locus-tag	class	description
HTSR_RS00030	COG0527	aspartate kinase activity
HTSR_RS00035	COG0731	radical SAM domain protein
HTSR_RS00035	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HTSR_RS00050	COG0095	Lipoate-protein ligase
HTSR_RS00055	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HTSR_RS00060	COG3033	Beta-eliminating lyase
HTSR_RS00090	COG0589	response to stress
HTSR_RS00095	COG1757	Na H antiporter
HTSR_RS00100	COG0531	amino acid
HTSR_RS00110	COG2210	Belongs to the sulfur carrier protein TusA family
HTSR_RS00120	COG0306	phosphate transporter
HTSR_RS00135	COG0133	tryptophan synthase activity
HTSR_RS00140	COG1902	pentaerythritol trinitrate reductase activity
HTSR_RS00145	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HTSR_RS00155	COG1141	Ferredoxin
HTSR_RS00195	COG0556	nucleotide-excision repair
HTSR_RS00205	COG0423	glycine-tRNA ligase activity
HTSR_RS00210	COG0517	IMP dehydrogenase activity
HTSR_RS00210	COG0617	tRNA 3'-terminal CCA addition
HTSR_RS00210	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HTSR_RS00220	COG4172	Belongs to the ABC transporter superfamily
HTSR_RS00230	COG0601	transmembrane transport
HTSR_RS00235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HTSR_RS00255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HTSR_RS00285	COG0181	hydroxymethylbilane synthase activity
HTSR_RS00300	COG0113	porphobilinogen synthase activity
HTSR_RS00305	COG2181	nitrate reductase activity
HTSR_RS00305	COG0247	lactate metabolic process
HTSR_RS00320	COG0009	L-threonylcarbamoyladenylate synthase
HTSR_RS00340	COG1253	flavin adenine dinucleotide binding
HTSR_RS00355	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HTSR_RS00365	COG1739	Uncharacterized protein family UPF0029
HTSR_RS00375	COG0131	Imidazoleglycerol-phosphate dehydratase
HTSR_RS00380	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HTSR_RS00395	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HTSR_RS00430	COG0489	protein tyrosine kinase activity
HTSR_RS00455	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HTSR_RS00460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HTSR_RS00470	COG1321	iron dependent repressor
HTSR_RS00530	COG2205	protein histidine kinase activity
HTSR_RS00580	COG1840	ABC-type Fe3 transport system, periplasmic component
HTSR_RS00595	COG0124	histidyl-tRNA synthetase
HTSR_RS00605	COG1164	Oligoendopeptidase f
HTSR_RS00615	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HTSR_RS00620	COG0535	radical SAM domain protein
HTSR_RS00625	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HTSR_RS00630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HTSR_RS00645	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HTSR_RS00665	COG0166	Belongs to the GPI family
HTSR_RS00690	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HTSR_RS00765	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HTSR_RS00770	COG0402	S-adenosylhomocysteine deaminase activity
HTSR_RS00775	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HTSR_RS00785	COG0116	Belongs to the methyltransferase superfamily
HTSR_RS00785	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HTSR_RS00795	COG1234	tRNA 3'-trailer cleavage
HTSR_RS00805	COG0644	oxidoreductase
HTSR_RS00815	COG2086	electron transfer activity
HTSR_RS00830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HTSR_RS00845	COG1185	polyribonucleotide nucleotidyltransferase activity
HTSR_RS00850	COG0459	protein refolding
HTSR_RS00860	COG0495	leucyl-tRNA aminoacylation
HTSR_RS00905	COG0072	phenylalanine-tRNA ligase activity
HTSR_RS00910	COG0167	dihydroorotate dehydrogenase activity
HTSR_RS00945	COG2358	TRAP transporter, solute receptor (TAXI family
HTSR_RS01010	COG3842	ATPase activity
HTSR_RS01020	COG1177	transmembrane transport
HTSR_RS01025	COG4221	oxidoreductase activity
HTSR_RS01060	COG1012	belongs to the aldehyde dehydrogenase family
HTSR_RS01065	COG1028	Short-chain dehydrogenase reductase Sdr
HTSR_RS01085	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HTSR_RS01090	COG0644	oxidoreductase
HTSR_RS01100	COG1028	Short-chain dehydrogenase reductase Sdr
HTSR_RS01130	COG0398	Pfam SNARE associated Golgi protein
HTSR_RS01135	COG1045	serine acetyltransferase
HTSR_RS01165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HTSR_RS01215	COG0733	neurotransmitter:sodium symporter activity
HTSR_RS01270	COG0616	signal peptide processing
HTSR_RS01295	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HTSR_RS01300	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HTSR_RS01310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HTSR_RS01315	COG1278	Cold shock
HTSR_RS01320	COG0277	FAD linked oxidase domain protein
HTSR_RS01325	COG0864	Transcriptional regulator
HTSR_RS01350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HTSR_RS01355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HTSR_RS01360	COG2252	PERMEase
HTSR_RS01380	COG0504	CTP synthase activity
