locus-tag	class	description
CLAM6_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLAM6_RS00010	COG0592	DNA-directed DNA polymerase activity
CLAM6_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLAM6_RS00035	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CLAM6_RS00040	COG0751	glycine-tRNA ligase activity
CLAM6_RS00045	COG0752	glycyl-tRNA synthetase alpha subunit
CLAM6_RS00050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLAM6_RS00065	COG0297	glycogen (starch) synthase activity
CLAM6_RS00075	COG3642	lipopolysaccharide core region biosynthetic process
CLAM6_RS00080	COG0859	PFAM glycosyl transferase family 9
CLAM6_RS00085	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CLAM6_RS00085	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CLAM6_RS00090	COG1519	Transferase
CLAM6_RS00095	COG1349	DNA-binding transcription factor activity
CLAM6_RS00100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CLAM6_RS00115	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CLAM6_RS00120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CLAM6_RS00125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CLAM6_RS00145	COG0006	proline dipeptidase activity
CLAM6_RS00150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLAM6_RS00155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLAM6_RS00160	COG0793	Belongs to the peptidase S41A family
CLAM6_RS00165	COG4942	peptidase
CLAM6_RS00170	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CLAM6_RS00175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CLAM6_RS00180	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CLAM6_RS00185	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CLAM6_RS00190	COG0189	ligase activity
CLAM6_RS00200	COG1678	Uncharacterized ACR, COG1678
CLAM6_RS00205	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CLAM6_RS00210	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CLAM6_RS00215	COG0540	Belongs to the ATCase OTCase family
CLAM6_RS00225	COG1942	4-Oxalocrotonate Tautomerase
CLAM6_RS00230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CLAM6_RS00235	COG1722	exodeoxyribonuclease VII activity
CLAM6_RS00240	COG0142	geranyltranstransferase activity
CLAM6_RS00245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CLAM6_RS00260	COG1272	protein, Hemolysin III
CLAM6_RS00265	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLAM6_RS00270	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CLAM6_RS00280	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CLAM6_RS00285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLAM6_RS00290	COG4597	amino acid ABC transporter
CLAM6_RS00295	COG0765	amino acid transport
CLAM6_RS00300	COG1126	abc transporter atp-binding protein
CLAM6_RS00320	COG0583	DNA-binding transcription factor activity
CLAM6_RS00335	COG0004	ammonium transporteR
CLAM6_RS00380	COG1230	cation diffusion facilitator family transporter
CLAM6_RS00385	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CLAM6_RS00385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CLAM6_RS00395	COG0789	Transcriptional regulator
CLAM6_RS00415	COG0789	Transcriptional regulator
CLAM6_RS00420	COG2217	Heavy metal translocating P-type atpase
CLAM6_RS00430	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CLAM6_RS00470	COG1959	2 iron, 2 sulfur cluster binding
CLAM6_RS00480	COG0606	chelatase, subunit chli
CLAM6_RS00490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLAM6_RS00505	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CLAM6_RS00515	COG2363	Small membrane protein
CLAM6_RS00530	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CLAM6_RS00535	COG2226	methyltransferase
CLAM6_RS00550	COG1999	signal sequence binding
CLAM6_RS00555	COG0545	Peptidyl-prolyl cis-trans isomerase
CLAM6_RS00565	COG0488	(ABC) transporter
CLAM6_RS00570	COG1187	pseudouridine synthase activity
CLAM6_RS00575	COG3321	synthase
CLAM6_RS00575	COG0604	alcohol dehydrogenase
CLAM6_RS00580	COG1238	metal cluster binding
CLAM6_RS00595	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLAM6_RS00600	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CLAM6_RS00605	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLAM6_RS00610	COG1490	D-aminoacyl-tRNA deacylase activity
CLAM6_RS00615	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CLAM6_RS00620	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLAM6_RS00645	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CLAM6_RS00655	COG1011	Hydrolase
CLAM6_RS00660	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CLAM6_RS00670	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CLAM6_RS00675	COG0019	diaminopimelate decarboxylase activity
CLAM6_RS00685	COG0165	Argininosuccinate lyase
CLAM6_RS00700	COG2959	enzyme of heme biosynthesis
CLAM6_RS00715	COG0668	transmembrane transport
CLAM6_RS00720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLAM6_RS00725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLAM6_RS00730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLAM6_RS00735	COG1120	ATPase activity
CLAM6_RS00745	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CLAM6_RS00750	COG2867	negative regulation of translational initiation
CLAM6_RS00755	COG2914	Belongs to the UPF0125 (RnfH) family
CLAM6_RS00760	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLAM6_RS00770	COG0497	DNA recombination
CLAM6_RS00775	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CLAM6_RS00780	COG0443	Heat shock 70 kDa protein
CLAM6_RS00785	COG0484	heat shock protein binding
CLAM6_RS00795	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CLAM6_RS00825	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CLAM6_RS00830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLAM6_RS00835	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CLAM6_RS00840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLAM6_RS00845	COG0149	triose-phosphate isomerase activity
CLAM6_RS00850	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CLAM6_RS00865	COG0779	Required for maturation of 30S ribosomal subunits
CLAM6_RS00870	COG0195	Participates in both transcription termination and antitermination
CLAM6_RS00875	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CLAM6_RS00880	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CLAM6_RS00885	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CLAM6_RS00890	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CLAM6_RS00895	COG1185	polyribonucleotide nucleotidyltransferase activity
CLAM6_RS00905	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CLAM6_RS00910	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CLAM6_RS00915	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CLAM6_RS00925	COG0617	tRNA 3'-terminal CCA addition
CLAM6_RS00945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLAM6_RS00950	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CLAM6_RS00955	COG0436	Aminotransferase
CLAM6_RS00960	COG1489	DNA binding
CLAM6_RS00975	COG1607	acyl-coa hydrolase
CLAM6_RS00980	COG2813	Specifically methylates the guanine in position
CLAM6_RS00980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CLAM6_RS00985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CLAM6_RS01015	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CLAM6_RS01020	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CLAM6_RS01040	COG0346	lactoylglutathione lyase activity
CLAM6_RS01045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLAM6_RS01050	COG1902	pentaerythritol trinitrate reductase activity
CLAM6_RS01075	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CLAM6_RS01090	COG3068	Protein conserved in bacteria
CLAM6_RS01100	COG0107	imidazoleglycerol-phosphate synthase activity
CLAM6_RS01105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CLAM6_RS01110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CLAM6_RS01115	COG0131	Imidazoleglycerol-phosphate dehydratase
CLAM6_RS01130	COG1194	a g-specific adenine glycosylase
CLAM6_RS01135	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CLAM6_RS01165	COG2204	response regulator
CLAM6_RS01180	COG1462	curli production assembly transport component CsgG
CLAM6_RS01185	COG5285	phytanoyl-CoA dioxygenase
CLAM6_RS01190	COG0179	Fumarylacetoacetate (FAA) hydrolase
CLAM6_RS01195	COG1166	arginine decarboxylase activity
CLAM6_RS01220	COG2204	response regulator
CLAM6_RS01225	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CLAM6_RS01235	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLAM6_RS01245	COG2175	clavaminate synthase activity
CLAM6_RS01315	COG1444	tRNA N-acetyltransferase activity
CLAM6_RS01320	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLAM6_RS01330	COG0693	protein deglycase activity
CLAM6_RS01345	COG3220	belongs to the UPF0276 family
CLAM6_RS01355	COG2259	Doxx family
CLAM6_RS01365	COG0783	Belongs to the Dps family
CLAM6_RS01370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLAM6_RS01385	COG4191	Histidine kinase
CLAM6_RS01445	COG0583	DNA-binding transcription factor activity
CLAM6_RS01450	COG1054	Belongs to the UPF0176 family
CLAM6_RS01455	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CLAM6_RS01460	COG0243	molybdopterin cofactor binding
CLAM6_RS01465	COG0346	lactoylglutathione lyase activity
CLAM6_RS01470	COG3706	GGDEF domain
CLAM6_RS01475	COG0671	phosphoesterase, PA-phosphatase related
CLAM6_RS01485	COG0525	valine-tRNA ligase activity
CLAM6_RS01490	COG0784	Response regulator, receiver
CLAM6_RS01490	COG2205	protein histidine kinase activity
CLAM6_RS01500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLAM6_RS01505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CLAM6_RS01510	COG0795	lipopolysaccharide-transporting ATPase activity
CLAM6_RS01515	COG0795	lipopolysaccharide-transporting ATPase activity
CLAM6_RS01560	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CLAM6_RS01575	COG3220	belongs to the UPF0276 family
CLAM6_RS01590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLAM6_RS01605	COG3278	Belongs to the heme-copper respiratory oxidase family
CLAM6_RS01640	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLAM6_RS01640	COG1902	pentaerythritol trinitrate reductase activity
CLAM6_RS01655	COG2766	serine protein kinase
CLAM6_RS01660	COG2718	Belongs to the UPF0229 family
CLAM6_RS01665	COG2719	SpoVR family
CLAM6_RS01700	COG0557	exoribonuclease II activity
CLAM6_RS01705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLAM6_RS01710	COG0360	Binds together with S18 to 16S ribosomal RNA
CLAM6_RS01715	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CLAM6_RS01725	COG0359	binds to the 23S rRNA
CLAM6_RS01730	COG0305	Participates in initiation and elongation during chromosome replication
CLAM6_RS01740	COG2200	EAL domain
CLAM6_RS01740	COG2199	diguanylate cyclase activity
CLAM6_RS01740	COG2203	Gaf domain
CLAM6_RS01755	COG3046	protein related to deoxyribodipyrimidine photolyase
CLAM6_RS01760	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CLAM6_RS01765	COG1320	monovalent cation:proton antiporter activity
CLAM6_RS01770	COG2212	antiporter activity
CLAM6_RS01775	COG1863	multisubunit Na H antiporter MnhE subunit
CLAM6_RS01780	COG0651	ATP synthesis coupled electron transport
CLAM6_RS01785	COG1006	Multisubunit Na H antiporter MnhC subunit
CLAM6_RS01790	COG2111	Na H antiporter
CLAM6_RS01790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CLAM6_RS01800	COG0415	Belongs to the DNA photolyase family
CLAM6_RS01815	COG0151	Belongs to the GarS family
CLAM6_RS01825	COG3954	Phosphoribulokinase
CLAM6_RS01835	COG0537	adenosine 5'-monophosphoramidase activity
CLAM6_RS01840	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CLAM6_RS01865	COG3850	Histidine kinase
CLAM6_RS01865	COG0642	Histidine kinase
CLAM6_RS01870	COG0666	response to abiotic stimulus
CLAM6_RS01885	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CLAM6_RS01890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLAM6_RS01895	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLAM6_RS01895	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CLAM6_RS01900	COG0745	RESPONSE REGULATOR receiver
CLAM6_RS01905	COG2205	protein histidine kinase activity
CLAM6_RS01915	COG1278	Cold shock
CLAM6_RS01920	COG0583	DNA-binding transcription factor activity
CLAM6_RS01935	COG1739	Uncharacterized protein family UPF0029
CLAM6_RS01965	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CLAM6_RS01970	COG1138	Cytochrome C-type biogenesis protein
CLAM6_RS01975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLAM6_RS01995	COG3115	cell septum assembly
CLAM6_RS02000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CLAM6_RS02015	COG3290	protein histidine kinase activity
CLAM6_RS02020	COG4565	transcriptional regulatory protein
CLAM6_RS02025	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CLAM6_RS02025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLAM6_RS02030	COG2350	Protein conserved in bacteria
CLAM6_RS02035	COG2917	probably involved in intracellular septation
CLAM6_RS02040	COG0613	PHP domain protein
CLAM6_RS02045	COG0009	L-threonylcarbamoyladenylate synthase
CLAM6_RS02050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLAM6_RS02060	COG1392	Phosphate transport regulator
CLAM6_RS02065	COG0306	phosphate transporter
