locus-tag	class	description
HALDL1_RS00040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HALDL1_RS00045	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HALDL1_RS00055	COG2873	o-acetylhomoserine
HALDL1_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HALDL1_RS00065	COG2873	o-acetylhomoserine
HALDL1_RS00085	COG0560	Phosphoserine phosphatase
HALDL1_RS00100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HALDL1_RS00115	COG5002	protein histidine kinase activity
HALDL1_RS00120	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HALDL1_RS00140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HALDL1_RS00145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HALDL1_RS00150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HALDL1_RS00155	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HALDL1_RS00160	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HALDL1_RS00165	COG0189	ligase activity
HALDL1_RS00175	COG0165	Argininosuccinate lyase
HALDL1_RS00180	COG0137	argininosuccinate synthase activity
HALDL1_RS00290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HALDL1_RS00290	COG0596	Alpha beta hydrolase
HALDL1_RS00290	COG2226	methyltransferase
HALDL1_RS00310	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HALDL1_RS00325	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HALDL1_RS00330	COG0822	iron-sulfur transferase activity
HALDL1_RS00355	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HALDL1_RS00365	COG3422	double-strand break repair
HALDL1_RS00370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HALDL1_RS00385	COG0704	Plays a role in the regulation of phosphate uptake
HALDL1_RS00395	COG0581	inorganic phosphate transmembrane transporter activity
HALDL1_RS00400	COG0573	inorganic phosphate transmembrane transporter activity
HALDL1_RS00410	COG0702	epimerase
HALDL1_RS00455	COG0519	Catalyzes the synthesis of GMP from XMP
HALDL1_RS00455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HALDL1_RS00460	COG1078	dGTPase activity
HALDL1_RS00480	COG0435	Glutathione S-transferase
HALDL1_RS00485	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HALDL1_RS00515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HALDL1_RS00520	COG0431	NADPH-dependent FMN reductase
HALDL1_RS00525	COG2827	Endonuclease containing a URI domain
HALDL1_RS00535	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HALDL1_RS00555	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HALDL1_RS00565	COG0805	protein transport
HALDL1_RS00570	COG0805	protein transport
HALDL1_RS00630	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HALDL1_RS00635	COG4191	Histidine kinase
HALDL1_RS00665	COG1418	mRNA catabolic process
HALDL1_RS00670	COG0688	phosphatidylethanolamine metabolic process
HALDL1_RS00700	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HALDL1_RS00710	COG0402	S-adenosylhomocysteine deaminase activity
HALDL1_RS00715	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HALDL1_RS00735	COG0116	Belongs to the methyltransferase superfamily
HALDL1_RS00735	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HALDL1_RS00755	COG1234	tRNA 3'-trailer cleavage
HALDL1_RS00770	COG2311	Membrane
HALDL1_RS00775	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HALDL1_RS00815	COG0180	Tryptophanyl-tRNA synthetase
HALDL1_RS00845	COG0525	valine-tRNA ligase activity
HALDL1_RS00850	COG0071	Belongs to the small heat shock protein (HSP20) family
HALDL1_RS00855	COG0077	Prephenate dehydratase
HALDL1_RS00870	COG0022	dehydrogenase e1 component
HALDL1_RS00880	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HALDL1_RS00905	COG0628	permease
HALDL1_RS00935	COG0167	dihydroorotate dehydrogenase activity
HALDL1_RS01005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HALDL1_RS01020	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HALDL1_RS01045	COG0831	urea catabolic process
HALDL1_RS01045	COG0832	Belongs to the urease beta subunit family
HALDL1_RS01050	COG0804	urea catabolic process
HALDL1_RS01055	COG0831	urea catabolic process
HALDL1_RS01065	COG0829	nickel cation binding
HALDL1_RS01075	COG0830	nickel cation binding
HALDL1_RS01170	COG0456	acetyltransferase
HALDL1_RS01205	COG0747	negative chemotaxis
HALDL1_RS01210	COG0601	transmembrane transport
HALDL1_RS01215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALDL1_RS01225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HALDL1_RS01240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HALDL1_RS01240	COG2146	nitrite reductase [NAD(P)H] activity
HALDL1_RS01280	COG0525	valine-tRNA ligase activity
HALDL1_RS01290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HALDL1_RS01295	COG1120	ATPase activity
HALDL1_RS01305	COG1132	(ABC) transporter
HALDL1_RS01315	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HALDL1_RS01320	COG4977	sequence-specific DNA binding
HALDL1_RS01330	COG0534	Mate efflux family protein
HALDL1_RS01360	COG0598	Magnesium transport protein CorA
HALDL1_RS01365	COG0717	Belongs to the dCTP deaminase family
HALDL1_RS01410	COG1305	Transglutaminase-like
HALDL1_RS01420	COG0714	Associated with various cellular activities
HALDL1_RS01435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HALDL1_RS01440	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HALDL1_RS01440	COG0778	Nitroreductase
HALDL1_RS01450	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HALDL1_RS01465	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HALDL1_RS01480	COG0140	phosphoribosyl-ATP diphosphatase activity
HALDL1_RS01490	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HALDL1_RS01505	COG0471	metal ion transport
HALDL1_RS01505	COG3273	potassium ion transport
HALDL1_RS01535	COG0488	(ABC) transporter
HALDL1_RS01565	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HALDL1_RS01590	COG0210	DNA helicase
HALDL1_RS01615	COG2339	peptidase activity
HALDL1_RS01650	COG1028	Short-chain dehydrogenase reductase Sdr
HALDL1_RS01665	COG0657	acetylesterase activity
HALDL1_RS01675	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HALDL1_RS01695	COG0354	folic acid binding
HALDL1_RS01735	COG0557	exoribonuclease II activity
HALDL1_RS01750	COG0051	transcription antitermination factor activity, RNA binding
HALDL1_RS01755	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HALDL1_RS01760	COG0460	homoserine dehydrogenase
HALDL1_RS01770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HALDL1_RS01785	COG0049	tRNA binding
HALDL1_RS01800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HALDL1_RS01805	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HALDL1_RS01810	COG0085	RNA polymerase activity
HALDL1_RS01860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HALDL1_RS01865	COG2345	Transcriptional regulator
HALDL1_RS01880	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HALDL1_RS01910	COG1181	Belongs to the D-alanine--D-alanine ligase family
HALDL1_RS01925	COG0667	Aldo Keto reductase
