locus-tag	class	description
HMSLTHF_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HMSLTHF_RS00010	COG0592	DNA-directed DNA polymerase activity
HMSLTHF_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HMSLTHF_RS00025	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HMSLTHF_RS00030	COG0751	glycine-tRNA ligase activity
HMSLTHF_RS00035	COG0752	glycyl-tRNA synthetase alpha subunit
HMSLTHF_RS00040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HMSLTHF_RS00045	COG0859	PFAM glycosyl transferase family 9
HMSLTHF_RS00055	COG0463	Glycosyl transferase, family 2
HMSLTHF_RS00060	COG0859	PFAM glycosyl transferase family 9
HMSLTHF_RS00065	COG0438	transferase activity, transferring glycosyl groups
HMSLTHF_RS00070	COG3642	lipopolysaccharide core region biosynthetic process
HMSLTHF_RS00080	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HMSLTHF_RS00080	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HMSLTHF_RS00085	COG1519	Transferase
HMSLTHF_RS00090	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HMSLTHF_RS00095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HMSLTHF_RS00100	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HMSLTHF_RS00120	COG0006	proline dipeptidase activity
HMSLTHF_RS00125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HMSLTHF_RS00130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HMSLTHF_RS00135	COG0793	Belongs to the peptidase S41A family
HMSLTHF_RS00140	COG4942	peptidase
HMSLTHF_RS00145	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HMSLTHF_RS00150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HMSLTHF_RS00155	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HMSLTHF_RS00160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HMSLTHF_RS00165	COG2996	Protein conserved in bacteria
HMSLTHF_RS00170	COG0189	ligase activity
HMSLTHF_RS00175	COG1678	Uncharacterized ACR, COG1678
HMSLTHF_RS00180	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HMSLTHF_RS00185	COG0540	Belongs to the ATCase OTCase family
HMSLTHF_RS00220	COG0023	Translation Initiation Factor
HMSLTHF_RS00225	COG0546	phosphoglycolate phosphatase activity
HMSLTHF_RS00245	COG0126	phosphoglycerate kinase activity
HMSLTHF_RS00250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HMSLTHF_RS00255	COG1346	cytolysis
HMSLTHF_RS00265	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HMSLTHF_RS00270	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HMSLTHF_RS00275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HMSLTHF_RS00305	COG0339	signal peptide processing
HMSLTHF_RS00310	COG0733	neurotransmitter:sodium symporter activity
HMSLTHF_RS00315	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HMSLTHF_RS00340	COG1304	FMN binding
HMSLTHF_RS00365	COG2747	anti-sigma28 factor FlgM
HMSLTHF_RS00380	COG1558	bacterial-type flagellum-dependent cell motility
HMSLTHF_RS00395	COG4787	bacterial-type flagellum-dependent cell motility
HMSLTHF_RS00410	COG1706	bacterial-type flagellum-dependent cell motility
HMSLTHF_RS00435	COG1987	bacterial-type flagellum assembly
HMSLTHF_RS00490	COG1766	The M ring may be actively involved in energy transduction
HMSLTHF_RS00500	COG1334	flagellar protein FlaG
HMSLTHF_RS00505	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HMSLTHF_RS00545	COG1360	Flagellar Motor Protein
HMSLTHF_RS00555	COG0835	chemotaxis
HMSLTHF_RS00565	COG0840	transmembrane signaling receptor activity
HMSLTHF_RS00565	COG0840	transmembrane signaling receptor activity
HMSLTHF_RS00570	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HMSLTHF_RS00575	COG2201	protein-glutamate methylesterase activity
HMSLTHF_RS00580	COG0840	transmembrane signaling receptor activity
HMSLTHF_RS00585	COG0745	RESPONSE REGULATOR receiver
HMSLTHF_RS00600	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HMSLTHF_RS00620	COG1191	sigma factor activity
HMSLTHF_RS00625	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HMSLTHF_RS00665	COG1230	cation diffusion facilitator family transporter
HMSLTHF_RS00670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HMSLTHF_RS00670	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HMSLTHF_RS00675	COG0739	heme binding
HMSLTHF_RS00685	COG0789	Transcriptional regulator
HMSLTHF_RS00690	COG2217	Heavy metal translocating P-type atpase
HMSLTHF_RS00700	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HMSLTHF_RS00705	COG1376	ErfK ybiS ycfS ynhG family protein
HMSLTHF_RS00705	COG1388	LysM domain
HMSLTHF_RS00740	COG2814	Major facilitator Superfamily
HMSLTHF_RS00745	COG0629	single-stranded DNA binding
HMSLTHF_RS00765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HMSLTHF_RS00785	COG1090	epimerase
HMSLTHF_RS00790	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HMSLTHF_RS00795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HMSLTHF_RS00835	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HMSLTHF_RS00835	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HMSLTHF_RS00840	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HMSLTHF_RS00875	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HMSLTHF_RS00880	COG0081	regulation of translation
HMSLTHF_RS00885	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HMSLTHF_RS00890	COG0222	ribosome binding
HMSLTHF_RS00895	COG0085	RNA polymerase activity
HMSLTHF_RS00900	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HMSLTHF_RS00905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HMSLTHF_RS00910	COG0049	tRNA binding
HMSLTHF_RS00915	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HMSLTHF_RS00920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HMSLTHF_RS00925	COG0051	transcription antitermination factor activity, RNA binding
HMSLTHF_RS00930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HMSLTHF_RS00935	COG0088	Forms part of the polypeptide exit tunnel
HMSLTHF_RS00940	COG0089	rRNA binding
HMSLTHF_RS00945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HMSLTHF_RS00950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HMSLTHF_RS00955	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HMSLTHF_RS00960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HMSLTHF_RS00965	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HMSLTHF_RS00970	COG0255	Belongs to the universal ribosomal protein uL29 family
HMSLTHF_RS00975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HMSLTHF_RS00980	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HMSLTHF_RS00985	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HMSLTHF_RS00990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HMSLTHF_RS00995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HMSLTHF_RS01000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HMSLTHF_RS01005	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HMSLTHF_RS01010	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HMSLTHF_RS01015	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HMSLTHF_RS01020	COG1841	ribosomal large subunit assembly
HMSLTHF_RS01025	COG0200	Binds to the 23S rRNA
HMSLTHF_RS01035	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HMSLTHF_RS01040	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HMSLTHF_RS01045	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HMSLTHF_RS01050	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HMSLTHF_RS01055	COG0202	RNA polymerase activity
HMSLTHF_RS01060	COG0203	ribosomal protein L17
HMSLTHF_RS01065	COG1686	Belongs to the peptidase S11 family
HMSLTHF_RS01070	COG0697	spore germination
HMSLTHF_RS01075	COG3384	dioxygenase
HMSLTHF_RS01085	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS01090	COG0352	thiamine-phosphate diphosphorylase activity
HMSLTHF_RS01095	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HMSLTHF_RS01115	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMSLTHF_RS01125	COG1121	(ABC) transporter
HMSLTHF_RS01160	COG2204	response regulator
HMSLTHF_RS01175	COG5510	response to toxic substance
HMSLTHF_RS01195	COG3842	ATPase activity
HMSLTHF_RS01205	COG1175	transmembrane transport
HMSLTHF_RS01225	COG3012	SEC-C Motif Domain Protein
HMSLTHF_RS01240	COG2827	Endonuclease containing a URI domain
HMSLTHF_RS01270	COG4974	Belongs to the 'phage' integrase family
HMSLTHF_RS01405	COG0142	geranyltranstransferase activity
HMSLTHF_RS01410	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HMSLTHF_RS01415	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HMSLTHF_RS01420	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HMSLTHF_RS01425	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HMSLTHF_RS01445	COG0745	RESPONSE REGULATOR receiver
HMSLTHF_RS01450	COG2205	protein histidine kinase activity
HMSLTHF_RS01460	COG5001	Diguanylate cyclase
HMSLTHF_RS01460	COG3300	MHYT domain
HMSLTHF_RS01475	COG3639	organic phosphonate transmembrane transporter activity
HMSLTHF_RS01490	COG1388	LysM domain
HMSLTHF_RS01490	COG0791	NLP P60 protein
HMSLTHF_RS01525	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HMSLTHF_RS01535	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HMSLTHF_RS01540	COG2867	negative regulation of translational initiation
HMSLTHF_RS01545	COG2914	Belongs to the UPF0125 (RnfH) family
HMSLTHF_RS01550	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HMSLTHF_RS01560	COG0497	DNA recombination
HMSLTHF_RS01565	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HMSLTHF_RS01570	COG0443	Heat shock 70 kDa protein
HMSLTHF_RS01575	COG0484	heat shock protein binding
HMSLTHF_RS01585	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HMSLTHF_RS01610	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HMSLTHF_RS01615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HMSLTHF_RS01620	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HMSLTHF_RS01625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMSLTHF_RS01630	COG0149	triose-phosphate isomerase activity
HMSLTHF_RS01635	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HMSLTHF_RS01650	COG0779	Required for maturation of 30S ribosomal subunits
HMSLTHF_RS01655	COG0195	Participates in both transcription termination and antitermination
HMSLTHF_RS01660	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HMSLTHF_RS01665	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HMSLTHF_RS01670	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HMSLTHF_RS01675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HMSLTHF_RS01680	COG1185	polyribonucleotide nucleotidyltransferase activity
HMSLTHF_RS01695	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HMSLTHF_RS01700	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HMSLTHF_RS01705	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HMSLTHF_RS01710	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HMSLTHF_RS01715	COG0617	tRNA 3'-terminal CCA addition
HMSLTHF_RS01720	COG2204	response regulator
HMSLTHF_RS01725	COG3852	Histidine kinase
HMSLTHF_RS01735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HMSLTHF_RS01740	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HMSLTHF_RS01745	COG0436	Aminotransferase
HMSLTHF_RS01750	COG1489	DNA binding
HMSLTHF_RS01765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HMSLTHF_RS01795	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HMSLTHF_RS01800	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HMSLTHF_RS01835	COG3022	response to hydroperoxide
HMSLTHF_RS01840	COG0667	Aldo Keto reductase
HMSLTHF_RS01880	COG1403	HNH endonuclease
HMSLTHF_RS01890	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HMSLTHF_RS01895	COG3118	belongs to the thioredoxin family
HMSLTHF_RS01925	COG1959	2 iron, 2 sulfur cluster binding
HMSLTHF_RS01930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HMSLTHF_RS01930	COG1017	nitric oxide dioxygenase activity
HMSLTHF_RS01955	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HMSLTHF_RS01960	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HMSLTHF_RS01965	COG0732	type I restriction modification DNA specificity domain
HMSLTHF_RS01975	COG1028	Short-chain dehydrogenase reductase Sdr
HMSLTHF_RS01985	COG0850	regulation of cytokinetic process
HMSLTHF_RS01990	COG2894	cell division
HMSLTHF_RS01995	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HMSLTHF_RS02000	COG2925	Exonuclease
HMSLTHF_RS02005	COG1025	Belongs to the peptidase M16 family
HMSLTHF_RS02025	COG4536	flavin adenine dinucleotide binding