CLAM6_RS02070	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CLAM6_RS02070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CLAM6_RS02075	COG2205	protein histidine kinase activity
CLAM6_RS02085	COG2204	response regulator
CLAM6_RS02100	COG0519	Catalyzes the synthesis of GMP from XMP
CLAM6_RS02100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CLAM6_RS02155	COG0513	Belongs to the DEAD box helicase family
CLAM6_RS02165	COG2223	nitrite transmembrane transporter activity
CLAM6_RS02170	COG0745	RESPONSE REGULATOR receiver
CLAM6_RS02175	COG1116	anion transmembrane transporter activity
CLAM6_RS02175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CLAM6_RS02180	COG1309	transcriptional regulator
CLAM6_RS02210	COG1953	Uracil, thiamine, allantoin
CLAM6_RS02215	COG0583	DNA-binding transcription factor activity
CLAM6_RS02235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CLAM6_RS02250	COG1902	pentaerythritol trinitrate reductase activity
CLAM6_RS02250	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLAM6_RS02255	COG2181	nitrate reductase activity
CLAM6_RS02255	COG0247	lactate metabolic process
CLAM6_RS02260	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CLAM6_RS02280	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLAM6_RS02290	COG3383	formate dehydrogenase (NAD+) activity
CLAM6_RS02300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLAM6_RS02305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CLAM6_RS02310	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CLAM6_RS02315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CLAM6_RS02320	COG1845	cytochrome c oxidase, subunit III
CLAM6_RS02325	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CLAM6_RS02330	COG0109	protoheme IX farnesyltransferase activity
CLAM6_RS02340	COG1017	nitric oxide dioxygenase activity
CLAM6_RS02340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CLAM6_RS02345	COG1757	Na H antiporter
CLAM6_RS02355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLAM6_RS02395	COG1120	ATPase activity
CLAM6_RS02405	COG4264	IucA IucC family
CLAM6_RS02410	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CLAM6_RS02415	COG0076	glutamate decarboxylase activity
CLAM6_RS02455	COG0739	heme binding
CLAM6_RS02460	COG0583	DNA-binding transcription factor activity
CLAM6_RS02465	COG0435	Glutathione S-transferase
CLAM6_RS02485	COG1515	deoxyribonuclease V activity
CLAM6_RS02495	COG0420	3'-5' exonuclease activity
CLAM6_RS02510	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CLAM6_RS02515	COG1074	ATP-dependent DNA helicase activity
CLAM6_RS02520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLAM6_RS02530	COG2205	protein histidine kinase activity
CLAM6_RS02535	COG1914	H( )-stimulated, divalent metal cation uptake system
CLAM6_RS02555	COG3871	stress protein (general stress protein 26)
CLAM6_RS02580	COG3104	oligopeptide transport
CLAM6_RS02585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLAM6_RS02590	COG1309	transcriptional regulator
CLAM6_RS02605	COG0583	DNA-binding transcription factor activity
CLAM6_RS02615	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CLAM6_RS02620	COG4988	ABC transporter
CLAM6_RS02625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLAM6_RS02640	COG2084	Dehydrogenase
CLAM6_RS02655	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CLAM6_RS02660	COG1053	succinate dehydrogenase
CLAM6_RS02685	COG0045	succinate-CoA ligase (ADP-forming) activity
CLAM6_RS02700	COG0584	glycerophosphoryl diester phosphodiesterase
CLAM6_RS02715	COG0438	transferase activity, transferring glycosyl groups
CLAM6_RS02725	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CLAM6_RS02735	COG0673	inositol 2-dehydrogenase activity
CLAM6_RS02740	COG3768	UPF0283 membrane protein
CLAM6_RS02745	COG3106	COG3106 Predicted ATPase
CLAM6_RS02750	COG2814	Major facilitator Superfamily
CLAM6_RS02760	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLAM6_RS02765	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLAM6_RS02810	COG0121	glutamine amidotransferase
CLAM6_RS02820	COG0318	PFAM AMP-dependent synthetase and ligase
CLAM6_RS02825	COG1643	Atp-dependent helicase
CLAM6_RS02835	COG2853	Lipoprotein
CLAM6_RS02855	COG2814	Major facilitator Superfamily
CLAM6_RS02865	COG0573	inorganic phosphate transmembrane transporter activity
CLAM6_RS02870	COG0573	inorganic phosphate transmembrane transporter activity
CLAM6_RS02875	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLAM6_RS02880	COG0183	Belongs to the thiolase family
CLAM6_RS02885	COG1309	transcriptional regulator
CLAM6_RS02890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CLAM6_RS02900	COG1960	acyl-CoA dehydrogenase activity
CLAM6_RS02905	COG0628	permease
CLAM6_RS02910	COG3118	belongs to the thioredoxin family
CLAM6_RS02915	COG0730	response to heat
CLAM6_RS02920	COG0583	DNA-binding transcription factor activity
CLAM6_RS02925	COG0175	sulfate reduction
CLAM6_RS02940	COG1802	Transcriptional regulator
CLAM6_RS02945	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CLAM6_RS02950	COG0372	Belongs to the citrate synthase family
CLAM6_RS02955	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CLAM6_RS02965	COG2079	MmgE PrpD family protein
CLAM6_RS02970	COG1704	LemA family
CLAM6_RS02975	COG0501	Belongs to the peptidase M48B family
CLAM6_RS03005	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CLAM6_RS03030	COG3101	peptidyl-lysine hydroxylation
CLAM6_RS03035	COG1840	ABC-type Fe3 transport system, periplasmic component
CLAM6_RS03040	COG4208	sulfate ABC transporter
CLAM6_RS03050	COG0513	Belongs to the DEAD box helicase family
CLAM6_RS03065	COG0488	(ABC) transporter
CLAM6_RS03070	COG0589	response to stress
CLAM6_RS03090	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLAM6_RS03090	COG1024	Enoyl-CoA hydratase
CLAM6_RS03095	COG0183	Belongs to the thiolase family
CLAM6_RS03105	COG1466	dna polymerase III delta subunit
CLAM6_RS03115	COG0495	leucyl-tRNA aminoacylation
CLAM6_RS03140	COG4535	Mg2 and Co2 transporter CorC
CLAM6_RS03145	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CLAM6_RS03150	COG1702	phosphate starvation-inducible protein PhoH
CLAM6_RS03155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLAM6_RS03160	COG4991	sh3 domain protein
CLAM6_RS03165	COG0500	methyltransferase
CLAM6_RS03180	COG0405	Gamma-glutamyltransferase
CLAM6_RS03185	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CLAM6_RS03190	COG2827	Endonuclease containing a URI domain
CLAM6_RS03195	COG1252	NADH dehydrogenase
CLAM6_RS03200	COG0546	phosphoglycolate phosphatase activity
CLAM6_RS03215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLAM6_RS03220	COG0134	indole-3-glycerol-phosphate synthase activity
CLAM6_RS03235	COG1349	DNA-binding transcription factor activity
CLAM6_RS03245	COG3842	ATPase activity
CLAM6_RS03250	COG0395	ABC-type sugar transport system, permease component
CLAM6_RS03275	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CLAM6_RS03320	COG1362	aminopeptidase activity
CLAM6_RS03335	COG0583	DNA-binding transcription factor activity
CLAM6_RS03345	COG0193	aminoacyl-tRNA hydrolase activity
CLAM6_RS03350	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CLAM6_RS03365	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CLAM6_RS03370	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CLAM6_RS03380	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CLAM6_RS03385	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CLAM6_RS03390	COG2890	protein-(glutamine-N5) methyltransferase activity
CLAM6_RS03400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CLAM6_RS03405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLAM6_RS03410	COG3842	ATPase activity
CLAM6_RS03415	COG1176	ABC-type spermidine putrescine transport system, permease component I
CLAM6_RS03420	COG1177	transmembrane transport
CLAM6_RS03425	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CLAM6_RS03440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLAM6_RS03445	COG1757	Na H antiporter
CLAM6_RS03450	COG0174	glutamine synthetase
CLAM6_RS03455	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CLAM6_RS03465	COG1012	belongs to the aldehyde dehydrogenase family
CLAM6_RS03475	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLAM6_RS03480	COG0154	amidase activity
CLAM6_RS03485	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLAM6_RS03490	COG1077	Cell shape determining protein MreB Mrl
CLAM6_RS03495	COG1792	Involved in formation and maintenance of cell shape
CLAM6_RS03500	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CLAM6_RS03505	COG0424	maF-like protein
CLAM6_RS03510	COG1530	ribonuclease E activity
CLAM6_RS03520	COG0312	modulator of DNA gyrase
CLAM6_RS03525	COG3028	Belongs to the UPF0307 family
CLAM6_RS03530	COG0312	modulator of DNA gyrase
CLAM6_RS03535	COG2239	Acts as a magnesium transporter
CLAM6_RS03540	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLAM6_RS03545	COG1660	Displays ATPase and GTPase activities
CLAM6_RS03560	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CLAM6_RS03565	COG1137	ATPase activity
CLAM6_RS03570	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CLAM6_RS03580	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CLAM6_RS03595	COG1127	ABC transporter
CLAM6_RS03600	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CLAM6_RS03605	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CLAM6_RS03620	COG5007	Belongs to the BolA IbaG family
CLAM6_RS03625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLAM6_RS03630	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CLAM6_RS03635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CLAM6_RS03640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLAM6_RS03655	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CLAM6_RS03660	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CLAM6_RS03665	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CLAM6_RS03670	COG0723	plastoquinol--plastocyanin reductase activity
CLAM6_RS03675	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CLAM6_RS03680	COG2857	Cytochrome c1
CLAM6_RS03685	COG0625	glutathione transferase activity
CLAM6_RS03690	COG2969	positive regulation of protein catabolic process
CLAM6_RS03695	COG2823	Periplasmic or secreted lipoprotein
CLAM6_RS03700	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CLAM6_RS03705	COG0792	nuclease activity
CLAM6_RS03725	COG0275	rRNA processing
CLAM6_RS03745	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLAM6_RS03750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLAM6_RS03755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CLAM6_RS03760	COG0772	Belongs to the SEDS family
CLAM6_RS03765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLAM6_RS03770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLAM6_RS03775	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLAM6_RS03795	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CLAM6_RS03810	COG0653	protein targeting
CLAM6_RS03815	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CLAM6_RS03820	COG0352	thiamine-phosphate diphosphorylase activity
CLAM6_RS03870	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CLAM6_RS03870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CLAM6_RS03875	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CLAM6_RS03880	COG1737	Transcriptional regulator
CLAM6_RS03905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLAM6_RS03915	COG2040	homocysteine
CLAM6_RS03920	COG0653	protein targeting
CLAM6_RS03935	COG1215	transferase activity, transferring glycosyl groups
CLAM6_RS03940	COG2244	polysaccharide biosynthetic process
CLAM6_RS03965	COG2814	Major facilitator Superfamily
CLAM6_RS03970	COG0250	Participates in transcription elongation, termination and antitermination
CLAM6_RS03975	COG1047	Peptidyl-prolyl cis-trans
CLAM6_RS03985	COG0284	orotidine-5'-phosphate decarboxylase activity
CLAM6_RS03995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLAM6_RS04000	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CLAM6_RS04005	COG4206	TonB-dependent receptor
CLAM6_RS04010	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CLAM6_RS04020	COG0247	lactate metabolic process
CLAM6_RS04020	COG0277	FAD linked oxidase domain protein
CLAM6_RS04030	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CLAM6_RS04035	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CLAM6_RS04040	COG1648	precorrin-2 dehydrogenase activity
CLAM6_RS04040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CLAM6_RS04045	COG1960	acyl-CoA dehydrogenase activity
CLAM6_RS04055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLAM6_RS04060	COG1742	UPF0060 membrane protein
CLAM6_RS04075	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CLAM6_RS04080	COG1073	alpha beta
CLAM6_RS04080	COG2226	methyltransferase
CLAM6_RS04085	COG0596	Alpha beta hydrolase
CLAM6_RS04090	COG0156	8-amino-7-oxononanoate synthase activity
CLAM6_RS04095	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLAM6_RS04100	COG1040	competence protein
CLAM6_RS04105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CLAM6_RS04110	COG0302	gtp cyclohydrolase
CLAM6_RS04115	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CLAM6_RS04130	COG2066	Belongs to the glutaminase family