HALDL1_RS01930	COG1278	Cold shock
HALDL1_RS01945	COG3119	arylsulfatase activity
HALDL1_RS02060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HALDL1_RS02120	COG1401	restriction endodeoxyribonuclease activity
HALDL1_RS02225	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HALDL1_RS02310	COG1522	sequence-specific DNA binding
HALDL1_RS02330	COG4608	Belongs to the ABC transporter superfamily
HALDL1_RS02335	COG0444	Belongs to the ABC transporter superfamily
HALDL1_RS02340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALDL1_RS02345	COG0601	transmembrane transport
HALDL1_RS02350	COG0747	negative chemotaxis
HALDL1_RS02385	COG1132	(ABC) transporter
HALDL1_RS02425	COG0501	Belongs to the peptidase M48B family
HALDL1_RS02665	COG3177	Filamentation induced by cAMP protein fic
HALDL1_RS02670	COG0154	amidase activity
HALDL1_RS02690	COG2217	Heavy metal translocating P-type atpase
HALDL1_RS02695	COG2217	Heavy metal translocating P-type atpase
HALDL1_RS02710	COG0747	negative chemotaxis
HALDL1_RS02720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALDL1_RS02725	COG0444	Belongs to the ABC transporter superfamily
HALDL1_RS02730	COG4608	Belongs to the ABC transporter superfamily
HALDL1_RS02760	COG2217	Heavy metal translocating P-type atpase
HALDL1_RS02770	COG0628	permease
HALDL1_RS02775	COG0446	pyridine nucleotide-disulphide oxidoreductase
HALDL1_RS02785	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HALDL1_RS02795	COG1984	allophanate hydrolase subunit 2
HALDL1_RS02810	COG3842	ATPase activity
HALDL1_RS02815	COG0439	Biotin carboxylase
HALDL1_RS02820	COG1522	sequence-specific DNA binding
HALDL1_RS02840	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HALDL1_RS02845	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HALDL1_RS02850	COG1122	ATPase activity
HALDL1_RS02875	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HALDL1_RS02905	COG0151	Belongs to the GarS family
HALDL1_RS02940	COG3361	conserved protein (COG2071)
HALDL1_RS02960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HALDL1_RS02970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HALDL1_RS02990	COG1028	Short-chain dehydrogenase reductase Sdr
HALDL1_RS02995	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HALDL1_RS03000	COG0022	dehydrogenase e1 component
HALDL1_RS03015	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HALDL1_RS03040	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HALDL1_RS03050	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HALDL1_RS03100	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HALDL1_RS03115	COG3842	ATPase activity
HALDL1_RS03145	COG0318	PFAM AMP-dependent synthetase and ligase
HALDL1_RS03150	COG1024	Enoyl-CoA hydratase
HALDL1_RS03155	COG2030	dehydratase
HALDL1_RS03160	COG0667	Aldo Keto reductase
HALDL1_RS03170	COG1960	acyl-CoA dehydrogenase activity
HALDL1_RS03180	COG0346	lactoylglutathione lyase activity
HALDL1_RS03195	COG1024	Enoyl-CoA hydratase
HALDL1_RS03210	COG1012	belongs to the aldehyde dehydrogenase family
HALDL1_RS03225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HALDL1_RS03230	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HALDL1_RS03230	COG0649	NAD binding
HALDL1_RS03240	COG1028	Short-chain dehydrogenase reductase Sdr
HALDL1_RS03250	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HALDL1_RS03260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HALDL1_RS03265	COG1253	flavin adenine dinucleotide binding
HALDL1_RS03280	COG0644	oxidoreductase
HALDL1_RS03285	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HALDL1_RS03315	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HALDL1_RS03325	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HALDL1_RS03330	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HALDL1_RS03340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HALDL1_RS03365	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HALDL1_RS03370	COG2226	methyltransferase
HALDL1_RS03400	COG1078	dGTPase activity
HALDL1_RS03410	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HALDL1_RS03480	COG5002	protein histidine kinase activity
HALDL1_RS03490	COG0489	protein tyrosine kinase activity
HALDL1_RS03530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HALDL1_RS03560	COG0714	Associated with various cellular activities
HALDL1_RS03570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HALDL1_RS03645	COG0519	Catalyzes the synthesis of GMP from XMP
HALDL1_RS03645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HALDL1_RS03690	COG0585	pseudouridine synthase activity
HALDL1_RS03705	COG0717	Belongs to the dCTP deaminase family
HALDL1_RS03730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HALDL1_RS03740	COG0017	Asparaginyl-tRNA synthetase
HALDL1_RS03745	COG4608	Belongs to the ABC transporter superfamily
HALDL1_RS03750	COG0444	Belongs to the ABC transporter superfamily
HALDL1_RS03760	COG0601	transmembrane transport
HALDL1_RS03765	COG0601	transmembrane transport
HALDL1_RS03785	COG0328	RNA-DNA hybrid ribonuclease activity
HALDL1_RS03800	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HALDL1_RS03815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HALDL1_RS03870	COG0667	Aldo Keto reductase
HALDL1_RS03880	COG1215	transferase activity, transferring glycosyl groups
HALDL1_RS03890	COG0494	nUDIX hydrolase
HALDL1_RS03935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HALDL1_RS03950	COG2226	methyltransferase
HALDL1_RS04000	COG0134	indole-3-glycerol-phosphate synthase activity
HALDL1_RS04005	COG0133	tryptophan synthase activity
HALDL1_RS04010	COG0159	tryptophan synthase activity
HALDL1_RS04015	COG1830	Aldolase
HALDL1_RS04020	COG1465	3-dehydroquinate synthase
HALDL1_RS04030	COG0710	3-dehydroquinate dehydratase activity
HALDL1_RS04045	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HALDL1_RS04050	COG0463	Glycosyl transferase, family 2
HALDL1_RS04085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HALDL1_RS04085	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HALDL1_RS04095	COG0076	glutamate decarboxylase activity
HALDL1_RS04105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HALDL1_RS04105	COG0574	Belongs to the PEP-utilizing enzyme family
HALDL1_RS04115	COG0384	phenazine biosynthesis protein PhzF
HALDL1_RS04130	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HALDL1_RS04145	COG1196	nuclear chromosome segregation
HALDL1_RS04155	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HALDL1_RS04205	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HALDL1_RS04205	COG1796	DNA polymerase
HALDL1_RS04220	COG1515	deoxyribonuclease V activity
HALDL1_RS04225	COG0300	oxidoreductase activity
HALDL1_RS04240	COG0003	Pfam Anion-transporting ATPase
HALDL1_RS04245	COG0436	Aminotransferase
HALDL1_RS04250	COG1058	Belongs to the CinA family
HALDL1_RS04250	COG1546	Belongs to the CinA family