HMSLTHF_RS02030	COG4137	Cytochrome C assembly protein
HMSLTHF_RS02035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HMSLTHF_RS02040	COG0228	four-way junction DNA binding
HMSLTHF_RS02045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HMSLTHF_RS02050	COG0336	Belongs to the RNA methyltransferase TrmD family
HMSLTHF_RS02055	COG0335	large ribosomal subunit rRNA binding
HMSLTHF_RS02060	COG4974	Belongs to the 'phage' integrase family
HMSLTHF_RS02065	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HMSLTHF_RS02080	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HMSLTHF_RS02090	COG2217	Heavy metal translocating P-type atpase
HMSLTHF_RS02100	COG2067	long-chain fatty acid transport protein
HMSLTHF_RS02110	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HMSLTHF_RS02120	COG2814	Major facilitator Superfamily
HMSLTHF_RS02125	COG0271	Belongs to the BolA IbaG family
HMSLTHF_RS02145	COG0742	ribosomal rna small subunit methyltransferase
HMSLTHF_RS02150	COG0552	protein localization to endoplasmic reticulum
HMSLTHF_RS02155	COG2884	Cell division ATP-binding protein ftsE
HMSLTHF_RS02160	COG2177	Part of the ABC transporter FtsEX involved in
HMSLTHF_RS02170	COG1309	transcriptional regulator
HMSLTHF_RS02175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HMSLTHF_RS02190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HMSLTHF_RS02195	COG2003	Belongs to the UPF0758 family
HMSLTHF_RS02200	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HMSLTHF_RS02205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HMSLTHF_RS02210	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HMSLTHF_RS02215	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HMSLTHF_RS02235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HMSLTHF_RS02250	COG0436	Aminotransferase
HMSLTHF_RS02255	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HMSLTHF_RS02260	COG0024	Methionine aminopeptidase
HMSLTHF_RS02265	COG0052	Belongs to the universal ribosomal protein uS2 family
HMSLTHF_RS02270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HMSLTHF_RS02275	COG0528	UMP kinase activity
HMSLTHF_RS02280	COG0233	cytoplasmic translational termination
HMSLTHF_RS02295	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HMSLTHF_RS02315	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HMSLTHF_RS02320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HMSLTHF_RS02325	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HMSLTHF_RS02330	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HMSLTHF_RS02335	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HMSLTHF_RS02345	COG0825	malonyl-CoA metabolic process
HMSLTHF_RS02350	COG0037	tRNA processing
HMSLTHF_RS02365	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HMSLTHF_RS02395	COG1988	membrane-bound metal-dependent
HMSLTHF_RS02400	COG0346	lactoylglutathione lyase activity
HMSLTHF_RS02410	COG0525	valine-tRNA ligase activity
HMSLTHF_RS02425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HMSLTHF_RS02430	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HMSLTHF_RS02435	COG0795	lipopolysaccharide-transporting ATPase activity
HMSLTHF_RS02440	COG0795	lipopolysaccharide-transporting ATPase activity
HMSLTHF_RS02460	COG1966	Carbon starvation protein
HMSLTHF_RS02465	COG2032	superoxide dismutase activity
HMSLTHF_RS02480	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HMSLTHF_RS02490	COG3453	Protein conserved in bacteria
HMSLTHF_RS02490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HMSLTHF_RS02505	COG0523	cobalamin synthesis protein
HMSLTHF_RS02515	COG2226	methyltransferase
HMSLTHF_RS02535	COG0531	amino acid
HMSLTHF_RS02545	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HMSLTHF_RS02550	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HMSLTHF_RS02560	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HMSLTHF_RS02565	COG2226	methyltransferase
HMSLTHF_RS02565	COG1073	alpha beta
HMSLTHF_RS02575	COG0156	8-amino-7-oxononanoate synthase activity
HMSLTHF_RS02580	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HMSLTHF_RS02605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HMSLTHF_RS02610	COG0569	domain protein
HMSLTHF_RS02615	COG3360	Dodecin
HMSLTHF_RS02625	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HMSLTHF_RS02630	COG0242	peptide deformylase activity
HMSLTHF_RS02645	COG0758	DNA mediated transformation
HMSLTHF_RS02650	COG0009	L-threonylcarbamoyladenylate synthase
HMSLTHF_RS02655	COG0408	coproporphyrinogen oxidase activity
HMSLTHF_RS02660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HMSLTHF_RS02685	COG1160	GTP binding
HMSLTHF_RS02695	COG2976	Protein conserved in bacteria
HMSLTHF_RS02700	COG0124	histidyl-tRNA synthetase
HMSLTHF_RS02705	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HMSLTHF_RS02715	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HMSLTHF_RS02720	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HMSLTHF_RS02725	COG0105	UTP biosynthetic process
HMSLTHF_RS02735	COG1104	cysteine desulfurase activity
HMSLTHF_RS02745	COG1045	serine acetyltransferase
HMSLTHF_RS02770	COG1862	Preprotein translocase
HMSLTHF_RS02775	COG0343	queuine tRNA-ribosyltransferase activity
HMSLTHF_RS02780	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HMSLTHF_RS02790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HMSLTHF_RS02830	COG0110	maltose O-acetyltransferase activity
HMSLTHF_RS02835	COG1715	Restriction endonuclease
HMSLTHF_RS02890	COG1794	racemase activity, acting on amino acids and derivatives
HMSLTHF_RS02910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HMSLTHF_RS02915	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HMSLTHF_RS02920	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HMSLTHF_RS02925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMSLTHF_RS02940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HMSLTHF_RS02945	COG0348	domain, Protein
HMSLTHF_RS02965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HMSLTHF_RS02970	COG1960	acyl-CoA dehydrogenase activity
HMSLTHF_RS02975	COG1802	Transcriptional regulator
HMSLTHF_RS02980	COG0579	oxidoreductase
HMSLTHF_RS03030	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HMSLTHF_RS03035	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HMSLTHF_RS03040	COG0070	glutamate synthase
HMSLTHF_RS03040	COG0069	glutamate synthase activity
HMSLTHF_RS03040	COG0067	glutamate synthase
HMSLTHF_RS03045	COG0493	'glutamate synthase
HMSLTHF_RS03050	COG0504	CTP synthase activity
HMSLTHF_RS03055	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HMSLTHF_RS03060	COG0148	phosphopyruvate hydratase activity
HMSLTHF_RS03065	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HMSLTHF_RS03070	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HMSLTHF_RS03075	COG1546	Belongs to the CinA family
HMSLTHF_RS03080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HMSLTHF_RS03110	COG2608	mercury ion transmembrane transporter activity
HMSLTHF_RS03115	COG2608	mercury ion transmembrane transporter activity
HMSLTHF_RS03165	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HMSLTHF_RS03170	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HMSLTHF_RS03195	COG2217	Heavy metal translocating P-type atpase
HMSLTHF_RS03245	COG0785	Cytochrome C biogenesis protein
HMSLTHF_RS03255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HMSLTHF_RS03315	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HMSLTHF_RS03325	COG0398	Pfam SNARE associated Golgi protein
HMSLTHF_RS03345	COG0450	alkyl hydroperoxide reductase
HMSLTHF_RS03350	COG0785	Cytochrome C biogenesis protein
HMSLTHF_RS03375	COG3667	copper resistance
HMSLTHF_RS03385	COG3850	Histidine kinase
HMSLTHF_RS03385	COG5002	protein histidine kinase activity
HMSLTHF_RS03390	COG0745	RESPONSE REGULATOR receiver
HMSLTHF_RS03450	COG2814	Major facilitator Superfamily
HMSLTHF_RS03495	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HMSLTHF_RS03505	COG2137	regulation of response to DNA damage stimulus
HMSLTHF_RS03510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HMSLTHF_RS03515	COG0527	aspartate kinase activity
HMSLTHF_RS03520	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HMSLTHF_RS03555	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HMSLTHF_RS03560	COG1739	Uncharacterized protein family UPF0029
HMSLTHF_RS03570	COG4133	protoheme IX ABC transporter activity
HMSLTHF_RS03590	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HMSLTHF_RS03595	COG1138	Cytochrome C-type biogenesis protein
HMSLTHF_RS03605	COG3088	subunit of a heme lyase
HMSLTHF_RS03615	COG1196	nuclear chromosome segregation
HMSLTHF_RS03620	COG3115	cell septum assembly
HMSLTHF_RS03625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HMSLTHF_RS03630	COG3089	Belongs to the UPF0270 family
HMSLTHF_RS03635	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HMSLTHF_RS03635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HMSLTHF_RS03640	COG2350	Protein conserved in bacteria
HMSLTHF_RS03645	COG0613	PHP domain protein
HMSLTHF_RS03650	COG0009	L-threonylcarbamoyladenylate synthase
HMSLTHF_RS03655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HMSLTHF_RS03665	COG1392	Phosphate transport regulator
HMSLTHF_RS03670	COG0306	phosphate transporter
HMSLTHF_RS03700	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HMSLTHF_RS03700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HMSLTHF_RS03710	COG1570	exodeoxyribonuclease VII activity
HMSLTHF_RS03715	COG1283	sodium-dependent phosphate transmembrane transporter activity
HMSLTHF_RS03730	COG0519	Catalyzes the synthesis of GMP from XMP
HMSLTHF_RS03730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HMSLTHF_RS03740	COG0789	Transcriptional regulator
HMSLTHF_RS03745	COG1230	cation diffusion facilitator family transporter
HMSLTHF_RS03805	COG2354	Protein conserved in bacteria
HMSLTHF_RS03840	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS03845	COG2249	NAD(P)H dehydrogenase (quinone) activity
HMSLTHF_RS03860	COG0318	PFAM AMP-dependent synthetase and ligase
HMSLTHF_RS03860	COG0204	Acyl-transferase
HMSLTHF_RS03865	COG2226	methyltransferase
HMSLTHF_RS03870	COG1278	Cold shock
HMSLTHF_RS03880	COG1301	dicarboxylic acid transport
HMSLTHF_RS03895	COG4772	TonB-dependent receptor
HMSLTHF_RS03905	COG2130	NADP-dependent
HMSLTHF_RS03910	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HMSLTHF_RS03935	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS03945	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS03950	COG4615	Cyclic peptide transporter
HMSLTHF_RS03955	COG1120	ATPase activity
HMSLTHF_RS03965	COG1595	DNA-templated transcription, initiation
HMSLTHF_RS04015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HMSLTHF_RS04060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMSLTHF_RS04075	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HMSLTHF_RS04080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HMSLTHF_RS04080	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HMSLTHF_RS04085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HMSLTHF_RS04100	COG1115	amino acid carrier protein
HMSLTHF_RS04115	COG2267	carboxylic ester hydrolase activity
HMSLTHF_RS04125	COG2146	nitrite reductase [NAD(P)H] activity
HMSLTHF_RS04125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HMSLTHF_RS04130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HMSLTHF_RS04135	COG0243	molybdopterin cofactor binding
HMSLTHF_RS04150	COG3547	Transposase (IS116 IS110 IS902 family)
HMSLTHF_RS04160	COG2059	Chromate
HMSLTHF_RS04165	COG2059	Chromate
HMSLTHF_RS04170	COG1802	Transcriptional regulator
HMSLTHF_RS04185	COG1280	lysine exporter protein (LysE YggA)
HMSLTHF_RS04190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMSLTHF_RS04195	COG4221	oxidoreductase activity
HMSLTHF_RS04200	COG3707	response regulator
HMSLTHF_RS04205	COG2223	nitrite transmembrane transporter activity
HMSLTHF_RS04225	COG2989	Protein conserved in bacteria
HMSLTHF_RS04230	COG0739	heme binding
HMSLTHF_RS04235	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS04240	COG0435	Glutathione S-transferase
HMSLTHF_RS04255	COG1515	deoxyribonuclease V activity
HMSLTHF_RS04260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HMSLTHF_RS04260	COG0519	Catalyzes the synthesis of GMP from XMP
HMSLTHF_RS04270	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HMSLTHF_RS04280	COG0668	transmembrane transport
