locus-tag	class	description
LOKO_RS00015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LOKO_RS00035	COG0667	Aldo Keto reductase
LOKO_RS00055	COG0683	leucine binding
LOKO_RS00080	COG0733	neurotransmitter:sodium symporter activity
LOKO_RS00090	COG1737	Transcriptional regulator
LOKO_RS00120	COG2204	response regulator
LOKO_RS00135	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LOKO_RS00145	COG0023	Translation Initiation Factor
LOKO_RS00180	COG0126	phosphoglycerate kinase activity
LOKO_RS00185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LOKO_RS00190	COG1346	cytolysis
LOKO_RS00200	COG0071	Belongs to the small heat shock protein (HSP20) family
LOKO_RS00205	COG0071	Belongs to the small heat shock protein (HSP20) family
LOKO_RS00210	COG1830	Aldolase
LOKO_RS00215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LOKO_RS00220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LOKO_RS00250	COG2032	superoxide dismutase activity
LOKO_RS00270	COG1283	sodium-dependent phosphate transmembrane transporter activity
LOKO_RS00280	COG0339	signal peptide processing
LOKO_RS00285	COG0733	neurotransmitter:sodium symporter activity
LOKO_RS00290	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LOKO_RS00315	COG0247	lactate metabolic process
LOKO_RS00320	COG1139	Iron-sulfur cluster binding protein
LOKO_RS00355	COG2154	pterin-4-alpha-carbinolamine dehydratase
LOKO_RS00370	COG0514	ATP-dependent DNA helicase (RecQ)
LOKO_RS00395	COG0011	TIGRFAM Protein of
LOKO_RS00405	COG3290	protein histidine kinase activity
LOKO_RS00420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LOKO_RS00420	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LOKO_RS00445	COG0028	Belongs to the TPP enzyme family
LOKO_RS00450	COG0440	acetolactate synthase activity
LOKO_RS00455	COG0583	DNA-binding transcription factor activity
LOKO_RS00460	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LOKO_RS00465	COG1183	phosphatidylcholine synthase activity
LOKO_RS00495	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LOKO_RS00530	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LOKO_RS00535	COG0081	regulation of translation
LOKO_RS00540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LOKO_RS00545	COG0222	ribosome binding
LOKO_RS00550	COG0085	RNA polymerase activity
LOKO_RS00555	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LOKO_RS00560	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LOKO_RS00565	COG0049	tRNA binding
LOKO_RS00570	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LOKO_RS00575	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LOKO_RS00580	COG0051	transcription antitermination factor activity, RNA binding
LOKO_RS00585	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LOKO_RS00590	COG0088	Forms part of the polypeptide exit tunnel
LOKO_RS00595	COG0089	rRNA binding
LOKO_RS00600	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LOKO_RS00605	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LOKO_RS00610	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LOKO_RS00615	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LOKO_RS00620	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LOKO_RS00625	COG0255	Belongs to the universal ribosomal protein uL29 family
LOKO_RS00630	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LOKO_RS00635	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LOKO_RS00640	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LOKO_RS00645	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LOKO_RS00650	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LOKO_RS00655	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LOKO_RS00660	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LOKO_RS00665	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LOKO_RS00670	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LOKO_RS00675	COG1841	ribosomal large subunit assembly
LOKO_RS00680	COG0200	Binds to the 23S rRNA
LOKO_RS00690	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LOKO_RS00695	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LOKO_RS00700	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LOKO_RS00705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LOKO_RS00710	COG0202	RNA polymerase activity
LOKO_RS00715	COG0203	ribosomal protein L17
LOKO_RS00725	COG2814	Major facilitator Superfamily
LOKO_RS00750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LOKO_RS00760	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LOKO_RS00775	COG0300	oxidoreductase activity
LOKO_RS00785	COG0415	Belongs to the DNA photolyase family
LOKO_RS00790	COG0789	Transcriptional regulator
LOKO_RS00795	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
LOKO_RS00800	COG1090	epimerase
LOKO_RS00805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LOKO_RS00810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LOKO_RS00820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LOKO_RS00825	COG0471	metal ion transport
LOKO_RS00830	COG5002	protein histidine kinase activity
LOKO_RS00830	COG5001	Diguanylate cyclase
LOKO_RS00830	COG3447	MASE1 domain protein
LOKO_RS00840	COG0142	geranyltranstransferase activity
LOKO_RS00845	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LOKO_RS00850	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LOKO_RS00855	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LOKO_RS00860	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LOKO_RS00865	COG0268	Binds directly to 16S ribosomal RNA
LOKO_RS00875	COG0196	riboflavin kinase activity
LOKO_RS00880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LOKO_RS00890	COG1047	Peptidyl-prolyl cis-trans
LOKO_RS00895	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LOKO_RS00915	COG1309	transcriptional regulator
LOKO_RS00920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LOKO_RS00930	COG0625	glutathione transferase activity
LOKO_RS00940	COG2203	Gaf domain
LOKO_RS00940	COG3706	GGDEF domain
LOKO_RS00940	COG5001	Diguanylate cyclase
LOKO_RS00940	COG4251	negative regulation of phosphorylation
LOKO_RS00950	COG1944	ATP diphosphatase activity
LOKO_RS00965	COG0300	oxidoreductase activity
LOKO_RS00970	COG1994	Peptidase M50
LOKO_RS00970	COG0517	IMP dehydrogenase activity
LOKO_RS01005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LOKO_RS01010	COG1131	(ABC) transporter
LOKO_RS01015	COG0842	Transport permease protein
LOKO_RS01020	COG3706	GGDEF domain
LOKO_RS01030	COG0505	Belongs to the CarA family
LOKO_RS01035	COG1132	(ABC) transporter
LOKO_RS01045	COG0840	transmembrane signaling receptor activity
LOKO_RS01050	COG2433	Pfam Transposase IS66
LOKO_RS01055	COG0569	domain protein
LOKO_RS01060	COG3360	Dodecin
LOKO_RS01070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LOKO_RS01075	COG0242	peptide deformylase activity
LOKO_RS01085	COG0758	DNA mediated transformation
LOKO_RS01090	COG0009	L-threonylcarbamoyladenylate synthase
LOKO_RS01095	COG0408	coproporphyrinogen oxidase activity
LOKO_RS01100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LOKO_RS01110	COG0601	transmembrane transport
LOKO_RS01115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LOKO_RS01135	COG0501	Belongs to the peptidase M48B family
LOKO_RS01150	COG1160	GTP binding
LOKO_RS01160	COG2976	Protein conserved in bacteria
LOKO_RS01165	COG0124	histidyl-tRNA synthetase
LOKO_RS01170	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LOKO_RS01185	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LOKO_RS01190	COG0105	UTP biosynthetic process
LOKO_RS01200	COG1104	cysteine desulfurase activity
LOKO_RS01205	COG1959	2 iron, 2 sulfur cluster binding
LOKO_RS01235	COG1862	Preprotein translocase
LOKO_RS01240	COG0343	queuine tRNA-ribosyltransferase activity
LOKO_RS01245	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LOKO_RS01320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LOKO_RS01330	COG2203	Gaf domain
LOKO_RS01330	COG3706	GGDEF domain
LOKO_RS01330	COG4251	negative regulation of phosphorylation
LOKO_RS01330	COG5001	Diguanylate cyclase
LOKO_RS01335	COG1960	acyl-CoA dehydrogenase activity
LOKO_RS01345	COG0714	Associated with various cellular activities
LOKO_RS01360	COG0386	Belongs to the glutathione peroxidase family
LOKO_RS01370	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LOKO_RS01385	COG2226	methyltransferase
LOKO_RS01405	COG1012	belongs to the aldehyde dehydrogenase family
LOKO_RS01410	COG3724	N-succinylarginine dihydrolase activity
LOKO_RS01445	COG0156	8-amino-7-oxononanoate synthase activity
LOKO_RS01450	COG1063	alcohol dehydrogenase
LOKO_RS01475	COG5001	Diguanylate cyclase
LOKO_RS01475	COG5002	protein histidine kinase activity
LOKO_RS01520	COG2329	Antibiotic biosynthesis monooxygenase
LOKO_RS01525	COG0793	Belongs to the peptidase S41A family
LOKO_RS01525	COG4946	Tricorn protease homolog
LOKO_RS01530	COG1612	heme a metabolic process
LOKO_RS01540	COG1597	lipid kinase activity
LOKO_RS01545	COG1028	Short-chain dehydrogenase reductase Sdr
LOKO_RS01545	COG0604	alcohol dehydrogenase
LOKO_RS01545	COG3321	synthase
LOKO_RS01550	COG3938	Belongs to the proline racemase family
LOKO_RS01570	COG1363	Peptidase, m42
LOKO_RS01580	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LOKO_RS01580	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LOKO_RS01585	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LOKO_RS01585	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LOKO_RS01590	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LOKO_RS01595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LOKO_RS01600	COG0179	Fumarylacetoacetate (FAA) hydrolase
LOKO_RS01605	COG2186	Transcriptional regulator
LOKO_RS01625	COG2193	ferroxidase activity
LOKO_RS01655	COG0840	transmembrane signaling receptor activity
LOKO_RS01715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LOKO_RS01730	COG3550	peptidyl-serine autophosphorylation
LOKO_RS01740	COG0583	DNA-binding transcription factor activity
LOKO_RS01745	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LOKO_RS01755	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LOKO_RS01760	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
LOKO_RS01775	COG0840	transmembrane signaling receptor activity
LOKO_RS01780	COG3706	GGDEF domain
LOKO_RS01790	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LOKO_RS01820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LOKO_RS01825	COG1074	ATP-dependent DNA helicase activity
LOKO_RS01830	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LOKO_RS01840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LOKO_RS01845	COG0154	amidase activity
LOKO_RS01860	COG0318	PFAM AMP-dependent synthetase and ligase
LOKO_RS01880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LOKO_RS01895	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LOKO_RS01910	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LOKO_RS01920	COG0583	DNA-binding transcription factor activity
LOKO_RS01930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LOKO_RS01945	COG0402	S-adenosylhomocysteine deaminase activity
LOKO_RS01950	COG3181	Tripartite tricarboxylate transporter family receptor
LOKO_RS01985	COG0402	S-adenosylhomocysteine deaminase activity
LOKO_RS01990	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LOKO_RS02000	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LOKO_RS02030	COG0579	oxidoreductase
LOKO_RS02040	COG0210	DNA helicase
LOKO_RS02045	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LOKO_RS02055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LOKO_RS02085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LOKO_RS02095	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LOKO_RS02100	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LOKO_RS02105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LOKO_RS02110	COG0072	phenylalanine-tRNA ligase activity
LOKO_RS02115	COG0776	regulation of translation
LOKO_RS02125	COG0716	FMN binding
LOKO_RS02135	COG1611	Belongs to the LOG family
LOKO_RS02140	COG0583	DNA-binding transcription factor activity
LOKO_RS02150	COG0509	glycine decarboxylation via glycine cleavage system
LOKO_RS02155	COG1115	amino acid carrier protein
LOKO_RS02175	COG0204	Acyl-transferase
LOKO_RS02180	COG0583	DNA-binding transcription factor activity
LOKO_RS02185	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LOKO_RS02200	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LOKO_RS02205	COG0483	inositol monophosphate 1-phosphatase activity
LOKO_RS02215	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LOKO_RS02220	COG2205	protein histidine kinase activity
LOKO_RS02240	COG0446	pyridine nucleotide-disulphide oxidoreductase
LOKO_RS02240	COG1902	pentaerythritol trinitrate reductase activity
LOKO_RS02245	COG2181	nitrate reductase activity
LOKO_RS02245	COG0247	lactate metabolic process
LOKO_RS02250	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LOKO_RS02260	COG1063	alcohol dehydrogenase
LOKO_RS02270	COG3383	formate dehydrogenase (NAD+) activity
LOKO_RS02285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LOKO_RS02290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LOKO_RS02295	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LOKO_RS02300	COG0084	hydrolase, TatD family'