HTSR_RS01385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HTSR_RS01385	COG0519	Catalyzes the synthesis of GMP from XMP
HTSR_RS01400	COG2514	catechol 2,3-dioxygenase activity
HTSR_RS01405	COG0521	Mo-molybdopterin cofactor biosynthetic process
HTSR_RS01410	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HTSR_RS01440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HTSR_RS01445	COG0512	Glutamine amidotransferase of anthranilate synthase
HTSR_RS01450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HTSR_RS01465	COG0446	pyridine nucleotide-disulphide oxidoreductase
HTSR_RS01530	COG0284	orotidine-5'-phosphate decarboxylase activity
HTSR_RS01555	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HTSR_RS01565	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
HTSR_RS01605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HTSR_RS01615	COG0089	rRNA binding
HTSR_RS01620	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HTSR_RS01625	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HTSR_RS01635	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HTSR_RS01640	COG0255	Belongs to the universal ribosomal protein uL29 family
HTSR_RS01650	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HTSR_RS01655	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HTSR_RS01670	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HTSR_RS01680	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HTSR_RS01690	COG0322	excinuclease ABC activity
HTSR_RS01725	COG1473	amidohydrolase
HTSR_RS01750	COG1522	sequence-specific DNA binding
HTSR_RS01760	COG0306	phosphate transporter
HTSR_RS01770	COG0667	Aldo Keto reductase
HTSR_RS01785	COG0490	domain, Protein
HTSR_RS01800	COG2391	methyltransferase activity
HTSR_RS01810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HTSR_RS01810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HTSR_RS01820	COG1131	(ABC) transporter
HTSR_RS01845	COG0473	3-isopropylmalate dehydrogenase activity
HTSR_RS01850	COG0066	3-isopropylmalate dehydratase activity
HTSR_RS01855	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HTSR_RS01860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HTSR_RS01865	COG0440	acetolactate synthase activity
HTSR_RS01875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HTSR_RS01900	COG4191	Histidine kinase
HTSR_RS01915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HTSR_RS01925	COG0358	DNA primase activity
HTSR_RS01935	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HTSR_RS01940	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HTSR_RS01970	COG0435	Glutathione S-transferase
HTSR_RS01980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HTSR_RS01990	COG2154	pterin-4-alpha-carbinolamine dehydratase
HTSR_RS01995	COG0546	phosphoglycolate phosphatase activity
HTSR_RS02000	COG0303	'Molybdopterin
HTSR_RS02010	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HTSR_RS02015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HTSR_RS02025	COG0010	Belongs to the arginase family
HTSR_RS02030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HTSR_RS02060	COG0243	molybdopterin cofactor binding
HTSR_RS02090	COG1253	flavin adenine dinucleotide binding
HTSR_RS02100	COG0531	amino acid
HTSR_RS02110	COG0579	oxidoreductase
HTSR_RS02135	COG0546	phosphoglycolate phosphatase activity
HTSR_RS02170	COG2116	formate transmembrane transporter activity
HTSR_RS02175	COG1028	Short-chain dehydrogenase reductase Sdr
HTSR_RS02180	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HTSR_RS02200	COG2205	protein histidine kinase activity
HTSR_RS02220	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HTSR_RS02225	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HTSR_RS02235	COG0563	adenylate kinase activity
HTSR_RS02245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HTSR_RS02250	COG0569	domain protein
HTSR_RS02285	COG5002	protein histidine kinase activity
HTSR_RS02300	COG0835	chemotaxis
HTSR_RS02300	COG0784	Response regulator, receiver
HTSR_RS02305	COG4191	Histidine kinase
HTSR_RS02310	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HTSR_RS02330	COG0135	phosphoribosylanthranilate isomerase activity
HTSR_RS02335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HTSR_RS02340	COG0512	Glutamine amidotransferase of anthranilate synthase
HTSR_RS02340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HTSR_RS02380	COG0667	Aldo Keto reductase
HTSR_RS02390	COG0697	spore germination
HTSR_RS02395	COG0517	IMP dehydrogenase activity
HTSR_RS02395	COG0516	GMP reductase activity
HTSR_RS02460	COG0509	glycine decarboxylation via glycine cleavage system
HTSR_RS02470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HTSR_RS02475	COG1733	regulation of RNA biosynthetic process
HTSR_RS02485	COG2096	Adenosyltransferase
HTSR_RS02495	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HTSR_RS02515	COG0437	4 iron, 4 sulfur cluster binding
HTSR_RS02520	COG0243	molybdopterin cofactor binding
