locus-tag	class	description
JT689_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JT689_RS00125	COG2894	cell division
JT689_RS00210	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
JT689_RS00215	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
JT689_RS00220	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
JT689_RS00280	COG0864	Transcriptional regulator
JT689_RS00300	COG0071	Belongs to the small heat shock protein (HSP20) family
JT689_RS00360	COG0569	domain protein
JT689_RS00365	COG0531	amino acid
JT689_RS00480	COG0095	Lipoate-protein ligase
JT689_RS00485	COG0402	S-adenosylhomocysteine deaminase activity
JT689_RS00495	COG0733	neurotransmitter:sodium symporter activity
JT689_RS00500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JT689_RS00505	COG1121	(ABC) transporter
JT689_RS00520	COG1297	OPT oligopeptide transporter protein
JT689_RS00560	COG0395	ABC-type sugar transport system, permease component
JT689_RS00565	COG3842	ATPase activity
JT689_RS00570	COG0697	spore germination
JT689_RS00575	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
JT689_RS00580	COG2267	carboxylic ester hydrolase activity
JT689_RS00615	COG1785	Belongs to the alkaline phosphatase family
JT689_RS00620	COG1253	flavin adenine dinucleotide binding
JT689_RS00625	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JT689_RS00630	COG0602	queuosine metabolic process
JT689_RS00640	COG1301	dicarboxylic acid transport
JT689_RS00645	COG0540	Belongs to the ATCase OTCase family
JT689_RS00650	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
JT689_RS00655	COG0018	arginyl-trna synthetase
JT689_RS00660	COG1757	Na H antiporter
JT689_RS00665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JT689_RS00680	COG1414	Transcriptional regulator
JT689_RS00790	COG1131	(ABC) transporter
JT689_RS00820	COG0471	metal ion transport
JT689_RS00830	COG1131	(ABC) transporter
JT689_RS00845	COG3842	ATPase activity
JT689_RS00855	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
JT689_RS00890	COG1111	helicase
JT689_RS00890	COG1205	dead DEAH box helicase
JT689_RS00920	COG0569	domain protein
JT689_RS00925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JT689_RS00935	COG0419	ATPase involved in DNA repair
JT689_RS00940	COG0420	3'-5' exonuclease activity
JT689_RS00990	COG1271	oxidase subunit
JT689_RS01115	COG2226	methyltransferase
JT689_RS01140	COG2210	Belongs to the sulfur carrier protein TusA family
JT689_RS01145	COG0425	Belongs to the sulfur carrier protein TusA family
JT689_RS01150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JT689_RS01150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JT689_RS01165	COG0306	phosphate transporter
JT689_RS01200	COG0864	Transcriptional regulator
JT689_RS01330	COG0640	Transcriptional regulator
JT689_RS01360	COG2226	methyltransferase
JT689_RS01560	COG0470	DNA polymerase III
JT689_RS01560	COG1067	ATP-dependent peptidase activity
JT689_RS01615	COG1192	Involved in chromosome partitioning
JT689_RS01675	COG1136	(ABC) transporter
JT689_RS01675	COG0577	efflux transmembrane transporter activity
JT689_RS01680	COG0577	efflux transmembrane transporter activity
JT689_RS01680	COG1136	(ABC) transporter
JT689_RS01690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JT689_RS01695	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JT689_RS01700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JT689_RS01705	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JT689_RS01760	COG1216	Glycosyl transferase, family 2
JT689_RS01790	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JT689_RS01795	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JT689_RS01805	COG0303	'Molybdopterin
JT689_RS01810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JT689_RS01850	COG1278	Cold shock
JT689_RS01855	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
JT689_RS01860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JT689_RS01900	COG4221	oxidoreductase activity
JT689_RS01915	COG1132	(ABC) transporter
JT689_RS01935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JT689_RS02035	COG0864	Transcriptional regulator
JT689_RS02070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JT689_RS02090	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JT689_RS02105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JT689_RS02110	COG0318	PFAM AMP-dependent synthetase and ligase
JT689_RS02115	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JT689_RS02140	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JT689_RS02150	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JT689_RS02155	COG0531	amino acid
JT689_RS02195	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JT689_RS02200	COG2226	methyltransferase
JT689_RS02200	COG1073	alpha beta
JT689_RS02220	COG1078	dGTPase activity
JT689_RS02225	COG0590	tRNA wobble adenosine to inosine editing
JT689_RS02225	COG0037	tRNA processing
JT689_RS02230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JT689_RS02315	COG0714	Associated with various cellular activities
JT689_RS02325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JT689_RS02400	COG0717	Belongs to the dCTP deaminase family
JT689_RS02430	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
JT689_RS02440	COG0328	RNA-DNA hybrid ribonuclease activity
JT689_RS02455	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JT689_RS02470	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JT689_RS02485	COG0656	L-ascorbic acid biosynthetic process
