locus-tag	class	description
IT895_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IT895_RS00010	COG0592	DNA-directed DNA polymerase activity
IT895_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IT895_RS00025	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IT895_RS00030	COG0751	glycine-tRNA ligase activity
IT895_RS00035	COG0752	glycyl-tRNA synthetase alpha subunit
IT895_RS00040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IT895_RS00045	COG0859	PFAM glycosyl transferase family 9
IT895_RS00060	COG0297	glycogen (starch) synthase activity
IT895_RS00065	COG0463	Glycosyl transferase, family 2
IT895_RS00070	COG0438	transferase activity, transferring glycosyl groups
IT895_RS00080	COG3642	lipopolysaccharide core region biosynthetic process
IT895_RS00090	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IT895_RS00090	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IT895_RS00095	COG1519	Transferase
IT895_RS00105	COG0438	transferase activity, transferring glycosyl groups
IT895_RS00140	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IT895_RS00145	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IT895_RS00150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IT895_RS00170	COG0006	proline dipeptidase activity
IT895_RS00175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT895_RS00180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT895_RS00185	COG0793	Belongs to the peptidase S41A family
IT895_RS00190	COG4942	peptidase
IT895_RS00195	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IT895_RS00200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IT895_RS00205	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IT895_RS00210	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IT895_RS00215	COG2996	Protein conserved in bacteria
IT895_RS00220	COG0189	ligase activity
IT895_RS00225	COG1678	Uncharacterized ACR, COG1678
IT895_RS00230	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IT895_RS00235	COG0540	Belongs to the ATCase OTCase family
IT895_RS00280	COG1558	bacterial-type flagellum-dependent cell motility
IT895_RS00285	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IT895_RS00290	COG1749	Flagellar hook protein flgE
IT895_RS00300	COG4786	Flagellar basal body rod
IT895_RS00310	COG1706	bacterial-type flagellum-dependent cell motility
IT895_RS00315	COG1705	Flagellar rod assembly protein muramidase FlgJ
IT895_RS00315	COG3951	Flagellar rod assembly protein muramidase FlgJ
IT895_RS00325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IT895_RS00335	COG1987	bacterial-type flagellum assembly
IT895_RS00340	COG1338	Plays a role in the flagellum-specific transport system
IT895_RS00345	COG3190	flagellar
IT895_RS00390	COG1766	The M ring may be actively involved in energy transduction
IT895_RS00400	COG1334	flagellar protein FlaG
IT895_RS00425	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IT895_RS00445	COG1360	Flagellar Motor Protein
IT895_RS00455	COG0835	chemotaxis
IT895_RS00460	COG0840	transmembrane signaling receptor activity
IT895_RS00465	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IT895_RS00470	COG2201	protein-glutamate methylesterase activity
IT895_RS00480	COG0745	RESPONSE REGULATOR receiver
IT895_RS00495	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IT895_RS00515	COG1191	sigma factor activity
IT895_RS00520	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IT895_RS00555	COG2814	Major facilitator Superfamily
IT895_RS00560	COG0629	single-stranded DNA binding
IT895_RS00580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IT895_RS00595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IT895_RS00610	COG0300	oxidoreductase activity
IT895_RS00630	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
IT895_RS00635	COG1090	epimerase
IT895_RS00640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IT895_RS00645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IT895_RS00680	COG1217	gtp-binding protein TYPA
IT895_RS00690	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IT895_RS00725	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IT895_RS00730	COG0081	regulation of translation
IT895_RS00735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IT895_RS00745	COG0085	RNA polymerase activity
IT895_RS00750	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IT895_RS00755	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IT895_RS00760	COG0049	tRNA binding
IT895_RS00765	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IT895_RS00770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IT895_RS00775	COG0051	transcription antitermination factor activity, RNA binding
IT895_RS00780	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IT895_RS00785	COG0088	Forms part of the polypeptide exit tunnel
IT895_RS00790	COG0089	rRNA binding
IT895_RS00795	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IT895_RS00800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IT895_RS00805	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IT895_RS00810	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IT895_RS00815	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IT895_RS00820	COG0255	Belongs to the universal ribosomal protein uL29 family
IT895_RS00825	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IT895_RS00830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IT895_RS00835	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IT895_RS00840	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IT895_RS00845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IT895_RS00850	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IT895_RS00855	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IT895_RS00860	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IT895_RS00865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IT895_RS00870	COG1841	ribosomal large subunit assembly
IT895_RS00875	COG0200	Binds to the 23S rRNA
IT895_RS00885	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IT895_RS00890	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IT895_RS00895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IT895_RS00900	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IT895_RS00905	COG0202	RNA polymerase activity
IT895_RS00910	COG0203	ribosomal protein L17
IT895_RS00915	COG1686	Belongs to the peptidase S11 family
IT895_RS00920	COG0697	spore germination
IT895_RS00925	COG0352	thiamine-phosphate diphosphorylase activity
IT895_RS00930	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IT895_RS00970	COG0803	Belongs to the bacterial solute-binding protein 9 family
IT895_RS00980	COG1121	(ABC) transporter
IT895_RS01020	COG3344	reverse transcriptase
IT895_RS01035	COG2204	response regulator
IT895_RS01050	COG5510	response to toxic substance
IT895_RS01055	COG0671	phosphoesterase, PA-phosphatase related
IT895_RS01070	COG3842	ATPase activity
IT895_RS01080	COG1175	transmembrane transport
IT895_RS01135	COG4974	Belongs to the 'phage' integrase family
IT895_RS01255	COG0142	geranyltranstransferase activity
IT895_RS01260	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IT895_RS01265	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IT895_RS01270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IT895_RS01275	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IT895_RS01295	COG0745	RESPONSE REGULATOR receiver
IT895_RS01310	COG3300	MHYT domain
IT895_RS01310	COG5001	Diguanylate cyclase
IT895_RS01320	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IT895_RS01325	COG3639	organic phosphonate transmembrane transporter activity
IT895_RS01335	COG0791	NLP P60 protein
IT895_RS01335	COG1388	LysM domain
IT895_RS01375	COG5001	Diguanylate cyclase
IT895_RS01380	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IT895_RS01390	COG3443	Belongs to the bacterial solute-binding protein 9 family
IT895_RS01395	COG3755	Protein conserved in bacteria
IT895_RS01405	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IT895_RS01410	COG2867	negative regulation of translational initiation
IT895_RS01420	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IT895_RS01430	COG0497	DNA recombination
IT895_RS01435	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IT895_RS01440	COG0443	Heat shock 70 kDa protein
IT895_RS01445	COG0484	heat shock protein binding
IT895_RS01455	COG1120	ATPase activity
IT895_RS01460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT895_RS01475	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IT895_RS01500	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IT895_RS01505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IT895_RS01510	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IT895_RS01515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IT895_RS01520	COG0149	triose-phosphate isomerase activity
IT895_RS01525	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IT895_RS01540	COG0779	Required for maturation of 30S ribosomal subunits
IT895_RS01545	COG0195	Participates in both transcription termination and antitermination
IT895_RS01550	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IT895_RS01555	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IT895_RS01560	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IT895_RS01565	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IT895_RS01570	COG1185	polyribonucleotide nucleotidyltransferase activity
IT895_RS01575	COG2814	Major facilitator Superfamily
IT895_RS01585	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IT895_RS01590	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IT895_RS01595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IT895_RS01605	COG0617	tRNA 3'-terminal CCA addition
IT895_RS01615	COG3852	Histidine kinase
IT895_RS01625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IT895_RS01630	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IT895_RS01635	COG0436	Aminotransferase
IT895_RS01640	COG1489	DNA binding
IT895_RS01650	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IT895_RS01680	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IT895_RS01685	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IT895_RS01725	COG0023	Translation Initiation Factor
IT895_RS01730	COG0546	phosphoglycolate phosphatase activity
IT895_RS01745	COG0126	phosphoglycerate kinase activity
IT895_RS01750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IT895_RS01755	COG1346	cytolysis
IT895_RS01765	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IT895_RS01770	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IT895_RS01775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IT895_RS01785	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IT895_RS01805	COG0339	signal peptide processing
IT895_RS01810	COG0733	neurotransmitter:sodium symporter activity
IT895_RS01815	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IT895_RS01855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IT895_RS01865	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IT895_RS01870	COG0709	Synthesizes selenophosphate from selenide and ATP
IT895_RS01875	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
IT895_RS01885	COG3068	Protein conserved in bacteria
IT895_RS01890	COG0107	imidazoleglycerol-phosphate synthase activity
IT895_RS01895	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IT895_RS01900	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IT895_RS01905	COG0131	Imidazoleglycerol-phosphate dehydratase
IT895_RS01920	COG1194	a g-specific adenine glycosylase
IT895_RS01925	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IT895_RS01945	COG4974	Belongs to the 'phage' integrase family
IT895_RS01955	COG1450	Type ii and iii secretion system protein
IT895_RS02015	COG0577	efflux transmembrane transporter activity
IT895_RS02020	COG4181	ATPase activity
IT895_RS02025	COG5285	phytanoyl-CoA dioxygenase
IT895_RS02030	COG0179	Fumarylacetoacetate (FAA) hydrolase
IT895_RS02035	COG1166	arginine decarboxylase activity
IT895_RS02105	COG3829	transcription factor binding
IT895_RS02135	COG3501	Rhs element vgr protein
IT895_RS02165	COG0583	DNA-binding transcription factor activity
IT895_RS02175	COG0006	proline dipeptidase activity
IT895_RS02210	COG1028	Short-chain dehydrogenase reductase Sdr
IT895_RS02220	COG0850	regulation of cytokinetic process
IT895_RS02225	COG2894	cell division
IT895_RS02230	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IT895_RS02235	COG2925	Exonuclease
IT895_RS02240	COG1025	Belongs to the peptidase M16 family
IT895_RS02260	COG4536	flavin adenine dinucleotide binding
IT895_RS02265	COG4137	Cytochrome C assembly protein
IT895_RS02270	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IT895_RS02275	COG0228	four-way junction DNA binding
IT895_RS02280	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IT895_RS02285	COG0336	Belongs to the RNA methyltransferase TrmD family
IT895_RS02290	COG0335	large ribosomal subunit rRNA binding
IT895_RS02300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IT895_RS02315	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IT895_RS02325	COG2217	Heavy metal translocating P-type atpase
IT895_RS02335	COG2067	long-chain fatty acid transport protein
IT895_RS02345	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IT895_RS02355	COG2814	Major facilitator Superfamily
IT895_RS02360	COG0271	Belongs to the BolA IbaG family
IT895_RS02380	COG0742	ribosomal rna small subunit methyltransferase
IT895_RS02385	COG0552	protein localization to endoplasmic reticulum
IT895_RS02390	COG2884	Cell division ATP-binding protein ftsE
IT895_RS02395	COG2177	Part of the ABC transporter FtsEX involved in
IT895_RS02405	COG1309	transcriptional regulator