CLAM6_RS04145	COG0138	bifunctional purine biosynthesis protein purh
CLAM6_RS04160	COG2264	protein methyltransferase activity
CLAM6_RS04170	COG0511	ligase activity, forming carbon-carbon bonds
CLAM6_RS04175	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CLAM6_RS04200	COG0702	epimerase
CLAM6_RS04205	COG0205	6-phosphofructokinase activity
CLAM6_RS04210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLAM6_RS04230	COG0586	Pfam SNARE associated Golgi protein
CLAM6_RS04245	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CLAM6_RS04250	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CLAM6_RS04260	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CLAM6_RS04265	COG0768	penicillin binding
CLAM6_RS04270	COG0772	Belongs to the SEDS family
CLAM6_RS04275	COG2951	lytic endotransglycosylase activity
CLAM6_RS04280	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CLAM6_RS04285	COG1686	Belongs to the peptidase S11 family
CLAM6_RS04290	COG2921	Belongs to the UPF0250 family
CLAM6_RS04295	COG0321	lipoyl(octanoyl) transferase activity
CLAM6_RS04300	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CLAM6_RS04310	COG0439	Biotin carboxylase
CLAM6_RS04325	COG1028	Short-chain dehydrogenase reductase Sdr
CLAM6_RS04340	COG1803	Methylglyoxal synthase
CLAM6_RS04345	COG0469	pyruvate kinase activity
CLAM6_RS04365	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLAM6_RS04370	COG1309	transcriptional regulator
CLAM6_RS04375	COG1376	ErfK ybiS ycfS ynhG family protein
CLAM6_RS04380	COG1472	Belongs to the glycosyl hydrolase 3 family
CLAM6_RS04385	COG0668	transmembrane transport
CLAM6_RS04390	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CLAM6_RS04400	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CLAM6_RS04410	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CLAM6_RS04415	COG1805	sodium ion transport
CLAM6_RS04430	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CLAM6_RS04435	COG2871	sodium ion transport
CLAM6_RS04440	COG1477	protein flavinylation
CLAM6_RS04450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLAM6_RS04465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLAM6_RS04470	COG2957	Belongs to the agmatine deiminase family
CLAM6_RS04475	COG4591	ABC-type transport system involved in lipoprotein release permease component
CLAM6_RS04480	COG1136	(ABC) transporter
CLAM6_RS04495	COG0811	peptide transport
CLAM6_RS04500	COG0848	biopolymer transport protein
CLAM6_RS04505	COG1132	(ABC) transporter
CLAM6_RS04510	COG1663	tetraacyldisaccharide 4'-kinase activity
CLAM6_RS04515	COG2835	tetraacyldisaccharide 4'-kinase activity
CLAM6_RS04520	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CLAM6_RS04530	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CLAM6_RS04535	COG1530	ribonuclease E activity
CLAM6_RS04545	COG0546	phosphoglycolate phosphatase activity
CLAM6_RS04550	COG0616	signal peptide processing
CLAM6_RS04550	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CLAM6_RS04555	COG0424	maF-like protein
CLAM6_RS04560	COG1399	metal-binding, possibly nucleic acid-binding protein
CLAM6_RS04565	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CLAM6_RS04570	COG0416	fatty acid biosynthetic process
CLAM6_RS04575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CLAM6_RS04585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLAM6_RS04590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLAM6_RS04595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLAM6_RS04600	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CLAM6_RS04605	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CLAM6_RS04620	COG0084	hydrolase, TatD family'
CLAM6_RS04640	COG1301	dicarboxylic acid transport
CLAM6_RS04675	COG0848	biopolymer transport protein
CLAM6_RS04690	COG0708	Exodeoxyribonuclease III
CLAM6_RS04705	COG1199	ATP-dependent helicase activity
CLAM6_RS04710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CLAM6_RS04725	COG4628	conserved protein (DUF2132)
CLAM6_RS04735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLAM6_RS04740	COG0481	GTPase activity
CLAM6_RS04745	COG0681	Belongs to the peptidase S26 family
CLAM6_RS04750	COG0571	ribonuclease III activity
CLAM6_RS04755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CLAM6_RS04760	COG1381	Involved in DNA repair and RecF pathway recombination
CLAM6_RS04775	COG0784	Response regulator, receiver
CLAM6_RS04775	COG2205	protein histidine kinase activity
CLAM6_RS04775	COG5002	protein histidine kinase activity
CLAM6_RS04785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CLAM6_RS04790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLAM6_RS04795	COG3956	TIGRFAM MazG family protein
CLAM6_RS04800	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CLAM6_RS04805	COG0252	asparaginase activity
CLAM6_RS04810	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CLAM6_RS04825	COG2807	transmembrane transport
CLAM6_RS04855	COG3134	Outer membrane lipoprotein
CLAM6_RS04865	COG3008	intermembrane lipid transfer
CLAM6_RS04865	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CLAM6_RS04870	COG2995	paraquat-inducible protein a
CLAM6_RS04875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLAM6_RS04880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLAM6_RS04895	COG1966	Carbon starvation protein
CLAM6_RS04900	COG1565	acr, cog1565
CLAM6_RS04900	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CLAM6_RS04910	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CLAM6_RS04950	COG2814	Major facilitator Superfamily
CLAM6_RS04955	COG1597	lipid kinase activity
CLAM6_RS04965	COG0330	HflC and HflK could
CLAM6_RS04980	COG1278	Cold shock
CLAM6_RS05025	COG0741	lytic transglycosylase activity
CLAM6_RS05030	COG3339	Conserved Protein
CLAM6_RS05050	COG0326	Molecular chaperone. Has ATPase activity
CLAM6_RS05065	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CLAM6_RS05075	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CLAM6_RS05085	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CLAM6_RS05100	COG1131	(ABC) transporter
CLAM6_RS05120	COG0596	Alpha beta hydrolase
CLAM6_RS05145	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CLAM6_RS05160	COG3243	poly(R)-hydroxyalkanoic acid synthase
CLAM6_RS05170	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLAM6_RS05175	COG0066	3-isopropylmalate dehydratase activity
CLAM6_RS05180	COG0473	3-isopropylmalate dehydrogenase activity
CLAM6_RS05195	COG0101	tRNA pseudouridine synthase activity
CLAM6_RS05200	COG0135	phosphoribosylanthranilate isomerase activity
CLAM6_RS05205	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CLAM6_RS05210	COG0285	dihydrofolate synthase activity
CLAM6_RS05235	COG3038	cytochrome b561
CLAM6_RS05240	COG2353	YceI-like domain
CLAM6_RS05245	COG1280	lysine exporter protein (LysE YggA)
CLAM6_RS05265	COG0133	tryptophan synthase activity
CLAM6_RS05270	COG0159	tryptophan synthase activity
CLAM6_RS05290	COG0438	transferase activity, transferring glycosyl groups
CLAM6_RS05295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CLAM6_RS05300	COG2813	Specifically methylates the guanine in position
CLAM6_RS05305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLAM6_RS05315	COG0494	nUDIX hydrolase
CLAM6_RS05320	COG3151	Protein conserved in bacteria
CLAM6_RS05325	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CLAM6_RS05330	COG0175	sulfate reduction
CLAM6_RS05335	COG2895	sulfate adenylyltransferase (ATP) activity
CLAM6_RS05340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CLAM6_RS05340	COG1017	nitric oxide dioxygenase activity
CLAM6_RS05345	COG3604	Transcriptional regulator
CLAM6_RS05350	COG0500	methyltransferase
CLAM6_RS05355	COG4106	trans-aconitate 2-methyltransferase activity
CLAM6_RS05360	COG0166	Belongs to the GPI family
CLAM6_RS05365	COG3150	esterase
CLAM6_RS05380	COG3830	Belongs to the UPF0237 family
CLAM6_RS05380	COG0560	Phosphoserine phosphatase
CLAM6_RS05400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CLAM6_RS05405	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CLAM6_RS05410	COG0688	phosphatidylethanolamine metabolic process
CLAM6_RS05420	COG2252	PERMEase
CLAM6_RS05425	COG1162	GTPase activity
CLAM6_RS05430	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CLAM6_RS05440	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CLAM6_RS05440	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CLAM6_RS05445	COG0802	atpase or kinase
CLAM6_RS05450	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLAM6_RS05465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CLAM6_RS05470	COG1923	regulation of RNA biosynthetic process
CLAM6_RS05475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CLAM6_RS05480	COG0330	HflC and HflK could
CLAM6_RS05485	COG0330	HflC and HflK could
CLAM6_RS05490	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CLAM6_RS05495	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CLAM6_RS05500	COG1959	2 iron, 2 sulfur cluster binding
CLAM6_RS05505	COG0719	Fe-S assembly protein
CLAM6_RS05510	COG0396	ATPase activity
CLAM6_RS05515	COG0719	Fe-S assembly protein
CLAM6_RS05545	COG0189	ligase activity
CLAM6_RS05570	COG1126	abc transporter atp-binding protein
CLAM6_RS05640	COG0400	carboxylic ester hydrolase activity
CLAM6_RS05655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLAM6_RS05665	COG3047	cAMP biosynthetic process
CLAM6_RS05685	COG1294	oxidase, subunit
CLAM6_RS05690	COG4890	Cyd operon protein YbgT
CLAM6_RS05700	COG0463	Glycosyl transferase, family 2
CLAM6_RS05720	COG0668	transmembrane transport
CLAM6_RS05750	COG1414	Transcriptional regulator
CLAM6_RS05780	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CLAM6_RS05830	COG1280	lysine exporter protein (LysE YggA)
CLAM6_RS05855	COG1653	transport
CLAM6_RS05860	COG1175	transmembrane transport
CLAM6_RS05870	COG3842	ATPase activity
CLAM6_RS05875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLAM6_RS05890	COG1070	Carbohydrate kinase
CLAM6_RS05895	COG0667	Aldo Keto reductase
CLAM6_RS05905	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CLAM6_RS05910	COG0247	lactate metabolic process
CLAM6_RS05915	COG0277	FAD linked oxidase domain protein
CLAM6_RS05920	COG0277	FAD linked oxidase domain protein
CLAM6_RS05925	COG2186	Transcriptional regulator
CLAM6_RS05935	COG3048	D-serine ammonia-lyase activity
CLAM6_RS05940	COG0517	IMP dehydrogenase activity
CLAM6_RS05940	COG0617	tRNA 3'-terminal CCA addition
CLAM6_RS05940	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CLAM6_RS05950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CLAM6_RS05950	COG0678	peroxiredoxin activity
CLAM6_RS05965	COG3842	ATPase activity
CLAM6_RS05975	COG1176	ABC-type spermidine putrescine transport system, permease component I
CLAM6_RS05985	COG3284	Transcriptional regulator
CLAM6_RS05990	COG3842	ATPase activity
CLAM6_RS05995	COG3842	ATPase activity
CLAM6_RS06005	COG0395	ABC-type sugar transport system, permease component
CLAM6_RS06025	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLAM6_RS06025	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLAM6_RS06030	COG0509	glycine decarboxylation via glycine cleavage system
CLAM6_RS06035	COG1115	amino acid carrier protein
CLAM6_RS06040	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CLAM6_RS06045	COG1278	Cold shock
CLAM6_RS06050	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CLAM6_RS06055	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CLAM6_RS06060	COG0583	DNA-binding transcription factor activity
CLAM6_RS06085	COG0204	Acyl-transferase
CLAM6_RS06090	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CLAM6_RS06115	COG2855	membrane
CLAM6_RS06120	COG0583	DNA-binding transcription factor activity
CLAM6_RS06125	COG0596	Alpha beta hydrolase
CLAM6_RS06135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CLAM6_RS06140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLAM6_RS06145	COG1116	anion transmembrane transporter activity
CLAM6_RS06155	COG3263	regulation of cellular component size
CLAM6_RS06165	COG0513	Belongs to the DEAD box helicase family
CLAM6_RS06185	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CLAM6_RS06200	COG2920	part of a sulfur-relay system
CLAM6_RS06205	COG0217	transcriptional regulatory protein
CLAM6_RS06215	COG0189	ligase activity
CLAM6_RS06215	COG4067	protein conserved in archaea
CLAM6_RS06230	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CLAM6_RS06235	COG0463	Glycosyl transferase, family 2
CLAM6_RS06270	COG1764	response to oxidative stress
CLAM6_RS06275	COG1295	ribonuclease BN
CLAM6_RS06295	COG1187	pseudouridine synthase activity
CLAM6_RS06305	COG1301	dicarboxylic acid transport
CLAM6_RS06315	COG0583	DNA-binding transcription factor activity
CLAM6_RS06345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CLAM6_RS06370	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CLAM6_RS06375	COG0583	DNA-binding transcription factor activity
CLAM6_RS06380	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CLAM6_RS06385	COG1473	amidohydrolase
CLAM6_RS06420	COG2826	transposase and inactivated derivatives, IS30 family
CLAM6_RS06450	COG3284	Transcriptional regulator
CLAM6_RS06490	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CLAM6_RS06505	COG3550	peptidyl-serine autophosphorylation
CLAM6_RS06510	COG1396	sequence-specific DNA binding
