locus-tag	class	description
C8233_RS00010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C8233_RS00020	COG1132	(ABC) transporter
C8233_RS00025	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C8233_RS00060	COG3321	synthase
C8233_RS00060	COG0604	alcohol dehydrogenase
C8233_RS00060	COG1028	Short-chain dehydrogenase reductase Sdr
C8233_RS00100	COG0175	sulfate reduction
C8233_RS00170	COG1088	dTDP-glucose 4,6-dehydratase activity
C8233_RS00175	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C8233_RS00190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C8233_RS00210	COG0583	DNA-binding transcription factor activity
C8233_RS00230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C8233_RS00245	COG1063	alcohol dehydrogenase
C8233_RS00250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C8233_RS00255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C8233_RS00275	COG0753	catalase activity
C8233_RS00280	COG0666	response to abiotic stimulus
C8233_RS00300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C8233_RS00310	COG2375	cellular response to nickel ion
C8233_RS00350	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C8233_RS00355	COG1312	Catalyzes the dehydration of D-mannonate
C8233_RS00365	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C8233_RS00380	COG1609	Transcriptional regulator
C8233_RS00390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C8233_RS00420	COG2186	Transcriptional regulator
C8233_RS00425	COG0659	secondary active sulfate transmembrane transporter activity
C8233_RS00435	COG2188	Transcriptional regulator
C8233_RS00450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C8233_RS00455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C8233_RS00460	COG0583	DNA-binding transcription factor activity
C8233_RS00465	COG2936	dipeptidyl-peptidase activity
C8233_RS00470	COG1012	belongs to the aldehyde dehydrogenase family
C8233_RS00480	COG0583	DNA-binding transcription factor activity
C8233_RS00485	COG0583	DNA-binding transcription factor activity
C8233_RS00495	COG0625	glutathione transferase activity
C8233_RS00500	COG1017	nitric oxide dioxygenase activity
C8233_RS00500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C8233_RS00520	COG1620	l-lactate permease
C8233_RS00530	COG0697	spore germination
C8233_RS00545	COG1741	Belongs to the pirin family
C8233_RS00555	COG0583	DNA-binding transcription factor activity
C8233_RS00565	COG0156	8-amino-7-oxononanoate synthase activity
C8233_RS00575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C8233_RS00585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C8233_RS00625	COG1881	PFAM PEBP family protein
C8233_RS00650	COG1250	3-hydroxyacyl-CoA dehydrogenase
C8233_RS00650	COG0824	Thioesterase
C8233_RS00660	COG3246	L-lysine catabolic process to acetate
C8233_RS00675	COG1414	Transcriptional regulator
C8233_RS00680	COG1917	Cupin 2, conserved barrel domain protein
C8233_RS00685	COG1028	Short-chain dehydrogenase reductase Sdr
C8233_RS00720	COG1609	Transcriptional regulator
C8233_RS00725	COG2084	Dehydrogenase
C8233_RS00730	COG3395	kinase activity
C8233_RS00735	COG0235	Class ii aldolase
C8233_RS00740	COG3622	Belongs to the hyi family
C8233_RS00745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C8233_RS00750	COG2610	gluconate transmembrane transporter activity
C8233_RS00755	COG3706	GGDEF domain
C8233_RS00760	COG3300	MHYT domain
C8233_RS00760	COG5001	Diguanylate cyclase
C8233_RS00765	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C8233_RS00775	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C8233_RS00780	COG3243	poly(R)-hydroxyalkanoic acid synthase
C8233_RS00795	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C8233_RS00800	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C8233_RS00800	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C8233_RS00810	COG0356	it plays a direct role in the translocation of protons across the membrane
C8233_RS00825	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C8233_RS00840	COG1271	oxidase subunit
C8233_RS00845	COG1294	oxidase, subunit
C8233_RS00850	COG4988	ABC transporter
C8233_RS00855	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C8233_RS00860	COG0656	L-ascorbic acid biosynthetic process
C8233_RS00875	COG2814	Major facilitator Superfamily
C8233_RS00890	COG4251	negative regulation of phosphorylation
C8233_RS00890	COG5001	Diguanylate cyclase
C8233_RS00890	COG2203	Gaf domain
C8233_RS00890	COG3706	GGDEF domain
C8233_RS00895	COG0583	DNA-binding transcription factor activity
C8233_RS00920	COG4221	oxidoreductase activity
C8233_RS00930	COG0583	DNA-binding transcription factor activity
C8233_RS00950	COG3118	belongs to the thioredoxin family