IT895_RS02410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IT895_RS02425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IT895_RS02430	COG2003	Belongs to the UPF0758 family
IT895_RS02435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IT895_RS02440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IT895_RS02445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IT895_RS02450	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IT895_RS02460	COG0686	Belongs to the AlaDH PNT family
IT895_RS02480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IT895_RS02495	COG0436	Aminotransferase
IT895_RS02500	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IT895_RS02505	COG0024	Methionine aminopeptidase
IT895_RS02510	COG0052	Belongs to the universal ribosomal protein uS2 family
IT895_RS02515	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IT895_RS02520	COG0528	UMP kinase activity
IT895_RS02525	COG0233	cytoplasmic translational termination
IT895_RS02530	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IT895_RS02535	COG0575	Belongs to the CDS family
IT895_RS02540	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IT895_RS02560	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IT895_RS02565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IT895_RS02570	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IT895_RS02575	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IT895_RS02580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IT895_RS02590	COG0825	malonyl-CoA metabolic process
IT895_RS02595	COG0037	tRNA processing
IT895_RS02600	COG0248	Ppx GppA phosphatase
IT895_RS02610	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IT895_RS02645	COG0346	lactoylglutathione lyase activity
IT895_RS02660	COG3706	GGDEF domain
IT895_RS02670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IT895_RS02685	COG4136	ATPase activity
IT895_RS02690	COG4135	transport system, permease component
IT895_RS02695	COG4134	Bacterial extracellular solute-binding protein
IT895_RS02715	COG0038	chloride channel
IT895_RS02720	COG0525	valine-tRNA ligase activity
IT895_RS02745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IT895_RS02750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IT895_RS02755	COG0795	lipopolysaccharide-transporting ATPase activity
IT895_RS02760	COG0795	lipopolysaccharide-transporting ATPase activity
IT895_RS02790	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IT895_RS02800	COG3453	Protein conserved in bacteria
IT895_RS02800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IT895_RS02820	COG2226	methyltransferase
IT895_RS02845	COG4302	ethanolamine ammonia-lyase activity
IT895_RS02850	COG0531	amino acid
IT895_RS02875	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
IT895_RS02880	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IT895_RS02890	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IT895_RS02895	COG1073	alpha beta
IT895_RS02895	COG2226	methyltransferase
IT895_RS02905	COG0156	8-amino-7-oxononanoate synthase activity
IT895_RS02910	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IT895_RS02915	COG3148	PFAM DTW domain containing protein
IT895_RS02925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IT895_RS02930	COG0569	domain protein
IT895_RS02935	COG3360	Dodecin
IT895_RS02945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IT895_RS02950	COG0242	peptide deformylase activity
IT895_RS02960	COG0758	DNA mediated transformation
IT895_RS02965	COG0009	L-threonylcarbamoyladenylate synthase
IT895_RS02970	COG0408	coproporphyrinogen oxidase activity
IT895_RS02975	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IT895_RS02990	COG1160	GTP binding
IT895_RS03000	COG2976	Protein conserved in bacteria
IT895_RS03005	COG0124	histidyl-tRNA synthetase
IT895_RS03010	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IT895_RS03025	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IT895_RS03030	COG0105	UTP biosynthetic process
IT895_RS03040	COG1104	cysteine desulfurase activity
IT895_RS03075	COG1862	Preprotein translocase
IT895_RS03080	COG0343	queuine tRNA-ribosyltransferase activity
IT895_RS03085	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IT895_RS03095	COG0438	transferase activity, transferring glycosyl groups
IT895_RS03105	COG0251	oxidation-reduction process
IT895_RS03110	COG2423	ornithine cyclodeaminase activity
IT895_RS03115	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT895_RS03145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IT895_RS03175	COG0406	alpha-ribazole phosphatase activity
IT895_RS03185	COG0662	Cupin 2, conserved barrel domain protein
IT895_RS03205	COG1234	tRNA 3'-trailer cleavage
IT895_RS03225	COG0583	DNA-binding transcription factor activity
IT895_RS03240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IT895_RS03260	COG0596	Alpha beta hydrolase
IT895_RS03265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT895_RS03270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IT895_RS03275	COG2094	Belongs to the DNA glycosylase MPG family
IT895_RS03280	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IT895_RS03285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IT895_RS03300	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IT895_RS03310	COG5001	Diguanylate cyclase
IT895_RS03310	COG3300	MHYT domain
IT895_RS03315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IT895_RS03320	COG1960	acyl-CoA dehydrogenase activity
IT895_RS03325	COG1802	Transcriptional regulator
IT895_RS03330	COG0579	oxidoreductase
IT895_RS03385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IT895_RS03390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IT895_RS03395	COG0067	glutamate synthase
IT895_RS03395	COG0069	glutamate synthase activity
IT895_RS03395	COG0070	glutamate synthase
IT895_RS03400	COG0493	'glutamate synthase
IT895_RS03410	COG0504	CTP synthase activity
IT895_RS03415	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IT895_RS03420	COG0148	phosphopyruvate hydratase activity
IT895_RS03425	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IT895_RS03430	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IT895_RS03435	COG1546	Belongs to the CinA family
IT895_RS03440	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IT895_RS03445	COG2137	regulation of response to DNA damage stimulus
IT895_RS03450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IT895_RS03455	COG0527	aspartate kinase activity
IT895_RS03460	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IT895_RS03495	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IT895_RS03500	COG1739	Uncharacterized protein family UPF0029
IT895_RS03505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IT895_RS03510	COG4133	protoheme IX ABC transporter activity
IT895_RS03530	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IT895_RS03535	COG1138	Cytochrome C-type biogenesis protein
IT895_RS03560	COG3115	cell septum assembly
IT895_RS03565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IT895_RS03575	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IT895_RS03575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT895_RS03580	COG2350	Protein conserved in bacteria
IT895_RS03585	COG0613	PHP domain protein
IT895_RS03590	COG0009	L-threonylcarbamoyladenylate synthase
IT895_RS03595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IT895_RS03605	COG1392	Phosphate transport regulator
IT895_RS03610	COG0306	phosphate transporter
IT895_RS03615	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IT895_RS03615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IT895_RS03620	COG1028	Short-chain dehydrogenase reductase Sdr
IT895_RS03630	COG1570	exodeoxyribonuclease VII activity
IT895_RS03635	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IT895_RS03645	COG0519	Catalyzes the synthesis of GMP from XMP
IT895_RS03645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IT895_RS03720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IT895_RS03725	COG0473	3-isopropylmalate dehydrogenase activity
IT895_RS03725	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IT895_RS03735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IT895_RS03740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IT895_RS03765	COG0583	DNA-binding transcription factor activity
IT895_RS03770	COG2814	Major facilitator Superfamily
IT895_RS03820	COG2271	Major facilitator Superfamily
IT895_RS03825	COG4690	dipeptidase activity
IT895_RS03840	COG0583	DNA-binding transcription factor activity
IT895_RS03910	COG1131	(ABC) transporter
IT895_RS03930	COG3119	arylsulfatase activity
IT895_RS03950	COG0642	Histidine kinase
IT895_RS03985	COG0110	maltose O-acetyltransferase activity
IT895_RS03990	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
IT895_RS03995	COG2207	Transcriptional regulator
IT895_RS04010	COG0069	glutamate synthase activity
IT895_RS04015	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IT895_RS04020	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IT895_RS04040	COG0583	DNA-binding transcription factor activity
IT895_RS04045	COG1335	isochorismatase
IT895_RS04055	COG1741	Belongs to the pirin family
IT895_RS04105	COG1396	sequence-specific DNA binding
IT895_RS04115	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IT895_RS04120	COG0471	metal ion transport
IT895_RS04125	COG0420	3'-5' exonuclease activity
IT895_RS04130	COG0419	ATPase involved in DNA repair
IT895_RS04140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IT895_RS04145	COG1012	belongs to the aldehyde dehydrogenase family
IT895_RS04155	COG0583	DNA-binding transcription factor activity
IT895_RS04170	COG1278	Cold shock
IT895_RS04180	COG1295	ribonuclease BN
IT895_RS04185	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IT895_RS04195	COG0513	Belongs to the DEAD box helicase family
IT895_RS04205	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IT895_RS04210	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IT895_RS04215	COG0698	ribose 5-phosphate isomerase
IT895_RS04220	COG2376	Dihydroxyacetone kinase
IT895_RS04225	COG2390	Transcriptional regulator
IT895_RS04230	COG1063	alcohol dehydrogenase
IT895_RS04240	COG1129	ABC transporter
IT895_RS04245	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT895_RS04250	COG1879	ABC-type sugar transport system periplasmic component
IT895_RS04255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT895_RS04280	COG1609	Transcriptional regulator
IT895_RS04290	COG1132	(ABC) transporter
IT895_RS04295	COG0604	alcohol dehydrogenase
IT895_RS04300	COG0217	transcriptional regulatory protein
IT895_RS04310	COG0386	Belongs to the glutathione peroxidase family
IT895_RS04320	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IT895_RS04330	COG1028	Short-chain dehydrogenase reductase Sdr
IT895_RS04360	COG1012	belongs to the aldehyde dehydrogenase family
IT895_RS04365	COG3724	N-succinylarginine dihydrolase activity
IT895_RS04380	COG1846	Transcriptional regulator
IT895_RS04385	COG0778	Nitroreductase
IT895_RS04390	COG3706	GGDEF domain
IT895_RS04395	COG0456	acetyltransferase
IT895_RS04425	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT895_RS04435	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT895_RS04460	COG0598	Magnesium transport protein CorA
IT895_RS04465	COG0604	alcohol dehydrogenase
IT895_RS04470	COG3938	Belongs to the proline racemase family
IT895_RS04480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IT895_RS04490	COG0840	transmembrane signaling receptor activity
IT895_RS04495	COG0693	protein deglycase activity
IT895_RS04515	COG3530	Putative quorum-sensing-regulated virulence factor
IT895_RS04525	COG2207	Transcriptional regulator
IT895_RS04530	COG1064	alcohol dehydrogenase
IT895_RS04540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IT895_RS04545	COG2116	formate transmembrane transporter activity
IT895_RS04565	COG0584	glycerophosphoryl diester phosphodiesterase
IT895_RS04570	COG2133	pyrroloquinoline quinone binding
IT895_RS04590	COG0642	Histidine kinase
IT895_RS04605	COG0667	Aldo Keto reductase
IT895_RS04635	COG0159	tryptophan synthase activity
IT895_RS04685	COG1733	regulation of RNA biosynthetic process
IT895_RS04720	COG0840	transmembrane signaling receptor activity
IT895_RS04745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IT895_RS04760	COG4948	Mandelate Racemase Muconate Lactonizing
IT895_RS04775	COG3181	Tripartite tricarboxylate transporter family receptor
IT895_RS04790	COG2824	Alkylphosphonate utilization operon protein PhnA
IT895_RS04855	COG1522	sequence-specific DNA binding
IT895_RS04860	COG1113	amino acid transport
IT895_RS04870	COG3403	YqcI/YcgG family
IT895_RS04875	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IT895_RS04880	COG1074	ATP-dependent DNA helicase activity
IT895_RS04890	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IT895_RS04900	COG0129	dihydroxy-acid dehydratase activity
IT895_RS04915	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IT895_RS04925	COG3300	MHYT domain
IT895_RS04925	COG5001	Diguanylate cyclase
IT895_RS04930	COG5001	Diguanylate cyclase
IT895_RS04930	COG3300	MHYT domain
IT895_RS04940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT895_RS04945	COG4160	amino acid transport
IT895_RS04960	COG2988	succinylglutamate desuccinylase activity
IT895_RS04970	COG0655	NAD(P)H dehydrogenase (quinone) activity
IT895_RS04980	COG0473	3-isopropylmalate dehydrogenase activity
IT895_RS04985	COG0583	DNA-binding transcription factor activity
IT895_RS05005	COG2175	clavaminate synthase activity
IT895_RS05020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IT895_RS05020	COG3153	acetyltransferase
IT895_RS05030	COG0697	spore germination
IT895_RS05035	COG1902	pentaerythritol trinitrate reductase activity
IT895_RS05035	COG0446	pyridine nucleotide-disulphide oxidoreductase