JT689_RS02495	COG1215	transferase activity, transferring glycosyl groups
JT689_RS02510	COG1233	COG1233 Phytoene dehydrogenase and related
JT689_RS02570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JT689_RS02580	COG2226	methyltransferase
JT689_RS02595	COG2860	membrane
JT689_RS02620	COG0134	indole-3-glycerol-phosphate synthase activity
JT689_RS02625	COG0133	tryptophan synthase activity
JT689_RS02630	COG0159	tryptophan synthase activity
JT689_RS02635	COG1830	Aldolase
JT689_RS02645	COG1465	3-dehydroquinate synthase
JT689_RS02665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JT689_RS02670	COG1215	transferase activity, transferring glycosyl groups
JT689_RS02705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JT689_RS02705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JT689_RS02710	COG0076	glutamate decarboxylase activity
JT689_RS02715	COG0501	Belongs to the peptidase M48B family
JT689_RS02720	COG0574	Belongs to the PEP-utilizing enzyme family
JT689_RS02720	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JT689_RS02730	COG0384	phenazine biosynthesis protein PhzF
JT689_RS02745	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
JT689_RS02760	COG1196	nuclear chromosome segregation
JT689_RS02770	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JT689_RS02805	COG0840	transmembrane signaling receptor activity
JT689_RS02830	COG1515	deoxyribonuclease V activity
JT689_RS02835	COG1028	Short-chain dehydrogenase reductase Sdr
JT689_RS02840	COG0003	Pfam Anion-transporting ATPase
JT689_RS02850	COG1058	Belongs to the CinA family
JT689_RS02850	COG1546	Belongs to the CinA family
JT689_RS02865	COG1960	acyl-CoA dehydrogenase activity
JT689_RS02890	COG1234	tRNA 3'-trailer cleavage
JT689_RS02900	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JT689_RS02910	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JT689_RS02915	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JT689_RS02915	COG0512	Glutamine amidotransferase of anthranilate synthase
JT689_RS02935	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JT689_RS02960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JT689_RS02970	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
JT689_RS02980	COG0442	prolyl-tRNA aminoacylation
JT689_RS02995	COG0371	Dehydrogenase
JT689_RS03010	COG1505	serine-type exopeptidase activity
JT689_RS03020	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JT689_RS03025	COG0138	bifunctional purine biosynthesis protein purh
JT689_RS03050	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JT689_RS03055	COG2124	cytochrome p450
JT689_RS03075	COG0477	Major facilitator Superfamily
JT689_RS03080	COG1024	Enoyl-CoA hydratase
JT689_RS03115	COG1473	amidohydrolase
JT689_RS03120	COG0445	tRNA wobble uridine modification
JT689_RS03130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JT689_RS03130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JT689_RS03140	COG4948	Mandelate Racemase Muconate Lactonizing
JT689_RS03145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JT689_RS03160	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JT689_RS03165	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JT689_RS03170	COG0704	Plays a role in the regulation of phosphate uptake
JT689_RS03175	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JT689_RS03180	COG0573	inorganic phosphate transmembrane transporter activity
JT689_RS03185	COG0573	inorganic phosphate transmembrane transporter activity
JT689_RS03205	COG0017	Asparaginyl-tRNA synthetase
JT689_RS03220	COG1131	(ABC) transporter
JT689_RS03230	COG0656	L-ascorbic acid biosynthetic process
JT689_RS03250	COG1476	TRANSCRIPTIONal
JT689_RS03260	COG1013	pyruvate-flavodoxin oxidoreductase activity
JT689_RS03265	COG0674	pyruvate-flavodoxin oxidoreductase activity
JT689_RS03265	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JT689_RS03280	COG0346	lactoylglutathione lyase activity
JT689_RS03285	COG1028	Short-chain dehydrogenase reductase Sdr
JT689_RS03290	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JT689_RS03290	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JT689_RS03305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JT689_RS03330	COG0484	heat shock protein binding
JT689_RS03335	COG0443	Heat shock 70 kDa protein
JT689_RS03370	COG2814	Major facilitator Superfamily
JT689_RS03375	COG0436	Aminotransferase
JT689_RS03390	COG1253	flavin adenine dinucleotide binding
JT689_RS03415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JT689_RS03430	COG0419	ATPase involved in DNA repair
JT689_RS03460	COG4221	oxidoreductase activity
JT689_RS03465	COG0396	ATPase activity
JT689_RS03470	COG0719	Fe-S assembly protein
JT689_RS03475	COG0719	Fe-S assembly protein
JT689_RS03515	COG1321	iron dependent repressor
JT689_RS03530	COG2358	TRAP transporter, solute receptor (TAXI family
JT689_RS03540	COG1233	COG1233 Phytoene dehydrogenase and related
JT689_RS03550	COG0484	heat shock protein binding
JT689_RS03565	COG1098	S1 RNA binding domain
JT689_RS03610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JT689_RS03615	COG0651	ATP synthesis coupled electron transport
JT689_RS03620	COG0651	ATP synthesis coupled electron transport
JT689_RS03625	COG0651	ATP synthesis coupled electron transport
JT689_RS03630	COG1006	Multisubunit Na H antiporter MnhC subunit
