locus-tag	class	description
BWR19_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BWR19_RS00010	COG0592	DNA-directed DNA polymerase activity
BWR19_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BWR19_RS00030	COG0751	glycine-tRNA ligase activity
BWR19_RS00035	COG0752	glycyl-tRNA synthetase alpha subunit
BWR19_RS00040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BWR19_RS00055	COG0463	Glycosyl transferase, family 2
BWR19_RS00060	COG0859	PFAM glycosyl transferase family 9
BWR19_RS00065	COG0438	transferase activity, transferring glycosyl groups
BWR19_RS00070	COG3642	lipopolysaccharide core region biosynthetic process
BWR19_RS00075	COG0859	PFAM glycosyl transferase family 9
BWR19_RS00080	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BWR19_RS00080	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BWR19_RS00085	COG1519	Transferase
BWR19_RS00090	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BWR19_RS00095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BWR19_RS00100	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BWR19_RS00120	COG0006	proline dipeptidase activity
BWR19_RS00125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BWR19_RS00135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BWR19_RS00150	COG1176	ABC-type spermidine putrescine transport system, permease component I
BWR19_RS00160	COG3842	ATPase activity
BWR19_RS00165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BWR19_RS00170	COG0793	Belongs to the peptidase S41A family
BWR19_RS00175	COG4942	peptidase
BWR19_RS00180	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BWR19_RS00185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BWR19_RS00190	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BWR19_RS00195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BWR19_RS00200	COG2186	Transcriptional regulator
BWR19_RS00205	COG0747	negative chemotaxis
BWR19_RS00210	COG0601	transmembrane transport
BWR19_RS00215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BWR19_RS00220	COG0444	Belongs to the ABC transporter superfamily
BWR19_RS00225	COG4608	Belongs to the ABC transporter superfamily
BWR19_RS00235	COG2084	Dehydrogenase
BWR19_RS00240	COG2721	sulfolactate sulfo-lyase activity
BWR19_RS00245	COG2084	Dehydrogenase
BWR19_RS00250	COG1454	alcohol dehydrogenase
BWR19_RS00265	COG2996	Protein conserved in bacteria
BWR19_RS00270	COG0189	ligase activity
BWR19_RS00280	COG1678	Uncharacterized ACR, COG1678
BWR19_RS00285	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BWR19_RS00295	COG0540	Belongs to the ATCase OTCase family
BWR19_RS00305	COG3648	Uricase
BWR19_RS00305	COG3195	allantoin biosynthetic process
BWR19_RS00310	COG2351	hydroxyisourate hydrolase activity
BWR19_RS00350	COG1288	antiporter activity
BWR19_RS00360	COG3257	ureidoglycine aminohydrolase activity
BWR19_RS00365	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
BWR19_RS00370	COG3960	tartronate-semialdehyde synthase activity
BWR19_RS00375	COG3622	Belongs to the hyi family
BWR19_RS00380	COG2084	Dehydrogenase
BWR19_RS00405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BWR19_RS00410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BWR19_RS00415	COG0154	amidase activity
BWR19_RS00445	COG2079	MmgE PrpD family protein
BWR19_RS00450	COG1028	Short-chain dehydrogenase reductase Sdr
BWR19_RS00460	COG0596	Alpha beta hydrolase
BWR19_RS00465	COG1802	Transcriptional regulator
BWR19_RS00470	COG1802	Transcriptional regulator
BWR19_RS00485	COG0473	3-isopropylmalate dehydrogenase activity
BWR19_RS00515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BWR19_RS00525	COG4948	Mandelate Racemase Muconate Lactonizing
BWR19_RS00540	COG1054	Belongs to the UPF0176 family
BWR19_RS00545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BWR19_RS00550	COG1722	exodeoxyribonuclease VII activity
BWR19_RS00555	COG0142	geranyltranstransferase activity
BWR19_RS00560	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BWR19_RS00565	COG2963	transposase activity
BWR19_RS00570	COG2801	Transposase and inactivated derivatives
BWR19_RS00625	COG3829	transcription factor binding
BWR19_RS00655	COG3501	Rhs element vgr protein
BWR19_RS00680	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BWR19_RS00685	COG0625	glutathione transferase activity
BWR19_RS00690	COG1272	protein, Hemolysin III
BWR19_RS00695	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BWR19_RS00700	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BWR19_RS00710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BWR19_RS00715	COG4597	amino acid ABC transporter
BWR19_RS00720	COG0765	amino acid transport
BWR19_RS00725	COG1126	abc transporter atp-binding protein
BWR19_RS00730	COG3706	GGDEF domain
BWR19_RS00750	COG3639	organic phosphonate transmembrane transporter activity
BWR19_RS00770	COG0583	DNA-binding transcription factor activity
BWR19_RS00785	COG0004	ammonium transporteR
BWR19_RS00815	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BWR19_RS00825	COG2363	Small membrane protein
BWR19_RS00835	COG2022	thiamine diphosphate biosynthetic process
BWR19_RS00840	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BWR19_RS00855	COG1999	signal sequence binding
BWR19_RS00865	COG0545	Peptidyl-prolyl cis-trans isomerase
BWR19_RS00870	COG0589	response to stress
BWR19_RS00875	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWR19_RS00880	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BWR19_RS00885	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWR19_RS00895	COG0488	(ABC) transporter
BWR19_RS00900	COG1490	D-aminoacyl-tRNA deacylase activity
BWR19_RS00920	COG1238	metal cluster binding
BWR19_RS00925	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWR19_RS00940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BWR19_RS00950	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BWR19_RS00955	COG1011	Hydrolase
BWR19_RS00960	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BWR19_RS00970	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BWR19_RS00975	COG0019	diaminopimelate decarboxylase activity
BWR19_RS00985	COG0165	Argininosuccinate lyase
BWR19_RS00990	COG0181	hydroxymethylbilane synthase activity
BWR19_RS01000	COG2959	enzyme of heme biosynthesis
BWR19_RS01010	COG2252	PERMEase
BWR19_RS01015	COG0668	transmembrane transport
BWR19_RS01030	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BWR19_RS01035	COG0189	ligase activity
BWR19_RS01035	COG4067	protein conserved in archaea
BWR19_RS01045	COG0527	aspartate kinase activity
BWR19_RS01055	COG1748	Saccharopine dehydrogenase
BWR19_RS01060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BWR19_RS01065	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BWR19_RS01085	COG2186	Transcriptional regulator
BWR19_RS01090	COG0473	3-isopropylmalate dehydrogenase activity
BWR19_RS01090	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BWR19_RS01110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BWR19_RS01115	COG2867	negative regulation of translational initiation
BWR19_RS01125	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BWR19_RS01135	COG0497	DNA recombination
BWR19_RS01140	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BWR19_RS01145	COG0443	Heat shock 70 kDa protein
BWR19_RS01150	COG0484	heat shock protein binding
BWR19_RS01170	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BWR19_RS01195	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BWR19_RS01200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BWR19_RS01205	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BWR19_RS01210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BWR19_RS01215	COG0149	triose-phosphate isomerase activity
BWR19_RS01220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BWR19_RS01235	COG0779	Required for maturation of 30S ribosomal subunits
BWR19_RS01240	COG0195	Participates in both transcription termination and antitermination
BWR19_RS01245	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BWR19_RS01250	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BWR19_RS01255	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BWR19_RS01260	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BWR19_RS01265	COG1185	polyribonucleotide nucleotidyltransferase activity
BWR19_RS01275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BWR19_RS01280	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BWR19_RS01290	COG0617	tRNA 3'-terminal CCA addition
BWR19_RS01300	COG4191	Histidine kinase
BWR19_RS01305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BWR19_RS01310	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BWR19_RS01315	COG0436	Aminotransferase
BWR19_RS01320	COG1489	DNA binding
BWR19_RS01330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BWR19_RS01335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BWR19_RS01360	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BWR19_RS01365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BWR19_RS01370	COG2963	transposase activity
BWR19_RS01375	COG2801	Transposase and inactivated derivatives
BWR19_RS01420	COG3022	response to hydroperoxide
BWR19_RS01425	COG0667	Aldo Keto reductase
BWR19_RS01455	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BWR19_RS01470	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BWR19_RS01475	COG3118	belongs to the thioredoxin family
BWR19_RS01495	COG1959	2 iron, 2 sulfur cluster binding
BWR19_RS01500	COG2832	Protein of unknown function (DUF454)
BWR19_RS01510	COG3154	lipid carrier protein
BWR19_RS01515	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BWR19_RS01530	COG0826	peptidase U32
BWR19_RS01535	COG0826	peptidase U32
BWR19_RS01540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BWR19_RS01540	COG1017	nitric oxide dioxygenase activity
BWR19_RS01570	COG2223	nitrite transmembrane transporter activity
BWR19_RS01585	COG2197	response regulator
BWR19_RS01590	COG3850	Histidine kinase
BWR19_RS01600	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BWR19_RS01605	COG1140	nitrate reductase beta subunit
BWR19_RS01610	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BWR19_RS01615	COG2181	nitrate reductase activity
BWR19_RS01620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BWR19_RS01625	COG0521	Mo-molybdopterin cofactor biosynthetic process
BWR19_RS01630	COG0303	'Molybdopterin
BWR19_RS01645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BWR19_RS01680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BWR19_RS01750	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BWR19_RS01795	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BWR19_RS01840	COG1205	dead DEAH box helicase
BWR19_RS01840	COG1111	helicase
BWR19_RS01845	COG0210	DNA helicase
BWR19_RS01865	COG0582	viral genome integration into host DNA
BWR19_RS01885	COG1028	Short-chain dehydrogenase reductase Sdr
BWR19_RS01895	COG0850	regulation of cytokinetic process
BWR19_RS01900	COG2894	cell division
BWR19_RS01905	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BWR19_RS01910	COG2925	Exonuclease
BWR19_RS01930	COG2814	Major facilitator Superfamily
BWR19_RS01935	COG4536	flavin adenine dinucleotide binding
BWR19_RS01945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BWR19_RS01950	COG0228	four-way junction DNA binding
BWR19_RS01955	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BWR19_RS01960	COG0336	Belongs to the RNA methyltransferase TrmD family
BWR19_RS01965	COG0335	large ribosomal subunit rRNA binding
BWR19_RS01970	COG4974	Belongs to the 'phage' integrase family
BWR19_RS01975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BWR19_RS01990	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BWR19_RS02000	COG2217	Heavy metal translocating P-type atpase
BWR19_RS02005	COG0789	Transcriptional regulator
BWR19_RS02020	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BWR19_RS02030	COG2814	Major facilitator Superfamily
BWR19_RS02035	COG0271	Belongs to the BolA IbaG family
BWR19_RS02055	COG0742	ribosomal rna small subunit methyltransferase
BWR19_RS02060	COG0552	protein localization to endoplasmic reticulum
BWR19_RS02065	COG2884	Cell division ATP-binding protein ftsE
BWR19_RS02070	COG2177	Part of the ABC transporter FtsEX involved in
BWR19_RS02080	COG1309	transcriptional regulator
BWR19_RS02085	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BWR19_RS02100	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BWR19_RS02105	COG2003	Belongs to the UPF0758 family
BWR19_RS02110	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BWR19_RS02115	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BWR19_RS02120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BWR19_RS02125	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BWR19_RS02140	COG0686	Belongs to the AlaDH PNT family
BWR19_RS02150	COG2391	methyltransferase activity
BWR19_RS02170	COG0450	alkyl hydroperoxide reductase
BWR19_RS02175	COG0492	ferredoxin-NADP+ reductase activity
BWR19_RS02195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BWR19_RS02205	COG1393	Belongs to the ArsC family
BWR19_RS02210	COG0436	Aminotransferase
BWR19_RS02215	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BWR19_RS02225	COG0052	Belongs to the universal ribosomal protein uS2 family
BWR19_RS02230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BWR19_RS02235	COG0528	UMP kinase activity
BWR19_RS02240	COG0233	cytoplasmic translational termination
BWR19_RS02255	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BWR19_RS02275	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BWR19_RS02280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BWR19_RS02285	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BWR19_RS02290	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BWR19_RS02295	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BWR19_RS02300	COG0587	DNA-directed DNA polymerase activity