HMSLTHF_RS04310	COG0673	inositol 2-dehydrogenase activity
HMSLTHF_RS04315	COG1653	transport
HMSLTHF_RS04320	COG1609	Transcriptional regulator
HMSLTHF_RS04330	COG0813	purine-nucleoside phosphorylase activity
HMSLTHF_RS04335	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HMSLTHF_RS04340	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HMSLTHF_RS04350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HMSLTHF_RS04360	COG1349	DNA-binding transcription factor activity
HMSLTHF_RS04365	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HMSLTHF_RS04370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HMSLTHF_RS04375	COG1845	cytochrome c oxidase, subunit III
HMSLTHF_RS04385	COG0109	protoheme IX farnesyltransferase activity
HMSLTHF_RS04390	COG0857	belongs to the CobB CobQ family
HMSLTHF_RS04390	COG0280	phosphate acetyltransferase
HMSLTHF_RS04395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HMSLTHF_RS04410	COG1566	PFAM secretion protein HlyD family protein
HMSLTHF_RS04445	COG0477	Major facilitator Superfamily
HMSLTHF_RS04455	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HMSLTHF_RS04545	COG2161	toxin-antitoxin pair type II binding
HMSLTHF_RS04555	COG4115	mRNA cleavage
HMSLTHF_RS04560	COG2161	toxin-antitoxin pair type II binding
HMSLTHF_RS04570	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HMSLTHF_RS04570	COG0662	Cupin 2, conserved barrel domain protein
HMSLTHF_RS04605	COG1960	acyl-CoA dehydrogenase activity
HMSLTHF_RS04610	COG0318	PFAM AMP-dependent synthetase and ligase
HMSLTHF_RS04615	COG1250	3-hydroxyacyl-CoA dehydrogenase
HMSLTHF_RS04620	COG1024	Enoyl-CoA hydratase
HMSLTHF_RS04630	COG0625	glutathione transferase activity
HMSLTHF_RS04635	COG4681	YaeQ
HMSLTHF_RS04655	COG4774	siderophore transport
HMSLTHF_RS04665	COG0625	glutathione transferase activity
HMSLTHF_RS04675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HMSLTHF_RS04685	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HMSLTHF_RS04690	COG3265	gluconokinase activity
HMSLTHF_RS04695	COG1609	Transcriptional regulator
HMSLTHF_RS04710	COG1764	response to oxidative stress
HMSLTHF_RS04715	COG1376	ErfK ybiS ycfS ynhG family protein
HMSLTHF_RS04715	COG1388	LysM domain
HMSLTHF_RS04720	COG4566	intracellular signal transduction
HMSLTHF_RS04725	COG2205	protein histidine kinase activity
HMSLTHF_RS04725	COG0745	RESPONSE REGULATOR receiver
HMSLTHF_RS04725	COG4191	Histidine kinase
HMSLTHF_RS04745	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HMSLTHF_RS04745	COG3323	Protein of unknown function (DUF1653)
HMSLTHF_RS04755	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HMSLTHF_RS04775	COG3604	Transcriptional regulator
HMSLTHF_RS04780	COG1538	Outer membrane efflux protein
HMSLTHF_RS04785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HMSLTHF_RS04820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HMSLTHF_RS04835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HMSLTHF_RS04850	COG2084	Dehydrogenase
HMSLTHF_RS04860	COG2009	succinate dehydrogenase
HMSLTHF_RS04865	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HMSLTHF_RS04870	COG1053	succinate dehydrogenase
HMSLTHF_RS04895	COG0045	succinate-CoA ligase (ADP-forming) activity
HMSLTHF_RS04910	COG0438	transferase activity, transferring glycosyl groups
HMSLTHF_RS04930	COG3768	UPF0283 membrane protein
HMSLTHF_RS04935	COG3106	COG3106 Predicted ATPase
HMSLTHF_RS04945	COG0676	glucose-6-phosphate 1-epimerase activity
HMSLTHF_RS04960	COG0791	NLP P60 protein
HMSLTHF_RS04965	COG2814	Major facilitator Superfamily
HMSLTHF_RS04975	COG0444	Belongs to the ABC transporter superfamily
HMSLTHF_RS04980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMSLTHF_RS04985	COG0601	transmembrane transport
HMSLTHF_RS04990	COG0747	negative chemotaxis
HMSLTHF_RS04995	COG0864	Transcriptional regulator
HMSLTHF_RS05025	COG2850	peptidyl-arginine hydroxylation
HMSLTHF_RS05035	COG2915	High frequency lysogenization protein hflD homolog
HMSLTHF_RS05040	COG0482	sulfurtransferase activity
HMSLTHF_RS05060	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HMSLTHF_RS05065	COG0542	response to heat
HMSLTHF_RS05070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HMSLTHF_RS05075	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HMSLTHF_RS05080	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HMSLTHF_RS05085	COG1674	ftsk spoiiie
HMSLTHF_RS05090	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HMSLTHF_RS05095	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HMSLTHF_RS05105	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HMSLTHF_RS05110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HMSLTHF_RS05115	COG2902	Dehydrogenase
HMSLTHF_RS05120	COG0167	dihydroorotate dehydrogenase activity
HMSLTHF_RS05125	COG3130	regulation of translation
HMSLTHF_RS05130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HMSLTHF_RS05130	COG0116	Belongs to the methyltransferase superfamily
HMSLTHF_RS05145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HMSLTHF_RS05150	COG0501	Belongs to the peptidase M48B family
HMSLTHF_RS05155	COG0436	Aminotransferase
HMSLTHF_RS05165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMSLTHF_RS05175	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HMSLTHF_RS05185	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HMSLTHF_RS05225	COG1131	(ABC) transporter
HMSLTHF_RS05230	COG0842	Transport permease protein
HMSLTHF_RS05235	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HMSLTHF_RS05235	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HMSLTHF_RS05240	COG0778	Nitroreductase
HMSLTHF_RS05270	COG0477	Major facilitator Superfamily
HMSLTHF_RS05275	COG0733	neurotransmitter:sodium symporter activity
HMSLTHF_RS05290	COG2267	carboxylic ester hydrolase activity
HMSLTHF_RS05300	COG2840	Smr protein MutS2
HMSLTHF_RS05310	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HMSLTHF_RS05325	COG3243	poly(R)-hydroxyalkanoic acid synthase
HMSLTHF_RS05335	COG4535	Mg2 and Co2 transporter CorC
HMSLTHF_RS05340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HMSLTHF_RS05345	COG1702	phosphate starvation-inducible protein PhoH
HMSLTHF_RS05350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HMSLTHF_RS05370	COG0640	Transcriptional regulator
HMSLTHF_RS05375	COG0793	Belongs to the peptidase S41A family
HMSLTHF_RS05380	COG1362	aminopeptidase activity
HMSLTHF_RS05390	COG0012	GTP binding
HMSLTHF_RS05395	COG0193	aminoacyl-tRNA hydrolase activity
HMSLTHF_RS05400	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HMSLTHF_RS05405	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HMSLTHF_RS05415	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HMSLTHF_RS05420	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HMSLTHF_RS05430	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HMSLTHF_RS05435	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HMSLTHF_RS05440	COG2890	protein-(glutamine-N5) methyltransferase activity
HMSLTHF_RS05450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HMSLTHF_RS05470	COG3842	ATPase activity
HMSLTHF_RS05475	COG1176	ABC-type spermidine putrescine transport system, permease component I
HMSLTHF_RS05480	COG1177	transmembrane transport
HMSLTHF_RS05495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HMSLTHF_RS05505	COG2081	HI0933 family
HMSLTHF_RS05520	COG4575	ribosome binding
HMSLTHF_RS05530	COG1196	nuclear chromosome segregation
HMSLTHF_RS05530	COG3264	Mechanosensitive ion channel
HMSLTHF_RS05535	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HMSLTHF_RS05545	COG4991	sh3 domain protein
HMSLTHF_RS05550	COG0500	methyltransferase
HMSLTHF_RS05560	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HMSLTHF_RS05565	COG4208	sulfate ABC transporter
HMSLTHF_RS05580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HMSLTHF_RS05585	COG1252	NADH dehydrogenase
HMSLTHF_RS05590	COG0546	phosphoglycolate phosphatase activity
HMSLTHF_RS05595	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMSLTHF_RS05605	COG3383	formate dehydrogenase (NAD+) activity
HMSLTHF_RS05610	COG0512	Glutamine amidotransferase of anthranilate synthase
HMSLTHF_RS05615	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HMSLTHF_RS05620	COG0134	indole-3-glycerol-phosphate synthase activity
HMSLTHF_RS05625	COG0277	FAD linked oxidase domain protein
HMSLTHF_RS05625	COG0247	lactate metabolic process
HMSLTHF_RS05640	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HMSLTHF_RS05665	COG3850	Histidine kinase
HMSLTHF_RS05665	COG5002	protein histidine kinase activity
HMSLTHF_RS05705	COG0628	permease
HMSLTHF_RS05720	COG0175	sulfate reduction
HMSLTHF_RS05730	COG1802	Transcriptional regulator
HMSLTHF_RS05735	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HMSLTHF_RS05740	COG0372	Belongs to the citrate synthase family
HMSLTHF_RS05745	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HMSLTHF_RS05760	COG0284	orotidine-5'-phosphate decarboxylase activity
HMSLTHF_RS05765	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HMSLTHF_RS05775	COG0776	regulation of translation
HMSLTHF_RS05785	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HMSLTHF_RS05810	COG0322	excinuclease ABC activity
HMSLTHF_RS05835	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HMSLTHF_RS05840	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HMSLTHF_RS05845	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HMSLTHF_RS05850	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HMSLTHF_RS05855	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HMSLTHF_RS05865	COG3100	YcgL domain-containing protein
HMSLTHF_RS05870	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HMSLTHF_RS05875	COG2983	Belongs to the UPF0260 family
HMSLTHF_RS05890	COG0121	glutamine amidotransferase
HMSLTHF_RS05895	COG0318	PFAM AMP-dependent synthetase and ligase
HMSLTHF_RS05900	COG1643	Atp-dependent helicase
HMSLTHF_RS05910	COG2853	Lipoprotein
HMSLTHF_RS05925	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HMSLTHF_RS05930	COG2814	Major facilitator Superfamily
HMSLTHF_RS05945	COG0573	inorganic phosphate transmembrane transporter activity
HMSLTHF_RS05955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HMSLTHF_RS05960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HMSLTHF_RS05980	COG0431	NADPH-dependent FMN reductase
HMSLTHF_RS05985	COG0798	PFAM Bile acid sodium symporter
HMSLTHF_RS05990	COG0431	NADPH-dependent FMN reductase
HMSLTHF_RS06000	COG0840	transmembrane signaling receptor activity
HMSLTHF_RS06005	COG0183	Belongs to the thiolase family
HMSLTHF_RS06010	COG1309	transcriptional regulator
HMSLTHF_RS06015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HMSLTHF_RS06025	COG1960	acyl-CoA dehydrogenase activity
HMSLTHF_RS06045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HMSLTHF_RS06050	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HMSLTHF_RS06060	COG0425	Belongs to the sulfur carrier protein TusA family
HMSLTHF_RS06075	COG3101	peptidyl-lysine hydroxylation
HMSLTHF_RS06085	COG0084	hydrolase, TatD family'
HMSLTHF_RS06100	COG1960	acyl-CoA dehydrogenase activity
HMSLTHF_RS06105	COG0183	Belongs to the thiolase family
HMSLTHF_RS06110	COG0318	PFAM AMP-dependent synthetase and ligase
HMSLTHF_RS06125	COG0589	response to stress
HMSLTHF_RS06150	COG0183	Belongs to the thiolase family
HMSLTHF_RS06165	COG1881	PFAM PEBP family protein
HMSLTHF_RS06170	COG2824	Alkylphosphonate utilization operon protein PhnA
HMSLTHF_RS06180	COG0719	Fe-S assembly protein
HMSLTHF_RS06185	COG0396	ATPase activity
HMSLTHF_RS06190	COG0719	Fe-S assembly protein
HMSLTHF_RS06195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HMSLTHF_RS06205	COG2949	membrane
HMSLTHF_RS06215	COG0189	ligase activity
HMSLTHF_RS06230	COG3098	single-species biofilm formation
HMSLTHF_RS06235	COG3047	cAMP biosynthetic process
HMSLTHF_RS06240	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HMSLTHF_RS06260	COG0617	tRNA 3'-terminal CCA addition
HMSLTHF_RS06260	COG0517	IMP dehydrogenase activity
HMSLTHF_RS06260	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HMSLTHF_RS06275	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HMSLTHF_RS06315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HMSLTHF_RS06325	COG2217	Heavy metal translocating P-type atpase