CLAM6_RS06535	COG2826	transposase and inactivated derivatives, IS30 family
CLAM6_RS06575	COG0583	DNA-binding transcription factor activity
CLAM6_RS06590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CLAM6_RS06595	COG4771	TonB-dependent receptor
CLAM6_RS06600	COG4607	ABC-type enterochelin transport system periplasmic component
CLAM6_RS06665	COG1902	pentaerythritol trinitrate reductase activity
CLAM6_RS06680	COG1012	belongs to the aldehyde dehydrogenase family
CLAM6_RS06685	COG1764	response to oxidative stress
CLAM6_RS06690	COG1979	alcohol dehydrogenase
CLAM6_RS06755	COG1840	ABC-type Fe3 transport system, periplasmic component
CLAM6_RS06760	COG3842	ATPase activity
CLAM6_RS06765	COG0395	ABC-type sugar transport system, permease component
CLAM6_RS06770	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CLAM6_RS06800	COG1396	sequence-specific DNA binding
CLAM6_RS06805	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CLAM6_RS06815	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLAM6_RS06855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLAM6_RS06880	COG2175	clavaminate synthase activity
CLAM6_RS06890	COG0583	DNA-binding transcription factor activity
CLAM6_RS06895	COG3321	synthase
CLAM6_RS06895	COG0604	alcohol dehydrogenase
CLAM6_RS06900	COG4221	oxidoreductase activity
CLAM6_RS06925	COG1944	ATP diphosphatase activity
CLAM6_RS06945	COG1120	ATPase activity
CLAM6_RS06950	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLAM6_RS06955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLAM6_RS06975	COG0439	Biotin carboxylase
CLAM6_RS06990	COG1116	anion transmembrane transporter activity
CLAM6_RS07010	COG1204	response to ionizing radiation
CLAM6_RS07015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLAM6_RS07030	COG0583	DNA-binding transcription factor activity
CLAM6_RS07040	COG2076	Multidrug Resistance protein
CLAM6_RS07045	COG2076	Multidrug Resistance protein
CLAM6_RS07060	COG2197	response regulator
CLAM6_RS07065	COG3850	Histidine kinase
CLAM6_RS07070	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CLAM6_RS07075	COG0004	ammonium transporteR
CLAM6_RS07085	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CLAM6_RS07090	COG0546	phosphoglycolate phosphatase activity
CLAM6_RS07100	COG3036	rescue of stalled ribosome
CLAM6_RS07105	COG1902	pentaerythritol trinitrate reductase activity
CLAM6_RS07110	COG0583	DNA-binding transcription factor activity
CLAM6_RS07130	COG1253	flavin adenine dinucleotide binding
CLAM6_RS07150	COG2828	Protein conserved in bacteria
CLAM6_RS07155	COG0583	DNA-binding transcription factor activity
CLAM6_RS07180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLAM6_RS07200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLAM6_RS07220	COG1999	signal sequence binding
CLAM6_RS07240	COG2957	Belongs to the agmatine deiminase family
CLAM6_RS07245	COG1757	Na H antiporter
CLAM6_RS07250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CLAM6_RS07260	COG1012	belongs to the aldehyde dehydrogenase family
CLAM6_RS07270	COG2249	NAD(P)H dehydrogenase (quinone) activity
CLAM6_RS07290	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CLAM6_RS07310	COG1609	Transcriptional regulator
CLAM6_RS07320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLAM6_RS07335	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CLAM6_RS07345	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CLAM6_RS07350	COG2218	PFAM glutamate synthase alpha subunit domain protein
CLAM6_RS07355	COG0069	glutamate synthase activity
CLAM6_RS07365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CLAM6_RS07375	COG0004	ammonium transporteR
CLAM6_RS07390	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CLAM6_RS07390	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLAM6_RS07405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CLAM6_RS07430	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CLAM6_RS07435	COG3639	organic phosphonate transmembrane transporter activity
CLAM6_RS07445	COG0583	DNA-binding transcription factor activity
CLAM6_RS07465	COG0604	alcohol dehydrogenase
CLAM6_RS07495	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLAM6_RS07515	COG4336	lyase activity
CLAM6_RS07530	COG0583	DNA-binding transcription factor activity
CLAM6_RS07535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLAM6_RS07545	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLAM6_RS07550	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CLAM6_RS07560	COG1802	Transcriptional regulator
CLAM6_RS07565	COG1252	NADH dehydrogenase
CLAM6_RS07620	COG1902	pentaerythritol trinitrate reductase activity
CLAM6_RS07625	COG0697	spore germination
CLAM6_RS07630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CLAM6_RS07635	COG0235	Class ii aldolase
CLAM6_RS07655	COG0583	DNA-binding transcription factor activity
CLAM6_RS07660	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CLAM6_RS07665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CLAM6_RS07670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLAM6_RS07675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLAM6_RS07685	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CLAM6_RS07685	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLAM6_RS07690	COG1794	racemase activity, acting on amino acids and derivatives
CLAM6_RS07695	COG2207	Transcriptional regulator
CLAM6_RS07700	COG2807	transmembrane transport
CLAM6_RS07735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLAM6_RS07740	COG4172	Belongs to the ABC transporter superfamily
CLAM6_RS07750	COG5006	permease, DMT superfamily
CLAM6_RS07760	COG1757	Na H antiporter
CLAM6_RS07780	COG1971	Probably functions as a manganese efflux pump
CLAM6_RS07785	COG0625	glutathione transferase activity
CLAM6_RS07790	COG0604	alcohol dehydrogenase
CLAM6_RS07790	COG1028	Short-chain dehydrogenase reductase Sdr
CLAM6_RS07790	COG3321	synthase
CLAM6_RS07805	COG0583	DNA-binding transcription factor activity
CLAM6_RS07810	COG3437	response regulator, receiver
CLAM6_RS07810	COG2770	Histidine kinase
CLAM6_RS07825	COG0583	DNA-binding transcription factor activity
CLAM6_RS07835	COG0431	NADPH-dependent FMN reductase
CLAM6_RS07840	COG1393	Belongs to the ArsC family
CLAM6_RS07845	COG0640	Transcriptional regulator
CLAM6_RS07860	COG3530	Putative quorum-sensing-regulated virulence factor
CLAM6_RS07925	COG0417	DNA replication proofreading
CLAM6_RS07930	COG4615	Cyclic peptide transporter
CLAM6_RS07960	COG4172	Belongs to the ABC transporter superfamily
CLAM6_RS07965	COG4239	(ABC) transporter, permease
CLAM6_RS07970	COG4174	ABC transporter (Permease)
CLAM6_RS07975	COG4166	transmembrane transport
CLAM6_RS07980	COG1388	LysM domain
CLAM6_RS07980	COG0741	lytic transglycosylase activity
CLAM6_RS07985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLAM6_RS07990	COG2226	methyltransferase
CLAM6_RS07995	COG0328	RNA-DNA hybrid ribonuclease activity
CLAM6_RS08015	COG0616	signal peptide processing
CLAM6_RS08020	COG0640	Transcriptional regulator
CLAM6_RS08030	COG1757	Na H antiporter
CLAM6_RS08035	COG1115	amino acid carrier protein
CLAM6_RS08040	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CLAM6_RS08045	COG1192	Involved in chromosome partitioning
CLAM6_RS08055	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CLAM6_RS08070	COG2351	hydroxyisourate hydrolase activity
CLAM6_RS08090	COG1902	pentaerythritol trinitrate reductase activity
CLAM6_RS08090	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLAM6_RS08125	COG0252	asparaginase activity
CLAM6_RS08150	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CLAM6_RS08160	COG1522	sequence-specific DNA binding
CLAM6_RS08165	COG0737	Belongs to the 5'-nucleotidase family
CLAM6_RS08170	COG2233	PERMEase
CLAM6_RS08185	COG0402	S-adenosylhomocysteine deaminase activity
CLAM6_RS08190	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CLAM6_RS08190	COG3608	succinylglutamate desuccinylase aspartoacylase
CLAM6_RS08195	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CLAM6_RS08200	COG2080	2 iron, 2 sulfur cluster binding
CLAM6_RS08205	COG1309	transcriptional regulator
CLAM6_RS08230	COG0765	amino acid transport
CLAM6_RS08235	COG0765	amino acid transport
CLAM6_RS08240	COG1126	abc transporter atp-binding protein
CLAM6_RS08245	COG0154	amidase activity
CLAM6_RS08275	COG0709	Synthesizes selenophosphate from selenide and ATP
CLAM6_RS08285	COG3338	carbonate dehydratase activity
CLAM6_RS08290	COG0303	'Molybdopterin
CLAM6_RS08295	COG0521	Mo-molybdopterin cofactor biosynthetic process
CLAM6_RS08310	COG0437	4 iron, 4 sulfur cluster binding
CLAM6_RS08315	COG3383	formate dehydrogenase (NAD+) activity
CLAM6_RS08315	COG0243	molybdopterin cofactor binding
CLAM6_RS08345	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CLAM6_RS08375	COG4175	Glycine betaine
CLAM6_RS08375	COG0517	IMP dehydrogenase activity
CLAM6_RS08390	COG0564	pseudouridine synthase activity
CLAM6_RS08400	COG0259	pyridoxamine-phosphate oxidase activity
CLAM6_RS08405	COG1687	branched-chain amino acid
CLAM6_RS08410	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CLAM6_RS08435	COG1393	Belongs to the ArsC family
CLAM6_RS08440	COG1295	ribonuclease BN
CLAM6_RS08445	COG3842	ATPase activity
CLAM6_RS08450	COG1176	ABC-type spermidine putrescine transport system, permease component I
CLAM6_RS08455	COG1177	transmembrane transport
CLAM6_RS08465	COG2840	Smr protein MutS2
CLAM6_RS08475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLAM6_RS08480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLAM6_RS08490	COG1301	dicarboxylic acid transport
CLAM6_RS08495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CLAM6_RS08500	COG0022	dehydrogenase e1 component
CLAM6_RS08510	COG0515	serine threonine protein kinase
CLAM6_RS08520	COG1027	Aspartate ammonia-lyase
CLAM6_RS08525	COG0583	DNA-binding transcription factor activity
CLAM6_RS08530	COG1051	belongs to the nudix hydrolase family
CLAM6_RS08530	COG1056	cytidyltransferase-related domain
CLAM6_RS08540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLAM6_RS08550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLAM6_RS08560	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CLAM6_RS08565	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CLAM6_RS08570	COG0632	four-way junction helicase activity
CLAM6_RS08575	COG2255	four-way junction helicase activity
CLAM6_RS08580	COG0824	Thioesterase
CLAM6_RS08600	COG0823	Involved in the tonB-independent uptake of proteins
CLAM6_RS08615	COG1028	Short-chain dehydrogenase reductase Sdr
CLAM6_RS08635	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CLAM6_RS08660	COG0729	surface antigen
CLAM6_RS08665	COG2911	Protein conserved in bacteria
CLAM6_RS08670	COG3012	SEC-C Motif Domain Protein
CLAM6_RS08675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLAM6_RS08685	COG0429	hydrolase of the alpha beta-hydrolase fold
CLAM6_RS08690	COG0006	proline dipeptidase activity
CLAM6_RS08695	COG0583	DNA-binding transcription factor activity
CLAM6_RS08700	COG4608	Belongs to the ABC transporter superfamily
CLAM6_RS08705	COG0444	Belongs to the ABC transporter superfamily
CLAM6_RS08710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLAM6_RS08715	COG0601	transmembrane transport
CLAM6_RS08720	COG0747	negative chemotaxis
CLAM6_RS08725	COG0288	reversible hydration of carbon dioxide
CLAM6_RS08745	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CLAM6_RS08760	COG2166	iron-sulfur cluster assembly
CLAM6_RS08770	COG5642	Protein of unknown function (DUF2384)
CLAM6_RS08775	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CLAM6_RS08780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CLAM6_RS08785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CLAM6_RS08790	COG1121	(ABC) transporter
CLAM6_RS08800	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CLAM6_RS08805	COG0735	belongs to the Fur family
CLAM6_RS08825	COG0189	ligase activity
CLAM6_RS08825	COG4067	protein conserved in archaea
CLAM6_RS08855	COG4974	Belongs to the 'phage' integrase family
CLAM6_RS08870	COG1917	Cupin 2, conserved barrel domain protein
CLAM6_RS08875	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CLAM6_RS08880	COG0456	acetyltransferase
CLAM6_RS08890	COG0316	Belongs to the HesB IscA family
CLAM6_RS08890	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CLAM6_RS08900	COG0534	Mate efflux family protein
CLAM6_RS08920	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLAM6_RS08960	COG2186	Transcriptional regulator
CLAM6_RS08965	COG4948	Mandelate Racemase Muconate Lactonizing
CLAM6_RS08970	COG1028	Short-chain dehydrogenase reductase Sdr
CLAM6_RS08975	COG3734	2-keto-3-deoxy-galactonokinase
CLAM6_RS08980	COG0800	Aldolase
CLAM6_RS08985	COG3386	PFAM SMP-30 Gluconolaconase
CLAM6_RS09000	COG2610	gluconate transmembrane transporter activity
CLAM6_RS09010	COG1289	transmembrane transporter activity
CLAM6_RS09015	COG1566	PFAM secretion protein HlyD family protein
CLAM6_RS09035	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLAM6_RS09045	COG1191	sigma factor activity
CLAM6_RS09065	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLAM6_RS09090	COG1580	Controls the rotational direction of flagella during chemotaxis
CLAM6_RS09095	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLAM6_RS09115	COG1987	bacterial-type flagellum assembly