HALDL1_RS04270	COG1960	acyl-CoA dehydrogenase activity
HALDL1_RS04295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HALDL1_RS04300	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HALDL1_RS04305	COG1234	tRNA 3'-trailer cleavage
HALDL1_RS04320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HALDL1_RS04325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HALDL1_RS04330	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HALDL1_RS04345	COG0492	ferredoxin-NADP+ reductase activity
HALDL1_RS04360	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HALDL1_RS04400	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HALDL1_RS04420	COG0442	prolyl-tRNA aminoacylation
HALDL1_RS04425	COG0069	glutamate synthase activity
HALDL1_RS04425	COG0070	glutamate synthase
HALDL1_RS04425	COG0067	glutamate synthase
HALDL1_RS04445	COG0371	Dehydrogenase
HALDL1_RS04455	COG0501	Belongs to the peptidase M48B family
HALDL1_RS04460	COG1505	serine-type exopeptidase activity
HALDL1_RS04485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HALDL1_RS04505	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HALDL1_RS04515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HALDL1_RS04520	COG0019	diaminopimelate decarboxylase activity
HALDL1_RS04525	COG2171	N-acyltransferase activity
HALDL1_RS04530	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HALDL1_RS04535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HALDL1_RS04565	COG2264	protein methyltransferase activity
HALDL1_RS04580	COG0477	Major facilitator Superfamily
HALDL1_RS04585	COG1024	Enoyl-CoA hydratase
HALDL1_RS04655	COG1473	amidohydrolase
HALDL1_RS04670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HALDL1_RS04670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HALDL1_RS04685	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HALDL1_RS04690	COG0704	Plays a role in the regulation of phosphate uptake
HALDL1_RS04695	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HALDL1_RS04700	COG0573	inorganic phosphate transmembrane transporter activity
HALDL1_RS04705	COG0573	inorganic phosphate transmembrane transporter activity
HALDL1_RS04710	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HALDL1_RS04725	COG0017	Asparaginyl-tRNA synthetase
HALDL1_RS04730	COG0656	L-ascorbic acid biosynthetic process
HALDL1_RS04735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HALDL1_RS04750	COG1013	pyruvate-flavodoxin oxidoreductase activity
HALDL1_RS04755	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HALDL1_RS04755	COG0674	pyruvate-flavodoxin oxidoreductase activity
HALDL1_RS04765	COG1051	belongs to the nudix hydrolase family
HALDL1_RS04770	COG0346	lactoylglutathione lyase activity
HALDL1_RS04780	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HALDL1_RS04780	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HALDL1_RS04810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HALDL1_RS04835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HALDL1_RS04845	COG0484	heat shock protein binding
HALDL1_RS04855	COG0443	Heat shock 70 kDa protein
HALDL1_RS04895	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HALDL1_RS04895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HALDL1_RS04905	COG0436	Aminotransferase
HALDL1_RS04930	COG0012	GTP binding
HALDL1_RS04935	COG1253	flavin adenine dinucleotide binding
HALDL1_RS04960	COG0247	lactate metabolic process
HALDL1_RS04960	COG0277	FAD linked oxidase domain protein
HALDL1_RS04980	COG0419	ATPase involved in DNA repair
HALDL1_RS05005	COG0396	ATPase activity
HALDL1_RS05010	COG0719	Fe-S assembly protein
HALDL1_RS05015	COG0719	Fe-S assembly protein
HALDL1_RS05060	COG1278	Cold shock
HALDL1_RS05080	COG2119	membrane
HALDL1_RS05085	COG1321	iron dependent repressor
HALDL1_RS05100	COG1233	COG1233 Phytoene dehydrogenase and related
HALDL1_RS05135	COG1098	S1 RNA binding domain
HALDL1_RS05180	COG2111	Na H antiporter
HALDL1_RS05180	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HALDL1_RS05185	COG2111	Na H antiporter
HALDL1_RS05190	COG1006	Multisubunit Na H antiporter MnhC subunit
HALDL1_RS05195	COG0651	ATP synthesis coupled electron transport
HALDL1_RS05200	COG1863	multisubunit Na H antiporter MnhE subunit
HALDL1_RS05205	COG2212	antiporter activity
HALDL1_RS05210	COG1320	monovalent cation:proton antiporter activity
HALDL1_RS05220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HALDL1_RS05225	COG0492	ferredoxin-NADP+ reductase activity
HALDL1_RS05240	COG1363	Peptidase, m42
HALDL1_RS05255	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HALDL1_RS05275	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HALDL1_RS05280	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HALDL1_RS05325	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HALDL1_RS05335	COG1252	NADH dehydrogenase
HALDL1_RS05350	COG0616	signal peptide processing
HALDL1_RS05365	COG0410	ABC transporter
HALDL1_RS05375	COG4177	L-phenylalanine transmembrane transporter activity
HALDL1_RS05380	COG0559	Belongs to the binding-protein-dependent transport system permease family
HALDL1_RS05395	COG0346	lactoylglutathione lyase activity
HALDL1_RS05400	COG0346	lactoylglutathione lyase activity
HALDL1_RS05435	COG0668	transmembrane transport
HALDL1_RS05450	COG2226	methyltransferase
HALDL1_RS05470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HALDL1_RS05475	COG1832	CoA-binding protein
HALDL1_RS05485	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HALDL1_RS05535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HALDL1_RS05550	COG2030	dehydratase
HALDL1_RS05565	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HALDL1_RS05580	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HALDL1_RS05590	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HALDL1_RS05600	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HALDL1_RS05605	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HALDL1_RS05610	COG0649	NAD binding
HALDL1_RS05610	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HALDL1_RS05620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HALDL1_RS05645	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HALDL1_RS05650	COG1007	ATP synthesis coupled electron transport
HALDL1_RS05655	COG1227	inorganic diphosphatase activity
HALDL1_RS05660	COG2239	Acts as a magnesium transporter
HALDL1_RS05670	COG4555	ABC transporter
HALDL1_RS05680	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HALDL1_RS05680	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HALDL1_RS05685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HALDL1_RS05700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HALDL1_RS05725	COG1845	cytochrome c oxidase, subunit III
HALDL1_RS05730	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HALDL1_RS05730	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HALDL1_RS05740	COG0109	protoheme IX farnesyltransferase activity