HMSLTHF_RS06365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HMSLTHF_RS06380	COG0166	Belongs to the GPI family
HMSLTHF_RS06385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMSLTHF_RS06385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HMSLTHF_RS06385	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HMSLTHF_RS06390	COG1105	Belongs to the carbohydrate kinase PfkB family
HMSLTHF_RS06395	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMSLTHF_RS06395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HMSLTHF_RS06405	COG1803	Methylglyoxal synthase
HMSLTHF_RS06410	COG0469	pyruvate kinase activity
HMSLTHF_RS06420	COG1609	Transcriptional regulator
HMSLTHF_RS06430	COG0366	Alpha amylase catalytic
HMSLTHF_RS06445	COG1653	transport
HMSLTHF_RS06455	COG2909	trisaccharide binding
HMSLTHF_RS06460	COG0366	Alpha amylase catalytic
HMSLTHF_RS06470	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HMSLTHF_RS06475	COG3833	ABC-type maltose transport systems, permease component
HMSLTHF_RS06480	COG1175	transmembrane transport
HMSLTHF_RS06485	COG2182	Extracellular solute-binding protein
HMSLTHF_RS06505	COG1621	beta-fructofuranosidase activity
HMSLTHF_RS06510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HMSLTHF_RS06520	COG0837	glucose binding
HMSLTHF_RS06545	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HMSLTHF_RS06550	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HMSLTHF_RS06555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HMSLTHF_RS06565	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HMSLTHF_RS06570	COG0406	alpha-ribazole phosphatase activity
HMSLTHF_RS06580	COG4206	TonB-dependent receptor
HMSLTHF_RS06585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HMSLTHF_RS06590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMSLTHF_RS06595	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HMSLTHF_RS06620	COG4974	Belongs to the 'phage' integrase family
HMSLTHF_RS06680	COG0517	IMP dehydrogenase activity
HMSLTHF_RS06740	COG2226	methyltransferase
HMSLTHF_RS06760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HMSLTHF_RS06765	COG2066	Belongs to the glutaminase family
HMSLTHF_RS06775	COG1492	cobalamin metabolic process
HMSLTHF_RS06795	COG1929	Belongs to the glycerate kinase type-1 family
HMSLTHF_RS06820	COG0542	response to heat
HMSLTHF_RS06825	COG3284	Transcriptional regulator
HMSLTHF_RS06835	COG1063	alcohol dehydrogenase
HMSLTHF_RS06850	COG0006	proline dipeptidase activity
HMSLTHF_RS06855	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS06860	COG4608	Belongs to the ABC transporter superfamily
HMSLTHF_RS06870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMSLTHF_RS06875	COG0601	transmembrane transport
HMSLTHF_RS06895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HMSLTHF_RS06905	COG1280	lysine exporter protein (LysE YggA)
HMSLTHF_RS06910	COG0586	Pfam SNARE associated Golgi protein
HMSLTHF_RS06925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HMSLTHF_RS06930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HMSLTHF_RS06940	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HMSLTHF_RS06945	COG0768	penicillin binding
HMSLTHF_RS06950	COG0772	Belongs to the SEDS family
HMSLTHF_RS06955	COG2951	lytic endotransglycosylase activity
HMSLTHF_RS06965	COG1686	Belongs to the peptidase S11 family
HMSLTHF_RS06970	COG2921	Belongs to the UPF0250 family
HMSLTHF_RS06975	COG0321	lipoyl(octanoyl) transferase activity
HMSLTHF_RS06980	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HMSLTHF_RS06985	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS07020	COG3344	reverse transcriptase
HMSLTHF_RS07025	COG1376	ErfK ybiS ycfS ynhG family protein
HMSLTHF_RS07030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HMSLTHF_RS07040	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HMSLTHF_RS07045	COG1805	sodium ion transport
HMSLTHF_RS07060	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HMSLTHF_RS07075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMSLTHF_RS07100	COG0495	leucyl-tRNA aminoacylation
HMSLTHF_RS07115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HMSLTHF_RS07120	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HMSLTHF_RS07125	COG0653	protein targeting
HMSLTHF_RS07130	COG2211	Major facilitator Superfamily
HMSLTHF_RS07135	COG1047	Peptidyl-prolyl cis-trans
HMSLTHF_RS07150	COG0741	lytic transglycosylase activity
HMSLTHF_RS07155	COG0442	prolyl-tRNA aminoacylation
HMSLTHF_RS07170	COG1396	sequence-specific DNA binding
HMSLTHF_RS07180	COG0584	glycerophosphoryl diester phosphodiesterase
HMSLTHF_RS07190	COG1737	Transcriptional regulator
HMSLTHF_RS07195	COG1024	Enoyl-CoA hydratase
HMSLTHF_RS07205	COG1024	Enoyl-CoA hydratase
HMSLTHF_RS07210	COG3273	potassium ion transport
HMSLTHF_RS07210	COG0471	metal ion transport
HMSLTHF_RS07215	COG1349	DNA-binding transcription factor activity
HMSLTHF_RS07220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HMSLTHF_RS07230	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HMSLTHF_RS07245	COG0395	ABC-type sugar transport system, permease component
HMSLTHF_RS07255	COG3842	ATPase activity
HMSLTHF_RS07300	COG1321	iron dependent repressor
HMSLTHF_RS07310	COG1121	(ABC) transporter
HMSLTHF_RS07315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMSLTHF_RS07345	COG2610	gluconate transmembrane transporter activity
HMSLTHF_RS07350	COG2056	Na+-H+ antiporter family
HMSLTHF_RS07360	COG0459	protein refolding
HMSLTHF_RS07365	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HMSLTHF_RS07375	COG1028	Short-chain dehydrogenase reductase Sdr
HMSLTHF_RS07405	COG0302	gtp cyclohydrolase
HMSLTHF_RS07420	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HMSLTHF_RS07430	COG2264	protein methyltransferase activity
HMSLTHF_RS07440	COG0511	ligase activity, forming carbon-carbon bonds
HMSLTHF_RS07450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HMSLTHF_RS07455	COG2815	serine threonine protein kinase
HMSLTHF_RS07455	COG0515	serine threonine protein kinase
HMSLTHF_RS07460	COG0205	6-phosphofructokinase activity
HMSLTHF_RS07465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HMSLTHF_RS07470	COG0137	argininosuccinate synthase activity
HMSLTHF_RS07480	COG5002	protein histidine kinase activity
HMSLTHF_RS07490	COG5002	protein histidine kinase activity
HMSLTHF_RS07490	COG2176	DNA-directed DNA polymerase activity
HMSLTHF_RS07495	COG0745	RESPONSE REGULATOR receiver
HMSLTHF_RS07505	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HMSLTHF_RS07510	COG4660	Part of a membrane complex involved in electron transport
HMSLTHF_RS07520	COG4658	electron transport chain
HMSLTHF_RS07530	COG2878	Part of a membrane complex involved in electron transport
HMSLTHF_RS07535	COG4657	Part of a membrane complex involved in electron transport
HMSLTHF_RS07545	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMSLTHF_RS07545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMSLTHF_RS07565	COG0824	Thioesterase
HMSLTHF_RS07575	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HMSLTHF_RS07580	COG1605	Chorismate mutase
HMSLTHF_RS07580	COG0077	Prephenate dehydratase
HMSLTHF_RS07585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HMSLTHF_RS07625	COG0237	dephospho-CoA kinase activity
HMSLTHF_RS07685	COG1611	Belongs to the LOG family
HMSLTHF_RS07690	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS07700	COG0509	glycine decarboxylation via glycine cleavage system
HMSLTHF_RS07710	COG1115	amino acid carrier protein
HMSLTHF_RS07715	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HMSLTHF_RS07720	COG4942	peptidase
HMSLTHF_RS07730	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS07735	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HMSLTHF_RS07745	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HMSLTHF_RS07755	COG1028	Short-chain dehydrogenase reductase Sdr
HMSLTHF_RS07760	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HMSLTHF_RS07765	COG2205	protein histidine kinase activity
HMSLTHF_RS07775	COG0418	dihydroorotase activity
HMSLTHF_RS07780	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HMSLTHF_RS07785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HMSLTHF_RS07810	COG0004	ammonium transporteR
HMSLTHF_RS07815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HMSLTHF_RS07825	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HMSLTHF_RS07830	COG0084	hydrolase, TatD family'
HMSLTHF_RS07835	COG0354	folic acid binding
HMSLTHF_RS07850	COG0556	nucleotide-excision repair
HMSLTHF_RS07860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HMSLTHF_RS07865	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS07870	COG1051	belongs to the nudix hydrolase family
HMSLTHF_RS07870	COG1056	cytidyltransferase-related domain
HMSLTHF_RS07875	COG1295	ribonuclease BN
HMSLTHF_RS07880	COG1254	Belongs to the acylphosphatase family
HMSLTHF_RS07885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HMSLTHF_RS07895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HMSLTHF_RS07900	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HMSLTHF_RS07905	COG0632	four-way junction helicase activity
HMSLTHF_RS07910	COG2255	four-way junction helicase activity
HMSLTHF_RS07915	COG0824	Thioesterase
HMSLTHF_RS07935	COG0823	Involved in the tonB-independent uptake of proteins
HMSLTHF_RS07940	COG2885	chlorophyll binding
HMSLTHF_RS07950	COG1028	Short-chain dehydrogenase reductase Sdr
HMSLTHF_RS07985	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMSLTHF_RS07995	COG0288	reversible hydration of carbon dioxide
HMSLTHF_RS08005	COG0456	acetyltransferase
HMSLTHF_RS08010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HMSLTHF_RS08015	COG1917	Cupin 2, conserved barrel domain protein
HMSLTHF_RS08025	COG0189	ligase activity
HMSLTHF_RS08025	COG4067	protein conserved in archaea
HMSLTHF_RS08040	COG0735	belongs to the Fur family
HMSLTHF_RS08045	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HMSLTHF_RS08050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HMSLTHF_RS08055	COG2166	iron-sulfur cluster assembly
HMSLTHF_RS08070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HMSLTHF_RS08075	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HMSLTHF_RS08075	COG0316	Belongs to the HesB IscA family
HMSLTHF_RS08085	COG0534	Mate efflux family protein
HMSLTHF_RS08090	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HMSLTHF_RS08100	COG2840	Smr protein MutS2
HMSLTHF_RS08125	COG0259	pyridoxamine-phosphate oxidase activity
HMSLTHF_RS08135	COG0123	including yeast histone deacetylase and acetoin utilization protein
HMSLTHF_RS08145	COG2920	part of a sulfur-relay system
HMSLTHF_RS08155	COG2923	Belongs to the DsrF TusC family
HMSLTHF_RS08175	COG3002	Belongs to the UPF0753 family
HMSLTHF_RS08180	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HMSLTHF_RS08385	COG1484	DNA-dependent DNA replication
HMSLTHF_RS08460	COG0629	single-stranded DNA binding
HMSLTHF_RS08510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HMSLTHF_RS08515	COG0596	Alpha beta hydrolase
HMSLTHF_RS08520	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HMSLTHF_RS08530	COG0640	Transcriptional regulator
HMSLTHF_RS08535	COG0616	signal peptide processing
HMSLTHF_RS08545	COG2816	NAD+ diphosphatase activity
HMSLTHF_RS08555	COG0328	RNA-DNA hybrid ribonuclease activity
HMSLTHF_RS08565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HMSLTHF_RS08570	COG1388	LysM domain
HMSLTHF_RS08570	COG0741	lytic transglycosylase activity
HMSLTHF_RS08575	COG4166	transmembrane transport
HMSLTHF_RS08580	COG4174	ABC transporter (Permease)
HMSLTHF_RS08585	COG4239	(ABC) transporter, permease
HMSLTHF_RS08590	COG4172	Belongs to the ABC transporter superfamily
HMSLTHF_RS08595	COG1187	pseudouridine synthase activity
HMSLTHF_RS08605	COG2962	Rard protein
HMSLTHF_RS08615	COG0659	secondary active sulfate transmembrane transporter activity
HMSLTHF_RS08635	COG1024	Enoyl-CoA hydratase
HMSLTHF_RS08640	COG1960	acyl-CoA dehydrogenase activity
HMSLTHF_RS08645	COG1960	acyl-CoA dehydrogenase activity
HMSLTHF_RS08650	COG1024	Enoyl-CoA hydratase
HMSLTHF_RS08655	COG2070	2-Nitropropane dioxygenase
HMSLTHF_RS08680	COG0318	PFAM AMP-dependent synthetase and ligase
HMSLTHF_RS08685	COG1960	acyl-CoA dehydrogenase activity
HMSLTHF_RS08690	COG1250	3-hydroxyacyl-CoA dehydrogenase
HMSLTHF_RS08695	COG0183	Belongs to the thiolase family