BWR19_RS02305	COG0825	malonyl-CoA metabolic process
BWR19_RS02310	COG0037	tRNA processing
BWR19_RS02315	COG0248	Ppx GppA phosphatase
BWR19_RS02325	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BWR19_RS02340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BWR19_RS02360	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BWR19_RS02370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BWR19_RS02375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BWR19_RS02380	COG0140	phosphoribosyl-ATP diphosphatase activity
BWR19_RS02385	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BWR19_RS02405	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BWR19_RS02410	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BWR19_RS02420	COG0018	arginyl-trna synthetase
BWR19_RS02425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BWR19_RS02430	COG0254	rRNA binding
BWR19_RS02435	COG0281	malic enzyme
BWR19_RS02475	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BWR19_RS02480	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BWR19_RS02485	COG0069	glutamate synthase activity
BWR19_RS02485	COG0067	glutamate synthase
BWR19_RS02485	COG0070	glutamate synthase
BWR19_RS02490	COG0493	'glutamate synthase
BWR19_RS02495	COG0504	CTP synthase activity
BWR19_RS02500	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BWR19_RS02505	COG0148	phosphopyruvate hydratase activity
BWR19_RS02510	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BWR19_RS02515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BWR19_RS02520	COG1546	Belongs to the CinA family
BWR19_RS02525	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BWR19_RS02530	COG2137	regulation of response to DNA damage stimulus
BWR19_RS02535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BWR19_RS02540	COG0527	aspartate kinase activity
BWR19_RS02545	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BWR19_RS02575	COG5016	pyruvate
BWR19_RS02575	COG0511	ligase activity, forming carbon-carbon bonds
BWR19_RS02580	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BWR19_RS02595	COG3181	Tripartite tricarboxylate transporter family receptor
BWR19_RS02620	COG2059	Chromate
BWR19_RS02625	COG2059	Chromate
BWR19_RS02630	COG0179	Fumarylacetoacetate (FAA) hydrolase
BWR19_RS02635	COG3181	Tripartite tricarboxylate transporter family receptor
BWR19_RS02650	COG2059	Chromate
BWR19_RS02655	COG2059	Chromate
BWR19_RS02660	COG1802	Transcriptional regulator
BWR19_RS02665	COG1739	Uncharacterized protein family UPF0029
BWR19_RS02670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BWR19_RS02675	COG4133	protoheme IX ABC transporter activity
BWR19_RS02690	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BWR19_RS02695	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BWR19_RS02710	COG3088	subunit of a heme lyase
BWR19_RS02720	COG1196	nuclear chromosome segregation
BWR19_RS02725	COG3115	cell septum assembly
BWR19_RS02730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BWR19_RS02740	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BWR19_RS02740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BWR19_RS02745	COG2350	Protein conserved in bacteria
BWR19_RS02750	COG0613	PHP domain protein
BWR19_RS02755	COG0009	L-threonylcarbamoyladenylate synthase
BWR19_RS02760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BWR19_RS02765	COG3025	triphosphatase activity
BWR19_RS02770	COG1392	Phosphate transport regulator
BWR19_RS02775	COG0306	phosphate transporter
BWR19_RS02780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BWR19_RS02780	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BWR19_RS02785	COG2205	protein histidine kinase activity
BWR19_RS02795	COG2204	response regulator
BWR19_RS02800	COG1570	exodeoxyribonuclease VII activity
BWR19_RS02810	COG3237	CsbD-like
BWR19_RS02820	COG0519	Catalyzes the synthesis of GMP from XMP
BWR19_RS02820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BWR19_RS02860	COG3550	peptidyl-serine autophosphorylation
BWR19_RS02865	COG1396	sequence-specific DNA binding
BWR19_RS02875	COG0427	acetyl-CoA hydrolase
BWR19_RS02895	COG2130	NADP-dependent
BWR19_RS02935	COG1278	Cold shock
BWR19_RS02945	COG1278	Cold shock
BWR19_RS02950	COG0625	glutathione transferase activity
BWR19_RS02955	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BWR19_RS02960	COG4251	negative regulation of phosphorylation
BWR19_RS02960	COG3706	GGDEF domain
BWR19_RS02960	COG2203	Gaf domain
BWR19_RS02960	COG5001	Diguanylate cyclase
BWR19_RS02995	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWR19_RS03015	COG0513	Belongs to the DEAD box helicase family
BWR19_RS03025	COG0840	transmembrane signaling receptor activity
BWR19_RS03030	COG1402	creatininase
BWR19_RS03040	COG0705	Rhomboid family
BWR19_RS03045	COG1073	alpha beta
BWR19_RS03050	COG0006	proline dipeptidase activity
BWR19_RS03060	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BWR19_RS03075	COG0217	transcriptional regulatory protein
BWR19_RS03090	COG1946	Acyl-CoA thioesterase
BWR19_RS03100	COG3706	GGDEF domain
BWR19_RS03105	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BWR19_RS03120	COG1061	Type III restriction enzyme res subunit
BWR19_RS03125	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BWR19_RS03130	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BWR19_RS03150	COG5001	Diguanylate cyclase
BWR19_RS03150	COG3447	MASE1 domain protein
BWR19_RS03150	COG5002	protein histidine kinase activity
BWR19_RS03170	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BWR19_RS03175	COG4783	chaperone-mediated protein folding
BWR19_RS03180	COG0425	Belongs to the sulfur carrier protein TusA family
BWR19_RS03190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BWR19_RS03195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BWR19_RS03205	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BWR19_RS03210	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BWR19_RS03215	COG1720	tRNA m6t6A37 methyltransferase activity
BWR19_RS03240	COG0563	adenylate kinase activity
BWR19_RS03250	COG0742	ribosomal rna small subunit methyltransferase
BWR19_RS03260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BWR19_RS03275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BWR19_RS03285	COG2205	protein histidine kinase activity
BWR19_RS03285	COG2198	Histidine kinase
BWR19_RS03285	COG0784	Response regulator, receiver
BWR19_RS03295	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BWR19_RS03315	COG0037	tRNA processing
BWR19_RS03320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BWR19_RS03330	COG2963	transposase activity
BWR19_RS03335	COG2801	Transposase and inactivated derivatives
BWR19_RS03350	COG2217	Heavy metal translocating P-type atpase
BWR19_RS03360	COG0348	domain, Protein
BWR19_RS03365	COG2010	Cytochrome c
BWR19_RS03380	COG3278	Belongs to the heme-copper respiratory oxidase family
BWR19_RS03420	COG1902	pentaerythritol trinitrate reductase activity
BWR19_RS03420	COG0446	pyridine nucleotide-disulphide oxidoreductase
BWR19_RS03430	COG0784	Response regulator, receiver
BWR19_RS03430	COG2205	protein histidine kinase activity
BWR19_RS03470	COG2766	serine protein kinase
BWR19_RS03475	COG2718	Belongs to the UPF0229 family
BWR19_RS03480	COG2719	SpoVR family
BWR19_RS03505	COG2010	Cytochrome c
BWR19_RS03505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BWR19_RS03510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BWR19_RS03550	COG0557	exoribonuclease II activity
BWR19_RS03560	COG0360	Binds together with S18 to 16S ribosomal RNA
BWR19_RS03565	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BWR19_RS03575	COG0359	binds to the 23S rRNA
BWR19_RS03585	COG4948	Mandelate Racemase Muconate Lactonizing
BWR19_RS03590	COG3734	2-keto-3-deoxy-galactonokinase
BWR19_RS03595	COG0800	Aldolase
BWR19_RS03600	COG0305	Participates in initiation and elongation during chromosome replication
BWR19_RS03620	COG3046	protein related to deoxyribodipyrimidine photolyase
BWR19_RS03630	COG1320	monovalent cation:proton antiporter activity
BWR19_RS03635	COG2212	antiporter activity
BWR19_RS03645	COG0651	ATP synthesis coupled electron transport
BWR19_RS03650	COG1006	Multisubunit Na H antiporter MnhC subunit
BWR19_RS03655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BWR19_RS03655	COG2111	Na H antiporter
BWR19_RS03660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BWR19_RS03660	COG2111	Na H antiporter
BWR19_RS03665	COG2111	Na H antiporter
BWR19_RS03670	COG1006	Multisubunit Na H antiporter MnhC subunit
BWR19_RS03675	COG0651	ATP synthesis coupled electron transport
BWR19_RS03680	COG1863	multisubunit Na H antiporter MnhE subunit
BWR19_RS03685	COG2212	antiporter activity
BWR19_RS03690	COG1320	monovalent cation:proton antiporter activity
BWR19_RS03700	COG0415	Belongs to the DNA photolyase family
BWR19_RS03710	COG2951	lytic endotransglycosylase activity
BWR19_RS03720	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
BWR19_RS03730	COG3954	Phosphoribulokinase
BWR19_RS03735	COG0537	adenosine 5'-monophosphoramidase activity
BWR19_RS03740	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BWR19_RS03755	COG3178	'Phosphotransferase
BWR19_RS03760	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BWR19_RS03765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BWR19_RS03775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BWR19_RS03780	COG2967	ApaG domain
BWR19_RS03785	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BWR19_RS03790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BWR19_RS03795	COG0617	tRNA 3'-terminal CCA addition
BWR19_RS03800	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BWR19_RS03800	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BWR19_RS03805	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BWR19_RS03810	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BWR19_RS03815	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BWR19_RS03820	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BWR19_RS03825	COG0358	DNA primase activity
BWR19_RS03835	COG0583	DNA-binding transcription factor activity
BWR19_RS03840	COG1760	l-serine dehydratase
BWR19_RS03850	COG0583	DNA-binding transcription factor activity
BWR19_RS03855	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BWR19_RS03870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BWR19_RS03885	COG0446	pyridine nucleotide-disulphide oxidoreductase
BWR19_RS03885	COG1902	pentaerythritol trinitrate reductase activity
BWR19_RS03890	COG0247	lactate metabolic process
BWR19_RS03890	COG2181	nitrate reductase activity
BWR19_RS03895	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BWR19_RS03905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BWR19_RS03910	COG5001	Diguanylate cyclase
BWR19_RS03915	COG5001	Diguanylate cyclase
BWR19_RS03915	COG3300	MHYT domain
BWR19_RS03940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BWR19_RS03950	COG3237	CsbD-like
BWR19_RS03960	COG3383	formate dehydrogenase (NAD+) activity
BWR19_RS03985	COG4191	Histidine kinase
BWR19_RS04000	COG0446	pyridine nucleotide-disulphide oxidoreductase
BWR19_RS04000	COG1902	pentaerythritol trinitrate reductase activity
BWR19_RS04010	COG2133	pyrroloquinoline quinone binding
BWR19_RS04020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BWR19_RS04050	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BWR19_RS04055	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BWR19_RS04060	COG1780	Probably involved in ribonucleotide reductase function
BWR19_RS04065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BWR19_RS04070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BWR19_RS04100	COG0471	metal ion transport
BWR19_RS04105	COG0385	Bile acid
BWR19_RS04130	COG0412	Dienelactone hydrolase
BWR19_RS04145	COG2989	Protein conserved in bacteria
BWR19_RS04150	COG1278	Cold shock
BWR19_RS04155	COG0471	metal ion transport
BWR19_RS04155	COG3273	potassium ion transport
BWR19_RS04160	COG0400	carboxylic ester hydrolase activity
BWR19_RS04175	COG0651	ATP synthesis coupled electron transport
BWR19_RS04180	COG0651	ATP synthesis coupled electron transport
BWR19_RS04185	COG0651	ATP synthesis coupled electron transport
BWR19_RS04190	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BWR19_RS04200	COG0028	Belongs to the TPP enzyme family
BWR19_RS04230	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BWR19_RS04230	COG2146	nitrite reductase [NAD(P)H] activity
BWR19_RS04235	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BWR19_RS04240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BWR19_RS04245	COG3707	response regulator
BWR19_RS04250	COG0243	molybdopterin cofactor binding
BWR19_RS04255	COG1648	precorrin-2 dehydrogenase activity
BWR19_RS04255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BWR19_RS04265	COG0678	peroxiredoxin activity
BWR19_RS04270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BWR19_RS04300	COG1858	cytochrome C peroxidase
BWR19_RS04305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BWR19_RS04310	COG1695	Transcriptional regulator
BWR19_RS04320	COG1116	anion transmembrane transporter activity
BWR19_RS04325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BWR19_RS04330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BWR19_RS04335	COG3707	response regulator
BWR19_RS04340	COG2223	nitrite transmembrane transporter activity
BWR19_RS04350	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BWR19_RS04355	COG2963	transposase activity
BWR19_RS04360	COG2801	Transposase and inactivated derivatives
BWR19_RS04365	COG0739	heme binding
