locus-tag	class	description
BB497_RS00010	COG3128	pkhd-type hydroxylase
BB497_RS00015	COG4774	siderophore transport
BB497_RS00030	COG1854	S-ribosylhomocysteine lyase activity
BB497_RS00045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BB497_RS00050	COG1012	belongs to the aldehyde dehydrogenase family
BB497_RS00055	COG1522	sequence-specific DNA binding
BB497_RS00060	COG3608	succinylglutamate desuccinylase aspartoacylase
BB497_RS00065	COG0006	proline dipeptidase activity
BB497_RS00070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BB497_RS00080	COG2431	L-lysine efflux transmembrane transporter activity
BB497_RS00085	COG0700	Nucleoside recognition
BB497_RS00100	COG1944	ATP diphosphatase activity
BB497_RS00105	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BB497_RS00105	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BB497_RS00110	COG0306	phosphate transporter
BB497_RS00115	COG1392	Phosphate transport regulator
BB497_RS00125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BB497_RS00135	COG0009	L-threonylcarbamoyladenylate synthase
BB497_RS00140	COG0613	PHP domain protein
BB497_RS00145	COG2350	Protein conserved in bacteria
BB497_RS00150	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BB497_RS00150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BB497_RS00160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BB497_RS00165	COG3115	cell septum assembly
BB497_RS00170	COG1196	nuclear chromosome segregation
BB497_RS00180	COG3088	subunit of a heme lyase
BB497_RS00195	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BB497_RS00215	COG4133	protoheme IX ABC transporter activity
BB497_RS00225	COG1739	Uncharacterized protein family UPF0029
BB497_RS00230	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BB497_RS00265	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BB497_RS00270	COG0527	aspartate kinase activity
BB497_RS00275	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BB497_RS00280	COG2137	regulation of response to DNA damage stimulus
BB497_RS00285	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BB497_RS00290	COG1546	Belongs to the CinA family
BB497_RS00295	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BB497_RS00305	COG0148	phosphopyruvate hydratase activity
BB497_RS00315	COG0504	CTP synthase activity
BB497_RS00320	COG0493	'glutamate synthase
BB497_RS00325	COG0070	glutamate synthase
BB497_RS00325	COG0069	glutamate synthase activity
BB497_RS00325	COG0067	glutamate synthase
BB497_RS00330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BB497_RS00335	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BB497_RS00385	COG0579	oxidoreductase
BB497_RS00390	COG1802	Transcriptional regulator
BB497_RS00395	COG1960	acyl-CoA dehydrogenase activity
BB497_RS00400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BB497_RS00405	COG5001	Diguanylate cyclase
BB497_RS00405	COG3300	MHYT domain
BB497_RS00430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BB497_RS00435	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BB497_RS00440	COG2094	Belongs to the DNA glycosylase MPG family
BB497_RS00445	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BB497_RS00450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BB497_RS00475	COG1234	tRNA 3'-trailer cleavage
BB497_RS00540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BB497_RS00545	COG2423	ornithine cyclodeaminase activity
BB497_RS00565	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BB497_RS00570	COG0343	queuine tRNA-ribosyltransferase activity
BB497_RS00575	COG1862	Preprotein translocase
BB497_RS00600	COG1045	serine acetyltransferase
BB497_RS00610	COG1104	cysteine desulfurase activity
BB497_RS00615	COG0316	Belongs to the HesB IscA family
BB497_RS00620	COG0105	UTP biosynthetic process
BB497_RS00625	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BB497_RS00640	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BB497_RS00645	COG0124	histidyl-tRNA synthetase
BB497_RS00650	COG2976	Protein conserved in bacteria
BB497_RS00660	COG1160	GTP binding
BB497_RS00685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BB497_RS00690	COG0408	coproporphyrinogen oxidase activity
BB497_RS00695	COG0009	L-threonylcarbamoyladenylate synthase
BB497_RS00700	COG0758	DNA mediated transformation
BB497_RS00710	COG0242	peptide deformylase activity
BB497_RS00715	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BB497_RS00725	COG3360	Dodecin
BB497_RS00730	COG0569	domain protein
BB497_RS00735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BB497_RS00745	COG3148	PFAM DTW domain containing protein
BB497_RS00750	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BB497_RS00755	COG0156	8-amino-7-oxononanoate synthase activity
BB497_RS00760	COG0596	Alpha beta hydrolase
BB497_RS00765	COG1073	alpha beta
BB497_RS00765	COG2226	methyltransferase
BB497_RS00770	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BB497_RS00780	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BB497_RS00785	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BB497_RS00790	COG2986	histidine ammonia-lyase
BB497_RS00820	COG2226	methyltransferase
BB497_RS00845	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BB497_RS00850	COG0564	pseudouridine synthase activity
BB497_RS00855	COG2032	superoxide dismutase activity
BB497_RS00875	COG0795	lipopolysaccharide-transporting ATPase activity
BB497_RS00880	COG0795	lipopolysaccharide-transporting ATPase activity
BB497_RS00885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BB497_RS00890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BB497_RS00925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BB497_RS00930	COG0525	valine-tRNA ligase activity
BB497_RS00935	COG2175	clavaminate synthase activity
BB497_RS00940	COG1073	alpha beta
BB497_RS00945	COG0702	epimerase
BB497_RS00955	COG4134	Bacterial extracellular solute-binding protein
BB497_RS00960	COG4135	transport system, permease component
BB497_RS00965	COG4136	ATPase activity
BB497_RS00980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BB497_RS00995	COG0346	lactoylglutathione lyase activity
BB497_RS01040	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BB497_RS01050	COG0248	Ppx GppA phosphatase
BB497_RS01055	COG0037	tRNA processing
BB497_RS01060	COG0825	malonyl-CoA metabolic process
BB497_RS01070	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BB497_RS01075	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BB497_RS01080	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BB497_RS01085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BB497_RS01090	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BB497_RS01110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BB497_RS01125	COG0233	cytoplasmic translational termination
BB497_RS01130	COG0528	UMP kinase activity
BB497_RS01135	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BB497_RS01140	COG0052	Belongs to the universal ribosomal protein uS2 family
BB497_RS01150	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BB497_RS01165	COG2171	N-acyltransferase activity
BB497_RS01170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BB497_RS01190	COG0686	Belongs to the AlaDH PNT family
BB497_RS01205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BB497_RS01210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BB497_RS01215	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BB497_RS01220	COG2003	Belongs to the UPF0758 family
BB497_RS01225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BB497_RS01230	COG0756	dUTP diphosphatase activity
BB497_RS01240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BB497_RS01245	COG1309	transcriptional regulator
BB497_RS01255	COG2177	Part of the ABC transporter FtsEX involved in
BB497_RS01260	COG2884	Cell division ATP-binding protein ftsE
BB497_RS01265	COG0552	protein localization to endoplasmic reticulum
BB497_RS01270	COG0742	ribosomal rna small subunit methyltransferase
BB497_RS01295	COG2814	Major facilitator Superfamily
BB497_RS01305	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BB497_RS01325	COG2217	Heavy metal translocating P-type atpase
BB497_RS01335	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BB497_RS01350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BB497_RS01360	COG0335	large ribosomal subunit rRNA binding
BB497_RS01365	COG0336	Belongs to the RNA methyltransferase TrmD family
BB497_RS01370	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BB497_RS01375	COG0228	four-way junction DNA binding
BB497_RS01380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BB497_RS01385	COG4137	Cytochrome C assembly protein
BB497_RS01390	COG4536	flavin adenine dinucleotide binding
BB497_RS01410	COG1025	Belongs to the peptidase M16 family
BB497_RS01415	COG2925	Exonuclease
BB497_RS01420	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BB497_RS01425	COG2894	cell division
BB497_RS01430	COG0850	regulation of cytokinetic process
BB497_RS01440	COG1028	Short-chain dehydrogenase reductase Sdr
BB497_RS01490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BB497_RS01495	COG1960	acyl-CoA dehydrogenase activity
BB497_RS01500	COG0583	DNA-binding transcription factor activity
BB497_RS01545	COG0840	transmembrane signaling receptor activity
BB497_RS01565	COG0840	transmembrane signaling receptor activity
BB497_RS01570	COG0840	transmembrane signaling receptor activity
BB497_RS01600	COG0840	transmembrane signaling receptor activity
BB497_RS01615	COG2199	diguanylate cyclase activity
BB497_RS01615	COG2202	Pas domain
BB497_RS01615	COG2200	EAL domain
BB497_RS01620	COG5002	protein histidine kinase activity
BB497_RS01620	COG2198	Histidine kinase
BB497_RS01620	COG0784	Response regulator, receiver
BB497_RS01625	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BB497_RS01635	COG0784	Response regulator, receiver
BB497_RS01635	COG2198	Histidine kinase
BB497_RS01635	COG5002	protein histidine kinase activity
BB497_RS01645	COG2205	protein histidine kinase activity
BB497_RS01645	COG3437	response regulator, receiver
BB497_RS01645	COG3850	Histidine kinase
BB497_RS01645	COG4999	Histidine kinase
BB497_RS01745	COG2205	protein histidine kinase activity
BB497_RS01745	COG0784	Response regulator, receiver
BB497_RS01745	COG2198	Histidine kinase
BB497_RS01750	COG3437	response regulator, receiver
BB497_RS01760	COG5002	protein histidine kinase activity
BB497_RS01760	COG0784	Response regulator, receiver
BB497_RS01760	COG2198	Histidine kinase
BB497_RS01765	COG5002	protein histidine kinase activity
BB497_RS01775	COG0745	RESPONSE REGULATOR receiver
BB497_RS01785	COG0596	Alpha beta hydrolase
BB497_RS01795	COG0667	Aldo Keto reductase
BB497_RS01800	COG0429	hydrolase of the alpha beta-hydrolase fold
BB497_RS01820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BB497_RS01830	COG0402	S-adenosylhomocysteine deaminase activity
BB497_RS01835	COG2252	PERMEase
BB497_RS01860	COG1959	2 iron, 2 sulfur cluster binding
BB497_RS01915	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BB497_RS01920	COG1047	Peptidyl-prolyl cis-trans
BB497_RS01930	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BB497_RS01935	COG0196	riboflavin kinase activity
BB497_RS01945	COG0268	Binds directly to 16S ribosomal RNA
BB497_RS01960	COG3118	belongs to the thioredoxin family
BB497_RS01965	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BB497_RS01975	COG1403	HNH endonuclease
BB497_RS02015	COG0667	Aldo Keto reductase
BB497_RS02020	COG3022	response to hydroperoxide
BB497_RS02065	COG1183	phosphatidylcholine synthase activity
BB497_RS02070	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BB497_RS02080	COG0440	acetolactate synthase activity
BB497_RS02085	COG0028	Belongs to the TPP enzyme family
BB497_RS02110	COG0840	transmembrane signaling receptor activity
BB497_RS02120	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BB497_RS02120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BB497_RS02140	COG0492	ferredoxin-NADP+ reductase activity
BB497_RS02155	COG2391	methyltransferase activity
BB497_RS02165	COG5001	Diguanylate cyclase
BB497_RS02165	COG3300	MHYT domain
BB497_RS02190	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BB497_RS02195	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BB497_RS02220	COG0842	Transport permease protein