LOKO_RS02315	COG1522	sequence-specific DNA binding
LOKO_RS02320	COG3608	succinylglutamate desuccinylase aspartoacylase
LOKO_RS02325	COG0006	proline dipeptidase activity
LOKO_RS02330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LOKO_RS02340	COG1335	isochorismatase
LOKO_RS02355	COG2431	L-lysine efflux transmembrane transporter activity
LOKO_RS02360	COG1653	transport
LOKO_RS02375	COG0366	Alpha amylase catalytic
LOKO_RS02380	COG3842	ATPase activity
LOKO_RS02385	COG1609	Transcriptional regulator
LOKO_RS02400	COG2205	protein histidine kinase activity
LOKO_RS02405	COG0745	RESPONSE REGULATOR receiver
LOKO_RS02415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LOKO_RS02420	COG0723	plastoquinol--plastocyanin reductase activity
LOKO_RS02425	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LOKO_RS02430	COG2857	Cytochrome c1
LOKO_RS02435	COG0625	glutathione transferase activity
LOKO_RS02440	COG2969	positive regulation of protein catabolic process
LOKO_RS02450	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LOKO_RS02455	COG0792	nuclease activity
LOKO_RS02460	COG3107	peptidoglycan biosynthetic process
LOKO_RS02475	COG0275	rRNA processing
LOKO_RS02480	COG3116	cell division
LOKO_RS02495	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LOKO_RS02500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LOKO_RS02505	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LOKO_RS02510	COG0772	Belongs to the SEDS family
LOKO_RS02515	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LOKO_RS02520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LOKO_RS02525	COG1181	Belongs to the D-alanine--D-alanine ligase family
LOKO_RS02545	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LOKO_RS02550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LOKO_RS02550	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LOKO_RS02560	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LOKO_RS02565	COG1073	alpha beta
LOKO_RS02565	COG2226	methyltransferase
LOKO_RS02570	COG0596	Alpha beta hydrolase
LOKO_RS02575	COG1960	acyl-CoA dehydrogenase activity
LOKO_RS02580	COG1846	Transcriptional regulator
LOKO_RS02590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LOKO_RS02600	COG2967	ApaG domain
LOKO_RS02610	COG0446	pyridine nucleotide-disulphide oxidoreductase
LOKO_RS02610	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LOKO_RS02640	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LOKO_RS02640	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LOKO_RS02645	COG2205	protein histidine kinase activity
LOKO_RS02650	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LOKO_RS02660	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
LOKO_RS02670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LOKO_RS02675	COG5002	protein histidine kinase activity
LOKO_RS02675	COG3447	MASE1 domain protein
LOKO_RS02675	COG5001	Diguanylate cyclase
LOKO_RS02710	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LOKO_RS02715	COG0709	Synthesizes selenophosphate from selenide and ATP
LOKO_RS02720	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
LOKO_RS02735	COG3068	Protein conserved in bacteria
LOKO_RS02745	COG0107	imidazoleglycerol-phosphate synthase activity
LOKO_RS02750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LOKO_RS02755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LOKO_RS02760	COG0131	Imidazoleglycerol-phosphate dehydratase
LOKO_RS02775	COG1194	a g-specific adenine glycosylase
LOKO_RS02780	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LOKO_RS02800	COG5285	phytanoyl-CoA dioxygenase
LOKO_RS02805	COG0179	Fumarylacetoacetate (FAA) hydrolase
LOKO_RS02810	COG1166	arginine decarboxylase activity
LOKO_RS02830	COG3842	ATPase activity
LOKO_RS02835	COG1178	ABC-type Fe3 transport system permease component
LOKO_RS02870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LOKO_RS02875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LOKO_RS02885	COG0747	negative chemotaxis
LOKO_RS02895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LOKO_RS02900	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LOKO_RS02915	COG1609	Transcriptional regulator
LOKO_RS02920	COG3265	gluconokinase activity
LOKO_RS02930	COG1176	ABC-type spermidine putrescine transport system, permease component I
LOKO_RS02935	COG1177	transmembrane transport
LOKO_RS02950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LOKO_RS02975	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LOKO_RS02990	COG1024	Enoyl-CoA hydratase
LOKO_RS02995	COG1061	Type III restriction enzyme res subunit
LOKO_RS03000	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LOKO_RS03005	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LOKO_RS03025	COG5002	protein histidine kinase activity
LOKO_RS03025	COG5001	Diguanylate cyclase
LOKO_RS03025	COG3447	MASE1 domain protein
LOKO_RS03045	COG0628	permease
LOKO_RS03085	COG0562	UDP-galactopyranose mutase
LOKO_RS03090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LOKO_RS03105	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LOKO_RS03115	COG0425	Belongs to the sulfur carrier protein TusA family
LOKO_RS03125	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LOKO_RS03130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LOKO_RS03140	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LOKO_RS03145	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LOKO_RS03150	COG1720	tRNA m6t6A37 methyltransferase activity
LOKO_RS03165	COG3023	N-Acetylmuramoyl-L-alanine amidase
LOKO_RS03180	COG0563	adenylate kinase activity
LOKO_RS03190	COG0742	ribosomal rna small subunit methyltransferase
LOKO_RS03195	COG2937	Belongs to the GPAT DAPAT family
LOKO_RS03200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LOKO_RS03210	COG3091	SprT-like family
LOKO_RS03215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LOKO_RS03220	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LOKO_RS03260	COG2205	protein histidine kinase activity
LOKO_RS03260	COG0784	Response regulator, receiver
LOKO_RS03260	COG2198	Histidine kinase
LOKO_RS03270	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LOKO_RS03290	COG0037	tRNA processing
LOKO_RS03295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LOKO_RS03315	COG2217	Heavy metal translocating P-type atpase
LOKO_RS03325	COG0348	domain, Protein
LOKO_RS03330	COG2010	Cytochrome c
LOKO_RS03345	COG3278	Belongs to the heme-copper respiratory oxidase family
LOKO_RS03380	COG0446	pyridine nucleotide-disulphide oxidoreductase
LOKO_RS03380	COG1902	pentaerythritol trinitrate reductase activity
LOKO_RS03385	COG0745	RESPONSE REGULATOR receiver
LOKO_RS03390	COG2205	protein histidine kinase activity
LOKO_RS03395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LOKO_RS03400	COG2137	regulation of response to DNA damage stimulus
LOKO_RS03405	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LOKO_RS03410	COG1546	Belongs to the CinA family
LOKO_RS03415	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LOKO_RS03420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LOKO_RS03440	COG0494	nUDIX hydrolase
LOKO_RS03450	COG0039	L-malate dehydrogenase activity
LOKO_RS03460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LOKO_RS03475	COG1028	Short-chain dehydrogenase reductase Sdr
LOKO_RS03485	COG1024	Enoyl-CoA hydratase
LOKO_RS03485	COG1250	3-hydroxyacyl-CoA dehydrogenase
LOKO_RS03490	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LOKO_RS03510	COG1538	Outer membrane efflux protein
LOKO_RS03515	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LOKO_RS03520	COG1560	Kdo2-lipid A biosynthetic process
LOKO_RS03530	COG0488	(ABC) transporter
LOKO_RS03540	COG1366	Belongs to the anti-sigma-factor antagonist family
LOKO_RS03540	COG2202	Pas domain
LOKO_RS03565	COG4181	ATPase activity
LOKO_RS03570	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LOKO_RS03580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LOKO_RS03590	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LOKO_RS03625	COG2391	methyltransferase activity
LOKO_RS03635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LOKO_RS03645	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LOKO_RS03650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LOKO_RS03650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LOKO_RS03660	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LOKO_RS03665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LOKO_RS03670	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LOKO_RS03675	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LOKO_RS03685	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LOKO_RS03690	COG1028	Short-chain dehydrogenase reductase Sdr
LOKO_RS03710	COG0129	dihydroxy-acid dehydratase activity
LOKO_RS03715	COG0673	inositol 2-dehydrogenase activity
LOKO_RS03720	COG0494	nUDIX hydrolase
LOKO_RS03725	COG1011	Hydrolase
LOKO_RS03730	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LOKO_RS03735	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LOKO_RS03740	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LOKO_RS03745	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LOKO_RS03750	COG2183	response to ionizing radiation
LOKO_RS03755	COG2918	glutathione biosynthetic process
LOKO_RS03760	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LOKO_RS03785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LOKO_RS03790	COG2813	Specifically methylates the guanine in position
LOKO_RS03815	COG0494	nUDIX hydrolase
LOKO_RS03825	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LOKO_RS03830	COG0175	sulfate reduction
LOKO_RS03835	COG2895	sulfate adenylyltransferase (ATP) activity
LOKO_RS03850	COG2738	Putative neutral zinc metallopeptidase
LOKO_RS03855	COG0500	methyltransferase
LOKO_RS03860	COG4106	trans-aconitate 2-methyltransferase activity
LOKO_RS03865	COG0166	Belongs to the GPI family
LOKO_RS03870	COG3150	esterase
LOKO_RS03875	COG0187	DNA topoisomerase II activity
LOKO_RS03885	COG0560	Phosphoserine phosphatase
LOKO_RS03885	COG3830	Belongs to the UPF0237 family
LOKO_RS03895	COG1028	Short-chain dehydrogenase reductase Sdr
LOKO_RS03910	COG2186	Transcriptional regulator
LOKO_RS03935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LOKO_RS03940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LOKO_RS03945	COG1966	Carbon starvation protein
LOKO_RS03955	COG0003	Pfam Anion-transporting ATPase
LOKO_RS03960	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LOKO_RS03980	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LOKO_RS03985	COG2878	Part of a membrane complex involved in electron transport
LOKO_RS03990	COG3706	GGDEF domain
LOKO_RS03995	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LOKO_RS03995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LOKO_RS04010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LOKO_RS04015	COG3243	poly(R)-hydroxyalkanoic acid synthase
LOKO_RS04035	COG1012	belongs to the aldehyde dehydrogenase family
LOKO_RS04045	COG4221	oxidoreductase activity
LOKO_RS04070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LOKO_RS04080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LOKO_RS04090	COG0688	phosphatidylethanolamine metabolic process
LOKO_RS04100	COG1162	GTPase activity
LOKO_RS04105	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LOKO_RS04115	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LOKO_RS04115	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LOKO_RS04120	COG0802	atpase or kinase
LOKO_RS04125	COG0860	N-Acetylmuramoyl-L-alanine amidase
LOKO_RS04130	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LOKO_RS04135	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LOKO_RS04140	COG1923	regulation of RNA biosynthetic process
LOKO_RS04145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LOKO_RS04150	COG0330	HflC and HflK could
LOKO_RS04155	COG0330	HflC and HflK could
LOKO_RS04160	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LOKO_RS04165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LOKO_RS04175	COG1042	CoA-binding domain protein
LOKO_RS04175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LOKO_RS04175	COG0045	succinate-CoA ligase (ADP-forming) activity
LOKO_RS04180	COG1666	GTP binding
LOKO_RS04185	COG0071	Belongs to the small heat shock protein (HSP20) family
LOKO_RS04190	COG2832	Protein of unknown function (DUF454)
LOKO_RS04195	COG0308	aminopeptidase N
LOKO_RS04220	COG1704	LemA family
LOKO_RS04225	COG0501	Belongs to the peptidase M48B family
LOKO_RS04235	COG1278	Cold shock
LOKO_RS04245	COG0741	lytic transglycosylase activity
LOKO_RS04260	COG0326	Molecular chaperone. Has ATPase activity
LOKO_RS04270	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LOKO_RS04275	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LOKO_RS04285	COG2329	Antibiotic biosynthesis monooxygenase
LOKO_RS04300	COG2267	carboxylic ester hydrolase activity
LOKO_RS04320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LOKO_RS04335	COG3243	poly(R)-hydroxyalkanoic acid synthase
LOKO_RS04340	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LOKO_RS04345	COG4535	Mg2 and Co2 transporter CorC