IT895_RS05045	COG2766	serine protein kinase
IT895_RS05050	COG2718	Belongs to the UPF0229 family
IT895_RS05055	COG2719	SpoVR family
IT895_RS05090	COG0557	exoribonuclease II activity
IT895_RS05095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IT895_RS05100	COG0360	Binds together with S18 to 16S ribosomal RNA
IT895_RS05105	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IT895_RS05115	COG0359	binds to the 23S rRNA
IT895_RS05120	COG0305	Participates in initiation and elongation during chromosome replication
IT895_RS05120	COG1372	Participates in initiation and elongation during chromosome replication
IT895_RS05140	COG3046	protein related to deoxyribodipyrimidine photolyase
IT895_RS05150	COG1757	Na H antiporter
IT895_RS05155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT895_RS05170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IT895_RS05175	COG3938	Belongs to the proline racemase family
IT895_RS05190	COG0415	Belongs to the DNA photolyase family
IT895_RS05200	COG2951	lytic endotransglycosylase activity
IT895_RS05205	COG0189	ligase activity
IT895_RS05205	COG4067	protein conserved in archaea
IT895_RS05210	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IT895_RS05215	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
IT895_RS05220	COG0151	Belongs to the GarS family
IT895_RS05230	COG3954	Phosphoribulokinase
IT895_RS05235	COG0537	adenosine 5'-monophosphoramidase activity
IT895_RS05240	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IT895_RS05245	COG0488	(ABC) transporter
IT895_RS05255	COG1366	Belongs to the anti-sigma-factor antagonist family
IT895_RS05275	COG1538	Outer membrane efflux protein
IT895_RS05285	COG1132	(ABC) transporter
IT895_RS05290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT895_RS05310	COG5001	Diguanylate cyclase
IT895_RS05325	COG4181	ATPase activity
IT895_RS05330	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IT895_RS05335	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IT895_RS05345	COG3501	Rhs element vgr protein
IT895_RS05380	COG0471	metal ion transport
IT895_RS05380	COG3273	potassium ion transport
IT895_RS05385	COG1218	3'(2'),5'-bisphosphate nucleotidase
IT895_RS05430	COG0367	asparagine synthase
IT895_RS05435	COG0367	asparagine synthase
IT895_RS05455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IT895_RS05460	COG0110	maltose O-acetyltransferase activity
IT895_RS05465	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IT895_RS05480	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IT895_RS05490	COG1442	glycosyl transferase family 8
IT895_RS05500	COG1609	Transcriptional regulator
IT895_RS05505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IT895_RS05510	COG1028	Short-chain dehydrogenase reductase Sdr
IT895_RS05515	COG1070	Carbohydrate kinase
IT895_RS05520	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT895_RS05525	COG1129	ABC transporter
IT895_RS05530	COG1879	ABC-type sugar transport system periplasmic component
IT895_RS05570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IT895_RS05580	COG3181	Tripartite tricarboxylate transporter family receptor
IT895_RS05615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT895_RS05625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT895_RS05630	COG2721	sulfolactate sulfo-lyase activity
IT895_RS05645	COG2084	Dehydrogenase
IT895_RS05650	COG2084	Dehydrogenase
IT895_RS05675	COG1028	Short-chain dehydrogenase reductase Sdr
IT895_RS05680	COG1028	Short-chain dehydrogenase reductase Sdr
IT895_RS05685	COG0824	Thioesterase
IT895_RS05685	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT895_RS05705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IT895_RS05715	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT895_RS05720	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT895_RS05725	COG1129	ABC transporter
IT895_RS05730	COG4948	Mandelate Racemase Muconate Lactonizing
IT895_RS05735	COG1454	alcohol dehydrogenase
IT895_RS05740	COG1012	belongs to the aldehyde dehydrogenase family
IT895_RS05745	COG0583	DNA-binding transcription factor activity
IT895_RS05750	COG0583	DNA-binding transcription factor activity
IT895_RS05760	COG0006	proline dipeptidase activity
IT895_RS05775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IT895_RS05800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IT895_RS05840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IT895_RS05845	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT895_RS05855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT895_RS05860	COG1850	ribulose-bisphosphate carboxylase activity
IT895_RS05865	COG1609	Transcriptional regulator
IT895_RS05875	COG1802	Transcriptional regulator
IT895_RS05880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT895_RS05890	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IT895_RS05890	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT895_RS05895	COG0402	S-adenosylhomocysteine deaminase activity
IT895_RS05930	COG3181	Tripartite tricarboxylate transporter family receptor
IT895_RS05935	COG0402	S-adenosylhomocysteine deaminase activity
IT895_RS05945	COG3706	GGDEF domain
IT895_RS05950	COG1609	Transcriptional regulator
IT895_RS05955	COG2084	Dehydrogenase
IT895_RS05960	COG3395	kinase activity
IT895_RS05965	COG0235	Class ii aldolase
IT895_RS05970	COG3622	Belongs to the hyi family
IT895_RS05975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IT895_RS05980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT895_RS05990	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IT895_RS05990	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT895_RS05995	COG1012	belongs to the aldehyde dehydrogenase family
IT895_RS06000	COG2084	Dehydrogenase
IT895_RS06015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IT895_RS06030	COG2084	Dehydrogenase
IT895_RS06040	COG2009	succinate dehydrogenase
IT895_RS06045	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IT895_RS06050	COG1053	succinate dehydrogenase
IT895_RS06130	COG1175	transmembrane transport
IT895_RS06135	COG0395	ABC-type sugar transport system, permease component
IT895_RS06140	COG3842	ATPase activity
IT895_RS06145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IT895_RS06155	COG3106	COG3106 Predicted ATPase
IT895_RS06160	COG0676	glucose-6-phosphate 1-epimerase activity
IT895_RS06180	COG1360	Flagellar Motor Protein
IT895_RS06190	COG1215	transferase activity, transferring glycosyl groups
IT895_RS06195	COG0840	transmembrane signaling receptor activity
IT895_RS06205	COG0477	Major facilitator Superfamily
IT895_RS06210	COG0733	neurotransmitter:sodium symporter activity
IT895_RS06225	COG0596	Alpha beta hydrolase
IT895_RS06235	COG2840	Smr protein MutS2
IT895_RS06245	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IT895_RS06260	COG3243	poly(R)-hydroxyalkanoic acid synthase
IT895_RS06270	COG1999	signal sequence binding
IT895_RS06280	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IT895_RS06285	COG4535	Mg2 and Co2 transporter CorC
IT895_RS06290	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IT895_RS06295	COG1702	phosphate starvation-inducible protein PhoH
IT895_RS06300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IT895_RS06320	COG0640	Transcriptional regulator
IT895_RS06325	COG0793	Belongs to the peptidase S41A family
IT895_RS06330	COG1362	aminopeptidase activity
IT895_RS06340	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IT895_RS06345	COG0012	GTP binding
IT895_RS06350	COG0193	aminoacyl-tRNA hydrolase activity
IT895_RS06355	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IT895_RS06360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IT895_RS06370	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IT895_RS06375	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IT895_RS06385	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IT895_RS06390	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IT895_RS06395	COG2890	protein-(glutamine-N5) methyltransferase activity
IT895_RS06405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IT895_RS06435	COG3842	ATPase activity
IT895_RS06440	COG1176	ABC-type spermidine putrescine transport system, permease component I
IT895_RS06445	COG1177	transmembrane transport
IT895_RS06460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IT895_RS06465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT895_RS06470	COG2081	HI0933 family
IT895_RS06485	COG4575	ribosome binding
IT895_RS06495	COG1196	nuclear chromosome segregation
IT895_RS06495	COG3264	Mechanosensitive ion channel
IT895_RS06500	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IT895_RS06515	COG4991	sh3 domain protein
IT895_RS06520	COG0500	methyltransferase
IT895_RS06535	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IT895_RS06540	COG4208	sulfate ABC transporter
IT895_RS06545	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IT895_RS06550	COG4150	thiosulfate binding
IT895_RS06560	COG1252	NADH dehydrogenase
IT895_RS06565	COG0546	phosphoglycolate phosphatase activity
IT895_RS06575	COG0512	Glutamine amidotransferase of anthranilate synthase
IT895_RS06580	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IT895_RS06585	COG0134	indole-3-glycerol-phosphate synthase activity
IT895_RS06590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IT895_RS06595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT895_RS06600	COG0247	lactate metabolic process
IT895_RS06600	COG0277	FAD linked oxidase domain protein
IT895_RS06610	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IT895_RS06620	COG0628	permease
IT895_RS06625	COG3118	belongs to the thioredoxin family
IT895_RS06635	COG0175	sulfate reduction
IT895_RS06645	COG1802	Transcriptional regulator
IT895_RS06650	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IT895_RS06655	COG0372	Belongs to the citrate synthase family
IT895_RS06670	COG2079	MmgE PrpD family protein
IT895_RS06675	COG1555	photosystem II stabilization
IT895_RS06675	COG1596	polysaccharide export
IT895_RS06680	COG0284	orotidine-5'-phosphate decarboxylase activity
IT895_RS06685	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IT895_RS06695	COG0776	regulation of translation
IT895_RS06735	COG0322	excinuclease ABC activity
IT895_RS06750	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IT895_RS06755	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IT895_RS06760	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IT895_RS06765	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IT895_RS06770	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IT895_RS06780	COG3100	YcgL domain-containing protein
IT895_RS06785	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
IT895_RS06790	COG2983	Belongs to the UPF0260 family
IT895_RS06805	COG0121	glutamine amidotransferase
IT895_RS06810	COG0318	PFAM AMP-dependent synthetase and ligase
IT895_RS06815	COG1643	Atp-dependent helicase
IT895_RS06825	COG2853	Lipoprotein
IT895_RS06840	COG2814	Major facilitator Superfamily
IT895_RS06855	COG0573	inorganic phosphate transmembrane transporter activity
IT895_RS06865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IT895_RS06870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IT895_RS06880	COG0798	PFAM Bile acid sodium symporter
IT895_RS06885	COG0431	NADPH-dependent FMN reductase
IT895_RS06895	COG0840	transmembrane signaling receptor activity
IT895_RS06900	COG0183	Belongs to the thiolase family
IT895_RS06905	COG1309	transcriptional regulator
IT895_RS06910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IT895_RS06920	COG1960	acyl-CoA dehydrogenase activity
IT895_RS06940	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IT895_RS06970	COG3101	peptidyl-lysine hydroxylation
IT895_RS06980	COG0084	hydrolase, TatD family'
IT895_RS06985	COG0488	(ABC) transporter
IT895_RS06990	COG0589	response to stress
IT895_RS07015	COG0183	Belongs to the thiolase family
IT895_RS07035	COG1881	PFAM PEBP family protein
IT895_RS07045	COG0719	Fe-S assembly protein
IT895_RS07050	COG0396	ATPase activity
IT895_RS07055	COG0719	Fe-S assembly protein
IT895_RS07060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IT895_RS07070	COG2949	membrane
IT895_RS07080	COG0189	ligase activity
IT895_RS07100	COG3047	cAMP biosynthetic process
IT895_RS07115	COG0583	DNA-binding transcription factor activity
IT895_RS07125	COG3344	reverse transcriptase
IT895_RS07130	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IT895_RS07130	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IT895_RS07130	COG0506	proline dehydrogenase activity
IT895_RS07135	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IT895_RS07150	COG0517	IMP dehydrogenase activity
IT895_RS07150	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IT895_RS07150	COG0617	tRNA 3'-terminal CCA addition
IT895_RS07165	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IT895_RS07215	COG0166	Belongs to the GPI family
IT895_RS07220	COG3959	Transketolase, thiamine diphosphate binding domain
IT895_RS07225	COG3958	Transketolase
IT895_RS07230	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IT895_RS07245	COG1028	Short-chain dehydrogenase reductase Sdr
IT895_RS07250	COG1879	ABC-type sugar transport system periplasmic component
IT895_RS07260	COG1129	ABC transporter
IT895_RS07265	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT895_RS07270	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IT895_RS07280	COG0149	triose-phosphate isomerase activity
IT895_RS07285	COG0166	Belongs to the GPI family
IT895_RS07290	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IT895_RS07290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IT895_RS07290	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IT895_RS07295	COG1105	Belongs to the carbohydrate kinase PfkB family