BWR19_RS04370	COG1741	Belongs to the pirin family
BWR19_RS04375	COG0583	DNA-binding transcription factor activity
BWR19_RS04380	COG0435	Glutathione S-transferase
BWR19_RS04385	COG1671	Belongs to the UPF0178 family
BWR19_RS04400	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWR19_RS04410	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWR19_RS04420	COG2084	Dehydrogenase
BWR19_RS04425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BWR19_RS04435	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWR19_RS04440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWR19_RS04455	COG0129	dihydroxy-acid dehydratase activity
BWR19_RS04470	COG1846	Transcriptional regulator
BWR19_RS04470	COG1940	carbohydrate kinase activity
BWR19_RS04475	COG1028	Short-chain dehydrogenase reductase Sdr
BWR19_RS04480	COG1129	ABC transporter
BWR19_RS04485	COG1172	Belongs to the binding-protein-dependent transport system permease family
BWR19_RS04490	COG1879	ABC-type sugar transport system periplasmic component
BWR19_RS04500	COG0673	inositol 2-dehydrogenase activity
BWR19_RS04515	COG2186	Transcriptional regulator
BWR19_RS04535	COG4948	Mandelate Racemase Muconate Lactonizing
BWR19_RS04585	COG0590	tRNA wobble adenosine to inosine editing
BWR19_RS04615	COG0300	oxidoreductase activity
BWR19_RS04620	COG2267	carboxylic ester hydrolase activity
BWR19_RS04630	COG0420	3'-5' exonuclease activity
BWR19_RS04650	COG1515	deoxyribonuclease V activity
BWR19_RS04655	COG0656	L-ascorbic acid biosynthetic process
BWR19_RS04670	COG1764	response to oxidative stress
BWR19_RS04675	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BWR19_RS04685	COG0668	transmembrane transport
BWR19_RS04710	COG0295	cytidine deaminase activity
BWR19_RS04715	COG0813	purine-nucleoside phosphorylase activity
BWR19_RS04720	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BWR19_RS04735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BWR19_RS04745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BWR19_RS04755	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BWR19_RS04760	COG0857	belongs to the CobB CobQ family
BWR19_RS04760	COG0280	phosphate acetyltransferase
BWR19_RS04765	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BWR19_RS04780	COG0318	PFAM AMP-dependent synthetase and ligase
BWR19_RS04790	COG2031	fatty acid transporter
BWR19_RS04810	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BWR19_RS04830	COG0297	glycogen (starch) synthase activity
BWR19_RS04865	COG2943	transferase activity, transferring hexosyl groups
BWR19_RS04870	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BWR19_RS04900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BWR19_RS04905	COG1127	ABC transporter
BWR19_RS04930	COG1250	3-hydroxyacyl-CoA dehydrogenase
BWR19_RS04935	COG1024	Enoyl-CoA hydratase
BWR19_RS04945	COG3608	succinylglutamate desuccinylase aspartoacylase
BWR19_RS04945	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BWR19_RS04960	COG1064	alcohol dehydrogenase
BWR19_RS04965	COG2207	Transcriptional regulator
BWR19_RS04975	COG0583	DNA-binding transcription factor activity
BWR19_RS04980	COG1028	Short-chain dehydrogenase reductase Sdr
BWR19_RS04990	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BWR19_RS04995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BWR19_RS05000	COG1063	alcohol dehydrogenase
BWR19_RS05070	COG0765	amino acid transport
BWR19_RS05075	COG0765	amino acid transport
BWR19_RS05085	COG0583	DNA-binding transcription factor activity
BWR19_RS05090	COG4221	oxidoreductase activity
BWR19_RS05095	COG2390	Transcriptional regulator
BWR19_RS05105	COG1175	transmembrane transport
BWR19_RS05115	COG3842	ATPase activity
BWR19_RS05120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BWR19_RS05130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BWR19_RS05140	COG1072	(Pantothenic acid kinase))
BWR19_RS05150	COG1070	Carbohydrate kinase
BWR19_RS05155	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BWR19_RS05165	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BWR19_RS05175	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
BWR19_RS05180	COG1116	anion transmembrane transporter activity
BWR19_RS05185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BWR19_RS05190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BWR19_RS05190	COG1116	anion transmembrane transporter activity
BWR19_RS05195	COG3604	Transcriptional regulator
BWR19_RS05205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWR19_RS05230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BWR19_RS05245	COG1716	ATPase activity
BWR19_RS05245	COG5001	Diguanylate cyclase
BWR19_RS05255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BWR19_RS05260	COG0166	Belongs to the GPI family
BWR19_RS05265	COG4989	oxidoreductase activity
BWR19_RS05275	COG0837	glucose binding
BWR19_RS05295	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BWR19_RS05300	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BWR19_RS05305	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BWR19_RS05310	COG0585	pseudouridine synthase activity
BWR19_RS05315	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BWR19_RS05320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BWR19_RS05340	COG1538	Outer membrane efflux protein
BWR19_RS05345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BWR19_RS05350	COG1560	Kdo2-lipid A biosynthetic process
BWR19_RS05360	COG0488	(ABC) transporter
BWR19_RS05370	COG1366	Belongs to the anti-sigma-factor antagonist family
BWR19_RS05395	COG4181	ATPase activity
BWR19_RS05400	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BWR19_RS05405	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BWR19_RS05425	COG1234	tRNA 3'-trailer cleavage
BWR19_RS05440	COG1215	transferase activity, transferring glycosyl groups
BWR19_RS05470	COG2391	methyltransferase activity
BWR19_RS05475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BWR19_RS05485	COG0366	Alpha amylase catalytic
BWR19_RS05490	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BWR19_RS05495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BWR19_RS05495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BWR19_RS05505	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BWR19_RS05510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BWR19_RS05520	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BWR19_RS05530	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BWR19_RS05540	COG0129	dihydroxy-acid dehydratase activity
BWR19_RS05545	COG0673	inositol 2-dehydrogenase activity
BWR19_RS05550	COG0494	nUDIX hydrolase
BWR19_RS05555	COG1011	Hydrolase
BWR19_RS05560	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BWR19_RS05565	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BWR19_RS05570	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BWR19_RS05575	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BWR19_RS05590	COG1028	Short-chain dehydrogenase reductase Sdr
BWR19_RS05610	COG1012	belongs to the aldehyde dehydrogenase family
BWR19_RS05620	COG1053	succinate dehydrogenase
BWR19_RS05630	COG2183	response to ionizing radiation
BWR19_RS05635	COG2918	glutathione biosynthetic process
BWR19_RS05640	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BWR19_RS05665	COG0579	oxidoreductase
BWR19_RS05675	COG0494	nUDIX hydrolase
BWR19_RS05690	COG3279	Response regulator of the LytR AlgR family
BWR19_RS05695	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BWR19_RS05700	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BWR19_RS05710	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
BWR19_RS05725	COG3842	ATPase activity
BWR19_RS05730	COG1176	ABC-type spermidine putrescine transport system, permease component I
BWR19_RS05735	COG1177	transmembrane transport
BWR19_RS05745	COG5001	Diguanylate cyclase
BWR19_RS05745	COG5002	protein histidine kinase activity
BWR19_RS05745	COG3447	MASE1 domain protein
BWR19_RS05750	COG0840	transmembrane signaling receptor activity
BWR19_RS05775	COG0840	transmembrane signaling receptor activity
BWR19_RS05795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BWR19_RS05800	COG2813	Specifically methylates the guanine in position
BWR19_RS05825	COG2010	Cytochrome c
BWR19_RS05845	COG0446	pyridine nucleotide-disulphide oxidoreductase
BWR19_RS05845	COG1902	pentaerythritol trinitrate reductase activity
BWR19_RS05850	COG1858	cytochrome C peroxidase
BWR19_RS05860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BWR19_RS05870	COG0494	nUDIX hydrolase
BWR19_RS05875	COG3151	Protein conserved in bacteria
BWR19_RS05880	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BWR19_RS05885	COG0175	sulfate reduction
BWR19_RS05890	COG2895	sulfate adenylyltransferase (ATP) activity
BWR19_RS05900	COG2738	Putative neutral zinc metallopeptidase
BWR19_RS05905	COG0500	methyltransferase
BWR19_RS05915	COG4106	trans-aconitate 2-methyltransferase activity
BWR19_RS05920	COG0166	Belongs to the GPI family
BWR19_RS05940	COG0560	Phosphoserine phosphatase
BWR19_RS05940	COG3830	Belongs to the UPF0237 family
BWR19_RS05950	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BWR19_RS05985	COG1116	anion transmembrane transporter activity
BWR19_RS06000	COG1509	lysine 2,3-aminomutase activity
BWR19_RS06005	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BWR19_RS06015	COG0688	phosphatidylethanolamine metabolic process
BWR19_RS06025	COG1162	GTPase activity
BWR19_RS06030	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BWR19_RS06040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BWR19_RS06040	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BWR19_RS06045	COG0802	atpase or kinase
BWR19_RS06050	COG0860	N-Acetylmuramoyl-L-alanine amidase
BWR19_RS06055	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BWR19_RS06060	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BWR19_RS06065	COG1923	regulation of RNA biosynthetic process
BWR19_RS06070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BWR19_RS06075	COG0330	HflC and HflK could
BWR19_RS06080	COG0330	HflC and HflK could
BWR19_RS06085	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BWR19_RS06090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BWR19_RS06125	COG1959	2 iron, 2 sulfur cluster binding
BWR19_RS06130	COG0719	Fe-S assembly protein
BWR19_RS06135	COG0396	ATPase activity
BWR19_RS06140	COG0719	Fe-S assembly protein
BWR19_RS06145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BWR19_RS06155	COG2949	membrane
BWR19_RS06165	COG0189	ligase activity
BWR19_RS06170	COG0189	ligase activity
BWR19_RS06170	COG4067	protein conserved in archaea
BWR19_RS06180	COG3098	single-species biofilm formation
BWR19_RS06200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BWR19_RS06215	COG0506	proline dehydrogenase activity
BWR19_RS06215	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BWR19_RS06215	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BWR19_RS06230	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BWR19_RS06290	COG0517	IMP dehydrogenase activity
BWR19_RS06290	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BWR19_RS06290	COG0617	tRNA 3'-terminal CCA addition
BWR19_RS06305	COG3842	ATPase activity
BWR19_RS06320	COG0395	ABC-type sugar transport system, permease component
BWR19_RS06345	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BWR19_RS06370	COG0189	ligase activity
BWR19_RS06380	COG1666	GTP binding
BWR19_RS06390	COG1116	anion transmembrane transporter activity
BWR19_RS06395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BWR19_RS06405	COG0730	response to heat
BWR19_RS06410	COG0154	amidase activity
BWR19_RS06420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BWR19_RS06425	COG1017	nitric oxide dioxygenase activity
BWR19_RS06425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BWR19_RS06480	COG0737	Belongs to the 5'-nucleotidase family
BWR19_RS06490	COG0438	transferase activity, transferring glycosyl groups
BWR19_RS06510	COG2267	carboxylic ester hydrolase activity
BWR19_RS06520	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BWR19_RS06525	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BWR19_RS06530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BWR19_RS06540	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BWR19_RS06545	COG0588	phosphoglycerate mutase activity
BWR19_RS06555	COG4206	TonB-dependent receptor
BWR19_RS06565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BWR19_RS06570	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BWR19_RS06575	COG1120	ATPase activity
BWR19_RS06580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BWR19_RS06595	COG1797	cobyrinic acid a,c-diamide synthase activity
BWR19_RS06630	COG2099	Precorrin-6x reductase
BWR19_RS06640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BWR19_RS06660	COG0210	DNA helicase
BWR19_RS06670	COG2875	Belongs to the precorrin methyltransferase family
BWR19_RS06685	COG0778	Nitroreductase
BWR19_RS06690	COG1492	cobalamin metabolic process
BWR19_RS06700	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BWR19_RS06720	COG1737	Transcriptional regulator
BWR19_RS06725	COG1024	Enoyl-CoA hydratase
BWR19_RS06735	COG1024	Enoyl-CoA hydratase
BWR19_RS06740	COG0471	metal ion transport
BWR19_RS06740	COG3273	potassium ion transport
BWR19_RS06755	COG4175	Glycine betaine
BWR19_RS06755	COG0517	IMP dehydrogenase activity
BWR19_RS06775	COG1309	transcriptional regulator
BWR19_RS06830	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BWR19_RS06840	COG0425	Belongs to the sulfur carrier protein TusA family
BWR19_RS06860	COG3101	peptidyl-lysine hydroxylation
BWR19_RS06875	COG0488	(ABC) transporter
BWR19_RS06880	COG0589	response to stress
BWR19_RS06905	COG0183	Belongs to the thiolase family