HTSR_RS02545	COG1047	Peptidyl-prolyl cis-trans
HTSR_RS02580	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HTSR_RS02590	COG0604	alcohol dehydrogenase
HTSR_RS02590	COG3321	synthase
HTSR_RS02600	COG0589	response to stress
HTSR_RS02605	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HTSR_RS02610	COG1078	dGTPase activity
HTSR_RS02615	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HTSR_RS02720	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HTSR_RS02760	COG0456	acetyltransferase
HTSR_RS02760	COG1214	PFAM Peptidase M22, glycoprotease
HTSR_RS02775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HTSR_RS02785	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HTSR_RS02790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HTSR_RS02800	COG0840	transmembrane signaling receptor activity
HTSR_RS02810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HTSR_RS02830	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HTSR_RS02840	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HTSR_RS02890	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HTSR_RS02890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HTSR_RS02895	COG0315	cyclic pyranopterin monophosphate synthase activity
HTSR_RS02900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HTSR_RS02915	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HTSR_RS02945	COG0540	Belongs to the ATCase OTCase family
HTSR_RS02960	COG1047	Peptidyl-prolyl cis-trans
HTSR_RS02975	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
HTSR_RS02980	COG0301	tRNA thio-modification
HTSR_RS02990	COG0151	Belongs to the GarS family
HTSR_RS03005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HTSR_RS03025	COG0189	ligase activity
HTSR_RS03060	COG0798	PFAM Bile acid sodium symporter
HTSR_RS03080	COG0243	molybdopterin cofactor binding
HTSR_RS03085	COG0437	4 iron, 4 sulfur cluster binding
HTSR_RS03100	COG1832	CoA-binding protein
HTSR_RS03135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HTSR_RS03140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HTSR_RS03155	COG1122	ATPase activity
HTSR_RS03175	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HTSR_RS03180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HTSR_RS03190	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HTSR_RS03250	COG0519	Catalyzes the synthesis of GMP from XMP
HTSR_RS03275	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HTSR_RS03280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HTSR_RS03285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HTSR_RS03290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HTSR_RS03305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HTSR_RS03340	COG1435	thymidine kinase activity
HTSR_RS03345	COG0539	negative regulation of cytoplasmic translation
HTSR_RS03370	COG1201	RNA secondary structure unwinding
HTSR_RS03385	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HTSR_RS03390	COG4191	Histidine kinase
HTSR_RS03415	COG0577	efflux transmembrane transporter activity
HTSR_RS03415	COG1136	(ABC) transporter
HTSR_RS03420	COG1136	(ABC) transporter
HTSR_RS03420	COG0577	efflux transmembrane transporter activity
HTSR_RS03430	COG1363	Peptidase, m42
HTSR_RS03440	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HTSR_RS03450	COG1254	Belongs to the acylphosphatase family
HTSR_RS03465	COG0492	ferredoxin-NADP+ reductase activity
HTSR_RS03485	COG0737	Belongs to the 5'-nucleotidase family
HTSR_RS03500	COG0110	maltose O-acetyltransferase activity
HTSR_RS03510	COG0456	acetyltransferase
HTSR_RS03515	COG0126	phosphoglycerate kinase activity
HTSR_RS03525	COG0572	uridine kinase
HTSR_RS03560	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HTSR_RS03565	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HTSR_RS03570	COG0006	proline dipeptidase activity
HTSR_RS03585	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HTSR_RS03595	COG2337	Toxic component of a toxin-antitoxin (TA) module
HTSR_RS03605	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HTSR_RS03620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HTSR_RS03625	COG1201	RNA secondary structure unwinding
HTSR_RS03675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HTSR_RS03700	COG2414	aldehyde ferredoxin oxidoreductase
HTSR_RS03705	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HTSR_RS03715	COG0105	UTP biosynthetic process
HTSR_RS03735	COG1444	tRNA N-acetyltransferase activity
HTSR_RS03740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HTSR_RS03745	COG0142	geranyltranstransferase activity
HTSR_RS03750	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HTSR_RS03755	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HTSR_RS03760	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HTSR_RS03765	COG0052	Belongs to the universal ribosomal protein uS2 family
HTSR_RS03770	COG0148	phosphopyruvate hydratase activity