BB497_RS02225	COG1131	(ABC) transporter
BB497_RS02230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BB497_RS02245	COG1185	polyribonucleotide nucleotidyltransferase activity
BB497_RS02250	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BB497_RS02255	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BB497_RS02260	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BB497_RS02265	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BB497_RS02270	COG0195	Participates in both transcription termination and antitermination
BB497_RS02275	COG0779	Required for maturation of 30S ribosomal subunits
BB497_RS02290	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BB497_RS02295	COG0149	triose-phosphate isomerase activity
BB497_RS02300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BB497_RS02305	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BB497_RS02315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BB497_RS02320	COG0601	transmembrane transport
BB497_RS02330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BB497_RS02335	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BB497_RS02360	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BB497_RS02370	COG0484	heat shock protein binding
BB497_RS02375	COG0443	Heat shock 70 kDa protein
BB497_RS02380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BB497_RS02385	COG0497	DNA recombination
BB497_RS02395	COG1279	arginine transmembrane transporter activity
BB497_RS02405	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BB497_RS02410	COG2914	Belongs to the UPF0125 (RnfH) family
BB497_RS02415	COG2867	negative regulation of translational initiation
BB497_RS02420	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BB497_RS02450	COG0583	DNA-binding transcription factor activity
BB497_RS02485	COG4251	negative regulation of phosphorylation
BB497_RS02485	COG5001	Diguanylate cyclase
BB497_RS02485	COG3706	GGDEF domain
BB497_RS02485	COG2203	Gaf domain
BB497_RS02490	COG0791	NLP P60 protein
BB497_RS02505	COG3639	organic phosphonate transmembrane transporter activity
BB497_RS02510	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BB497_RS02525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BB497_RS02540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BB497_RS02545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BB497_RS02550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BB497_RS02555	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BB497_RS02560	COG0142	geranyltranstransferase activity
BB497_RS02640	COG1175	transmembrane transport
BB497_RS02650	COG3842	ATPase activity
BB497_RS02665	COG0671	phosphoesterase, PA-phosphatase related
BB497_RS02675	COG5510	response to toxic substance
BB497_RS02760	COG1121	(ABC) transporter
BB497_RS02770	COG0803	Belongs to the bacterial solute-binding protein 9 family
BB497_RS02800	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BB497_RS02805	COG0352	thiamine-phosphate diphosphorylase activity
BB497_RS02810	COG0826	peptidase U32
BB497_RS02815	COG0697	spore germination
BB497_RS02820	COG1686	Belongs to the peptidase S11 family
BB497_RS02825	COG0203	ribosomal protein L17
BB497_RS02830	COG0202	RNA polymerase activity
BB497_RS02835	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BB497_RS02840	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BB497_RS02845	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BB497_RS02850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BB497_RS02860	COG0200	Binds to the 23S rRNA
BB497_RS02865	COG1841	ribosomal large subunit assembly
BB497_RS02870	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BB497_RS02875	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BB497_RS02880	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BB497_RS02885	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BB497_RS02890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BB497_RS02895	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BB497_RS02900	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BB497_RS02905	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BB497_RS02910	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BB497_RS02915	COG0255	Belongs to the universal ribosomal protein uL29 family
BB497_RS02920	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BB497_RS02925	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BB497_RS02930	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BB497_RS02935	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BB497_RS02940	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BB497_RS02945	COG0089	rRNA binding
BB497_RS02950	COG0088	Forms part of the polypeptide exit tunnel
BB497_RS02955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BB497_RS02960	COG0051	transcription antitermination factor activity, RNA binding
BB497_RS02965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BB497_RS02970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BB497_RS02975	COG0049	tRNA binding
BB497_RS02980	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BB497_RS02985	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BB497_RS02990	COG0085	RNA polymerase activity
BB497_RS02995	COG0222	ribosome binding
BB497_RS03000	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BB497_RS03005	COG0081	regulation of translation
BB497_RS03010	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BB497_RS03020	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BB497_RS03045	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BB497_RS03050	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BB497_RS03050	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BB497_RS03070	COG0733	neurotransmitter:sodium symporter activity
BB497_RS03085	COG0559	Belongs to the binding-protein-dependent transport system permease family
BB497_RS03095	COG0840	transmembrane signaling receptor activity
BB497_RS03110	COG0471	metal ion transport
BB497_RS03115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BB497_RS03120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BB497_RS03125	COG1090	epimerase
BB497_RS03130	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BB497_RS03150	COG0300	oxidoreductase activity
BB497_RS03165	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BB497_RS03180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BB497_RS03200	COG0629	single-stranded DNA binding
BB497_RS03205	COG2814	Major facilitator Superfamily
BB497_RS03250	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BB497_RS03255	COG1191	sigma factor activity
BB497_RS03285	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BB497_RS03290	COG0745	RESPONSE REGULATOR receiver
BB497_RS03295	COG0840	transmembrane signaling receptor activity
BB497_RS03300	COG2201	protein-glutamate methylesterase activity
BB497_RS03305	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BB497_RS03310	COG0840	transmembrane signaling receptor activity
BB497_RS03320	COG0835	chemotaxis
BB497_RS03325	COG2198	Histidine kinase
BB497_RS03325	COG0643	Histidine kinase
BB497_RS03330	COG1360	Flagellar Motor Protein
BB497_RS03370	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BB497_RS03375	COG1334	flagellar protein FlaG
BB497_RS03385	COG1766	The M ring may be actively involved in energy transduction
BB497_RS03405	COG2882	bacterial-type flagellum organization
BB497_RS03420	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BB497_RS03460	COG1705	Flagellar rod assembly protein muramidase FlgJ
BB497_RS03460	COG3951	Flagellar rod assembly protein muramidase FlgJ
BB497_RS03465	COG1706	bacterial-type flagellum-dependent cell motility
BB497_RS03480	COG4787	bacterial-type flagellum-dependent cell motility
BB497_RS03495	COG1558	bacterial-type flagellum-dependent cell motility
BB497_RS03540	COG1304	FMN binding
BB497_RS03565	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BB497_RS03570	COG0733	neurotransmitter:sodium symporter activity
BB497_RS03575	COG0339	signal peptide processing
BB497_RS03595	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BB497_RS03605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BB497_RS03610	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BB497_RS03615	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BB497_RS03625	COG1346	cytolysis
BB497_RS03630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BB497_RS03635	COG0126	phosphoglycerate kinase activity
BB497_RS03655	COG0546	phosphoglycolate phosphatase activity
BB497_RS03660	COG0023	Translation Initiation Factor
BB497_RS03700	COG0540	Belongs to the ATCase OTCase family
BB497_RS03705	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BB497_RS03710	COG1678	Uncharacterized ACR, COG1678
BB497_RS03715	COG0189	ligase activity
BB497_RS03720	COG2996	Protein conserved in bacteria
BB497_RS03725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BB497_RS03730	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BB497_RS03735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BB497_RS03740	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BB497_RS03745	COG4942	peptidase
BB497_RS03750	COG0793	Belongs to the peptidase S41A family
BB497_RS03755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BB497_RS03760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BB497_RS03765	COG0006	proline dipeptidase activity
BB497_RS03785	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BB497_RS03790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BB497_RS03795	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BB497_RS03800	COG1519	Transferase
BB497_RS03805	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BB497_RS03805	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BB497_RS03815	COG3642	lipopolysaccharide core region biosynthetic process
BB497_RS03825	COG1215	transferase activity, transferring glycosyl groups
BB497_RS03835	COG0438	transferase activity, transferring glycosyl groups
BB497_RS03850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BB497_RS03855	COG0752	glycyl-tRNA synthetase alpha subunit
BB497_RS03860	COG0751	glycine-tRNA ligase activity
BB497_RS03870	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BB497_RS03880	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BB497_RS03890	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BB497_RS03895	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BB497_RS03900	COG0594	ribonuclease P activity
BB497_RS03905	COG0706	membrane insertase activity
BB497_RS03910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BB497_RS03915	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BB497_RS03920	COG2885	chlorophyll binding
BB497_RS03925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BB497_RS03970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BB497_RS03975	COG0351	phosphomethylpyrimidine kinase
BB497_RS03980	COG1981	membrane
BB497_RS03985	COG0038	chloride channel
BB497_RS03990	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BB497_RS03995	COG0316	Belongs to the HesB IscA family
BB497_RS04000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BB497_RS04005	COG0765	amino acid transport
BB497_RS04010	COG1126	abc transporter atp-binding protein
BB497_RS04020	COG0445	tRNA wobble uridine modification
BB497_RS04025	COG0357	Ribosomal RNA small subunit methyltransferase G
BB497_RS04030	COG1192	Involved in chromosome partitioning
BB497_RS04035	COG1475	DNA binding
BB497_RS04045	COG0356	it plays a direct role in the translocation of protons across the membrane
BB497_RS04055	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BB497_RS04060	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BB497_RS04065	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BB497_RS04070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BB497_RS04075	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BB497_RS04080	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BB497_RS04085	COG2239	Acts as a magnesium transporter
BB497_RS04090	COG1007	ATP synthesis coupled electron transport
BB497_RS04105	COG1320	monovalent cation:proton antiporter activity
BB497_RS04110	COG2212	antiporter activity
BB497_RS04130	COG2239	Acts as a magnesium transporter
BB497_RS04135	COG1968	undecaprenyl-diphosphatase activity