JT689_RS03645	COG1320	monovalent cation:proton antiporter activity
JT689_RS03650	COG2212	antiporter activity
JT689_RS03655	COG1863	multisubunit Na H antiporter MnhE subunit
JT689_RS03660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JT689_RS03680	COG2234	aminopeptidase activity
JT689_RS03705	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JT689_RS03710	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JT689_RS03745	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JT689_RS03765	COG0346	lactoylglutathione lyase activity
JT689_RS03780	COG0438	transferase activity, transferring glycosyl groups
JT689_RS03785	COG0438	transferase activity, transferring glycosyl groups
JT689_RS03820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JT689_RS03825	COG1832	CoA-binding protein
JT689_RS03865	COG0616	signal peptide processing
JT689_RS03875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JT689_RS03885	COG2030	dehydratase
JT689_RS03890	COG2301	Belongs to the HpcH HpaI aldolase family
JT689_RS03895	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JT689_RS03905	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JT689_RS03915	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JT689_RS03925	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JT689_RS03930	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JT689_RS03935	COG0649	NAD binding
JT689_RS03935	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JT689_RS03940	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JT689_RS03945	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JT689_RS03970	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JT689_RS03975	COG1007	ATP synthesis coupled electron transport
JT689_RS03980	COG1227	inorganic diphosphatase activity
JT689_RS03985	COG2239	Acts as a magnesium transporter
JT689_RS03995	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JT689_RS03995	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JT689_RS04035	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JT689_RS04040	COG0109	protoheme IX farnesyltransferase activity
JT689_RS04050	COG1131	(ABC) transporter
JT689_RS04070	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JT689_RS04070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JT689_RS04080	COG2267	carboxylic ester hydrolase activity
JT689_RS04100	COG1960	acyl-CoA dehydrogenase activity
JT689_RS04110	COG1250	3-hydroxyacyl-CoA dehydrogenase
JT689_RS04120	COG1830	Aldolase
JT689_RS04125	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
JT689_RS04140	COG4555	ABC transporter
JT689_RS04180	COG2217	Heavy metal translocating P-type atpase
JT689_RS04200	COG3046	protein related to deoxyribodipyrimidine photolyase
JT689_RS04215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JT689_RS04230	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JT689_RS04245	COG0561	phosphatase activity
JT689_RS04255	COG0534	Mate efflux family protein
JT689_RS04280	COG0534	Mate efflux family protein
JT689_RS04300	COG0430	RNA-3'-phosphate cyclase activity
JT689_RS04315	COG0745	RESPONSE REGULATOR receiver
JT689_RS04320	COG0642	Histidine kinase
JT689_RS04360	COG2718	Belongs to the UPF0229 family
JT689_RS04370	COG2766	serine protein kinase
JT689_RS04420	COG1546	Belongs to the CinA family
JT689_RS04420	COG1058	Belongs to the CinA family
JT689_RS04425	COG0671	phosphoesterase, PA-phosphatase related
JT689_RS04470	COG1960	acyl-CoA dehydrogenase activity
JT689_RS04475	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
JT689_RS04475	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JT689_RS04505	COG3794	PFAM blue (type 1) copper domain protein
JT689_RS04535	COG0840	transmembrane signaling receptor activity
JT689_RS04550	COG0626	cystathionine gamma-synthase activity
JT689_RS04560	COG1136	(ABC) transporter
JT689_RS04575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JT689_RS04585	COG0840	transmembrane signaling receptor activity
JT689_RS04585	COG3290	protein histidine kinase activity
JT689_RS04605	COG0840	transmembrane signaling receptor activity
JT689_RS04615	COG0702	epimerase
JT689_RS04620	COG2130	NADP-dependent
JT689_RS04635	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
JT689_RS04660	COG0746	molybdenum cofactor guanylyltransferase activity
JT689_RS04680	COG0243	molybdopterin cofactor binding
JT689_RS04775	COG3679	Belongs to the UPF0342 family
JT689_RS04785	COG2890	protein-(glutamine-N5) methyltransferase activity
JT689_RS04800	COG0107	imidazoleglycerol-phosphate synthase activity
JT689_RS04815	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JT689_RS04820	COG0587	DNA-directed DNA polymerase activity
JT689_RS04840	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JT689_RS04845	COG0154	amidase activity
JT689_RS04850	COG1607	acyl-coa hydrolase
JT689_RS04865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JT689_RS04885	COG1793	dna ligase
JT689_RS04890	COG0647	UMP catabolic process
JT689_RS04910	COG0187	DNA topoisomerase II activity
JT689_RS04915	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JT689_RS04925	COG1252	NADH dehydrogenase
JT689_RS04935	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
JT689_RS04940	COG0813	purine-nucleoside phosphorylase activity
JT689_RS04950	COG1079	Belongs to the binding-protein-dependent transport system permease family
JT689_RS04955	COG4603	Belongs to the binding-protein-dependent transport system permease family
