locus-tag	class	description
E5139_RS00095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E5139_RS00120	COG0733	neurotransmitter:sodium symporter activity
E5139_RS00130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E5139_RS00135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5139_RS00145	COG4770	biotin carboxylase activity
E5139_RS00150	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E5139_RS00150	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E5139_RS00155	COG0589	response to stress
E5139_RS00165	COG1078	dGTPase activity
E5139_RS00175	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E5139_RS00210	COG0489	protein tyrosine kinase activity
E5139_RS00225	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E5139_RS00230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E5139_RS00235	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E5139_RS00260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E5139_RS00280	COG0052	Belongs to the universal ribosomal protein uS2 family
E5139_RS00295	COG2124	cytochrome p450
E5139_RS00330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5139_RS00335	COG0657	acetylesterase activity
E5139_RS00355	COG0644	oxidoreductase
E5139_RS00375	COG1444	tRNA N-acetyltransferase activity
E5139_RS00395	COG0105	UTP biosynthetic process
E5139_RS00465	COG2706	6-phosphogluconolactonase activity
E5139_RS00475	COG0517	IMP dehydrogenase activity
E5139_RS00485	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E5139_RS00490	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E5139_RS00545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5139_RS00550	COG0028	Belongs to the TPP enzyme family
E5139_RS00555	COG0440	acetolactate synthase activity
E5139_RS00560	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E5139_RS00570	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5139_RS00575	COG0066	3-isopropylmalate dehydratase activity
E5139_RS00585	COG0473	3-isopropylmalate dehydrogenase activity
E5139_RS00590	COG1349	DNA-binding transcription factor activity
E5139_RS00595	COG1105	Belongs to the carbohydrate kinase PfkB family
E5139_RS00605	COG1830	Aldolase
E5139_RS00640	COG2264	protein methyltransferase activity
E5139_RS00645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5139_RS00680	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5139_RS00705	COG1028	Short-chain dehydrogenase reductase Sdr
E5139_RS00710	COG0450	alkyl hydroperoxide reductase
E5139_RS00715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5139_RS00745	COG3046	protein related to deoxyribodipyrimidine photolyase
E5139_RS00750	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5139_RS00760	COG2217	Heavy metal translocating P-type atpase
E5139_RS00785	COG0693	protein deglycase activity
E5139_RS00790	COG0647	UMP catabolic process
E5139_RS00795	COG0642	Histidine kinase
E5139_RS00805	COG1131	(ABC) transporter
E5139_RS00820	COG3361	conserved protein (COG2071)
E5139_RS00830	COG0667	Aldo Keto reductase
E5139_RS00845	COG1131	(ABC) transporter
E5139_RS00865	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E5139_RS00880	COG2337	Toxic component of a toxin-antitoxin (TA) module
E5139_RS00895	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E5139_RS00910	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
E5139_RS00920	COG1793	dna ligase
E5139_RS00925	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E5139_RS00950	COG0187	DNA topoisomerase II activity
E5139_RS00955	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E5139_RS00985	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5139_RS00995	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
E5139_RS01000	COG0295	cytidine deaminase activity
E5139_RS01005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5139_RS01025	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E5139_RS01060	COG1215	transferase activity, transferring glycosyl groups
E5139_RS01065	COG0438	transferase activity, transferring glycosyl groups
E5139_RS01070	COG3119	arylsulfatase activity
E5139_RS01080	COG0438	transferase activity, transferring glycosyl groups
E5139_RS01090	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E5139_RS01105	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E5139_RS01135	COG1028	Short-chain dehydrogenase reductase Sdr
E5139_RS01140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5139_RS01150	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E5139_RS01175	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5139_RS01185	COG0114	fumarate hydratase activity
E5139_RS01190	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5139_RS01190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5139_RS01250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5139_RS01255	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E5139_RS01270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5139_RS01280	COG0109	protoheme IX farnesyltransferase activity
E5139_RS01315	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5139_RS01315	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5139_RS01320	COG1703	isobutyryl-CoA mutase activity
E5139_RS01325	COG2267	carboxylic ester hydrolase activity
E5139_RS01350	COG2205	protein histidine kinase activity
E5139_RS01355	COG0012	GTP binding
E5139_RS01390	COG0436	Aminotransferase
E5139_RS01415	COG0616	signal peptide processing
E5139_RS01465	COG1518	maintenance of DNA repeat elements
E5139_RS01470	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E5139_RS01500	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E5139_RS01505	COG0443	Heat shock 70 kDa protein
E5139_RS01515	COG0656	L-ascorbic acid biosynthetic process
E5139_RS01525	COG0484	heat shock protein binding
E5139_RS01555	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5139_RS01560	COG1863	multisubunit Na H antiporter MnhE subunit
E5139_RS01570	COG1320	monovalent cation:proton antiporter activity
E5139_RS01580	COG2111	Na H antiporter
E5139_RS01585	COG1006	Multisubunit Na H antiporter MnhC subunit
E5139_RS01590	COG0651	ATP synthesis coupled electron transport
E5139_RS01595	COG0651	ATP synthesis coupled electron transport
E5139_RS01600	COG0651	ATP synthesis coupled electron transport
E5139_RS01630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5139_RS01695	COG0484	heat shock protein binding
E5139_RS01710	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5139_RS01715	COG0346	lactoylglutathione lyase activity
E5139_RS01725	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5139_RS01725	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5139_RS01740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5139_RS01750	COG0417	DNA replication proofreading
E5139_RS01770	COG0419	ATPase involved in DNA repair