HMSLTHF_RS08700	COG1414	Transcriptional regulator
HMSLTHF_RS08705	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HMSLTHF_RS08725	COG0515	serine threonine protein kinase
HMSLTHF_RS08735	COG0022	dehydrogenase e1 component
HMSLTHF_RS08745	COG1174	glycine betaine transport
HMSLTHF_RS08750	COG1125	glycine betaine transport
HMSLTHF_RS08755	COG1174	glycine betaine transport
HMSLTHF_RS08765	COG0215	cysteine-tRNA ligase activity
HMSLTHF_RS08770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HMSLTHF_RS08775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HMSLTHF_RS08780	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HMSLTHF_RS08785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HMSLTHF_RS08795	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HMSLTHF_RS08800	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HMSLTHF_RS08805	COG0740	serine-type endopeptidase activity
HMSLTHF_RS08810	COG0544	peptidyl-prolyl cis-trans isomerase activity
HMSLTHF_RS08830	COG0776	regulation of translation
HMSLTHF_RS08835	COG0072	phenylalanine-tRNA ligase activity
HMSLTHF_RS08840	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HMSLTHF_RS08845	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HMSLTHF_RS08850	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HMSLTHF_RS08860	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HMSLTHF_RS08875	COG1612	heme a metabolic process
HMSLTHF_RS08900	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HMSLTHF_RS08905	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HMSLTHF_RS08910	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HMSLTHF_RS08930	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HMSLTHF_RS08935	COG1643	Atp-dependent helicase
HMSLTHF_RS08940	COG1309	transcriptional regulator
HMSLTHF_RS08950	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HMSLTHF_RS08960	COG0402	S-adenosylhomocysteine deaminase activity
HMSLTHF_RS08965	COG3344	reverse transcriptase
HMSLTHF_RS08995	COG1858	cytochrome C peroxidase
HMSLTHF_RS09000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HMSLTHF_RS09005	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HMSLTHF_RS09010	COG4988	ABC transporter
HMSLTHF_RS09015	COG1294	oxidase, subunit
HMSLTHF_RS09020	COG1271	oxidase subunit
HMSLTHF_RS09030	COG2995	paraquat-inducible protein a
HMSLTHF_RS09035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HMSLTHF_RS09035	COG3008	intermembrane lipid transfer
HMSLTHF_RS09040	COG3009	Protein conserved in bacteria
HMSLTHF_RS09045	COG0513	Belongs to the DEAD box helicase family
HMSLTHF_RS09055	COG2807	transmembrane transport
HMSLTHF_RS09060	COG0252	asparaginase activity
HMSLTHF_RS09080	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HMSLTHF_RS09085	COG0602	queuosine metabolic process
HMSLTHF_RS09115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HMSLTHF_RS09120	COG0584	glycerophosphoryl diester phosphodiesterase
HMSLTHF_RS09125	COG0405	Gamma-glutamyltransferase
HMSLTHF_RS09135	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HMSLTHF_RS09150	COG1376	ErfK ybiS ycfS ynhG family protein
HMSLTHF_RS09155	COG1309	transcriptional regulator
HMSLTHF_RS09160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HMSLTHF_RS09180	COG0314	molybdopterin synthase activity
HMSLTHF_RS09185	COG0315	cyclic pyranopterin monophosphate synthase activity
HMSLTHF_RS09190	COG1763	Mo-molybdopterin cofactor biosynthetic process
HMSLTHF_RS09200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HMSLTHF_RS09205	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HMSLTHF_RS09210	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HMSLTHF_RS09215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HMSLTHF_RS09220	COG2252	PERMEase
HMSLTHF_RS09225	COG0307	riboflavin synthase, alpha
HMSLTHF_RS09230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMSLTHF_RS09235	COG2011	ABC-type metal ion transport system permease component
HMSLTHF_RS09240	COG1464	Belongs to the NlpA lipoprotein family
HMSLTHF_RS09245	COG1956	GAF domain-containing protein
HMSLTHF_RS09280	COG0628	permease
HMSLTHF_RS09285	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HMSLTHF_RS09290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HMSLTHF_RS09295	COG0717	Belongs to the dCTP deaminase family
HMSLTHF_RS09300	COG0489	protein tyrosine kinase activity
HMSLTHF_RS09310	COG1648	precorrin-2 dehydrogenase activity
HMSLTHF_RS09310	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HMSLTHF_RS09315	COG3706	GGDEF domain
HMSLTHF_RS09320	COG2154	pterin-4-alpha-carbinolamine dehydratase
HMSLTHF_RS09335	COG0534	Mate efflux family protein
HMSLTHF_RS09340	COG2353	YceI-like domain
HMSLTHF_RS09345	COG3038	cytochrome b561
HMSLTHF_RS09375	COG0285	dihydrofolate synthase activity
HMSLTHF_RS09380	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HMSLTHF_RS09385	COG0159	tryptophan synthase activity
HMSLTHF_RS09395	COG0135	phosphoribosylanthranilate isomerase activity
HMSLTHF_RS09415	COG0473	3-isopropylmalate dehydrogenase activity
HMSLTHF_RS09420	COG0066	3-isopropylmalate dehydratase activity
HMSLTHF_RS09425	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HMSLTHF_RS09435	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HMSLTHF_RS09440	COG0625	glutathione transferase activity
HMSLTHF_RS09450	COG1250	3-hydroxyacyl-CoA dehydrogenase
HMSLTHF_RS09450	COG1024	Enoyl-CoA hydratase
HMSLTHF_RS09455	COG1960	acyl-CoA dehydrogenase activity
HMSLTHF_RS09490	COG1960	acyl-CoA dehydrogenase activity
HMSLTHF_RS09495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HMSLTHF_RS09515	COG0318	PFAM AMP-dependent synthetase and ligase
HMSLTHF_RS09520	COG2226	methyltransferase
HMSLTHF_RS09530	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HMSLTHF_RS09550	COG1187	pseudouridine synthase activity
HMSLTHF_RS09560	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HMSLTHF_RS09565	COG3956	TIGRFAM MazG family protein
HMSLTHF_RS09570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HMSLTHF_RS09575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HMSLTHF_RS09590	COG0736	holo-[acyl-carrier-protein] synthase activity
HMSLTHF_RS09600	COG1381	Involved in DNA repair and RecF pathway recombination
HMSLTHF_RS09605	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HMSLTHF_RS09610	COG0571	ribonuclease III activity
HMSLTHF_RS09620	COG0481	GTPase activity
HMSLTHF_RS09625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HMSLTHF_RS09655	COG1199	ATP-dependent helicase activity
HMSLTHF_RS09670	COG0708	Exodeoxyribonuclease III
HMSLTHF_RS09685	COG0848	biopolymer transport protein
HMSLTHF_RS09690	COG0811	peptide transport
HMSLTHF_RS09695	COG0811	peptide transport
HMSLTHF_RS09715	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMSLTHF_RS09720	COG1780	Probably involved in ribonucleotide reductase function
HMSLTHF_RS09730	COG3547	Transposase (IS116 IS110 IS902 family)
HMSLTHF_RS09735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HMSLTHF_RS09755	COG0210	DNA helicase
HMSLTHF_RS09765	COG0084	hydrolase, TatD family'
HMSLTHF_RS09780	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HMSLTHF_RS09785	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HMSLTHF_RS09790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HMSLTHF_RS09795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HMSLTHF_RS09800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMSLTHF_RS09815	COG0416	fatty acid biosynthetic process
HMSLTHF_RS09820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HMSLTHF_RS09825	COG1399	metal-binding, possibly nucleic acid-binding protein
HMSLTHF_RS09830	COG0424	maF-like protein
HMSLTHF_RS09850	COG1530	ribonuclease E activity
HMSLTHF_RS09860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HMSLTHF_RS09865	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HMSLTHF_RS09870	COG2835	tetraacyldisaccharide 4'-kinase activity
HMSLTHF_RS09875	COG1663	tetraacyldisaccharide 4'-kinase activity
HMSLTHF_RS09880	COG1132	(ABC) transporter
HMSLTHF_RS09895	COG1136	(ABC) transporter
HMSLTHF_RS09900	COG4591	ABC-type transport system involved in lipoprotein release permease component
HMSLTHF_RS09905	COG2957	Belongs to the agmatine deiminase family
HMSLTHF_RS09910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HMSLTHF_RS09915	COG0352	thiamine-phosphate diphosphorylase activity
HMSLTHF_RS09920	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HMSLTHF_RS09925	COG0653	protein targeting
HMSLTHF_RS09935	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HMSLTHF_RS09955	COG1181	Belongs to the D-alanine--D-alanine ligase family
HMSLTHF_RS09960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HMSLTHF_RS09965	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HMSLTHF_RS09970	COG0772	Belongs to the SEDS family
HMSLTHF_RS09975	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HMSLTHF_RS09980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HMSLTHF_RS09985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HMSLTHF_RS10000	COG3116	cell division
HMSLTHF_RS10005	COG0275	rRNA processing
HMSLTHF_RS10030	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HMSLTHF_RS10035	COG2823	Periplasmic or secreted lipoprotein
HMSLTHF_RS10040	COG2969	positive regulation of protein catabolic process
HMSLTHF_RS10045	COG0625	glutathione transferase activity
HMSLTHF_RS10050	COG2857	Cytochrome c1
HMSLTHF_RS10055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HMSLTHF_RS10060	COG0723	plastoquinol--plastocyanin reductase activity
HMSLTHF_RS10065	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HMSLTHF_RS10070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HMSLTHF_RS10075	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HMSLTHF_RS10080	COG3105	Protein conserved in bacteria
HMSLTHF_RS10090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HMSLTHF_RS10095	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HMSLTHF_RS10100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HMSLTHF_RS10105	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HMSLTHF_RS10110	COG5007	Belongs to the BolA IbaG family
HMSLTHF_RS10125	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HMSLTHF_RS10130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HMSLTHF_RS10135	COG1127	ABC transporter
HMSLTHF_RS10145	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HMSLTHF_RS10165	COG1137	ATPase activity
HMSLTHF_RS10170	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HMSLTHF_RS10185	COG1660	Displays ATPase and GTPase activities
HMSLTHF_RS10195	COG0312	modulator of DNA gyrase
HMSLTHF_RS10200	COG3028	Belongs to the UPF0307 family
HMSLTHF_RS10205	COG0312	modulator of DNA gyrase
HMSLTHF_RS10215	COG1530	ribonuclease E activity
HMSLTHF_RS10220	COG0424	maF-like protein
HMSLTHF_RS10225	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HMSLTHF_RS10230	COG1792	Involved in formation and maintenance of cell shape
HMSLTHF_RS10235	COG1077	Cell shape determining protein MreB Mrl
HMSLTHF_RS10240	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HMSLTHF_RS10245	COG0154	amidase activity
HMSLTHF_RS10250	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HMSLTHF_RS10255	COG2062	phosphohistidine phosphatase, SixA
HMSLTHF_RS10260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HMSLTHF_RS10265	COG0326	Molecular chaperone. Has ATPase activity
HMSLTHF_RS10285	COG0789	Transcriptional regulator
HMSLTHF_RS10300	COG0789	Transcriptional regulator
HMSLTHF_RS10320	COG3335	DDE superfamily endonuclease
HMSLTHF_RS10395	COG1278	Cold shock
HMSLTHF_RS10405	COG1597	lipid kinase activity
HMSLTHF_RS10410	COG0308	aminopeptidase N
HMSLTHF_RS10415	COG1666	GTP binding
HMSLTHF_RS10420	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HMSLTHF_RS10425	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HMSLTHF_RS10430	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HMSLTHF_RS10435	COG0330	HflC and HflK could
HMSLTHF_RS10440	COG0330	HflC and HflK could
HMSLTHF_RS10445	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HMSLTHF_RS10450	COG1923	regulation of RNA biosynthetic process
HMSLTHF_RS10455	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HMSLTHF_RS10460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HMSLTHF_RS10465	COG0860	N-Acetylmuramoyl-L-alanine amidase
HMSLTHF_RS10470	COG0802	atpase or kinase