IT895_RS07300	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT895_RS07300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IT895_RS07310	COG1803	Methylglyoxal synthase
IT895_RS07315	COG0469	pyruvate kinase activity
IT895_RS07325	COG1609	Transcriptional regulator
IT895_RS07330	COG3842	ATPase activity
IT895_RS07335	COG0366	Alpha amylase catalytic
IT895_RS07350	COG1653	transport
IT895_RS07365	COG1595	DNA-templated transcription, initiation
IT895_RS07390	COG3386	PFAM SMP-30 Gluconolaconase
IT895_RS07395	COG0800	Aldolase
IT895_RS07400	COG3734	2-keto-3-deoxy-galactonokinase
IT895_RS07405	COG4948	Mandelate Racemase Muconate Lactonizing
IT895_RS07410	COG2186	Transcriptional regulator
IT895_RS07415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT895_RS07420	COG4989	oxidoreductase activity
IT895_RS07425	COG0837	glucose binding
IT895_RS07435	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IT895_RS07440	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IT895_RS07450	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
IT895_RS07455	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IT895_RS07460	COG0406	alpha-ribazole phosphatase activity
IT895_RS07470	COG3501	Rhs element vgr protein
IT895_RS07515	COG1120	ATPase activity
IT895_RS07520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT895_RS07540	COG1797	cobyrinic acid a,c-diamide synthase activity
IT895_RS07575	COG2099	Precorrin-6x reductase
IT895_RS07590	COG2875	Belongs to the precorrin methyltransferase family
IT895_RS07620	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IT895_RS07625	COG0513	Belongs to the DEAD box helicase family
IT895_RS07670	COG1030	water channel activity
IT895_RS07695	COG1794	racemase activity, acting on amino acids and derivatives
IT895_RS07700	COG2066	Belongs to the glutaminase family
IT895_RS07705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IT895_RS07715	COG2197	response regulator
IT895_RS07725	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IT895_RS07755	COG3842	ATPase activity
IT895_RS07760	COG1177	transmembrane transport
IT895_RS07765	COG4149	molybdate abc transporter
IT895_RS07775	COG1609	Transcriptional regulator
IT895_RS07780	COG1492	cobalamin metabolic process
IT895_RS07800	COG0542	response to heat
IT895_RS07805	COG3284	Transcriptional regulator
IT895_RS07825	COG0006	proline dipeptidase activity
IT895_RS07830	COG0583	DNA-binding transcription factor activity
IT895_RS07835	COG4608	Belongs to the ABC transporter superfamily
IT895_RS07845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT895_RS07850	COG0601	transmembrane transport
IT895_RS07855	COG0747	negative chemotaxis
IT895_RS07865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IT895_RS07875	COG1280	lysine exporter protein (LysE YggA)
IT895_RS07890	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IT895_RS07895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IT895_RS07905	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IT895_RS07910	COG0768	penicillin binding
IT895_RS07915	COG0772	Belongs to the SEDS family
IT895_RS07920	COG2951	lytic endotransglycosylase activity
IT895_RS07930	COG1686	Belongs to the peptidase S11 family
IT895_RS07935	COG2921	Belongs to the UPF0250 family
IT895_RS07940	COG0321	lipoyl(octanoyl) transferase activity
IT895_RS07945	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IT895_RS07980	COG1376	ErfK ybiS ycfS ynhG family protein
IT895_RS07985	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IT895_RS07995	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IT895_RS08000	COG1805	sodium ion transport
IT895_RS08005	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IT895_RS08010	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IT895_RS08015	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IT895_RS08035	COG3344	reverse transcriptase
IT895_RS08060	COG0495	leucyl-tRNA aminoacylation
IT895_RS08085	COG2161	toxin-antitoxin pair type II binding
IT895_RS08095	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IT895_RS08110	COG1418	mRNA catabolic process
IT895_RS08130	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IT895_RS08135	COG0066	3-isopropylmalate dehydratase activity
IT895_RS08140	COG0473	3-isopropylmalate dehydrogenase activity
IT895_RS08160	COG0135	phosphoribosylanthranilate isomerase activity
IT895_RS08170	COG0159	tryptophan synthase activity
IT895_RS08175	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IT895_RS08180	COG0285	dihydrofolate synthase activity
IT895_RS08205	COG3038	cytochrome b561
IT895_RS08210	COG2353	YceI-like domain
IT895_RS08215	COG0534	Mate efflux family protein
IT895_RS08230	COG2154	pterin-4-alpha-carbinolamine dehydratase
IT895_RS08250	COG0489	protein tyrosine kinase activity
IT895_RS08255	COG0717	Belongs to the dCTP deaminase family
IT895_RS08260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IT895_RS08265	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IT895_RS08270	COG0628	permease
IT895_RS08310	COG1464	Belongs to the NlpA lipoprotein family
IT895_RS08315	COG2011	ABC-type metal ion transport system permease component
IT895_RS08320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IT895_RS08325	COG0307	riboflavin synthase, alpha
IT895_RS08330	COG2252	PERMEase
IT895_RS08335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IT895_RS08340	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IT895_RS08345	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IT895_RS08350	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IT895_RS08360	COG1763	Mo-molybdopterin cofactor biosynthetic process
IT895_RS08365	COG0315	cyclic pyranopterin monophosphate synthase activity
IT895_RS08385	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IT895_RS08395	COG1376	ErfK ybiS ycfS ynhG family protein
IT895_RS08405	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IT895_RS08410	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IT895_RS08420	COG0405	Gamma-glutamyltransferase
IT895_RS08425	COG0584	glycerophosphoryl diester phosphodiesterase
IT895_RS08430	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IT895_RS08460	COG0602	queuosine metabolic process
IT895_RS08465	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IT895_RS08480	COG0252	asparaginase activity
IT895_RS08485	COG2807	transmembrane transport
IT895_RS08495	COG0513	Belongs to the DEAD box helicase family
IT895_RS08510	COG3008	intermembrane lipid transfer
IT895_RS08510	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IT895_RS08515	COG2995	paraquat-inducible protein a
IT895_RS08525	COG1271	oxidase subunit
IT895_RS08530	COG1294	oxidase, subunit
IT895_RS08535	COG4988	ABC transporter
IT895_RS08540	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IT895_RS08545	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IT895_RS08575	COG0402	S-adenosylhomocysteine deaminase activity
IT895_RS08585	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IT895_RS08595	COG1309	transcriptional regulator
IT895_RS08600	COG1643	Atp-dependent helicase
IT895_RS08615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IT895_RS08615	COG1565	acr, cog1565
IT895_RS08620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IT895_RS08625	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IT895_RS08630	COG1845	cytochrome c oxidase, subunit III
IT895_RS08650	COG1612	heme a metabolic process
IT895_RS08660	COG2885	chlorophyll binding
IT895_RS08665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IT895_RS08670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IT895_RS08675	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IT895_RS08680	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IT895_RS08685	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IT895_RS08690	COG0072	phenylalanine-tRNA ligase activity
IT895_RS08695	COG0776	regulation of translation
IT895_RS08710	COG0544	peptidyl-prolyl cis-trans isomerase activity
IT895_RS08715	COG0740	serine-type endopeptidase activity
IT895_RS08720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IT895_RS08725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IT895_RS08735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IT895_RS08740	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IT895_RS08745	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IT895_RS08750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IT895_RS08755	COG0215	cysteine-tRNA ligase activity
IT895_RS08760	COG1732	Glycine betaine
IT895_RS08765	COG1174	glycine betaine transport
IT895_RS08770	COG1125	glycine betaine transport
IT895_RS08775	COG1174	glycine betaine transport
IT895_RS08785	COG0022	dehydrogenase e1 component
IT895_RS08795	COG0515	serine threonine protein kinase
IT895_RS08800	COG0659	secondary active sulfate transmembrane transporter activity
IT895_RS08810	COG2962	Rard protein
IT895_RS08825	COG4172	Belongs to the ABC transporter superfamily
IT895_RS08830	COG4239	(ABC) transporter, permease
IT895_RS08835	COG4174	ABC transporter (Permease)
IT895_RS08840	COG4166	transmembrane transport
IT895_RS08845	COG0741	lytic transglycosylase activity
IT895_RS08845	COG1388	LysM domain
IT895_RS08850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IT895_RS08860	COG0328	RNA-DNA hybrid ribonuclease activity
IT895_RS08865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IT895_RS08870	COG2816	NAD+ diphosphatase activity
IT895_RS08880	COG0616	signal peptide processing
IT895_RS08885	COG0640	Transcriptional regulator
IT895_RS08895	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IT895_RS08905	COG0322	excinuclease ABC activity
IT895_RS08910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IT895_RS08930	COG0530	calcium, potassium:sodium antiporter activity
IT895_RS08935	COG3706	GGDEF domain
IT895_RS08940	COG0277	FAD linked oxidase domain protein
IT895_RS08950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IT895_RS08970	COG3706	GGDEF domain
IT895_RS08980	COG2201	protein-glutamate methylesterase activity
IT895_RS08985	COG2197	response regulator
IT895_RS08990	COG0429	hydrolase of the alpha beta-hydrolase fold
IT895_RS09025	COG2920	part of a sulfur-relay system
IT895_RS09040	COG0259	pyridoxamine-phosphate oxidase activity
IT895_RS09060	COG2840	Smr protein MutS2
IT895_RS09070	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IT895_RS09075	COG0534	Mate efflux family protein
IT895_RS09085	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IT895_RS09085	COG0316	Belongs to the HesB IscA family
IT895_RS09100	COG2166	iron-sulfur cluster assembly
IT895_RS09105	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IT895_RS09110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IT895_RS09115	COG0735	belongs to the Fur family
IT895_RS09140	COG1917	Cupin 2, conserved barrel domain protein
IT895_RS09145	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IT895_RS09150	COG0456	acetyltransferase
IT895_RS09160	COG0288	reversible hydration of carbon dioxide
IT895_RS09165	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IT895_RS09190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IT895_RS09205	COG1028	Short-chain dehydrogenase reductase Sdr
IT895_RS09215	COG2885	chlorophyll binding
IT895_RS09220	COG0823	Involved in the tonB-independent uptake of proteins
IT895_RS09240	COG0824	Thioesterase
IT895_RS09245	COG2255	four-way junction helicase activity
IT895_RS09255	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IT895_RS09260	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IT895_RS09270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IT895_RS09275	COG1254	Belongs to the acylphosphatase family
IT895_RS09280	COG1295	ribonuclease BN
IT895_RS09285	COG1051	belongs to the nudix hydrolase family
IT895_RS09285	COG1056	cytidyltransferase-related domain
IT895_RS09290	COG0583	DNA-binding transcription factor activity
IT895_RS09295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IT895_RS09305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IT895_RS09310	COG0556	nucleotide-excision repair
IT895_RS09330	COG0084	hydrolase, TatD family'
IT895_RS09335	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IT895_RS09350	COG0004	ammonium transporteR
IT895_RS09375	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IT895_RS09380	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IT895_RS09385	COG0418	dihydroorotase activity
IT895_RS09395	COG2205	protein histidine kinase activity
IT895_RS09400	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IT895_RS09405	COG1028	Short-chain dehydrogenase reductase Sdr
IT895_RS09425	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IT895_RS09430	COG0583	DNA-binding transcription factor activity
IT895_RS09445	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IT895_RS09450	COG1115	amino acid carrier protein
IT895_RS09455	COG0509	glycine decarboxylation via glycine cleavage system
IT895_RS09465	COG0583	DNA-binding transcription factor activity
IT895_RS09470	COG1611	Belongs to the LOG family
IT895_RS09510	COG0583	DNA-binding transcription factor activity
IT895_RS09520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT895_RS09530	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
IT895_RS09545	COG0483	inositol monophosphate 1-phosphatase activity
IT895_RS09575	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IT895_RS09580	COG0237	dephospho-CoA kinase activity
IT895_RS09615	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IT895_RS09620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IT895_RS09630	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IT895_RS09640	COG0824	Thioesterase
IT895_RS09645	COG2974	May be involved in recombination
IT895_RS09660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IT895_RS09660	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IT895_RS09670	COG4657	Part of a membrane complex involved in electron transport