E5139_RS01790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5139_RS01820	COG1960	acyl-CoA dehydrogenase activity
E5139_RS01825	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5139_RS01830	COG1830	Aldolase
E5139_RS01835	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E5139_RS01840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5139_RS01865	COG0396	ATPase activity
E5139_RS01870	COG0719	Fe-S assembly protein
E5139_RS01875	COG0719	Fe-S assembly protein
E5139_RS01925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5139_RS01925	COG0512	Glutamine amidotransferase of anthranilate synthase
E5139_RS01930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E5139_RS01935	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E5139_RS01935	COG3743	rRNA binding
E5139_RS01950	COG1234	tRNA 3'-trailer cleavage
E5139_RS01955	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E5139_RS01985	COG1131	(ABC) transporter
E5139_RS02025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5139_RS02035	COG0701	Predicted permease
E5139_RS02080	COG1546	Belongs to the CinA family
E5139_RS02080	COG1058	Belongs to the CinA family
E5139_RS02090	COG0436	Aminotransferase
E5139_RS02110	COG1515	deoxyribonuclease V activity
E5139_RS02120	COG0300	oxidoreductase activity
E5139_RS02155	COG2205	protein histidine kinase activity
E5139_RS02170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5139_RS02180	COG4865	methylaspartate mutase activity
E5139_RS02185	COG3799	methylaspartate ammonia-lyase activity
E5139_RS02205	COG1796	DNA polymerase
E5139_RS02205	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E5139_RS02225	COG0330	HflC and HflK could
E5139_RS02240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5139_RS02240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5139_RS02280	COG1196	nuclear chromosome segregation
E5139_RS02295	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5139_RS02300	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E5139_RS02320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5139_RS02370	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E5139_RS02385	COG4555	ABC transporter
E5139_RS02405	COG0442	prolyl-tRNA aminoacylation
E5139_RS02410	COG0463	Glycosyl transferase, family 2
E5139_RS02440	COG1465	3-dehydroquinate synthase
E5139_RS02445	COG1830	Aldolase
E5139_RS02450	COG0159	tryptophan synthase activity
E5139_RS02455	COG0133	tryptophan synthase activity
E5139_RS02460	COG0134	indole-3-glycerol-phosphate synthase activity
E5139_RS02485	COG0017	Asparaginyl-tRNA synthetase
E5139_RS02510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5139_RS02560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E5139_RS02570	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E5139_RS02615	COG0667	Aldo Keto reductase
E5139_RS02635	COG3250	beta-galactosidase activity
E5139_RS02680	COG0674	pyruvate-flavodoxin oxidoreductase activity
E5139_RS02680	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E5139_RS02685	COG1013	pyruvate-flavodoxin oxidoreductase activity
E5139_RS02705	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E5139_RS02725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E5139_RS02730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E5139_RS02760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E5139_RS02770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5139_RS02785	COG1960	acyl-CoA dehydrogenase activity
E5139_RS02815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5139_RS02820	COG2301	Belongs to the HpcH HpaI aldolase family
E5139_RS02885	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E5139_RS02900	COG0442	prolyl-tRNA aminoacylation
E5139_RS02910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5139_RS02915	COG0070	glutamate synthase
E5139_RS02915	COG0069	glutamate synthase activity
E5139_RS02915	COG0067	glutamate synthase
E5139_RS02930	COG0371	Dehydrogenase
E5139_RS02940	COG1505	serine-type exopeptidase activity
E5139_RS02970	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E5139_RS02975	COG3325	Belongs to the glycosyl hydrolase 18 family
E5139_RS02975	COG3469	chitinase activity
E5139_RS02990	COG4191	Histidine kinase
E5139_RS03015	COG2339	peptidase activity
E5139_RS03020	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E5139_RS03035	COG0477	Major facilitator Superfamily
E5139_RS03060	COG0019	diaminopimelate decarboxylase activity
E5139_RS03070	COG2171	N-acyltransferase activity
E5139_RS03080	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E5139_RS03085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5139_RS03100	COG1472	Belongs to the glycosyl hydrolase 3 family
E5139_RS03105	COG1744	ABC transporter substrate-binding protein PnrA-like
E5139_RS03110	COG3845	ABC transporter
E5139_RS03115	COG4603	Belongs to the binding-protein-dependent transport system permease family
E5139_RS03120	COG1079	Belongs to the binding-protein-dependent transport system permease family
E5139_RS03150	COG2264	protein methyltransferase activity
E5139_RS03225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E5139_RS03245	COG0459	protein refolding
E5139_RS03270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5139_RS03295	COG0577	efflux transmembrane transporter activity
E5139_RS03300	COG1136	(ABC) transporter
E5139_RS03320	COG2814	Major facilitator Superfamily
E5139_RS03330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5139_RS03335	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
E5139_RS03370	COG0656	L-ascorbic acid biosynthetic process
E5139_RS03410	COG0585	pseudouridine synthase activity
E5139_RS03420	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
E5139_RS03430	COG0717	Belongs to the dCTP deaminase family
E5139_RS03440	COG2226	methyltransferase
E5139_RS03450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5139_RS03470	COG0519	Catalyzes the synthesis of GMP from XMP
E5139_RS03470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5139_RS03490	COG0714	Associated with various cellular activities
E5139_RS03530	COG1169	isochorismate synthase
E5139_RS03550	COG4608	Belongs to the ABC transporter superfamily
E5139_RS03555	COG0444	Belongs to the ABC transporter superfamily
E5139_RS03560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5139_RS03565	COG0601	transmembrane transport
E5139_RS03575	COG0366	Alpha amylase catalytic
E5139_RS03580	COG0366	Alpha amylase catalytic
E5139_RS03620	COG1136	(ABC) transporter
E5139_RS03660	COG0438	transferase activity, transferring glycosyl groups
E5139_RS03690	COG0438	transferase activity, transferring glycosyl groups
E5139_RS03715	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E5139_RS03725	COG1216	Glycosyl transferase, family 2
E5139_RS03760	COG0714	Associated with various cellular activities
E5139_RS03785	COG4948	Mandelate Racemase Muconate Lactonizing