BWR19_RS06920	COG0583	DNA-binding transcription factor activity
BWR19_RS06930	COG0006	proline dipeptidase activity
BWR19_RS06935	COG3118	belongs to the thioredoxin family
BWR19_RS06965	COG2824	Alkylphosphonate utilization operon protein PhnA
BWR19_RS06970	COG0432	Pfam Uncharacterised protein family UPF0047
BWR19_RS06980	COG1881	PFAM PEBP family protein
BWR19_RS06985	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BWR19_RS07035	COG0582	viral genome integration into host DNA
BWR19_RS07055	COG0651	ATP synthesis coupled electron transport
BWR19_RS07070	COG1320	monovalent cation:proton antiporter activity
BWR19_RS07085	COG2056	Na+-H+ antiporter family
BWR19_RS07090	COG2986	histidine ammonia-lyase
BWR19_RS07100	COG0010	Belongs to the arginase family
BWR19_RS07105	COG1228	amidohydrolase
BWR19_RS07115	COG2188	Transcriptional regulator
BWR19_RS07125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BWR19_RS07130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BWR19_RS07135	COG1845	cytochrome c oxidase, subunit III
BWR19_RS07155	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BWR19_RS07155	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWR19_RS07160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWR19_RS07160	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BWR19_RS07165	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWR19_RS07180	COG0495	leucyl-tRNA aminoacylation
BWR19_RS07190	COG1596	polysaccharide export
BWR19_RS07195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BWR19_RS07220	COG1132	(ABC) transporter
BWR19_RS07235	COG0438	transferase activity, transferring glycosyl groups
BWR19_RS07245	COG2801	Transposase and inactivated derivatives
BWR19_RS07260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BWR19_RS07270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BWR19_RS07275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BWR19_RS07280	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BWR19_RS07305	COG0367	asparagine synthase
BWR19_RS07350	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BWR19_RS07355	COG0066	3-isopropylmalate dehydratase activity
BWR19_RS07360	COG0473	3-isopropylmalate dehydrogenase activity
BWR19_RS07395	COG0135	phosphoribosylanthranilate isomerase activity
BWR19_RS07410	COG0159	tryptophan synthase activity
BWR19_RS07415	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BWR19_RS07420	COG0285	dihydrofolate synthase activity
BWR19_RS07460	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BWR19_RS07465	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BWR19_RS07470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BWR19_RS07480	COG1254	Belongs to the acylphosphatase family
BWR19_RS07525	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BWR19_RS07540	COG0156	8-amino-7-oxononanoate synthase activity
BWR19_RS07545	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BWR19_RS07565	COG0302	gtp cyclohydrolase
BWR19_RS07570	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BWR19_RS07585	COG0138	bifunctional purine biosynthesis protein purh
BWR19_RS07600	COG2264	protein methyltransferase activity
BWR19_RS07610	COG0511	ligase activity, forming carbon-carbon bonds
BWR19_RS07625	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BWR19_RS07635	COG0205	6-phosphofructokinase activity
BWR19_RS07640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BWR19_RS07650	COG1280	lysine exporter protein (LysE YggA)
BWR19_RS07655	COG0586	Pfam SNARE associated Golgi protein
BWR19_RS07670	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BWR19_RS07675	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BWR19_RS07680	COG0799	negative regulation of ribosome biogenesis
BWR19_RS07685	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BWR19_RS07690	COG0768	penicillin binding
BWR19_RS07695	COG0772	Belongs to the SEDS family
BWR19_RS07700	COG2951	lytic endotransglycosylase activity
BWR19_RS07710	COG1686	Belongs to the peptidase S11 family
BWR19_RS07715	COG2921	Belongs to the UPF0250 family
BWR19_RS07720	COG0321	lipoyl(octanoyl) transferase activity
BWR19_RS07725	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BWR19_RS07735	COG0439	Biotin carboxylase
BWR19_RS07740	COG5016	pyruvate
BWR19_RS07740	COG0511	ligase activity, forming carbon-carbon bonds
BWR19_RS07750	COG1803	Methylglyoxal synthase
BWR19_RS07800	COG0488	(ABC) transporter
BWR19_RS07820	COG2207	Transcriptional regulator
BWR19_RS07845	COG4964	Belongs to the GSP D family
BWR19_RS07890	COG4251	negative regulation of phosphorylation
BWR19_RS07890	COG3706	GGDEF domain
BWR19_RS07890	COG2203	Gaf domain
BWR19_RS07890	COG5001	Diguanylate cyclase
BWR19_RS07895	COG1376	ErfK ybiS ycfS ynhG family protein
BWR19_RS07900	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BWR19_RS07910	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BWR19_RS07915	COG1805	sodium ion transport
BWR19_RS07920	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BWR19_RS07930	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BWR19_RS07935	COG2871	sodium ion transport
BWR19_RS07950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BWR19_RS07960	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BWR19_RS07965	COG0237	dephospho-CoA kinase activity
BWR19_RS08025	COG2885	chlorophyll binding
BWR19_RS08030	COG2274	protein secretion by the type I secretion system
BWR19_RS08035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWR19_RS08055	COG5001	Diguanylate cyclase
BWR19_RS08075	COG2974	May be involved in recombination
BWR19_RS08095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BWR19_RS08100	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BWR19_RS08145	COG0653	protein targeting
BWR19_RS08160	COG1609	Transcriptional regulator
BWR19_RS08165	COG2084	Dehydrogenase
BWR19_RS08170	COG3395	kinase activity
BWR19_RS08175	COG0235	Class ii aldolase
BWR19_RS08180	COG3622	Belongs to the hyi family
BWR19_RS08185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BWR19_RS08190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWR19_RS08200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWR19_RS08200	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BWR19_RS08205	COG1012	belongs to the aldehyde dehydrogenase family
BWR19_RS08230	COG1028	Short-chain dehydrogenase reductase Sdr
BWR19_RS08235	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BWR19_RS08240	COG3395	kinase activity
BWR19_RS08245	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWR19_RS08255	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWR19_RS08260	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BWR19_RS08270	COG2721	sulfolactate sulfo-lyase activity
BWR19_RS08280	COG1028	Short-chain dehydrogenase reductase Sdr
BWR19_RS08300	COG1012	belongs to the aldehyde dehydrogenase family
BWR19_RS08310	COG3314	Sporulation integral membrane protein YlbJ
BWR19_RS08335	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BWR19_RS08355	COG1253	flavin adenine dinucleotide binding
BWR19_RS08390	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BWR19_RS08395	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BWR19_RS08400	COG0463	Glycosyl transferase, family 2
BWR19_RS08400	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BWR19_RS08425	COG0463	Glycosyl transferase, family 2
BWR19_RS08445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BWR19_RS08480	COG0028	Belongs to the TPP enzyme family
BWR19_RS08495	COG0436	Aminotransferase
BWR19_RS08525	COG3706	GGDEF domain
BWR19_RS08545	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWR19_RS08555	COG2186	Transcriptional regulator
BWR19_RS08560	COG0583	DNA-binding transcription factor activity
BWR19_RS08565	COG1012	belongs to the aldehyde dehydrogenase family
BWR19_RS08575	COG1473	amidohydrolase
BWR19_RS08620	COG0418	dihydroorotase activity
BWR19_RS08625	COG0697	spore germination
BWR19_RS08630	COG2807	transmembrane transport
BWR19_RS08650	COG1176	ABC-type spermidine putrescine transport system, permease component I
BWR19_RS08655	COG1177	transmembrane transport
BWR19_RS08695	COG1360	Flagellar Motor Protein
BWR19_RS08700	COG2198	Histidine kinase
BWR19_RS08700	COG0643	Histidine kinase
BWR19_RS08705	COG0835	chemotaxis
BWR19_RS08710	COG0840	transmembrane signaling receptor activity
BWR19_RS08715	COG0840	transmembrane signaling receptor activity
BWR19_RS08720	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BWR19_RS08725	COG2201	protein-glutamate methylesterase activity
BWR19_RS08730	COG0840	transmembrane signaling receptor activity
BWR19_RS08735	COG0745	RESPONSE REGULATOR receiver
BWR19_RS08750	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BWR19_RS08785	COG0513	Belongs to the DEAD box helicase family
BWR19_RS08800	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BWR19_RS08800	COG3008	intermembrane lipid transfer
BWR19_RS08805	COG2995	paraquat-inducible protein a
BWR19_RS08820	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BWR19_RS08825	COG3639	organic phosphonate transmembrane transporter activity
BWR19_RS08835	COG1271	oxidase subunit
BWR19_RS08840	COG1294	oxidase, subunit
BWR19_RS08845	COG4988	ABC transporter
BWR19_RS08850	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BWR19_RS08855	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BWR19_RS08870	COG0402	S-adenosylhomocysteine deaminase activity
BWR19_RS08880	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BWR19_RS08895	COG1309	transcriptional regulator
BWR19_RS08905	COG1643	Atp-dependent helicase
BWR19_RS08915	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BWR19_RS08935	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
BWR19_RS08940	COG0303	'Molybdopterin
BWR19_RS08945	COG0521	Mo-molybdopterin cofactor biosynthetic process
BWR19_RS08960	COG0437	4 iron, 4 sulfur cluster binding
BWR19_RS08965	COG3383	formate dehydrogenase (NAD+) activity
BWR19_RS08980	COG2878	Part of a membrane complex involved in electron transport
BWR19_RS08995	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BWR19_RS09015	COG0259	pyridoxamine-phosphate oxidase activity
BWR19_RS09040	COG2840	Smr protein MutS2
BWR19_RS09050	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BWR19_RS09055	COG2203	Gaf domain
BWR19_RS09055	COG3706	GGDEF domain
BWR19_RS09055	COG4251	negative regulation of phosphorylation
BWR19_RS09055	COG5001	Diguanylate cyclase
BWR19_RS09060	COG1879	ABC-type sugar transport system periplasmic component
BWR19_RS09065	COG0534	Mate efflux family protein
BWR19_RS09075	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BWR19_RS09075	COG0316	Belongs to the HesB IscA family
BWR19_RS09090	COG2166	iron-sulfur cluster assembly
BWR19_RS09100	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BWR19_RS09105	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BWR19_RS09110	COG0735	belongs to the Fur family
BWR19_RS09125	COG0189	ligase activity
BWR19_RS09125	COG4067	protein conserved in archaea
BWR19_RS09135	COG1917	Cupin 2, conserved barrel domain protein
BWR19_RS09140	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BWR19_RS09145	COG0456	acetyltransferase
BWR19_RS09155	COG0288	reversible hydration of carbon dioxide
BWR19_RS09160	COG0006	proline dipeptidase activity
BWR19_RS09165	COG0429	hydrolase of the alpha beta-hydrolase fold
BWR19_RS09170	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BWR19_RS09200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BWR19_RS09215	COG1028	Short-chain dehydrogenase reductase Sdr
BWR19_RS09225	COG2885	chlorophyll binding
BWR19_RS09230	COG0823	Involved in the tonB-independent uptake of proteins
BWR19_RS09250	COG0824	Thioesterase
BWR19_RS09255	COG2255	four-way junction helicase activity
BWR19_RS09260	COG0632	four-way junction helicase activity
BWR19_RS09265	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BWR19_RS09270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BWR19_RS09280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BWR19_RS09285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BWR19_RS09295	COG1254	Belongs to the acylphosphatase family
BWR19_RS09300	COG1295	ribonuclease BN
BWR19_RS09305	COG1051	belongs to the nudix hydrolase family
BWR19_RS09305	COG1056	cytidyltransferase-related domain
BWR19_RS09310	COG0583	DNA-binding transcription factor activity
BWR19_RS09315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BWR19_RS09325	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BWR19_RS09330	COG0556	nucleotide-excision repair
BWR19_RS09350	COG0084	hydrolase, TatD family'
BWR19_RS09355	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BWR19_RS09365	COG2205	protein histidine kinase activity
BWR19_RS09370	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BWR19_RS09395	COG0204	Acyl-transferase
BWR19_RS09410	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BWR19_RS09415	COG1115	amino acid carrier protein
BWR19_RS09420	COG0509	glycine decarboxylation via glycine cleavage system
BWR19_RS09430	COG0583	DNA-binding transcription factor activity
BWR19_RS09435	COG1611	Belongs to the LOG family
BWR19_RS09455	COG0776	regulation of translation
BWR19_RS09460	COG0072	phenylalanine-tRNA ligase activity
BWR19_RS09465	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BWR19_RS09470	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BWR19_RS09475	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BWR19_RS09480	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BWR19_RS09485	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BWR19_RS09500	COG0109	protoheme IX farnesyltransferase activity
BWR19_RS09505	COG1612	heme a metabolic process
BWR19_RS09525	COG1845	cytochrome c oxidase, subunit III