HTSR_RS03785	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HTSR_RS03790	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HTSR_RS03810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HTSR_RS03820	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HTSR_RS03830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HTSR_RS03835	COG0489	protein tyrosine kinase activity
HTSR_RS03840	COG0674	pyruvate-flavodoxin oxidoreductase activity
HTSR_RS03840	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HTSR_RS03845	COG1013	pyruvate-flavodoxin oxidoreductase activity
HTSR_RS03850	COG1522	sequence-specific DNA binding
HTSR_RS03855	COG0436	Aminotransferase
HTSR_RS03865	COG0295	cytidine deaminase activity
HTSR_RS03900	COG1079	Belongs to the binding-protein-dependent transport system permease family
HTSR_RS03905	COG4603	Belongs to the binding-protein-dependent transport system permease family
HTSR_RS03910	COG3845	ABC transporter
HTSR_RS03915	COG1744	ABC transporter substrate-binding protein PnrA-like
HTSR_RS03920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HTSR_RS03930	COG4962	Type ii secretion system protein e
HTSR_RS03940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HTSR_RS03960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HTSR_RS03970	COG1271	oxidase subunit
HTSR_RS03985	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HTSR_RS03990	COG0492	ferredoxin-NADP+ reductase activity
HTSR_RS04005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HTSR_RS04015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HTSR_RS04020	COG0187	DNA topoisomerase II activity
HTSR_RS04020	COG0187	DNA topoisomerase II activity
HTSR_RS04045	COG3852	Histidine kinase
HTSR_RS04050	COG0346	lactoylglutathione lyase activity
HTSR_RS04060	COG0517	IMP dehydrogenase activity
HTSR_RS04065	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HTSR_RS04085	COG1063	alcohol dehydrogenase
HTSR_RS04165	COG1216	Glycosyl transferase, family 2
HTSR_RS04170	COG1051	belongs to the nudix hydrolase family
HTSR_RS04175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HTSR_RS04190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HTSR_RS04195	COG1216	Glycosyl transferase, family 2
HTSR_RS04205	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HTSR_RS04210	COG0517	IMP dehydrogenase activity
HTSR_RS04210	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HTSR_RS04290	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HTSR_RS04295	COG1132	(ABC) transporter
HTSR_RS04310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HTSR_RS04325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HTSR_RS04345	COG0463	Glycosyl transferase, family 2
HTSR_RS04360	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HTSR_RS04365	COG0179	Fumarylacetoacetate (FAA) hydrolase
HTSR_RS04435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HTSR_RS04445	COG1213	nucleotidyl transferase
HTSR_RS04445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HTSR_RS04460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HTSR_RS04485	COG1116	anion transmembrane transporter activity
HTSR_RS04495	COG0303	'Molybdopterin
HTSR_RS04520	COG1278	Cold shock
HTSR_RS04615	COG0517	IMP dehydrogenase activity
HTSR_RS04615	COG0516	GMP reductase activity
HTSR_RS04665	COG0857	belongs to the CobB CobQ family
HTSR_RS04675	COG3273	potassium ion transport
HTSR_RS04675	COG0471	metal ion transport
HTSR_RS04685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HTSR_RS04715	COG0445	tRNA wobble uridine modification
HTSR_RS04730	COG0443	Heat shock 70 kDa protein
HTSR_RS04735	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HTSR_RS04750	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HTSR_RS04750	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HTSR_RS04760	COG0436	Aminotransferase
HTSR_RS04770	COG0012	GTP binding
HTSR_RS04785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HTSR_RS04795	COG0419	ATPase involved in DNA repair
HTSR_RS04825	COG0300	oxidoreductase activity
HTSR_RS04830	COG0396	ATPase activity
HTSR_RS04835	COG0719	Fe-S assembly protein
HTSR_RS04840	COG0719	Fe-S assembly protein
HTSR_RS04865	COG0668	transmembrane transport
HTSR_RS04870	COG1757	Na H antiporter
HTSR_RS04880	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HTSR_RS04880	COG0517	IMP dehydrogenase activity
HTSR_RS04880	COG0617	tRNA 3'-terminal CCA addition
HTSR_RS04885	COG1278	Cold shock
HTSR_RS04895	COG1280	lysine exporter protein (LysE YggA)
HTSR_RS04900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HTSR_RS04910	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HTSR_RS04920	COG0765	amino acid transport
HTSR_RS04930	COG0765	amino acid transport
HTSR_RS04955	COG1185	polyribonucleotide nucleotidyltransferase activity
HTSR_RS04990	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HTSR_RS04995	COG1863	multisubunit Na H antiporter MnhE subunit
HTSR_RS05000	COG2212	antiporter activity
HTSR_RS05005	COG1320	monovalent cation:proton antiporter activity