E5139_RS03790	COG1414	Transcriptional regulator
E5139_RS03795	COG0457	Tetratricopeptide repeat
E5139_RS03835	COG0733	neurotransmitter:sodium symporter activity
E5139_RS03840	COG0483	inositol monophosphate 1-phosphatase activity
E5139_RS03855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5139_RS03860	COG0601	transmembrane transport
E5139_RS03885	COG4948	Mandelate Racemase Muconate Lactonizing
E5139_RS03895	COG4948	Mandelate Racemase Muconate Lactonizing
E5139_RS03910	COG0318	PFAM AMP-dependent synthetase and ligase
E5139_RS03915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5139_RS03970	COG0489	protein tyrosine kinase activity
E5139_RS03990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5139_RS03995	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E5139_RS04000	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E5139_RS04005	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E5139_RS04015	COG0667	Aldo Keto reductase
E5139_RS04030	COG0463	Glycosyl transferase, family 2
E5139_RS04135	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E5139_RS04160	COG0037	tRNA processing
E5139_RS04195	COG4106	trans-aconitate 2-methyltransferase activity
E5139_RS04205	COG5002	protein histidine kinase activity
E5139_RS04210	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E5139_RS04220	COG0095	Lipoate-protein ligase
E5139_RS04235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5139_RS04260	COG0531	amino acid
E5139_RS04275	COG0616	signal peptide processing
E5139_RS04280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5139_RS04295	COG1335	isochorismatase
E5139_RS04305	COG3833	ABC-type maltose transport systems, permease component
E5139_RS04310	COG1175	transmembrane transport
E5139_RS04345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E5139_RS04360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5139_RS04365	COG0601	transmembrane transport
E5139_RS04370	COG0747	negative chemotaxis
E5139_RS04375	COG4172	Belongs to the ABC transporter superfamily
E5139_RS04395	COG0454	-acetyltransferase
E5139_RS04395	COG0456	acetyltransferase
E5139_RS04435	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E5139_RS04455	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E5139_RS04465	COG2201	protein-glutamate methylesterase activity
E5139_RS04510	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
E5139_RS04520	COG2201	protein-glutamate methylesterase activity
E5139_RS04525	COG2198	Histidine kinase
E5139_RS04525	COG0643	Histidine kinase
E5139_RS04530	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E5139_RS04575	COG0840	transmembrane signaling receptor activity
E5139_RS04600	COG0667	Aldo Keto reductase
E5139_RS04615	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E5139_RS04645	COG0557	exoribonuclease II activity
E5139_RS04675	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E5139_RS04690	COG0251	oxidation-reduction process
E5139_RS04705	COG2202	Pas domain
E5139_RS04705	COG1366	Belongs to the anti-sigma-factor antagonist family
E5139_RS04715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5139_RS04735	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
E5139_RS04745	COG1122	ATPase activity
E5139_RS04760	COG0310	cobalt ion transport
E5139_RS04765	COG0864	Transcriptional regulator
E5139_RS04830	COG3118	belongs to the thioredoxin family
E5139_RS04860	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5139_RS04870	COG1082	Xylose isomerase domain protein TIM barrel
E5139_RS04875	COG4948	Mandelate Racemase Muconate Lactonizing
E5139_RS04880	COG0673	inositol 2-dehydrogenase activity
E5139_RS04890	COG1012	belongs to the aldehyde dehydrogenase family
E5139_RS04895	COG0028	Belongs to the TPP enzyme family
E5139_RS04900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5139_RS04905	COG1414	Transcriptional regulator
E5139_RS04910	COG0584	glycerophosphoryl diester phosphodiesterase
E5139_RS04915	COG3842	ATPase activity
E5139_RS04920	COG0395	ABC-type sugar transport system, permease component
E5139_RS04935	COG1285	pathogenesis
E5139_RS04965	COG1278	Cold shock
E5139_RS04975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5139_RS04980	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
E5139_RS04980	COG0778	Nitroreductase
E5139_RS05020	COG1126	abc transporter atp-binding protein
E5139_RS05040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E5139_RS05050	COG0573	inorganic phosphate transmembrane transporter activity
E5139_RS05060	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E5139_RS05080	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E5139_RS05090	COG0351	phosphomethylpyrimidine kinase
E5139_RS05100	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E5139_RS05135	COG0501	Belongs to the peptidase M48B family
E5139_RS05150	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E5139_RS05160	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E5139_RS05195	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5139_RS05210	COG0783	Belongs to the Dps family
E5139_RS05225	COG0492	ferredoxin-NADP+ reductase activity
E5139_RS05235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5139_RS05245	COG0702	epimerase
E5139_RS05265	COG1132	(ABC) transporter
E5139_RS05270	COG0352	thiamine-phosphate diphosphorylase activity
E5139_RS05305	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
E5139_RS05325	COG2234	aminopeptidase activity
E5139_RS05335	COG1132	(ABC) transporter
E5139_RS05340	COG4191	Histidine kinase
E5139_RS05400	COG1476	TRANSCRIPTIONal
E5139_RS05420	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5139_RS05440	COG0656	L-ascorbic acid biosynthetic process
E5139_RS05590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5139_RS05595	COG0460	homoserine dehydrogenase
E5139_RS05615	COG4251	negative regulation of phosphorylation
E5139_RS05625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E5139_RS05640	COG1122	ATPase activity
E5139_RS05645	COG1268	BioY protein
E5139_RS05650	COG0049	tRNA binding
E5139_RS05665	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E5139_RS05670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E5139_RS05675	COG0085	RNA polymerase activity
E5139_RS05710	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5139_RS05715	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5139_RS05725	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E5139_RS05730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E5139_RS05760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E5139_RS05785	COG0126	phosphoglycerate kinase activity
E5139_RS05800	COG4608	Belongs to the ABC transporter superfamily
E5139_RS05805	COG0444	Belongs to the ABC transporter superfamily
E5139_RS05810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5139_RS05815	COG0601	transmembrane transport