C8233_RS00955	COG0640	Transcriptional regulator
C8233_RS00960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C8233_RS00985	COG3842	ATPase activity
C8233_RS01005	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C8233_RS01025	COG1064	alcohol dehydrogenase
C8233_RS01045	COG0640	Transcriptional regulator
C8233_RS01050	COG4807	Protein conserved in bacteria
C8233_RS01070	COG1230	cation diffusion facilitator family transporter
C8233_RS01075	COG1012	belongs to the aldehyde dehydrogenase family
C8233_RS01080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C8233_RS01095	COG5002	protein histidine kinase activity
C8233_RS01095	COG5001	Diguanylate cyclase
C8233_RS01105	COG1346	cytolysis
C8233_RS01125	COG1028	Short-chain dehydrogenase reductase Sdr
C8233_RS01130	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C8233_RS01135	COG5000	phosphorelay sensor kinase activity
C8233_RS01140	COG0415	Belongs to the DNA photolyase family
C8233_RS01155	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C8233_RS01165	COG0625	glutathione transferase activity
C8233_RS01170	COG0583	DNA-binding transcription factor activity
C8233_RS01195	COG0789	Transcriptional regulator
C8233_RS01200	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C8233_RS01205	COG1970	mechanosensitive ion channel activity
C8233_RS01210	COG0084	hydrolase, TatD family'
C8233_RS01235	COG0556	nucleotide-excision repair
C8233_RS01275	COG3023	N-Acetylmuramoyl-L-alanine amidase
C8233_RS01285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C8233_RS01300	COG3706	GGDEF domain
C8233_RS01340	COG0583	DNA-binding transcription factor activity
C8233_RS01350	COG1473	amidohydrolase
C8233_RS01360	COG2942	2-epimerase
C8233_RS01390	COG1609	Transcriptional regulator
C8233_RS01395	COG2814	Major facilitator Superfamily
C8233_RS01405	COG1252	NADH dehydrogenase
C8233_RS01415	COG1012	belongs to the aldehyde dehydrogenase family
C8233_RS01420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C8233_RS01425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C8233_RS01440	COG3314	Sporulation integral membrane protein YlbJ
C8233_RS01480	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C8233_RS01490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C8233_RS01500	COG0583	DNA-binding transcription factor activity
C8233_RS01505	COG1012	belongs to the aldehyde dehydrogenase family
C8233_RS01525	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C8233_RS01525	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C8233_RS01535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C8233_RS01540	COG2873	o-acetylhomoserine
C8233_RS01570	COG0318	PFAM AMP-dependent synthetase and ligase
C8233_RS01605	COG2211	Major facilitator Superfamily
C8233_RS01625	COG2040	homocysteine
C8233_RS01630	COG0833	amino acid
C8233_RS01635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C8233_RS01645	COG0531	amino acid
C8233_RS01670	COG1028	Short-chain dehydrogenase reductase Sdr
C8233_RS01690	COG0243	molybdopterin cofactor binding
C8233_RS01695	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C8233_RS01710	COG0697	spore germination
C8233_RS01715	COG2207	Transcriptional regulator
C8233_RS01715	COG0662	Cupin 2, conserved barrel domain protein
C8233_RS01735	COG2010	Cytochrome c
C8233_RS01755	COG2814	Major facilitator Superfamily
C8233_RS01760	COG1609	Transcriptional regulator
C8233_RS01765	COG1879	ABC-type sugar transport system periplasmic component
C8233_RS01770	COG1172	Belongs to the binding-protein-dependent transport system permease family
C8233_RS01780	COG1869	D-ribose catabolic process
C8233_RS01785	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C8233_RS01820	COG1360	Flagellar Motor Protein
C8233_RS01825	COG2198	Histidine kinase
C8233_RS01825	COG0643	Histidine kinase
C8233_RS01830	COG0835	chemotaxis
C8233_RS01835	COG0840	transmembrane signaling receptor activity
C8233_RS01840	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C8233_RS01850	COG0745	RESPONSE REGULATOR receiver
C8233_RS01860	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C8233_RS01865	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C8233_RS01895	COG1558	bacterial-type flagellum-dependent cell motility
C8233_RS01900	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C8233_RS01910	COG4787	bacterial-type flagellum-dependent cell motility
C8233_RS01925	COG1706	bacterial-type flagellum-dependent cell motility
C8233_RS01930	COG1705	Flagellar rod assembly protein muramidase FlgJ
C8233_RS01930	COG3951	Flagellar rod assembly protein muramidase FlgJ
C8233_RS01935	COG1256	bacterial-type flagellum assembly
C8233_RS01940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C8233_RS01950	COG1987	bacterial-type flagellum assembly