IT895_RS09675	COG2878	Part of a membrane complex involved in electron transport
IT895_RS09685	COG4658	electron transport chain
IT895_RS09690	COG4659	FMN binding
IT895_RS09695	COG4660	Part of a membrane complex involved in electron transport
IT895_RS09700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IT895_RS09710	COG0745	RESPONSE REGULATOR receiver
IT895_RS09715	COG5002	protein histidine kinase activity
IT895_RS09715	COG2176	DNA-directed DNA polymerase activity
IT895_RS09725	COG5002	protein histidine kinase activity
IT895_RS09740	COG0137	argininosuccinate synthase activity
IT895_RS09745	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IT895_RS09750	COG0205	6-phosphofructokinase activity
IT895_RS09760	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IT895_RS09770	COG0511	ligase activity, forming carbon-carbon bonds
IT895_RS09780	COG2264	protein methyltransferase activity
IT895_RS09790	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IT895_RS09805	COG0302	gtp cyclohydrolase
IT895_RS09830	COG1028	Short-chain dehydrogenase reductase Sdr
IT895_RS09835	COG3030	protein affecting phage T7 exclusion by the F plasmid
IT895_RS09840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IT895_RS09845	COG0459	protein refolding
IT895_RS09860	COG2056	Na+-H+ antiporter family
IT895_RS09865	COG2610	gluconate transmembrane transporter activity
IT895_RS09875	COG4651	solute:proton antiporter activity
IT895_RS09875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IT895_RS09880	COG1321	iron dependent repressor
IT895_RS09890	COG5642	Protein of unknown function (DUF2384)
IT895_RS09930	COG1960	acyl-CoA dehydrogenase activity
IT895_RS09935	COG3842	ATPase activity
IT895_RS09940	COG3842	ATPase activity
IT895_RS09950	COG0395	ABC-type sugar transport system, permease component
IT895_RS09965	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IT895_RS09975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IT895_RS09980	COG1349	DNA-binding transcription factor activity
IT895_RS09985	COG0471	metal ion transport
IT895_RS09985	COG3273	potassium ion transport
IT895_RS09990	COG1024	Enoyl-CoA hydratase
IT895_RS10000	COG1024	Enoyl-CoA hydratase
IT895_RS10010	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT895_RS10015	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT895_RS10025	COG0584	glycerophosphoryl diester phosphodiesterase
IT895_RS10030	COG1396	sequence-specific DNA binding
IT895_RS10035	COG0154	amidase activity
IT895_RS10040	COG3135	benzoate transporter
IT895_RS10050	COG0442	prolyl-tRNA aminoacylation
IT895_RS10055	COG0741	lytic transglycosylase activity
IT895_RS10080	COG2199	diguanylate cyclase activity
IT895_RS10090	COG1320	monovalent cation:proton antiporter activity
IT895_RS10095	COG2212	antiporter activity
IT895_RS10100	COG1863	multisubunit Na H antiporter MnhE subunit
IT895_RS10105	COG0651	ATP synthesis coupled electron transport
IT895_RS10110	COG1006	Multisubunit Na H antiporter MnhC subunit
IT895_RS10115	COG2111	Na H antiporter
IT895_RS10120	COG2111	Na H antiporter
IT895_RS10120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IT895_RS10125	COG1047	Peptidyl-prolyl cis-trans
IT895_RS10130	COG2211	Major facilitator Superfamily
IT895_RS10145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IT895_RS10150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IT895_RS10155	COG1285	pathogenesis
IT895_RS10160	COG1285	pathogenesis
IT895_RS10165	COG3263	regulation of cellular component size
IT895_RS10245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IT895_RS10275	COG3932	Exopolysaccharide synthesis, ExoD
IT895_RS10280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IT895_RS10290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IT895_RS10335	COG1024	Enoyl-CoA hydratase
IT895_RS10335	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT895_RS10340	COG1960	acyl-CoA dehydrogenase activity
IT895_RS10350	COG0559	Belongs to the binding-protein-dependent transport system permease family
IT895_RS10375	COG1960	acyl-CoA dehydrogenase activity
IT895_RS10380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IT895_RS10385	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IT895_RS10400	COG0318	PFAM AMP-dependent synthetase and ligase
IT895_RS10415	COG3501	Rhs element vgr protein
IT895_RS10450	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
IT895_RS10465	COG1187	pseudouridine synthase activity
IT895_RS10475	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IT895_RS10480	COG3956	TIGRFAM MazG family protein
IT895_RS10485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IT895_RS10490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IT895_RS10505	COG0736	holo-[acyl-carrier-protein] synthase activity
IT895_RS10510	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IT895_RS10515	COG1381	Involved in DNA repair and RecF pathway recombination
IT895_RS10525	COG0571	ribonuclease III activity
IT895_RS10535	COG0481	GTPase activity
IT895_RS10540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IT895_RS10565	COG1199	ATP-dependent helicase activity
IT895_RS10570	COG0513	Belongs to the DEAD box helicase family
IT895_RS10580	COG0708	Exodeoxyribonuclease III
IT895_RS10595	COG0848	biopolymer transport protein
IT895_RS10600	COG0811	peptide transport
IT895_RS10605	COG0811	peptide transport
IT895_RS10620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IT895_RS10625	COG1780	Probably involved in ribonucleotide reductase function
IT895_RS10630	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IT895_RS10635	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IT895_RS10655	COG0210	DNA helicase
IT895_RS10665	COG0084	hydrolase, TatD family'
IT895_RS10680	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IT895_RS10685	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IT895_RS10690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IT895_RS10695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IT895_RS10700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IT895_RS10715	COG0416	fatty acid biosynthetic process
IT895_RS10720	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IT895_RS10725	COG1399	metal-binding, possibly nucleic acid-binding protein
IT895_RS10730	COG0424	maF-like protein
IT895_RS10745	COG0564	pseudouridine synthase activity
IT895_RS10750	COG1530	ribonuclease E activity
IT895_RS10760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IT895_RS10765	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IT895_RS10770	COG2835	tetraacyldisaccharide 4'-kinase activity
IT895_RS10775	COG1663	tetraacyldisaccharide 4'-kinase activity
IT895_RS10780	COG1132	(ABC) transporter
IT895_RS10785	COG0658	competence protein
IT895_RS10785	COG2333	competence protein COMEC
IT895_RS10795	COG1136	(ABC) transporter
IT895_RS10800	COG4591	ABC-type transport system involved in lipoprotein release permease component
IT895_RS10805	COG2957	Belongs to the agmatine deiminase family
IT895_RS10810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IT895_RS10815	COG0352	thiamine-phosphate diphosphorylase activity
IT895_RS10825	COG0653	protein targeting
IT895_RS10840	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IT895_RS10860	COG1181	Belongs to the D-alanine--D-alanine ligase family
IT895_RS10865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IT895_RS10870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IT895_RS10875	COG0772	Belongs to the SEDS family
IT895_RS10880	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IT895_RS10885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IT895_RS10890	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IT895_RS10895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IT895_RS10905	COG3116	cell division
IT895_RS10910	COG0275	rRNA processing
IT895_RS10925	COG3107	peptidoglycan biosynthetic process
IT895_RS10930	COG0792	nuclease activity
IT895_RS10935	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IT895_RS10940	COG2823	Periplasmic or secreted lipoprotein
IT895_RS10945	COG2969	positive regulation of protein catabolic process
IT895_RS10950	COG0625	glutathione transferase activity
IT895_RS10955	COG2857	Cytochrome c1
IT895_RS10960	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IT895_RS10965	COG0723	plastoquinol--plastocyanin reductase activity
IT895_RS10970	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IT895_RS10975	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IT895_RS10980	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IT895_RS10995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IT895_RS11005	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IT895_RS11010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IT895_RS11015	COG5007	Belongs to the BolA IbaG family
IT895_RS11030	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IT895_RS11035	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IT895_RS11040	COG1127	ABC transporter
IT895_RS11050	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IT895_RS11060	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IT895_RS11065	COG1137	ATPase activity
IT895_RS11085	COG1660	Displays ATPase and GTPase activities
IT895_RS11090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT895_RS11095	COG0312	modulator of DNA gyrase
IT895_RS11100	COG3028	Belongs to the UPF0307 family
IT895_RS11105	COG0312	modulator of DNA gyrase
IT895_RS11120	COG0424	maF-like protein
IT895_RS11125	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IT895_RS11130	COG1792	Involved in formation and maintenance of cell shape
IT895_RS11135	COG1077	Cell shape determining protein MreB Mrl
IT895_RS11140	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IT895_RS11145	COG0154	amidase activity
IT895_RS11150	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IT895_RS11155	COG2062	phosphohistidine phosphatase, SixA
IT895_RS11160	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IT895_RS11165	COG0326	Molecular chaperone. Has ATPase activity
IT895_RS11170	COG3339	Conserved Protein
IT895_RS11185	COG1278	Cold shock
IT895_RS11195	COG1597	lipid kinase activity
IT895_RS11200	COG0308	aminopeptidase N
IT895_RS11205	COG1666	GTP binding
IT895_RS11210	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IT895_RS11215	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IT895_RS11220	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IT895_RS11225	COG0330	HflC and HflK could
IT895_RS11230	COG0330	HflC and HflK could
IT895_RS11235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IT895_RS11240	COG1923	regulation of RNA biosynthetic process
IT895_RS11245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IT895_RS11250	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IT895_RS11255	COG0860	N-Acetylmuramoyl-L-alanine amidase
IT895_RS11260	COG0802	atpase or kinase
IT895_RS11265	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IT895_RS11265	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IT895_RS11275	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IT895_RS11280	COG1162	GTPase activity
IT895_RS11290	COG0688	phosphatidylethanolamine metabolic process
IT895_RS11295	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IT895_RS11300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IT895_RS11305	COG1509	lysine 2,3-aminomutase activity
IT895_RS11315	COG4993	Dehydrogenase
IT895_RS11335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IT895_RS11335	COG2111	Na H antiporter
IT895_RS11340	COG1006	Multisubunit Na H antiporter MnhC subunit
IT895_RS11345	COG0651	ATP synthesis coupled electron transport
IT895_RS11350	COG1863	multisubunit Na H antiporter MnhE subunit
IT895_RS11355	COG2212	antiporter activity
IT895_RS11360	COG1320	monovalent cation:proton antiporter activity
IT895_RS11370	COG0560	Phosphoserine phosphatase
IT895_RS11370	COG3830	Belongs to the UPF0237 family
IT895_RS11385	COG0187	DNA topoisomerase II activity
IT895_RS11390	COG0166	Belongs to the GPI family
IT895_RS11395	COG4106	trans-aconitate 2-methyltransferase activity
IT895_RS11405	COG0500	methyltransferase
IT895_RS11425	COG2738	Putative neutral zinc metallopeptidase
IT895_RS11435	COG0693	protein deglycase activity
IT895_RS11440	COG1910	domain protein
IT895_RS11460	COG2895	sulfate adenylyltransferase (ATP) activity
IT895_RS11465	COG0175	sulfate reduction
IT895_RS11470	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IT895_RS11475	COG3151	Protein conserved in bacteria
IT895_RS11480	COG0494	nUDIX hydrolase
IT895_RS11490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IT895_RS11495	COG2813	Specifically methylates the guanine in position
IT895_RS11500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IT895_RS11505	COG1609	Transcriptional regulator
IT895_RS11510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT895_RS11520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IT895_RS11525	COG1028	Short-chain dehydrogenase reductase Sdr
IT895_RS11530	COG1312	Catalyzes the dehydration of D-mannonate
IT895_RS11535	COG0246	Mannitol dehydrogenase
IT895_RS11540	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT895_RS11545	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IT895_RS11550	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT895_RS11555	COG1063	alcohol dehydrogenase
IT895_RS11560	COG4948	Mandelate Racemase Muconate Lactonizing
IT895_RS11565	COG1802	Transcriptional regulator
IT895_RS11570	COG2721	sulfolactate sulfo-lyase activity
IT895_RS11575	COG1028	Short-chain dehydrogenase reductase Sdr
IT895_RS11580	COG0179	Fumarylacetoacetate (FAA) hydrolase
IT895_RS11585	COG1063	alcohol dehydrogenase