E5139_RS05850	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E5139_RS05865	COG0140	phosphoribosyl-ATP diphosphatase activity
E5139_RS05880	COG2339	peptidase activity
E5139_RS05905	COG0210	DNA helicase
E5139_RS05945	COG0123	including yeast histone deacetylase and acetoin utilization protein
E5139_RS06020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5139_RS06055	COG0133	tryptophan synthase activity
E5139_RS06065	COG2130	NADP-dependent
E5139_RS06095	COG0602	queuosine metabolic process
E5139_RS06105	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E5139_RS06120	COG0756	dUTP diphosphatase activity
E5139_RS06125	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5139_RS06135	COG1214	PFAM Peptidase M22, glycoprotease
E5139_RS06135	COG0456	acetyltransferase
E5139_RS06160	COG0494	nUDIX hydrolase
E5139_RS06165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5139_RS06170	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E5139_RS06220	COG0842	Transport permease protein
E5139_RS06225	COG1131	(ABC) transporter
E5139_RS06265	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E5139_RS06270	COG5000	phosphorelay sensor kinase activity
E5139_RS06290	COG0714	Associated with various cellular activities
E5139_RS06325	COG3119	arylsulfatase activity
E5139_RS06335	COG0673	inositol 2-dehydrogenase activity
E5139_RS06360	COG0656	L-ascorbic acid biosynthetic process
E5139_RS06375	COG1278	Cold shock
E5139_RS06400	COG0435	Glutathione S-transferase
E5139_RS06420	COG0189	ligase activity
E5139_RS06470	COG0167	dihydroorotate dehydrogenase activity
E5139_RS06520	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5139_RS06535	COG0022	dehydrogenase e1 component
E5139_RS06565	COG1902	pentaerythritol trinitrate reductase activity
E5139_RS06570	COG0495	leucyl-tRNA aminoacylation
E5139_RS06590	COG0534	Mate efflux family protein
E5139_RS06595	COG0579	oxidoreductase
E5139_RS06620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E5139_RS06660	COG0459	protein refolding
E5139_RS06700	COG0534	Mate efflux family protein
E5139_RS06705	COG1522	sequence-specific DNA binding
E5139_RS06730	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
E5139_RS06745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E5139_RS06775	COG0116	Belongs to the methyltransferase superfamily
E5139_RS06820	COG0745	RESPONSE REGULATOR receiver
E5139_RS06830	COG2311	Membrane
E5139_RS06835	COG0321	lipoyl(octanoyl) transferase activity
E5139_RS06835	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E5139_RS06840	COG0464	growth
E5139_RS06860	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5139_RS06860	COG4651	solute:proton antiporter activity
E5139_RS06865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5139_RS06870	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E5139_RS06885	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E5139_RS06895	COG0531	amino acid
E5139_RS06925	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E5139_RS06935	COG0402	S-adenosylhomocysteine deaminase activity
E5139_RS06945	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E5139_RS06955	COG0527	aspartate kinase activity
E5139_RS06965	COG1253	flavin adenine dinucleotide binding
E5139_RS07015	COG0137	argininosuccinate synthase activity
E5139_RS07020	COG0165	Argininosuccinate lyase
E5139_RS07030	COG0189	ligase activity
E5139_RS07035	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E5139_RS07040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5139_RS07045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5139_RS07050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5139_RS07055	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E5139_RS07075	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E5139_RS07125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5139_RS07135	COG0423	glycine-tRNA ligase activity
E5139_RS07145	COG0475	glutathione-regulated potassium exporter activity
E5139_RS07150	COG0490	domain, Protein
E5139_RS07155	COG0556	nucleotide-excision repair
E5139_RS07170	COG0039	L-malate dehydrogenase activity
E5139_RS07220	COG1160	GTP binding
E5139_RS07245	COG2873	o-acetylhomoserine
E5139_RS07255	COG0560	Phosphoserine phosphatase
E5139_RS07330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5139_RS07335	COG0251	oxidation-reduction process
E5139_RS07350	COG0372	Belongs to the citrate synthase family
E5139_RS07365	COG3608	succinylglutamate desuccinylase aspartoacylase
E5139_RS07370	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E5139_RS07405	COG2252	PERMEase
E5139_RS07410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E5139_RS07415	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E5139_RS07425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5139_RS07435	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E5139_RS07460	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E5139_RS07475	COG0131	Imidazoleglycerol-phosphate dehydratase
E5139_RS07500	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
E5139_RS07520	COG4555	ABC transporter
E5139_RS07535	COG1739	Uncharacterized protein family UPF0029
E5139_RS07540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E5139_RS07560	COG2358	TRAP transporter, solute receptor (TAXI family
E5139_RS07580	COG1253	flavin adenine dinucleotide binding
E5139_RS07595	COG0009	L-threonylcarbamoyladenylate synthase
E5139_RS07625	COG4106	trans-aconitate 2-methyltransferase activity
E5139_RS07650	COG0495	leucyl-tRNA aminoacylation
E5139_RS07705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5139_RS07720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E5139_RS07730	COG0521	Mo-molybdopterin cofactor biosynthetic process
E5139_RS07735	COG0315	cyclic pyranopterin monophosphate synthase activity
E5139_RS07745	COG0314	molybdopterin synthase activity
E5139_RS07755	COG1522	sequence-specific DNA binding
E5139_RS07765	COG0004	ammonium transporteR
E5139_RS07775	COG0113	porphobilinogen synthase activity
E5139_RS07800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5139_RS07805	COG3002	Belongs to the UPF0753 family
E5139_RS07810	COG1058	Belongs to the CinA family
E5139_RS07810	COG1546	Belongs to the CinA family
E5139_RS07815	COG2181	nitrate reductase activity
E5139_RS07815	COG0247	lactate metabolic process
E5139_RS07840	COG0251	oxidation-reduction process
E5139_RS07845	COG1028	Short-chain dehydrogenase reductase Sdr
E5139_RS07855	COG0395	ABC-type sugar transport system, permease component
E5139_RS07875	COG3842	ATPase activity
E5139_RS07985	COG0569	domain protein
E5139_RS08005	COG0459	protein refolding
E5139_RS08060	COG0077	Prephenate dehydratase
E5139_RS08080	COG2030	dehydratase
E5139_RS08105	COG1028	Short-chain dehydrogenase reductase Sdr
