG1785	Belongs to the alkaline phosphatase family
HBSAL_RS11910	COG1253	flavin adenine dinucleotide binding
HBSAL_RS11915	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HBSAL_RS11920	COG0602	queuosine metabolic process
HBSAL_RS11930	COG1301	dicarboxylic acid transport
HBSAL_RS11935	COG0540	Belongs to the ATCase OTCase family
HBSAL_RS11940	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HBSAL_RS11945	COG0018	arginyl-trna synthetase
HBSAL_RS11950	COG1757	Na H antiporter
HBSAL_RS11955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HBSAL_RS11970	COG1414	Transcriptional regulator
HBSAL_RS12070	COG3385	transposase activity
HBSAL_RS12075	COG0419	ATPase involved in DNA repair
HBSAL_RS12080	COG0420	3'-5' exonuclease activity
HBSAL_RS12135	COG1271	oxidase subunit
HBSAL_RS12215	COG3385	transposase activity
HBSAL_RS12270	COG3385	transposase activity
HBSAL_RS12420	COG3385	transposase activity
HBSAL_RS12440	COG0542	response to heat
HBSAL_RS12450	COG1192	Involved in chromosome partitioning
HBSAL_RS12495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HBSAL_RS12495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HBSAL_RS12550	COG3385	transposase activity
HBSAL_RS12555	COG0419	ATPase involved in DNA repair
HBSAL_RS12560	COG0420	3'-5' exonuclease activity
HBSAL_RS12615	COG1271	oxidase subunit
HBSAL_RS12695	COG3385	transposase activity