LOKO_RS04350	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LOKO_RS04355	COG1702	phosphate starvation-inducible protein PhoH
LOKO_RS04360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LOKO_RS04375	COG4991	sh3 domain protein
LOKO_RS04380	COG0500	methyltransferase
LOKO_RS04390	COG0456	acetyltransferase
LOKO_RS04395	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LOKO_RS04400	COG4208	sulfate ABC transporter
LOKO_RS04410	COG4150	thiosulfate binding
LOKO_RS04420	COG2827	Endonuclease containing a URI domain
LOKO_RS04425	COG0546	phosphoglycolate phosphatase activity
LOKO_RS04440	COG0512	Glutamine amidotransferase of anthranilate synthase
LOKO_RS04445	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LOKO_RS04470	COG0247	lactate metabolic process
LOKO_RS04470	COG0277	FAD linked oxidase domain protein
LOKO_RS04475	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LOKO_RS04485	COG0628	permease
LOKO_RS04505	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LOKO_RS04510	COG0284	orotidine-5'-phosphate decarboxylase activity
LOKO_RS04515	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LOKO_RS04525	COG0776	regulation of translation
LOKO_RS04540	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LOKO_RS04570	COG0322	excinuclease ABC activity
LOKO_RS04575	COG2197	response regulator
LOKO_RS04585	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LOKO_RS04595	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LOKO_RS04600	COG1805	sodium ion transport
LOKO_RS04610	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LOKO_RS04615	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LOKO_RS04620	COG2871	sodium ion transport
LOKO_RS04635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LOKO_RS04675	COG0495	leucyl-tRNA aminoacylation
LOKO_RS04685	COG1596	polysaccharide export
LOKO_RS04690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LOKO_RS04695	COG3206	protein involved in exopolysaccharide biosynthesis
LOKO_RS04695	COG0489	protein tyrosine kinase activity
LOKO_RS04705	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LOKO_RS04705	COG1181	Belongs to the D-alanine--D-alanine ligase family
LOKO_RS04710	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LOKO_RS04730	COG1074	ATP-dependent DNA helicase activity
LOKO_RS04740	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LOKO_RS04745	COG0142	geranyltranstransferase activity
LOKO_RS04750	COG1722	exodeoxyribonuclease VII activity
LOKO_RS04755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LOKO_RS04770	COG1024	Enoyl-CoA hydratase
LOKO_RS04820	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LOKO_RS04830	COG0625	glutathione transferase activity
LOKO_RS04835	COG2814	Major facilitator Superfamily
LOKO_RS04870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LOKO_RS04875	COG1012	belongs to the aldehyde dehydrogenase family
LOKO_RS04880	COG0583	DNA-binding transcription factor activity
LOKO_RS04905	COG0540	Belongs to the ATCase OTCase family
LOKO_RS04915	COG0411	ABC transporter
LOKO_RS04945	COG5564	TIM-barrel signal transduction protein
LOKO_RS04975	COG0559	Belongs to the binding-protein-dependent transport system permease family
LOKO_RS04980	COG5564	TIM-barrel signal transduction protein
LOKO_RS04985	COG5441	Belongs to the UPF0261 family
LOKO_RS04995	COG2204	response regulator
LOKO_RS04995	COG5564	TIM-barrel signal transduction protein
LOKO_RS05000	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LOKO_RS05005	COG1678	Uncharacterized ACR, COG1678
LOKO_RS05015	COG0189	ligase activity
LOKO_RS05025	COG2996	Protein conserved in bacteria
LOKO_RS05030	COG1012	belongs to the aldehyde dehydrogenase family
LOKO_RS05055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LOKO_RS05060	COG3307	-O-antigen
LOKO_RS05095	COG0252	asparaginase activity
LOKO_RS05110	COG0577	efflux transmembrane transporter activity
LOKO_RS05110	COG1136	(ABC) transporter
LOKO_RS05120	COG2807	transmembrane transport
LOKO_RS05130	COG0513	Belongs to the DEAD box helicase family
LOKO_RS05145	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LOKO_RS05145	COG3008	intermembrane lipid transfer
LOKO_RS05150	COG2995	paraquat-inducible protein a
LOKO_RS05160	COG1271	oxidase subunit
LOKO_RS05165	COG1294	oxidase, subunit
LOKO_RS05170	COG4988	ABC transporter
LOKO_RS05175	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LOKO_RS05180	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LOKO_RS05185	COG1858	cytochrome C peroxidase
LOKO_RS05190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LOKO_RS05195	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LOKO_RS05200	COG2252	PERMEase
LOKO_RS05210	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LOKO_RS05215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LOKO_RS05220	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LOKO_RS05225	COG4942	peptidase
LOKO_RS05230	COG0793	Belongs to the peptidase S41A family
LOKO_RS05235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LOKO_RS05240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LOKO_RS05245	COG0006	proline dipeptidase activity
LOKO_RS05250	COG3079	Belongs to the UPF0149 family
LOKO_RS05265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LOKO_RS05270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LOKO_RS05275	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LOKO_RS05280	COG1519	Transferase
LOKO_RS05285	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LOKO_RS05285	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LOKO_RS05295	COG3642	lipopolysaccharide core region biosynthetic process
LOKO_RS05300	COG0438	transferase activity, transferring glycosyl groups
LOKO_RS05305	COG0859	PFAM glycosyl transferase family 9
LOKO_RS05310	COG0463	Glycosyl transferase, family 2
LOKO_RS05325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LOKO_RS05330	COG0752	glycyl-tRNA synthetase alpha subunit
LOKO_RS05335	COG0751	glycine-tRNA ligase activity
LOKO_RS05350	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LOKO_RS05355	COG0592	DNA-directed DNA polymerase activity
LOKO_RS05360	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LOKO_RS05365	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LOKO_RS05370	COG0594	ribonuclease P activity
LOKO_RS05375	COG0706	membrane insertase activity
LOKO_RS05380	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LOKO_RS05385	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LOKO_RS05390	COG2885	chlorophyll binding
LOKO_RS05395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LOKO_RS05400	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LOKO_RS05415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LOKO_RS05420	COG1981	membrane
LOKO_RS05425	COG0038	chloride channel
LOKO_RS05435	COG0316	Belongs to the HesB IscA family
LOKO_RS05440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LOKO_RS05445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LOKO_RS05455	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LOKO_RS05475	COG0418	dihydroorotase activity
LOKO_RS05485	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LOKO_RS05490	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LOKO_RS05515	COG0544	peptidyl-prolyl cis-trans isomerase activity
LOKO_RS05530	COG0318	PFAM AMP-dependent synthetase and ligase
LOKO_RS05540	COG1250	3-hydroxyacyl-CoA dehydrogenase
LOKO_RS05545	COG0183	Belongs to the thiolase family
LOKO_RS05555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LOKO_RS05560	COG1127	ABC transporter
LOKO_RS05565	COG3218	ABC-type transport auxiliary lipoprotein component
LOKO_RS05565	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LOKO_RS05575	COG1802	Transcriptional regulator
LOKO_RS05580	COG3118	belongs to the thioredoxin family
LOKO_RS05590	COG0175	sulfate reduction
LOKO_RS05600	COG1490	D-aminoacyl-tRNA deacylase activity
LOKO_RS05605	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LOKO_RS05610	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LOKO_RS05620	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LOKO_RS05625	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LOKO_RS05635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LOKO_RS05645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LOKO_RS05650	COG0174	glutamine synthetase
LOKO_RS05660	COG3842	ATPase activity
LOKO_RS05665	COG0312	modulator of DNA gyrase
LOKO_RS05670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LOKO_RS05675	COG1660	Displays ATPase and GTPase activities
LOKO_RS05690	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LOKO_RS05695	COG1137	ATPase activity
LOKO_RS05720	COG0530	calcium, potassium:sodium antiporter activity
LOKO_RS05725	COG1127	ABC transporter
LOKO_RS05730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LOKO_RS05735	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LOKO_RS05740	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LOKO_RS05755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LOKO_RS05770	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LOKO_RS05775	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LOKO_RS05780	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LOKO_RS05815	COG0653	protein targeting
LOKO_RS05835	COG5007	Belongs to the BolA IbaG family
LOKO_RS05840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LOKO_RS05845	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LOKO_RS05860	COG2835	tetraacyldisaccharide 4'-kinase activity
LOKO_RS05865	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LOKO_RS05870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LOKO_RS05875	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LOKO_RS05880	COG1530	ribonuclease E activity
LOKO_RS05890	COG0564	pseudouridine synthase activity
LOKO_RS05905	COG0424	maF-like protein
LOKO_RS05910	COG1399	metal-binding, possibly nucleic acid-binding protein
LOKO_RS05915	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LOKO_RS05920	COG0416	fatty acid biosynthetic process
LOKO_RS05935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LOKO_RS05940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LOKO_RS05965	COG0156	8-amino-7-oxononanoate synthase activity
LOKO_RS05970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LOKO_RS05975	COG1040	competence protein
LOKO_RS05980	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LOKO_RS05990	COG0302	gtp cyclohydrolase
LOKO_RS05995	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LOKO_RS06010	COG0138	bifunctional purine biosynthesis protein purh
LOKO_RS06025	COG2264	protein methyltransferase activity
LOKO_RS06090	COG0793	Belongs to the peptidase S41A family
LOKO_RS06095	COG1362	aminopeptidase activity
LOKO_RS06105	COG0012	GTP binding
LOKO_RS06110	COG0193	aminoacyl-tRNA hydrolase activity
LOKO_RS06115	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LOKO_RS06140	COG0511	ligase activity, forming carbon-carbon bonds
LOKO_RS06150	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LOKO_RS06160	COG0205	6-phosphofructokinase activity
LOKO_RS06165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LOKO_RS06175	COG1280	lysine exporter protein (LysE YggA)
LOKO_RS06180	COG0586	Pfam SNARE associated Golgi protein
LOKO_RS06195	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LOKO_RS06200	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LOKO_RS06205	COG0799	negative regulation of ribosome biogenesis
LOKO_RS06210	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LOKO_RS06215	COG0768	penicillin binding
LOKO_RS06220	COG0772	Belongs to the SEDS family
LOKO_RS06225	COG2951	lytic endotransglycosylase activity
LOKO_RS06235	COG1686	Belongs to the peptidase S11 family
LOKO_RS06245	COG0321	lipoyl(octanoyl) transferase activity
LOKO_RS06250	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LOKO_RS06255	COG0583	DNA-binding transcription factor activity
LOKO_RS06260	COG0439	Biotin carboxylase
LOKO_RS06295	COG0488	(ABC) transporter
LOKO_RS06300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LOKO_RS06315	COG1376	ErfK ybiS ycfS ynhG family protein
LOKO_RS06320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LOKO_RS06325	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LOKO_RS06330	COG0066	3-isopropylmalate dehydratase activity
LOKO_RS06335	COG0473	3-isopropylmalate dehydrogenase activity
LOKO_RS06340	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LOKO_RS06365	COG0352	thiamine-phosphate diphosphorylase activity
LOKO_RS06370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LOKO_RS06375	COG2957	Belongs to the agmatine deiminase family
LOKO_RS06380	COG4591	ABC-type transport system involved in lipoprotein release permease component
LOKO_RS06385	COG1136	(ABC) transporter
LOKO_RS06400	COG0811	peptide transport
LOKO_RS06405	COG0848	biopolymer transport protein
LOKO_RS06410	COG1132	(ABC) transporter
LOKO_RS06415	COG1663	tetraacyldisaccharide 4'-kinase activity
LOKO_RS06420	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LOKO_RS06430	COG0135	phosphoribosylanthranilate isomerase activity
LOKO_RS06440	COG0159	tryptophan synthase activity
LOKO_RS06445	COG0159	tryptophan synthase activity
LOKO_RS06450	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LOKO_RS06455	COG0285	dihydrofolate synthase activity