BWR19_RS09530	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BWR19_RS09535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BWR19_RS09540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BWR19_RS09555	COG1346	cytolysis
BWR19_RS09575	COG3263	regulation of cellular component size
BWR19_RS09580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BWR19_RS09590	COG0596	Alpha beta hydrolase
BWR19_RS09595	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BWR19_RS09605	COG0640	Transcriptional regulator
BWR19_RS09610	COG0616	signal peptide processing
BWR19_RS09630	COG0328	RNA-DNA hybrid ribonuclease activity
BWR19_RS09640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BWR19_RS09650	COG4166	transmembrane transport
BWR19_RS09655	COG4174	ABC transporter (Permease)
BWR19_RS09660	COG4239	(ABC) transporter, permease
BWR19_RS09665	COG4172	Belongs to the ABC transporter superfamily
BWR19_RS09670	COG1187	pseudouridine synthase activity
BWR19_RS09700	COG0747	negative chemotaxis
BWR19_RS09705	COG0601	transmembrane transport
BWR19_RS09710	COG0444	Belongs to the ABC transporter superfamily
BWR19_RS09715	COG4608	Belongs to the ABC transporter superfamily
BWR19_RS09720	COG2188	Transcriptional regulator
BWR19_RS09725	COG4993	Dehydrogenase
BWR19_RS09735	COG0659	secondary active sulfate transmembrane transporter activity
BWR19_RS09750	COG1024	Enoyl-CoA hydratase
BWR19_RS09755	COG1960	acyl-CoA dehydrogenase activity
BWR19_RS09760	COG1960	acyl-CoA dehydrogenase activity
BWR19_RS09780	COG0318	PFAM AMP-dependent synthetase and ligase
BWR19_RS09790	COG1250	3-hydroxyacyl-CoA dehydrogenase
BWR19_RS09795	COG0183	Belongs to the thiolase family
BWR19_RS09800	COG1414	Transcriptional regulator
BWR19_RS09805	COG1595	DNA-templated transcription, initiation
BWR19_RS09815	COG0579	oxidoreductase
BWR19_RS09820	COG1802	Transcriptional regulator
BWR19_RS09840	COG0022	dehydrogenase e1 component
BWR19_RS09845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BWR19_RS09850	COG1174	glycine betaine transport
BWR19_RS09855	COG1125	glycine betaine transport
BWR19_RS09860	COG1174	glycine betaine transport
BWR19_RS09865	COG1732	Glycine betaine
BWR19_RS09880	COG0215	cysteine-tRNA ligase activity
BWR19_RS09885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BWR19_RS09890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BWR19_RS09895	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BWR19_RS09900	COG0523	cobalamin synthesis protein
BWR19_RS09905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BWR19_RS09915	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BWR19_RS09920	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BWR19_RS09925	COG0740	serine-type endopeptidase activity
BWR19_RS09930	COG0544	peptidyl-prolyl cis-trans isomerase activity
BWR19_RS09955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BWR19_RS09960	COG1854	S-ribosylhomocysteine lyase activity
BWR19_RS09965	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BWR19_RS09970	COG1334	flagellar protein FlaG
BWR19_RS09975	COG0657	acetylesterase activity
BWR19_RS09980	COG0252	asparaginase activity
BWR19_RS09995	COG1766	The M ring may be actively involved in energy transduction
BWR19_RS10010	COG1157	protein secretion by the type III secretion system
BWR19_RS10025	COG1580	Controls the rotational direction of flagella during chemotaxis
BWR19_RS10030	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BWR19_RS10050	COG1987	bacterial-type flagellum assembly
BWR19_RS10070	COG3307	-O-antigen
BWR19_RS10085	COG4783	chaperone-mediated protein folding
BWR19_RS10100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BWR19_RS10120	COG0438	transferase activity, transferring glycosyl groups
BWR19_RS10140	COG0463	Glycosyl transferase, family 2
BWR19_RS10140	COG1216	Glycosyl transferase, family 2
BWR19_RS10145	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BWR19_RS10150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BWR19_RS10165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BWR19_RS10190	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BWR19_RS10195	COG5383	Protein conserved in bacteria
BWR19_RS10215	COG0583	DNA-binding transcription factor activity
BWR19_RS10220	COG0583	DNA-binding transcription factor activity
BWR19_RS10225	COG1012	belongs to the aldehyde dehydrogenase family
BWR19_RS10230	COG1757	Na H antiporter
BWR19_RS10235	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BWR19_RS10240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BWR19_RS10250	COG1705	Flagellar rod assembly protein muramidase FlgJ
BWR19_RS10250	COG3951	Flagellar rod assembly protein muramidase FlgJ
BWR19_RS10255	COG1706	bacterial-type flagellum-dependent cell motility
BWR19_RS10270	COG4787	bacterial-type flagellum-dependent cell motility
BWR19_RS10275	COG1749	Flagellar hook protein flgE
BWR19_RS10280	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BWR19_RS10285	COG1558	bacterial-type flagellum-dependent cell motility
BWR19_RS10290	COG1815	bacterial-type flagellum-dependent cell motility
BWR19_RS10300	COG2747	anti-sigma28 factor FlgM
BWR19_RS10305	COG3418	PFAM FlgN family protein
BWR19_RS10325	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BWR19_RS10330	COG0602	queuosine metabolic process
BWR19_RS10365	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BWR19_RS10370	COG5001	Diguanylate cyclase
BWR19_RS10380	COG0405	Gamma-glutamyltransferase
BWR19_RS10390	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BWR19_RS10400	COG1960	acyl-CoA dehydrogenase activity
BWR19_RS10405	COG1250	3-hydroxyacyl-CoA dehydrogenase
BWR19_RS10405	COG1024	Enoyl-CoA hydratase
BWR19_RS10415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BWR19_RS10435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BWR19_RS10440	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BWR19_RS10465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BWR19_RS10485	COG1763	Mo-molybdopterin cofactor biosynthetic process
BWR19_RS10490	COG0746	molybdenum cofactor guanylyltransferase activity
BWR19_RS10495	COG1396	sequence-specific DNA binding
BWR19_RS10495	COG1917	Cupin 2, conserved barrel domain protein
BWR19_RS10505	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BWR19_RS10510	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BWR19_RS10515	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BWR19_RS10520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BWR19_RS10525	COG2252	PERMEase
BWR19_RS10530	COG0307	riboflavin synthase, alpha
BWR19_RS10535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BWR19_RS10540	COG2011	ABC-type metal ion transport system permease component
BWR19_RS10545	COG1464	Belongs to the NlpA lipoprotein family
BWR19_RS10550	COG1956	GAF domain-containing protein
BWR19_RS10565	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BWR19_RS10600	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BWR19_RS10605	COG0628	permease
BWR19_RS10610	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BWR19_RS10615	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BWR19_RS10620	COG0717	Belongs to the dCTP deaminase family
BWR19_RS10625	COG0489	protein tyrosine kinase activity
BWR19_RS10660	COG0745	RESPONSE REGULATOR receiver
BWR19_RS10665	COG5002	protein histidine kinase activity
BWR19_RS10670	COG1295	ribonuclease BN
BWR19_RS10670	COG1959	2 iron, 2 sulfur cluster binding
BWR19_RS10690	COG3081	Nucleoid-associated protein
BWR19_RS10695	COG0842	Transport permease protein
BWR19_RS10700	COG1131	(ABC) transporter
BWR19_RS10710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BWR19_RS10745	COG0625	glutathione transferase activity
BWR19_RS10760	COG0417	DNA replication proofreading
BWR19_RS10765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BWR19_RS10765	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BWR19_RS10775	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BWR19_RS10785	COG0003	Pfam Anion-transporting ATPase
BWR19_RS10795	COG1966	Carbon starvation protein
BWR19_RS10805	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BWR19_RS10825	COG2176	DNA-directed DNA polymerase activity
BWR19_RS10825	COG5002	protein histidine kinase activity
BWR19_RS10835	COG5002	protein histidine kinase activity
BWR19_RS10850	COG0137	argininosuccinate synthase activity
BWR19_RS10855	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BWR19_RS10860	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BWR19_RS10865	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BWR19_RS10880	COG0322	excinuclease ABC activity
BWR19_RS10920	COG0776	regulation of translation
BWR19_RS10930	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BWR19_RS10935	COG0284	orotidine-5'-phosphate decarboxylase activity
BWR19_RS10955	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BWR19_RS10960	COG0459	protein refolding
BWR19_RS10965	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BWR19_RS10985	COG2423	ornithine cyclodeaminase activity
BWR19_RS10990	COG0251	oxidation-reduction process
BWR19_RS11000	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWR19_RS11010	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWR19_RS11015	COG4221	oxidoreductase activity
BWR19_RS11020	COG0583	DNA-binding transcription factor activity
BWR19_RS11025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BWR19_RS11030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BWR19_RS11035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BWR19_RS11045	COG0747	negative chemotaxis
BWR19_RS11050	COG0601	transmembrane transport
BWR19_RS11055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BWR19_RS11060	COG4172	Belongs to the ABC transporter superfamily
BWR19_RS11075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BWR19_RS11085	COG2610	gluconate transmembrane transporter activity
BWR19_RS11100	COG1122	ATPase activity
BWR19_RS11110	COG0583	DNA-binding transcription factor activity
BWR19_RS11120	COG1960	acyl-CoA dehydrogenase activity
BWR19_RS11125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BWR19_RS11170	COG1309	transcriptional regulator
BWR19_RS11175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BWR19_RS11185	COG3706	GGDEF domain
BWR19_RS11190	COG0625	glutathione transferase activity
BWR19_RS11195	COG1944	ATP diphosphatase activity
BWR19_RS11240	COG2207	Transcriptional regulator
BWR19_RS11240	COG1917	Cupin 2, conserved barrel domain protein
BWR19_RS11250	COG0840	transmembrane signaling receptor activity
BWR19_RS11255	COG5507	3-demethylubiquinone-9 3-methyltransferase
BWR19_RS11270	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BWR19_RS11275	COG0830	nickel cation binding
BWR19_RS11280	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
BWR19_RS11285	COG0804	urea catabolic process
BWR19_RS11290	COG0832	Belongs to the urease beta subunit family
BWR19_RS11295	COG0831	urea catabolic process
BWR19_RS11300	COG0829	nickel cation binding
BWR19_RS11330	COG1960	acyl-CoA dehydrogenase activity
BWR19_RS11350	COG4565	transcriptional regulatory protein
BWR19_RS11355	COG3290	protein histidine kinase activity
BWR19_RS11360	COG1648	precorrin-2 dehydrogenase activity
BWR19_RS11360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BWR19_RS11370	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BWR19_RS11380	COG0625	glutathione transferase activity
BWR19_RS11395	COG2828	Protein conserved in bacteria
BWR19_RS11400	COG0583	DNA-binding transcription factor activity
BWR19_RS11410	COG1279	arginine transmembrane transporter activity
BWR19_RS11425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BWR19_RS11455	COG0514	ATP-dependent DNA helicase (RecQ)
BWR19_RS11475	COG2154	pterin-4-alpha-carbinolamine dehydratase
BWR19_RS11490	COG0534	Mate efflux family protein
BWR19_RS11505	COG2353	YceI-like domain
BWR19_RS11510	COG3038	cytochrome b561
BWR19_RS11530	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BWR19_RS11535	COG1454	alcohol dehydrogenase
BWR19_RS11540	COG1609	Transcriptional regulator
BWR19_RS11545	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BWR19_RS11550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWR19_RS11560	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWR19_RS11605	COG1132	(ABC) transporter
BWR19_RS11610	COG2084	Dehydrogenase
BWR19_RS11615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BWR19_RS11635	COG3023	N-Acetylmuramoyl-L-alanine amidase
BWR19_RS11650	COG0442	prolyl-tRNA aminoacylation
BWR19_RS11655	COG0741	lytic transglycosylase activity
BWR19_RS11665	COG5001	Diguanylate cyclase
BWR19_RS11685	COG1047	Peptidyl-prolyl cis-trans
BWR19_RS11695	COG2211	Major facilitator Superfamily
BWR19_RS11700	COG0653	protein targeting
BWR19_RS11705	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BWR19_RS11710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BWR19_RS11720	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BWR19_RS11725	COG3956	TIGRFAM MazG family protein
BWR19_RS11730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BWR19_RS11735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BWR19_RS11745	COG0784	Response regulator, receiver
BWR19_RS11745	COG5002	protein histidine kinase activity
BWR19_RS11745	COG2205	protein histidine kinase activity
BWR19_RS11760	COG1381	Involved in DNA repair and RecF pathway recombination
BWR19_RS11765	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BWR19_RS11770	COG0571	ribonuclease III activity
BWR19_RS11780	COG0481	GTPase activity
BWR19_RS11795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BWR19_RS11815	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BWR19_RS11820	COG1199	ATP-dependent helicase activity
BWR19_RS11825	COG0513	Belongs to the DEAD box helicase family