HTSR_RS05010	COG2111	Na H antiporter
HTSR_RS05010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HTSR_RS05020	COG1006	Multisubunit Na H antiporter MnhC subunit
HTSR_RS05025	COG0651	ATP synthesis coupled electron transport
HTSR_RS05030	COG0651	ATP synthesis coupled electron transport
HTSR_RS05035	COG0651	ATP synthesis coupled electron transport
HTSR_RS05040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HTSR_RS05060	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HTSR_RS05065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HTSR_RS05085	COG0163	prenyltransferase activity
HTSR_RS05115	COG0709	Synthesizes selenophosphate from selenide and ATP
HTSR_RS05140	COG1139	Iron-sulfur cluster binding protein
HTSR_RS05145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HTSR_RS05150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HTSR_RS05155	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HTSR_RS05165	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HTSR_RS05200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HTSR_RS05205	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HTSR_RS05210	COG0081	regulation of translation
HTSR_RS05235	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HTSR_RS05240	COG0697	spore germination
HTSR_RS05255	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HTSR_RS05270	COG0114	fumarate hydratase activity
HTSR_RS05285	COG2226	methyltransferase
HTSR_RS05310	COG0459	protein refolding
HTSR_RS05315	COG2078	PFAM AMMECR1 domain protein
HTSR_RS05320	COG1355	regulation of microtubule-based process
HTSR_RS05325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HTSR_RS05335	COG3118	belongs to the thioredoxin family
HTSR_RS05345	COG0446	pyridine nucleotide-disulphide oxidoreductase
HTSR_RS05360	COG0450	alkyl hydroperoxide reductase
HTSR_RS05365	COG0415	Belongs to the DNA photolyase family
HTSR_RS05370	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HTSR_RS05395	COG2130	NADP-dependent
HTSR_RS05405	COG2226	methyltransferase
HTSR_RS05405	COG1073	alpha beta
HTSR_RS05410	COG0129	dihydroxy-acid dehydratase activity
HTSR_RS05430	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HTSR_RS05445	COG4191	Histidine kinase
HTSR_RS05455	COG0589	response to stress
HTSR_RS05465	COG0668	transmembrane transport
HTSR_RS05470	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HTSR_RS05470	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HTSR_RS05505	COG1058	Belongs to the CinA family
HTSR_RS05505	COG1546	Belongs to the CinA family
HTSR_RS05570	COG0430	RNA-3'-phosphate cyclase activity
HTSR_RS05580	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HTSR_RS05585	COG0561	phosphatase activity
HTSR_RS05650	COG2217	Heavy metal translocating P-type atpase
HTSR_RS05655	COG2217	Heavy metal translocating P-type atpase
HTSR_RS05680	COG1830	Aldolase
HTSR_RS05700	COG2239	Acts as a magnesium transporter
HTSR_RS05710	COG0436	Aminotransferase
HTSR_RS05720	COG1007	ATP synthesis coupled electron transport
HTSR_RS05745	COG0839	Belongs to the complex I subunit 6 family
HTSR_RS05750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HTSR_RS05755	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HTSR_RS05760	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HTSR_RS05760	COG0649	NAD binding
HTSR_RS05765	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HTSR_RS05770	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HTSR_RS05785	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HTSR_RS05795	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HTSR_RS05800	COG0436	Aminotransferase
HTSR_RS05805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HTSR_RS05825	COG0438	transferase activity, transferring glycosyl groups
HTSR_RS05845	COG0668	transmembrane transport
HTSR_RS05860	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HTSR_RS05885	COG2827	Endonuclease containing a URI domain
HTSR_RS05940	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HTSR_RS05955	COG0129	dihydroxy-acid dehydratase activity
HTSR_RS05985	COG3920	Histidine kinase
HTSR_RS05985	COG2202	Pas domain
HTSR_RS06000	COG1216	Glycosyl transferase, family 2
HTSR_RS06025	COG0534	Mate efflux family protein
HTSR_RS06030	COG0589	response to stress
HTSR_RS06040	COG0442	prolyl-tRNA aminoacylation
HTSR_RS06060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HTSR_RS06115	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HTSR_RS06120	COG3174	membrane
HTSR_RS06125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HTSR_RS06155	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HTSR_RS06160	COG1525	nuclease
HTSR_RS06165	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HTSR_RS06175	COG1321	iron dependent repressor
HTSR_RS06180	COG2119	membrane
HTSR_RS06190	COG0534	Mate efflux family protein
HTSR_RS06210	COG0442	prolyl-tRNA aminoacylation
HTSR_RS06220	COG1028	Short-chain dehydrogenase reductase Sdr