HMSLTHF_RS10475	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HMSLTHF_RS10475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HMSLTHF_RS10485	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HMSLTHF_RS10490	COG1162	GTPase activity
HMSLTHF_RS10500	COG0688	phosphatidylethanolamine metabolic process
HMSLTHF_RS10505	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HMSLTHF_RS10510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HMSLTHF_RS10515	COG1509	lysine 2,3-aminomutase activity
HMSLTHF_RS10525	COG1196	nuclear chromosome segregation
HMSLTHF_RS10550	COG2111	Na H antiporter
HMSLTHF_RS10550	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HMSLTHF_RS10555	COG1006	Multisubunit Na H antiporter MnhC subunit
HMSLTHF_RS10560	COG0651	ATP synthesis coupled electron transport
HMSLTHF_RS10565	COG1863	multisubunit Na H antiporter MnhE subunit
HMSLTHF_RS10570	COG2212	antiporter activity
HMSLTHF_RS10575	COG1320	monovalent cation:proton antiporter activity
HMSLTHF_RS10585	COG3830	Belongs to the UPF0237 family
HMSLTHF_RS10585	COG0560	Phosphoserine phosphatase
HMSLTHF_RS10595	COG0187	DNA topoisomerase II activity
HMSLTHF_RS10600	COG0166	Belongs to the GPI family
HMSLTHF_RS10605	COG4106	trans-aconitate 2-methyltransferase activity
HMSLTHF_RS10610	COG0500	methyltransferase
HMSLTHF_RS10615	COG2738	Putative neutral zinc metallopeptidase
HMSLTHF_RS10625	COG0693	protein deglycase activity
HMSLTHF_RS10630	COG1910	domain protein
HMSLTHF_RS10650	COG2895	sulfate adenylyltransferase (ATP) activity
HMSLTHF_RS10655	COG0175	sulfate reduction
HMSLTHF_RS10660	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HMSLTHF_RS10665	COG3151	Protein conserved in bacteria
HMSLTHF_RS10670	COG0494	nUDIX hydrolase
HMSLTHF_RS10685	COG2813	Specifically methylates the guanine in position
HMSLTHF_RS10690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HMSLTHF_RS10695	COG3706	GGDEF domain
HMSLTHF_RS10725	COG3706	GGDEF domain
HMSLTHF_RS10740	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HMSLTHF_RS10745	COG0033	Phosphoglucomutase
HMSLTHF_RS10755	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HMSLTHF_RS10765	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HMSLTHF_RS10770	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HMSLTHF_RS10775	COG0730	response to heat
HMSLTHF_RS10805	COG0039	L-malate dehydrogenase activity
HMSLTHF_RS10825	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HMSLTHF_RS10830	COG2918	glutathione biosynthetic process
HMSLTHF_RS10835	COG2183	response to ionizing radiation
HMSLTHF_RS10850	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HMSLTHF_RS10855	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HMSLTHF_RS10860	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HMSLTHF_RS10865	COG1011	Hydrolase
HMSLTHF_RS10870	COG0494	nUDIX hydrolase
HMSLTHF_RS10875	COG0673	inositol 2-dehydrogenase activity
HMSLTHF_RS10880	COG0129	dihydroxy-acid dehydratase activity
HMSLTHF_RS10885	COG0840	transmembrane signaling receptor activity
HMSLTHF_RS10885	COG0840	transmembrane signaling receptor activity
HMSLTHF_RS10890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HMSLTHF_RS10900	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HMSLTHF_RS10910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HMSLTHF_RS10915	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HMSLTHF_RS10925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HMSLTHF_RS10925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HMSLTHF_RS10930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HMSLTHF_RS10935	COG0366	Alpha amylase catalytic
HMSLTHF_RS10940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HMSLTHF_RS10970	COG3547	Transposase (IS116 IS110 IS902 family)
HMSLTHF_RS10980	COG3547	Transposase (IS116 IS110 IS902 family)
HMSLTHF_RS10995	COG2391	methyltransferase activity
HMSLTHF_RS11015	COG0840	transmembrane signaling receptor activity
HMSLTHF_RS11025	COG1215	transferase activity, transferring glycosyl groups
HMSLTHF_RS11035	COG2885	chlorophyll binding
HMSLTHF_RS11055	COG3307	-O-antigen
HMSLTHF_RS11060	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HMSLTHF_RS11075	COG4680	protein conserved in bacteria
HMSLTHF_RS11080	COG5499	transcription regulator containing HTH domain
HMSLTHF_RS11110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HMSLTHF_RS11125	COG0438	transferase activity, transferring glycosyl groups
HMSLTHF_RS11130	COG0297	glycogen (starch) synthase activity
HMSLTHF_RS11150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HMSLTHF_RS11165	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HMSLTHF_RS11170	COG3547	Transposase (IS116 IS110 IS902 family)
HMSLTHF_RS11175	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HMSLTHF_RS11180	COG4181	ATPase activity
HMSLTHF_RS11190	COG3657	addiction module killer protein
HMSLTHF_RS11195	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HMSLTHF_RS11215	COG1366	Belongs to the anti-sigma-factor antagonist family
HMSLTHF_RS11225	COG0488	(ABC) transporter
HMSLTHF_RS11230	COG0537	adenosine 5'-monophosphoramidase activity
HMSLTHF_RS11235	COG3954	Phosphoribulokinase
HMSLTHF_RS11245	COG0151	Belongs to the GarS family
HMSLTHF_RS11250	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HMSLTHF_RS11265	COG4067	protein conserved in archaea
HMSLTHF_RS11265	COG0189	ligase activity
HMSLTHF_RS11270	COG2951	lytic endotransglycosylase activity
HMSLTHF_RS11275	COG1320	monovalent cation:proton antiporter activity
HMSLTHF_RS11280	COG2212	antiporter activity
HMSLTHF_RS11335	COG0305	Participates in initiation and elongation during chromosome replication
HMSLTHF_RS11335	COG1372	Participates in initiation and elongation during chromosome replication
HMSLTHF_RS11340	COG0359	binds to the 23S rRNA
HMSLTHF_RS11350	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HMSLTHF_RS11355	COG0360	Binds together with S18 to 16S ribosomal RNA
HMSLTHF_RS11360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HMSLTHF_RS11365	COG0557	exoribonuclease II activity
HMSLTHF_RS11400	COG2719	SpoVR family
HMSLTHF_RS11405	COG2718	Belongs to the UPF0229 family
HMSLTHF_RS11410	COG2766	serine protein kinase
HMSLTHF_RS11420	COG0446	pyridine nucleotide-disulphide oxidoreductase
HMSLTHF_RS11420	COG1902	pentaerythritol trinitrate reductase activity
HMSLTHF_RS11425	COG0697	spore germination
HMSLTHF_RS11430	COG3153	acetyltransferase
HMSLTHF_RS11430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HMSLTHF_RS11445	COG1115	amino acid carrier protein
HMSLTHF_RS11485	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS11490	COG0473	3-isopropylmalate dehydrogenase activity
HMSLTHF_RS11500	COG0655	NAD(P)H dehydrogenase (quinone) activity
HMSLTHF_RS11520	COG4160	amino acid transport
HMSLTHF_RS11525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMSLTHF_RS11540	COG3447	MASE1 domain protein
HMSLTHF_RS11540	COG5002	protein histidine kinase activity
HMSLTHF_RS11540	COG5001	Diguanylate cyclase
HMSLTHF_RS11550	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HMSLTHF_RS11580	COG0129	dihydroxy-acid dehydratase activity
HMSLTHF_RS11590	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
HMSLTHF_RS11595	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HMSLTHF_RS11600	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HMSLTHF_RS11605	COG1074	ATP-dependent DNA helicase activity
HMSLTHF_RS11610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HMSLTHF_RS11650	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS11655	COG4221	oxidoreductase activity
HMSLTHF_RS11660	COG0604	alcohol dehydrogenase
HMSLTHF_RS11660	COG4221	oxidoreductase activity
HMSLTHF_RS11660	COG3321	synthase
HMSLTHF_RS11660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HMSLTHF_RS11695	COG0159	tryptophan synthase activity
HMSLTHF_RS11700	COG0133	tryptophan synthase activity
HMSLTHF_RS11720	COG2133	pyrroloquinoline quinone binding
HMSLTHF_RS11725	COG0584	glycerophosphoryl diester phosphodiesterase
HMSLTHF_RS11740	COG5002	protein histidine kinase activity
HMSLTHF_RS11740	COG5001	Diguanylate cyclase
HMSLTHF_RS11760	COG2116	formate transmembrane transporter activity
HMSLTHF_RS11765	COG4106	trans-aconitate 2-methyltransferase activity
HMSLTHF_RS11775	COG1064	alcohol dehydrogenase
HMSLTHF_RS11780	COG2207	Transcriptional regulator
HMSLTHF_RS11795	COG0579	oxidoreductase
HMSLTHF_RS11800	COG3530	Putative quorum-sensing-regulated virulence factor
HMSLTHF_RS11820	COG0693	protein deglycase activity
HMSLTHF_RS11840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HMSLTHF_RS11855	COG3938	Belongs to the proline racemase family
HMSLTHF_RS11860	COG1063	alcohol dehydrogenase
HMSLTHF_RS11870	COG0598	Magnesium transport protein CorA
HMSLTHF_RS11910	COG2308	Evidence 4 Homologs of previously reported genes of
HMSLTHF_RS11925	COG1305	Transglutaminase-like
HMSLTHF_RS11930	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HMSLTHF_RS11940	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HMSLTHF_RS11995	COG3724	N-succinylarginine dihydrolase activity
HMSLTHF_RS12000	COG1012	belongs to the aldehyde dehydrogenase family
HMSLTHF_RS12030	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HMSLTHF_RS12040	COG0386	Belongs to the glutathione peroxidase family
HMSLTHF_RS12050	COG0217	transcriptional regulatory protein
HMSLTHF_RS12070	COG0604	alcohol dehydrogenase
HMSLTHF_RS12075	COG1132	(ABC) transporter
HMSLTHF_RS12090	COG0513	Belongs to the DEAD box helicase family
HMSLTHF_RS12115	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HMSLTHF_RS12120	COG1653	transport
HMSLTHF_RS12125	COG0395	ABC-type sugar transport system, permease component
HMSLTHF_RS12130	COG1175	transmembrane transport
HMSLTHF_RS12145	COG3842	ATPase activity
HMSLTHF_RS12160	COG4372	Transposase
HMSLTHF_RS12175	COG1609	Transcriptional regulator
HMSLTHF_RS12190	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS12195	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HMSLTHF_RS12200	COG1295	ribonuclease BN
HMSLTHF_RS12205	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HMSLTHF_RS12205	COG2111	Na H antiporter
HMSLTHF_RS12210	COG0651	ATP synthesis coupled electron transport
HMSLTHF_RS12215	COG0651	ATP synthesis coupled electron transport
HMSLTHF_RS12230	COG3273	potassium ion transport
HMSLTHF_RS12230	COG0471	metal ion transport
HMSLTHF_RS12235	COG3344	reverse transcriptase
HMSLTHF_RS12240	COG1278	Cold shock
HMSLTHF_RS12255	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS12265	COG1012	belongs to the aldehyde dehydrogenase family
HMSLTHF_RS12275	COG0659	secondary active sulfate transmembrane transporter activity
HMSLTHF_RS12280	COG1454	alcohol dehydrogenase
HMSLTHF_RS12285	COG1012	belongs to the aldehyde dehydrogenase family
HMSLTHF_RS12290	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HMSLTHF_RS12300	COG0419	ATPase involved in DNA repair
HMSLTHF_RS12305	COG0420	3'-5' exonuclease activity
HMSLTHF_RS12310	COG0471	metal ion transport
HMSLTHF_RS12320	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HMSLTHF_RS12345	COG4774	siderophore transport
HMSLTHF_RS12350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HMSLTHF_RS12355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HMSLTHF_RS12360	COG3706	GGDEF domain
HMSLTHF_RS12365	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HMSLTHF_RS12390	COG1404	Belongs to the peptidase S8 family
HMSLTHF_RS12395	COG0464	growth
HMSLTHF_RS12420	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HMSLTHF_RS12440	COG0732	type I restriction modification DNA specificity domain
HMSLTHF_RS12445	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HMSLTHF_RS12465	COG5314	conjugation
HMSLTHF_RS12515	COG1132	(ABC) transporter
HMSLTHF_RS12520	COG1120	ATPase activity
HMSLTHF_RS12525	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMSLTHF_RS12530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMSLTHF_RS12540	COG4771	TonB-dependent receptor
HMSLTHF_RS12550	COG4771	TonB-dependent receptor
HMSLTHF_RS12555	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS12565	COG2133	pyrroloquinoline quinone binding
HMSLTHF_RS12590	COG4175	Glycine betaine
HMSLTHF_RS12590	COG0517	IMP dehydrogenase activity
HMSLTHF_RS12595	COG4176	ABC-type proline glycine betaine transport system permease component