BWR19_RS11845	COG0848	biopolymer transport protein
BWR19_RS11850	COG0811	peptide transport
BWR19_RS11855	COG0811	peptide transport
BWR19_RS11865	COG1120	ATPase activity
BWR19_RS11870	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BWR19_RS11875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BWR19_RS11880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BWR19_RS11885	COG0583	DNA-binding transcription factor activity
BWR19_RS11890	COG4771	TonB-dependent receptor
BWR19_RS11925	COG0210	DNA helicase
BWR19_RS11935	COG0084	hydrolase, TatD family'
BWR19_RS11950	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BWR19_RS11955	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BWR19_RS11960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BWR19_RS11965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BWR19_RS11970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BWR19_RS11980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BWR19_RS11985	COG0416	fatty acid biosynthetic process
BWR19_RS11990	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BWR19_RS11995	COG1399	metal-binding, possibly nucleic acid-binding protein
BWR19_RS12000	COG0424	maF-like protein
BWR19_RS12015	COG0564	pseudouridine synthase activity
BWR19_RS12020	COG1530	ribonuclease E activity
BWR19_RS12025	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BWR19_RS12030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BWR19_RS12035	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BWR19_RS12040	COG2835	tetraacyldisaccharide 4'-kinase activity
BWR19_RS12050	COG1132	(ABC) transporter
BWR19_RS12055	COG0848	biopolymer transport protein
BWR19_RS12060	COG0811	peptide transport
BWR19_RS12065	COG2333	competence protein COMEC
BWR19_RS12065	COG0658	competence protein
BWR19_RS12075	COG1136	(ABC) transporter
BWR19_RS12080	COG4591	ABC-type transport system involved in lipoprotein release permease component
BWR19_RS12085	COG2957	Belongs to the agmatine deiminase family
BWR19_RS12090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BWR19_RS12095	COG0352	thiamine-phosphate diphosphorylase activity
BWR19_RS12100	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BWR19_RS12105	COG0653	protein targeting
BWR19_RS12120	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BWR19_RS12140	COG1181	Belongs to the D-alanine--D-alanine ligase family
BWR19_RS12145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BWR19_RS12150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BWR19_RS12155	COG0772	Belongs to the SEDS family
BWR19_RS12160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BWR19_RS12165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BWR19_RS12170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BWR19_RS12185	COG3116	cell division
BWR19_RS12190	COG0275	rRNA processing
BWR19_RS12205	COG3107	peptidoglycan biosynthetic process
BWR19_RS12210	COG0792	nuclease activity
BWR19_RS12215	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BWR19_RS12220	COG2823	Periplasmic or secreted lipoprotein
BWR19_RS12225	COG2969	positive regulation of protein catabolic process
BWR19_RS12230	COG0625	glutathione transferase activity
BWR19_RS12235	COG2857	Cytochrome c1
BWR19_RS12240	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BWR19_RS12245	COG0723	plastoquinol--plastocyanin reductase activity
BWR19_RS12250	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BWR19_RS12255	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BWR19_RS12260	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BWR19_RS12275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BWR19_RS12285	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BWR19_RS12290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BWR19_RS12295	COG5007	Belongs to the BolA IbaG family
BWR19_RS12310	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BWR19_RS12315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BWR19_RS12320	COG1127	ABC transporter
BWR19_RS12325	COG0530	calcium, potassium:sodium antiporter activity
BWR19_RS12345	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BWR19_RS12350	COG1137	ATPase activity
BWR19_RS12370	COG1660	Displays ATPase and GTPase activities
BWR19_RS12380	COG0312	modulator of DNA gyrase
BWR19_RS12385	COG3028	Belongs to the UPF0307 family
BWR19_RS12390	COG0312	modulator of DNA gyrase
BWR19_RS12400	COG1530	ribonuclease E activity
BWR19_RS12405	COG0424	maF-like protein
BWR19_RS12410	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BWR19_RS12415	COG1792	Involved in formation and maintenance of cell shape
BWR19_RS12420	COG1077	Cell shape determining protein MreB Mrl
BWR19_RS12425	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BWR19_RS12430	COG0154	amidase activity
BWR19_RS12435	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BWR19_RS12445	COG2197	response regulator
BWR19_RS12465	COG1322	Protein conserved in bacteria
BWR19_RS12470	COG1012	belongs to the aldehyde dehydrogenase family
BWR19_RS12480	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BWR19_RS12485	COG0174	glutamine synthetase
BWR19_RS12495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BWR19_RS12500	COG1177	transmembrane transport
BWR19_RS12505	COG1176	ABC-type spermidine putrescine transport system, permease component I
BWR19_RS12510	COG3842	ATPase activity
BWR19_RS12520	COG0174	glutamine synthetase
BWR19_RS12525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BWR19_RS12540	COG2890	protein-(glutamine-N5) methyltransferase activity
BWR19_RS12545	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BWR19_RS12550	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BWR19_RS12560	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BWR19_RS12565	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BWR19_RS12580	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BWR19_RS12585	COG0193	aminoacyl-tRNA hydrolase activity
BWR19_RS12590	COG0012	GTP binding
BWR19_RS12605	COG0583	DNA-binding transcription factor activity
BWR19_RS12610	COG1362	aminopeptidase activity
BWR19_RS12620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BWR19_RS12625	COG4941	Belongs to the sigma-70 factor family
BWR19_RS12630	COG3795	YCII-related domain
BWR19_RS12675	COG2764	glyoxalase bleomycin resistance protein dioxygenase
BWR19_RS12705	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BWR19_RS12710	COG0384	phenazine biosynthesis protein PhzF
BWR19_RS12735	COG0583	DNA-binding transcription factor activity
BWR19_RS12750	COG1280	lysine exporter protein (LysE YggA)
BWR19_RS12755	COG1846	Transcriptional regulator
BWR19_RS12770	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BWR19_RS12780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BWR19_RS12785	COG0640	Transcriptional regulator
BWR19_RS12805	COG0604	alcohol dehydrogenase
BWR19_RS12820	COG1132	(ABC) transporter
BWR19_RS12835	COG2828	Protein conserved in bacteria
BWR19_RS12845	COG0372	Belongs to the citrate synthase family
BWR19_RS12850	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BWR19_RS12855	COG1802	Transcriptional regulator
BWR19_RS12865	COG0175	sulfate reduction
BWR19_RS12875	COG3118	belongs to the thioredoxin family
BWR19_RS12880	COG0628	permease
BWR19_RS12890	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BWR19_RS12895	COG0247	lactate metabolic process
BWR19_RS12895	COG0277	FAD linked oxidase domain protein
BWR19_RS12900	COG5002	protein histidine kinase activity
BWR19_RS12915	COG2161	toxin-antitoxin pair type II binding
BWR19_RS12965	COG0134	indole-3-glycerol-phosphate synthase activity
BWR19_RS12970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BWR19_RS12975	COG0512	Glutamine amidotransferase of anthranilate synthase
BWR19_RS12980	COG3549	Plasmid maintenance system killer
BWR19_RS13020	COG3501	Rhs element vgr protein
BWR19_RS13040	COG1252	NADH dehydrogenase
BWR19_RS13045	COG2827	Endonuclease containing a URI domain
BWR19_RS13050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BWR19_RS13060	COG4150	thiosulfate binding
BWR19_RS13070	COG4208	sulfate ABC transporter
BWR19_RS13075	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BWR19_RS13085	COG0500	methyltransferase
BWR19_RS13090	COG4991	sh3 domain protein
BWR19_RS13100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BWR19_RS13105	COG1702	phosphate starvation-inducible protein PhoH
BWR19_RS13110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BWR19_RS13125	COG3243	poly(R)-hydroxyalkanoic acid synthase
BWR19_RS13140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BWR19_RS13160	COG0596	Alpha beta hydrolase
BWR19_RS13180	COG2186	Transcriptional regulator
BWR19_RS13205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BWR19_RS13210	COG2062	phosphohistidine phosphatase, SixA
BWR19_RS13215	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BWR19_RS13220	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BWR19_RS13230	COG1335	isochorismatase
BWR19_RS13235	COG0326	Molecular chaperone. Has ATPase activity
BWR19_RS13250	COG0741	lytic transglycosylase activity
BWR19_RS13255	COG1280	lysine exporter protein (LysE YggA)
BWR19_RS13260	COG1278	Cold shock
BWR19_RS13270	COG1597	lipid kinase activity
BWR19_RS13275	COG0501	Belongs to the peptidase M48B family
BWR19_RS13280	COG1704	LemA family
BWR19_RS13290	COG0308	aminopeptidase N
BWR19_RS13295	COG2832	Protein of unknown function (DUF454)
BWR19_RS13300	COG3384	dioxygenase
BWR19_RS13305	COG0071	Belongs to the small heat shock protein (HSP20) family
BWR19_RS13310	COG3344	reverse transcriptase
BWR19_RS13315	COG1960	acyl-CoA dehydrogenase activity
BWR19_RS13320	COG1309	transcriptional regulator
BWR19_RS13325	COG0183	Belongs to the thiolase family
BWR19_RS13330	COG0798	PFAM Bile acid sodium symporter
BWR19_RS13345	COG0640	Transcriptional regulator
BWR19_RS13355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BWR19_RS13360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BWR19_RS13365	COG0581	inorganic phosphate transmembrane transporter activity
BWR19_RS13370	COG0573	inorganic phosphate transmembrane transporter activity
BWR19_RS13385	COG2814	Major facilitator Superfamily
BWR19_RS13390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BWR19_RS13415	COG1643	Atp-dependent helicase
BWR19_RS13420	COG0318	PFAM AMP-dependent synthetase and ligase
BWR19_RS13425	COG0121	glutamine amidotransferase
BWR19_RS13445	COG2983	Belongs to the UPF0260 family
BWR19_RS13450	COG3100	YcgL domain-containing protein
BWR19_RS13460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BWR19_RS13465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BWR19_RS13470	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BWR19_RS13490	COG3180	Ammonia monooxygenase
BWR19_RS13495	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BWR19_RS13510	COG1335	isochorismatase
BWR19_RS13520	COG1196	nuclear chromosome segregation
BWR19_RS13520	COG3264	Mechanosensitive ion channel
BWR19_RS13530	COG4575	ribosome binding
BWR19_RS13535	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
BWR19_RS13545	COG2081	HI0933 family
BWR19_RS13560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BWR19_RS13575	COG0569	domain protein
BWR19_RS13580	COG0745	RESPONSE REGULATOR receiver
BWR19_RS13585	COG2205	protein histidine kinase activity
BWR19_RS13590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BWR19_RS13600	COG1595	DNA-templated transcription, initiation
BWR19_RS13645	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BWR19_RS13650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BWR19_RS13665	COG2217	Heavy metal translocating P-type atpase
BWR19_RS13690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BWR19_RS13690	COG0189	ligase activity
BWR19_RS13695	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BWR19_RS13725	COG2323	membrane
BWR19_RS13740	COG0628	permease
BWR19_RS13760	COG3300	MHYT domain
BWR19_RS13760	COG5001	Diguanylate cyclase
BWR19_RS13765	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BWR19_RS13765	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BWR19_RS13765	COG0506	proline dehydrogenase activity
BWR19_RS13770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BWR19_RS13785	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BWR19_RS13785	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BWR19_RS13790	COG0842	Transport permease protein
BWR19_RS13795	COG1131	(ABC) transporter
BWR19_RS13830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BWR19_RS13835	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BWR19_RS13840	COG0436	Aminotransferase
BWR19_RS13845	COG0501	Belongs to the peptidase M48B family
BWR19_RS13850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BWR19_RS13865	COG0116	Belongs to the methyltransferase superfamily
BWR19_RS13865	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BWR19_RS13870	COG3130	regulation of translation
BWR19_RS13875	COG0167	dihydroorotate dehydrogenase activity
BWR19_RS13880	COG2902	Dehydrogenase
BWR19_RS13885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BWR19_RS13890	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BWR19_RS13895	COG0583	DNA-binding transcription factor activity
BWR19_RS13900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BWR19_RS13905	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BWR19_RS13915	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BWR19_RS13920	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BWR19_RS13925	COG1674	ftsk spoiiie
BWR19_RS13930	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BWR19_RS13935	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BWR19_RS13940	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BWR19_RS13945	COG0542	response to heat