HALDL1_RS05740	COG1612	heme a metabolic process
HALDL1_RS05750	COG1131	(ABC) transporter
HALDL1_RS05765	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HALDL1_RS05765	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HALDL1_RS05785	COG0183	Belongs to the thiolase family
HALDL1_RS05805	COG1960	acyl-CoA dehydrogenase activity
HALDL1_RS05815	COG1250	3-hydroxyacyl-CoA dehydrogenase
HALDL1_RS05825	COG1830	Aldolase
HALDL1_RS05830	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HALDL1_RS05835	COG2135	peptidase activity
HALDL1_RS05845	COG0667	Aldo Keto reductase
HALDL1_RS05860	COG2217	Heavy metal translocating P-type atpase
HALDL1_RS05865	COG2608	mercury ion transmembrane transporter activity
HALDL1_RS05905	COG0668	transmembrane transport
HALDL1_RS05910	COG4122	O-methyltransferase activity
HALDL1_RS05935	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HALDL1_RS05960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HALDL1_RS05965	COG0644	oxidoreductase
HALDL1_RS05970	COG1902	pentaerythritol trinitrate reductase activity
HALDL1_RS05975	COG2226	methyltransferase
HALDL1_RS06000	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HALDL1_RS06010	COG1024	Enoyl-CoA hydratase
HALDL1_RS06015	COG1250	3-hydroxyacyl-CoA dehydrogenase
HALDL1_RS06025	COG0402	S-adenosylhomocysteine deaminase activity
HALDL1_RS06030	COG2814	Major facilitator Superfamily
HALDL1_RS06040	COG0183	Belongs to the thiolase family
HALDL1_RS06070	COG2855	membrane
HALDL1_RS06075	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HALDL1_RS06080	COG0010	Belongs to the arginase family
HALDL1_RS06085	COG1228	amidohydrolase
HALDL1_RS06090	COG2986	histidine ammonia-lyase
HALDL1_RS06100	COG1024	Enoyl-CoA hydratase
HALDL1_RS06150	COG3794	PFAM blue (type 1) copper domain protein
HALDL1_RS06160	COG0561	phosphatase activity
HALDL1_RS06175	COG2031	fatty acid transporter
HALDL1_RS06180	COG0154	amidase activity
HALDL1_RS06215	COG0579	oxidoreductase
HALDL1_RS06225	COG0586	Pfam SNARE associated Golgi protein
HALDL1_RS06230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HALDL1_RS06240	COG2813	Specifically methylates the guanine in position
HALDL1_RS06245	COG1131	(ABC) transporter
HALDL1_RS06250	COG0842	Transport permease protein
HALDL1_RS06265	COG0430	RNA-3'-phosphate cyclase activity
HALDL1_RS06285	COG4191	Histidine kinase
HALDL1_RS06315	COG1228	amidohydrolase
HALDL1_RS06345	COG2766	serine protein kinase
HALDL1_RS06410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HALDL1_RS06430	COG1546	Belongs to the CinA family
HALDL1_RS06430	COG1058	Belongs to the CinA family
HALDL1_RS06490	COG1940	carbohydrate kinase activity
HALDL1_RS06505	COG1960	acyl-CoA dehydrogenase activity
HALDL1_RS06510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HALDL1_RS06510	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HALDL1_RS06525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HALDL1_RS06600	COG1073	alpha beta
HALDL1_RS06605	COG0517	IMP dehydrogenase activity
HALDL1_RS06605	COG1125	glycine betaine transport
HALDL1_RS06610	COG0626	cystathionine gamma-synthase activity
HALDL1_RS06650	COG1295	ribonuclease BN
HALDL1_RS06660	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HALDL1_RS06665	COG1136	(ABC) transporter
HALDL1_RS06670	COG0577	efflux transmembrane transporter activity
HALDL1_RS06670	COG1136	(ABC) transporter
HALDL1_RS06675	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HALDL1_RS06715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HALDL1_RS06730	COG0840	transmembrane signaling receptor activity
HALDL1_RS06745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HALDL1_RS06765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HALDL1_RS06775	COG3845	ABC transporter
HALDL1_RS06780	COG4603	Belongs to the binding-protein-dependent transport system permease family
HALDL1_RS06785	COG1079	Belongs to the binding-protein-dependent transport system permease family
HALDL1_RS06810	COG1252	NADH dehydrogenase
HALDL1_RS06820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HALDL1_RS06830	COG0010	Belongs to the arginase family
HALDL1_RS06835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HALDL1_RS06840	COG0187	DNA topoisomerase II activity
HALDL1_RS06865	COG1793	dna ligase
HALDL1_RS06895	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HALDL1_RS06910	COG1607	acyl-coa hydrolase
HALDL1_RS06920	COG0154	amidase activity
HALDL1_RS06925	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HALDL1_RS06950	COG0490	domain, Protein
HALDL1_RS06955	COG0475	glutathione-regulated potassium exporter activity
HALDL1_RS06970	COG0587	DNA-directed DNA polymerase activity
HALDL1_RS06975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HALDL1_RS06985	COG0107	imidazoleglycerol-phosphate synthase activity
HALDL1_RS07005	COG2264	protein methyltransferase activity
HALDL1_RS07015	COG2197	response regulator
HALDL1_RS07065	COG2226	methyltransferase
HALDL1_RS07070	COG4974	Belongs to the 'phage' integrase family
HALDL1_RS07090	COG0725	ABC transporter, periplasmic molybdate-binding protein
HALDL1_RS07115	COG0657	acetylesterase activity
HALDL1_RS07120	COG3844	kynureninase activity
HALDL1_RS07160	COG3842	ATPase activity
HALDL1_RS07265	COG2894	cell division
HALDL1_RS07340	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HALDL1_RS07345	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HALDL1_RS07360	COG2198	Histidine kinase
HALDL1_RS07360	COG0643	Histidine kinase
HALDL1_RS07365	COG2201	protein-glutamate methylesterase activity
HALDL1_RS07370	COG2201	protein-glutamate methylesterase activity
HALDL1_RS07390	COG1111	helicase
HALDL1_RS07390	COG1205	dead DEAH box helicase
HALDL1_RS07430	COG1028	Short-chain dehydrogenase reductase Sdr
HALDL1_RS07485	COG0714	Associated with various cellular activities
HALDL1_RS07510	COG1305	Transglutaminase-like
HALDL1_RS07535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HALDL1_RS07605	COG3118	belongs to the thioredoxin family
HALDL1_RS07615	COG0730	response to heat
HALDL1_RS07640	COG0425	Belongs to the sulfur carrier protein TusA family
HALDL1_RS07645	COG2210	Belongs to the sulfur carrier protein TusA family
HALDL1_RS07655	COG1073	alpha beta
HALDL1_RS07655	COG2226	methyltransferase
HALDL1_RS07660	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HALDL1_RS07665	COG1960	acyl-CoA dehydrogenase activity
HALDL1_RS07695	COG0126	phosphoglycerate kinase activity
HALDL1_RS07705	COG0572	uridine kinase
HALDL1_RS07735	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HALDL1_RS07745	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HALDL1_RS07750	COG0006	proline dipeptidase activity
HALDL1_RS07790	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HALDL1_RS07830	COG1121	(ABC) transporter
HALDL1_RS07835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HALDL1_RS07845	COG1605	Chorismate mutase
HALDL1_RS07845	COG0287	Prephenate dehydrogenase