IT895_RS11595	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IT895_RS11600	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT895_RS11605	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IT895_RS11610	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT895_RS11615	COG3395	kinase activity
IT895_RS11625	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IT895_RS11630	COG1028	Short-chain dehydrogenase reductase Sdr
IT895_RS11635	COG4948	Mandelate Racemase Muconate Lactonizing
IT895_RS11640	COG3246	L-lysine catabolic process to acetate
IT895_RS11680	COG2056	Na+-H+ antiporter family
IT895_RS11685	COG2986	histidine ammonia-lyase
IT895_RS11695	COG0010	Belongs to the arginase family
IT895_RS11700	COG1228	amidohydrolase
IT895_RS11705	COG3314	Sporulation integral membrane protein YlbJ
IT895_RS11725	COG3300	MHYT domain
IT895_RS11725	COG5001	Diguanylate cyclase
IT895_RS11740	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IT895_RS11750	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IT895_RS11755	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IT895_RS11760	COG0730	response to heat
IT895_RS11790	COG3344	reverse transcriptase
IT895_RS11800	COG0039	L-malate dehydrogenase activity
IT895_RS11820	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IT895_RS11825	COG2918	glutathione biosynthetic process
IT895_RS11830	COG2183	response to ionizing radiation
IT895_RS11840	COG0583	DNA-binding transcription factor activity
IT895_RS11845	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IT895_RS11850	COG3344	reverse transcriptase
IT895_RS11860	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IT895_RS11865	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IT895_RS11870	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IT895_RS11875	COG1011	Hydrolase
IT895_RS11880	COG0494	nUDIX hydrolase
IT895_RS11885	COG0673	inositol 2-dehydrogenase activity
IT895_RS11900	COG1959	2 iron, 2 sulfur cluster binding
IT895_RS11900	COG1295	ribonuclease BN
IT895_RS11905	COG0582	viral genome integration into host DNA
IT895_RS11915	COG0789	Transcriptional regulator
IT895_RS11955	COG4983	Phage plasmid primase, P4 family domain protein
IT895_RS11960	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IT895_RS11995	COG2003	Belongs to the UPF0758 family
IT895_RS12035	COG3667	copper resistance
IT895_RS12065	COG2826	transposase and inactivated derivatives, IS30 family
IT895_RS12075	COG1376	ErfK ybiS ycfS ynhG family protein
IT895_RS12075	COG1388	LysM domain
IT895_RS12080	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IT895_RS12090	COG2217	Heavy metal translocating P-type atpase
IT895_RS12095	COG0789	Transcriptional regulator
IT895_RS12105	COG0739	heme binding
IT895_RS12110	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IT895_RS12110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IT895_RS12115	COG1230	cation diffusion facilitator family transporter
IT895_RS12125	COG0785	Cytochrome C biogenesis protein
IT895_RS12130	COG0450	alkyl hydroperoxide reductase
IT895_RS12150	COG0398	Pfam SNARE associated Golgi protein
IT895_RS12160	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IT895_RS12185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IT895_RS12195	COG0785	Cytochrome C biogenesis protein
IT895_RS12240	COG1007	ATP synthesis coupled electron transport
IT895_RS12245	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT895_RS12255	COG0713	ATP synthesis coupled electron transport
IT895_RS12265	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IT895_RS12270	COG0649	NAD binding
IT895_RS12275	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT895_RS12300	COG2801	Transposase and inactivated derivatives
IT895_RS12305	COG2801	Transposase and inactivated derivatives
IT895_RS12330	COG0328	RNA-DNA hybrid ribonuclease activity
IT895_RS12380	COG4695	Portal protein
IT895_RS12420	COG3772	lysozyme
IT895_RS12545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IT895_RS12635	COG0778	Nitroreductase
IT895_RS12640	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IT895_RS12640	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IT895_RS12645	COG0842	Transport permease protein
IT895_RS12650	COG1131	(ABC) transporter
IT895_RS12685	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT895_RS12695	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT895_RS12705	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IT895_RS12710	COG0840	transmembrane signaling receptor activity
IT895_RS12710	COG0840	transmembrane signaling receptor activity
IT895_RS12715	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IT895_RS12725	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IT895_RS12735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IT895_RS12740	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IT895_RS12750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IT895_RS12750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IT895_RS12755	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IT895_RS12760	COG0366	Alpha amylase catalytic
IT895_RS12770	COG2391	methyltransferase activity
IT895_RS12785	COG0436	Aminotransferase
IT895_RS12790	COG0501	Belongs to the peptidase M48B family
IT895_RS12795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT895_RS12810	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IT895_RS12810	COG0116	Belongs to the methyltransferase superfamily
IT895_RS12815	COG3130	regulation of translation
IT895_RS12820	COG0167	dihydroorotate dehydrogenase activity
IT895_RS12825	COG2902	Dehydrogenase
IT895_RS12830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IT895_RS12835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IT895_RS12845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IT895_RS12850	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IT895_RS12855	COG1674	ftsk spoiiie
IT895_RS12860	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IT895_RS12865	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IT895_RS12870	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IT895_RS12875	COG0542	response to heat
IT895_RS12890	COG1187	pseudouridine synthase activity
IT895_RS12900	COG0482	sulfurtransferase activity
IT895_RS12905	COG2915	High frequency lysogenization protein hflD homolog
IT895_RS12915	COG2850	peptidyl-arginine hydroxylation
IT895_RS12930	COG3133	Outer membrane lipoprotein
IT895_RS12945	COG0864	Transcriptional regulator
IT895_RS12955	COG0601	transmembrane transport
IT895_RS12965	COG1131	(ABC) transporter
IT895_RS12970	COG1124	(ABC) transporter
IT895_RS12975	COG2814	Major facilitator Superfamily
IT895_RS12980	COG0791	NLP P60 protein
IT895_RS13080	COG1538	Outer membrane efflux protein
IT895_RS13095	COG2116	formate transmembrane transporter activity
IT895_RS13100	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
IT895_RS13110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IT895_RS13115	COG1070	Carbohydrate kinase
IT895_RS13125	COG1072	(Pantothenic acid kinase))
IT895_RS13135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IT895_RS13140	COG3842	ATPase activity
IT895_RS13155	COG1653	transport
IT895_RS13165	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IT895_RS13175	COG0494	nUDIX hydrolase
IT895_RS13185	COG1764	response to oxidative stress
IT895_RS13190	COG0697	spore germination
IT895_RS13200	COG1609	Transcriptional regulator
IT895_RS13205	COG3265	gluconokinase activity
IT895_RS13210	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT895_RS13220	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT895_RS13225	COG1846	Transcriptional regulator
IT895_RS13230	COG1764	response to oxidative stress
IT895_RS13235	COG0625	glutathione transferase activity
IT895_RS13245	COG4774	siderophore transport
IT895_RS13255	COG1028	Short-chain dehydrogenase reductase Sdr
IT895_RS13260	COG0667	Aldo Keto reductase
IT895_RS13265	COG1309	transcriptional regulator
IT895_RS13285	COG0625	glutathione transferase activity
IT895_RS13290	COG1024	Enoyl-CoA hydratase
IT895_RS13295	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT895_RS13300	COG0318	PFAM AMP-dependent synthetase and ligase
IT895_RS13305	COG1960	acyl-CoA dehydrogenase activity
IT895_RS13340	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IT895_RS13390	COG3791	Glutathione-dependent formaldehyde-activating
IT895_RS13400	COG0583	DNA-binding transcription factor activity
IT895_RS13420	COG2207	Transcriptional regulator
IT895_RS13435	COG0656	L-ascorbic acid biosynthetic process
IT895_RS13475	COG1733	regulation of RNA biosynthetic process
IT895_RS13480	COG1028	Short-chain dehydrogenase reductase Sdr
IT895_RS13485	COG1063	alcohol dehydrogenase
IT895_RS13490	COG3153	acetyltransferase
IT895_RS13525	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IT895_RS13540	COG1063	alcohol dehydrogenase
IT895_RS13555	COG1566	PFAM secretion protein HlyD family protein
IT895_RS13565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IT895_RS13570	COG0857	belongs to the CobB CobQ family
IT895_RS13570	COG0280	phosphate acetyltransferase
IT895_RS13580	COG0109	protoheme IX farnesyltransferase activity
IT895_RS13585	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IT895_RS13590	COG1845	cytochrome c oxidase, subunit III
IT895_RS13595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IT895_RS13600	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IT895_RS13605	COG1349	DNA-binding transcription factor activity
IT895_RS13615	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IT895_RS13620	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IT895_RS13625	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IT895_RS13630	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IT895_RS13635	COG0813	purine-nucleoside phosphorylase activity
IT895_RS13660	COG0484	heat shock protein binding
IT895_RS13670	COG0668	transmembrane transport
IT895_RS13680	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IT895_RS13690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IT895_RS13690	COG0519	Catalyzes the synthesis of GMP from XMP
IT895_RS13695	COG1515	deoxyribonuclease V activity
IT895_RS13705	COG3237	CsbD-like
IT895_RS13715	COG0435	Glutathione S-transferase
IT895_RS13720	COG0583	DNA-binding transcription factor activity
IT895_RS13725	COG0739	heme binding
IT895_RS13730	COG2989	Protein conserved in bacteria
IT895_RS13745	COG2223	nitrite transmembrane transporter activity
IT895_RS13750	COG3707	response regulator
IT895_RS13755	COG4221	oxidoreductase activity
IT895_RS13760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IT895_RS13785	COG2059	Chromate
IT895_RS13790	COG2059	Chromate
IT895_RS13800	COG0840	transmembrane signaling receptor activity
IT895_RS13840	COG0515	serine threonine protein kinase
IT895_RS13840	COG2815	serine threonine protein kinase
IT895_RS13845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IT895_RS13845	COG1648	precorrin-2 dehydrogenase activity
IT895_RS13850	COG0243	molybdopterin cofactor binding
IT895_RS13855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IT895_RS13860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IT895_RS13860	COG2146	nitrite reductase [NAD(P)H] activity
IT895_RS13875	COG1115	amino acid carrier protein
IT895_RS13890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IT895_RS13895	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IT895_RS13905	COG4615	Cyclic peptide transporter
IT895_RS13915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT895_RS13945	COG4774	siderophore transport
IT895_RS13960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IT895_RS13995	COG1595	DNA-templated transcription, initiation
IT895_RS14000	COG0483	inositol monophosphate 1-phosphatase activity
IT895_RS14005	COG1120	ATPase activity
IT895_RS14015	COG1121	(ABC) transporter
IT895_RS14020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IT895_RS14045	COG0583	DNA-binding transcription factor activity
IT895_RS14050	COG3706	GGDEF domain
IT895_RS14060	COG0583	DNA-binding transcription factor activity
IT895_RS14075	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IT895_RS14080	COG2130	NADP-dependent
IT895_RS14085	COG4993	Dehydrogenase
IT895_RS14090	COG4772	TonB-dependent receptor
IT895_RS14105	COG1301	dicarboxylic acid transport
IT895_RS14115	COG1278	Cold shock
IT895_RS14120	COG2226	methyltransferase
IT895_RS14125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IT895_RS14130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT895_RS14135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT895_RS14145	COG1120	ATPase activity
IT895_RS14195	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IT895_RS14235	COG0732	type I restriction modification DNA specificity domain
IT895_RS14260	COG1132	(ABC) transporter
IT895_RS14265	COG1120	ATPase activity
IT895_RS14270	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT895_RS14275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT895_RS14285	COG0583	DNA-binding transcription factor activity
IT895_RS14290	COG2828	Protein conserved in bacteria
IT895_RS14315	COG4771	TonB-dependent receptor
IT895_RS14320	COG0583	DNA-binding transcription factor activity
IT895_RS14330	COG2133	pyrroloquinoline quinone binding
IT895_RS14335	COG3852	Histidine kinase
IT895_RS14350	COG4175	Glycine betaine
IT895_RS14350	COG0517	IMP dehydrogenase activity
IT895_RS14370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IT895_RS14395	COG5001	Diguanylate cyclase
IT895_RS14400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IT895_RS14415	COG1234	tRNA 3'-trailer cleavage
IT895_RS14420	COG0583	DNA-binding transcription factor activity
IT895_RS14440	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IT895_RS14445	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IT895_RS14450	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IT895_RS14465	COG0617	tRNA 3'-terminal CCA addition