JT689_RS04960	COG3845	ABC transporter
JT689_RS04965	COG1744	ABC transporter substrate-binding protein PnrA-like
JT689_RS04970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JT689_RS04985	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JT689_RS05010	COG3844	kynureninase activity
JT689_RS05015	COG4191	Histidine kinase
JT689_RS05020	COG0745	RESPONSE REGULATOR receiver
JT689_RS05035	COG3842	ATPase activity
JT689_RS05065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JT689_RS05080	COG1902	pentaerythritol trinitrate reductase activity
JT689_RS05100	COG1012	belongs to the aldehyde dehydrogenase family
JT689_RS05115	COG0857	belongs to the CobB CobQ family
JT689_RS05135	COG2894	cell division
JT689_RS05150	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JT689_RS05220	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
JT689_RS05235	COG2198	Histidine kinase
JT689_RS05235	COG0643	Histidine kinase
JT689_RS05240	COG2201	protein-glutamate methylesterase activity
JT689_RS05245	COG2201	protein-glutamate methylesterase activity
JT689_RS05320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JT689_RS05325	COG0667	Aldo Keto reductase
JT689_RS05345	COG0517	IMP dehydrogenase activity
JT689_RS05345	COG0516	GMP reductase activity
JT689_RS05405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JT689_RS05420	COG0656	L-ascorbic acid biosynthetic process
JT689_RS05440	COG0720	synthase
JT689_RS05475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JT689_RS05495	COG0179	Fumarylacetoacetate (FAA) hydrolase
JT689_RS05500	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JT689_RS05530	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
JT689_RS05560	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
JT689_RS05565	COG1086	Polysaccharide biosynthesis protein
JT689_RS05575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JT689_RS05580	COG2089	acid synthase
JT689_RS05595	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
JT689_RS05605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JT689_RS05610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JT689_RS05630	COG1215	transferase activity, transferring glycosyl groups
JT689_RS05645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JT689_RS05655	COG0318	PFAM AMP-dependent synthetase and ligase
JT689_RS05660	COG1441	menaquinone biosynthetic process
JT689_RS05665	COG1575	Belongs to the MenA family. Type 1 subfamily
JT689_RS05675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JT689_RS05680	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JT689_RS05715	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JT689_RS05755	COG0215	cysteine-tRNA ligase activity
JT689_RS05765	COG1335	isochorismatase
JT689_RS05785	COG0081	regulation of translation
JT689_RS05790	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JT689_RS05800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JT689_RS05810	COG0346	lactoylglutathione lyase activity
JT689_RS05825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JT689_RS05895	COG0436	Aminotransferase
JT689_RS05905	COG1013	pyruvate-flavodoxin oxidoreductase activity
JT689_RS05910	COG0674	pyruvate-flavodoxin oxidoreductase activity
JT689_RS05910	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JT689_RS05920	COG0489	protein tyrosine kinase activity
JT689_RS05930	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JT689_RS05940	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JT689_RS05965	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JT689_RS05980	COG0148	phosphopyruvate hydratase activity
JT689_RS05985	COG0052	Belongs to the universal ribosomal protein uS2 family
JT689_RS05995	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JT689_RS06005	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JT689_RS06020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JT689_RS06030	COG1444	tRNA N-acetyltransferase activity
JT689_RS06050	COG0105	UTP biosynthetic process
JT689_RS06060	COG2890	protein-(glutamine-N5) methyltransferase activity
JT689_RS06070	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JT689_RS06095	COG0626	cystathionine gamma-synthase activity
JT689_RS06110	COG2205	protein histidine kinase activity
JT689_RS06135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JT689_RS06150	COG0535	radical SAM domain protein
JT689_RS06160	COG0535	radical SAM domain protein
JT689_RS06185	COG1960	acyl-CoA dehydrogenase activity
JT689_RS06210	COG0644	oxidoreductase
JT689_RS06230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JT689_RS06235	COG0402	S-adenosylhomocysteine deaminase activity
JT689_RS06255	COG0010	Belongs to the arginase family
JT689_RS06260	COG1228	amidohydrolase
JT689_RS06265	COG2986	histidine ammonia-lyase
JT689_RS06285	COG0126	phosphoglycerate kinase activity
JT689_RS06295	COG0572	uridine kinase
JT689_RS06335	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JT689_RS06345	COG4191	Histidine kinase
JT689_RS06355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JT689_RS06380	COG1522	sequence-specific DNA binding
JT689_RS06390	COG0531	amino acid
JT689_RS06395	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
JT689_RS06405	COG0287	Prephenate dehydrogenase
JT689_RS06405	COG1605	Chorismate mutase
JT689_RS06420	COG1131	(ABC) transporter
JT689_RS06435	COG1201	RNA secondary structure unwinding
JT689_RS06465	COG0492	ferredoxin-NADP+ reductase activity