HALDL1_RS07895	COG1201	RNA secondary structure unwinding
HALDL1_RS07990	COG1254	Belongs to the acylphosphatase family
HALDL1_RS07995	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HALDL1_RS07995	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HALDL1_RS08000	COG0315	cyclic pyranopterin monophosphate synthase activity
HALDL1_RS08005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HALDL1_RS08020	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HALDL1_RS08030	COG2226	methyltransferase
HALDL1_RS08080	COG0540	Belongs to the ATCase OTCase family
HALDL1_RS08085	COG2894	cell division
HALDL1_RS08095	COG1047	Peptidyl-prolyl cis-trans
HALDL1_RS08110	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
HALDL1_RS08115	COG0301	tRNA thio-modification
HALDL1_RS08125	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HALDL1_RS08135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HALDL1_RS08140	COG1331	Highly conserved protein containing a thioredoxin domain
HALDL1_RS08145	COG0151	Belongs to the GarS family
HALDL1_RS08230	COG2988	succinylglutamate desuccinylase activity
HALDL1_RS08240	COG0668	transmembrane transport
HALDL1_RS08260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HALDL1_RS08280	COG0189	ligase activity
HALDL1_RS08280	COG0569	domain protein
HALDL1_RS08300	COG1250	3-hydroxyacyl-CoA dehydrogenase
HALDL1_RS08320	COG2030	dehydratase
HALDL1_RS08365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HALDL1_RS08380	COG0028	Belongs to the TPP enzyme family
HALDL1_RS08385	COG1012	belongs to the aldehyde dehydrogenase family
HALDL1_RS08395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HALDL1_RS08415	COG1058	Belongs to the CinA family
HALDL1_RS08415	COG1546	Belongs to the CinA family
HALDL1_RS08430	COG2255	four-way junction helicase activity
HALDL1_RS08450	COG1028	Short-chain dehydrogenase reductase Sdr
HALDL1_RS08480	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HALDL1_RS08485	COG1012	belongs to the aldehyde dehydrogenase family
HALDL1_RS08520	COG0277	FAD linked oxidase domain protein
HALDL1_RS08520	COG0247	lactate metabolic process
HALDL1_RS08535	COG1250	3-hydroxyacyl-CoA dehydrogenase
HALDL1_RS08550	COG0318	PFAM AMP-dependent synthetase and ligase
HALDL1_RS08585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HALDL1_RS08615	COG0415	Belongs to the DNA photolyase family
HALDL1_RS08625	COG0318	PFAM AMP-dependent synthetase and ligase
HALDL1_RS08630	COG1028	Short-chain dehydrogenase reductase Sdr
HALDL1_RS08635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HALDL1_RS08640	COG3321	synthase
HALDL1_RS08640	COG1028	Short-chain dehydrogenase reductase Sdr
HALDL1_RS08640	COG0604	alcohol dehydrogenase
HALDL1_RS08655	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HALDL1_RS08665	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HALDL1_RS08670	COG2030	dehydratase
HALDL1_RS08680	COG0697	spore germination
HALDL1_RS08690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HALDL1_RS08705	COG0114	fumarate hydratase activity
HALDL1_RS08770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HALDL1_RS08775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HALDL1_RS08780	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HALDL1_RS08790	COG1525	nuclease
HALDL1_RS08805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HALDL1_RS08820	COG0667	Aldo Keto reductase
HALDL1_RS08840	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HALDL1_RS08855	COG2226	methyltransferase
HALDL1_RS08860	COG0081	regulation of translation
HALDL1_RS08910	COG0071	Belongs to the small heat shock protein (HSP20) family
HALDL1_RS08930	COG0673	inositol 2-dehydrogenase activity
HALDL1_RS08970	COG0215	cysteine-tRNA ligase activity
HALDL1_RS09010	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HALDL1_RS09045	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HALDL1_RS09075	COG1575	Belongs to the MenA family. Type 1 subfamily
HALDL1_RS09080	COG4948	Mandelate Racemase Muconate Lactonizing
HALDL1_RS09085	COG0318	PFAM AMP-dependent synthetase and ligase
HALDL1_RS09100	COG1324	tolerance protein
HALDL1_RS09105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HALDL1_RS09125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HALDL1_RS09135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HALDL1_RS09165	COG0438	transferase activity, transferring glycosyl groups
HALDL1_RS09170	COG1216	Glycosyl transferase, family 2
HALDL1_RS09180	COG0500	methyltransferase
HALDL1_RS09200	COG0297	glycogen (starch) synthase activity
HALDL1_RS09205	COG1215	transferase activity, transferring glycosyl groups
HALDL1_RS09235	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HALDL1_RS09255	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HALDL1_RS09265	COG0179	Fumarylacetoacetate (FAA) hydrolase
HALDL1_RS09300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HALDL1_RS09310	COG1213	nucleotidyl transferase
HALDL1_RS09310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HALDL1_RS09335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HALDL1_RS09370	COG1960	acyl-CoA dehydrogenase activity
HALDL1_RS09380	COG0022	dehydrogenase e1 component
HALDL1_RS09390	COG0010	Belongs to the arginase family
HALDL1_RS09400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HALDL1_RS09405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HALDL1_RS09410	COG0006	proline dipeptidase activity
HALDL1_RS09425	COG0154	amidase activity
HALDL1_RS09430	COG1402	creatininase
HALDL1_RS09440	COG1028	Short-chain dehydrogenase reductase Sdr
HALDL1_RS09445	COG1028	Short-chain dehydrogenase reductase Sdr
HALDL1_RS09450	COG1012	belongs to the aldehyde dehydrogenase family
HALDL1_RS09455	COG1960	acyl-CoA dehydrogenase activity
HALDL1_RS09480	COG0516	GMP reductase activity
HALDL1_RS09480	COG0517	IMP dehydrogenase activity
HALDL1_RS09495	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HALDL1_RS09495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HALDL1_RS09505	COG1733	regulation of RNA biosynthetic process
HALDL1_RS09510	COG0346	lactoylglutathione lyase activity
HALDL1_RS09585	COG0402	S-adenosylhomocysteine deaminase activity
HALDL1_RS09610	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HALDL1_RS09640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HALDL1_RS09655	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HALDL1_RS09680	COG0492	ferredoxin-NADP+ reductase activity
HALDL1_RS09690	COG0436	Aminotransferase
HALDL1_RS09695	COG1522	sequence-specific DNA binding
HALDL1_RS09700	COG1013	pyruvate-flavodoxin oxidoreductase activity
HALDL1_RS09705	COG0674	pyruvate-flavodoxin oxidoreductase activity
HALDL1_RS09705	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HALDL1_RS09725	COG0489	protein tyrosine kinase activity