IT895_RS14470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IT895_RS14475	COG2967	ApaG domain
IT895_RS14480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IT895_RS14490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IT895_RS14495	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IT895_RS14505	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IT895_RS14515	COG1765	OsmC-like protein
IT895_RS14520	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IT895_RS14525	COG1560	Kdo2-lipid A biosynthetic process
IT895_RS14530	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IT895_RS14540	COG1388	LysM domain
IT895_RS14540	COG4942	peptidase
IT895_RS14550	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IT895_RS14555	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IT895_RS14560	COG0585	pseudouridine synthase activity
IT895_RS14565	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IT895_RS14570	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IT895_RS14575	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IT895_RS14590	COG2202	Pas domain
IT895_RS14590	COG2205	protein histidine kinase activity
IT895_RS14600	COG1737	Transcriptional regulator
IT895_RS14620	COG0589	response to stress
IT895_RS14625	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IT895_RS14630	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IT895_RS14640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IT895_RS14645	COG0589	response to stress
IT895_RS14650	COG0659	secondary active sulfate transmembrane transporter activity
IT895_RS14655	COG0473	3-isopropylmalate dehydrogenase activity
IT895_RS14660	COG2217	Heavy metal translocating P-type atpase
IT895_RS14665	COG0789	Transcriptional regulator
IT895_RS14705	COG1595	DNA-templated transcription, initiation
IT895_RS14735	COG0450	alkyl hydroperoxide reductase
IT895_RS14740	COG1253	flavin adenine dinucleotide binding
IT895_RS14745	COG1854	S-ribosylhomocysteine lyase activity
IT895_RS14765	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT895_RS14770	COG1012	belongs to the aldehyde dehydrogenase family
IT895_RS14775	COG5001	Diguanylate cyclase
IT895_RS14775	COG4251	negative regulation of phosphorylation
IT895_RS14775	COG3706	GGDEF domain
IT895_RS14775	COG2203	Gaf domain
IT895_RS14800	COG1522	sequence-specific DNA binding
IT895_RS14805	COG3608	succinylglutamate desuccinylase aspartoacylase
IT895_RS14810	COG0006	proline dipeptidase activity
IT895_RS14815	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IT895_RS14820	COG0189	ligase activity
IT895_RS14820	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IT895_RS14840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT895_RS14845	COG1335	isochorismatase
IT895_RS14860	COG2431	L-lysine efflux transmembrane transporter activity
IT895_RS14865	COG0252	asparaginase activity
IT895_RS14870	COG1115	amino acid carrier protein
IT895_RS14875	COG1944	ATP diphosphatase activity
IT895_RS14885	COG1309	transcriptional regulator
IT895_RS14895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IT895_RS14900	COG2205	protein histidine kinase activity
IT895_RS14905	COG0745	RESPONSE REGULATOR receiver
IT895_RS14920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IT895_RS14930	COG0659	secondary active sulfate transmembrane transporter activity
IT895_RS14950	COG2205	protein histidine kinase activity
IT895_RS14950	COG0784	Response regulator, receiver
IT895_RS14995	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT895_RS15000	COG0697	spore germination
IT895_RS15010	COG3842	ATPase activity
IT895_RS15025	COG0469	pyruvate kinase activity
IT895_RS15030	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IT895_RS15035	COG3257	ureidoglycine aminohydrolase activity
IT895_RS15040	COG1126	abc transporter atp-binding protein
IT895_RS15045	COG0765	amino acid transport
IT895_RS15080	COG1953	Uracil, thiamine, allantoin
IT895_RS15095	COG2351	hydroxyisourate hydrolase activity
IT895_RS15115	COG1620	l-lactate permease
IT895_RS15120	COG0277	FAD linked oxidase domain protein
IT895_RS15125	COG0277	FAD linked oxidase domain protein
IT895_RS15130	COG0247	lactate metabolic process
IT895_RS15135	COG3193	protein, possibly involved in utilization of glycolate and propanediol
IT895_RS15175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IT895_RS15180	COG0037	tRNA processing
IT895_RS15200	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IT895_RS15210	COG2205	protein histidine kinase activity
IT895_RS15210	COG0784	Response regulator, receiver
IT895_RS15210	COG2198	Histidine kinase
IT895_RS15220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IT895_RS15225	COG3091	SprT-like family
IT895_RS15240	COG0742	ribosomal rna small subunit methyltransferase
IT895_RS15250	COG0563	adenylate kinase activity
IT895_RS15280	COG1720	tRNA m6t6A37 methyltransferase activity
IT895_RS15285	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IT895_RS15295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IT895_RS15300	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IT895_RS15310	COG0425	Belongs to the sulfur carrier protein TusA family
IT895_RS15320	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IT895_RS15340	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IT895_RS15345	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IT895_RS15350	COG1061	Type III restriction enzyme res subunit
IT895_RS15360	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IT895_RS15370	COG0590	tRNA wobble adenosine to inosine editing
IT895_RS15375	COG1946	Acyl-CoA thioesterase
IT895_RS15380	COG0281	malic enzyme
IT895_RS15385	COG0254	rRNA binding
IT895_RS15390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IT895_RS15395	COG0018	arginyl-trna synthetase
IT895_RS15405	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IT895_RS15410	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IT895_RS15430	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IT895_RS15435	COG0140	phosphoribosyl-ATP diphosphatase activity
IT895_RS15440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IT895_RS15445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IT895_RS15455	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IT895_RS15470	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IT895_RS15475	COG0583	DNA-binding transcription factor activity
IT895_RS15480	COG2205	protein histidine kinase activity
IT895_RS15485	COG0745	RESPONSE REGULATOR receiver
IT895_RS15540	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IT895_RS15545	COG2027	D-alanyl-D-alanine carboxypeptidase
IT895_RS15565	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IT895_RS15570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IT895_RS15575	COG0534	Mate efflux family protein
IT895_RS15580	COG2031	fatty acid transporter
IT895_RS15585	COG1607	acyl-coa hydrolase
IT895_RS15630	COG1929	Belongs to the glycerate kinase type-1 family
IT895_RS15635	COG0783	Belongs to the Dps family
IT895_RS15640	COG2195	Cleaves the N-terminal amino acid of tripeptides
IT895_RS15645	COG1444	tRNA N-acetyltransferase activity
IT895_RS15650	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT895_RS15665	COG1178	ABC-type Fe3 transport system permease component
IT895_RS15670	COG3842	ATPase activity
IT895_RS15675	COG1840	ABC-type Fe3 transport system, periplasmic component
IT895_RS15700	COG1183	phosphatidylcholine synthase activity
IT895_RS15705	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IT895_RS15715	COG0440	acetolactate synthase activity
IT895_RS15720	COG0028	Belongs to the TPP enzyme family
IT895_RS15735	COG0564	pseudouridine synthase activity
IT895_RS15745	COG0840	transmembrane signaling receptor activity
IT895_RS15755	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IT895_RS15755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IT895_RS15770	COG2165	general secretion pathway protein
IT895_RS15775	COG0492	ferredoxin-NADP+ reductase activity
IT895_RS15790	COG2391	methyltransferase activity
IT895_RS15795	COG3118	belongs to the thioredoxin family
IT895_RS15800	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IT895_RS15840	COG0667	Aldo Keto reductase
IT895_RS15845	COG3022	response to hydroperoxide
IT895_RS15855	COG0180	Tryptophanyl-tRNA synthetase
IT895_RS15875	COG4969	Belongs to the N-Me-Phe pilin family
IT895_RS15885	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IT895_RS15890	COG1047	Peptidyl-prolyl cis-trans
IT895_RS15895	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IT895_RS15900	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IT895_RS15905	COG0196	riboflavin kinase activity
IT895_RS15915	COG0268	Binds directly to 16S ribosomal RNA
IT895_RS15920	COG1126	abc transporter atp-binding protein
IT895_RS15935	COG0840	transmembrane signaling receptor activity
IT895_RS15955	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IT895_RS15960	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IT895_RS15985	COG3932	Exopolysaccharide synthesis, ExoD
IT895_RS15995	COG3081	Nucleoid-associated protein
IT895_RS16000	COG0842	Transport permease protein
IT895_RS16005	COG1131	(ABC) transporter
IT895_RS16025	COG1028	Short-chain dehydrogenase reductase Sdr
IT895_RS16030	COG0673	inositol 2-dehydrogenase activity
IT895_RS16045	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT895_RS16055	COG1940	carbohydrate kinase activity
IT895_RS16055	COG1846	Transcriptional regulator
IT895_RS16060	COG1028	Short-chain dehydrogenase reductase Sdr
IT895_RS16075	COG1129	ABC transporter
IT895_RS16100	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT895_RS16140	COG0129	dihydroxy-acid dehydratase activity
IT895_RS16145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT895_RS16155	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT895_RS16165	COG0277	FAD linked oxidase domain protein
IT895_RS16170	COG1012	belongs to the aldehyde dehydrogenase family
IT895_RS16175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IT895_RS16180	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IT895_RS16190	COG3314	Sporulation integral membrane protein YlbJ
IT895_RS16200	COG3290	protein histidine kinase activity
IT895_RS16200	COG3829	transcription factor binding
IT895_RS16210	COG1653	transport
IT895_RS16220	COG0395	ABC-type sugar transport system, permease component
IT895_RS16225	COG0514	ATP-dependent DNA helicase (RecQ)
IT895_RS16230	COG3706	GGDEF domain
IT895_RS16240	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IT895_RS16260	COG2814	Major facilitator Superfamily
IT895_RS16265	COG4977	sequence-specific DNA binding
IT895_RS16270	COG2188	Transcriptional regulator
IT895_RS16275	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT895_RS16295	COG0318	PFAM AMP-dependent synthetase and ligase
IT895_RS16300	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IT895_RS16325	COG0754	glutathionylspermidine amidase activity
IT895_RS16335	COG0521	Mo-molybdopterin cofactor biosynthetic process
IT895_RS16350	COG0437	4 iron, 4 sulfur cluster binding
IT895_RS16355	COG0243	molybdopterin cofactor binding
IT895_RS16355	COG3383	formate dehydrogenase (NAD+) activity
IT895_RS16370	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT895_RS16385	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IT895_RS16390	COG0746	molybdenum cofactor guanylyltransferase activity
IT895_RS16395	COG0303	'Molybdopterin
IT895_RS16400	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IT895_RS16405	COG0523	cobalamin synthesis protein
IT895_RS16410	COG5001	Diguanylate cyclase
IT895_RS16420	COG1953	Uracil, thiamine, allantoin
IT895_RS16445	COG3119	arylsulfatase activity
IT895_RS16450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IT895_RS16460	COG2175	clavaminate synthase activity
IT895_RS16475	COG0583	DNA-binding transcription factor activity
IT895_RS16490	COG0840	transmembrane signaling receptor activity
IT895_RS16510	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IT895_RS16515	COG0402	S-adenosylhomocysteine deaminase activity
IT895_RS16520	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IT895_RS16525	COG2161	toxin-antitoxin pair type II binding
IT895_RS16530	COG4115	mRNA cleavage
IT895_RS16555	COG2818	Glycosylase
IT895_RS16560	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IT895_RS16575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT895_RS16585	COG0384	phenazine biosynthesis protein PhzF
IT895_RS16590	COG1830	Aldolase
IT895_RS16595	COG0071	Belongs to the small heat shock protein (HSP20) family
IT895_RS16610	COG1309	transcriptional regulator
IT895_RS16625	COG1760	l-serine dehydratase
IT895_RS16655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IT895_RS16665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IT895_RS16675	COG3383	formate dehydrogenase (NAD+) activity
IT895_RS16685	COG1063	alcohol dehydrogenase
IT895_RS16690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IT895_RS16710	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IT895_RS16715	COG0247	lactate metabolic process
IT895_RS16715	COG2181	nitrate reductase activity
IT895_RS16720	COG1902	pentaerythritol trinitrate reductase activity
IT895_RS16720	COG0446	pyridine nucleotide-disulphide oxidoreductase
IT895_RS16740	COG2329	Antibiotic biosynthesis monooxygenase
IT895_RS16745	COG0415	Belongs to the DNA photolyase family
IT895_RS16750	COG1012	belongs to the aldehyde dehydrogenase family
IT895_RS16755	COG0531	amino acid
IT895_RS16760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT895_RS16770	COG0006	proline dipeptidase activity
IT895_RS16780	COG1288	antiporter activity
IT895_RS16800	COG1902	pentaerythritol trinitrate reductase activity