BB497_RS04140	COG1477	protein flavinylation
BB497_RS04145	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BB497_RS04165	COG0210	DNA helicase
BB497_RS04170	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BB497_RS04180	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BB497_RS04190	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BB497_RS04195	COG1561	YicC-like family, N-terminal region
BB497_RS04210	COG2326	polyphosphate kinase activity
BB497_RS04240	COG0194	GDP metabolic process
BB497_RS04245	COG1758	RNA polymerase activity
BB497_RS04250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BB497_RS04265	COG0583	DNA-binding transcription factor activity
BB497_RS04270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BB497_RS04275	COG1289	transmembrane transporter activity
BB497_RS04295	COG3161	chorismate lyase activity
BB497_RS04300	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BB497_RS04325	COG0704	Plays a role in the regulation of phosphate uptake
BB497_RS04330	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BB497_RS04335	COG0581	inorganic phosphate transmembrane transporter activity
BB497_RS04355	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BB497_RS04360	COG0210	DNA helicase
BB497_RS04365	COG1737	Transcriptional regulator
BB497_RS04375	COG0733	neurotransmitter:sodium symporter activity
BB497_RS04380	COG1801	Protein of unknown function DUF72
BB497_RS04385	COG4459	periplasmic nitrate reductase
BB497_RS04390	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BB497_RS04400	COG0243	molybdopterin cofactor binding
BB497_RS04410	COG3005	denitrification pathway
BB497_RS04415	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BB497_RS04420	COG1414	Transcriptional regulator
BB497_RS04425	COG3181	Tripartite tricarboxylate transporter family receptor
BB497_RS04445	COG1028	Short-chain dehydrogenase reductase Sdr
BB497_RS04450	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BB497_RS04455	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BB497_RS04475	COG0181	hydroxymethylbilane synthase activity
BB497_RS04485	COG0165	Argininosuccinate lyase
BB497_RS04495	COG0019	diaminopimelate decarboxylase activity
BB497_RS04500	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BB497_RS04510	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BB497_RS04515	COG1011	Hydrolase
BB497_RS04520	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BB497_RS04530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BB497_RS04545	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BB497_RS04565	COG1490	D-aminoacyl-tRNA deacylase activity
BB497_RS04570	COG0488	(ABC) transporter
BB497_RS04580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BB497_RS04585	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BB497_RS04590	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BB497_RS04595	COG0589	response to stress
BB497_RS04600	COG0545	Peptidyl-prolyl cis-trans isomerase
BB497_RS04625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BB497_RS04630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BB497_RS04645	COG2363	Small membrane protein
BB497_RS04650	COG0840	transmembrane signaling receptor activity
BB497_RS04660	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BB497_RS04670	COG0606	chelatase, subunit chli
BB497_RS04685	COG0004	ammonium transporteR
BB497_RS04700	COG0583	DNA-binding transcription factor activity
BB497_RS04705	COG0840	transmembrane signaling receptor activity
BB497_RS04725	COG3639	organic phosphonate transmembrane transporter activity
BB497_RS04745	COG0251	oxidation-reduction process
BB497_RS04750	COG1126	abc transporter atp-binding protein
BB497_RS04755	COG0765	amino acid transport
BB497_RS04760	COG4597	amino acid ABC transporter
BB497_RS04765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BB497_RS04770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BB497_RS04775	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BB497_RS04780	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BB497_RS04785	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BB497_RS04790	COG3706	GGDEF domain
BB497_RS04795	COG4251	negative regulation of phosphorylation
BB497_RS04800	COG2205	protein histidine kinase activity
BB497_RS04805	COG0784	Response regulator, receiver
BB497_RS04810	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BB497_RS04820	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BB497_RS04825	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BB497_RS04830	COG0142	geranyltranstransferase activity
BB497_RS04835	COG1722	exodeoxyribonuclease VII activity
BB497_RS04840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BB497_RS04845	COG1741	Belongs to the pirin family
BB497_RS04850	COG1054	Belongs to the UPF0176 family
BB497_RS04860	COG1414	Transcriptional regulator
BB497_RS04865	COG1238	metal cluster binding
BB497_RS04870	COG0668	transmembrane transport
BB497_RS04875	COG1028	Short-chain dehydrogenase reductase Sdr
BB497_RS04880	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BB497_RS04890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BB497_RS04900	COG3290	protein histidine kinase activity
BB497_RS04905	COG4565	transcriptional regulatory protein
BB497_RS04950	COG3706	GGDEF domain
BB497_RS04965	COG1999	signal sequence binding
BB497_RS04975	COG0829	nickel cation binding
BB497_RS04980	COG0831	urea catabolic process
BB497_RS04985	COG0832	Belongs to the urease beta subunit family
BB497_RS04990	COG0804	urea catabolic process
BB497_RS04995	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
BB497_RS05000	COG0830	nickel cation binding
BB497_RS05005	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BB497_RS05010	COG1959	2 iron, 2 sulfur cluster binding
BB497_RS05010	COG1295	ribonuclease BN
BB497_RS05020	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BB497_RS05020	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BB497_RS05025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BB497_RS05025	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BB497_RS05030	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BB497_RS05035	COG0277	FAD linked oxidase domain protein
BB497_RS05045	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BB497_RS05055	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BB497_RS05110	COG2897	thiosulfate sulfurtransferase activity
BB497_RS05135	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BB497_RS05150	COG0450	alkyl hydroperoxide reductase
BB497_RS05155	COG3453	Protein conserved in bacteria
BB497_RS05155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BB497_RS05160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BB497_RS05170	COG1294	oxidase, subunit
BB497_RS05175	COG1271	oxidase subunit
BB497_RS05200	COG0492	ferredoxin-NADP+ reductase activity
BB497_RS05235	COG1522	sequence-specific DNA binding
BB497_RS05245	COG0733	neurotransmitter:sodium symporter activity
BB497_RS05260	COG1522	sequence-specific DNA binding
BB497_RS05270	COG2814	Major facilitator Superfamily
BB497_RS05275	COG0625	glutathione transferase activity
BB497_RS05285	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BB497_RS05305	COG1846	Transcriptional regulator
BB497_RS05325	COG2030	dehydratase
BB497_RS05325	COG1012	belongs to the aldehyde dehydrogenase family
BB497_RS05330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BB497_RS05335	COG2151	metal-sulfur cluster biosynthetic enzyme
BB497_RS05340	COG3396	Phenylacetate-CoA oxygenase
BB497_RS05345	COG3460	Phenylacetate-CoA oxygenase
BB497_RS05350	COG3396	Phenylacetate-CoA oxygenase
BB497_RS05360	COG0183	Belongs to the thiolase family
BB497_RS05365	COG2050	protein possibly involved in aromatic compounds catabolism
BB497_RS05370	COG1250	3-hydroxyacyl-CoA dehydrogenase
BB497_RS05375	COG1024	Enoyl-CoA hydratase
BB497_RS05380	COG1024	Enoyl-CoA hydratase
BB497_RS05395	COG3327	negative regulation of DNA-templated transcription, initiation
BB497_RS05405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BB497_RS05425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BB497_RS05430	COG1121	(ABC) transporter
BB497_RS05450	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BB497_RS05475	COG0840	transmembrane signaling receptor activity
BB497_RS05485	COG2351	hydroxyisourate hydrolase activity
BB497_RS05505	COG1414	Transcriptional regulator
BB497_RS05510	COG3257	ureidoglycine aminohydrolase activity
BB497_RS05515	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
BB497_RS05520	COG3960	tartronate-semialdehyde synthase activity
BB497_RS05525	COG3622	Belongs to the hyi family
BB497_RS05530	COG2084	Dehydrogenase
BB497_RS05550	COG0148	phosphopyruvate hydratase activity
BB497_RS05565	COG3648	Uricase
BB497_RS05565	COG3195	allantoin biosynthetic process
BB497_RS05575	COG0583	DNA-binding transcription factor activity
BB497_RS05580	COG5383	Protein conserved in bacteria
BB497_RS05585	COG1278	Cold shock
BB497_RS05600	COG1132	(ABC) transporter
BB497_RS05610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BB497_RS05615	COG0348	domain, Protein
BB497_RS05625	COG0596	Alpha beta hydrolase
BB497_RS05635	COG2873	o-acetylhomoserine
BB497_RS05640	COG0010	Belongs to the arginase family
BB497_RS05675	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BB497_RS05680	COG1984	allophanate hydrolase subunit 2
BB497_RS05685	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BB497_RS05690	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BB497_RS05695	COG0583	DNA-binding transcription factor activity
BB497_RS05700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BB497_RS05710	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BB497_RS05715	COG3706	GGDEF domain
BB497_RS05735	COG3706	GGDEF domain
BB497_RS05760	COG0123	including yeast histone deacetylase and acetoin utilization protein
BB497_RS05770	COG0488	(ABC) transporter
BB497_RS05780	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
BB497_RS05800	COG0840	transmembrane signaling receptor activity
BB497_RS05810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BB497_RS05815	COG1012	belongs to the aldehyde dehydrogenase family
BB497_RS05820	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BB497_RS05845	COG0415	Belongs to the DNA photolyase family
BB497_RS05850	COG2329	Antibiotic biosynthesis monooxygenase
BB497_RS05855	COG1575	Belongs to the MenA family. Type 1 subfamily
BB497_RS05865	COG1053	succinate dehydrogenase
BB497_RS05870	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BB497_RS05880	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BB497_RS05885	COG0154	amidase activity
BB497_RS05895	COG1802	Transcriptional regulator
BB497_RS05920	COG1309	transcriptional regulator
BB497_RS05930	COG0456	acetyltransferase
BB497_RS05935	COG0402	S-adenosylhomocysteine deaminase activity
BB497_RS05960	COG1953	Uracil, thiamine, allantoin
BB497_RS05975	COG0523	cobalamin synthesis protein
BB497_RS05980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BB497_RS05985	COG0303	'Molybdopterin
BB497_RS05990	COG0746	molybdenum cofactor guanylyltransferase activity
BB497_RS05995	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BB497_RS06025	COG3383	formate dehydrogenase (NAD+) activity
BB497_RS06030	COG0437	4 iron, 4 sulfur cluster binding
BB497_RS06045	COG0521	Mo-molybdopterin cofactor biosynthetic process
BB497_RS06080	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BB497_RS06090	COG0840	transmembrane signaling receptor activity
BB497_RS06095	COG0754	glutathionylspermidine amidase activity
BB497_RS06115	COG0514	ATP-dependent DNA helicase (RecQ)
BB497_RS06120	COG0395	ABC-type sugar transport system, permease component
BB497_RS06125	COG1175	transmembrane transport
BB497_RS06130	COG1653	transport
BB497_RS06140	COG3829	transcription factor binding
BB497_RS06140	COG3290	protein histidine kinase activity
BB497_RS06150	COG3314	Sporulation integral membrane protein YlbJ
BB497_RS06160	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BB497_RS06170	COG1012	belongs to the aldehyde dehydrogenase family
BB497_RS06175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BB497_RS06200	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BB497_RS06205	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BB497_RS06210	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BB497_RS06215	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BB497_RS06220	COG0617	tRNA 3'-terminal CCA addition