JT689_RS06525	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JT689_RS06525	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JT689_RS06530	COG0315	cyclic pyranopterin monophosphate synthase activity
JT689_RS06540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JT689_RS06555	COG2890	protein-(glutamine-N5) methyltransferase activity
JT689_RS06575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JT689_RS06600	COG1047	Peptidyl-prolyl cis-trans
JT689_RS06615	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
JT689_RS06620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JT689_RS06620	COG0301	tRNA thio-modification
JT689_RS06630	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JT689_RS06640	COG1331	Highly conserved protein containing a thioredoxin domain
JT689_RS06645	COG0151	Belongs to the GarS family
JT689_RS06650	COG1053	succinate dehydrogenase
JT689_RS06655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JT689_RS06675	COG1250	3-hydroxyacyl-CoA dehydrogenase
JT689_RS06740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JT689_RS06755	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JT689_RS06760	COG0415	Belongs to the DNA photolyase family
JT689_RS06775	COG0318	PFAM AMP-dependent synthetase and ligase
JT689_RS06790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JT689_RS06800	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JT689_RS06810	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
JT689_RS06820	COG0697	spore germination
JT689_RS06825	COG1522	sequence-specific DNA binding
JT689_RS06830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JT689_RS06845	COG0114	fumarate hydratase activity
JT689_RS06850	COG0271	Belongs to the BolA IbaG family
JT689_RS06890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JT689_RS06895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JT689_RS06900	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
JT689_RS06910	COG4191	Histidine kinase
JT689_RS06915	COG2205	protein histidine kinase activity
JT689_RS06925	COG1522	sequence-specific DNA binding
JT689_RS06930	COG0483	inositol monophosphate 1-phosphatase activity
JT689_RS06965	COG0110	maltose O-acetyltransferase activity
JT689_RS07015	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
JT689_RS07045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JT689_RS07060	COG0737	Belongs to the 5'-nucleotidase family
JT689_RS07085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JT689_RS07090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JT689_RS07140	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JT689_RS07145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JT689_RS07190	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JT689_RS07210	COG0737	Belongs to the 5'-nucleotidase family
JT689_RS07245	COG0456	acetyltransferase
JT689_RS07265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JT689_RS07275	COG3920	Histidine kinase
JT689_RS07275	COG2202	Pas domain
JT689_RS07300	COG0632	four-way junction helicase activity
JT689_RS07310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JT689_RS07335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JT689_RS07350	COG1045	serine acetyltransferase
JT689_RS07355	COG1960	acyl-CoA dehydrogenase activity
JT689_RS07400	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JT689_RS07415	COG1363	Peptidase, m42
JT689_RS07435	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JT689_RS07440	COG1234	tRNA 3'-trailer cleavage
JT689_RS07480	COG1435	thymidine kinase activity
JT689_RS07500	COG4249	Peptidase C14 caspase catalytic subunit p20
JT689_RS07505	COG1194	a g-specific adenine glycosylase
JT689_RS07520	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JT689_RS07525	COG1285	pathogenesis
JT689_RS07530	COG0733	neurotransmitter:sodium symporter activity
JT689_RS07535	COG0733	neurotransmitter:sodium symporter activity
JT689_RS07540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JT689_RS07550	COG4770	biotin carboxylase activity
JT689_RS07565	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
JT689_RS07565	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
JT689_RS07570	COG0589	response to stress
JT689_RS07575	COG1078	dGTPase activity
JT689_RS07585	COG1028	Short-chain dehydrogenase reductase Sdr
JT689_RS07595	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JT689_RS07605	COG0038	chloride channel
JT689_RS07625	COG2096	Adenosyltransferase
JT689_RS07665	COG1648	precorrin-2 dehydrogenase activity
JT689_RS07665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JT689_RS07685	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
JT689_RS07700	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
JT689_RS07725	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JT689_RS07740	COG1492	cobalamin metabolic process
JT689_RS07755	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
JT689_RS07765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JT689_RS07800	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JT689_RS07805	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JT689_RS07810	COG0509	glycine decarboxylation via glycine cleavage system
JT689_RS07815	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JT689_RS07865	COG0655	NAD(P)H dehydrogenase (quinone) activity
JT689_RS07890	COG2255	four-way junction helicase activity
JT689_RS07900	COG0281	malic enzyme
JT689_RS07900	COG0280	phosphate acetyltransferase