E5139_RS08120	COG0110	maltose O-acetyltransferase activity
E5139_RS08130	COG0805	protein transport
E5139_RS08135	COG0805	protein transport
E5139_RS08140	COG5002	protein histidine kinase activity
E5139_RS08145	COG1606	tRNA processing
E5139_RS08195	COG1121	(ABC) transporter
E5139_RS08200	COG0803	Belongs to the bacterial solute-binding protein 9 family
E5139_RS08235	COG1744	ABC transporter substrate-binding protein PnrA-like
E5139_RS08240	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E5139_RS08260	COG1028	Short-chain dehydrogenase reductase Sdr
E5139_RS08270	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E5139_RS08270	COG0662	Cupin 2, conserved barrel domain protein
E5139_RS08330	COG0471	metal ion transport
E5139_RS08330	COG3273	potassium ion transport
E5139_RS08395	COG0455	bacterial-type flagellum organization
E5139_RS08445	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E5139_RS08475	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
E5139_RS08485	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E5139_RS08495	COG0667	Aldo Keto reductase
E5139_RS08500	COG1234	tRNA 3'-trailer cleavage
E5139_RS08505	COG0702	epimerase
E5139_RS08520	COG0322	excinuclease ABC activity
E5139_RS08525	COG0531	amino acid
E5139_RS08570	COG1131	(ABC) transporter
E5139_RS08580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5139_RS08600	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E5139_RS08610	COG0714	Associated with various cellular activities
E5139_RS08640	COG2873	o-acetylhomoserine
E5139_RS08645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5139_RS08680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5139_RS08680	COG1648	precorrin-2 dehydrogenase activity
E5139_RS08685	COG0181	hydroxymethylbilane synthase activity
E5139_RS08695	COG0506	proline dehydrogenase activity
E5139_RS08720	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5139_RS08720	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5139_RS08760	COG1960	acyl-CoA dehydrogenase activity
E5139_RS08765	COG0519	Catalyzes the synthesis of GMP from XMP
E5139_RS08780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E5139_RS08830	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E5139_RS08840	COG1691	(AIR) carboxylase
E5139_RS08845	COG2827	Endonuclease containing a URI domain
E5139_RS08850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5139_RS08875	COG2897	thiosulfate sulfurtransferase activity
E5139_RS08890	COG0431	NADPH-dependent FMN reductase
E5139_RS08900	COG0402	S-adenosylhomocysteine deaminase activity
E5139_RS08915	COG0556	nucleotide-excision repair
E5139_RS08955	COG1024	Enoyl-CoA hydratase
E5139_RS08980	COG0667	Aldo Keto reductase
E5139_RS08990	COG2239	Acts as a magnesium transporter
E5139_RS08995	COG0656	L-ascorbic acid biosynthetic process
E5139_RS09000	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E5139_RS09025	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E5139_RS09040	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E5139_RS09065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5139_RS09110	COG0601	transmembrane transport
E5139_RS09120	COG0444	Belongs to the ABC transporter superfamily
E5139_RS09140	COG0501	Belongs to the peptidase M48B family
E5139_RS09160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5139_RS09210	COG3119	arylsulfatase activity
E5139_RS09240	COG1091	dTDP-4-dehydrorhamnose reductase activity
E5139_RS09275	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5139_RS09305	COG0552	protein localization to endoplasmic reticulum
E5139_RS09350	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E5139_RS09370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E5139_RS09410	COG3253	May function as heme-dependent peroxidase
E5139_RS09420	COG0822	iron-sulfur transferase activity
E5139_RS09520	COG2226	methyltransferase
E5139_RS09530	COG1269	ATP hydrolysis coupled proton transport
E5139_RS09555	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E5139_RS09580	COG1394	ATPase activity, coupled to movement of substances
E5139_RS09595	COG2894	cell division
E5139_RS09600	COG0018	arginyl-trna synthetase
E5139_RS09615	COG0528	UMP kinase activity
E5139_RS09655	COG0124	histidyl-tRNA synthetase
E5139_RS09675	COG1164	Oligoendopeptidase f
E5139_RS09680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5139_RS09705	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E5139_RS09735	COG0166	Belongs to the GPI family
E5139_RS09750	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5139_RS09755	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5139_RS09760	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5139_RS09775	COG1278	Cold shock
E5139_RS09785	COG1012	belongs to the aldehyde dehydrogenase family
E5139_RS09795	COG0572	uridine kinase
E5139_RS09815	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E5139_RS09840	COG2135	peptidase activity
E5139_RS09880	COG0129	dihydroxy-acid dehydratase activity
E5139_RS09910	COG1914	H( )-stimulated, divalent metal cation uptake system
E5139_RS09945	COG1233	COG1233 Phytoene dehydrogenase and related
E5139_RS09970	COG0714	Associated with various cellular activities
E5139_RS10040	COG4948	Mandelate Racemase Muconate Lactonizing
E5139_RS10090	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E5139_RS10110	COG0504	CTP synthase activity
E5139_RS10115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5139_RS10115	COG0519	Catalyzes the synthesis of GMP from XMP
E5139_RS10145	COG0521	Mo-molybdopterin cofactor biosynthetic process
E5139_RS10150	COG0604	alcohol dehydrogenase
E5139_RS10160	COG3842	ATPase activity
E5139_RS10195	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E5139_RS10215	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E5139_RS10230	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E5139_RS10240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E5139_RS10245	COG0788	formyltetrahydrofolate deformylase activity
E5139_RS10270	COG0047	phosphoribosylformylglycinamidine synthase activity
E5139_RS10290	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E5139_RS10295	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E5139_RS10330	COG2202	Pas domain
E5139_RS10330	COG1366	Belongs to the anti-sigma-factor antagonist family
E5139_RS10345	COG1053	succinate dehydrogenase
E5139_RS10385	COG0346	lactoylglutathione lyase activity
E5139_RS10410	COG3119	arylsulfatase activity
E5139_RS10415	COG1132	(ABC) transporter
E5139_RS10425	COG2089	acid synthase
E5139_RS10430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E5139_RS10440	COG2226	methyltransferase
E5139_RS10450	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E5139_RS10465	COG1028	Short-chain dehydrogenase reductase Sdr
E5139_RS10470	COG1083	cytidylyl-transferase