CLAM6_RS09125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLAM6_RS09130	COG1256	bacterial-type flagellum assembly
CLAM6_RS09135	COG1705	Flagellar rod assembly protein muramidase FlgJ
CLAM6_RS09135	COG3951	Flagellar rod assembly protein muramidase FlgJ
CLAM6_RS09140	COG1706	bacterial-type flagellum-dependent cell motility
CLAM6_RS09155	COG4787	bacterial-type flagellum-dependent cell motility
CLAM6_RS09160	COG1749	Flagellar hook protein flgE
CLAM6_RS09165	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CLAM6_RS09200	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLAM6_RS09205	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLAM6_RS09215	COG0745	RESPONSE REGULATOR receiver
CLAM6_RS09225	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLAM6_RS09230	COG0840	transmembrane signaling receptor activity
CLAM6_RS09235	COG0835	chemotaxis
CLAM6_RS09240	COG2198	Histidine kinase
CLAM6_RS09240	COG0643	Histidine kinase
CLAM6_RS09245	COG1360	Flagellar Motor Protein
CLAM6_RS09280	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CLAM6_RS09285	COG1869	D-ribose catabolic process
CLAM6_RS09290	COG1129	ABC transporter
CLAM6_RS09295	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLAM6_RS09300	COG1879	ABC-type sugar transport system periplasmic component
CLAM6_RS09305	COG1609	Transcriptional regulator
CLAM6_RS09310	COG2814	Major facilitator Superfamily
CLAM6_RS09330	COG2010	Cytochrome c
CLAM6_RS09350	COG0662	Cupin 2, conserved barrel domain protein
CLAM6_RS09350	COG2207	Transcriptional regulator
CLAM6_RS09355	COG0697	spore germination
CLAM6_RS09365	COG3093	addiction module antidote protein HigA
CLAM6_RS09370	COG3549	Plasmid maintenance system killer
CLAM6_RS09375	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CLAM6_RS09380	COG0243	molybdopterin cofactor binding
CLAM6_RS09400	COG1028	Short-chain dehydrogenase reductase Sdr
CLAM6_RS09430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLAM6_RS09435	COG1012	belongs to the aldehyde dehydrogenase family
CLAM6_RS09440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CLAM6_RS09450	COG2040	homocysteine
CLAM6_RS09460	COG1957	nucleoside hydrolase
CLAM6_RS09490	COG2267	carboxylic ester hydrolase activity
CLAM6_RS09495	COG2873	o-acetylhomoserine
CLAM6_RS09500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLAM6_RS09510	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLAM6_RS09510	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CLAM6_RS09530	COG1012	belongs to the aldehyde dehydrogenase family
CLAM6_RS09535	COG0583	DNA-binding transcription factor activity
CLAM6_RS09545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLAM6_RS09555	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLAM6_RS09575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLAM6_RS09590	COG3314	Sporulation integral membrane protein YlbJ
CLAM6_RS09600	COG1012	belongs to the aldehyde dehydrogenase family
CLAM6_RS09610	COG1252	NADH dehydrogenase
CLAM6_RS09625	COG2814	Major facilitator Superfamily
CLAM6_RS09660	COG2942	2-epimerase
CLAM6_RS09670	COG1473	amidohydrolase
CLAM6_RS09685	COG0583	DNA-binding transcription factor activity
CLAM6_RS09725	COG3706	GGDEF domain
CLAM6_RS09740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLAM6_RS09750	COG3023	N-Acetylmuramoyl-L-alanine amidase
CLAM6_RS09785	COG0556	nucleotide-excision repair
CLAM6_RS09810	COG0084	hydrolase, TatD family'
CLAM6_RS09815	COG1970	mechanosensitive ion channel activity
CLAM6_RS09820	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CLAM6_RS09825	COG0789	Transcriptional regulator
CLAM6_RS09835	COG0625	glutathione transferase activity
CLAM6_RS09845	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CLAM6_RS09860	COG0415	Belongs to the DNA photolyase family
CLAM6_RS09865	COG5000	phosphorelay sensor kinase activity
CLAM6_RS09870	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CLAM6_RS09875	COG1028	Short-chain dehydrogenase reductase Sdr
CLAM6_RS09895	COG1346	cytolysis
CLAM6_RS09905	COG5002	protein histidine kinase activity
CLAM6_RS09905	COG5001	Diguanylate cyclase
CLAM6_RS09920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CLAM6_RS09925	COG1012	belongs to the aldehyde dehydrogenase family
CLAM6_RS09930	COG1230	cation diffusion facilitator family transporter
CLAM6_RS09950	COG4807	Protein conserved in bacteria
CLAM6_RS09955	COG0640	Transcriptional regulator
CLAM6_RS09965	COG1064	alcohol dehydrogenase
CLAM6_RS09980	COG0477	Major facilitator Superfamily
CLAM6_RS09990	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CLAM6_RS10010	COG3842	ATPase activity
CLAM6_RS10035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CLAM6_RS10040	COG0640	Transcriptional regulator
CLAM6_RS10045	COG3118	belongs to the thioredoxin family
CLAM6_RS10060	COG0583	DNA-binding transcription factor activity
CLAM6_RS10075	COG2203	Gaf domain
CLAM6_RS10075	COG4251	negative regulation of phosphorylation
CLAM6_RS10075	COG3706	GGDEF domain
CLAM6_RS10075	COG5001	Diguanylate cyclase
CLAM6_RS10090	COG2814	Major facilitator Superfamily
CLAM6_RS10105	COG0656	L-ascorbic acid biosynthetic process
CLAM6_RS10110	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CLAM6_RS10115	COG4988	ABC transporter
CLAM6_RS10120	COG1294	oxidase, subunit
CLAM6_RS10125	COG1271	oxidase subunit
CLAM6_RS10135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CLAM6_RS10140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CLAM6_RS10155	COG0356	it plays a direct role in the translocation of protons across the membrane
CLAM6_RS10165	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CLAM6_RS10165	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLAM6_RS10170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CLAM6_RS10180	COG3243	poly(R)-hydroxyalkanoic acid synthase
CLAM6_RS10185	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CLAM6_RS10195	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CLAM6_RS10200	COG3300	MHYT domain
CLAM6_RS10200	COG5001	Diguanylate cyclase
CLAM6_RS10205	COG3706	GGDEF domain
CLAM6_RS10210	COG2610	gluconate transmembrane transporter activity
CLAM6_RS10215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLAM6_RS10220	COG3622	Belongs to the hyi family
CLAM6_RS10225	COG0235	Class ii aldolase
CLAM6_RS10230	COG3395	kinase activity
CLAM6_RS10235	COG2084	Dehydrogenase
CLAM6_RS10240	COG1609	Transcriptional regulator
CLAM6_RS10245	COG3246	L-lysine catabolic process to acetate
CLAM6_RS10255	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLAM6_RS10255	COG0824	Thioesterase
CLAM6_RS10300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLAM6_RS10310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLAM6_RS10315	COG0156	8-amino-7-oxononanoate synthase activity
CLAM6_RS10320	COG1063	alcohol dehydrogenase
CLAM6_RS10325	COG0583	DNA-binding transcription factor activity
CLAM6_RS10335	COG1741	Belongs to the pirin family
CLAM6_RS10350	COG0697	spore germination
CLAM6_RS10355	COG1620	l-lactate permease
CLAM6_RS10375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CLAM6_RS10375	COG1017	nitric oxide dioxygenase activity
CLAM6_RS10390	COG0583	DNA-binding transcription factor activity
CLAM6_RS10395	COG0583	DNA-binding transcription factor activity
CLAM6_RS10405	COG1012	belongs to the aldehyde dehydrogenase family
CLAM6_RS10410	COG2936	dipeptidyl-peptidase activity
CLAM6_RS10415	COG0583	DNA-binding transcription factor activity
CLAM6_RS10420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLAM6_RS10425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLAM6_RS10435	COG0659	secondary active sulfate transmembrane transporter activity
CLAM6_RS10440	COG2186	Transcriptional regulator
CLAM6_RS10470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLAM6_RS10495	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLAM6_RS10505	COG1312	Catalyzes the dehydration of D-mannonate
CLAM6_RS10510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CLAM6_RS10545	COG2375	cellular response to nickel ion
CLAM6_RS10555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLAM6_RS10580	COG0666	response to abiotic stimulus
CLAM6_RS10585	COG0753	catalase activity
CLAM6_RS10590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLAM6_RS10595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CLAM6_RS10605	COG1942	4-Oxalocrotonate Tautomerase
CLAM6_RS10630	COG0583	DNA-binding transcription factor activity
CLAM6_RS10655	COG3938	Belongs to the proline racemase family
CLAM6_RS10660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLAM6_RS10685	COG2433	Pfam Transposase IS66
CLAM6_RS10705	COG1757	Na H antiporter
CLAM6_RS10720	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CLAM6_RS10725	COG1088	dTDP-glucose 4,6-dehydratase activity
CLAM6_RS10740	COG0438	transferase activity, transferring glycosyl groups
CLAM6_RS10740	COG1216	Glycosyl transferase, family 2
CLAM6_RS10750	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CLAM6_RS10765	COG1216	Glycosyl transferase, family 2
CLAM6_RS10785	COG0438	transferase activity, transferring glycosyl groups
CLAM6_RS10790	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CLAM6_RS10795	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CLAM6_RS10840	COG0175	sulfate reduction
CLAM6_RS10850	COG0471	metal ion transport
CLAM6_RS10850	COG3273	potassium ion transport
CLAM6_RS10875	COG0604	alcohol dehydrogenase
CLAM6_RS10875	COG3321	synthase
CLAM6_RS10875	COG1028	Short-chain dehydrogenase reductase Sdr
CLAM6_RS10880	COG0156	8-amino-7-oxononanoate synthase activity
CLAM6_RS10915	COG3307	-O-antigen
CLAM6_RS10925	COG1216	Glycosyl transferase, family 2
CLAM6_RS10935	COG1051	belongs to the nudix hydrolase family
CLAM6_RS10945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLAM6_RS10980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLAM6_RS11015	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLAM6_RS11020	COG0028	Belongs to the TPP enzyme family
CLAM6_RS11025	COG2070	2-Nitropropane dioxygenase
CLAM6_RS11060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLAM6_RS11065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLAM6_RS11075	COG1396	sequence-specific DNA binding
CLAM6_RS11080	COG2186	Transcriptional regulator
CLAM6_RS11090	COG4948	Mandelate Racemase Muconate Lactonizing
CLAM6_RS11100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLAM6_RS11110	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLAM6_RS11115	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CLAM6_RS11120	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLAM6_RS11125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLAM6_RS11150	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLAM6_RS11185	COG0583	DNA-binding transcription factor activity
CLAM6_RS11195	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLAM6_RS11195	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CLAM6_RS11205	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLAM6_RS11225	COG1121	(ABC) transporter
CLAM6_RS11230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CLAM6_RS11250	COG0830	nickel cation binding
CLAM6_RS11255	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CLAM6_RS11260	COG0804	urea catabolic process
CLAM6_RS11265	COG0832	Belongs to the urease beta subunit family
CLAM6_RS11270	COG0831	urea catabolic process
CLAM6_RS11275	COG0829	nickel cation binding
CLAM6_RS11305	COG4974	Belongs to the 'phage' integrase family
CLAM6_RS11330	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CLAM6_RS11335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLAM6_RS11340	COG1271	oxidase subunit
CLAM6_RS11345	COG1294	oxidase, subunit
CLAM6_RS11355	COG0251	oxidation-reduction process
CLAM6_RS11370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLAM6_RS11380	COG1012	belongs to the aldehyde dehydrogenase family
CLAM6_RS11385	COG0583	DNA-binding transcription factor activity
CLAM6_RS11400	COG5642	Protein of unknown function (DUF2384)
CLAM6_RS11420	COG1192	Involved in chromosome partitioning
CLAM6_RS11450	COG2175	clavaminate synthase activity
CLAM6_RS11465	COG3791	Glutathione-dependent formaldehyde-activating
CLAM6_RS11470	COG0583	DNA-binding transcription factor activity
CLAM6_RS11540	COG1120	ATPase activity
CLAM6_RS11545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLAM6_RS11555	COG3568	Endonuclease Exonuclease Phosphatase
CLAM6_RS11555	COG1555	photosystem II stabilization
CLAM6_RS11565	COG0352	thiamine-phosphate diphosphorylase activity
CLAM6_RS11570	COG0531	amino acid
CLAM6_RS11575	COG4302	ethanolamine ammonia-lyase activity
CLAM6_RS11580	COG4303	Ethanolamine ammonia lyase large subunit
CLAM6_RS11590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CLAM6_RS11605	COG0438	transferase activity, transferring glycosyl groups
CLAM6_RS11640	COG2244	polysaccharide biosynthetic process
CLAM6_RS11655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLAM6_RS11660	COG0489	protein tyrosine kinase activity
CLAM6_RS11660	COG3206	protein involved in exopolysaccharide biosynthesis
CLAM6_RS11665	COG1596	polysaccharide export
CLAM6_RS11675	COG0438	transferase activity, transferring glycosyl groups
CLAM6_RS11690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CLAM6_RS11705	COG1215	transferase activity, transferring glycosyl groups