HTSR_RS06260	COG0215	cysteine-tRNA ligase activity
HTSR_RS06280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HTSR_RS06315	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HTSR_RS06320	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HTSR_RS06325	COG1575	Belongs to the MenA family. Type 1 subfamily
HTSR_RS06335	COG0318	PFAM AMP-dependent synthetase and ligase
HTSR_RS06345	COG0154	amidase activity
HTSR_RS06350	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HTSR_RS06355	COG0587	DNA-directed DNA polymerase activity
HTSR_RS06360	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HTSR_RS06405	COG0704	Plays a role in the regulation of phosphate uptake
HTSR_RS06435	COG1051	belongs to the nudix hydrolase family
HTSR_RS06495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HTSR_RS06500	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HTSR_RS06510	COG0019	diaminopimelate decarboxylase activity
HTSR_RS06515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HTSR_RS06520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HTSR_RS06535	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HTSR_RS06540	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HTSR_RS06550	COG0516	GMP reductase activity
HTSR_RS06550	COG0517	IMP dehydrogenase activity
HTSR_RS06555	COG0371	Dehydrogenase
HTSR_RS06580	COG0437	4 iron, 4 sulfur cluster binding
HTSR_RS06630	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HTSR_RS06635	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HTSR_RS06645	COG2894	cell division
HTSR_RS06665	COG0840	transmembrane signaling receptor activity
HTSR_RS06690	COG2201	protein-glutamate methylesterase activity
HTSR_RS06695	COG2201	protein-glutamate methylesterase activity
HTSR_RS06700	COG2198	Histidine kinase
HTSR_RS06700	COG0643	Histidine kinase
HTSR_RS06715	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HTSR_RS06720	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HTSR_RS06770	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HTSR_RS06810	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HTSR_RS06825	COG1234	tRNA 3'-trailer cleavage
HTSR_RS06830	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HTSR_RS06860	COG0003	Pfam Anion-transporting ATPase
HTSR_RS06865	COG2379	hydroxypyruvate reductase
HTSR_RS06870	COG0300	oxidoreductase activity
HTSR_RS06875	COG1515	deoxyribonuclease V activity
HTSR_RS06890	COG1796	DNA polymerase
HTSR_RS06890	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HTSR_RS06920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HTSR_RS06930	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HTSR_RS06940	COG1196	nuclear chromosome segregation
HTSR_RS06945	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HTSR_RS06950	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HTSR_RS06955	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HTSR_RS06970	COG0501	Belongs to the peptidase M48B family
HTSR_RS06990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HTSR_RS06990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HTSR_RS06995	COG0469	pyruvate kinase activity
HTSR_RS07005	COG0330	HflC and HflK could
HTSR_RS07020	COG1216	Glycosyl transferase, family 2
HTSR_RS07040	COG1465	3-dehydroquinate synthase
HTSR_RS07045	COG1830	Aldolase
HTSR_RS07050	COG0159	tryptophan synthase activity
HTSR_RS07055	COG0133	tryptophan synthase activity
HTSR_RS07075	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HTSR_RS07100	COG2226	methyltransferase
HTSR_RS07120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HTSR_RS07195	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HTSR_RS07210	COG0328	RNA-DNA hybrid ribonuclease activity
HTSR_RS07220	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HTSR_RS07225	COG0017	Asparaginyl-tRNA synthetase
HTSR_RS07245	COG0717	Belongs to the dCTP deaminase family
HTSR_RS07255	COG0585	pseudouridine synthase activity
HTSR_RS07260	COG1253	flavin adenine dinucleotide binding
HTSR_RS07285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HTSR_RS07320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HTSR_RS07325	COG1012	belongs to the aldehyde dehydrogenase family
HTSR_RS07365	COG1764	response to oxidative stress
HTSR_RS07380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HTSR_RS07385	COG0037	tRNA processing
HTSR_RS07400	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HTSR_RS07425	COG1793	dna ligase
HTSR_RS07465	COG0437	4 iron, 4 sulfur cluster binding
HTSR_RS07475	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HTSR_RS07485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HTSR_RS07490	COG0049	tRNA binding
HTSR_RS07505	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HTSR_RS07510	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HTSR_RS07515	COG0085	RNA polymerase activity
HTSR_RS07520	COG0085	RNA polymerase activity
HTSR_RS07585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HTSR_RS07635	COG0745	RESPONSE REGULATOR receiver