E5139_RS10485	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5139_RS10490	COG1086	Polysaccharide biosynthesis protein
E5139_RS10560	COG0667	Aldo Keto reductase
E5139_RS10575	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E5139_RS10580	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E5139_RS10585	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
E5139_RS10600	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E5139_RS10605	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E5139_RS10650	COG0538	isocitrate dehydrogenase activity
E5139_RS10680	COG5002	protein histidine kinase activity
E5139_RS10710	COG1136	(ABC) transporter
E5139_RS10715	COG0577	efflux transmembrane transporter activity
E5139_RS10715	COG1136	(ABC) transporter
E5139_RS10730	COG1028	Short-chain dehydrogenase reductase Sdr
E5139_RS10735	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E5139_RS10755	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5139_RS10795	COG0501	Belongs to the peptidase M48B family
E5139_RS10825	COG1082	Xylose isomerase domain protein TIM barrel
E5139_RS10830	COG0358	DNA primase activity
E5139_RS10845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5139_RS10850	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5139_RS10855	COG1278	Cold shock
E5139_RS10860	COG1278	Cold shock
E5139_RS10885	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E5139_RS10910	COG0243	molybdopterin cofactor binding
E5139_RS10915	COG0437	4 iron, 4 sulfur cluster binding
E5139_RS10935	COG0489	protein tyrosine kinase activity
E5139_RS10950	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E5139_RS11030	COG0745	RESPONSE REGULATOR receiver
E5139_RS11045	COG0596	Alpha beta hydrolase
E5139_RS11060	COG0475	glutathione-regulated potassium exporter activity
E5139_RS11060	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5139_RS11070	COG2814	Major facilitator Superfamily
E5139_RS11080	COG4608	Belongs to the ABC transporter superfamily
E5139_RS11085	COG0444	Belongs to the ABC transporter superfamily
E5139_RS11090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5139_RS11095	COG0601	transmembrane transport
E5139_RS11130	COG0010	Belongs to the arginase family
E5139_RS11145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5139_RS11155	COG0303	'Molybdopterin
E5139_RS11170	COG2154	pterin-4-alpha-carbinolamine dehydratase
E5139_RS11175	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E5139_RS11180	COG1648	precorrin-2 dehydrogenase activity
E5139_RS11180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5139_RS11215	COG1902	pentaerythritol trinitrate reductase activity
E5139_RS11220	COG0346	lactoylglutathione lyase activity
E5139_RS11235	COG3408	Glycogen debranching enzyme
E5139_RS11235	COG3119	arylsulfatase activity
E5139_RS11240	COG1968	undecaprenyl-diphosphatase activity
E5139_RS11260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5139_RS11265	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E5139_RS11310	COG0840	transmembrane signaling receptor activity
E5139_RS11315	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
E5139_RS11325	COG0083	homoserine kinase activity
E5139_RS11345	COG3011	Protein conserved in bacteria
E5139_RS11350	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E5139_RS11365	COG0252	asparaginase activity
E5139_RS11385	COG4946	Tricorn protease homolog
E5139_RS11385	COG1506	peptidase
E5139_RS11385	COG0823	Involved in the tonB-independent uptake of proteins
E5139_RS11405	COG0589	response to stress
E5139_RS11415	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
E5139_RS11420	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E5139_RS11430	COG0745	RESPONSE REGULATOR receiver
E5139_RS11460	COG4191	Histidine kinase
E5139_RS11485	COG1111	helicase
E5139_RS11485	COG1205	dead DEAH box helicase
E5139_RS11505	COG0535	radical SAM domain protein
E5139_RS11525	COG0110	maltose O-acetyltransferase activity
E5139_RS11555	COG0765	amino acid transport
E5139_RS11565	COG0765	amino acid transport
E5139_RS11585	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E5139_RS11775	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E5139_RS11780	COG1102	Psort location Cytoplasmic, score
E5139_RS11860	COG0745	RESPONSE REGULATOR receiver
E5139_RS11880	COG0280	phosphate acetyltransferase
E5139_RS11880	COG0281	malic enzyme
E5139_RS11890	COG1612	heme a metabolic process
E5139_RS11920	COG5002	protein histidine kinase activity
E5139_RS11945	COG0512	Glutamine amidotransferase of anthranilate synthase
E5139_RS11950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E5139_RS11955	COG0135	phosphoribosylanthranilate isomerase activity
E5139_RS11960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5139_RS12005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5139_RS12015	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
E5139_RS12060	COG0581	inorganic phosphate transmembrane transporter activity
E5139_RS12065	COG0573	inorganic phosphate transmembrane transporter activity
E5139_RS12070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E5139_RS12080	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E5139_RS12085	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5139_RS12110	COG0284	orotidine-5'-phosphate decarboxylase activity
E5139_RS12140	COG0534	Mate efflux family protein
E5139_RS12145	COG0561	phosphatase activity
E5139_RS12150	COG0798	PFAM Bile acid sodium symporter
E5139_RS12160	COG0640	Transcriptional regulator
E5139_RS12165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5139_RS12185	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
E5139_RS12205	COG3842	ATPase activity
E5139_RS12210	COG0395	ABC-type sugar transport system, permease component
E5139_RS12215	COG1175	transmembrane transport
E5139_RS12245	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E5139_RS12265	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E5139_RS12275	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E5139_RS12290	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E5139_RS12295	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E5139_RS12310	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E5139_RS12320	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E5139_RS12325	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E5139_RS12345	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E5139_RS12390	COG1648	precorrin-2 dehydrogenase activity
E5139_RS12390	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5139_RS12435	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
E5139_RS12520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5139_RS12530	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E5139_RS12535	COG1271	oxidase subunit
E5139_RS12570	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E5139_RS12575	COG0509	glycine decarboxylation via glycine cleavage system