JT689_RS07915	COG0667	Aldo Keto reductase
JT689_RS07925	COG1122	ATPase activity
JT689_RS07935	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
JT689_RS07980	COG0512	Glutamine amidotransferase of anthranilate synthase
JT689_RS07985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JT689_RS07990	COG0135	phosphoribosylanthranilate isomerase activity
JT689_RS07995	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JT689_RS08025	COG0589	response to stress
JT689_RS08060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JT689_RS08080	COG0284	orotidine-5'-phosphate decarboxylase activity
JT689_RS08090	COG0484	heat shock protein binding
JT689_RS08100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JT689_RS08125	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JT689_RS08130	COG1233	COG1233 Phytoene dehydrogenase and related
JT689_RS08135	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
JT689_RS08155	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JT689_RS08160	COG0088	Forms part of the polypeptide exit tunnel
JT689_RS08170	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JT689_RS08175	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JT689_RS08185	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JT689_RS08190	COG0255	Belongs to the universal ribosomal protein uL29 family
JT689_RS08200	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JT689_RS08205	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JT689_RS08230	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JT689_RS08235	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JT689_RS08240	COG0322	excinuclease ABC activity
JT689_RS08255	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JT689_RS08280	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JT689_RS08295	COG0563	adenylate kinase activity
JT689_RS08305	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JT689_RS08310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JT689_RS08380	COG3361	conserved protein (COG2071)
JT689_RS08390	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JT689_RS08405	COG0415	Belongs to the DNA photolyase family
JT689_RS08455	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JT689_RS08460	COG0010	Belongs to the arginase family
JT689_RS08475	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JT689_RS08490	COG2154	pterin-4-alpha-carbinolamine dehydratase
JT689_RS08495	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JT689_RS08500	COG1648	precorrin-2 dehydrogenase activity
JT689_RS08500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JT689_RS08505	COG1522	sequence-specific DNA binding
JT689_RS08515	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JT689_RS08520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JT689_RS08525	COG1836	PFAM Integral membrane protein DUF92
JT689_RS08530	COG0358	DNA primase activity
JT689_RS08565	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
JT689_RS08575	COG0083	homoserine kinase activity
JT689_RS08660	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
JT689_RS08675	COG0604	alcohol dehydrogenase
JT689_RS08680	COG0521	Mo-molybdopterin cofactor biosynthetic process
JT689_RS08700	COG0519	Catalyzes the synthesis of GMP from XMP
JT689_RS08700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JT689_RS08705	COG0504	CTP synthase activity
JT689_RS08725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JT689_RS08765	COG0252	asparaginase activity
JT689_RS08780	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
JT689_RS08785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JT689_RS08810	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
JT689_RS08825	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JT689_RS08830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JT689_RS08860	COG1176	ABC-type spermidine putrescine transport system, permease component I
JT689_RS08870	COG3842	ATPase activity
JT689_RS08910	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JT689_RS08915	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JT689_RS08935	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JT689_RS08980	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JT689_RS09025	COG1522	sequence-specific DNA binding
JT689_RS09030	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JT689_RS09035	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JT689_RS09055	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
JT689_RS09065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JT689_RS09100	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JT689_RS09125	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
JT689_RS09130	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
JT689_RS09135	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JT689_RS09165	COG0047	phosphoribosylformylglycinamidine synthase activity
JT689_RS09175	COG0788	formyltetrahydrofolate deformylase activity
JT689_RS09190	COG1404	Belongs to the peptidase S8 family
JT689_RS09250	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JT689_RS09255	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JT689_RS09260	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
JT689_RS09265	COG0247	lactate metabolic process
JT689_RS09320	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JT689_RS09325	COG1757	Na H antiporter