C8233_RS01970	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C8233_RS01975	COG1580	Controls the rotational direction of flagella during chemotaxis
C8233_RS02000	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C8233_RS02020	COG1191	sigma factor activity
C8233_RS02030	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C8233_RS02040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C8233_RS02050	COG1566	PFAM secretion protein HlyD family protein
C8233_RS02055	COG1289	transmembrane transporter activity
C8233_RS02065	COG2610	gluconate transmembrane transporter activity
C8233_RS02085	COG0800	Aldolase
C8233_RS02090	COG3734	2-keto-3-deoxy-galactonokinase
C8233_RS02095	COG1028	Short-chain dehydrogenase reductase Sdr
C8233_RS02100	COG4948	Mandelate Racemase Muconate Lactonizing
C8233_RS02105	COG2186	Transcriptional regulator
C8233_RS02135	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C8233_RS02150	COG0534	Mate efflux family protein
C8233_RS02160	COG0316	Belongs to the HesB IscA family
C8233_RS02160	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C8233_RS02165	COG3300	MHYT domain
C8233_RS02165	COG5001	Diguanylate cyclase
C8233_RS02170	COG0456	acetyltransferase
C8233_RS02175	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C8233_RS02180	COG1917	Cupin 2, conserved barrel domain protein
C8233_RS02195	COG4067	protein conserved in archaea
C8233_RS02195	COG0189	ligase activity
C8233_RS02215	COG0735	belongs to the Fur family
C8233_RS02220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C8233_RS02230	COG1121	(ABC) transporter
C8233_RS02235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C8233_RS02240	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C8233_RS02245	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C8233_RS02250	COG5642	Protein of unknown function (DUF2384)
C8233_RS02260	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C8233_RS02265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C8233_RS02270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C8233_RS02275	COG1120	ATPase activity
C8233_RS02280	COG2166	iron-sulfur cluster assembly
C8233_RS02295	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C8233_RS02315	COG0288	reversible hydration of carbon dioxide
C8233_RS02320	COG0747	negative chemotaxis
C8233_RS02325	COG0601	transmembrane transport
C8233_RS02330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C8233_RS02335	COG0444	Belongs to the ABC transporter superfamily
C8233_RS02340	COG4608	Belongs to the ABC transporter superfamily
C8233_RS02345	COG0583	DNA-binding transcription factor activity
C8233_RS02350	COG0006	proline dipeptidase activity
C8233_RS02355	COG0429	hydrolase of the alpha beta-hydrolase fold
C8233_RS02370	COG3012	SEC-C Motif Domain Protein
C8233_RS02375	COG2911	Protein conserved in bacteria
C8233_RS02380	COG0729	surface antigen
C8233_RS02405	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C8233_RS02425	COG1028	Short-chain dehydrogenase reductase Sdr
C8233_RS02440	COG0823	Involved in the tonB-independent uptake of proteins
C8233_RS02460	COG0824	Thioesterase
C8233_RS02465	COG2255	four-way junction helicase activity
C8233_RS02470	COG0632	four-way junction helicase activity
C8233_RS02475	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C8233_RS02480	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C8233_RS02490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C8233_RS02500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C8233_RS02510	COG1056	cytidyltransferase-related domain
C8233_RS02510	COG1051	belongs to the nudix hydrolase family
C8233_RS02515	COG0583	DNA-binding transcription factor activity
C8233_RS02520	COG1027	Aspartate ammonia-lyase
C8233_RS02530	COG0515	serine threonine protein kinase
C8233_RS02540	COG0022	dehydrogenase e1 component
C8233_RS02545	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C8233_RS02550	COG1301	dicarboxylic acid transport
C8233_RS02560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C8233_RS02565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C8233_RS02575	COG2840	Smr protein MutS2
C8233_RS02585	COG1177	transmembrane transport
C8233_RS02590	COG1176	ABC-type spermidine putrescine transport system, permease component I
C8233_RS02595	COG3842	ATPase activity
C8233_RS02600	COG1295	ribonuclease BN
C8233_RS02605	COG1393	Belongs to the ArsC family
C8233_RS02630	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C8233_RS02635	COG1687	branched-chain amino acid
C8233_RS02640	COG0259	pyridoxamine-phosphate oxidase activity
C8233_RS02650	COG0564	pseudouridine synthase activity
C8233_RS02665	COG4175	Glycine betaine
C8233_RS02665	COG0517	IMP dehydrogenase activity