HMSLTHF_RS12605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HMSLTHF_RS12640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMSLTHF_RS12650	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HMSLTHF_RS12660	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS12665	COG1760	l-serine dehydratase
HMSLTHF_RS12685	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HMSLTHF_RS12700	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HMSLTHF_RS12705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HMSLTHF_RS12710	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HMSLTHF_RS12730	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HMSLTHF_RS12735	COG2967	ApaG domain
HMSLTHF_RS12740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HMSLTHF_RS12745	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HMSLTHF_RS12750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HMSLTHF_RS12755	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HMSLTHF_RS12760	COG3178	'Phosphotransferase
HMSLTHF_RS12765	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HMSLTHF_RS12770	COG1765	OsmC-like protein
HMSLTHF_RS12775	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HMSLTHF_RS12780	COG1560	Kdo2-lipid A biosynthetic process
HMSLTHF_RS12785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HMSLTHF_RS12795	COG1388	LysM domain
HMSLTHF_RS12795	COG4942	peptidase
HMSLTHF_RS12805	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HMSLTHF_RS12810	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HMSLTHF_RS12815	COG0585	pseudouridine synthase activity
HMSLTHF_RS12820	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HMSLTHF_RS12825	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HMSLTHF_RS12830	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HMSLTHF_RS12850	COG5001	Diguanylate cyclase
HMSLTHF_RS12850	COG4251	negative regulation of phosphorylation
HMSLTHF_RS12850	COG3706	GGDEF domain
HMSLTHF_RS12850	COG2203	Gaf domain
HMSLTHF_RS12855	COG1737	Transcriptional regulator
HMSLTHF_RS12870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HMSLTHF_RS12875	COG0589	response to stress
HMSLTHF_RS12880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HMSLTHF_RS12890	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HMSLTHF_RS12895	COG0589	response to stress
HMSLTHF_RS12900	COG0659	secondary active sulfate transmembrane transporter activity
HMSLTHF_RS12905	COG0473	3-isopropylmalate dehydrogenase activity
HMSLTHF_RS12920	COG0450	alkyl hydroperoxide reductase
HMSLTHF_RS12925	COG1253	flavin adenine dinucleotide binding
HMSLTHF_RS12945	COG1854	S-ribosylhomocysteine lyase activity
HMSLTHF_RS12960	COG3344	reverse transcriptase
HMSLTHF_RS12965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HMSLTHF_RS12970	COG1012	belongs to the aldehyde dehydrogenase family
HMSLTHF_RS12975	COG1522	sequence-specific DNA binding
HMSLTHF_RS12980	COG3608	succinylglutamate desuccinylase aspartoacylase
HMSLTHF_RS12985	COG0006	proline dipeptidase activity
HMSLTHF_RS12990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HMSLTHF_RS13000	COG2431	L-lysine efflux transmembrane transporter activity
HMSLTHF_RS13005	COG0700	Nucleoside recognition
HMSLTHF_RS13010	COG1944	ATP diphosphatase activity
HMSLTHF_RS13020	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS13035	COG1309	transcriptional regulator
HMSLTHF_RS13050	COG2205	protein histidine kinase activity
HMSLTHF_RS13055	COG0745	RESPONSE REGULATOR receiver
HMSLTHF_RS13065	COG0789	Transcriptional regulator
HMSLTHF_RS13105	COG0789	Transcriptional regulator
HMSLTHF_RS13145	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HMSLTHF_RS13165	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HMSLTHF_RS13175	COG1012	belongs to the aldehyde dehydrogenase family
HMSLTHF_RS13235	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HMSLTHF_RS13255	COG3842	ATPase activity
HMSLTHF_RS13270	COG0469	pyruvate kinase activity
HMSLTHF_RS13275	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HMSLTHF_RS13280	COG3257	ureidoglycine aminohydrolase activity
HMSLTHF_RS13300	COG1953	Uracil, thiamine, allantoin
HMSLTHF_RS13315	COG2351	hydroxyisourate hydrolase activity
HMSLTHF_RS13320	COG3648	Uricase
HMSLTHF_RS13320	COG3195	allantoin biosynthetic process
HMSLTHF_RS13340	COG0625	glutathione transferase activity
HMSLTHF_RS13350	COG1620	l-lactate permease
HMSLTHF_RS13355	COG0277	FAD linked oxidase domain protein
HMSLTHF_RS13360	COG0277	FAD linked oxidase domain protein
HMSLTHF_RS13365	COG0247	lactate metabolic process
HMSLTHF_RS13370	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HMSLTHF_RS13405	COG3278	Belongs to the heme-copper respiratory oxidase family
HMSLTHF_RS13420	COG2010	Cytochrome c
HMSLTHF_RS13425	COG0348	domain, Protein
HMSLTHF_RS13435	COG2217	Heavy metal translocating P-type atpase
HMSLTHF_RS13455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HMSLTHF_RS13460	COG0037	tRNA processing
HMSLTHF_RS13480	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HMSLTHF_RS13490	COG2205	protein histidine kinase activity
HMSLTHF_RS13490	COG0784	Response regulator, receiver
HMSLTHF_RS13490	COG2198	Histidine kinase
HMSLTHF_RS13500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HMSLTHF_RS13520	COG0742	ribosomal rna small subunit methyltransferase
HMSLTHF_RS13525	COG1214	PFAM Peptidase M22, glycoprotease
HMSLTHF_RS13530	COG0563	adenylate kinase activity
HMSLTHF_RS13545	COG3023	N-Acetylmuramoyl-L-alanine amidase
HMSLTHF_RS13560	COG1720	tRNA m6t6A37 methyltransferase activity
HMSLTHF_RS13565	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HMSLTHF_RS13575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HMSLTHF_RS13580	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HMSLTHF_RS13590	COG0425	Belongs to the sulfur carrier protein TusA family
HMSLTHF_RS13600	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HMSLTHF_RS13615	COG1187	pseudouridine synthase activity
HMSLTHF_RS13620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HMSLTHF_RS13625	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HMSLTHF_RS13630	COG1061	Type III restriction enzyme res subunit
HMSLTHF_RS13635	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMSLTHF_RS13635	COG0047	phosphoribosylformylglycinamidine synthase activity
HMSLTHF_RS13640	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HMSLTHF_RS13645	COG0590	tRNA wobble adenosine to inosine editing
HMSLTHF_RS13650	COG1946	Acyl-CoA thioesterase
HMSLTHF_RS13655	COG0281	malic enzyme
HMSLTHF_RS13660	COG0254	rRNA binding
HMSLTHF_RS13665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HMSLTHF_RS13670	COG0018	arginyl-trna synthetase
HMSLTHF_RS13685	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HMSLTHF_RS13695	COG2226	methyltransferase
HMSLTHF_RS13705	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HMSLTHF_RS13710	COG0140	phosphoribosyl-ATP diphosphatase activity
HMSLTHF_RS13715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HMSLTHF_RS13720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HMSLTHF_RS13730	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HMSLTHF_RS13745	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HMSLTHF_RS13750	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS13755	COG2205	protein histidine kinase activity
HMSLTHF_RS13760	COG0745	RESPONSE REGULATOR receiver
HMSLTHF_RS13775	COG3577	Aspartyl protease
HMSLTHF_RS13815	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HMSLTHF_RS13820	COG2027	D-alanyl-D-alanine carboxypeptidase
HMSLTHF_RS13840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HMSLTHF_RS13845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HMSLTHF_RS13850	COG0534	Mate efflux family protein
HMSLTHF_RS13855	COG2031	fatty acid transporter
HMSLTHF_RS13860	COG1607	acyl-coa hydrolase
HMSLTHF_RS13915	COG1929	Belongs to the glycerate kinase type-1 family
HMSLTHF_RS13920	COG0783	Belongs to the Dps family
HMSLTHF_RS13925	COG2195	Cleaves the N-terminal amino acid of tripeptides
HMSLTHF_RS13930	COG1444	tRNA N-acetyltransferase activity
HMSLTHF_RS13935	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HMSLTHF_RS13950	COG1178	ABC-type Fe3 transport system permease component
HMSLTHF_RS13955	COG3842	ATPase activity
HMSLTHF_RS13960	COG1840	ABC-type Fe3 transport system, periplasmic component
HMSLTHF_RS13975	COG1166	arginine decarboxylase activity
HMSLTHF_RS13980	COG0179	Fumarylacetoacetate (FAA) hydrolase
HMSLTHF_RS13985	COG5285	phytanoyl-CoA dioxygenase
HMSLTHF_RS13995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HMSLTHF_RS14000	COG0071	Belongs to the small heat shock protein (HSP20) family
HMSLTHF_RS14100	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HMSLTHF_RS14105	COG1194	a g-specific adenine glycosylase
HMSLTHF_RS14120	COG0131	Imidazoleglycerol-phosphate dehydratase
HMSLTHF_RS14125	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HMSLTHF_RS14130	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HMSLTHF_RS14135	COG0107	imidazoleglycerol-phosphate synthase activity
HMSLTHF_RS14145	COG3068	Protein conserved in bacteria
HMSLTHF_RS14155	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HMSLTHF_RS14160	COG0709	Synthesizes selenophosphate from selenide and ATP
HMSLTHF_RS14165	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HMSLTHF_RS14175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HMSLTHF_RS14205	COG1183	phosphatidylcholine synthase activity
HMSLTHF_RS14210	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HMSLTHF_RS14220	COG0440	acetolactate synthase activity
HMSLTHF_RS14225	COG0028	Belongs to the TPP enzyme family
HMSLTHF_RS14240	COG0564	pseudouridine synthase activity
HMSLTHF_RS14250	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HMSLTHF_RS14250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HMSLTHF_RS14270	COG0492	ferredoxin-NADP+ reductase activity
HMSLTHF_RS14305	COG2391	methyltransferase activity
HMSLTHF_RS14310	COG0180	Tryptophanyl-tRNA synthetase
HMSLTHF_RS14335	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HMSLTHF_RS14340	COG1047	Peptidyl-prolyl cis-trans
HMSLTHF_RS14350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HMSLTHF_RS14355	COG0196	riboflavin kinase activity
HMSLTHF_RS14365	COG0268	Binds directly to 16S ribosomal RNA
HMSLTHF_RS14375	COG3311	Transcriptional regulator
HMSLTHF_RS14455	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HMSLTHF_RS14485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HMSLTHF_RS14490	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HMSLTHF_RS14495	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HMSLTHF_RS14510	COG3932	Exopolysaccharide synthesis, ExoD
HMSLTHF_RS14520	COG0842	Transport permease protein
HMSLTHF_RS14525	COG1131	(ABC) transporter
HMSLTHF_RS14535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HMSLTHF_RS14550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HMSLTHF_RS14560	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HMSLTHF_RS14570	COG4221	oxidoreductase activity
HMSLTHF_RS14575	COG1012	belongs to the aldehyde dehydrogenase family
HMSLTHF_RS14580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HMSLTHF_RS14585	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HMSLTHF_RS14605	COG3829	transcription factor binding
HMSLTHF_RS14605	COG3290	protein histidine kinase activity
HMSLTHF_RS14625	COG5654	RES domain protein
HMSLTHF_RS14640	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HMSLTHF_RS14645	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HMSLTHF_RS14650	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HMSLTHF_RS14655	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HMSLTHF_RS14660	COG3766	membrane
HMSLTHF_RS14670	COG0754	glutathionylspermidine amidase activity
HMSLTHF_RS14680	COG0521	Mo-molybdopterin cofactor biosynthetic process
HMSLTHF_RS14695	COG0437	4 iron, 4 sulfur cluster binding
HMSLTHF_RS14700	COG3383	formate dehydrogenase (NAD+) activity
HMSLTHF_RS14730	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HMSLTHF_RS14735	COG0746	molybdenum cofactor guanylyltransferase activity
HMSLTHF_RS14745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HMSLTHF_RS14750	COG0523	cobalamin synthesis protein
HMSLTHF_RS14765	COG1953	Uracil, thiamine, allantoin
HMSLTHF_RS14790	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS14805	COG1250	3-hydroxyacyl-CoA dehydrogenase