CLAM6_RS11710	COG0438	transferase activity, transferring glycosyl groups
CLAM6_RS11730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLAM6_RS11760	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLAM6_RS11770	COG0427	acetyl-CoA hydrolase
CLAM6_RS11785	COG1611	Belongs to the LOG family
CLAM6_RS11805	COG0583	DNA-binding transcription factor activity
CLAM6_RS11815	COG0432	Pfam Uncharacterised protein family UPF0047
CLAM6_RS11835	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLAM6_RS11840	COG0628	permease
CLAM6_RS11845	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CLAM6_RS11850	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CLAM6_RS11855	COG4625	pathogenesis
CLAM6_RS11855	COG3240	lipase activity
CLAM6_RS11860	COG0717	Belongs to the dCTP deaminase family
CLAM6_RS11865	COG0489	protein tyrosine kinase activity
CLAM6_RS11880	COG1785	Belongs to the alkaline phosphatase family
CLAM6_RS11890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLAM6_RS11890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLAM6_RS11905	COG4657	Part of a membrane complex involved in electron transport
CLAM6_RS11910	COG2878	Part of a membrane complex involved in electron transport
CLAM6_RS11915	COG4656	Part of a membrane complex involved in electron transport
CLAM6_RS11920	COG4658	electron transport chain
CLAM6_RS11925	COG4659	FMN binding
CLAM6_RS11930	COG4660	Part of a membrane complex involved in electron transport
CLAM6_RS11935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CLAM6_RS11950	COG0308	aminopeptidase N
CLAM6_RS11960	COG1929	Belongs to the glycerate kinase type-1 family
CLAM6_RS11965	COG2996	Protein conserved in bacteria
CLAM6_RS11970	COG1666	GTP binding
CLAM6_RS11980	COG0189	ligase activity
CLAM6_RS12005	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CLAM6_RS12040	COG2056	Na+-H+ antiporter family
CLAM6_RS12045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLAM6_RS12050	COG0788	formyltetrahydrofolate deformylase activity
CLAM6_RS12065	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CLAM6_RS12070	COG0314	molybdopterin synthase activity
CLAM6_RS12075	COG0315	cyclic pyranopterin monophosphate synthase activity
CLAM6_RS12080	COG0303	'Molybdopterin
CLAM6_RS12085	COG1763	Mo-molybdopterin cofactor biosynthetic process
CLAM6_RS12090	COG0746	molybdenum cofactor guanylyltransferase activity
CLAM6_RS12100	COG4662	Binding-protein-dependent transport system inner membrane component
CLAM6_RS12110	COG2204	response regulator
CLAM6_RS12115	COG3852	Histidine kinase
CLAM6_RS12120	COG1917	Cupin 2, conserved barrel domain protein
CLAM6_RS12120	COG1396	sequence-specific DNA binding
CLAM6_RS12125	COG0438	transferase activity, transferring glycosyl groups
CLAM6_RS12135	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CLAM6_RS12145	COG1442	glycosyl transferase family 8
CLAM6_RS12160	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CLAM6_RS12165	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CLAM6_RS12170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLAM6_RS12175	COG2252	PERMEase
CLAM6_RS12180	COG0307	riboflavin synthase, alpha
CLAM6_RS12185	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLAM6_RS12190	COG2011	ABC-type metal ion transport system permease component
CLAM6_RS12195	COG1464	Belongs to the NlpA lipoprotein family
CLAM6_RS12200	COG1956	GAF domain-containing protein
CLAM6_RS12225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CLAM6_RS12230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CLAM6_RS12235	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CLAM6_RS12240	COG1349	DNA-binding transcription factor activity
CLAM6_RS12255	COG1289	transmembrane transporter activity
CLAM6_RS12260	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CLAM6_RS12270	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CLAM6_RS12275	COG0776	regulation of translation
CLAM6_RS12285	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CLAM6_RS12290	COG0733	neurotransmitter:sodium symporter activity
CLAM6_RS12295	COG0569	domain protein
CLAM6_RS12300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CLAM6_RS12305	COG0776	regulation of translation
CLAM6_RS12310	COG0072	phenylalanine-tRNA ligase activity
CLAM6_RS12315	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CLAM6_RS12320	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CLAM6_RS12325	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CLAM6_RS12335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLAM6_RS12345	COG1473	amidohydrolase
CLAM6_RS12355	COG0297	glycogen (starch) synthase activity
CLAM6_RS12365	COG2194	sulfuric ester hydrolase activity
CLAM6_RS12370	COG1218	3'(2'),5'-bisphosphate nucleotidase
CLAM6_RS12375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CLAM6_RS12380	COG0471	metal ion transport
CLAM6_RS12385	COG0786	glutamate:sodium symporter activity
CLAM6_RS12390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLAM6_RS12415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLAM6_RS12420	COG1063	alcohol dehydrogenase
CLAM6_RS12430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CLAM6_RS12450	COG2154	pterin-4-alpha-carbinolamine dehydratase
CLAM6_RS12460	COG0583	DNA-binding transcription factor activity
CLAM6_RS12470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLAM6_RS12475	COG0534	Mate efflux family protein
CLAM6_RS12480	COG0583	DNA-binding transcription factor activity
CLAM6_RS12485	COG4251	negative regulation of phosphorylation
CLAM6_RS12485	COG2203	Gaf domain
CLAM6_RS12485	COG3706	GGDEF domain
CLAM6_RS12485	COG5001	Diguanylate cyclase
CLAM6_RS12490	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CLAM6_RS12495	COG0602	queuosine metabolic process
CLAM6_RS12510	COG0523	cobalamin synthesis protein
CLAM6_RS12515	COG1979	alcohol dehydrogenase
CLAM6_RS12520	COG2130	NADP-dependent
CLAM6_RS12525	COG0583	DNA-binding transcription factor activity
CLAM6_RS12530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLAM6_RS12540	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CLAM6_RS12545	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CLAM6_RS12550	COG0740	serine-type endopeptidase activity
CLAM6_RS12555	COG0544	peptidyl-prolyl cis-trans isomerase activity
CLAM6_RS12580	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CLAM6_RS12585	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CLAM6_RS12590	COG0215	cysteine-tRNA ligase activity
CLAM6_RS12595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLAM6_RS12600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CLAM6_RS12605	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLAM6_RS12635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CLAM6_RS12640	COG1301	dicarboxylic acid transport
CLAM6_RS12650	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CLAM6_RS12655	COG3123	guanosine phosphorylase activity
CLAM6_RS12660	COG0534	Mate efflux family protein
CLAM6_RS12675	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLAM6_RS12675	COG1024	Enoyl-CoA hydratase
CLAM6_RS12680	COG1024	Enoyl-CoA hydratase
CLAM6_RS12685	COG1960	acyl-CoA dehydrogenase activity
CLAM6_RS12700	COG0318	PFAM AMP-dependent synthetase and ligase
CLAM6_RS12710	COG1984	allophanate hydrolase subunit 2
CLAM6_RS12715	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CLAM6_RS12720	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CLAM6_RS12750	COG1174	glycine betaine transport
CLAM6_RS12755	COG0517	IMP dehydrogenase activity
CLAM6_RS12755	COG1125	glycine betaine transport
CLAM6_RS12760	COG1960	acyl-CoA dehydrogenase activity
CLAM6_RS12765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CLAM6_RS12785	COG2824	Alkylphosphonate utilization operon protein PhnA
CLAM6_RS12805	COG2855	membrane
CLAM6_RS12830	COG1414	Transcriptional regulator
CLAM6_RS12840	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CLAM6_RS12840	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLAM6_RS12845	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLAM6_RS12845	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CLAM6_RS12850	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLAM6_RS12855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLAM6_RS12860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLAM6_RS12885	COG0653	protein targeting
CLAM6_RS12910	COG1414	Transcriptional regulator
CLAM6_RS12915	COG0697	spore germination
CLAM6_RS12925	COG5001	Diguanylate cyclase
CLAM6_RS12925	COG5002	protein histidine kinase activity
CLAM6_RS12925	COG3447	MASE1 domain protein
CLAM6_RS12940	COG0137	argininosuccinate synthase activity
CLAM6_RS12945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CLAM6_RS12950	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CLAM6_RS12955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLAM6_RS12960	COG3842	ATPase activity
CLAM6_RS12965	COG2207	Transcriptional regulator
CLAM6_RS12965	COG3708	Transcriptional regulator
CLAM6_RS12990	COG0322	excinuclease ABC activity
CLAM6_RS13025	COG5290	Psort location Cytoplasmic, score
CLAM6_RS13040	COG2826	transposase and inactivated derivatives, IS30 family
CLAM6_RS13135	COG0442	prolyl-tRNA aminoacylation
CLAM6_RS13145	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CLAM6_RS13150	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CLAM6_RS13155	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CLAM6_RS13160	COG1011	Hydrolase
CLAM6_RS13165	COG0494	nUDIX hydrolase
CLAM6_RS13175	COG0433	COG0433 Predicted ATPase
CLAM6_RS13185	COG0129	dihydroxy-acid dehydratase activity
CLAM6_RS13195	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CLAM6_RS13205	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CLAM6_RS13215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLAM6_RS13220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CLAM6_RS13230	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLAM6_RS13230	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLAM6_RS13235	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CLAM6_RS13250	COG1215	transferase activity, transferring glycosyl groups
CLAM6_RS13260	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CLAM6_RS13270	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CLAM6_RS13285	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLAM6_RS13290	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CLAM6_RS13295	COG4181	ATPase activity
CLAM6_RS13305	COG2326	polyphosphate kinase activity
CLAM6_RS13330	COG1366	Belongs to the anti-sigma-factor antagonist family
CLAM6_RS13340	COG0488	(ABC) transporter
CLAM6_RS13360	COG1560	Kdo2-lipid A biosynthetic process
CLAM6_RS13365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CLAM6_RS13370	COG1538	Outer membrane efflux protein
CLAM6_RS13380	COG4942	peptidase
CLAM6_RS13380	COG1388	LysM domain
CLAM6_RS13390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CLAM6_RS13395	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CLAM6_RS13400	COG0585	pseudouridine synthase activity
CLAM6_RS13405	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CLAM6_RS13410	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CLAM6_RS13415	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CLAM6_RS13470	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CLAM6_RS13480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLAM6_RS13510	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CLAM6_RS13520	COG5002	protein histidine kinase activity
CLAM6_RS13520	COG5001	Diguanylate cyclase
CLAM6_RS13520	COG3447	MASE1 domain protein
CLAM6_RS13540	COG0837	glucose binding
CLAM6_RS13545	COG0676	glucose-6-phosphate 1-epimerase activity
CLAM6_RS13550	COG0166	Belongs to the GPI family
CLAM6_RS13570	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CLAM6_RS13575	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLAM6_RS13590	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CLAM6_RS13595	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CLAM6_RS13600	COG0730	response to heat
CLAM6_RS13605	COG0745	RESPONSE REGULATOR receiver
CLAM6_RS13625	COG0560	Phosphoserine phosphatase
CLAM6_RS13630	COG0579	oxidoreductase
CLAM6_RS13640	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CLAM6_RS13645	COG2918	glutathione biosynthetic process
CLAM6_RS13650	COG2183	response to ionizing radiation
CLAM6_RS13655	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLAM6_RS13660	COG1028	Short-chain dehydrogenase reductase Sdr
CLAM6_RS13670	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CLAM6_RS13675	COG0459	protein refolding
CLAM6_RS13695	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CLAM6_RS13700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CLAM6_RS13720	COG0824	Thioesterase
CLAM6_RS13730	COG2974	May be involved in recombination
CLAM6_RS13740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CLAM6_RS13755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLAM6_RS13760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLAM6_RS13785	COG2986	histidine ammonia-lyase
CLAM6_RS13815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLAM6_RS13825	COG1028	Short-chain dehydrogenase reductase Sdr
CLAM6_RS13830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLAM6_RS13835	COG0393	Putative heavy-metal-binding