LOKO_RS06480	COG3038	cytochrome b561
LOKO_RS06485	COG2353	YceI-like domain
LOKO_RS06490	COG0534	Mate efflux family protein
LOKO_RS06515	COG2154	pterin-4-alpha-carbinolamine dehydratase
LOKO_RS06525	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LOKO_RS06535	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LOKO_RS06585	COG1295	ribonuclease BN
LOKO_RS06585	COG1959	2 iron, 2 sulfur cluster binding
LOKO_RS06590	COG5002	protein histidine kinase activity
LOKO_RS06595	COG0745	RESPONSE REGULATOR receiver
LOKO_RS06645	COG0489	protein tyrosine kinase activity
LOKO_RS06650	COG0717	Belongs to the dCTP deaminase family
LOKO_RS06655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LOKO_RS06660	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LOKO_RS06665	COG0628	permease
LOKO_RS06670	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LOKO_RS06690	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LOKO_RS06695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LOKO_RS06700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LOKO_RS06705	COG0653	protein targeting
LOKO_RS06710	COG2211	Major facilitator Superfamily
LOKO_RS06720	COG1047	Peptidyl-prolyl cis-trans
LOKO_RS06730	COG2199	diguanylate cyclase activity
LOKO_RS06755	COG0741	lytic transglycosylase activity
LOKO_RS06760	COG0442	prolyl-tRNA aminoacylation
LOKO_RS06775	COG3023	N-Acetylmuramoyl-L-alanine amidase
LOKO_RS06795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LOKO_RS06800	COG2084	Dehydrogenase
LOKO_RS06840	COG2207	Transcriptional regulator
LOKO_RS06865	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LOKO_RS06885	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LOKO_RS06890	COG0740	serine-type endopeptidase activity
LOKO_RS06895	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LOKO_RS06900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LOKO_RS06910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LOKO_RS06915	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LOKO_RS06920	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LOKO_RS06925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LOKO_RS06930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LOKO_RS06935	COG0215	cysteine-tRNA ligase activity
LOKO_RS06945	COG1732	Glycine betaine
LOKO_RS06950	COG1174	glycine betaine transport
LOKO_RS06955	COG1125	glycine betaine transport
LOKO_RS06960	COG1174	glycine betaine transport
LOKO_RS06965	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LOKO_RS06970	COG0022	dehydrogenase e1 component
LOKO_RS07000	COG0583	DNA-binding transcription factor activity
LOKO_RS07010	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LOKO_RS07015	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LOKO_RS07020	COG1984	allophanate hydrolase subunit 2
LOKO_RS07025	COG1960	acyl-CoA dehydrogenase activity
LOKO_RS07030	COG1024	Enoyl-CoA hydratase
LOKO_RS07030	COG1250	3-hydroxyacyl-CoA dehydrogenase
LOKO_RS07040	COG0534	Mate efflux family protein
LOKO_RS07045	COG1960	acyl-CoA dehydrogenase activity
LOKO_RS07060	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LOKO_RS07070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LOKO_RS07075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LOKO_RS07095	COG0417	DNA replication proofreading
LOKO_RS07110	COG2323	membrane
LOKO_RS07115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LOKO_RS07115	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LOKO_RS07125	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LOKO_RS07135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LOKO_RS07160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LOKO_RS07165	COG0765	amino acid transport
LOKO_RS07170	COG1126	abc transporter atp-binding protein
LOKO_RS07175	COG1176	ABC-type spermidine putrescine transport system, permease component I
LOKO_RS07180	COG3842	ATPase activity
LOKO_RS07190	COG1063	alcohol dehydrogenase
LOKO_RS07200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LOKO_RS07200	COG0723	plastoquinol--plastocyanin reductase activity
LOKO_RS07205	COG3685	Protein conserved in bacteria
LOKO_RS07220	COG1396	sequence-specific DNA binding
LOKO_RS07260	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LOKO_RS07275	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LOKO_RS07295	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LOKO_RS07300	COG1074	ATP-dependent DNA helicase activity
LOKO_RS07305	COG2176	DNA-directed DNA polymerase activity
LOKO_RS07305	COG5002	protein histidine kinase activity
LOKO_RS07315	COG5002	protein histidine kinase activity
LOKO_RS07355	COG2986	histidine ammonia-lyase
LOKO_RS07380	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LOKO_RS07420	COG2764	glyoxalase bleomycin resistance protein dioxygenase
LOKO_RS07435	COG2169	Transcriptional regulator
LOKO_RS07435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LOKO_RS07460	COG0477	Major facilitator Superfamily
LOKO_RS07475	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LOKO_RS07490	COG3706	GGDEF domain
LOKO_RS07515	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LOKO_RS07525	COG1846	Transcriptional regulator
LOKO_RS07535	COG3795	YCII-related domain
LOKO_RS07540	COG4941	Belongs to the sigma-70 factor family
LOKO_RS07545	COG5507	3-demethylubiquinone-9 3-methyltransferase
LOKO_RS07560	COG1946	Acyl-CoA thioesterase
LOKO_RS07570	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LOKO_RS07575	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LOKO_RS07575	COG0047	phosphoribosylformylglycinamidine synthase activity
LOKO_RS07585	COG2203	Gaf domain
LOKO_RS07585	COG2199	diguanylate cyclase activity
LOKO_RS07590	COG1017	nitric oxide dioxygenase activity
LOKO_RS07590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LOKO_RS07610	COG0471	metal ion transport
LOKO_RS07615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LOKO_RS07620	COG0508	dehydrogenase complex catalyzes the overall conversion of
LOKO_RS07625	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LOKO_RS07630	COG0280	phosphate acetyltransferase
LOKO_RS07630	COG0281	malic enzyme
LOKO_RS07650	COG0402	S-adenosylhomocysteine deaminase activity
LOKO_RS07660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LOKO_RS07670	COG1067	ATP-dependent peptidase activity
LOKO_RS07695	COG2986	histidine ammonia-lyase
LOKO_RS07705	COG0010	Belongs to the arginase family
LOKO_RS07710	COG1228	amidohydrolase
LOKO_RS07715	COG3314	Sporulation integral membrane protein YlbJ
LOKO_RS07720	COG2188	Transcriptional regulator
LOKO_RS07725	COG1187	pseudouridine synthase activity
LOKO_RS07780	COG0237	dephospho-CoA kinase activity
LOKO_RS07785	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LOKO_RS07795	COG0826	peptidase U32
LOKO_RS07800	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LOKO_RS07805	COG0602	queuosine metabolic process
LOKO_RS07825	COG0556	nucleotide-excision repair
LOKO_RS07830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LOKO_RS07835	COG0028	Belongs to the TPP enzyme family
LOKO_RS07845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LOKO_RS07850	COG0583	DNA-binding transcription factor activity
LOKO_RS07855	COG1051	belongs to the nudix hydrolase family
LOKO_RS07855	COG1056	cytidyltransferase-related domain
LOKO_RS07860	COG1295	ribonuclease BN
LOKO_RS07870	COG1254	Belongs to the acylphosphatase family
LOKO_RS07890	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LOKO_RS07895	COG0459	protein refolding
LOKO_RS07905	COG3956	TIGRFAM MazG family protein
LOKO_RS07910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LOKO_RS07925	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LOKO_RS07930	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LOKO_RS07935	COG1605	Chorismate mutase
LOKO_RS07935	COG0077	Prephenate dehydratase
LOKO_RS07955	COG0824	Thioesterase
LOKO_RS08005	COG0601	transmembrane transport
LOKO_RS08010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LOKO_RS08020	COG0277	FAD linked oxidase domain protein
LOKO_RS08025	COG0697	spore germination
LOKO_RS08030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LOKO_RS08035	COG3829	transcription factor binding
LOKO_RS08045	COG3314	Sporulation integral membrane protein YlbJ
LOKO_RS08055	COG1012	belongs to the aldehyde dehydrogenase family
LOKO_RS08065	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LOKO_RS08070	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LOKO_RS08075	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LOKO_RS08075	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LOKO_RS08090	COG0625	glutathione transferase activity
LOKO_RS08115	COG2204	response regulator
LOKO_RS08120	COG4191	Histidine kinase
LOKO_RS08125	COG1272	protein, Hemolysin III
LOKO_RS08130	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LOKO_RS08135	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LOKO_RS08145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LOKO_RS08155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LOKO_RS08165	COG4235	cytochrome complex assembly
LOKO_RS08175	COG2010	Cytochrome c
LOKO_RS08185	COG3794	PFAM blue (type 1) copper domain protein
LOKO_RS08220	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
LOKO_RS08235	COG4263	nitrous-oxide reductase activity
LOKO_RS08240	COG3901	Regulator of nitric oxide reductase transcription
LOKO_RS08240	COG0348	domain, Protein
LOKO_RS08250	COG1959	2 iron, 2 sulfur cluster binding
LOKO_RS08255	COG2832	Protein of unknown function (DUF454)
LOKO_RS08275	COG3604	Transcriptional regulator
LOKO_RS08280	COG3154	lipid carrier protein
LOKO_RS08300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LOKO_RS08305	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LOKO_RS08315	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LOKO_RS08320	COG0813	purine-nucleoside phosphorylase activity
LOKO_RS08335	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LOKO_RS08350	COG0826	peptidase U32
LOKO_RS08355	COG0826	peptidase U32
LOKO_RS08370	COG2010	Cytochrome c
LOKO_RS08395	COG0535	radical SAM domain protein
LOKO_RS08400	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LOKO_RS08400	COG1648	precorrin-2 dehydrogenase activity
LOKO_RS08420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LOKO_RS08435	COG0714	Associated with various cellular activities
LOKO_RS08475	COG2223	nitrite transmembrane transporter activity
LOKO_RS08485	COG2223	nitrite transmembrane transporter activity
LOKO_RS08490	COG2197	response regulator
LOKO_RS08495	COG3850	Histidine kinase
LOKO_RS08505	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LOKO_RS08510	COG1140	nitrate reductase beta subunit
LOKO_RS08515	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
LOKO_RS08520	COG2181	nitrate reductase activity
LOKO_RS08525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LOKO_RS08530	COG0521	Mo-molybdopterin cofactor biosynthetic process
LOKO_RS08535	COG0303	'Molybdopterin
LOKO_RS08550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LOKO_RS08555	COG1505	serine-type exopeptidase activity
LOKO_RS08565	COG1902	pentaerythritol trinitrate reductase activity
LOKO_RS08565	COG0446	pyridine nucleotide-disulphide oxidoreductase
LOKO_RS08575	COG0747	negative chemotaxis
LOKO_RS08585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LOKO_RS08590	COG0444	Belongs to the ABC transporter superfamily
LOKO_RS08595	COG4608	Belongs to the ABC transporter superfamily
LOKO_RS08605	COG4771	TonB-dependent receptor
LOKO_RS08610	COG1120	ATPase activity
LOKO_RS08650	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LOKO_RS08670	COG2146	nitrite reductase [NAD(P)H] activity
LOKO_RS08670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LOKO_RS08675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LOKO_RS08680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LOKO_RS08685	COG3707	response regulator
LOKO_RS08690	COG0243	molybdopterin cofactor binding
LOKO_RS08695	COG1648	precorrin-2 dehydrogenase activity
LOKO_RS08695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LOKO_RS08705	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LOKO_RS08710	COG3483	tryptophan 2,3-dioxygenase activity
LOKO_RS08720	COG5002	protein histidine kinase activity
LOKO_RS08720	COG5001	Diguanylate cyclase
LOKO_RS08745	COG0678	peroxiredoxin activity
LOKO_RS08760	COG0583	DNA-binding transcription factor activity
LOKO_RS08785	COG0678	peroxiredoxin activity
LOKO_RS08800	COG0179	Fumarylacetoacetate (FAA) hydrolase
LOKO_RS08805	COG2186	Transcriptional regulator
LOKO_RS08810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LOKO_RS08815	COG2223	nitrite transmembrane transporter activity
LOKO_RS08825	COG2989	Protein conserved in bacteria
LOKO_RS08835	COG0739	heme binding
LOKO_RS08840	COG1741	Belongs to the pirin family
LOKO_RS08850	COG0435	Glutathione S-transferase
LOKO_RS08855	COG1671	Belongs to the UPF0178 family
LOKO_RS08875	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LOKO_RS08880	COG0432	Pfam Uncharacterised protein family UPF0047
LOKO_RS08890	COG2226	methyltransferase
LOKO_RS08895	COG1595	DNA-templated transcription, initiation