HALDL1_RS09740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HALDL1_RS09745	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HALDL1_RS09750	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HALDL1_RS09765	COG0200	Binds to the 23S rRNA
HALDL1_RS09775	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HALDL1_RS09790	COG0148	phosphopyruvate hydratase activity
HALDL1_RS09795	COG0052	Belongs to the universal ribosomal protein uS2 family
HALDL1_RS09810	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HALDL1_RS09815	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HALDL1_RS09830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HALDL1_RS09865	COG1444	tRNA N-acetyltransferase activity
HALDL1_RS09885	COG0105	UTP biosynthetic process
HALDL1_RS09900	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HALDL1_RS09910	COG2890	protein-(glutamine-N5) methyltransferase activity
HALDL1_RS09920	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HALDL1_RS09940	COG0626	cystathionine gamma-synthase activity
HALDL1_RS09975	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HALDL1_RS09985	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HALDL1_RS10010	COG0784	Response regulator, receiver
HALDL1_RS10040	COG0110	maltose O-acetyltransferase activity
HALDL1_RS10075	COG0471	metal ion transport
HALDL1_RS10075	COG3273	potassium ion transport
HALDL1_RS10085	COG0483	inositol monophosphate 1-phosphatase activity
HALDL1_RS10090	COG1522	sequence-specific DNA binding
HALDL1_RS10120	COG1435	thymidine kinase activity
HALDL1_RS10125	COG0431	NADPH-dependent FMN reductase
HALDL1_RS10160	COG2205	protein histidine kinase activity
HALDL1_RS10170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HALDL1_RS10175	COG1285	pathogenesis
HALDL1_RS10195	COG0372	Belongs to the citrate synthase family
HALDL1_RS10270	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HALDL1_RS10280	COG1201	RNA secondary structure unwinding
HALDL1_RS10325	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HALDL1_RS10345	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HALDL1_RS10355	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HALDL1_RS10375	COG1363	Peptidase, m42
HALDL1_RS10390	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HALDL1_RS10430	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HALDL1_RS10440	COG1045	serine acetyltransferase
HALDL1_RS10445	COG0546	phosphoglycolate phosphatase activity
HALDL1_RS10455	COG0596	Alpha beta hydrolase
HALDL1_RS10465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HALDL1_RS10545	COG0737	Belongs to the 5'-nucleotidase family
HALDL1_RS10560	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HALDL1_RS10585	COG3360	Dodecin
HALDL1_RS10595	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HALDL1_RS10610	COG1028	Short-chain dehydrogenase reductase Sdr
HALDL1_RS10660	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HALDL1_RS10675	COG1078	dGTPase activity
HALDL1_RS10685	COG0589	response to stress
HALDL1_RS10690	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HALDL1_RS10690	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HALDL1_RS10705	COG4770	biotin carboxylase activity
HALDL1_RS10710	COG2267	carboxylic ester hydrolase activity
HALDL1_RS10720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HALDL1_RS10725	COG0733	neurotransmitter:sodium symporter activity
HALDL1_RS10730	COG0733	neurotransmitter:sodium symporter activity
HALDL1_RS10750	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HALDL1_RS10760	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HALDL1_RS10805	COG0747	negative chemotaxis
HALDL1_RS10815	COG0601	transmembrane transport
HALDL1_RS10820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALDL1_RS10825	COG0444	Belongs to the ABC transporter superfamily
HALDL1_RS10830	COG4608	Belongs to the ABC transporter superfamily
HALDL1_RS10835	COG2267	carboxylic ester hydrolase activity
HALDL1_RS10840	COG0154	amidase activity
HALDL1_RS10850	COG2096	Adenosyltransferase
HALDL1_RS10860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HALDL1_RS10860	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HALDL1_RS10870	COG0864	Transcriptional regulator
HALDL1_RS10875	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HALDL1_RS10880	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HALDL1_RS10885	COG0509	glycine decarboxylation via glycine cleavage system
HALDL1_RS10890	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HALDL1_RS10940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HALDL1_RS10955	COG1295	ribonuclease BN
HALDL1_RS10985	COG0765	amino acid transport
HALDL1_RS11000	COG0280	phosphate acetyltransferase
HALDL1_RS11000	COG0281	malic enzyme
HALDL1_RS11010	COG0517	IMP dehydrogenase activity
HALDL1_RS11010	COG0617	tRNA 3'-terminal CCA addition
HALDL1_RS11010	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HALDL1_RS11020	COG0667	Aldo Keto reductase
HALDL1_RS11075	COG0512	Glutamine amidotransferase of anthranilate synthase
HALDL1_RS11075	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HALDL1_RS11080	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HALDL1_RS11085	COG0135	phosphoribosylanthranilate isomerase activity
HALDL1_RS11090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HALDL1_RS11135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HALDL1_RS11195	COG4251	negative regulation of phosphorylation
HALDL1_RS11210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HALDL1_RS11240	COG0284	orotidine-5'-phosphate decarboxylase activity
HALDL1_RS11245	COG0484	heat shock protein binding
HALDL1_RS11250	COG1011	Hydrolase
HALDL1_RS11255	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HALDL1_RS11285	COG1233	COG1233 Phytoene dehydrogenase and related
HALDL1_RS11290	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
HALDL1_RS11310	COG2155	Conserved Protein
HALDL1_RS11330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HALDL1_RS11340	COG0089	rRNA binding
HALDL1_RS11345	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HALDL1_RS11350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HALDL1_RS11360	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HALDL1_RS11365	COG0255	Belongs to the universal ribosomal protein uL29 family
HALDL1_RS11375	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HALDL1_RS11380	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HALDL1_RS11395	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HALDL1_RS11405	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HALDL1_RS11410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HALDL1_RS11415	COG0322	excinuclease ABC activity
HALDL1_RS11430	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HALDL1_RS11450	COG4191	Histidine kinase
HALDL1_RS11460	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HALDL1_RS11465	COG0531	amino acid
HALDL1_RS11490	COG0563	adenylate kinase activity