BB497_RS06225	COG2204	response regulator
BB497_RS06230	COG3852	Histidine kinase
BB497_RS06235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BB497_RS06240	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BB497_RS06245	COG0436	Aminotransferase
BB497_RS06250	COG1489	DNA binding
BB497_RS06260	COG2813	Specifically methylates the guanine in position
BB497_RS06260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BB497_RS06265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BB497_RS06295	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BB497_RS06300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BB497_RS06320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BB497_RS06330	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BB497_RS06335	COG0709	Synthesizes selenophosphate from selenide and ATP
BB497_RS06340	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BB497_RS06350	COG3068	Protein conserved in bacteria
BB497_RS06360	COG0107	imidazoleglycerol-phosphate synthase activity
BB497_RS06365	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BB497_RS06370	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BB497_RS06375	COG0131	Imidazoleglycerol-phosphate dehydratase
BB497_RS06390	COG1194	a g-specific adenine glycosylase
BB497_RS06395	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BB497_RS06435	COG5285	phytanoyl-CoA dioxygenase
BB497_RS06440	COG0179	Fumarylacetoacetate (FAA) hydrolase
BB497_RS06445	COG1166	arginine decarboxylase activity
BB497_RS06460	COG1840	ABC-type Fe3 transport system, periplasmic component
BB497_RS06465	COG3842	ATPase activity
BB497_RS06475	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BB497_RS06485	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BB497_RS06490	COG1444	tRNA N-acetyltransferase activity
BB497_RS06495	COG2195	Cleaves the N-terminal amino acid of tripeptides
BB497_RS06500	COG0783	Belongs to the Dps family
BB497_RS06505	COG1929	Belongs to the glycerate kinase type-1 family
BB497_RS06555	COG1607	acyl-coa hydrolase
BB497_RS06560	COG2031	fatty acid transporter
BB497_RS06565	COG0534	Mate efflux family protein
BB497_RS06570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BB497_RS06575	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BB497_RS06585	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BB497_RS06600	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BB497_RS06630	COG3577	Aspartyl protease
BB497_RS06640	COG0745	RESPONSE REGULATOR receiver
BB497_RS06645	COG2205	protein histidine kinase activity
BB497_RS06650	COG0583	DNA-binding transcription factor activity
BB497_RS06655	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BB497_RS06670	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BB497_RS06680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BB497_RS06685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BB497_RS06690	COG0140	phosphoribosyl-ATP diphosphatase activity
BB497_RS06695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BB497_RS06715	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BB497_RS06720	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BB497_RS06730	COG0018	arginyl-trna synthetase
BB497_RS06735	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BB497_RS06740	COG0254	rRNA binding
BB497_RS06745	COG0281	malic enzyme
BB497_RS06750	COG1946	Acyl-CoA thioesterase
BB497_RS06755	COG0590	tRNA wobble adenosine to inosine editing
BB497_RS06770	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BB497_RS06780	COG1024	Enoyl-CoA hydratase
BB497_RS06785	COG1061	Type III restriction enzyme res subunit
BB497_RS06790	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BB497_RS06795	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BB497_RS06815	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BB497_RS06825	COG0425	Belongs to the sulfur carrier protein TusA family
BB497_RS06835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BB497_RS06840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BB497_RS06850	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BB497_RS06855	COG1720	tRNA m6t6A37 methyltransferase activity
BB497_RS06870	COG3023	N-Acetylmuramoyl-L-alanine amidase
BB497_RS06885	COG0563	adenylate kinase activity
BB497_RS06895	COG0742	ribosomal rna small subunit methyltransferase
BB497_RS06910	COG3091	SprT-like family
BB497_RS06915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BB497_RS06925	COG2205	protein histidine kinase activity
BB497_RS06925	COG0784	Response regulator, receiver
BB497_RS06925	COG2198	Histidine kinase
BB497_RS06935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BB497_RS06955	COG0037	tRNA processing
BB497_RS06960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BB497_RS06980	COG2217	Heavy metal translocating P-type atpase
BB497_RS06990	COG0348	domain, Protein
BB497_RS06995	COG2010	Cytochrome c
BB497_RS07010	COG3278	Belongs to the heme-copper respiratory oxidase family
BB497_RS07045	COG3193	protein, possibly involved in utilization of glycolate and propanediol
BB497_RS07050	COG0247	lactate metabolic process
BB497_RS07055	COG0277	FAD linked oxidase domain protein
BB497_RS07060	COG0277	FAD linked oxidase domain protein
BB497_RS07065	COG2186	Transcriptional regulator
BB497_RS07075	COG1620	l-lactate permease
BB497_RS07095	COG2351	hydroxyisourate hydrolase activity
BB497_RS07100	COG0469	pyruvate kinase activity
BB497_RS07115	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BB497_RS07130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BB497_RS07175	COG0446	pyridine nucleotide-disulphide oxidoreductase
BB497_RS07205	COG0784	Response regulator, receiver
BB497_RS07205	COG2205	protein histidine kinase activity
BB497_RS07220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BB497_RS07225	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BB497_RS07240	COG0745	RESPONSE REGULATOR receiver
BB497_RS07245	COG2205	protein histidine kinase activity
BB497_RS07250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BB497_RS07260	COG1309	transcriptional regulator
BB497_RS07270	COG1570	exodeoxyribonuclease VII activity
BB497_RS07275	COG1283	sodium-dependent phosphate transmembrane transporter activity
BB497_RS07290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BB497_RS07290	COG0519	Catalyzes the synthesis of GMP from XMP
BB497_RS07380	COG0701	Predicted permease
BB497_RS07385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BB497_RS07420	COG2226	methyltransferase
BB497_RS07425	COG1278	Cold shock
BB497_RS07440	COG4772	TonB-dependent receptor
BB497_RS07445	COG2130	NADP-dependent
BB497_RS07450	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BB497_RS07465	COG0583	DNA-binding transcription factor activity
BB497_RS07480	COG3300	MHYT domain
BB497_RS07480	COG5001	Diguanylate cyclase
BB497_RS07490	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
BB497_RS07495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BB497_RS07495	COG0723	plastoquinol--plastocyanin reductase activity
BB497_RS07500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BB497_RS07505	COG0028	Belongs to the TPP enzyme family
BB497_RS07535	COG2146	nitrite reductase [NAD(P)H] activity
BB497_RS07535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BB497_RS07540	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BB497_RS07545	COG0243	molybdopterin cofactor binding
BB497_RS07555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BB497_RS07555	COG1648	precorrin-2 dehydrogenase activity
BB497_RS07560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BB497_RS07590	COG3181	Tripartite tricarboxylate transporter family receptor
BB497_RS07595	COG2059	Chromate
BB497_RS07600	COG2059	Chromate
BB497_RS07625	COG1280	lysine exporter protein (LysE YggA)
BB497_RS07630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BB497_RS07635	COG4221	oxidoreductase activity
BB497_RS07640	COG3707	response regulator
BB497_RS07645	COG2223	nitrite transmembrane transporter activity
BB497_RS07665	COG2989	Protein conserved in bacteria
BB497_RS07670	COG0739	heme binding
BB497_RS07675	COG0583	DNA-binding transcription factor activity
BB497_RS07680	COG0435	Glutathione S-transferase
BB497_RS07690	COG3237	CsbD-like
BB497_RS07700	COG1515	deoxyribonuclease V activity
BB497_RS07705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BB497_RS07705	COG0519	Catalyzes the synthesis of GMP from XMP
BB497_RS07715	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BB497_RS07725	COG0668	transmembrane transport
BB497_RS07735	COG0484	heat shock protein binding
BB497_RS07745	COG0517	IMP dehydrogenase activity
BB497_RS07750	COG0295	cytidine deaminase activity
BB497_RS07755	COG0813	purine-nucleoside phosphorylase activity
BB497_RS07760	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BB497_RS07765	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BB497_RS07775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BB497_RS07780	COG1349	DNA-binding transcription factor activity
BB497_RS07785	COG0109	protoheme IX farnesyltransferase activity
BB497_RS07790	COG0280	phosphate acetyltransferase
BB497_RS07790	COG0857	belongs to the CobB CobQ family
BB497_RS07795	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BB497_RS07820	COG1063	alcohol dehydrogenase
BB497_RS07825	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BB497_RS07830	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BB497_RS07835	COG4974	Belongs to the 'phage' integrase family
BB497_RS07880	COG4115	mRNA cleavage
BB497_RS07885	COG2161	toxin-antitoxin pair type II binding
BB497_RS07910	COG0656	L-ascorbic acid biosynthetic process
BB497_RS07945	COG1396	sequence-specific DNA binding
BB497_RS07960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BB497_RS07965	COG0471	metal ion transport
BB497_RS07970	COG0420	3'-5' exonuclease activity
BB497_RS07975	COG0419	ATPase involved in DNA repair
BB497_RS07985	COG1012	belongs to the aldehyde dehydrogenase family
BB497_RS07990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BB497_RS07995	COG0583	DNA-binding transcription factor activity
BB497_RS08010	COG1278	Cold shock
BB497_RS08015	COG0471	metal ion transport
BB497_RS08015	COG3273	potassium ion transport
BB497_RS08030	COG0651	ATP synthesis coupled electron transport
BB497_RS08035	COG0651	ATP synthesis coupled electron transport
BB497_RS08040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BB497_RS08040	COG2111	Na H antiporter
BB497_RS08045	COG1295	ribonuclease BN
BB497_RS08050	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BB497_RS08070	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BB497_RS08075	COG0513	Belongs to the DEAD box helicase family
BB497_RS08085	COG1132	(ABC) transporter
BB497_RS08090	COG0604	alcohol dehydrogenase
BB497_RS08120	COG0217	transcriptional regulatory protein
BB497_RS08125	COG1280	lysine exporter protein (LysE YggA)
BB497_RS08130	COG0386	Belongs to the glutathione peroxidase family
BB497_RS08140	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BB497_RS08155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BB497_RS08170	COG1012	belongs to the aldehyde dehydrogenase family
BB497_RS08175	COG3724	N-succinylarginine dihydrolase activity
BB497_RS08205	COG0438	transferase activity, transferring glycosyl groups
BB497_RS08220	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BB497_RS08235	COG2943	transferase activity, transferring hexosyl groups
BB497_RS08240	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BB497_RS08285	COG1960	acyl-CoA dehydrogenase activity
BB497_RS08295	COG0318	PFAM AMP-dependent synthetase and ligase
BB497_RS08300	COG1250	3-hydroxyacyl-CoA dehydrogenase
BB497_RS08305	COG1024	Enoyl-CoA hydratase
BB497_RS08310	COG4681	YaeQ
BB497_RS08325	COG0625	glutathione transferase activity
BB497_RS08330	COG1794	racemase activity, acting on amino acids and derivatives
BB497_RS08335	COG1764	response to oxidative stress
BB497_RS08340	COG1846	Transcriptional regulator
BB497_RS08350	COG3181	Tripartite tricarboxylate transporter family receptor
BB497_RS08360	COG3265	gluconokinase activity
BB497_RS08365	COG1609	Transcriptional regulator