LOKO_RS08900	COG5662	AntiSigma factor
LOKO_RS08905	COG2226	methyltransferase
LOKO_RS08910	COG2226	methyltransferase
LOKO_RS08930	COG2133	pyrroloquinoline quinone binding
LOKO_RS08935	COG5002	protein histidine kinase activity
LOKO_RS08955	COG0469	pyruvate kinase activity
LOKO_RS08965	COG2084	Dehydrogenase
LOKO_RS08970	COG3622	Belongs to the hyi family
LOKO_RS08975	COG3960	tartronate-semialdehyde synthase activity
LOKO_RS08985	COG3257	ureidoglycine aminohydrolase activity
LOKO_RS09015	COG2351	hydroxyisourate hydrolase activity
LOKO_RS09045	COG1620	l-lactate permease
LOKO_RS09060	COG3842	ATPase activity
LOKO_RS09070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LOKO_RS09080	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LOKO_RS09085	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LOKO_RS09090	COG0632	four-way junction helicase activity
LOKO_RS09095	COG2255	four-way junction helicase activity
LOKO_RS09100	COG0824	Thioesterase
LOKO_RS09120	COG0823	Involved in the tonB-independent uptake of proteins
LOKO_RS09125	COG2885	chlorophyll binding
LOKO_RS09135	COG1028	Short-chain dehydrogenase reductase Sdr
LOKO_RS09150	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LOKO_RS09180	COG3706	GGDEF domain
LOKO_RS09205	COG1558	bacterial-type flagellum-dependent cell motility
LOKO_RS09210	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LOKO_RS09215	COG1749	Flagellar hook protein flgE
LOKO_RS09225	COG4786	Flagellar basal body rod
LOKO_RS09235	COG1706	bacterial-type flagellum-dependent cell motility
LOKO_RS09240	COG3951	Flagellar rod assembly protein muramidase FlgJ
LOKO_RS09240	COG1705	Flagellar rod assembly protein muramidase FlgJ
LOKO_RS09260	COG0384	phenazine biosynthesis protein PhzF
LOKO_RS09280	COG0625	glutathione transferase activity
LOKO_RS09305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LOKO_RS09310	COG0429	hydrolase of the alpha beta-hydrolase fold
LOKO_RS09315	COG0006	proline dipeptidase activity
LOKO_RS09320	COG0288	reversible hydration of carbon dioxide
LOKO_RS09330	COG0456	acetyltransferase
LOKO_RS09335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LOKO_RS09340	COG1917	Cupin 2, conserved barrel domain protein
LOKO_RS09350	COG1320	monovalent cation:proton antiporter activity
LOKO_RS09380	COG0316	Belongs to the HesB IscA family
LOKO_RS09380	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LOKO_RS09390	COG0534	Mate efflux family protein
LOKO_RS09395	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LOKO_RS09405	COG2840	Smr protein MutS2
LOKO_RS09415	COG1393	Belongs to the ArsC family
LOKO_RS09430	COG0259	pyridoxamine-phosphate oxidase activity
LOKO_RS09500	COG3530	Putative quorum-sensing-regulated virulence factor
LOKO_RS09510	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LOKO_RS09515	COG2111	Na H antiporter
LOKO_RS09515	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LOKO_RS09520	COG0651	ATP synthesis coupled electron transport
LOKO_RS09525	COG1007	ATP synthesis coupled electron transport
LOKO_RS09540	COG0133	tryptophan synthase activity
LOKO_RS09555	COG0471	metal ion transport
LOKO_RS09555	COG3273	potassium ion transport
LOKO_RS09560	COG1278	Cold shock
LOKO_RS09565	COG1278	Cold shock
LOKO_RS09580	COG0583	DNA-binding transcription factor activity
LOKO_RS09590	COG0189	ligase activity
LOKO_RS09595	COG0735	belongs to the Fur family
LOKO_RS09600	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LOKO_RS09605	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LOKO_RS09620	COG2166	iron-sulfur cluster assembly
LOKO_RS09640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LOKO_RS09645	COG2274	protein secretion by the type I secretion system
LOKO_RS09675	COG1966	Carbon starvation protein
LOKO_RS09685	COG1234	tRNA 3'-trailer cleavage
LOKO_RS09725	COG0251	oxidation-reduction process
LOKO_RS09750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LOKO_RS09755	COG3501	Rhs element vgr protein
LOKO_RS09770	COG0523	cobalamin synthesis protein
LOKO_RS09775	COG0598	Magnesium transport protein CorA
LOKO_RS09805	COG0583	DNA-binding transcription factor activity
LOKO_RS09815	COG1960	acyl-CoA dehydrogenase activity
LOKO_RS09820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LOKO_RS09825	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LOKO_RS09850	COG1309	transcriptional regulator
LOKO_RS09865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LOKO_RS09875	COG1960	acyl-CoA dehydrogenase activity
LOKO_RS09900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LOKO_RS09905	COG0584	glycerophosphoryl diester phosphodiesterase
LOKO_RS09910	COG0405	Gamma-glutamyltransferase
LOKO_RS09925	COG1686	Belongs to the peptidase S11 family
LOKO_RS09935	COG0697	spore germination
LOKO_RS09940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LOKO_RS09945	COG1121	(ABC) transporter
LOKO_RS09950	COG1321	iron dependent repressor
LOKO_RS09955	COG0352	thiamine-phosphate diphosphorylase activity
LOKO_RS09960	COG0791	NLP P60 protein
LOKO_RS09960	COG1388	LysM domain
LOKO_RS09970	COG3384	dioxygenase
LOKO_RS09980	COG1960	acyl-CoA dehydrogenase activity
LOKO_RS09990	COG0318	PFAM AMP-dependent synthetase and ligase
LOKO_RS09995	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LOKO_RS10010	COG1309	transcriptional regulator
LOKO_RS10015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LOKO_RS10020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LOKO_RS10045	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LOKO_RS10055	COG0315	cyclic pyranopterin monophosphate synthase activity
LOKO_RS10060	COG0303	'Molybdopterin
LOKO_RS10065	COG1763	Mo-molybdopterin cofactor biosynthetic process
LOKO_RS10070	COG0746	molybdenum cofactor guanylyltransferase activity
LOKO_RS10075	COG1917	Cupin 2, conserved barrel domain protein
LOKO_RS10075	COG1396	sequence-specific DNA binding
LOKO_RS10085	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LOKO_RS10090	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LOKO_RS10095	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LOKO_RS10100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LOKO_RS10105	COG2252	PERMEase
LOKO_RS10110	COG0307	riboflavin synthase, alpha
LOKO_RS10115	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LOKO_RS10120	COG2011	ABC-type metal ion transport system permease component
LOKO_RS10130	COG1956	GAF domain-containing protein
LOKO_RS10140	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LOKO_RS10145	COG1349	DNA-binding transcription factor activity
LOKO_RS10165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LOKO_RS10190	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LOKO_RS10195	COG3956	TIGRFAM MazG family protein
LOKO_RS10200	COG2205	protein histidine kinase activity
LOKO_RS10200	COG5002	protein histidine kinase activity
LOKO_RS10200	COG0784	Response regulator, receiver
LOKO_RS10210	COG1381	Involved in DNA repair and RecF pathway recombination
LOKO_RS10215	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LOKO_RS10220	COG0571	ribonuclease III activity
LOKO_RS10230	COG0481	GTPase activity
LOKO_RS10235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LOKO_RS10260	COG1199	ATP-dependent helicase activity
LOKO_RS10265	COG0513	Belongs to the DEAD box helicase family
LOKO_RS10280	COG0708	Exodeoxyribonuclease III
LOKO_RS10290	COG0848	biopolymer transport protein
LOKO_RS10295	COG0811	peptide transport
LOKO_RS10300	COG0811	peptide transport
LOKO_RS10310	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LOKO_RS10320	COG0123	including yeast histone deacetylase and acetoin utilization protein
LOKO_RS10325	COG1396	sequence-specific DNA binding
LOKO_RS10330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LOKO_RS10340	COG0521	Mo-molybdopterin cofactor biosynthetic process
LOKO_RS10345	COG0303	'Molybdopterin
LOKO_RS10355	COG2920	part of a sulfur-relay system
LOKO_RS10370	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LOKO_RS10400	COG3263	regulation of cellular component size
LOKO_RS10405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LOKO_RS10410	COG0596	Alpha beta hydrolase
LOKO_RS10415	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LOKO_RS10425	COG0640	Transcriptional regulator
LOKO_RS10430	COG0616	signal peptide processing
LOKO_RS10440	COG2816	NAD+ diphosphatase activity
LOKO_RS10450	COG0328	RNA-DNA hybrid ribonuclease activity
LOKO_RS10460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LOKO_RS10470	COG4166	transmembrane transport
LOKO_RS10475	COG4174	ABC transporter (Permease)
LOKO_RS10480	COG4239	(ABC) transporter, permease
LOKO_RS10485	COG4172	Belongs to the ABC transporter superfamily
LOKO_RS10515	COG2873	o-acetylhomoserine
LOKO_RS10535	COG1250	3-hydroxyacyl-CoA dehydrogenase
LOKO_RS10535	COG1024	Enoyl-CoA hydratase
LOKO_RS10540	COG1960	acyl-CoA dehydrogenase activity
LOKO_RS10545	COG1960	acyl-CoA dehydrogenase activity
LOKO_RS10580	COG0210	DNA helicase
LOKO_RS10590	COG0084	hydrolase, TatD family'
LOKO_RS10605	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LOKO_RS10610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LOKO_RS10625	COG0583	DNA-binding transcription factor activity
LOKO_RS10655	COG0559	Belongs to the binding-protein-dependent transport system permease family
LOKO_RS10680	COG1397	ADP-ribosylglycohydrolase
LOKO_RS10695	COG1760	l-serine dehydratase
LOKO_RS10700	COG0583	DNA-binding transcription factor activity
LOKO_RS10710	COG0358	DNA primase activity
LOKO_RS10715	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LOKO_RS10725	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LOKO_RS10730	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LOKO_RS10735	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LOKO_RS10740	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LOKO_RS10740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LOKO_RS10755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LOKO_RS10760	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LOKO_RS10765	COG2967	ApaG domain
LOKO_RS10770	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LOKO_RS10775	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LOKO_RS10780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LOKO_RS10780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LOKO_RS10785	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LOKO_RS10790	COG3178	'Phosphotransferase
LOKO_RS10795	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LOKO_RS10800	COG1765	OsmC-like protein
LOKO_RS10805	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LOKO_RS10810	COG0537	adenosine 5'-monophosphoramidase activity
LOKO_RS10815	COG3954	Phosphoribulokinase
LOKO_RS10825	COG0151	Belongs to the GarS family
LOKO_RS10830	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
LOKO_RS10840	COG4067	protein conserved in archaea
LOKO_RS10840	COG0189	ligase activity
LOKO_RS10850	COG2951	lytic endotransglycosylase activity
LOKO_RS10855	COG1320	monovalent cation:proton antiporter activity
LOKO_RS10860	COG2212	antiporter activity
LOKO_RS10865	COG1863	multisubunit Na H antiporter MnhE subunit
LOKO_RS10870	COG0651	ATP synthesis coupled electron transport
LOKO_RS10875	COG1006	Multisubunit Na H antiporter MnhC subunit
LOKO_RS10880	COG2111	Na H antiporter
LOKO_RS10885	COG2111	Na H antiporter
LOKO_RS10885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LOKO_RS10890	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LOKO_RS10890	COG2111	Na H antiporter
LOKO_RS10895	COG1006	Multisubunit Na H antiporter MnhC subunit
LOKO_RS10900	COG0651	ATP synthesis coupled electron transport
LOKO_RS10910	COG2212	antiporter activity
LOKO_RS10935	COG0305	Participates in initiation and elongation during chromosome replication
LOKO_RS10945	COG0359	binds to the 23S rRNA
LOKO_RS10955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LOKO_RS10960	COG0360	Binds together with S18 to 16S ribosomal RNA
LOKO_RS10965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LOKO_RS10990	COG0651	ATP synthesis coupled electron transport
LOKO_RS11000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LOKO_RS11005	COG0651	ATP synthesis coupled electron transport
LOKO_RS11010	COG1006	Multisubunit Na H antiporter MnhC subunit
LOKO_RS11025	COG1320	monovalent cation:proton antiporter activity
LOKO_RS11030	COG2212	antiporter activity
LOKO_RS11055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LOKO_RS11060	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LOKO_RS11065	COG2433	Pfam Transposase IS66
LOKO_RS11075	COG0840	transmembrane signaling receptor activity
LOKO_RS11090	COG3022	response to hydroperoxide
LOKO_RS11095	COG0667	Aldo Keto reductase
LOKO_RS11125	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LOKO_RS11145	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LOKO_RS11150	COG3118	belongs to the thioredoxin family
LOKO_RS11155	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LOKO_RS11165	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LOKO_RS11170	COG1561	YicC-like family, N-terminal region
LOKO_RS11180	COG2203	Gaf domain
LOKO_RS11180	COG3706	GGDEF domain
LOKO_RS11180	COG5001	Diguanylate cyclase
LOKO_RS11180	COG4251	negative regulation of phosphorylation