E5139_RS12585	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5139_RS12590	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5139_RS12595	COG0864	Transcriptional regulator
E5139_RS12600	COG3275	phosphorelay sensor kinase activity
E5139_RS12605	COG0745	RESPONSE REGULATOR receiver
E5139_RS12620	COG2096	Adenosyltransferase
E5139_RS12630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5139_RS12635	COG1185	polyribonucleotide nucleotidyltransferase activity
E5139_RS12645	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E5139_RS12645	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E5139_RS12660	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E5139_RS12670	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E5139_RS12680	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E5139_RS12685	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5139_RS12690	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5139_RS12695	COG0649	NAD binding
E5139_RS12705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5139_RS12730	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5139_RS12735	COG1007	ATP synthesis coupled electron transport
E5139_RS12770	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E5139_RS12775	COG3842	ATPase activity
E5139_RS12790	COG1621	beta-fructofuranosidase activity
E5139_RS12820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E5139_RS12865	COG2264	protein methyltransferase activity
E5139_RS12920	COG0107	imidazoleglycerol-phosphate synthase activity
E5139_RS12930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5139_RS12950	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5139_RS13020	COG0535	radical SAM domain protein
E5139_RS13030	COG0587	DNA-directed DNA polymerase activity
E5139_RS13065	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5139_RS13070	COG0154	amidase activity
E5139_RS13075	COG0501	Belongs to the peptidase M48B family
E5139_RS13085	COG0438	transferase activity, transferring glycosyl groups
E5139_RS13105	COG0668	transmembrane transport
E5139_RS13130	COG1832	CoA-binding protein
E5139_RS13145	COG3177	Filamentation induced by cAMP protein fic
E5139_RS13155	COG0492	ferredoxin-NADP+ reductase activity
E5139_RS13180	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E5139_RS13185	COG0589	response to stress
E5139_RS13255	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E5139_RS13290	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5139_RS13305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5139_RS13320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5139_RS13375	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E5139_RS13380	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E5139_RS13390	COG1733	regulation of RNA biosynthetic process
E5139_RS13400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5139_RS13405	COG2239	Acts as a magnesium transporter
E5139_RS13410	COG1940	carbohydrate kinase activity
E5139_RS13460	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5139_RS13465	COG1960	acyl-CoA dehydrogenase activity
E5139_RS13475	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E5139_RS13490	COG1045	serine acetyltransferase
E5139_RS13495	COG0189	ligase activity
E5139_RS13515	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E5139_RS13525	COG0402	S-adenosylhomocysteine deaminase activity
E5139_RS13545	COG1960	acyl-CoA dehydrogenase activity
E5139_RS13560	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E5139_RS13565	COG2267	carboxylic ester hydrolase activity
E5139_RS13595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E5139_RS13605	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E5139_RS13620	COG1363	Peptidase, m42
E5139_RS13680	COG0714	Associated with various cellular activities
E5139_RS13705	COG1201	RNA secondary structure unwinding
E5139_RS13710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5139_RS13755	COG1335	isochorismatase
E5139_RS13870	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
E5139_RS13875	COG0436	Aminotransferase
E5139_RS13880	COG1522	sequence-specific DNA binding
E5139_RS13895	COG0434	BtpA family
E5139_RS13930	COG0674	pyruvate-flavodoxin oxidoreductase activity
E5139_RS13930	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E5139_RS13935	COG1013	pyruvate-flavodoxin oxidoreductase activity
E5139_RS13940	COG1522	sequence-specific DNA binding
E5139_RS13955	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5139_RS13955	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5139_RS13965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5139_RS13975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5139_RS14030	COG0215	cysteine-tRNA ligase activity
E5139_RS14035	COG0598	Magnesium transport protein CorA
E5139_RS14055	COG0081	regulation of translation
E5139_RS14060	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E5139_RS14080	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E5139_RS14100	COG1185	polyribonucleotide nucleotidyltransferase activity
E5139_RS14120	COG0431	NADPH-dependent FMN reductase
E5139_RS14160	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
E5139_RS14165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E5139_RS14195	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E5139_RS14205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5139_RS14235	COG0483	inositol monophosphate 1-phosphatase activity
E5139_RS14260	COG2988	succinylglutamate desuccinylase activity
E5139_RS14275	COG5002	protein histidine kinase activity
E5139_RS14285	COG2766	serine protein kinase
E5139_RS14300	COG2719	SpoVR family
E5139_RS14335	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E5139_RS14360	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E5139_RS14375	COG0318	PFAM AMP-dependent synthetase and ligase
E5139_RS14385	COG1575	Belongs to the MenA family. Type 1 subfamily
E5139_RS14395	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E5139_RS14405	COG4948	Mandelate Racemase Muconate Lactonizing
E5139_RS14415	COG1082	Xylose isomerase domain protein TIM barrel
E5139_RS14425	COG0673	inositol 2-dehydrogenase activity
E5139_RS14435	COG0366	Alpha amylase catalytic
E5139_RS14470	COG3842	ATPase activity
E5139_RS14495	COG0463	Glycosyl transferase, family 2
E5139_RS14510	COG3842	ATPase activity
E5139_RS14530	COG1028	Short-chain dehydrogenase reductase Sdr
E5139_RS14535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5139_RS14570	COG0783	Belongs to the Dps family
E5139_RS14585	COG0857	belongs to the CobB CobQ family
E5139_RS14600	COG1748	Saccharopine dehydrogenase
E5139_RS14605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E5139_RS14610	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E5139_RS14625	COG2894	cell division