BB497_RS08380	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BB497_RS08390	COG1764	response to oxidative stress
BB497_RS08405	COG4566	intracellular signal transduction
BB497_RS08410	COG0745	RESPONSE REGULATOR receiver
BB497_RS08410	COG2205	protein histidine kinase activity
BB497_RS08410	COG4191	Histidine kinase
BB497_RS08430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BB497_RS08435	COG1538	Outer membrane efflux protein
BB497_RS08440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BB497_RS08475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BB497_RS08510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BB497_RS08525	COG2084	Dehydrogenase
BB497_RS08535	COG2009	succinate dehydrogenase
BB497_RS08540	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BB497_RS08545	COG1053	succinate dehydrogenase
BB497_RS08615	COG1175	transmembrane transport
BB497_RS08620	COG0395	ABC-type sugar transport system, permease component
BB497_RS08625	COG3842	ATPase activity
BB497_RS08630	COG3768	UPF0283 membrane protein
BB497_RS08635	COG3106	COG3106 Predicted ATPase
BB497_RS08645	COG0676	glucose-6-phosphate 1-epimerase activity
BB497_RS08660	COG0791	NLP P60 protein
BB497_RS08665	COG2814	Major facilitator Superfamily
BB497_RS08670	COG1124	(ABC) transporter
BB497_RS08685	COG0601	transmembrane transport
BB497_RS08690	COG0747	negative chemotaxis
BB497_RS08725	COG2850	peptidyl-arginine hydroxylation
BB497_RS08735	COG2915	High frequency lysogenization protein hflD homolog
BB497_RS08740	COG0482	sulfurtransferase activity
BB497_RS08750	COG1187	pseudouridine synthase activity
BB497_RS08765	COG0542	response to heat
BB497_RS08775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BB497_RS08780	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BB497_RS08785	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BB497_RS08790	COG1674	ftsk spoiiie
BB497_RS08795	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BB497_RS08800	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BB497_RS08810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BB497_RS08815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BB497_RS08820	COG2902	Dehydrogenase
BB497_RS08825	COG0167	dihydroorotate dehydrogenase activity
BB497_RS08830	COG3130	regulation of translation
BB497_RS08835	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BB497_RS08835	COG0116	Belongs to the methyltransferase superfamily
BB497_RS08850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BB497_RS08855	COG0501	Belongs to the peptidase M48B family
BB497_RS08860	COG0436	Aminotransferase
BB497_RS08865	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BB497_RS08870	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BB497_RS08915	COG1131	(ABC) transporter
BB497_RS08920	COG0842	Transport permease protein
BB497_RS08925	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BB497_RS08925	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BB497_RS08950	COG1879	ABC-type sugar transport system periplasmic component
BB497_RS08955	COG1172	Belongs to the binding-protein-dependent transport system permease family
BB497_RS08960	COG1172	Belongs to the binding-protein-dependent transport system permease family
BB497_RS08965	COG1129	ABC transporter
BB497_RS08970	COG1454	alcohol dehydrogenase
BB497_RS08975	COG0402	S-adenosylhomocysteine deaminase activity
BB497_RS08980	COG2084	Dehydrogenase
BB497_RS08985	COG3485	protocatechuate 3,4-dioxygenase
BB497_RS09010	COG3246	L-lysine catabolic process to acetate
BB497_RS09040	COG0477	Major facilitator Superfamily
BB497_RS09045	COG0733	neurotransmitter:sodium symporter activity
BB497_RS09055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BB497_RS09060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BB497_RS09080	COG2840	Smr protein MutS2
BB497_RS09090	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BB497_RS09105	COG3243	poly(R)-hydroxyalkanoic acid synthase
BB497_RS09115	COG4535	Mg2 and Co2 transporter CorC
BB497_RS09120	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BB497_RS09125	COG1702	phosphate starvation-inducible protein PhoH
BB497_RS09130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BB497_RS09175	COG0640	Transcriptional regulator
BB497_RS09185	COG1362	aminopeptidase activity
BB497_RS09195	COG0012	GTP binding
BB497_RS09200	COG0193	aminoacyl-tRNA hydrolase activity
BB497_RS09205	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BB497_RS09210	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BB497_RS09220	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BB497_RS09225	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BB497_RS09235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BB497_RS09240	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BB497_RS09245	COG2890	protein-(glutamine-N5) methyltransferase activity
BB497_RS09255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BB497_RS09275	COG3842	ATPase activity
BB497_RS09280	COG1176	ABC-type spermidine putrescine transport system, permease component I
BB497_RS09285	COG1177	transmembrane transport
BB497_RS09300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BB497_RS09310	COG2081	HI0933 family
BB497_RS09325	COG4575	ribosome binding
BB497_RS09335	COG1196	nuclear chromosome segregation
BB497_RS09335	COG3264	Mechanosensitive ion channel
BB497_RS09340	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BB497_RS09355	COG4991	sh3 domain protein
BB497_RS09360	COG0500	methyltransferase
BB497_RS09375	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BB497_RS09380	COG4208	sulfate ABC transporter
BB497_RS09395	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BB497_RS09400	COG1252	NADH dehydrogenase
BB497_RS09405	COG0546	phosphoglycolate phosphatase activity
BB497_RS09415	COG0583	DNA-binding transcription factor activity
BB497_RS09420	COG1012	belongs to the aldehyde dehydrogenase family
BB497_RS09430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BB497_RS09445	COG0251	oxidation-reduction process
BB497_RS09455	COG3383	formate dehydrogenase (NAD+) activity
BB497_RS09460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BB497_RS09470	COG0039	L-malate dehydrogenase activity
BB497_RS09500	COG0730	response to heat
BB497_RS09505	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BB497_RS09510	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BB497_RS09520	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
BB497_RS09555	COG0438	transferase activity, transferring glycosyl groups
BB497_RS09560	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BB497_RS09585	COG4372	Transposase
BB497_RS09670	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BB497_RS09685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BB497_RS09690	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BB497_RS09710	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BB497_RS09720	COG0517	IMP dehydrogenase activity
BB497_RS09720	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BB497_RS09730	COG0033	Phosphoglucomutase
BB497_RS09745	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BB497_RS09750	COG1218	3'(2'),5'-bisphosphate nucleotidase
BB497_RS09765	COG1538	Outer membrane efflux protein
BB497_RS09795	COG0653	protein targeting
BB497_RS09830	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BB497_RS09835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BB497_RS09845	COG0156	8-amino-7-oxononanoate synthase activity
BB497_RS09850	COG1028	Short-chain dehydrogenase reductase Sdr
BB497_RS09850	COG3321	synthase
BB497_RS09850	COG0604	alcohol dehydrogenase
BB497_RS09875	COG3706	GGDEF domain
BB497_RS09965	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BB497_RS10010	COG0577	efflux transmembrane transporter activity
BB497_RS10015	COG4181	ATPase activity
BB497_RS10055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BB497_RS10080	COG4977	sequence-specific DNA binding
BB497_RS10095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BB497_RS10110	COG3246	L-lysine catabolic process to acetate
BB497_RS10115	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BB497_RS10120	COG0076	glutamate decarboxylase activity
BB497_RS10125	COG2985	domain, Protein
BB497_RS10140	COG1289	transmembrane transporter activity
BB497_RS10160	COG2056	Na+-H+ antiporter family
BB497_RS10165	COG2986	histidine ammonia-lyase
BB497_RS10175	COG0010	Belongs to the arginase family
BB497_RS10180	COG1228	amidohydrolase
BB497_RS10195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BB497_RS10200	COG2813	Specifically methylates the guanine in position
BB497_RS10205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BB497_RS10215	COG0494	nUDIX hydrolase
BB497_RS10220	COG3151	Protein conserved in bacteria
BB497_RS10225	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BB497_RS10235	COG0175	sulfate reduction
BB497_RS10240	COG2895	sulfate adenylyltransferase (ATP) activity
BB497_RS10250	COG1126	abc transporter atp-binding protein
BB497_RS10270	COG2738	Putative neutral zinc metallopeptidase
BB497_RS10275	COG0500	methyltransferase
BB497_RS10280	COG4106	trans-aconitate 2-methyltransferase activity
BB497_RS10285	COG0166	Belongs to the GPI family
BB497_RS10305	COG3830	Belongs to the UPF0237 family
BB497_RS10305	COG0560	Phosphoserine phosphatase
BB497_RS10330	COG1509	lysine 2,3-aminomutase activity
BB497_RS10335	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BB497_RS10340	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BB497_RS10345	COG0688	phosphatidylethanolamine metabolic process
BB497_RS10355	COG1162	GTPase activity
BB497_RS10370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BB497_RS10370	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BB497_RS10375	COG0802	atpase or kinase
BB497_RS10380	COG0860	N-Acetylmuramoyl-L-alanine amidase
BB497_RS10385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BB497_RS10390	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BB497_RS10395	COG1923	regulation of RNA biosynthetic process
BB497_RS10400	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BB497_RS10405	COG0330	HflC and HflK could
BB497_RS10410	COG0330	HflC and HflK could
BB497_RS10415	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BB497_RS10420	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BB497_RS10425	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BB497_RS10430	COG1666	GTP binding
BB497_RS10435	COG0308	aminopeptidase N
BB497_RS10440	COG1597	lipid kinase activity
BB497_RS10450	COG1278	Cold shock
BB497_RS10460	COG0741	lytic transglycosylase activity
BB497_RS10470	COG0326	Molecular chaperone. Has ATPase activity
BB497_RS10475	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BB497_RS10485	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BB497_RS10490	COG0154	amidase activity
BB497_RS10495	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BB497_RS10500	COG1077	Cell shape determining protein MreB Mrl
BB497_RS10505	COG1792	Involved in formation and maintenance of cell shape
BB497_RS10510	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BB497_RS10515	COG0424	maF-like protein
BB497_RS10530	COG0312	modulator of DNA gyrase
BB497_RS10535	COG3028	Belongs to the UPF0307 family
BB497_RS10540	COG0312	modulator of DNA gyrase
BB497_RS10545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BB497_RS10550	COG1660	Displays ATPase and GTPase activities
BB497_RS10565	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BB497_RS10570	COG1137	ATPase activity
BB497_RS10575	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BB497_RS10585	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BB497_RS10595	COG1127	ABC transporter
BB497_RS10600	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BB497_RS10605	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BB497_RS10620	COG5007	Belongs to the BolA IbaG family
BB497_RS10625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BB497_RS10630	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BB497_RS10640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BB497_RS10655	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BB497_RS10660	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BB497_RS10665	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BB497_RS10670	COG0723	plastoquinol--plastocyanin reductase activity