LOKO_RS11185	COG4191	Histidine kinase
LOKO_RS11185	COG0784	Response regulator, receiver
LOKO_RS11190	COG0194	GDP metabolic process
LOKO_RS11195	COG1758	RNA polymerase activity
LOKO_RS11200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LOKO_RS11210	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LOKO_RS11220	COG0583	DNA-binding transcription factor activity
LOKO_RS11225	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LOKO_RS11245	COG3161	chorismate lyase activity
LOKO_RS11250	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LOKO_RS11265	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
LOKO_RS11270	COG1607	acyl-coa hydrolase
LOKO_RS11275	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LOKO_RS11280	COG0210	DNA helicase
LOKO_RS11285	COG1737	Transcriptional regulator
LOKO_RS11295	COG0733	neurotransmitter:sodium symporter activity
LOKO_RS11300	COG0671	phosphoesterase, PA-phosphatase related
LOKO_RS11305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LOKO_RS11310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LOKO_RS11315	COG1477	protein flavinylation
LOKO_RS11320	COG1968	undecaprenyl-diphosphatase activity
LOKO_RS11335	COG0446	pyridine nucleotide-disulphide oxidoreductase
LOKO_RS11365	COG1509	lysine 2,3-aminomutase activity
LOKO_RS11370	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LOKO_RS11375	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LOKO_RS11385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LOKO_RS11400	COG3842	ATPase activity
LOKO_RS11420	COG0469	pyruvate kinase activity
LOKO_RS11445	COG1737	Transcriptional regulator
LOKO_RS11465	COG0589	response to stress
LOKO_RS11470	COG0659	secondary active sulfate transmembrane transporter activity
LOKO_RS11480	COG4136	ATPase activity
LOKO_RS11485	COG1595	DNA-templated transcription, initiation
LOKO_RS11505	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LOKO_RS11510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LOKO_RS11515	COG1012	belongs to the aldehyde dehydrogenase family
LOKO_RS11535	COG2721	sulfolactate sulfo-lyase activity
LOKO_RS11545	COG0179	Fumarylacetoacetate (FAA) hydrolase
LOKO_RS11550	COG1028	Short-chain dehydrogenase reductase Sdr
LOKO_RS11555	COG1028	Short-chain dehydrogenase reductase Sdr
LOKO_RS11580	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LOKO_RS11595	COG4459	periplasmic nitrate reductase
LOKO_RS11600	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
LOKO_RS11600	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LOKO_RS11610	COG0243	molybdopterin cofactor binding
LOKO_RS11620	COG3005	denitrification pathway
LOKO_RS11630	COG1024	Enoyl-CoA hydratase
LOKO_RS11640	COG3706	GGDEF domain
LOKO_RS11650	COG0840	transmembrane signaling receptor activity
LOKO_RS11670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LOKO_RS11695	COG3706	GGDEF domain
LOKO_RS11695	COG2203	Gaf domain
LOKO_RS11695	COG4251	negative regulation of phosphorylation
LOKO_RS11695	COG5001	Diguanylate cyclase
LOKO_RS11720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LOKO_RS11725	COG3577	Aspartyl protease
LOKO_RS11730	COG1295	ribonuclease BN
LOKO_RS11745	COG1199	ATP-dependent helicase activity
LOKO_RS11775	COG1030	water channel activity
LOKO_RS11785	COG4134	Bacterial extracellular solute-binding protein
LOKO_RS11790	COG4135	transport system, permease component
LOKO_RS11805	COG3842	ATPase activity
LOKO_RS11810	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LOKO_RS11815	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LOKO_RS11820	COG0517	IMP dehydrogenase activity
LOKO_RS11830	COG0668	transmembrane transport
LOKO_RS11840	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LOKO_RS11845	COG1764	response to oxidative stress
LOKO_RS11850	COG0656	L-ascorbic acid biosynthetic process
LOKO_RS11860	COG1515	deoxyribonuclease V activity
LOKO_RS11865	COG0420	3'-5' exonuclease activity
LOKO_RS11885	COG2267	carboxylic ester hydrolase activity
LOKO_RS11890	COG2161	toxin-antitoxin pair type II binding
LOKO_RS11895	COG4115	mRNA cleavage
LOKO_RS11920	COG3177	Filamentation induced by cAMP protein fic
LOKO_RS11925	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
LOKO_RS11930	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LOKO_RS11955	COG0673	inositol 2-dehydrogenase activity
LOKO_RS11965	COG1879	ABC-type sugar transport system periplasmic component
LOKO_RS11970	COG1172	Belongs to the binding-protein-dependent transport system permease family
LOKO_RS11985	COG1846	Transcriptional regulator
LOKO_RS11985	COG1940	carbohydrate kinase activity
LOKO_RS12000	COG0129	dihydroxy-acid dehydratase activity
LOKO_RS12010	COG0306	phosphate transporter
LOKO_RS12015	COG1392	Phosphate transport regulator
LOKO_RS12025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LOKO_RS12030	COG0009	L-threonylcarbamoyladenylate synthase
LOKO_RS12035	COG0613	PHP domain protein
LOKO_RS12040	COG2350	Protein conserved in bacteria
LOKO_RS12045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LOKO_RS12045	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LOKO_RS12050	COG5001	Diguanylate cyclase
LOKO_RS12050	COG5002	protein histidine kinase activity
LOKO_RS12060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LOKO_RS12065	COG3115	cell septum assembly
LOKO_RS12085	COG1132	(ABC) transporter
LOKO_RS12100	COG2133	pyrroloquinoline quinone binding
LOKO_RS12105	COG4191	Histidine kinase
LOKO_RS12110	COG2204	response regulator
LOKO_RS12125	COG1177	transmembrane transport
LOKO_RS12130	COG1176	ABC-type spermidine putrescine transport system, permease component I
LOKO_RS12140	COG3842	ATPase activity
LOKO_RS12155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LOKO_RS12180	COG0697	spore germination
LOKO_RS12185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LOKO_RS12305	COG0154	amidase activity
LOKO_RS12315	COG1335	isochorismatase
LOKO_RS12320	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LOKO_RS12330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LOKO_RS12340	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LOKO_RS12345	COG0066	3-isopropylmalate dehydratase activity
LOKO_RS12360	COG1454	alcohol dehydrogenase
LOKO_RS12390	COG2801	Transposase and inactivated derivatives
LOKO_RS12420	COG0745	RESPONSE REGULATOR receiver
LOKO_RS12425	COG2205	protein histidine kinase activity
LOKO_RS12430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LOKO_RS12445	COG0633	Ferredoxin
LOKO_RS12445	COG3217	Mosc domain protein beta barrel domain protein
LOKO_RS12470	COG1024	Enoyl-CoA hydratase
LOKO_RS12475	COG1250	3-hydroxyacyl-CoA dehydrogenase
LOKO_RS12480	COG0318	PFAM AMP-dependent synthetase and ligase
LOKO_RS12485	COG1960	acyl-CoA dehydrogenase activity
LOKO_RS12520	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LOKO_RS12550	COG2226	methyltransferase
LOKO_RS12555	COG0312	modulator of DNA gyrase
LOKO_RS12565	COG1530	ribonuclease E activity
LOKO_RS12570	COG0424	maF-like protein
LOKO_RS12575	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LOKO_RS12580	COG1792	Involved in formation and maintenance of cell shape
LOKO_RS12585	COG1077	Cell shape determining protein MreB Mrl
LOKO_RS12590	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LOKO_RS12595	COG0154	amidase activity
LOKO_RS12600	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LOKO_RS12610	COG0840	transmembrane signaling receptor activity
LOKO_RS12620	COG1012	belongs to the aldehyde dehydrogenase family
LOKO_RS12625	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LOKO_RS12630	COG0174	glutamine synthetase
LOKO_RS12640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LOKO_RS12645	COG1177	transmembrane transport
LOKO_RS12650	COG1176	ABC-type spermidine putrescine transport system, permease component I
LOKO_RS12670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LOKO_RS12675	COG1643	Atp-dependent helicase
LOKO_RS12680	COG0651	ATP synthesis coupled electron transport
LOKO_RS12695	COG0183	Belongs to the thiolase family
LOKO_RS12705	COG0390	transport system, permease component
LOKO_RS12715	COG0798	PFAM Bile acid sodium symporter
LOKO_RS12735	COG0243	molybdopterin cofactor binding
LOKO_RS12740	COG0437	4 iron, 4 sulfur cluster binding
LOKO_RS12760	COG0640	Transcriptional regulator
LOKO_RS12770	COG2814	Major facilitator Superfamily
LOKO_RS12775	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LOKO_RS12790	COG2853	Lipoprotein
LOKO_RS12800	COG1643	Atp-dependent helicase
LOKO_RS12805	COG0318	PFAM AMP-dependent synthetase and ligase
LOKO_RS12810	COG0121	glutamine amidotransferase
LOKO_RS12830	COG2983	Belongs to the UPF0260 family
LOKO_RS12835	COG3100	YcgL domain-containing protein
LOKO_RS12845	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LOKO_RS12850	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LOKO_RS12855	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LOKO_RS12865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LOKO_RS12870	COG1454	alcohol dehydrogenase
LOKO_RS12885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LOKO_RS12890	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LOKO_RS12900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LOKO_RS12905	COG0183	Belongs to the thiolase family
LOKO_RS12910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LOKO_RS12915	COG0765	amino acid transport
LOKO_RS12950	COG3180	Ammonia monooxygenase
LOKO_RS12955	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LOKO_RS12960	COG3264	Mechanosensitive ion channel
LOKO_RS12960	COG1196	nuclear chromosome segregation
LOKO_RS12970	COG4575	ribosome binding
LOKO_RS12995	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LOKO_RS13000	COG2081	HI0933 family
LOKO_RS13005	COG1858	cytochrome C peroxidase
LOKO_RS13025	COG0778	Nitroreductase
LOKO_RS13030	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LOKO_RS13030	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LOKO_RS13035	COG0842	Transport permease protein
LOKO_RS13040	COG1131	(ABC) transporter
LOKO_RS13075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LOKO_RS13080	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LOKO_RS13085	COG0436	Aminotransferase
LOKO_RS13090	COG0501	Belongs to the peptidase M48B family
LOKO_RS13095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LOKO_RS13115	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LOKO_RS13115	COG0116	Belongs to the methyltransferase superfamily
LOKO_RS13120	COG3130	regulation of translation
LOKO_RS13125	COG0167	dihydroorotate dehydrogenase activity
LOKO_RS13130	COG2902	Dehydrogenase
LOKO_RS13135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LOKO_RS13140	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LOKO_RS13145	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LOKO_RS13155	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LOKO_RS13160	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LOKO_RS13165	COG1674	ftsk spoiiie
LOKO_RS13170	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LOKO_RS13175	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LOKO_RS13180	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LOKO_RS13185	COG0542	response to heat
LOKO_RS13190	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LOKO_RS13205	COG1187	pseudouridine synthase activity
LOKO_RS13230	COG0482	sulfurtransferase activity
LOKO_RS13235	COG2915	High frequency lysogenization protein hflD homolog
LOKO_RS13250	COG2850	peptidyl-arginine hydroxylation
LOKO_RS13265	COG3133	Outer membrane lipoprotein
LOKO_RS13275	COG1047	Peptidyl-prolyl cis-trans
LOKO_RS13280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LOKO_RS13285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LOKO_RS13290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LOKO_RS13295	COG2814	Major facilitator Superfamily
LOKO_RS13300	COG0583	DNA-binding transcription factor activity
LOKO_RS13305	COG0791	NLP P60 protein
LOKO_RS13320	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LOKO_RS13345	COG3106	COG3106 Predicted ATPase
LOKO_RS13350	COG3768	UPF0283 membrane protein
LOKO_RS13355	COG0589	response to stress
LOKO_RS13365	COG3842	ATPase activity
LOKO_RS13425	COG2203	Gaf domain
LOKO_RS13425	COG2199	diguanylate cyclase activity
LOKO_RS13425	COG2200	EAL domain
LOKO_RS13435	COG3039	Transposase
LOKO_RS13470	COG0582	viral genome integration into host DNA
LOKO_RS13490	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LOKO_RS13495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LOKO_RS13510	COG0137	argininosuccinate synthase activity
LOKO_RS13515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LOKO_RS13520	COG5001	Diguanylate cyclase
LOKO_RS13530	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LOKO_RS13535	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LOKO_RS13550	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LOKO_RS13555	COG2200	EAL domain
LOKO_RS13565	COG1191	sigma factor activity
LOKO_RS13585	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LOKO_RS13595	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LOKO_RS13600	COG0745	RESPONSE REGULATOR receiver
LOKO_RS13605	COG0840	transmembrane signaling receptor activity