HALDL1_RS11500	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HALDL1_RS11505	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HALDL1_RS11515	COG0010	Belongs to the arginase family
HALDL1_RS11535	COG4251	negative regulation of phosphorylation
HALDL1_RS11550	COG1704	LemA family
HALDL1_RS11565	COG1278	Cold shock
HALDL1_RS11590	COG0129	dihydroxy-acid dehydratase activity
HALDL1_RS11670	COG0012	GTP binding
HALDL1_RS11675	COG1216	Glycosyl transferase, family 2
HALDL1_RS11715	COG0723	plastoquinol--plastocyanin reductase activity
HALDL1_RS11715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HALDL1_RS11730	COG3361	conserved protein (COG2071)
HALDL1_RS11740	COG1215	transferase activity, transferring glycosyl groups
HALDL1_RS11765	COG3634	alkyl hydroperoxide reductase activity
HALDL1_RS11795	COG0531	amino acid
HALDL1_RS11800	COG1253	flavin adenine dinucleotide binding
HALDL1_RS11840	COG0745	RESPONSE REGULATOR receiver
HALDL1_RS11850	COG1132	(ABC) transporter
HALDL1_RS11855	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HALDL1_RS11870	COG0436	Aminotransferase
HALDL1_RS11885	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HALDL1_RS11900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HALDL1_RS11910	COG2154	pterin-4-alpha-carbinolamine dehydratase
HALDL1_RS11915	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HALDL1_RS11920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HALDL1_RS11920	COG1648	precorrin-2 dehydrogenase activity
HALDL1_RS11935	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HALDL1_RS11940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HALDL1_RS11945	COG1836	PFAM Integral membrane protein DUF92
HALDL1_RS11950	COG0358	DNA primase activity
HALDL1_RS11970	COG3403	YqcI/YcgG family
HALDL1_RS11975	COG1335	isochorismatase
HALDL1_RS12000	COG0671	phosphoesterase, PA-phosphatase related
HALDL1_RS12015	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HALDL1_RS12020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HALDL1_RS12035	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HALDL1_RS12045	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HALDL1_RS12050	COG0066	3-isopropylmalate dehydratase activity
HALDL1_RS12055	COG0473	3-isopropylmalate dehydrogenase activity
HALDL1_RS12060	COG0083	homoserine kinase activity
HALDL1_RS12065	COG5002	protein histidine kinase activity
HALDL1_RS12080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HALDL1_RS12085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HALDL1_RS12105	COG0446	pyridine nucleotide-disulphide oxidoreductase
HALDL1_RS12130	COG1131	(ABC) transporter
HALDL1_RS12150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HALDL1_RS12155	COG0505	Belongs to the CarA family
HALDL1_RS12160	COG1522	sequence-specific DNA binding
HALDL1_RS12165	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HALDL1_RS12215	COG0519	Catalyzes the synthesis of GMP from XMP
HALDL1_RS12215	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HALDL1_RS12220	COG0504	CTP synthase activity
HALDL1_RS12245	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HALDL1_RS12260	COG4948	Mandelate Racemase Muconate Lactonizing
HALDL1_RS12290	COG0252	asparaginase activity
HALDL1_RS12325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HALDL1_RS12355	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HALDL1_RS12360	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HALDL1_RS12370	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HALDL1_RS12375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HALDL1_RS12380	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HALDL1_RS12410	COG1446	asparaginase
HALDL1_RS12415	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HALDL1_RS12425	COG0538	isocitrate dehydrogenase activity
HALDL1_RS12445	COG0022	dehydrogenase e1 component
HALDL1_RS12450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HALDL1_RS12485	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HALDL1_RS12510	COG0483	inositol monophosphate 1-phosphatase activity
HALDL1_RS12525	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HALDL1_RS12530	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HALDL1_RS12535	COG1469	GTP cyclohydrolase I activity
HALDL1_RS12580	COG1522	sequence-specific DNA binding
HALDL1_RS12585	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HALDL1_RS12615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HALDL1_RS12620	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HALDL1_RS12645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HALDL1_RS12660	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HALDL1_RS12665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HALDL1_RS12690	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HALDL1_RS12700	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HALDL1_RS12705	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HALDL1_RS12725	COG0047	phosphoribosylformylglycinamidine synthase activity
HALDL1_RS12735	COG0788	formyltetrahydrofolate deformylase activity
HALDL1_RS12745	COG3119	arylsulfatase activity
HALDL1_RS12755	COG0517	IMP dehydrogenase activity
HALDL1_RS12795	COG4251	negative regulation of phosphorylation
HALDL1_RS12805	COG1522	sequence-specific DNA binding
HALDL1_RS12830	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HALDL1_RS12880	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HALDL1_RS12905	COG0166	Belongs to the GPI family
HALDL1_RS12930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HALDL1_RS12945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HALDL1_RS12950	COG1164	Oligoendopeptidase f
HALDL1_RS12960	COG0101	tRNA pseudouridine synthase activity
HALDL1_RS12965	COG0124	histidyl-tRNA synthetase
HALDL1_RS12995	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HALDL1_RS13010	COG0314	molybdopterin synthase activity
HALDL1_RS13015	COG0528	UMP kinase activity
HALDL1_RS13045	COG0667	Aldo Keto reductase
HALDL1_RS13085	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HALDL1_RS13105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HALDL1_RS13120	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HALDL1_RS13130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HALDL1_RS13155	COG0539	negative regulation of cytoplasmic translation
HALDL1_RS13180	COG0464	growth
HALDL1_RS13190	COG0183	Belongs to the thiolase family
HALDL1_RS13210	COG4251	negative regulation of phosphorylation
HALDL1_RS13225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HALDL1_RS13235	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HALDL1_RS13240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HALDL1_RS13275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HALDL1_RS13290	COG1573	uracil-dna glycosylase
HALDL1_RS13295	COG3639	organic phosphonate transmembrane transporter activity