BB497_RS10675	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BB497_RS10680	COG2857	Cytochrome c1
BB497_RS10685	COG0625	glutathione transferase activity
BB497_RS10690	COG2969	positive regulation of protein catabolic process
BB497_RS10695	COG2823	Periplasmic or secreted lipoprotein
BB497_RS10700	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BB497_RS10705	COG0792	nuclease activity
BB497_RS10715	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BB497_RS10725	COG0275	rRNA processing
BB497_RS10730	COG3116	cell division
BB497_RS10745	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BB497_RS10750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BB497_RS10755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BB497_RS10760	COG0772	Belongs to the SEDS family
BB497_RS10765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BB497_RS10770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BB497_RS10775	COG1181	Belongs to the D-alanine--D-alanine ligase family
BB497_RS10795	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BB497_RS10815	COG0653	protein targeting
BB497_RS10825	COG0352	thiamine-phosphate diphosphorylase activity
BB497_RS10830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BB497_RS10835	COG2957	Belongs to the agmatine deiminase family
BB497_RS10845	COG1136	(ABC) transporter
BB497_RS10860	COG1132	(ABC) transporter
BB497_RS10865	COG1663	tetraacyldisaccharide 4'-kinase activity
BB497_RS10870	COG2835	tetraacyldisaccharide 4'-kinase activity
BB497_RS10875	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BB497_RS10880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BB497_RS10885	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BB497_RS10890	COG1530	ribonuclease E activity
BB497_RS10900	COG0546	phosphoglycolate phosphatase activity
BB497_RS10910	COG0424	maF-like protein
BB497_RS10915	COG1399	metal-binding, possibly nucleic acid-binding protein
BB497_RS10920	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BB497_RS10925	COG0416	fatty acid biosynthetic process
BB497_RS10940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BB497_RS10945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BB497_RS10955	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BB497_RS10960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BB497_RS10975	COG0084	hydrolase, TatD family'
BB497_RS11020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BB497_RS11030	COG1780	Probably involved in ribonucleotide reductase function
BB497_RS11035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BB497_RS11050	COG0811	peptide transport
BB497_RS11055	COG0811	peptide transport
BB497_RS11060	COG0848	biopolymer transport protein
BB497_RS11080	COG0708	Exodeoxyribonuclease III
BB497_RS11125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BB497_RS11130	COG0481	GTPase activity
BB497_RS11135	COG0681	Belongs to the peptidase S26 family
BB497_RS11140	COG0571	ribonuclease III activity
BB497_RS11150	COG1381	Involved in DNA repair and RecF pathway recombination
BB497_RS11155	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BB497_RS11160	COG0736	holo-[acyl-carrier-protein] synthase activity
BB497_RS11165	COG5002	protein histidine kinase activity
BB497_RS11165	COG2205	protein histidine kinase activity
BB497_RS11165	COG0784	Response regulator, receiver
BB497_RS11175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BB497_RS11180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BB497_RS11185	COG3956	TIGRFAM MazG family protein
BB497_RS11190	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BB497_RS11215	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
BB497_RS11225	COG2226	methyltransferase
BB497_RS11230	COG0318	PFAM AMP-dependent synthetase and ligase
BB497_RS11245	COG1024	Enoyl-CoA hydratase
BB497_RS11250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BB497_RS11255	COG1960	acyl-CoA dehydrogenase activity
BB497_RS11290	COG1960	acyl-CoA dehydrogenase activity
BB497_RS11295	COG1250	3-hydroxyacyl-CoA dehydrogenase
BB497_RS11295	COG1024	Enoyl-CoA hydratase
BB497_RS11305	COG0625	glutathione transferase activity
BB497_RS11325	COG0385	Bile acid
BB497_RS11330	COG0318	PFAM AMP-dependent synthetase and ligase
BB497_RS11335	COG0628	permease
BB497_RS11350	COG1704	LemA family
BB497_RS11355	COG0501	Belongs to the peptidase M48B family
BB497_RS11360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BB497_RS11365	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BB497_RS11370	COG0653	protein targeting
BB497_RS11375	COG2211	Major facilitator Superfamily
BB497_RS11380	COG1047	Peptidyl-prolyl cis-trans
BB497_RS11395	COG2199	diguanylate cyclase activity
BB497_RS11420	COG0741	lytic transglycosylase activity
BB497_RS11425	COG0442	prolyl-tRNA aminoacylation
BB497_RS11435	COG3135	benzoate transporter
BB497_RS11440	COG0154	amidase activity
BB497_RS11445	COG1396	sequence-specific DNA binding
BB497_RS11450	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BB497_RS11455	COG0584	glycerophosphoryl diester phosphodiesterase
BB497_RS11465	COG1737	Transcriptional regulator
BB497_RS11470	COG1024	Enoyl-CoA hydratase
BB497_RS11480	COG1024	Enoyl-CoA hydratase
BB497_RS11495	COG1349	DNA-binding transcription factor activity
BB497_RS11500	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BB497_RS11510	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BB497_RS11525	COG0395	ABC-type sugar transport system, permease component
BB497_RS11535	COG3842	ATPase activity
BB497_RS11660	COG3001	Fructosamine kinase
BB497_RS11785	COG5001	Diguanylate cyclase
BB497_RS11785	COG4251	negative regulation of phosphorylation
BB497_RS11785	COG3706	GGDEF domain
BB497_RS11785	COG2203	Gaf domain
BB497_RS11790	COG1321	iron dependent repressor
BB497_RS11800	COG1121	(ABC) transporter
BB497_RS11805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BB497_RS11845	COG2610	gluconate transmembrane transporter activity
BB497_RS11850	COG2056	Na+-H+ antiporter family
BB497_RS11860	COG3344	reverse transcriptase
BB497_RS11870	COG0459	protein refolding
BB497_RS11875	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BB497_RS11880	COG3030	protein affecting phage T7 exclusion by the F plasmid
BB497_RS11885	COG1028	Short-chain dehydrogenase reductase Sdr
BB497_RS11920	COG0302	gtp cyclohydrolase
BB497_RS11935	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BB497_RS11945	COG2264	protein methyltransferase activity
BB497_RS11955	COG0511	ligase activity, forming carbon-carbon bonds
BB497_RS11965	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BB497_RS11975	COG0205	6-phosphofructokinase activity
BB497_RS11980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BB497_RS11985	COG0137	argininosuccinate synthase activity
BB497_RS12000	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BB497_RS12005	COG5002	protein histidine kinase activity
BB497_RS12015	COG5002	protein histidine kinase activity
BB497_RS12015	COG2176	DNA-directed DNA polymerase activity
BB497_RS12030	COG1966	Carbon starvation protein
BB497_RS12040	COG0003	Pfam Anion-transporting ATPase
BB497_RS12055	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BB497_RS12060	COG4660	Part of a membrane complex involved in electron transport
BB497_RS12065	COG4659	FMN binding
BB497_RS12070	COG4658	electron transport chain
BB497_RS12075	COG4656	Part of a membrane complex involved in electron transport
BB497_RS12080	COG2878	Part of a membrane complex involved in electron transport
BB497_RS12085	COG4657	Part of a membrane complex involved in electron transport
BB497_RS12090	COG5001	Diguanylate cyclase
BB497_RS12090	COG3300	MHYT domain
BB497_RS12095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BB497_RS12095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BB497_RS12115	COG0824	Thioesterase
BB497_RS12125	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BB497_RS12130	COG0077	Prephenate dehydratase
BB497_RS12130	COG1605	Chorismate mutase
BB497_RS12135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BB497_RS12140	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BB497_RS12175	COG0237	dephospho-CoA kinase activity
BB497_RS12235	COG1611	Belongs to the LOG family
BB497_RS12240	COG0583	DNA-binding transcription factor activity
BB497_RS12250	COG0509	glycine decarboxylation via glycine cleavage system
BB497_RS12255	COG1115	amino acid carrier protein
BB497_RS12260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BB497_RS12265	COG4942	peptidase
BB497_RS12270	COG0204	Acyl-transferase
BB497_RS12275	COG0583	DNA-binding transcription factor activity
BB497_RS12280	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BB497_RS12295	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BB497_RS12305	COG1028	Short-chain dehydrogenase reductase Sdr
BB497_RS12310	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BB497_RS12315	COG2205	protein histidine kinase activity
BB497_RS12325	COG0418	dihydroorotase activity
BB497_RS12330	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BB497_RS12335	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BB497_RS12365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BB497_RS12380	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BB497_RS12385	COG0084	hydrolase, TatD family'
BB497_RS12390	COG0354	folic acid binding
BB497_RS12405	COG0556	nucleotide-excision repair
BB497_RS12410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BB497_RS12420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BB497_RS12425	COG0583	DNA-binding transcription factor activity
BB497_RS12430	COG1056	cytidyltransferase-related domain
BB497_RS12430	COG1051	belongs to the nudix hydrolase family
BB497_RS12440	COG1254	Belongs to the acylphosphatase family
BB497_RS12445	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BB497_RS12455	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BB497_RS12460	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BB497_RS12465	COG0632	four-way junction helicase activity
BB497_RS12470	COG2255	four-way junction helicase activity
BB497_RS12475	COG0824	Thioesterase
BB497_RS12495	COG0823	Involved in the tonB-independent uptake of proteins
BB497_RS12500	COG2885	chlorophyll binding
BB497_RS12510	COG1028	Short-chain dehydrogenase reductase Sdr
BB497_RS12535	COG0729	surface antigen
BB497_RS12540	COG2911	Protein conserved in bacteria
BB497_RS12545	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BB497_RS12555	COG0288	reversible hydration of carbon dioxide
BB497_RS12565	COG0456	acetyltransferase
BB497_RS12570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BB497_RS12575	COG1917	Cupin 2, conserved barrel domain protein
BB497_RS12585	COG0189	ligase activity
BB497_RS12585	COG4067	protein conserved in archaea
BB497_RS12600	COG0735	belongs to the Fur family
BB497_RS12605	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BB497_RS12610	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BB497_RS12615	COG2166	iron-sulfur cluster assembly
BB497_RS12630	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BB497_RS12630	COG0316	Belongs to the HesB IscA family
BB497_RS12640	COG0534	Mate efflux family protein
BB497_RS12645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BB497_RS12655	COG2840	Smr protein MutS2
BB497_RS12680	COG0259	pyridoxamine-phosphate oxidase activity
BB497_RS12690	COG0123	including yeast histone deacetylase and acetoin utilization protein
BB497_RS12710	COG2923	Belongs to the DsrF TusC family
BB497_RS12715	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BB497_RS12730	COG2199	diguanylate cyclase activity
BB497_RS12730	COG2203	Gaf domain
BB497_RS12735	COG3920	Histidine kinase
BB497_RS12735	COG2202	Pas domain
BB497_RS12765	COG1469	GTP cyclohydrolase I activity
BB497_RS12770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BB497_RS12775	COG0215	cysteine-tRNA ligase activity
BB497_RS12780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BB497_RS12790	COG1854	S-ribosylhomocysteine lyase activity
BB497_RS12820	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BB497_RS12840	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BB497_RS12850	COG4983	Phage plasmid primase, P4 family domain protein
BB497_RS12875	COG0582	viral genome integration into host DNA