CLAM6_RS13855	COG0589	response to stress
CLAM6_RS13860	COG0659	secondary active sulfate transmembrane transporter activity
CLAM6_RS13875	COG2423	ornithine cyclodeaminase activity
CLAM6_RS13880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CLAM6_RS13885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CLAM6_RS13890	COG1012	belongs to the aldehyde dehydrogenase family
CLAM6_RS13900	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CLAM6_RS13905	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CLAM6_RS13910	COG1674	ftsk spoiiie
CLAM6_RS13920	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CLAM6_RS13925	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CLAM6_RS13930	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CLAM6_RS13935	COG0542	response to heat
CLAM6_RS13960	COG0482	sulfurtransferase activity
CLAM6_RS13965	COG2915	High frequency lysogenization protein hflD homolog
CLAM6_RS13975	COG2850	peptidyl-arginine hydroxylation
CLAM6_RS13990	COG2224	Isocitrate lyase
CLAM6_RS14000	COG3133	Outer membrane lipoprotein
CLAM6_RS14025	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CLAM6_RS14030	COG4135	transport system, permease component
CLAM6_RS14035	COG4134	Bacterial extracellular solute-binding protein
CLAM6_RS14050	COG2814	Major facilitator Superfamily
CLAM6_RS14055	COG0583	DNA-binding transcription factor activity
CLAM6_RS14060	COG0791	NLP P60 protein
CLAM6_RS14085	COG2983	Belongs to the UPF0260 family
CLAM6_RS14090	COG3100	YcgL domain-containing protein
CLAM6_RS14100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CLAM6_RS14105	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CLAM6_RS14110	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CLAM6_RS14120	COG3180	Ammonia monooxygenase
CLAM6_RS14140	COG3264	Mechanosensitive ion channel
CLAM6_RS14140	COG1196	nuclear chromosome segregation
CLAM6_RS14150	COG4575	ribosome binding
CLAM6_RS14170	COG0583	DNA-binding transcription factor activity
CLAM6_RS14175	COG2081	HI0933 family
CLAM6_RS14180	COG0488	(ABC) transporter
CLAM6_RS14200	COG0778	Nitroreductase
CLAM6_RS14205	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CLAM6_RS14205	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CLAM6_RS14210	COG0842	Transport permease protein
CLAM6_RS14215	COG1131	(ABC) transporter
CLAM6_RS14260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLAM6_RS14265	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CLAM6_RS14270	COG0436	Aminotransferase
CLAM6_RS14275	COG0501	Belongs to the peptidase M48B family
CLAM6_RS14280	COG1309	transcriptional regulator
CLAM6_RS14295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLAM6_RS14300	COG4215	(ABC) transporter
CLAM6_RS14310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLAM6_RS14315	COG1757	Na H antiporter
CLAM6_RS14320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CLAM6_RS14335	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CLAM6_RS14335	COG0116	Belongs to the methyltransferase superfamily
CLAM6_RS14340	COG3130	regulation of translation
CLAM6_RS14345	COG0167	dihydroorotate dehydrogenase activity
CLAM6_RS14355	COG2902	Dehydrogenase
CLAM6_RS14360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CLAM6_RS14365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CLAM6_RS14375	COG1522	sequence-specific DNA binding
CLAM6_RS14380	COG3608	succinylglutamate desuccinylase aspartoacylase
CLAM6_RS14385	COG0006	proline dipeptidase activity
CLAM6_RS14395	COG1522	sequence-specific DNA binding
CLAM6_RS14405	COG0693	protein deglycase activity
CLAM6_RS14415	COG2431	L-lysine efflux transmembrane transporter activity
CLAM6_RS14420	COG1609	Transcriptional regulator
CLAM6_RS14425	COG3265	gluconokinase activity
CLAM6_RS14430	COG2610	gluconate transmembrane transporter activity
CLAM6_RS14435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLAM6_RS14440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLAM6_RS14445	COG2205	protein histidine kinase activity
CLAM6_RS14450	COG0745	RESPONSE REGULATOR receiver
CLAM6_RS14465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLAM6_RS14470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLAM6_RS14470	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CLAM6_RS14470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLAM6_RS14475	COG1105	Belongs to the carbohydrate kinase PfkB family
CLAM6_RS14485	COG1609	Transcriptional regulator
CLAM6_RS14505	COG0123	including yeast histone deacetylase and acetoin utilization protein
CLAM6_RS14510	COG3217	Mosc domain protein beta barrel domain protein
CLAM6_RS14510	COG0633	Ferredoxin
CLAM6_RS14520	COG4149	molybdate abc transporter
CLAM6_RS14525	COG0725	ABC transporter, periplasmic molybdate-binding protein
CLAM6_RS14530	COG0583	DNA-binding transcription factor activity
CLAM6_RS14535	COG0625	glutathione transferase activity
CLAM6_RS14545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLAM6_RS14545	COG3153	acetyltransferase
CLAM6_RS14550	COG3228	Belongs to the MtfA family
CLAM6_RS14570	COG3040	lipid binding
CLAM6_RS14580	COG2988	succinylglutamate desuccinylase activity
CLAM6_RS14590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLAM6_RS14600	COG4160	amino acid transport
CLAM6_RS14645	COG0519	Catalyzes the synthesis of GMP from XMP
CLAM6_RS14655	COG3724	N-succinylarginine dihydrolase activity
CLAM6_RS14660	COG1012	belongs to the aldehyde dehydrogenase family
CLAM6_RS14685	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CLAM6_RS14705	COG1538	Outer membrane efflux protein
CLAM6_RS14715	COG2274	protein secretion by the type I secretion system
CLAM6_RS14735	COG0714	Associated with various cellular activities
CLAM6_RS14765	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CLAM6_RS14770	COG0343	queuine tRNA-ribosyltransferase activity
CLAM6_RS14775	COG1862	Preprotein translocase
CLAM6_RS14810	COG1104	cysteine desulfurase activity
CLAM6_RS14820	COG0105	UTP biosynthetic process
CLAM6_RS14825	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CLAM6_RS14835	COG1426	Protein conserved in bacteria
CLAM6_RS14840	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CLAM6_RS14845	COG0124	histidyl-tRNA synthetase
CLAM6_RS14850	COG2976	Protein conserved in bacteria
CLAM6_RS14860	COG1160	GTP binding
CLAM6_RS14890	COG0745	RESPONSE REGULATOR receiver
CLAM6_RS14895	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLAM6_RS14900	COG0408	coproporphyrinogen oxidase activity
CLAM6_RS14905	COG0009	L-threonylcarbamoyladenylate synthase
CLAM6_RS14915	COG0758	DNA mediated transformation
CLAM6_RS14920	COG1652	LysM domain
CLAM6_RS14925	COG0242	peptide deformylase activity
CLAM6_RS14930	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CLAM6_RS14940	COG0569	domain protein
CLAM6_RS14945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CLAM6_RS14950	COG3148	PFAM DTW domain containing protein
CLAM6_RS14955	COG0385	Bile acid
CLAM6_RS14960	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CLAM6_RS14965	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CLAM6_RS14970	COG0037	tRNA processing
CLAM6_RS14990	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLAM6_RS15000	COG2205	protein histidine kinase activity
CLAM6_RS15000	COG0784	Response regulator, receiver
CLAM6_RS15000	COG2198	Histidine kinase
CLAM6_RS15010	COG0697	spore germination
CLAM6_RS15015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CLAM6_RS15020	COG3091	SprT-like family
CLAM6_RS15035	COG2937	Belongs to the GPAT DAPAT family
CLAM6_RS15040	COG0742	ribosomal rna small subunit methyltransferase
CLAM6_RS15045	COG1968	undecaprenyl-diphosphatase activity
CLAM6_RS15055	COG0563	adenylate kinase activity
CLAM6_RS15060	COG0861	Integral membrane protein TerC family
CLAM6_RS15090	COG1028	Short-chain dehydrogenase reductase Sdr
CLAM6_RS15105	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CLAM6_RS15110	COG0235	Class ii aldolase
CLAM6_RS15125	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CLAM6_RS15130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CLAM6_RS15140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLAM6_RS15145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CLAM6_RS15155	COG0425	Belongs to the sulfur carrier protein TusA family
CLAM6_RS15165	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CLAM6_RS15190	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CLAM6_RS15195	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CLAM6_RS15200	COG0180	Tryptophanyl-tRNA synthetase
CLAM6_RS15205	COG1061	Type III restriction enzyme res subunit
CLAM6_RS15215	COG0069	glutamate synthase activity
CLAM6_RS15225	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CLAM6_RS15240	COG1946	Acyl-CoA thioesterase
CLAM6_RS15265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CLAM6_RS15265	COG1648	precorrin-2 dehydrogenase activity
CLAM6_RS15270	COG0243	molybdopterin cofactor binding
CLAM6_RS15275	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLAM6_RS15280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLAM6_RS15280	COG2146	nitrite reductase [NAD(P)H] activity
CLAM6_RS15285	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLAM6_RS15285	COG2146	nitrite reductase [NAD(P)H] activity
CLAM6_RS15295	COG0559	Belongs to the binding-protein-dependent transport system permease family
CLAM6_RS15315	COG1760	l-serine dehydratase
CLAM6_RS15320	COG0583	DNA-binding transcription factor activity
CLAM6_RS15340	COG0358	DNA primase activity
CLAM6_RS15345	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CLAM6_RS15350	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CLAM6_RS15355	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CLAM6_RS15360	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CLAM6_RS15365	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CLAM6_RS15370	COG0617	tRNA 3'-terminal CCA addition
CLAM6_RS15375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CLAM6_RS15380	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CLAM6_RS15385	COG2967	ApaG domain
CLAM6_RS15390	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CLAM6_RS15395	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CLAM6_RS15400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLAM6_RS15405	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CLAM6_RS15410	COG3178	'Phosphotransferase
CLAM6_RS15415	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CLAM6_RS15420	COG1765	OsmC-like protein
CLAM6_RS15425	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CLAM6_RS15430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CLAM6_RS15445	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CLAM6_RS15450	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CLAM6_RS15455	COG0604	alcohol dehydrogenase
CLAM6_RS15480	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CLAM6_RS15490	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CLAM6_RS15495	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLAM6_RS15500	COG3706	GGDEF domain
CLAM6_RS15510	COG0534	Mate efflux family protein
CLAM6_RS15515	COG2031	fatty acid transporter
CLAM6_RS15520	COG1607	acyl-coa hydrolase
CLAM6_RS15525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CLAM6_RS15525	COG2169	Transcriptional regulator
CLAM6_RS15530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLAM6_RS15540	COG0625	glutathione transferase activity
CLAM6_RS15555	COG2818	Glycosylase
CLAM6_RS15565	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CLAM6_RS15570	COG0511	ligase activity, forming carbon-carbon bonds
CLAM6_RS15570	COG5016	pyruvate
CLAM6_RS15600	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CLAM6_RS15605	COG0527	aspartate kinase activity
CLAM6_RS15610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLAM6_RS15615	COG2137	regulation of response to DNA damage stimulus
CLAM6_RS15620	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CLAM6_RS15625	COG1546	Belongs to the CinA family
CLAM6_RS15630	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLAM6_RS15635	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CLAM6_RS15640	COG0148	phosphopyruvate hydratase activity
CLAM6_RS15645	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CLAM6_RS15650	COG0504	CTP synthase activity
CLAM6_RS15655	COG0493	'glutamate synthase
CLAM6_RS15660	COG0069	glutamate synthase activity
CLAM6_RS15660	COG0070	glutamate synthase
CLAM6_RS15660	COG0067	glutamate synthase
CLAM6_RS15665	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CLAM6_RS15670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CLAM6_RS15710	COG0281	malic enzyme
CLAM6_RS15715	COG0254	rRNA binding
CLAM6_RS15720	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CLAM6_RS15725	COG0018	arginyl-trna synthetase
CLAM6_RS15735	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CLAM6_RS15740	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CLAM6_RS15750	COG2226	methyltransferase
CLAM6_RS15760	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CLAM6_RS15765	COG0140	phosphoribosyl-ATP diphosphatase activity
CLAM6_RS15770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CLAM6_RS15775	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CLAM6_RS15785	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CLAM6_RS15820	COG1028	Short-chain dehydrogenase reductase Sdr