JT689_RS09340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JT689_RS09355	COG0166	Belongs to the GPI family
JT689_RS09375	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JT689_RS09400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JT689_RS09405	COG1164	Oligoendopeptidase f
JT689_RS09415	COG0101	tRNA pseudouridine synthase activity
JT689_RS09420	COG0124	histidyl-tRNA synthetase
JT689_RS09440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JT689_RS09455	COG0528	UMP kinase activity
JT689_RS09470	COG1695	Transcriptional regulator
JT689_RS09475	COG3253	May function as heme-dependent peroxidase
JT689_RS09485	COG0667	Aldo Keto reductase
JT689_RS09520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JT689_RS09525	COG1024	Enoyl-CoA hydratase
JT689_RS09545	COG0745	RESPONSE REGULATOR receiver
JT689_RS09550	COG2205	protein histidine kinase activity
JT689_RS09565	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JT689_RS09575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JT689_RS09600	COG1185	polyribonucleotide nucleotidyltransferase activity
JT689_RS09625	COG0464	growth
JT689_RS09635	COG0183	Belongs to the thiolase family
JT689_RS09655	COG1022	Amp-dependent synthetase and ligase
JT689_RS09665	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JT689_RS09695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JT689_RS09710	COG1573	uracil-dna glycosylase
JT689_RS09720	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
JT689_RS09730	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JT689_RS09740	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
JT689_RS09765	COG0459	protein refolding
JT689_RS09770	COG2311	Membrane
JT689_RS09785	COG0251	oxidation-reduction process
JT689_RS09790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JT689_RS09800	COG0372	Belongs to the citrate synthase family
JT689_RS09820	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JT689_RS09850	COG2252	PERMEase
JT689_RS09855	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JT689_RS09860	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JT689_RS09880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JT689_RS09885	COG1757	Na H antiporter
JT689_RS09890	COG1757	Na H antiporter
JT689_RS09895	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JT689_RS09905	COG0731	radical SAM domain protein
JT689_RS09920	COG0484	heat shock protein binding
JT689_RS09980	COG1269	ATP hydrolysis coupled proton transport
JT689_RS10015	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
JT689_RS10025	COG0142	geranyltranstransferase activity
JT689_RS10055	COG0662	Cupin 2, conserved barrel domain protein
JT689_RS10055	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
JT689_RS10180	COG0537	adenosine 5'-monophosphoramidase activity
JT689_RS10195	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JT689_RS10205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JT689_RS10255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JT689_RS10285	COG0534	Mate efflux family protein
JT689_RS10290	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JT689_RS10320	COG0495	leucyl-tRNA aminoacylation
JT689_RS10330	COG0459	protein refolding
JT689_RS10335	COG1185	polyribonucleotide nucleotidyltransferase activity
JT689_RS10370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JT689_RS10380	COG1234	tRNA 3'-trailer cleavage
JT689_RS10395	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JT689_RS10395	COG0116	Belongs to the methyltransferase superfamily
JT689_RS10415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JT689_RS10425	COG0402	S-adenosylhomocysteine deaminase activity
JT689_RS10430	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
JT689_RS10450	COG0688	phosphatidylethanolamine metabolic process
JT689_RS10465	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
JT689_RS10485	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
JT689_RS10500	COG0805	protein transport
JT689_RS10505	COG0805	protein transport
JT689_RS10520	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JT689_RS10530	COG2827	Endonuclease containing a URI domain
JT689_RS10535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JT689_RS10555	COG0435	Glutathione S-transferase
JT689_RS10565	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JT689_RS10570	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JT689_RS10580	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JT689_RS10585	COG4865	methylaspartate mutase activity
JT689_RS10590	COG3799	methylaspartate ammonia-lyase activity
JT689_RS10600	COG0427	acetyl-CoA hydrolase
JT689_RS10610	COG0633	Ferredoxin
JT689_RS10615	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JT689_RS10620	COG0131	Imidazoleglycerol-phosphate dehydratase
JT689_RS10640	COG1739	Uncharacterized protein family UPF0029
JT689_RS10650	COG0492	ferredoxin-NADP+ reductase activity
JT689_RS10655	COG0823	Involved in the tonB-independent uptake of proteins
JT689_RS10655	COG1506	peptidase
JT689_RS10655	COG4946	Tricorn protease homolog
JT689_RS10665	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JT689_RS10680	COG1253	flavin adenine dinucleotide binding
JT689_RS10695	COG0009	L-threonylcarbamoyladenylate synthase
JT689_RS10720	COG1268	BioY protein
JT689_RS10725	COG1122	ATPase activity
JT689_RS10735	COG0247	lactate metabolic process
JT689_RS10735	COG2181	nitrate reductase activity
JT689_RS10750	COG0113	porphobilinogen synthase activity