C8233_RS02695	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C8233_RS02725	COG3383	formate dehydrogenase (NAD+) activity
C8233_RS02725	COG0243	molybdopterin cofactor binding
C8233_RS02730	COG0437	4 iron, 4 sulfur cluster binding
C8233_RS02745	COG0521	Mo-molybdopterin cofactor biosynthetic process
C8233_RS02750	COG0303	'Molybdopterin
C8233_RS02755	COG3338	carbonate dehydratase activity
C8233_RS02770	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C8233_RS02775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C8233_RS02780	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
C8233_RS02785	COG0709	Synthesizes selenophosphate from selenide and ATP
C8233_RS02815	COG0154	amidase activity
C8233_RS02825	COG0765	amino acid transport
C8233_RS02830	COG0765	amino acid transport
C8233_RS02855	COG1309	transcriptional regulator
C8233_RS02860	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C8233_RS02865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C8233_RS02870	COG3608	succinylglutamate desuccinylase aspartoacylase
C8233_RS02870	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C8233_RS02875	COG0402	S-adenosylhomocysteine deaminase activity
C8233_RS02890	COG2233	PERMEase
C8233_RS02895	COG0737	Belongs to the 5'-nucleotidase family
C8233_RS02900	COG1522	sequence-specific DNA binding
C8233_RS02910	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C8233_RS02935	COG0252	asparaginase activity
C8233_RS02970	COG0446	pyridine nucleotide-disulphide oxidoreductase
C8233_RS02970	COG1902	pentaerythritol trinitrate reductase activity
C8233_RS02990	COG2351	hydroxyisourate hydrolase activity
C8233_RS03005	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C8233_RS03015	COG1192	Involved in chromosome partitioning
C8233_RS03020	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C8233_RS03025	COG1115	amino acid carrier protein
C8233_RS03030	COG1757	Na H antiporter
C8233_RS03040	COG0640	Transcriptional regulator
C8233_RS03045	COG0616	signal peptide processing
C8233_RS03065	COG0328	RNA-DNA hybrid ribonuclease activity
C8233_RS03070	COG2226	methyltransferase
C8233_RS03075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C8233_RS03080	COG1388	LysM domain
C8233_RS03080	COG0741	lytic transglycosylase activity
C8233_RS03085	COG4166	transmembrane transport
C8233_RS03090	COG4174	ABC transporter (Permease)
C8233_RS03095	COG4239	(ABC) transporter, permease
C8233_RS03100	COG4172	Belongs to the ABC transporter superfamily
C8233_RS03125	COG4774	siderophore transport
C8233_RS03130	COG4615	Cyclic peptide transporter
C8233_RS03135	COG0417	DNA replication proofreading
C8233_RS03175	COG3530	Putative quorum-sensing-regulated virulence factor
C8233_RS03190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C8233_RS03195	COG0006	proline dipeptidase activity
C8233_RS03200	COG0583	DNA-binding transcription factor activity
C8233_RS03205	COG0640	Transcriptional regulator
C8233_RS03210	COG1393	Belongs to the ArsC family
C8233_RS03215	COG0431	NADPH-dependent FMN reductase
C8233_RS03225	COG0583	DNA-binding transcription factor activity
C8233_RS03240	COG3437	response regulator, receiver
C8233_RS03240	COG2770	Histidine kinase
C8233_RS03245	COG0583	DNA-binding transcription factor activity
C8233_RS03260	COG0604	alcohol dehydrogenase
C8233_RS03260	COG1028	Short-chain dehydrogenase reductase Sdr
C8233_RS03260	COG3321	synthase
C8233_RS03265	COG0625	glutathione transferase activity
C8233_RS03270	COG1971	Probably functions as a manganese efflux pump
C8233_RS03290	COG1757	Na H antiporter
C8233_RS03300	COG5006	permease, DMT superfamily
C8233_RS03310	COG4172	Belongs to the ABC transporter superfamily
C8233_RS03315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C8233_RS03350	COG2807	transmembrane transport
C8233_RS03355	COG2207	Transcriptional regulator
C8233_RS03360	COG1794	racemase activity, acting on amino acids and derivatives
C8233_RS03365	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C8233_RS03365	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C8233_RS03375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C8233_RS03380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C8233_RS03385	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C8233_RS03390	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C8233_RS03395	COG0583	DNA-binding transcription factor activity
C8233_RS03415	COG0235	Class ii aldolase
C8233_RS03420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C8233_RS03425	COG0697	spore germination
C8233_RS03430	COG1902	pentaerythritol trinitrate reductase activity
C8233_RS03480	COG1252	NADH dehydrogenase
C8233_RS03485	COG1802	Transcriptional regulator