HALDL1_RS13300	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HALDL1_RS13310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HALDL1_RS13330	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
HALDL1_RS13335	COG1295	ribonuclease BN
HALDL1_RS13340	COG0671	phosphoesterase, PA-phosphatase related
HALDL1_RS13350	COG1522	sequence-specific DNA binding
HALDL1_RS13355	COG2204	response regulator
HALDL1_RS13360	COG0459	protein refolding
HALDL1_RS13380	COG0251	oxidation-reduction process
HALDL1_RS13385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HALDL1_RS13400	COG0798	PFAM Bile acid sodium symporter
HALDL1_RS13405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HALDL1_RS13425	COG0372	Belongs to the citrate synthase family
HALDL1_RS13450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HALDL1_RS13490	COG2252	PERMEase
HALDL1_RS13500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HALDL1_RS13530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HALDL1_RS13535	COG1757	Na H antiporter
HALDL1_RS13560	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HALDL1_RS13570	COG0731	radical SAM domain protein
HALDL1_RS13580	COG1028	Short-chain dehydrogenase reductase Sdr
HALDL1_RS13610	COG0018	arginyl-trna synthetase
HALDL1_RS13635	COG1012	belongs to the aldehyde dehydrogenase family
HALDL1_RS13665	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HALDL1_RS13690	COG1269	ATP hydrolysis coupled proton transport
HALDL1_RS13735	COG0142	geranyltranstransferase activity
HALDL1_RS13815	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HALDL1_RS13840	COG0596	Alpha beta hydrolase
HALDL1_RS13855	COG3971	2-oxopent-4-enoate hydratase activity
HALDL1_RS13860	COG2368	4-hydroxyphenylacetate
HALDL1_RS13865	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HALDL1_RS13870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HALDL1_RS13880	COG0559	Belongs to the binding-protein-dependent transport system permease family
HALDL1_RS13895	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HALDL1_RS13895	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HALDL1_RS13900	COG1414	Transcriptional regulator
HALDL1_RS13925	COG3246	L-lysine catabolic process to acetate
HALDL1_RS13955	COG0745	RESPONSE REGULATOR receiver
HALDL1_RS13965	COG0471	metal ion transport
HALDL1_RS14030	COG1192	Involved in chromosome partitioning
HALDL1_RS14050	COG2205	protein histidine kinase activity
HALDL1_RS14055	COG0537	adenosine 5'-monophosphoramidase activity
HALDL1_RS14075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HALDL1_RS14110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HALDL1_RS14120	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HALDL1_RS14145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HALDL1_RS14160	COG0131	Imidazoleglycerol-phosphate dehydratase
HALDL1_RS14180	COG1739	Uncharacterized protein family UPF0029
HALDL1_RS14185	COG0823	Involved in the tonB-independent uptake of proteins
HALDL1_RS14185	COG1506	peptidase
HALDL1_RS14185	COG4946	Tricorn protease homolog
HALDL1_RS14195	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HALDL1_RS14210	COG1253	flavin adenine dinucleotide binding
HALDL1_RS14225	COG0009	L-threonylcarbamoyladenylate synthase
HALDL1_RS14250	COG0247	lactate metabolic process
HALDL1_RS14250	COG2181	nitrate reductase activity
HALDL1_RS14275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HALDL1_RS14285	COG0113	porphobilinogen synthase activity
HALDL1_RS14305	COG0004	ammonium transporteR
HALDL1_RS14310	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HALDL1_RS14320	COG0181	hydroxymethylbilane synthase activity
HALDL1_RS14325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HALDL1_RS14325	COG1648	precorrin-2 dehydrogenase activity
HALDL1_RS14350	COG1733	regulation of RNA biosynthetic process
HALDL1_RS14385	COG4251	negative regulation of phosphorylation
HALDL1_RS14390	COG0784	Response regulator, receiver
HALDL1_RS14405	COG4166	transmembrane transport
HALDL1_RS14410	COG4174	ABC transporter (Permease)
HALDL1_RS14415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALDL1_RS14420	COG0444	Belongs to the ABC transporter superfamily
HALDL1_RS14425	COG4608	Belongs to the ABC transporter superfamily
HALDL1_RS14440	COG0517	IMP dehydrogenase activity
HALDL1_RS14440	COG0516	GMP reductase activity
HALDL1_RS14455	COG0556	nucleotide-excision repair
HALDL1_RS14460	COG0589	response to stress
HALDL1_RS14470	COG0039	L-malate dehydrogenase activity
HALDL1_RS14475	COG0251	oxidation-reduction process
HALDL1_RS14555	COG4974	Belongs to the 'phage' integrase family
HALDL1_RS14595	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HALDL1_RS14640	COG2267	carboxylic ester hydrolase activity
HALDL1_RS14650	COG0527	aspartate kinase activity
HALDL1_RS14695	COG0322	excinuclease ABC activity
HALDL1_RS14715	COG1131	(ABC) transporter
HALDL1_RS14720	COG0556	nucleotide-excision repair
HALDL1_RS14735	COG2897	thiosulfate sulfurtransferase activity
HALDL1_RS14740	COG2897	thiosulfate sulfurtransferase activity
HALDL1_RS14755	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HALDL1_RS14760	COG3842	ATPase activity
HALDL1_RS14770	COG2226	methyltransferase
HALDL1_RS14790	COG0534	Mate efflux family protein
HALDL1_RS14805	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HALDL1_RS14870	COG1518	maintenance of DNA repeat elements
HALDL1_RS14875	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HALDL1_RS14890	COG1192	Involved in chromosome partitioning
HALDL1_RS14935	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HALDL1_RS14940	COG0602	queuosine metabolic process
HALDL1_RS14950	COG2217	Heavy metal translocating P-type atpase
HALDL1_RS14960	COG2217	Heavy metal translocating P-type atpase
HALDL1_RS14970	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HALDL1_RS15000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HALDL1_RS15000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HALDL1_RS15005	COG2132	Multicopper oxidase
HALDL1_RS15025	COG3794	PFAM blue (type 1) copper domain protein
HALDL1_RS15035	COG1192	Involved in chromosome partitioning
HALDL1_RS15085	COG0701	Predicted permease
HALDL1_RS15210	COG3385	transposase activity
HALDL1_RS15405	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HALDL1_RS15525	COG2124	cytochrome p450
HALDL1_RS15540	COG1570	exodeoxyribonuclease VII activity
HALDL1_RS15660	COG3385	transposase activity
HALDL1_RS15675	COG1192	Involved in chromosome partitioning
HALDL1_RS16040	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HALDL1_RS16055	COG2217	Heavy metal translocating P-type atpase
HALDL1_RS16085	COG1605	Chorismate mutase
HALDL1_RS16085	COG0077	Prephenate dehydratase
HALDL1_RS16115	COG0420	3'-5' exonuclease activity
HALDL1_RS16240	COG1403	HNH endonuclease
HALDL1_RS16260	COG4249	Peptidase C14 caspase catalytic subunit p20
HALDL1_RS16390	COG0402	S-adenosylhomocysteine deaminase activity
HALDL1_RS16395	COG4251	negative regulation of phosphorylation