LOKO_RS13610	COG2201	protein-glutamate methylesterase activity
LOKO_RS13615	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LOKO_RS13620	COG0840	transmembrane signaling receptor activity
LOKO_RS13620	COG0840	transmembrane signaling receptor activity
LOKO_RS13625	COG0840	transmembrane signaling receptor activity
LOKO_RS13625	COG0840	transmembrane signaling receptor activity
LOKO_RS13630	COG0840	transmembrane signaling receptor activity
LOKO_RS13635	COG0835	chemotaxis
LOKO_RS13640	COG0643	Histidine kinase
LOKO_RS13640	COG2198	Histidine kinase
LOKO_RS13645	COG1360	Flagellar Motor Protein
LOKO_RS13685	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LOKO_RS13690	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
LOKO_RS13735	COG0840	transmembrane signaling receptor activity
LOKO_RS13765	COG3344	reverse transcriptase
LOKO_RS13775	COG0045	succinate-CoA ligase (ADP-forming) activity
LOKO_RS13800	COG1053	succinate dehydrogenase
LOKO_RS13805	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LOKO_RS13815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LOKO_RS13845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LOKO_RS13895	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LOKO_RS13925	COG4566	intracellular signal transduction
LOKO_RS13930	COG3239	Fatty acid desaturase
LOKO_RS13950	COG1376	ErfK ybiS ycfS ynhG family protein
LOKO_RS13955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LOKO_RS13960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LOKO_RS13985	COG2217	Heavy metal translocating P-type atpase
LOKO_RS14010	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LOKO_RS14010	COG0519	Catalyzes the synthesis of GMP from XMP
LOKO_RS14020	COG3237	CsbD-like
LOKO_RS14030	COG1570	exodeoxyribonuclease VII activity
LOKO_RS14035	COG2204	response regulator
LOKO_RS14045	COG2205	protein histidine kinase activity
LOKO_RS14050	COG1802	Transcriptional regulator
LOKO_RS14055	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LOKO_RS14060	COG0372	Belongs to the citrate synthase family
LOKO_RS14065	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LOKO_RS14075	COG2079	MmgE PrpD family protein
LOKO_RS14080	COG3088	subunit of a heme lyase
LOKO_RS14095	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LOKO_RS14115	COG4133	protoheme IX ABC transporter activity
LOKO_RS14120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LOKO_RS14125	COG1739	Uncharacterized protein family UPF0029
LOKO_RS14135	COG2059	Chromate
LOKO_RS14140	COG2059	Chromate
LOKO_RS14145	COG3181	Tripartite tricarboxylate transporter family receptor
LOKO_RS14215	COG1802	Transcriptional regulator
LOKO_RS14220	COG2059	Chromate
LOKO_RS14225	COG2059	Chromate
LOKO_RS14230	COG3069	C4-dicarboxylate transmembrane transporter activity
LOKO_RS14240	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
LOKO_RS14275	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LOKO_RS14280	COG0527	aspartate kinase activity
LOKO_RS14285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LOKO_RS14290	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LOKO_RS14295	COG0795	lipopolysaccharide-transporting ATPase activity
LOKO_RS14300	COG0795	lipopolysaccharide-transporting ATPase activity
LOKO_RS14320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LOKO_RS14325	COG1116	anion transmembrane transporter activity
LOKO_RS14330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LOKO_RS14340	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LOKO_RS14350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LOKO_RS14370	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LOKO_RS14385	COG0148	phosphopyruvate hydratase activity
LOKO_RS14390	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LOKO_RS14395	COG0504	CTP synthase activity
LOKO_RS14400	COG0493	'glutamate synthase
LOKO_RS14405	COG0067	glutamate synthase
LOKO_RS14405	COG0069	glutamate synthase activity
LOKO_RS14405	COG0070	glutamate synthase
LOKO_RS14415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LOKO_RS14455	COG0281	malic enzyme
LOKO_RS14460	COG0254	rRNA binding
LOKO_RS14465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LOKO_RS14470	COG0018	arginyl-trna synthetase
LOKO_RS14480	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LOKO_RS14485	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LOKO_RS14495	COG2226	methyltransferase
LOKO_RS14505	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LOKO_RS14510	COG0140	phosphoribosyl-ATP diphosphatase activity
LOKO_RS14515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LOKO_RS14520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LOKO_RS14530	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
LOKO_RS14560	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LOKO_RS14570	COG0248	Ppx GppA phosphatase
LOKO_RS14580	COG0825	malonyl-CoA metabolic process
LOKO_RS14590	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LOKO_RS14595	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LOKO_RS14600	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LOKO_RS14605	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LOKO_RS14610	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LOKO_RS14620	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LOKO_RS14630	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LOKO_RS14635	COG0575	Belongs to the CDS family
LOKO_RS14645	COG0233	cytoplasmic translational termination
LOKO_RS14650	COG0528	UMP kinase activity
LOKO_RS14655	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LOKO_RS14660	COG0052	Belongs to the universal ribosomal protein uS2 family
LOKO_RS14670	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LOKO_RS14675	COG0436	Aminotransferase
LOKO_RS14690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LOKO_RS14700	COG3344	reverse transcriptase
LOKO_RS14720	COG0492	ferredoxin-NADP+ reductase activity
LOKO_RS14750	COG0180	Tryptophanyl-tRNA synthetase
LOKO_RS14755	COG0686	Belongs to the AlaDH PNT family
LOKO_RS14770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LOKO_RS14775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LOKO_RS14780	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LOKO_RS14785	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LOKO_RS14795	COG2003	Belongs to the UPF0758 family
LOKO_RS14800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LOKO_RS14815	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LOKO_RS14820	COG1309	transcriptional regulator
LOKO_RS14830	COG2177	Part of the ABC transporter FtsEX involved in
LOKO_RS14835	COG2884	Cell division ATP-binding protein ftsE
LOKO_RS14840	COG0552	protein localization to endoplasmic reticulum
LOKO_RS14845	COG0742	ribosomal rna small subunit methyltransferase
LOKO_RS14855	COG0456	acetyltransferase
LOKO_RS14865	COG0271	Belongs to the BolA IbaG family
LOKO_RS14870	COG2814	Major facilitator Superfamily
LOKO_RS14880	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LOKO_RS14885	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LOKO_RS14890	COG2067	long-chain fatty acid transport protein
LOKO_RS14895	COG0789	Transcriptional regulator
LOKO_RS14900	COG2217	Heavy metal translocating P-type atpase
LOKO_RS14920	COG0519	Catalyzes the synthesis of GMP from XMP
LOKO_RS14935	COG0174	glutamine synthetase
LOKO_RS14970	COG0471	metal ion transport
LOKO_RS14970	COG3273	potassium ion transport
LOKO_RS14975	COG1024	Enoyl-CoA hydratase
LOKO_RS14985	COG1024	Enoyl-CoA hydratase
LOKO_RS14990	COG1737	Transcriptional regulator
LOKO_RS15005	COG0584	glycerophosphoryl diester phosphodiesterase
LOKO_RS15010	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LOKO_RS15015	COG0659	secondary active sulfate transmembrane transporter activity
LOKO_RS15020	COG1492	cobalamin metabolic process
LOKO_RS15035	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LOKO_RS15040	COG4139	cobalamin transport
LOKO_RS15055	COG2084	Dehydrogenase
LOKO_RS15070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LOKO_RS15080	COG0525	valine-tRNA ligase activity
LOKO_RS15090	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LOKO_RS15120	COG3101	peptidyl-lysine hydroxylation
LOKO_RS15130	COG0022	dehydrogenase e1 component
LOKO_RS15145	COG0084	hydrolase, TatD family'
LOKO_RS15150	COG0488	(ABC) transporter
LOKO_RS15155	COG0589	response to stress
LOKO_RS15175	COG1024	Enoyl-CoA hydratase
LOKO_RS15175	COG1250	3-hydroxyacyl-CoA dehydrogenase
LOKO_RS15180	COG0183	Belongs to the thiolase family
LOKO_RS15195	COG1881	PFAM PEBP family protein
LOKO_RS15200	COG5285	phytanoyl-CoA dioxygenase
LOKO_RS15215	COG4106	trans-aconitate 2-methyltransferase activity
LOKO_RS15220	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LOKO_RS15240	COG0573	inorganic phosphate transmembrane transporter activity
LOKO_RS15250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LOKO_RS15270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LOKO_RS15275	COG0581	inorganic phosphate transmembrane transporter activity
LOKO_RS15280	COG0573	inorganic phosphate transmembrane transporter activity
LOKO_RS15300	COG0590	tRNA wobble adenosine to inosine editing
LOKO_RS15305	COG1283	sodium-dependent phosphate transmembrane transporter activity
LOKO_RS15320	COG1522	sequence-specific DNA binding
LOKO_RS15335	COG0719	Fe-S assembly protein
LOKO_RS15340	COG0396	ATPase activity
LOKO_RS15345	COG0719	Fe-S assembly protein
LOKO_RS15350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LOKO_RS15360	COG2949	membrane
LOKO_RS15370	COG0189	ligase activity
LOKO_RS15375	COG0189	ligase activity
LOKO_RS15375	COG4067	protein conserved in archaea
LOKO_RS15385	COG3098	single-species biofilm formation
LOKO_RS15410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LOKO_RS15435	COG0517	IMP dehydrogenase activity
LOKO_RS15435	COG0617	tRNA 3'-terminal CCA addition
LOKO_RS15435	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LOKO_RS15440	COG0401	homolog of Blt101
LOKO_RS15450	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LOKO_RS15460	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LOKO_RS15500	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LOKO_RS15505	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LOKO_RS15510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LOKO_RS15520	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LOKO_RS15525	COG0588	phosphoglycerate mutase activity
LOKO_RS15535	COG4206	TonB-dependent receptor
LOKO_RS15540	COG2721	sulfolactate sulfo-lyase activity
LOKO_RS15550	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LOKO_RS15555	COG4948	Mandelate Racemase Muconate Lactonizing
LOKO_RS15570	COG4948	Mandelate Racemase Muconate Lactonizing
LOKO_RS15575	COG3734	2-keto-3-deoxy-galactonokinase
LOKO_RS15580	COG0800	Aldolase
LOKO_RS15590	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LOKO_RS15595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LOKO_RS15605	COG0534	Mate efflux family protein
LOKO_RS15610	COG2031	fatty acid transporter
LOKO_RS15615	COG1607	acyl-coa hydrolase
LOKO_RS15665	COG0783	Belongs to the Dps family
LOKO_RS15670	COG2195	Cleaves the N-terminal amino acid of tripeptides
LOKO_RS15680	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LOKO_RS15685	COG1840	ABC-type Fe3 transport system, periplasmic component
LOKO_RS15705	COG0427	acetyl-CoA hydrolase
LOKO_RS15715	COG3550	peptidyl-serine autophosphorylation
LOKO_RS15720	COG1396	sequence-specific DNA binding
LOKO_RS15725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LOKO_RS15735	COG1280	lysine exporter protein (LysE YggA)
LOKO_RS15745	COG1278	Cold shock
LOKO_RS15750	COG0523	cobalamin synthesis protein
LOKO_RS15755	COG1854	S-ribosylhomocysteine lyase activity
LOKO_RS15790	COG0625	glutathione transferase activity
LOKO_RS15805	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LOKO_RS15820	COG2130	NADP-dependent
LOKO_RS15840	COG3706	GGDEF domain
LOKO_RS15845	COG0513	Belongs to the DEAD box helicase family
LOKO_RS15875	COG1402	creatininase
LOKO_RS15880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LOKO_RS15885	COG1073	alpha beta
LOKO_RS15890	COG0217	transcriptional regulatory protein
LOKO_RS15895	COG0006	proline dipeptidase activity
LOKO_RS15920	COG1132	(ABC) transporter
LOKO_RS15930	COG0840	transmembrane signaling receptor activity
LOKO_RS15945	COG0604	alcohol dehydrogenase
LOKO_RS15955	COG1794	racemase activity, acting on amino acids and derivatives
LOKO_RS15960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LOKO_RS15965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LOKO_RS15995	COG4964	Belongs to the GSP D family
LOKO_RS16050	COG2081	HI0933 family
LOKO_RS16080	COG2319	Wd-40 repeat
LOKO_RS16100	COG2766	serine protein kinase
LOKO_RS16105	COG2718	Belongs to the UPF0229 family
LOKO_RS16110	COG2719	SpoVR family
LOKO_RS16120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LOKO_RS16145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LOKO_RS16150	COG4974	Belongs to the 'phage' integrase family
LOKO_RS16155	COG0335	large ribosomal subunit rRNA binding
LOKO_RS16160	COG0336	Belongs to the RNA methyltransferase TrmD family
LOKO_RS16165	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LOKO_RS16170	COG0228	four-way junction DNA binding