HTSR_RS07645	COG0460	homoserine dehydrogenase
HTSR_RS07650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HTSR_RS07655	COG0051	transcription antitermination factor activity, RNA binding
HTSR_RS07710	COG0437	4 iron, 4 sulfur cluster binding
HTSR_RS07715	COG3383	formate dehydrogenase (NAD+) activity
HTSR_RS07725	COG0717	Belongs to the dCTP deaminase family
HTSR_RS07750	COG0557	exoribonuclease II activity
HTSR_RS07780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HTSR_RS07795	COG1458	PINc domain ribonuclease
HTSR_RS07800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HTSR_RS07805	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HTSR_RS07825	COG2339	peptidase activity
HTSR_RS07835	COG0210	DNA helicase
HTSR_RS07860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HTSR_RS07885	COG3118	belongs to the thioredoxin family
HTSR_RS07885	COG0492	ferredoxin-NADP+ reductase activity
HTSR_RS07905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HTSR_RS07915	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HTSR_RS07920	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HTSR_RS07935	COG0640	Transcriptional regulator
HTSR_RS07945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HTSR_RS07965	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HTSR_RS07970	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HTSR_RS07975	COG0525	valine-tRNA ligase activity
HTSR_RS07990	COG0725	ABC transporter, periplasmic molybdate-binding protein
HTSR_RS08030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HTSR_RS08045	COG0456	acetyltransferase
HTSR_RS08075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HTSR_RS08090	COG3177	Filamentation induced by cAMP protein fic
HTSR_RS08120	COG0437	4 iron, 4 sulfur cluster binding
HTSR_RS08160	COG0156	8-amino-7-oxononanoate synthase activity
HTSR_RS08180	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HTSR_RS08185	COG2746	aminoglycoside 3-N-acetyltransferase activity
HTSR_RS08190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HTSR_RS08195	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HTSR_RS08220	COG0095	Lipoate-protein ligase
HTSR_RS08240	COG1028	Short-chain dehydrogenase reductase Sdr
HTSR_RS08245	COG4191	Histidine kinase
HTSR_RS08255	COG2873	o-acetylhomoserine
HTSR_RS08310	COG0437	4 iron, 4 sulfur cluster binding
HTSR_RS08375	COG1410	methionine synthase
HTSR_RS08375	COG0646	methionine synthase
HTSR_RS08400	COG1414	Transcriptional regulator
HTSR_RS08420	COG1473	amidohydrolase
HTSR_RS08455	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HTSR_RS08455	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HTSR_RS08500	COG3383	formate dehydrogenase (NAD+) activity
HTSR_RS08510	COG5598	trimethylamine methyltransferase
HTSR_RS08515	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HTSR_RS08520	COG3383	formate dehydrogenase (NAD+) activity
HTSR_RS08535	COG3608	succinylglutamate desuccinylase aspartoacylase
HTSR_RS08545	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
HTSR_RS08555	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HTSR_RS08560	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HTSR_RS08580	COG5012	cobalamin binding
HTSR_RS08585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HTSR_RS08590	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HTSR_RS08595	COG1546	Belongs to the CinA family
HTSR_RS08595	COG1058	Belongs to the CinA family
HTSR_RS08620	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HTSR_RS08630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HTSR_RS08640	COG1492	cobalamin metabolic process
HTSR_RS08650	COG0702	epimerase
HTSR_RS08665	COG1132	(ABC) transporter
HTSR_RS08690	COG3253	May function as heme-dependent peroxidase
HTSR_RS08700	COG1122	ATPase activity
HTSR_RS08705	COG1122	ATPase activity
HTSR_RS08780	COG1151	hydroxylamine reductase activity
HTSR_RS08790	COG1063	alcohol dehydrogenase
HTSR_RS08805	COG0731	radical SAM domain protein
HTSR_RS08815	COG2894	cell division
HTSR_RS08830	COG2204	response regulator
HTSR_RS08845	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HTSR_RS08880	COG1269	ATP hydrolysis coupled proton transport
HTSR_RS08920	COG0142	geranyltranstransferase activity
HTSR_RS08940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HTSR_RS08945	COG1469	GTP cyclohydrolase I activity
HTSR_RS08965	COG0864	Transcriptional regulator
HTSR_RS08985	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HTSR_RS09005	COG1648	precorrin-2 dehydrogenase activity
HTSR_RS09005	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HTSR_RS09010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HTSR_RS09010	COG1648	precorrin-2 dehydrogenase activity
HTSR_RS09015	COG0310	cobalt ion transport
HTSR_RS09020	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
HTSR_RS09030	COG1122	ATPase activity
HTSR_RS09065	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HTSR_RS09080	COG2082	Precorrin-8x methylmutase