E5139_RS14630	COG0540	Belongs to the ATCase OTCase family
E5139_RS14635	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E5139_RS14645	COG1047	Peptidyl-prolyl cis-trans
E5139_RS14655	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
E5139_RS14675	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5139_RS14685	COG2860	membrane
E5139_RS14695	COG1331	Highly conserved protein containing a thioredoxin domain
E5139_RS14705	COG0151	Belongs to the GarS family
E5139_RS14710	COG0110	maltose O-acetyltransferase activity
E5139_RS14770	COG2133	pyrroloquinoline quinone binding
E5139_RS14790	COG1546	Belongs to the CinA family
E5139_RS14790	COG1058	Belongs to the CinA family
E5139_RS14830	COG2133	pyrroloquinoline quinone binding
E5139_RS14835	COG1012	belongs to the aldehyde dehydrogenase family
E5139_RS14840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5139_RS14860	COG1605	Chorismate mutase
E5139_RS14860	COG0287	Prephenate dehydrogenase
E5139_RS14885	COG0697	spore germination
E5139_RS14890	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E5139_RS14905	COG0517	IMP dehydrogenase activity
E5139_RS14905	COG0516	GMP reductase activity
E5139_RS14960	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5139_RS14975	COG0745	RESPONSE REGULATOR receiver
E5139_RS14980	COG1426	Protein conserved in bacteria
E5139_RS14985	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5139_RS14985	COG1213	nucleotidyl transferase
E5139_RS14995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5139_RS15030	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5139_RS15035	COG1253	flavin adenine dinucleotide binding
E5139_RS15115	COG2890	protein-(glutamine-N5) methyltransferase activity
E5139_RS15140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5139_RS15145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E5139_RS15145	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E5139_RS15150	COG1254	Belongs to the acylphosphatase family
E5139_RS15190	COG0492	ferredoxin-NADP+ reductase activity
E5139_RS15235	COG0840	transmembrane signaling receptor activity
E5139_RS15235	COG3290	protein histidine kinase activity
E5139_RS15240	COG1201	RNA secondary structure unwinding
E5139_RS15265	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E5139_RS15275	COG1193	negative regulation of DNA recombination
E5139_RS15330	COG1120	ATPase activity
E5139_RS15335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5139_RS15350	COG1295	ribonuclease BN
E5139_RS15355	COG1022	Amp-dependent synthetase and ligase
E5139_RS15370	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E5139_RS15445	COG0489	protein tyrosine kinase activity
E5139_RS15470	COG1140	nitrate reductase beta subunit
E5139_RS15475	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E5139_RS15485	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E5139_RS15500	COG0668	transmembrane transport
E5139_RS15545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5139_RS15555	COG2264	protein methyltransferase activity
E5139_RS15625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E5139_RS15630	COG0303	'Molybdopterin
E5139_RS15635	COG0303	'Molybdopterin
E5139_RS15645	COG0640	Transcriptional regulator
E5139_RS15685	COG1940	carbohydrate kinase activity
E5139_RS15695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5139_RS15700	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E5139_RS15705	COG1653	transport
E5139_RS15710	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E5139_RS15720	COG0247	lactate metabolic process
E5139_RS15735	COG1131	(ABC) transporter
E5139_RS15740	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E5139_RS15745	COG2267	carboxylic ester hydrolase activity
E5139_RS15780	COG0559	Belongs to the binding-protein-dependent transport system permease family
E5139_RS15790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5139_RS15800	COG0673	inositol 2-dehydrogenase activity
E5139_RS15805	COG0484	heat shock protein binding
E5139_RS15810	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E5139_RS15835	COG1024	Enoyl-CoA hydratase
E5139_RS15835	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5139_RS15840	COG0415	Belongs to the DNA photolyase family
E5139_RS15845	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E5139_RS15860	COG0745	RESPONSE REGULATOR receiver
E5139_RS15895	COG3842	ATPase activity
E5139_RS15905	COG0589	response to stress
E5139_RS15915	COG0589	response to stress
E5139_RS15940	COG0656	L-ascorbic acid biosynthetic process
E5139_RS15960	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5139_RS15970	COG1796	DNA polymerase
E5139_RS15970	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E5139_RS15995	COG0395	ABC-type sugar transport system, permease component
E5139_RS16000	COG3842	ATPase activity
E5139_RS16005	COG3250	beta-galactosidase activity
E5139_RS16035	COG0719	Fe-S assembly protein
E5139_RS16075	COG0443	Heat shock 70 kDa protein
E5139_RS16120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5139_RS16135	COG0714	Associated with various cellular activities
E5139_RS16140	COG2304	oxidoreductase activity
E5139_RS16200	COG0243	molybdopterin cofactor binding
E5139_RS16275	COG0631	protein serine/threonine phosphatase activity
E5139_RS16300	COG2815	serine threonine protein kinase
E5139_RS16300	COG0515	serine threonine protein kinase
E5139_RS16325	COG2815	serine threonine protein kinase
E5139_RS16325	COG0515	serine threonine protein kinase
E5139_RS16395	COG0515	serine threonine protein kinase
E5139_RS16395	COG2815	serine threonine protein kinase
E5139_RS16410	COG1074	ATP-dependent DNA helicase activity
E5139_RS16420	COG4191	Histidine kinase
E5139_RS16435	COG1121	(ABC) transporter
E5139_RS16440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5139_RS16490	COG2226	methyltransferase
E5139_RS16510	COG0076	glutamate decarboxylase activity
E5139_RS16545	COG0534	Mate efflux family protein
E5139_RS16575	COG0640	Transcriptional regulator
E5139_RS16600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5139_RS16605	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5139_RS16610	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5139_RS16695	COG0415	Belongs to the DNA photolyase family
E5139_RS16705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5139_RS16720	COG2217	Heavy metal translocating P-type atpase
E5139_RS16745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5139_RS16750	COG0525	valine-tRNA ligase activity
E5139_RS16765	COG2210	Belongs to the sulfur carrier protein TusA family
E5139_RS16770	COG0425	Belongs to the sulfur carrier protein TusA family
E5139_RS16775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5139_RS16775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5139_RS16790	COG0306	phosphate transporter