IT895_RS16815	COG0488	(ABC) transporter
IT895_RS16825	COG0123	including yeast histone deacetylase and acetoin utilization protein
IT895_RS16840	COG1960	acyl-CoA dehydrogenase activity
IT895_RS16850	COG0583	DNA-binding transcription factor activity
IT895_RS16855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT895_RS16865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT895_RS16870	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IT895_RS16875	COG4221	oxidoreductase activity
IT895_RS16880	COG3706	GGDEF domain
IT895_RS16895	COG2832	Protein of unknown function (DUF454)
IT895_RS16905	COG2239	Acts as a magnesium transporter
IT895_RS16910	COG0673	inositol 2-dehydrogenase activity
IT895_RS16925	COG3962	Belongs to the TPP enzyme family
IT895_RS16930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT895_RS16960	COG0673	inositol 2-dehydrogenase activity
IT895_RS16965	COG3718	enzyme involved in inositol metabolism
IT895_RS16985	COG3706	GGDEF domain
IT895_RS16990	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT895_RS17005	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IT895_RS17010	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IT895_RS17015	COG1984	allophanate hydrolase subunit 2
IT895_RS17025	COG1959	2 iron, 2 sulfur cluster binding
IT895_RS17030	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IT895_RS17035	COG0667	Aldo Keto reductase
IT895_RS17040	COG1132	(ABC) transporter
IT895_RS17045	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IT895_RS17055	COG2873	o-acetylhomoserine
IT895_RS17060	COG1469	GTP cyclohydrolase I activity
IT895_RS17070	COG1280	lysine exporter protein (LysE YggA)
IT895_RS17090	COG1278	Cold shock
IT895_RS17125	COG1380	Effector of murein hydrolase LrgA
IT895_RS17130	COG1346	cytolysis
IT895_RS17150	COG0745	RESPONSE REGULATOR receiver
IT895_RS17180	COG3344	reverse transcriptase
IT895_RS17205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IT895_RS17210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IT895_RS17235	COG0129	dihydroxy-acid dehydratase activity
IT895_RS17265	COG4974	Belongs to the 'phage' integrase family
IT895_RS17270	COG0517	IMP dehydrogenase activity
IT895_RS17315	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT895_RS17355	COG0235	Class ii aldolase
IT895_RS17395	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT895_RS17415	COG3039	Transposase
IT895_RS17490	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IT895_RS17505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT895_RS17510	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT895_RS17510	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IT895_RS17515	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IT895_RS17515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT895_RS17535	COG0583	DNA-binding transcription factor activity
IT895_RS17550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IT895_RS17555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IT895_RS17560	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IT895_RS17580	COG3383	formate dehydrogenase (NAD+) activity
IT895_RS17585	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IT895_RS17600	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IT895_RS17605	COG0830	nickel cation binding
IT895_RS17610	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IT895_RS17615	COG0804	urea catabolic process
IT895_RS17620	COG0832	Belongs to the urease beta subunit family
IT895_RS17625	COG0831	urea catabolic process
IT895_RS17630	COG0829	nickel cation binding
IT895_RS17640	COG0803	Belongs to the bacterial solute-binding protein 9 family
IT895_RS17645	COG1121	(ABC) transporter
IT895_RS17650	COG1321	iron dependent repressor
IT895_RS17650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IT895_RS17655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IT895_RS17675	COG0559	Belongs to the binding-protein-dependent transport system permease family
IT895_RS17700	COG4565	transcriptional regulatory protein
IT895_RS17705	COG3290	protein histidine kinase activity
IT895_RS17715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IT895_RS17725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IT895_RS17730	COG1028	Short-chain dehydrogenase reductase Sdr
IT895_RS17735	COG0668	transmembrane transport
IT895_RS17740	COG1238	metal cluster binding
IT895_RS17750	COG1054	Belongs to the UPF0176 family
IT895_RS17755	COG1741	Belongs to the pirin family
IT895_RS17760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT895_RS17765	COG1722	exodeoxyribonuclease VII activity
IT895_RS17770	COG0142	geranyltranstransferase activity
IT895_RS17775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IT895_RS17780	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IT895_RS17790	COG0625	glutathione transferase activity
IT895_RS17795	COG1272	protein, Hemolysin III
IT895_RS17800	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IT895_RS17805	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IT895_RS17810	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IT895_RS17815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT895_RS17820	COG4597	amino acid ABC transporter
IT895_RS17825	COG0765	amino acid transport
IT895_RS17830	COG1126	abc transporter atp-binding protein
IT895_RS17835	COG0251	oxidation-reduction process
IT895_RS17855	COG3639	organic phosphonate transmembrane transporter activity
IT895_RS17870	COG0840	transmembrane signaling receptor activity
IT895_RS17875	COG0840	transmembrane signaling receptor activity
IT895_RS17880	COG0583	DNA-binding transcription factor activity
IT895_RS17895	COG0004	ammonium transporteR
IT895_RS17920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IT895_RS17925	COG0606	chelatase, subunit chli
IT895_RS17945	COG2831	hemolysin activation secretion protein
IT895_RS17960	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IT895_RS17980	COG3300	MHYT domain
IT895_RS17980	COG5001	Diguanylate cyclase
IT895_RS17985	COG0840	transmembrane signaling receptor activity
IT895_RS17995	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IT895_RS17995	COG2199	diguanylate cyclase activity
IT895_RS18000	COG2363	Small membrane protein
IT895_RS18015	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IT895_RS18030	COG2186	Transcriptional regulator
IT895_RS18040	COG2721	sulfolactate sulfo-lyase activity
IT895_RS18065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IT895_RS18080	COG1999	signal sequence binding
IT895_RS18090	COG0545	Peptidyl-prolyl cis-trans isomerase
IT895_RS18095	COG0589	response to stress
IT895_RS18100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT895_RS18105	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IT895_RS18110	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT895_RS18120	COG0488	(ABC) transporter
IT895_RS18125	COG1490	D-aminoacyl-tRNA deacylase activity
IT895_RS18145	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT895_RS18150	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT895_RS18175	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IT895_RS18180	COG1011	Hydrolase
IT895_RS18185	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IT895_RS18195	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IT895_RS18200	COG0019	diaminopimelate decarboxylase activity
IT895_RS18210	COG0165	Argininosuccinate lyase
IT895_RS18220	COG0181	hydroxymethylbilane synthase activity
IT895_RS18240	COG0589	response to stress
IT895_RS18250	COG3135	benzoate transporter
IT895_RS18255	COG3135	benzoate transporter
IT895_RS18260	COG1028	Short-chain dehydrogenase reductase Sdr
IT895_RS18285	COG4829	muconolactone delta-isomerase
IT895_RS18290	COG4948	Mandelate Racemase Muconate Lactonizing
IT895_RS18315	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IT895_RS18345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT895_RS18350	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT895_RS18355	COG1012	belongs to the aldehyde dehydrogenase family
IT895_RS18360	COG1024	Enoyl-CoA hydratase
IT895_RS18380	COG3320	Male sterility
IT895_RS18380	COG1022	Amp-dependent synthetase and ligase
IT895_RS18385	COG0183	Belongs to the thiolase family
IT895_RS18395	COG1802	Transcriptional regulator
IT895_RS18410	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT895_RS18415	COG3485	protocatechuate 3,4-dioxygenase
IT895_RS18420	COG3485	protocatechuate 3,4-dioxygenase
IT895_RS18425	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IT895_RS18430	COG0183	Belongs to the thiolase family
IT895_RS18435	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IT895_RS18440	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IT895_RS18465	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT895_RS18470	COG1082	Xylose isomerase domain protein TIM barrel
IT895_RS18470	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IT895_RS18475	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IT895_RS18485	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IT895_RS18490	COG1414	Transcriptional regulator
IT895_RS18495	COG5383	Protein conserved in bacteria
IT895_RS18500	COG1801	Protein of unknown function DUF72
IT895_RS18505	COG0733	neurotransmitter:sodium symporter activity
IT895_RS18515	COG1737	Transcriptional regulator
IT895_RS18520	COG0210	DNA helicase
IT895_RS18530	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT895_RS18550	COG0581	inorganic phosphate transmembrane transporter activity
IT895_RS18555	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IT895_RS18560	COG0704	Plays a role in the regulation of phosphate uptake
IT895_RS18565	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
IT895_RS18580	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IT895_RS18585	COG3161	chorismate lyase activity
IT895_RS18605	COG1289	transmembrane transporter activity
IT895_RS18610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IT895_RS18615	COG0583	DNA-binding transcription factor activity
IT895_RS18630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IT895_RS18635	COG1758	RNA polymerase activity
IT895_RS18640	COG0194	GDP metabolic process
IT895_RS18650	COG2814	Major facilitator Superfamily
IT895_RS18660	COG1741	Belongs to the pirin family
IT895_RS18710	COG0785	Cytochrome C biogenesis protein
IT895_RS18720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IT895_RS18755	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IT895_RS18760	COG4235	cytochrome complex assembly
IT895_RS18790	COG0789	Transcriptional regulator
IT895_RS18795	COG0398	Pfam SNARE associated Golgi protein
IT895_RS18810	COG0789	Transcriptional regulator
IT895_RS18815	COG0450	alkyl hydroperoxide reductase
IT895_RS18820	COG0785	Cytochrome C biogenesis protein
IT895_RS18825	COG2226	methyltransferase
IT895_RS18845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IT895_RS18855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IT895_RS18860	COG4942	peptidase
IT895_RS18865	COG0789	Transcriptional regulator
IT895_RS18870	COG2217	Heavy metal translocating P-type atpase
IT895_RS18880	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IT895_RS18885	COG1388	LysM domain
IT895_RS18885	COG1376	ErfK ybiS ycfS ynhG family protein
IT895_RS18900	COG1999	signal sequence binding
IT895_RS18995	COG0582	viral genome integration into host DNA
IT895_RS19000	COG1561	YicC-like family, N-terminal region
IT895_RS19005	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IT895_RS19010	COG0708	Exodeoxyribonuclease III
IT895_RS19015	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IT895_RS19020	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IT895_RS19025	COG0210	DNA helicase
IT895_RS19045	COG0642	Histidine kinase
IT895_RS19055	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IT895_RS19095	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IT895_RS19100	COG1477	protein flavinylation
IT895_RS19105	COG1968	undecaprenyl-diphosphatase activity
IT895_RS19115	COG2239	Acts as a magnesium transporter
IT895_RS19120	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IT895_RS19125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IT895_RS19130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IT895_RS19135	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IT895_RS19140	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IT895_RS19145	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IT895_RS19155	COG0356	it plays a direct role in the translocation of protons across the membrane
IT895_RS19165	COG1475	DNA binding
IT895_RS19170	COG1192	Involved in chromosome partitioning
IT895_RS19175	COG0357	Ribosomal RNA small subunit methyltransferase G
IT895_RS19180	COG0445	tRNA wobble uridine modification
IT895_RS19190	COG0765	amino acid transport
IT895_RS19195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT895_RS19200	COG0316	Belongs to the HesB IscA family
IT895_RS19210	COG0038	chloride channel
IT895_RS19215	COG1981	membrane
IT895_RS19220	COG0352	thiamine-phosphate diphosphorylase activity
IT895_RS19220	COG0351	phosphomethylpyrimidine kinase
IT895_RS19220	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IT895_RS19225	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IT895_RS19245	COG1462	curli production assembly transport component CsgG
IT895_RS19265	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IT895_RS19270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IT895_RS19275	COG2885	chlorophyll binding
IT895_RS19280	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IT895_RS19285	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IT895_RS19290	COG0706	membrane insertase activity
IT895_RS19295	COG0594	ribonuclease P activity
IT895_RS19300	COG0230	Belongs to the bacterial ribosomal protein bL34 family