HTSR_RS09100	COG1116	anion transmembrane transporter activity
HTSR_RS09115	COG1446	asparaginase
HTSR_RS09120	COG0024	Methionine aminopeptidase
HTSR_RS09145	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HTSR_RS09155	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HTSR_RS09180	COG0252	asparaginase activity
HTSR_RS09195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HTSR_RS09220	COG3608	succinylglutamate desuccinylase aspartoacylase
HTSR_RS09230	COG0372	Belongs to the citrate synthase family
HTSR_RS09235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HTSR_RS09255	COG0459	protein refolding
HTSR_RS09295	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
HTSR_RS09305	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HTSR_RS09325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HTSR_RS09345	COG0385	Bile acid
HTSR_RS09350	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HTSR_RS09355	COG4191	Histidine kinase
HTSR_RS09375	COG0464	growth
HTSR_RS09380	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HTSR_RS09380	COG0321	lipoyl(octanoyl) transferase activity
HTSR_RS09405	COG0557	exoribonuclease II activity
HTSR_RS09430	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HTSR_RS09440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HTSR_RS09450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HTSR_RS09470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HTSR_RS09475	COG0573	inorganic phosphate transmembrane transporter activity
HTSR_RS09480	COG0581	inorganic phosphate transmembrane transporter activity
HTSR_RS09485	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HTSR_RS09495	COG0346	lactoylglutathione lyase activity
HTSR_RS09520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HTSR_RS09535	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HTSR_RS09550	COG0023	Translation Initiation Factor
HTSR_RS09555	COG0784	Response regulator, receiver
HTSR_RS09555	COG4191	Histidine kinase
HTSR_RS09580	COG0528	UMP kinase activity
HTSR_RS09585	COG0314	molybdopterin synthase activity
HTSR_RS09595	COG0494	nUDIX hydrolase
HTSR_RS09600	COG0343	queuine tRNA-ribosyltransferase activity
HTSR_RS09635	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HTSR_RS09640	COG2414	aldehyde ferredoxin oxidoreductase
HTSR_RS09650	COG0047	phosphoribosylformylglycinamidine synthase activity
HTSR_RS09655	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HTSR_RS09660	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HTSR_RS09665	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HTSR_RS09670	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HTSR_RS09685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HTSR_RS09690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HTSR_RS09695	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HTSR_RS09755	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HTSR_RS09775	COG0805	protein transport
HTSR_RS09790	COG0733	neurotransmitter:sodium symporter activity
HTSR_RS09820	COG0151	Belongs to the GarS family
HTSR_RS09835	COG0688	phosphatidylethanolamine metabolic process
HTSR_RS09840	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HTSR_RS09850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HTSR_RS09855	COG0668	transmembrane transport
HTSR_RS09880	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HTSR_RS09895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HTSR_RS09905	COG0501	Belongs to the peptidase M48B family
HTSR_RS09925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HTSR_RS09925	COG0425	Belongs to the sulfur carrier protein TusA family
HTSR_RS09930	COG1252	NADH dehydrogenase
HTSR_RS09940	COG0822	iron-sulfur transferase activity
HTSR_RS09945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HTSR_RS10080	COG0137	argininosuccinate synthase activity
HTSR_RS10085	COG0165	Argininosuccinate lyase
HTSR_RS10095	COG0189	ligase activity
HTSR_RS10100	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HTSR_RS10105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HTSR_RS10115	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HTSR_RS10125	COG0322	excinuclease ABC activity
HTSR_RS10130	COG2329	Antibiotic biosynthesis monooxygenase
HTSR_RS10135	COG0556	nucleotide-excision repair
HTSR_RS10150	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HTSR_RS10155	COG3842	ATPase activity
HTSR_RS10160	COG4106	trans-aconitate 2-methyltransferase activity
HTSR_RS10180	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HTSR_RS10200	COG1902	pentaerythritol trinitrate reductase activity
HTSR_RS10200	COG0446	pyridine nucleotide-disulphide oxidoreductase
HTSR_RS10215	COG1215	transferase activity, transferring glycosyl groups
HTSR_RS10260	COG5002	protein histidine kinase activity
HTSR_RS10295	COG0297	glycogen (starch) synthase activity
HTSR_RS10300	COG3119	arylsulfatase activity
HTSR_RS10390	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family