BB497_RS12885	COG3263	regulation of cellular component size
BB497_RS12890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BB497_RS12900	COG2267	carboxylic ester hydrolase activity
BB497_RS12905	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BB497_RS12915	COG0640	Transcriptional regulator
BB497_RS12920	COG0616	signal peptide processing
BB497_RS12930	COG2816	NAD+ diphosphatase activity
BB497_RS12935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BB497_RS12940	COG0328	RNA-DNA hybrid ribonuclease activity
BB497_RS12950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BB497_RS12955	COG0741	lytic transglycosylase activity
BB497_RS12955	COG1388	LysM domain
BB497_RS12960	COG4166	transmembrane transport
BB497_RS12965	COG4174	ABC transporter (Permease)
BB497_RS12970	COG4239	(ABC) transporter, permease
BB497_RS12975	COG4172	Belongs to the ABC transporter superfamily
BB497_RS12980	COG1187	pseudouridine synthase activity
BB497_RS12990	COG2962	Rard protein
BB497_RS13000	COG0659	secondary active sulfate transmembrane transporter activity
BB497_RS13020	COG1024	Enoyl-CoA hydratase
BB497_RS13025	COG1960	acyl-CoA dehydrogenase activity
BB497_RS13030	COG1960	acyl-CoA dehydrogenase activity
BB497_RS13035	COG1024	Enoyl-CoA hydratase
BB497_RS13040	COG2070	2-Nitropropane dioxygenase
BB497_RS13065	COG0318	PFAM AMP-dependent synthetase and ligase
BB497_RS13070	COG1960	acyl-CoA dehydrogenase activity
BB497_RS13075	COG1250	3-hydroxyacyl-CoA dehydrogenase
BB497_RS13080	COG0183	Belongs to the thiolase family
BB497_RS13085	COG1414	Transcriptional regulator
BB497_RS13090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BB497_RS13110	COG0515	serine threonine protein kinase
BB497_RS13120	COG0022	dehydrogenase e1 component
BB497_RS13125	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BB497_RS13130	COG1174	glycine betaine transport
BB497_RS13135	COG1125	glycine betaine transport
BB497_RS13140	COG1174	glycine betaine transport
BB497_RS13145	COG1732	Glycine betaine
BB497_RS13150	COG0215	cysteine-tRNA ligase activity
BB497_RS13155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BB497_RS13160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BB497_RS13165	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BB497_RS13170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BB497_RS13180	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BB497_RS13185	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BB497_RS13190	COG0740	serine-type endopeptidase activity
BB497_RS13195	COG0544	peptidyl-prolyl cis-trans isomerase activity
BB497_RS13215	COG0776	regulation of translation
BB497_RS13220	COG0072	phenylalanine-tRNA ligase activity
BB497_RS13225	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BB497_RS13230	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BB497_RS13235	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BB497_RS13240	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BB497_RS13245	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BB497_RS13250	COG2885	chlorophyll binding
BB497_RS13260	COG1612	heme a metabolic process
BB497_RS13285	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BB497_RS13290	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BB497_RS13295	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BB497_RS13315	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BB497_RS13320	COG1643	Atp-dependent helicase
BB497_RS13325	COG1309	transcriptional regulator
BB497_RS13355	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BB497_RS13360	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BB497_RS13365	COG1858	cytochrome C peroxidase
BB497_RS13370	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BB497_RS13375	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BB497_RS13380	COG4988	ABC transporter
BB497_RS13385	COG1294	oxidase, subunit
BB497_RS13390	COG1271	oxidase subunit
BB497_RS13400	COG2995	paraquat-inducible protein a
BB497_RS13405	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BB497_RS13405	COG3008	intermembrane lipid transfer
BB497_RS13410	COG3009	Protein conserved in bacteria
BB497_RS13415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BB497_RS13420	COG0513	Belongs to the DEAD box helicase family
BB497_RS13430	COG2807	transmembrane transport
BB497_RS13435	COG0252	asparaginase activity
BB497_RS13455	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BB497_RS13460	COG0602	queuosine metabolic process
BB497_RS13490	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BB497_RS13495	COG0584	glycerophosphoryl diester phosphodiesterase
BB497_RS13500	COG0405	Gamma-glutamyltransferase
BB497_RS13510	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BB497_RS13515	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BB497_RS13530	COG1309	transcriptional regulator
BB497_RS13535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BB497_RS13545	COG0788	formyltetrahydrofolate deformylase activity
BB497_RS13555	COG0314	molybdopterin synthase activity
BB497_RS13560	COG0315	cyclic pyranopterin monophosphate synthase activity
BB497_RS13565	COG1763	Mo-molybdopterin cofactor biosynthetic process
BB497_RS13575	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BB497_RS13580	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BB497_RS13585	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BB497_RS13590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BB497_RS13595	COG2252	PERMEase
BB497_RS13600	COG0307	riboflavin synthase, alpha
BB497_RS13605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BB497_RS13610	COG2011	ABC-type metal ion transport system permease component
BB497_RS13615	COG1464	Belongs to the NlpA lipoprotein family
BB497_RS13620	COG1956	GAF domain-containing protein
BB497_RS13645	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BB497_RS13650	COG0628	permease
BB497_RS13655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BB497_RS13660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BB497_RS13665	COG0717	Belongs to the dCTP deaminase family
BB497_RS13670	COG0489	protein tyrosine kinase activity
BB497_RS13680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BB497_RS13680	COG1648	precorrin-2 dehydrogenase activity
BB497_RS13690	COG2154	pterin-4-alpha-carbinolamine dehydratase
BB497_RS13705	COG0534	Mate efflux family protein
BB497_RS13715	COG3038	cytochrome b561
BB497_RS13740	COG0285	dihydrofolate synthase activity
BB497_RS13745	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BB497_RS13750	COG0159	tryptophan synthase activity
BB497_RS13760	COG0135	phosphoribosylanthranilate isomerase activity
BB497_RS13780	COG0473	3-isopropylmalate dehydrogenase activity
BB497_RS13785	COG0066	3-isopropylmalate dehydratase activity
BB497_RS13790	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BB497_RS13800	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
BB497_RS13840	COG0495	leucyl-tRNA aminoacylation
BB497_RS13875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BB497_RS13890	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BB497_RS13895	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BB497_RS13900	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BB497_RS13905	COG1805	sodium ion transport
BB497_RS13910	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BB497_RS13920	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BB497_RS13925	COG1388	LysM domain
BB497_RS13925	COG1376	ErfK ybiS ycfS ynhG family protein
BB497_RS13960	COG0583	DNA-binding transcription factor activity
BB497_RS13965	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BB497_RS13970	COG0321	lipoyl(octanoyl) transferase activity
BB497_RS13975	COG2921	Belongs to the UPF0250 family
BB497_RS13980	COG1686	Belongs to the peptidase S11 family
BB497_RS13990	COG2951	lytic endotransglycosylase activity
BB497_RS13995	COG0772	Belongs to the SEDS family
BB497_RS14000	COG0768	penicillin binding
BB497_RS14005	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BB497_RS14015	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BB497_RS14020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BB497_RS14035	COG0586	Pfam SNARE associated Golgi protein
BB497_RS14040	COG1280	lysine exporter protein (LysE YggA)
BB497_RS14050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BB497_RS14060	COG0747	negative chemotaxis
BB497_RS14065	COG0601	transmembrane transport
BB497_RS14070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BB497_RS14080	COG4608	Belongs to the ABC transporter superfamily
BB497_RS14085	COG0583	DNA-binding transcription factor activity
BB497_RS14090	COG0006	proline dipeptidase activity
BB497_RS14100	COG1063	alcohol dehydrogenase
BB497_RS14105	COG2072	flavoprotein involved in K transport
BB497_RS14110	COG3284	Transcriptional regulator
BB497_RS14115	COG0542	response to heat
BB497_RS14130	COG0659	secondary active sulfate transmembrane transporter activity
BB497_RS14145	COG1492	cobalamin metabolic process
BB497_RS14155	COG2066	Belongs to the glutaminase family
BB497_RS14160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BB497_RS14165	COG1522	sequence-specific DNA binding
BB497_RS14190	COG1030	water channel activity
BB497_RS14205	COG2226	methyltransferase
BB497_RS14220	COG0513	Belongs to the DEAD box helicase family
BB497_RS14225	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BB497_RS14260	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BB497_RS14265	COG4139	cobalamin transport
BB497_RS14270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BB497_RS14275	COG4206	TonB-dependent receptor
BB497_RS14285	COG0406	alpha-ribazole phosphatase activity
BB497_RS14290	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BB497_RS14305	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BB497_RS14315	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BB497_RS14320	COG1538	Outer membrane efflux protein
BB497_RS14325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BB497_RS14340	COG0837	glucose binding
BB497_RS14350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BB497_RS14370	COG2182	Extracellular solute-binding protein
BB497_RS14380	COG3833	ABC-type maltose transport systems, permease component
BB497_RS14390	COG0366	Alpha amylase catalytic
BB497_RS14395	COG2909	trisaccharide binding
BB497_RS14405	COG1653	transport
BB497_RS14420	COG0366	Alpha amylase catalytic
BB497_RS14425	COG3842	ATPase activity
BB497_RS14430	COG1609	Transcriptional regulator
BB497_RS14440	COG0469	pyruvate kinase activity
BB497_RS14445	COG1803	Methylglyoxal synthase
BB497_RS14455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BB497_RS14455	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BB497_RS14460	COG1105	Belongs to the carbohydrate kinase PfkB family
BB497_RS14465	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BB497_RS14465	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
BB497_RS14465	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BB497_RS14470	COG0166	Belongs to the GPI family
BB497_RS14490	COG2217	Heavy metal translocating P-type atpase
BB497_RS14500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BB497_RS14505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BB497_RS14505	COG2010	Cytochrome c
BB497_RS14540	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BB497_RS14555	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BB497_RS14555	COG0617	tRNA 3'-terminal CCA addition
BB497_RS14555	COG0517	IMP dehydrogenase activity
BB497_RS14575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BB497_RS14580	COG0506	proline dehydrogenase activity
BB497_RS14580	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BB497_RS14580	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BB497_RS14585	COG3047	cAMP biosynthetic process
BB497_RS14590	COG3098	single-species biofilm formation
BB497_RS14605	COG0189	ligase activity
BB497_RS14615	COG2949	membrane
BB497_RS14625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BB497_RS14630	COG0719	Fe-S assembly protein
BB497_RS14635	COG0396	ATPase activity
BB497_RS14640	COG0719	Fe-S assembly protein
BB497_RS14655	COG2824	Alkylphosphonate utilization operon protein PhnA
BB497_RS14660	COG1881	PFAM PEBP family protein
BB497_RS14685	COG0183	Belongs to the thiolase family