JT689_RS10760	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JT689_RS10775	COG0181	hydroxymethylbilane synthase activity
JT689_RS10780	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JT689_RS10795	COG3852	Histidine kinase
JT689_RS10845	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JT689_RS10850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JT689_RS10855	COG0798	PFAM Bile acid sodium symporter
JT689_RS10930	COG4608	Belongs to the ABC transporter superfamily
JT689_RS10935	COG0444	Belongs to the ABC transporter superfamily
JT689_RS10940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JT689_RS10945	COG0601	transmembrane transport
JT689_RS10955	COG0617	tRNA 3'-terminal CCA addition
JT689_RS10955	COG0517	IMP dehydrogenase activity
JT689_RS10955	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JT689_RS10960	COG0423	glycine-tRNA ligase activity
JT689_RS10970	COG0556	nucleotide-excision repair
JT689_RS10980	COG0601	transmembrane transport
JT689_RS10985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JT689_RS10995	COG4608	Belongs to the ABC transporter superfamily
JT689_RS11005	COG0039	L-malate dehydrogenase activity
JT689_RS11075	COG0322	excinuclease ABC activity
JT689_RS11080	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JT689_RS11085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JT689_RS11085	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JT689_RS11095	COG0589	response to stress
JT689_RS11105	COG0556	nucleotide-excision repair
JT689_RS11130	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
JT689_RS11135	COG3842	ATPase activity
JT689_RS11140	COG2226	methyltransferase
JT689_RS11160	COG0534	Mate efflux family protein
JT689_RS11175	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JT689_RS11215	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JT689_RS11225	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JT689_RS11230	COG2873	o-acetylhomoserine
JT689_RS11235	COG0277	FAD linked oxidase domain protein
JT689_RS11240	COG0560	Phosphoserine phosphatase
JT689_RS11245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JT689_RS11260	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JT689_RS11280	COG0165	Argininosuccinate lyase
JT689_RS11285	COG0137	argininosuccinate synthase activity
JT689_RS11380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JT689_RS11415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JT689_RS11420	COG0822	iron-sulfur transferase activity
JT689_RS11435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JT689_RS11465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JT689_RS11470	COG0581	inorganic phosphate transmembrane transporter activity
JT689_RS11475	COG0573	inorganic phosphate transmembrane transporter activity
JT689_RS11485	COG0702	epimerase
JT689_RS11535	COG0519	Catalyzes the synthesis of GMP from XMP
JT689_RS11535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JT689_RS11540	COG1078	dGTPase activity
JT689_RS11555	COG0167	dihydroorotate dehydrogenase activity
JT689_RS11630	COG0434	BtpA family
JT689_RS11650	COG0456	acetyltransferase
JT689_RS11675	COG0747	negative chemotaxis
JT689_RS11680	COG0601	transmembrane transport
JT689_RS11685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JT689_RS11695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JT689_RS11715	COG1335	isochorismatase
JT689_RS11740	COG2309	aminopeptidase activity
JT689_RS11755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JT689_RS11760	COG1120	ATPase activity
JT689_RS11765	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
JT689_RS11775	COG0633	Ferredoxin
JT689_RS11790	COG1120	ATPase activity
JT689_RS11795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JT689_RS11845	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JT689_RS11880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JT689_RS11895	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
JT689_RS11895	COG0778	Nitroreductase
JT689_RS11900	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JT689_RS11920	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JT689_RS11930	COG0140	phosphoribosyl-ATP diphosphatase activity
JT689_RS11940	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
JT689_RS11955	COG3273	potassium ion transport
JT689_RS11955	COG0471	metal ion transport
JT689_RS11965	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
JT689_RS11970	COG0351	phosphomethylpyrimidine kinase
JT689_RS11980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JT689_RS11995	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JT689_RS12020	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
JT689_RS12035	COG1063	alcohol dehydrogenase
JT689_RS12045	COG0210	DNA helicase
JT689_RS12065	COG2339	peptidase activity
JT689_RS12105	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JT689_RS12165	COG0557	exoribonuclease II activity
JT689_RS12175	COG0051	transcription antitermination factor activity, RNA binding
JT689_RS12180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JT689_RS12185	COG0460	homoserine dehydrogenase
JT689_RS12195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JT689_RS12205	COG0049	tRNA binding
JT689_RS12220	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JT689_RS12225	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JT689_RS12230	COG0085	RNA polymerase activity
JT689_RS12265	COG1309	transcriptional regulator