BWR19_RS13950	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BWR19_RS13960	COG1187	pseudouridine synthase activity
BWR19_RS13985	COG0482	sulfurtransferase activity
BWR19_RS13990	COG2915	High frequency lysogenization protein hflD homolog
BWR19_RS14000	COG2850	peptidyl-arginine hydroxylation
BWR19_RS14025	COG1047	Peptidyl-prolyl cis-trans
BWR19_RS14035	COG0747	negative chemotaxis
BWR19_RS14040	COG0601	transmembrane transport
BWR19_RS14045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BWR19_RS14050	COG0444	Belongs to the ABC transporter superfamily
BWR19_RS14060	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BWR19_RS14065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BWR19_RS14070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BWR19_RS14075	COG2814	Major facilitator Superfamily
BWR19_RS14080	COG0583	DNA-binding transcription factor activity
BWR19_RS14085	COG0791	NLP P60 protein
BWR19_RS14095	COG1012	belongs to the aldehyde dehydrogenase family
BWR19_RS14100	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BWR19_RS14130	COG2814	Major facilitator Superfamily
BWR19_RS14135	COG3106	COG3106 Predicted ATPase
BWR19_RS14140	COG3768	UPF0283 membrane protein
BWR19_RS14145	COG0589	response to stress
BWR19_RS14155	COG0702	epimerase
BWR19_RS14180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BWR19_RS14215	COG1053	succinate dehydrogenase
BWR19_RS14220	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BWR19_RS14245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BWR19_RS14255	COG0583	DNA-binding transcription factor activity
BWR19_RS14260	COG3344	reverse transcriptase
BWR19_RS14280	COG1737	Transcriptional regulator
BWR19_RS14310	COG0589	response to stress
BWR19_RS14325	COG3284	Transcriptional regulator
BWR19_RS14335	COG0346	lactoylglutathione lyase activity
BWR19_RS14340	COG1250	3-hydroxyacyl-CoA dehydrogenase
BWR19_RS14345	COG0601	transmembrane transport
BWR19_RS14350	COG0747	negative chemotaxis
BWR19_RS14355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BWR19_RS14365	COG0444	Belongs to the ABC transporter superfamily
BWR19_RS14370	COG1064	alcohol dehydrogenase
BWR19_RS14375	COG0589	response to stress
BWR19_RS14385	COG0659	secondary active sulfate transmembrane transporter activity
BWR19_RS14395	COG1030	water channel activity
BWR19_RS14410	COG4134	Bacterial extracellular solute-binding protein
BWR19_RS14415	COG4135	transport system, permease component
BWR19_RS14420	COG4136	ATPase activity
BWR19_RS14445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BWR19_RS14450	COG1012	belongs to the aldehyde dehydrogenase family
BWR19_RS14475	COG1522	sequence-specific DNA binding
BWR19_RS14480	COG3608	succinylglutamate desuccinylase aspartoacylase
BWR19_RS14485	COG0006	proline dipeptidase activity
BWR19_RS14495	COG1335	isochorismatase
BWR19_RS14510	COG2431	L-lysine efflux transmembrane transporter activity
BWR19_RS14520	COG1653	transport
BWR19_RS14535	COG0366	Alpha amylase catalytic
BWR19_RS14540	COG3842	ATPase activity
BWR19_RS14545	COG1609	Transcriptional regulator
BWR19_RS14550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWR19_RS14555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BWR19_RS14560	COG2205	protein histidine kinase activity
BWR19_RS14565	COG0745	RESPONSE REGULATOR receiver
BWR19_RS14575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BWR19_RS14580	COG1376	ErfK ybiS ycfS ynhG family protein
BWR19_RS14595	COG2133	pyrroloquinoline quinone binding
BWR19_RS14600	COG2205	protein histidine kinase activity
BWR19_RS14600	COG0784	Response regulator, receiver
BWR19_RS14620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BWR19_RS14620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BWR19_RS14620	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
BWR19_RS14625	COG1105	Belongs to the carbohydrate kinase PfkB family
BWR19_RS14635	COG1609	Transcriptional regulator
BWR19_RS14685	COG2863	cytochrome
BWR19_RS14690	COG0446	pyridine nucleotide-disulphide oxidoreductase
BWR19_RS14720	COG1509	lysine 2,3-aminomutase activity
BWR19_RS14730	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWR19_RS14740	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWR19_RS14750	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BWR19_RS14765	COG1116	anion transmembrane transporter activity
BWR19_RS14770	COG0390	transport system, permease component
BWR19_RS14790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BWR19_RS14795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BWR19_RS14805	COG1620	l-lactate permease
BWR19_RS14810	COG4948	Mandelate Racemase Muconate Lactonizing
BWR19_RS14815	COG0247	lactate metabolic process
BWR19_RS14815	COG0277	FAD linked oxidase domain protein
BWR19_RS14825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BWR19_RS14830	COG1024	Enoyl-CoA hydratase
BWR19_RS14835	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWR19_RS14835	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BWR19_RS14845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWR19_RS14850	COG1802	Transcriptional regulator
BWR19_RS14855	COG2186	Transcriptional regulator
BWR19_RS14860	COG0277	FAD linked oxidase domain protein
BWR19_RS14865	COG0277	FAD linked oxidase domain protein
BWR19_RS14870	COG0247	lactate metabolic process
BWR19_RS14875	COG3193	protein, possibly involved in utilization of glycolate and propanediol
BWR19_RS14880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BWR19_RS14885	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BWR19_RS14890	COG0697	spore germination
BWR19_RS14900	COG3706	GGDEF domain
BWR19_RS14900	COG2203	Gaf domain
BWR19_RS14900	COG5001	Diguanylate cyclase
BWR19_RS14900	COG4251	negative regulation of phosphorylation
BWR19_RS14905	COG0395	ABC-type sugar transport system, permease component
BWR19_RS14915	COG1653	transport
BWR19_RS14925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BWR19_RS14925	COG3153	acetyltransferase
BWR19_RS14935	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
BWR19_RS14940	COG2084	Dehydrogenase
BWR19_RS14955	COG2175	clavaminate synthase activity
BWR19_RS14965	COG0583	DNA-binding transcription factor activity
BWR19_RS14970	COG0596	Alpha beta hydrolase
BWR19_RS14975	COG0473	3-isopropylmalate dehydrogenase activity
BWR19_RS14980	COG0655	NAD(P)H dehydrogenase (quinone) activity
BWR19_RS14995	COG2988	succinylglutamate desuccinylase activity
BWR19_RS15010	COG4160	amino acid transport
BWR19_RS15015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BWR19_RS15020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BWR19_RS15030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BWR19_RS15040	COG0519	Catalyzes the synthesis of GMP from XMP
BWR19_RS15050	COG1012	belongs to the aldehyde dehydrogenase family
BWR19_RS15055	COG0174	glutamine synthetase
BWR19_RS15115	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BWR19_RS15150	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BWR19_RS15155	COG0709	Synthesizes selenophosphate from selenide and ATP
BWR19_RS15165	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BWR19_RS15170	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BWR19_RS15180	COG3639	organic phosphonate transmembrane transporter activity
BWR19_RS15185	COG0129	dihydroxy-acid dehydratase activity
BWR19_RS15205	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BWR19_RS15215	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWR19_RS15225	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWR19_RS15250	COG0154	amidase activity
BWR19_RS15260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BWR19_RS15265	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BWR19_RS15270	COG1074	ATP-dependent DNA helicase activity
BWR19_RS15275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BWR19_RS15355	COG5654	RES domain protein
BWR19_RS15370	COG0488	(ABC) transporter
BWR19_RS15390	COG2032	superoxide dismutase activity
BWR19_RS15450	COG4948	Mandelate Racemase Muconate Lactonizing
BWR19_RS15455	COG0583	DNA-binding transcription factor activity
BWR19_RS15460	COG2193	ferroxidase activity
BWR19_RS15515	COG0583	DNA-binding transcription factor activity
BWR19_RS15535	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWR19_RS15555	COG1902	pentaerythritol trinitrate reductase activity
BWR19_RS15575	COG0723	plastoquinol--plastocyanin reductase activity
BWR19_RS15575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BWR19_RS15585	COG3938	Belongs to the proline racemase family
BWR19_RS15590	COG1063	alcohol dehydrogenase
BWR19_RS15605	COG2203	Gaf domain
BWR19_RS15605	COG3706	GGDEF domain
BWR19_RS15605	COG4251	negative regulation of phosphorylation
BWR19_RS15605	COG5001	Diguanylate cyclase
BWR19_RS15610	COG0598	Magnesium transport protein CorA
BWR19_RS15620	COG0840	transmembrane signaling receptor activity
BWR19_RS15660	COG2909	trisaccharide binding
BWR19_RS15665	COG0366	Alpha amylase catalytic
BWR19_RS15680	COG2182	Extracellular solute-binding protein
BWR19_RS15695	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BWR19_RS15710	COG3724	N-succinylarginine dihydrolase activity
BWR19_RS15715	COG1012	belongs to the aldehyde dehydrogenase family
BWR19_RS15735	COG2226	methyltransferase
BWR19_RS15755	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BWR19_RS15765	COG0386	Belongs to the glutathione peroxidase family
BWR19_RS15780	COG0714	Associated with various cellular activities
BWR19_RS15790	COG1960	acyl-CoA dehydrogenase activity
BWR19_RS15805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BWR19_RS15835	COG2249	NAD(P)H dehydrogenase (quinone) activity
BWR19_RS15910	COG4983	Phage plasmid primase, P4 family domain protein
BWR19_RS15960	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BWR19_RS15965	COG0343	queuine tRNA-ribosyltransferase activity
BWR19_RS15970	COG1862	Preprotein translocase
BWR19_RS16005	COG1104	cysteine desulfurase activity
BWR19_RS16015	COG0105	UTP biosynthetic process
BWR19_RS16020	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BWR19_RS16035	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BWR19_RS16040	COG0124	histidyl-tRNA synthetase
BWR19_RS16045	COG2976	Protein conserved in bacteria
BWR19_RS16055	COG1160	GTP binding
BWR19_RS16060	COG2133	pyrroloquinoline quinone binding
BWR19_RS16080	COG0501	Belongs to the peptidase M48B family
BWR19_RS16095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BWR19_RS16100	COG0601	transmembrane transport
BWR19_RS16110	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BWR19_RS16115	COG0408	coproporphyrinogen oxidase activity
BWR19_RS16120	COG0009	L-threonylcarbamoyladenylate synthase
BWR19_RS16125	COG0758	DNA mediated transformation
BWR19_RS16130	COG1652	LysM domain
BWR19_RS16135	COG0242	peptide deformylase activity
BWR19_RS16140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BWR19_RS16150	COG3360	Dodecin
BWR19_RS16155	COG0569	domain protein
BWR19_RS16160	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BWR19_RS16170	COG3148	PFAM DTW domain containing protein
BWR19_RS16180	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BWR19_RS16190	COG0402	S-adenosylhomocysteine deaminase activity
BWR19_RS16230	COG0402	S-adenosylhomocysteine deaminase activity
BWR19_RS16235	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BWR19_RS16245	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWR19_RS16260	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BWR19_RS16270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BWR19_RS16275	COG1116	anion transmembrane transporter activity
BWR19_RS16300	COG0795	lipopolysaccharide-transporting ATPase activity
BWR19_RS16305	COG0795	lipopolysaccharide-transporting ATPase activity
BWR19_RS16310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BWR19_RS16315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BWR19_RS16325	COG0525	valine-tRNA ligase activity
BWR19_RS16335	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BWR19_RS16350	COG1028	Short-chain dehydrogenase reductase Sdr
BWR19_RS16355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BWR19_RS16360	COG0671	phosphoesterase, PA-phosphatase related
BWR19_RS16375	COG0346	lactoylglutathione lyase activity
BWR19_RS16385	COG0519	Catalyzes the synthesis of GMP from XMP
BWR19_RS16400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BWR19_RS16405	COG0583	DNA-binding transcription factor activity
BWR19_RS16410	COG2205	protein histidine kinase activity
BWR19_RS16415	COG0745	RESPONSE REGULATOR receiver
BWR19_RS16420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BWR19_RS16420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BWR19_RS16425	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BWR19_RS16450	COG1199	ATP-dependent helicase activity
BWR19_RS16460	COG1295	ribonuclease BN
BWR19_RS16465	COG3577	Aspartyl protease
BWR19_RS16470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BWR19_RS16495	COG3706	GGDEF domain
BWR19_RS16535	COG1757	Na H antiporter
BWR19_RS16540	COG2957	Belongs to the agmatine deiminase family
BWR19_RS16545	COG1757	Na H antiporter
BWR19_RS16555	COG2197	response regulator
BWR19_RS16570	COG2358	TRAP transporter, solute receptor (TAXI family
BWR19_RS16575	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BWR19_RS16605	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BWR19_RS16620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BWR19_RS16655	COG1131	(ABC) transporter
BWR19_RS16700	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
BWR19_RS16710	COG0535	radical SAM domain protein
BWR19_RS16715	COG1025	Belongs to the peptidase M16 family