HMSLTHF_RS14810	COG3246	L-lysine catabolic process to acetate
HMSLTHF_RS14835	COG5001	Diguanylate cyclase
HMSLTHF_RS14835	COG3300	MHYT domain
HMSLTHF_RS14840	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HMSLTHF_RS14845	COG0402	S-adenosylhomocysteine deaminase activity
HMSLTHF_RS14850	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HMSLTHF_RS14855	COG0456	acetyltransferase
HMSLTHF_RS14865	COG2818	Glycosylase
HMSLTHF_RS14870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HMSLTHF_RS14880	COG0384	phenazine biosynthesis protein PhzF
HMSLTHF_RS14885	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS14900	COG0765	amino acid transport
HMSLTHF_RS14925	COG1309	transcriptional regulator
HMSLTHF_RS14950	COG1802	Transcriptional regulator
HMSLTHF_RS14960	COG0154	amidase activity
HMSLTHF_RS14970	COG1441	menaquinone biosynthetic process
HMSLTHF_RS14990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HMSLTHF_RS14995	COG1053	succinate dehydrogenase
HMSLTHF_RS15010	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HMSLTHF_RS15015	COG1169	isochorismate synthase
HMSLTHF_RS15025	COG1575	Belongs to the MenA family. Type 1 subfamily
HMSLTHF_RS15030	COG2329	Antibiotic biosynthesis monooxygenase
HMSLTHF_RS15035	COG1902	pentaerythritol trinitrate reductase activity
HMSLTHF_RS15040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HMSLTHF_RS15070	COG1902	pentaerythritol trinitrate reductase activity
HMSLTHF_RS15085	COG0488	(ABC) transporter
HMSLTHF_RS15130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HMSLTHF_RS15140	COG2084	Dehydrogenase
HMSLTHF_RS15160	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HMSLTHF_RS15165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HMSLTHF_RS15170	COG3622	Belongs to the hyi family
HMSLTHF_RS15175	COG0235	Class ii aldolase
HMSLTHF_RS15180	COG3395	kinase activity
HMSLTHF_RS15185	COG2084	Dehydrogenase
HMSLTHF_RS15190	COG1609	Transcriptional regulator
HMSLTHF_RS15205	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HMSLTHF_RS15215	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HMSLTHF_RS15225	COG2186	Transcriptional regulator
HMSLTHF_RS15230	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS15245	COG2239	Acts as a magnesium transporter
HMSLTHF_RS15295	COG3706	GGDEF domain
HMSLTHF_RS15300	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HMSLTHF_RS15315	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS15320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HMSLTHF_RS15325	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HMSLTHF_RS15330	COG1984	allophanate hydrolase subunit 2
HMSLTHF_RS15335	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HMSLTHF_RS15345	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HMSLTHF_RS15350	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HMSLTHF_RS15365	COG0010	Belongs to the arginase family
HMSLTHF_RS15395	COG0438	transferase activity, transferring glycosyl groups
HMSLTHF_RS15395	COG1216	Glycosyl transferase, family 2
HMSLTHF_RS15425	COG0662	Cupin 2, conserved barrel domain protein
HMSLTHF_RS15425	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HMSLTHF_RS15435	COG0463	Glycosyl transferase, family 2
HMSLTHF_RS15435	COG1216	Glycosyl transferase, family 2
HMSLTHF_RS15455	COG1215	transferase activity, transferring glycosyl groups
HMSLTHF_RS15465	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HMSLTHF_RS15475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HMSLTHF_RS15480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HMSLTHF_RS15490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HMSLTHF_RS15530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HMSLTHF_RS15570	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HMSLTHF_RS15585	COG0840	transmembrane signaling receptor activity
HMSLTHF_RS15590	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HMSLTHF_RS15595	COG0830	nickel cation binding
HMSLTHF_RS15600	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HMSLTHF_RS15605	COG0804	urea catabolic process
HMSLTHF_RS15610	COG0832	Belongs to the urease beta subunit family
HMSLTHF_RS15615	COG0831	urea catabolic process
HMSLTHF_RS15620	COG0829	nickel cation binding
HMSLTHF_RS15635	COG3706	GGDEF domain
HMSLTHF_RS15680	COG4565	transcriptional regulatory protein
HMSLTHF_RS15685	COG3290	protein histidine kinase activity
HMSLTHF_RS15700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HMSLTHF_RS15705	COG1116	anion transmembrane transporter activity
HMSLTHF_RS15710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HMSLTHF_RS15715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HMSLTHF_RS15720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HMSLTHF_RS15725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HMSLTHF_RS15730	COG1028	Short-chain dehydrogenase reductase Sdr
HMSLTHF_RS15735	COG0668	transmembrane transport
HMSLTHF_RS15740	COG1238	metal cluster binding
HMSLTHF_RS15745	COG1414	Transcriptional regulator
HMSLTHF_RS15755	COG1741	Belongs to the pirin family
HMSLTHF_RS15760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HMSLTHF_RS15765	COG1722	exodeoxyribonuclease VII activity
HMSLTHF_RS15770	COG0142	geranyltranstransferase activity
HMSLTHF_RS15775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HMSLTHF_RS15780	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HMSLTHF_RS15785	COG0625	glutathione transferase activity
HMSLTHF_RS15815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HMSLTHF_RS15845	COG2205	protein histidine kinase activity
HMSLTHF_RS15845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMSLTHF_RS15855	COG5002	protein histidine kinase activity
HMSLTHF_RS15855	COG2198	Histidine kinase
HMSLTHF_RS15855	COG0784	Response regulator, receiver
HMSLTHF_RS15865	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HMSLTHF_RS15870	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HMSLTHF_RS15875	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HMSLTHF_RS15885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMSLTHF_RS15890	COG4597	amino acid ABC transporter
HMSLTHF_RS15895	COG0765	amino acid transport
HMSLTHF_RS15900	COG1126	abc transporter atp-binding protein
HMSLTHF_RS15915	COG0840	transmembrane signaling receptor activity
HMSLTHF_RS15925	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS15940	COG0004	ammonium transporteR
HMSLTHF_RS15955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HMSLTHF_RS15985	COG2002	toxin-antitoxin pair type II binding
HMSLTHF_RS15990	COG0606	chelatase, subunit chli
HMSLTHF_RS16000	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HMSLTHF_RS16010	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HMSLTHF_RS16015	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HMSLTHF_RS16020	COG2080	2 iron, 2 sulfur cluster binding
HMSLTHF_RS16045	COG2363	Small membrane protein
HMSLTHF_RS16060	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HMSLTHF_RS16080	COG1999	signal sequence binding
HMSLTHF_RS16090	COG0545	Peptidyl-prolyl cis-trans isomerase
HMSLTHF_RS16095	COG0589	response to stress
HMSLTHF_RS16100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HMSLTHF_RS16105	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HMSLTHF_RS16110	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HMSLTHF_RS16120	COG0488	(ABC) transporter
HMSLTHF_RS16125	COG1490	D-aminoacyl-tRNA deacylase activity
HMSLTHF_RS16140	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HMSLTHF_RS16155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HMSLTHF_RS16165	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HMSLTHF_RS16170	COG1011	Hydrolase
HMSLTHF_RS16175	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HMSLTHF_RS16185	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HMSLTHF_RS16190	COG0019	diaminopimelate decarboxylase activity
HMSLTHF_RS16200	COG0165	Argininosuccinate lyase
HMSLTHF_RS16220	COG2959	enzyme of heme biosynthesis
HMSLTHF_RS16230	COG1970	mechanosensitive ion channel activity
HMSLTHF_RS16235	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HMSLTHF_RS16240	COG5383	Protein conserved in bacteria
HMSLTHF_RS16245	COG1801	Protein of unknown function DUF72
HMSLTHF_RS16250	COG0733	neurotransmitter:sodium symporter activity
HMSLTHF_RS16260	COG1737	Transcriptional regulator
HMSLTHF_RS16265	COG0210	DNA helicase
HMSLTHF_RS16270	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HMSLTHF_RS16290	COG0581	inorganic phosphate transmembrane transporter activity
HMSLTHF_RS16295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HMSLTHF_RS16300	COG0704	Plays a role in the regulation of phosphate uptake
HMSLTHF_RS16330	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HMSLTHF_RS16335	COG3161	chorismate lyase activity
HMSLTHF_RS16355	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS16360	COG1012	belongs to the aldehyde dehydrogenase family
HMSLTHF_RS16370	COG1473	amidohydrolase
HMSLTHF_RS16385	COG1289	transmembrane transporter activity
HMSLTHF_RS16390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HMSLTHF_RS16395	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS16410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HMSLTHF_RS16415	COG1758	RNA polymerase activity
HMSLTHF_RS16420	COG0194	GDP metabolic process
HMSLTHF_RS16435	COG2814	Major facilitator Superfamily
HMSLTHF_RS16515	COG3547	Transposase (IS116 IS110 IS902 family)
HMSLTHF_RS16535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HMSLTHF_RS16540	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HMSLTHF_RS16555	COG0497	DNA recombination
HMSLTHF_RS16595	COG1561	YicC-like family, N-terminal region
HMSLTHF_RS16600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HMSLTHF_RS16610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HMSLTHF_RS16615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HMSLTHF_RS16620	COG0210	DNA helicase
HMSLTHF_RS16635	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HMSLTHF_RS16645	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HMSLTHF_RS16650	COG1477	protein flavinylation
HMSLTHF_RS16655	COG1968	undecaprenyl-diphosphatase activity
HMSLTHF_RS16665	COG2239	Acts as a magnesium transporter
HMSLTHF_RS16670	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HMSLTHF_RS16675	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HMSLTHF_RS16680	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HMSLTHF_RS16685	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HMSLTHF_RS16690	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HMSLTHF_RS16695	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HMSLTHF_RS16705	COG0356	it plays a direct role in the translocation of protons across the membrane
HMSLTHF_RS16715	COG1475	DNA binding
HMSLTHF_RS16720	COG1192	Involved in chromosome partitioning
HMSLTHF_RS16725	COG0357	Ribosomal RNA small subunit methyltransferase G
HMSLTHF_RS16730	COG0445	tRNA wobble uridine modification
HMSLTHF_RS16735	COG1126	abc transporter atp-binding protein
HMSLTHF_RS16740	COG0765	amino acid transport
HMSLTHF_RS16745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HMSLTHF_RS16750	COG0316	Belongs to the HesB IscA family
HMSLTHF_RS16755	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HMSLTHF_RS16760	COG0038	chloride channel
HMSLTHF_RS16770	COG0351	phosphomethylpyrimidine kinase
HMSLTHF_RS16775	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HMSLTHF_RS16795	COG1462	curli production assembly transport component CsgG
HMSLTHF_RS16820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HMSLTHF_RS16825	COG2885	chlorophyll binding
HMSLTHF_RS16830	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HMSLTHF_RS16835	COG3549	Plasmid maintenance system killer
HMSLTHF_RS16840	COG3093	addiction module antidote protein HigA
HMSLTHF_RS16850	COG3038	cytochrome b561
HMSLTHF_RS16855	COG0667	Aldo Keto reductase
HMSLTHF_RS16860	COG1028	Short-chain dehydrogenase reductase Sdr
HMSLTHF_RS16865	COG3384	dioxygenase
HMSLTHF_RS16870	COG0583	DNA-binding transcription factor activity
HMSLTHF_RS16890	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HMSLTHF_RS16895	COG0706	membrane insertase activity
HMSLTHF_RS16900	COG0594	ribonuclease P activity
HMSLTHF_RS16905	COG0230	Belongs to the bacterial ribosomal protein bL34 family