BB497_RS14700	COG1846	Transcriptional regulator
BB497_RS14710	COG0589	response to stress
BB497_RS14715	COG0488	(ABC) transporter
BB497_RS14725	COG0318	PFAM AMP-dependent synthetase and ligase
BB497_RS14730	COG0183	Belongs to the thiolase family
BB497_RS14735	COG1960	acyl-CoA dehydrogenase activity
BB497_RS14740	COG0318	PFAM AMP-dependent synthetase and ligase
BB497_RS14760	COG3101	peptidyl-lysine hydroxylation
BB497_RS14790	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BB497_RS14810	COG1960	acyl-CoA dehydrogenase activity
BB497_RS14820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BB497_RS14830	COG0183	Belongs to the thiolase family
BB497_RS14840	COG0431	NADPH-dependent FMN reductase
BB497_RS14845	COG0798	PFAM Bile acid sodium symporter
BB497_RS14850	COG0431	NADPH-dependent FMN reductase
BB497_RS14885	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BB497_RS14890	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BB497_RS14895	COG0581	inorganic phosphate transmembrane transporter activity
BB497_RS14900	COG0573	inorganic phosphate transmembrane transporter activity
BB497_RS14915	COG2814	Major facilitator Superfamily
BB497_RS14920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BB497_RS14935	COG2853	Lipoprotein
BB497_RS14945	COG1643	Atp-dependent helicase
BB497_RS14950	COG0318	PFAM AMP-dependent synthetase and ligase
BB497_RS14955	COG0121	glutamine amidotransferase
BB497_RS14970	COG2983	Belongs to the UPF0260 family
BB497_RS14980	COG3100	YcgL domain-containing protein
BB497_RS14990	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BB497_RS14995	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BB497_RS15000	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BB497_RS15005	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BB497_RS15010	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BB497_RS15025	COG0322	excinuclease ABC activity
BB497_RS15050	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BB497_RS15065	COG0776	regulation of translation
BB497_RS15075	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BB497_RS15080	COG0284	orotidine-5'-phosphate decarboxylase activity
BB497_RS15100	COG0372	Belongs to the citrate synthase family
BB497_RS15105	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BB497_RS15110	COG1802	Transcriptional regulator
BB497_RS15120	COG0175	sulfate reduction
BB497_RS15130	COG3118	belongs to the thioredoxin family
BB497_RS15135	COG0628	permease
BB497_RS15145	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BB497_RS15155	COG0277	FAD linked oxidase domain protein
BB497_RS15155	COG0247	lactate metabolic process
BB497_RS15165	COG0134	indole-3-glycerol-phosphate synthase activity
BB497_RS15170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BB497_RS15175	COG0512	Glutamine amidotransferase of anthranilate synthase
BB497_RS15185	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BB497_RS15190	COG2918	glutathione biosynthetic process
BB497_RS15195	COG2183	response to ionizing radiation
BB497_RS15200	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BB497_RS15205	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BB497_RS15210	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BB497_RS15215	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BB497_RS15220	COG1011	Hydrolase
BB497_RS15225	COG0494	nUDIX hydrolase
BB497_RS15230	COG0673	inositol 2-dehydrogenase activity
BB497_RS15235	COG0129	dihydroxy-acid dehydratase activity
BB497_RS15240	COG0840	transmembrane signaling receptor activity
BB497_RS15240	COG0840	transmembrane signaling receptor activity
BB497_RS15245	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BB497_RS15255	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BB497_RS15265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BB497_RS15270	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BB497_RS15280	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BB497_RS15280	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BB497_RS15285	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BB497_RS15290	COG0366	Alpha amylase catalytic
BB497_RS15305	COG3258	Cytochrome c
BB497_RS15310	COG2863	cytochrome
BB497_RS15315	COG0642	Histidine kinase
BB497_RS15325	COG2391	methyltransferase activity
BB497_RS15330	COG2391	methyltransferase activity
BB497_RS15345	COG1215	transferase activity, transferring glycosyl groups
BB497_RS15355	COG2885	chlorophyll binding
BB497_RS15370	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BB497_RS15375	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BB497_RS15380	COG4181	ATPase activity
BB497_RS15425	COG1538	Outer membrane efflux protein
BB497_RS15445	COG1366	Belongs to the anti-sigma-factor antagonist family
BB497_RS15455	COG0488	(ABC) transporter
BB497_RS15470	COG0537	adenosine 5'-monophosphoramidase activity
BB497_RS15475	COG3954	Phosphoribulokinase
BB497_RS15485	COG0151	Belongs to the GarS family
BB497_RS15490	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
BB497_RS15495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BB497_RS15500	COG0189	ligase activity
BB497_RS15500	COG4067	protein conserved in archaea
BB497_RS15505	COG2951	lytic endotransglycosylase activity
BB497_RS15515	COG0415	Belongs to the DNA photolyase family
BB497_RS15525	COG1320	monovalent cation:proton antiporter activity
BB497_RS15530	COG2212	antiporter activity
BB497_RS15535	COG1863	multisubunit Na H antiporter MnhE subunit
BB497_RS15540	COG0651	ATP synthesis coupled electron transport
BB497_RS15545	COG1006	Multisubunit Na H antiporter MnhC subunit
BB497_RS15550	COG2111	Na H antiporter
BB497_RS15555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BB497_RS15555	COG2111	Na H antiporter
BB497_RS15565	COG2111	Na H antiporter
BB497_RS15565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BB497_RS15570	COG1006	Multisubunit Na H antiporter MnhC subunit
BB497_RS15575	COG0651	ATP synthesis coupled electron transport
BB497_RS15585	COG2212	antiporter activity
BB497_RS15590	COG1320	monovalent cation:proton antiporter activity
BB497_RS15600	COG3046	protein related to deoxyribodipyrimidine photolyase
BB497_RS15620	COG0305	Participates in initiation and elongation during chromosome replication
BB497_RS15620	COG1372	Participates in initiation and elongation during chromosome replication
BB497_RS15625	COG0359	binds to the 23S rRNA
BB497_RS15635	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BB497_RS15640	COG0360	Binds together with S18 to 16S ribosomal RNA
BB497_RS15645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BB497_RS15650	COG0557	exoribonuclease II activity
BB497_RS15685	COG2719	SpoVR family
BB497_RS15690	COG2718	Belongs to the UPF0229 family
BB497_RS15695	COG2766	serine protein kinase
BB497_RS15705	COG1902	pentaerythritol trinitrate reductase activity
BB497_RS15705	COG0446	pyridine nucleotide-disulphide oxidoreductase
BB497_RS15710	COG0697	spore germination
BB497_RS15715	COG3153	acetyltransferase
BB497_RS15715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BB497_RS15730	COG1115	amino acid carrier protein
BB497_RS15740	COG3040	lipid binding
BB497_RS15745	COG0583	DNA-binding transcription factor activity
BB497_RS15755	COG0655	NAD(P)H dehydrogenase (quinone) activity
BB497_RS15765	COG2988	succinylglutamate desuccinylase activity
BB497_RS15780	COG4160	amino acid transport
BB497_RS15795	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BB497_RS15805	COG5001	Diguanylate cyclase
BB497_RS15805	COG3300	MHYT domain
BB497_RS15815	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BB497_RS15845	COG0129	dihydroxy-acid dehydratase activity
BB497_RS15850	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BB497_RS15865	COG1074	ATP-dependent DNA helicase activity
BB497_RS15870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BB497_RS15880	COG1715	Restriction endonuclease
BB497_RS15885	COG2161	toxin-antitoxin pair type II binding
BB497_RS15890	COG2824	Alkylphosphonate utilization operon protein PhnA
BB497_RS15895	COG0259	pyridoxamine-phosphate oxidase activity
BB497_RS15915	COG2026	Addiction module toxin, RelE StbE family
BB497_RS15920	COG2161	toxin-antitoxin pair type II binding
BB497_RS15925	COG0159	tryptophan synthase activity
BB497_RS15945	COG2133	pyrroloquinoline quinone binding
BB497_RS15950	COG0584	glycerophosphoryl diester phosphodiesterase
BB497_RS15965	COG5001	Diguanylate cyclase
BB497_RS15965	COG5002	protein histidine kinase activity
BB497_RS15985	COG4106	trans-aconitate 2-methyltransferase activity
BB497_RS15990	COG1064	alcohol dehydrogenase
BB497_RS15995	COG2207	Transcriptional regulator
BB497_RS16005	COG0583	DNA-binding transcription factor activity
BB497_RS16050	COG3938	Belongs to the proline racemase family
BB497_RS16065	COG0598	Magnesium transport protein CorA
BB497_RS16100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BB497_RS16110	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BB497_RS16165	COG1132	(ABC) transporter
BB497_RS16170	COG1120	ATPase activity
BB497_RS16175	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BB497_RS16180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BB497_RS16185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BB497_RS16190	COG4771	TonB-dependent receptor
BB497_RS16195	COG0583	DNA-binding transcription factor activity
BB497_RS16205	COG2133	pyrroloquinoline quinone binding
BB497_RS16230	COG0517	IMP dehydrogenase activity
BB497_RS16230	COG4175	Glycine betaine
BB497_RS16250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BB497_RS16275	COG2199	diguanylate cyclase activity
BB497_RS16275	COG2200	EAL domain
BB497_RS16280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BB497_RS16290	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BB497_RS16295	COG0583	DNA-binding transcription factor activity
BB497_RS16300	COG1760	l-serine dehydratase
BB497_RS16310	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BB497_RS16320	COG0358	DNA primase activity
BB497_RS16325	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BB497_RS16330	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BB497_RS16335	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BB497_RS16350	COG0617	tRNA 3'-terminal CCA addition
BB497_RS16355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BB497_RS16360	COG2967	ApaG domain
BB497_RS16365	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BB497_RS16370	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BB497_RS16375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BB497_RS16380	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BB497_RS16385	COG3178	'Phosphotransferase
BB497_RS16390	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BB497_RS16395	COG1765	OsmC-like protein
BB497_RS16400	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BB497_RS16405	COG1560	Kdo2-lipid A biosynthetic process
BB497_RS16410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BB497_RS16430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BB497_RS16435	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BB497_RS16440	COG0585	pseudouridine synthase activity
BB497_RS16445	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BB497_RS16450	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BB497_RS16455	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BB497_RS16470	COG2202	Pas domain
BB497_RS16470	COG2205	protein histidine kinase activity
BB497_RS16480	COG1737	Transcriptional regulator
BB497_RS16495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BB497_RS16510	COG0589	response to stress
BB497_RS16515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BB497_RS16520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BB497_RS16530	COG0589	response to stress
BB497_RS16535	COG0659	secondary active sulfate transmembrane transporter activity
BB497_RS16540	COG0473	3-isopropylmalate dehydrogenase activity
BB497_RS16570	COG1376	ErfK ybiS ycfS ynhG family protein
BB497_RS16575	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BB497_RS16595	COG1595	DNA-templated transcription, initiation
BB497_RS16615	COG0450	alkyl hydroperoxide reductase
BB497_RS16620	COG1469	GTP cyclohydrolase I activity
BB497_RS16625	COG0523	cobalamin synthesis protein
BB497_RS16645	COG1121	(ABC) transporter