BWR19_RS16720	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BWR19_RS16725	COG3791	Glutathione-dependent formaldehyde-activating
BWR19_RS16735	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BWR19_RS16770	COG1024	Enoyl-CoA hydratase
BWR19_RS16800	COG3706	GGDEF domain
BWR19_RS16810	COG0183	Belongs to the thiolase family
BWR19_RS16820	COG3005	denitrification pathway
BWR19_RS16830	COG0243	molybdopterin cofactor binding
BWR19_RS16845	COG4459	periplasmic nitrate reductase
BWR19_RS16850	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BWR19_RS16860	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BWR19_RS16875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BWR19_RS16885	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BWR19_RS16890	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BWR19_RS16895	COG0534	Mate efflux family protein
BWR19_RS16900	COG2031	fatty acid transporter
BWR19_RS16905	COG1607	acyl-coa hydrolase
BWR19_RS16915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BWR19_RS16965	COG1929	Belongs to the glycerate kinase type-1 family
BWR19_RS16970	COG0783	Belongs to the Dps family
BWR19_RS16975	COG2195	Cleaves the N-terminal amino acid of tripeptides
BWR19_RS16980	COG1444	tRNA N-acetyltransferase activity
BWR19_RS16985	COG1840	ABC-type Fe3 transport system, periplasmic component
BWR19_RS16990	COG1178	ABC-type Fe3 transport system permease component
BWR19_RS16995	COG3842	ATPase activity
BWR19_RS17015	COG1166	arginine decarboxylase activity
BWR19_RS17020	COG0179	Fumarylacetoacetate (FAA) hydrolase
BWR19_RS17025	COG5285	phytanoyl-CoA dioxygenase
BWR19_RS17030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BWR19_RS17060	COG2963	transposase activity
BWR19_RS17065	COG2801	Transposase and inactivated derivatives
BWR19_RS17075	COG2801	Transposase and inactivated derivatives
BWR19_RS17125	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BWR19_RS17130	COG1194	a g-specific adenine glycosylase
BWR19_RS17145	COG0131	Imidazoleglycerol-phosphate dehydratase
BWR19_RS17150	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BWR19_RS17155	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BWR19_RS17160	COG0107	imidazoleglycerol-phosphate synthase activity
BWR19_RS17170	COG3068	Protein conserved in bacteria
BWR19_RS17185	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BWR19_RS17190	COG0709	Synthesizes selenophosphate from selenide and ATP
BWR19_RS17195	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BWR19_RS17205	COG1902	pentaerythritol trinitrate reductase activity
BWR19_RS17215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BWR19_RS17245	COG1183	phosphatidylcholine synthase activity
BWR19_RS17250	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BWR19_RS17260	COG0440	acetolactate synthase activity
BWR19_RS17265	COG0028	Belongs to the TPP enzyme family
BWR19_RS17290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BWR19_RS17290	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BWR19_RS17300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BWR19_RS17305	COG4969	Belongs to the N-Me-Phe pilin family
BWR19_RS17315	COG4966	pilus assembly protein PilW
BWR19_RS17335	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BWR19_RS17340	COG1047	Peptidyl-prolyl cis-trans
BWR19_RS17350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BWR19_RS17355	COG0196	riboflavin kinase activity
BWR19_RS17365	COG0268	Binds directly to 16S ribosomal RNA
BWR19_RS17370	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BWR19_RS17375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BWR19_RS17380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BWR19_RS17385	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BWR19_RS17390	COG0142	geranyltranstransferase activity
BWR19_RS17415	COG2223	nitrite transmembrane transporter activity
BWR19_RS17430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BWR19_RS17435	COG1090	epimerase
BWR19_RS17440	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BWR19_RS17445	COG0789	Transcriptional regulator
BWR19_RS17450	COG0415	Belongs to the DNA photolyase family
BWR19_RS17460	COG0300	oxidoreductase activity
BWR19_RS17465	COG1233	COG1233 Phytoene dehydrogenase and related
BWR19_RS17475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BWR19_RS17490	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BWR19_RS17510	COG0629	single-stranded DNA binding
BWR19_RS17515	COG2814	Major facilitator Superfamily
BWR19_RS17525	COG0203	ribosomal protein L17
BWR19_RS17530	COG0202	RNA polymerase activity
BWR19_RS17535	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BWR19_RS17540	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BWR19_RS17545	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BWR19_RS17550	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BWR19_RS17560	COG0200	Binds to the 23S rRNA
BWR19_RS17565	COG1841	ribosomal large subunit assembly
BWR19_RS17570	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BWR19_RS17575	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BWR19_RS17580	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BWR19_RS17585	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BWR19_RS17590	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BWR19_RS17595	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BWR19_RS17600	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BWR19_RS17605	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BWR19_RS17610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BWR19_RS17615	COG0255	Belongs to the universal ribosomal protein uL29 family
BWR19_RS17620	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BWR19_RS17625	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BWR19_RS17630	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BWR19_RS17635	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BWR19_RS17640	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BWR19_RS17645	COG0089	rRNA binding
BWR19_RS17650	COG0088	Forms part of the polypeptide exit tunnel
BWR19_RS17655	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BWR19_RS17660	COG0051	transcription antitermination factor activity, RNA binding
BWR19_RS17665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BWR19_RS17670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BWR19_RS17675	COG0049	tRNA binding
BWR19_RS17680	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BWR19_RS17685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BWR19_RS17690	COG0085	RNA polymerase activity
BWR19_RS17695	COG0222	ribosome binding
BWR19_RS17700	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BWR19_RS17705	COG0081	regulation of translation
BWR19_RS17710	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BWR19_RS17745	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BWR19_RS17790	COG1139	Iron-sulfur cluster binding protein
BWR19_RS17795	COG0247	lactate metabolic process
BWR19_RS17800	COG2186	Transcriptional regulator
BWR19_RS17820	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BWR19_RS17825	COG0733	neurotransmitter:sodium symporter activity
BWR19_RS17850	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BWR19_RS17865	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BWR19_RS17870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BWR19_RS17875	COG1830	Aldolase
BWR19_RS17880	COG0071	Belongs to the small heat shock protein (HSP20) family
BWR19_RS17895	COG1346	cytolysis
BWR19_RS17900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BWR19_RS17905	COG0126	phosphoglycerate kinase activity
BWR19_RS17920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BWR19_RS17945	COG0023	Translation Initiation Factor
BWR19_RS17980	COG2204	response regulator
BWR19_RS18025	COG1228	amidohydrolase
BWR19_RS18040	COG1063	alcohol dehydrogenase
BWR19_RS18055	COG0733	neurotransmitter:sodium symporter activity
BWR19_RS18105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BWR19_RS18110	COG1518	maintenance of DNA repeat elements
BWR19_RS18125	COG1857	crispr-associated protein
BWR19_RS18140	COG1203	CRISPR-associated helicase, Cas3
BWR19_RS18150	COG0584	glycerophosphoryl diester phosphodiesterase
BWR19_RS18160	COG1283	sodium-dependent phosphate transmembrane transporter activity
BWR19_RS18165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BWR19_RS18175	COG1121	(ABC) transporter
BWR19_RS18180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BWR19_RS18185	COG0803	Belongs to the bacterial solute-binding protein 9 family
BWR19_RS18190	COG4181	ATPase activity
BWR19_RS18195	COG0577	efflux transmembrane transporter activity
BWR19_RS18225	COG0791	NLP P60 protein
BWR19_RS18230	COG1321	iron dependent repressor
BWR19_RS18240	COG1121	(ABC) transporter
BWR19_RS18245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BWR19_RS18250	COG0697	spore germination
BWR19_RS18260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BWR19_RS18270	COG1686	Belongs to the peptidase S11 family
BWR19_RS18285	COG0840	transmembrane signaling receptor activity
BWR19_RS18305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BWR19_RS18310	COG0583	DNA-binding transcription factor activity
BWR19_RS18315	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BWR19_RS18320	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BWR19_RS18325	COG1984	allophanate hydrolase subunit 2
BWR19_RS18330	COG0411	ABC transporter
BWR19_RS18360	COG5564	TIM-barrel signal transduction protein
BWR19_RS18370	COG5441	Belongs to the UPF0261 family
BWR19_RS18375	COG5564	TIM-barrel signal transduction protein
BWR19_RS18380	COG0559	Belongs to the binding-protein-dependent transport system permease family
BWR19_RS18405	COG3530	Putative quorum-sensing-regulated virulence factor
BWR19_RS18410	COG0730	response to heat
BWR19_RS18425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BWR19_RS18450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BWR19_RS18465	COG0583	DNA-binding transcription factor activity
BWR19_RS18480	COG0210	DNA helicase
BWR19_RS18485	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BWR19_RS18495	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BWR19_RS18500	COG0708	Exodeoxyribonuclease III
BWR19_RS18505	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BWR19_RS18510	COG1561	YicC-like family, N-terminal region
BWR19_RS18515	COG4191	Histidine kinase
BWR19_RS18520	COG1100	Small GTP-binding protein
BWR19_RS18525	COG2204	response regulator
BWR19_RS18585	COG0194	GDP metabolic process
BWR19_RS18590	COG1758	RNA polymerase activity
BWR19_RS18595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BWR19_RS18615	COG0583	DNA-binding transcription factor activity
BWR19_RS18620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BWR19_RS18625	COG1289	transmembrane transporter activity
BWR19_RS18640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BWR19_RS18645	COG3161	chorismate lyase activity
BWR19_RS18650	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BWR19_RS18665	COG4166	transmembrane transport
BWR19_RS18670	COG0601	transmembrane transport
BWR19_RS18675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BWR19_RS18680	COG0444	Belongs to the ABC transporter superfamily
BWR19_RS18685	COG4608	Belongs to the ABC transporter superfamily
BWR19_RS18700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BWR19_RS18705	COG0573	inorganic phosphate transmembrane transporter activity
BWR19_RS18710	COG0573	inorganic phosphate transmembrane transporter activity
BWR19_RS18720	COG1607	acyl-coa hydrolase
BWR19_RS18725	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BWR19_RS18730	COG0210	DNA helicase
BWR19_RS18735	COG1737	Transcriptional regulator
BWR19_RS18745	COG1801	Protein of unknown function DUF72
BWR19_RS18750	COG0671	phosphoesterase, PA-phosphatase related
BWR19_RS18760	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BWR19_RS18765	COG1477	protein flavinylation
BWR19_RS18770	COG1968	undecaprenyl-diphosphatase activity
BWR19_RS18775	COG2239	Acts as a magnesium transporter
BWR19_RS18780	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BWR19_RS18785	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BWR19_RS18790	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BWR19_RS18795	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BWR19_RS18800	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BWR19_RS18805	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BWR19_RS18815	COG0356	it plays a direct role in the translocation of protons across the membrane
BWR19_RS18825	COG1475	DNA binding
BWR19_RS18830	COG1192	Involved in chromosome partitioning
BWR19_RS18835	COG0357	Ribosomal RNA small subunit methyltransferase G
BWR19_RS18840	COG0445	tRNA wobble uridine modification
BWR19_RS18850	COG0765	amino acid transport
BWR19_RS18855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BWR19_RS18860	COG0316	Belongs to the HesB IscA family
BWR19_RS18865	COG0038	chloride channel
BWR19_RS18870	COG1981	membrane
BWR19_RS18875	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BWR19_RS18875	COG0352	thiamine-phosphate diphosphorylase activity
BWR19_RS18875	COG0351	phosphomethylpyrimidine kinase
BWR19_RS18880	COG0352	thiamine-phosphate diphosphorylase activity
BWR19_RS18885	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BWR19_RS18905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BWR19_RS18910	COG2885	chlorophyll binding
BWR19_RS18915	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BWR19_RS18920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BWR19_RS18925	COG0706	membrane insertase activity
BWR19_RS18930	COG0594	ribonuclease P activity
BWR19_RS18935	COG0230	Belongs to the bacterial ribosomal protein bL34 family