LOKO_RS16175	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LOKO_RS16185	COG4536	flavin adenine dinucleotide binding
LOKO_RS16210	COG2925	Exonuclease
LOKO_RS16215	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LOKO_RS16220	COG2894	cell division
LOKO_RS16225	COG0850	regulation of cytokinetic process
LOKO_RS16235	COG1028	Short-chain dehydrogenase reductase Sdr
LOKO_RS16260	COG4245	von Willebrand factor, type A
LOKO_RS16270	COG0519	Catalyzes the synthesis of GMP from XMP
LOKO_RS16275	COG1988	membrane-bound metal-dependent
LOKO_RS16295	COG0346	lactoylglutathione lyase activity
LOKO_RS16305	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LOKO_RS16315	COG0109	protoheme IX farnesyltransferase activity
LOKO_RS16320	COG1612	heme a metabolic process
LOKO_RS16340	COG1845	cytochrome c oxidase, subunit III
LOKO_RS16345	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
LOKO_RS16365	COG1346	cytolysis
LOKO_RS16455	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LOKO_RS16460	COG0583	DNA-binding transcription factor activity
LOKO_RS16465	COG2205	protein histidine kinase activity
LOKO_RS16470	COG0745	RESPONSE REGULATOR receiver
LOKO_RS16475	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LOKO_RS16475	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LOKO_RS16480	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LOKO_RS16500	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LOKO_RS16505	COG1562	ergosterol biosynthetic process
LOKO_RS16515	COG0745	RESPONSE REGULATOR receiver
LOKO_RS16525	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LOKO_RS16565	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LOKO_RS16565	COG1181	Belongs to the D-alanine--D-alanine ligase family
LOKO_RS16570	COG1444	tRNA N-acetyltransferase activity
LOKO_RS16575	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LOKO_RS16585	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LOKO_RS16590	COG1028	Short-chain dehydrogenase reductase Sdr
LOKO_RS16595	COG0671	phosphoesterase, PA-phosphatase related
LOKO_RS16605	COG0346	lactoylglutathione lyase activity
LOKO_RS16615	COG1609	Transcriptional regulator
LOKO_RS16625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LOKO_RS16630	COG1028	Short-chain dehydrogenase reductase Sdr
LOKO_RS16635	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LOKO_RS16645	COG0318	PFAM AMP-dependent synthetase and ligase
LOKO_RS16655	COG1028	Short-chain dehydrogenase reductase Sdr
LOKO_RS16665	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LOKO_RS16675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LOKO_RS16690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LOKO_RS16695	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LOKO_RS16725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LOKO_RS16745	COG1489	DNA binding
LOKO_RS16750	COG0436	Aminotransferase
LOKO_RS16755	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LOKO_RS16760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LOKO_RS16765	COG4191	Histidine kinase
LOKO_RS16775	COG0617	tRNA 3'-terminal CCA addition
LOKO_RS16785	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LOKO_RS16790	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LOKO_RS16795	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LOKO_RS16805	COG1185	polyribonucleotide nucleotidyltransferase activity
LOKO_RS16810	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LOKO_RS16815	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LOKO_RS16820	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LOKO_RS16825	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LOKO_RS16830	COG0195	Participates in both transcription termination and antitermination
LOKO_RS16835	COG0779	Required for maturation of 30S ribosomal subunits
LOKO_RS16850	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LOKO_RS16855	COG0149	triose-phosphate isomerase activity
LOKO_RS16860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LOKO_RS16865	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LOKO_RS16870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LOKO_RS16875	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LOKO_RS16900	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LOKO_RS16910	COG3549	Plasmid maintenance system killer
LOKO_RS16930	COG0484	heat shock protein binding
LOKO_RS16935	COG0443	Heat shock 70 kDa protein
LOKO_RS16940	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LOKO_RS16945	COG0497	DNA recombination
LOKO_RS16955	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LOKO_RS16960	COG2914	Belongs to the UPF0125 (RnfH) family
LOKO_RS16965	COG2867	negative regulation of translational initiation
LOKO_RS16970	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LOKO_RS16980	COG0582	viral genome integration into host DNA
LOKO_RS17020	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LOKO_RS17050	COG1363	Peptidase, m42
LOKO_RS17060	COG1748	Saccharopine dehydrogenase
LOKO_RS17070	COG0527	aspartate kinase activity
LOKO_RS17085	COG0469	pyruvate kinase activity
LOKO_RS17090	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LOKO_RS17095	COG0585	pseudouridine synthase activity
LOKO_RS17100	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LOKO_RS17105	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LOKO_RS17110	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LOKO_RS17130	COG0837	glucose binding
LOKO_RS17135	COG0676	glucose-6-phosphate 1-epimerase activity
LOKO_RS17140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LOKO_RS17145	COG0840	transmembrane signaling receptor activity
LOKO_RS17150	COG1803	Methylglyoxal synthase
LOKO_RS17155	COG0166	Belongs to the GPI family
LOKO_RS17160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LOKO_RS17165	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LOKO_RS17170	COG0668	transmembrane transport
LOKO_RS17185	COG1587	Uroporphyrinogen-III synthase
LOKO_RS17190	COG0181	hydroxymethylbilane synthase activity
LOKO_RS17195	COG0165	Argininosuccinate lyase
LOKO_RS17200	COG0019	diaminopimelate decarboxylase activity
LOKO_RS17205	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LOKO_RS17215	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LOKO_RS17220	COG1011	Hydrolase
LOKO_RS17225	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LOKO_RS17255	COG1238	metal cluster binding
LOKO_RS17260	COG0351	phosphomethylpyrimidine kinase
LOKO_RS17270	COG1490	D-aminoacyl-tRNA deacylase activity
LOKO_RS17275	COG0488	(ABC) transporter
LOKO_RS17285	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LOKO_RS17290	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LOKO_RS17295	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LOKO_RS17300	COG0589	response to stress
LOKO_RS17315	COG1999	signal sequence binding
LOKO_RS17335	COG0583	DNA-binding transcription factor activity
LOKO_RS17345	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LOKO_RS17350	COG2022	thiamine diphosphate biosynthetic process
LOKO_RS17360	COG2363	Small membrane protein
LOKO_RS17370	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LOKO_RS17400	COG0004	ammonium transporteR
LOKO_RS17425	COG5622	Protein required for attachment to host cells
LOKO_RS17435	COG3639	organic phosphonate transmembrane transporter activity
LOKO_RS17450	COG0406	alpha-ribazole phosphatase activity
LOKO_RS17465	COG1126	abc transporter atp-binding protein
LOKO_RS17470	COG0765	amino acid transport
LOKO_RS17475	COG4597	amino acid ABC transporter
LOKO_RS17480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LOKO_RS17485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LOKO_RS17520	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
LOKO_RS17525	COG0277	FAD linked oxidase domain protein
LOKO_RS17525	COG0247	lactate metabolic process
LOKO_RS17535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LOKO_RS17540	COG1024	Enoyl-CoA hydratase
LOKO_RS17545	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LOKO_RS17545	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LOKO_RS17555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LOKO_RS17565	COG1802	Transcriptional regulator
LOKO_RS17570	COG2186	Transcriptional regulator
LOKO_RS17575	COG0277	FAD linked oxidase domain protein
LOKO_RS17580	COG0277	FAD linked oxidase domain protein
LOKO_RS17585	COG0247	lactate metabolic process
LOKO_RS17590	COG3193	protein, possibly involved in utilization of glycolate and propanediol
LOKO_RS17600	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LOKO_RS17610	COG0697	spore germination
LOKO_RS17615	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
LOKO_RS17625	COG0395	ABC-type sugar transport system, permease component
LOKO_RS17635	COG1653	transport
LOKO_RS17640	COG3842	ATPase activity
LOKO_RS17645	COG3153	acetyltransferase
LOKO_RS17645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LOKO_RS17665	COG0583	DNA-binding transcription factor activity
LOKO_RS17670	COG0596	Alpha beta hydrolase
LOKO_RS17675	COG0473	3-isopropylmalate dehydrogenase activity
LOKO_RS17690	COG2226	methyltransferase
LOKO_RS17695	COG3040	lipid binding
LOKO_RS17700	COG2988	succinylglutamate desuccinylase activity
LOKO_RS17715	COG4160	amino acid transport
LOKO_RS17725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LOKO_RS17730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LOKO_RS17755	COG2871	sodium ion transport
LOKO_RS17775	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LOKO_RS17800	COG0569	domain protein
LOKO_RS17805	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LOKO_RS17825	COG3148	PFAM DTW domain containing protein
LOKO_RS17830	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LOKO_RS17880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LOKO_RS17885	COG1121	(ABC) transporter
LOKO_RS17895	COG0803	Belongs to the bacterial solute-binding protein 9 family
LOKO_RS17900	COG1960	acyl-CoA dehydrogenase activity
LOKO_RS17905	COG0183	Belongs to the thiolase family
LOKO_RS17910	COG0318	PFAM AMP-dependent synthetase and ligase
LOKO_RS17915	COG0385	Bile acid
LOKO_RS17940	COG0577	efflux transmembrane transporter activity
LOKO_RS17960	COG0840	transmembrane signaling receptor activity
LOKO_RS17970	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LOKO_RS17980	COG3549	Plasmid maintenance system killer
LOKO_RS17990	COG3706	GGDEF domain
LOKO_RS17995	COG2885	chlorophyll binding
LOKO_RS18005	COG0840	transmembrane signaling receptor activity
LOKO_RS18010	COG1334	flagellar protein FlaG
LOKO_RS18025	COG1766	The M ring may be actively involved in energy transduction
LOKO_RS18030	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LOKO_RS18040	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LOKO_RS18045	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LOKO_RS18060	COG1157	protein secretion by the type III secretion system
LOKO_RS18075	COG1580	Controls the rotational direction of flagella during chemotaxis
LOKO_RS18100	COG1987	bacterial-type flagellum assembly
LOKO_RS18130	COG1256	bacterial-type flagellum assembly
LOKO_RS18140	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LOKO_RS18145	COG0830	nickel cation binding
LOKO_RS18150	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LOKO_RS18155	COG0804	urea catabolic process
LOKO_RS18160	COG0832	Belongs to the urease beta subunit family
LOKO_RS18165	COG0831	urea catabolic process
LOKO_RS18170	COG0829	nickel cation binding
LOKO_RS18195	COG0559	Belongs to the binding-protein-dependent transport system permease family
LOKO_RS18225	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LOKO_RS18230	COG0066	3-isopropylmalate dehydratase activity
LOKO_RS18235	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LOKO_RS18240	COG2188	Transcriptional regulator
LOKO_RS18255	COG1335	isochorismatase
LOKO_RS18270	COG1053	succinate dehydrogenase
LOKO_RS18285	COG2199	diguanylate cyclase activity
LOKO_RS18310	COG0129	dihydroxy-acid dehydratase activity
LOKO_RS18315	COG0745	RESPONSE REGULATOR receiver
LOKO_RS18320	COG2205	protein histidine kinase activity
LOKO_RS18335	COG3639	organic phosphonate transmembrane transporter activity
LOKO_RS18345	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LOKO_RS18350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LOKO_RS18360	COG0709	Synthesizes selenophosphate from selenide and ATP
LOKO_RS18375	COG2239	Acts as a magnesium transporter
LOKO_RS18380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LOKO_RS18385	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LOKO_RS18390	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LOKO_RS18395	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LOKO_RS18400	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LOKO_RS18405	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LOKO_RS18415	COG0356	it plays a direct role in the translocation of protons across the membrane
LOKO_RS18425	COG1475	DNA binding
LOKO_RS18430	COG1192	Involved in chromosome partitioning
LOKO_RS18435	COG0357	Ribosomal RNA small subunit methyltransferase G
LOKO_RS18440	COG0445	tRNA wobble uridine modification
LOKO_RS18450	COG0765	amino acid transport