CLAM6_RS15830	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CLAM6_RS15855	COG0037	tRNA processing
CLAM6_RS15860	COG0825	malonyl-CoA metabolic process
CLAM6_RS15870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CLAM6_RS15875	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLAM6_RS15880	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLAM6_RS15885	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLAM6_RS15890	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLAM6_RS15900	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLAM6_RS15910	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CLAM6_RS15925	COG0233	cytoplasmic translational termination
CLAM6_RS15930	COG0528	UMP kinase activity
CLAM6_RS15935	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CLAM6_RS15940	COG0052	Belongs to the universal ribosomal protein uS2 family
CLAM6_RS15950	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CLAM6_RS15955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLAM6_RS15960	COG1393	Belongs to the ArsC family
CLAM6_RS15965	COG2171	N-acyltransferase activity
CLAM6_RS15970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLAM6_RS15990	COG0492	ferredoxin-NADP+ reductase activity
CLAM6_RS15995	COG0450	alkyl hydroperoxide reductase
CLAM6_RS16015	COG2391	methyltransferase activity
CLAM6_RS16020	COG0180	Tryptophanyl-tRNA synthetase
CLAM6_RS16025	COG0686	Belongs to the AlaDH PNT family
CLAM6_RS16045	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CLAM6_RS16050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CLAM6_RS16055	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CLAM6_RS16060	COG2003	Belongs to the UPF0758 family
CLAM6_RS16070	COG0756	dUTP diphosphatase activity
CLAM6_RS16080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CLAM6_RS16085	COG1309	transcriptional regulator
CLAM6_RS16090	COG5001	Diguanylate cyclase
CLAM6_RS16090	COG3300	MHYT domain
CLAM6_RS16100	COG2177	Part of the ABC transporter FtsEX involved in
CLAM6_RS16105	COG2884	Cell division ATP-binding protein ftsE
CLAM6_RS16110	COG0552	protein localization to endoplasmic reticulum
CLAM6_RS16115	COG0742	ribosomal rna small subunit methyltransferase
CLAM6_RS16125	COG0456	acetyltransferase
CLAM6_RS16135	COG0271	Belongs to the BolA IbaG family
CLAM6_RS16145	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CLAM6_RS16155	COG4166	transmembrane transport
CLAM6_RS16160	COG4166	transmembrane transport
CLAM6_RS16165	COG0601	transmembrane transport
CLAM6_RS16170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLAM6_RS16175	COG4172	Belongs to the ABC transporter superfamily
CLAM6_RS16190	COG0789	Transcriptional regulator
CLAM6_RS16195	COG2217	Heavy metal translocating P-type atpase
CLAM6_RS16225	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLAM6_RS16240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CLAM6_RS16250	COG0335	large ribosomal subunit rRNA binding
CLAM6_RS16255	COG0336	Belongs to the RNA methyltransferase TrmD family
CLAM6_RS16260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CLAM6_RS16265	COG0228	four-way junction DNA binding
CLAM6_RS16270	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CLAM6_RS16275	COG4137	Cytochrome C assembly protein
CLAM6_RS16280	COG4536	flavin adenine dinucleotide binding
CLAM6_RS16285	COG2814	Major facilitator Superfamily
CLAM6_RS16310	COG2925	Exonuclease
CLAM6_RS16315	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CLAM6_RS16320	COG2894	cell division
CLAM6_RS16325	COG0850	regulation of cytokinetic process
CLAM6_RS16335	COG1028	Short-chain dehydrogenase reductase Sdr
CLAM6_RS16360	COG3118	belongs to the thioredoxin family
CLAM6_RS16365	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CLAM6_RS16375	COG0589	response to stress
CLAM6_RS16380	COG1115	amino acid carrier protein
CLAM6_RS16415	COG0733	neurotransmitter:sodium symporter activity
CLAM6_RS16445	COG0667	Aldo Keto reductase
CLAM6_RS16450	COG3238	Protein conserved in bacteria
CLAM6_RS16455	COG3022	response to hydroperoxide
CLAM6_RS16485	COG1183	phosphatidylcholine synthase activity
CLAM6_RS16490	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CLAM6_RS16500	COG0440	acetolactate synthase activity
CLAM6_RS16505	COG0028	Belongs to the TPP enzyme family
CLAM6_RS16530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLAM6_RS16530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLAM6_RS16540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLAM6_RS16570	COG4969	Belongs to the N-Me-Phe pilin family
CLAM6_RS16575	COG4969	Belongs to the N-Me-Phe pilin family
CLAM6_RS16615	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLAM6_RS16620	COG1047	Peptidyl-prolyl cis-trans
CLAM6_RS16625	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CLAM6_RS16630	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CLAM6_RS16635	COG0196	riboflavin kinase activity
CLAM6_RS16640	COG0728	peptidoglycan biosynthetic process
CLAM6_RS16645	COG0268	Binds directly to 16S ribosomal RNA
CLAM6_RS16650	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CLAM6_RS16655	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CLAM6_RS16660	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CLAM6_RS16665	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CLAM6_RS16670	COG0142	geranyltranstransferase activity
CLAM6_RS16690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLAM6_RS16695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CLAM6_RS16700	COG0564	pseudouridine synthase activity
CLAM6_RS16705	COG1090	epimerase
CLAM6_RS16710	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CLAM6_RS16715	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CLAM6_RS16720	COG0789	Transcriptional regulator
CLAM6_RS16725	COG0415	Belongs to the DNA photolyase family
CLAM6_RS16735	COG0300	oxidoreductase activity
CLAM6_RS16750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CLAM6_RS16765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLAM6_RS16785	COG5001	Diguanylate cyclase
CLAM6_RS16785	COG5002	protein histidine kinase activity
CLAM6_RS16790	COG0629	single-stranded DNA binding
CLAM6_RS16795	COG2814	Major facilitator Superfamily
CLAM6_RS16805	COG0203	ribosomal protein L17
CLAM6_RS16810	COG0202	RNA polymerase activity
CLAM6_RS16815	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLAM6_RS16820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CLAM6_RS16825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CLAM6_RS16830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CLAM6_RS16840	COG0200	Binds to the 23S rRNA
CLAM6_RS16845	COG1841	ribosomal large subunit assembly
CLAM6_RS16850	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CLAM6_RS16855	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CLAM6_RS16860	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CLAM6_RS16865	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CLAM6_RS16870	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CLAM6_RS16875	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CLAM6_RS16880	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CLAM6_RS16885	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CLAM6_RS16890	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CLAM6_RS16895	COG0255	Belongs to the universal ribosomal protein uL29 family
CLAM6_RS16900	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CLAM6_RS16905	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CLAM6_RS16910	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CLAM6_RS16915	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CLAM6_RS16920	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CLAM6_RS16925	COG0089	rRNA binding
CLAM6_RS16930	COG0088	Forms part of the polypeptide exit tunnel
CLAM6_RS16935	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CLAM6_RS16940	COG0051	transcription antitermination factor activity, RNA binding
CLAM6_RS16945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLAM6_RS16950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLAM6_RS16955	COG0049	tRNA binding
CLAM6_RS16960	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CLAM6_RS16965	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CLAM6_RS16970	COG0085	RNA polymerase activity
CLAM6_RS16975	COG0222	ribosome binding
CLAM6_RS16980	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CLAM6_RS16985	COG0081	regulation of translation
CLAM6_RS16990	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CLAM6_RS17025	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CLAM6_RS17030	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CLAM6_RS17030	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CLAM6_RS17080	COG1620	l-lactate permease
CLAM6_RS17100	COG2204	response regulator
CLAM6_RS17110	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CLAM6_RS17115	COG0733	neurotransmitter:sodium symporter activity
CLAM6_RS17120	COG0339	signal peptide processing
CLAM6_RS17135	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CLAM6_RS17155	COG1953	Uracil, thiamine, allantoin
CLAM6_RS17170	COG1451	nucleotide metabolic process
CLAM6_RS17175	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CLAM6_RS17180	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CLAM6_RS17185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CLAM6_RS17190	COG0126	phosphoglycerate kinase activity
CLAM6_RS17200	COG0023	Translation Initiation Factor
CLAM6_RS17220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLAM6_RS17250	COG1217	gtp-binding protein TYPA
CLAM6_RS17260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLAM6_RS17285	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CLAM6_RS17295	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CLAM6_RS17300	COG0708	Exodeoxyribonuclease III
CLAM6_RS17305	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CLAM6_RS17310	COG1561	YicC-like family, N-terminal region
CLAM6_RS17320	COG1764	response to oxidative stress
CLAM6_RS17325	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLAM6_RS17330	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLAM6_RS17340	COG2814	Major facilitator Superfamily
CLAM6_RS17345	COG0194	GDP metabolic process
CLAM6_RS17350	COG1758	RNA polymerase activity
CLAM6_RS17355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLAM6_RS17375	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CLAM6_RS17380	COG1289	transmembrane transporter activity
CLAM6_RS17405	COG3161	chorismate lyase activity
CLAM6_RS17410	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CLAM6_RS17425	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CLAM6_RS17430	COG0704	Plays a role in the regulation of phosphate uptake
CLAM6_RS17435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLAM6_RS17440	COG0573	inorganic phosphate transmembrane transporter activity
CLAM6_RS17445	COG0573	inorganic phosphate transmembrane transporter activity
CLAM6_RS17455	COG1607	acyl-coa hydrolase
CLAM6_RS17460	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CLAM6_RS17465	COG0210	DNA helicase
CLAM6_RS17470	COG1737	Transcriptional regulator
CLAM6_RS17480	COG0733	neurotransmitter:sodium symporter activity
CLAM6_RS17495	COG1187	pseudouridine synthase activity
CLAM6_RS17500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CLAM6_RS17505	COG1349	DNA-binding transcription factor activity
CLAM6_RS17510	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CLAM6_RS17515	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CLAM6_RS17520	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CLAM6_RS17525	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CLAM6_RS17530	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CLAM6_RS17535	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLAM6_RS17540	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CLAM6_RS17550	COG0356	it plays a direct role in the translocation of protons across the membrane
CLAM6_RS17555	COG3312	ion transport
CLAM6_RS17560	COG1475	DNA binding
CLAM6_RS17565	COG1192	Involved in chromosome partitioning
CLAM6_RS17570	COG0357	Ribosomal RNA small subunit methyltransferase G
CLAM6_RS17575	COG0445	tRNA wobble uridine modification
CLAM6_RS17585	COG1126	abc transporter atp-binding protein
CLAM6_RS17590	COG0765	amino acid transport
CLAM6_RS17595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLAM6_RS17600	COG0316	Belongs to the HesB IscA family
CLAM6_RS17605	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CLAM6_RS17610	COG0038	chloride channel
CLAM6_RS17615	COG1981	membrane
CLAM6_RS17625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CLAM6_RS17670	COG2197	response regulator
CLAM6_RS17675	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CLAM6_RS17680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLAM6_RS17685	COG2885	chlorophyll binding
CLAM6_RS17690	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CLAM6_RS17695	COG1132	(ABC) transporter
CLAM6_RS17700	COG1132	(ABC) transporter
CLAM6_RS17705	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CLAM6_RS17710	COG0706	membrane insertase activity
CLAM6_RS17715	COG0594	ribonuclease P activity
CLAM6_RS17720	COG0230	Belongs to the bacterial ribosomal protein bL34 family