C8233_RS03495	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C8233_RS03500	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C8233_RS03510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C8233_RS03520	COG0583	DNA-binding transcription factor activity
C8233_RS03535	COG4336	lyase activity
C8233_RS03550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C8233_RS03580	COG0604	alcohol dehydrogenase
C8233_RS03610	COG0583	DNA-binding transcription factor activity
C8233_RS03625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C8233_RS03640	COG0446	pyridine nucleotide-disulphide oxidoreductase
C8233_RS03640	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C8233_RS03655	COG0004	ammonium transporteR
C8233_RS03665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C8233_RS03675	COG0069	glutamate synthase activity
C8233_RS03680	COG2218	PFAM glutamate synthase alpha subunit domain protein
C8233_RS03685	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C8233_RS03695	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C8233_RS03710	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C8233_RS03720	COG1609	Transcriptional regulator
C8233_RS03740	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C8233_RS03760	COG0583	DNA-binding transcription factor activity
C8233_RS03765	COG0667	Aldo Keto reductase
C8233_RS03770	COG2249	NAD(P)H dehydrogenase (quinone) activity
C8233_RS03790	COG1999	signal sequence binding
C8233_RS03835	COG4964	Belongs to the GSP D family
C8233_RS03855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C8233_RS03875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C8233_RS03900	COG0583	DNA-binding transcription factor activity
C8233_RS03905	COG2828	Protein conserved in bacteria
C8233_RS03925	COG1253	flavin adenine dinucleotide binding
C8233_RS03930	COG1024	Enoyl-CoA hydratase
C8233_RS03945	COG0583	DNA-binding transcription factor activity
C8233_RS03950	COG0446	pyridine nucleotide-disulphide oxidoreductase
C8233_RS03950	COG1902	pentaerythritol trinitrate reductase activity
C8233_RS03955	COG3036	rescue of stalled ribosome
C8233_RS03965	COG0546	phosphoglycolate phosphatase activity
C8233_RS03970	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C8233_RS03975	COG0004	ammonium transporteR
C8233_RS03980	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C8233_RS03985	COG3850	Histidine kinase
C8233_RS03990	COG2197	response regulator
C8233_RS04005	COG2076	Multidrug Resistance protein
C8233_RS04010	COG2076	Multidrug Resistance protein
C8233_RS04025	COG0583	DNA-binding transcription factor activity
C8233_RS04040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C8233_RS04060	COG1116	anion transmembrane transporter activity
C8233_RS04060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C8233_RS04075	COG0439	Biotin carboxylase
C8233_RS04110	COG1944	ATP diphosphatase activity
C8233_RS04130	COG1028	Short-chain dehydrogenase reductase Sdr
C8233_RS04140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C8233_RS04145	COG1653	transport
C8233_RS04155	COG4221	oxidoreductase activity
C8233_RS04160	COG3321	synthase
C8233_RS04160	COG0604	alcohol dehydrogenase
C8233_RS04165	COG0583	DNA-binding transcription factor activity
C8233_RS04175	COG2175	clavaminate synthase activity
C8233_RS04200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C8233_RS04240	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C8233_RS04250	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C8233_RS04255	COG1396	sequence-specific DNA binding
C8233_RS04290	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C8233_RS04295	COG0395	ABC-type sugar transport system, permease component
C8233_RS04300	COG3842	ATPase activity
C8233_RS04305	COG1840	ABC-type Fe3 transport system, periplasmic component
C8233_RS04450	COG1012	belongs to the aldehyde dehydrogenase family
C8233_RS04455	COG4948	Mandelate Racemase Muconate Lactonizing
C8233_RS04475	COG2084	Dehydrogenase
C8233_RS04480	COG0583	DNA-binding transcription factor activity
C8233_RS04485	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C8233_RS04500	COG3718	enzyme involved in inositol metabolism
C8233_RS04505	COG0673	inositol 2-dehydrogenase activity
C8233_RS04510	COG1737	Transcriptional regulator
C8233_RS04520	COG1172	Belongs to the binding-protein-dependent transport system permease family
C8233_RS04530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C8233_RS04535	COG3962	Belongs to the TPP enzyme family
C8233_RS04550	COG1082	Xylose isomerase domain protein TIM barrel
C8233_RS04555	COG2814	Major facilitator Superfamily
C8233_RS04555	COG0477	Major facilitator Superfamily
C8233_RS04565	COG0477	Major facilitator Superfamily
C8233_RS04565	COG2814	Major facilitator Superfamily
C8233_RS04570	COG1082	Xylose isomerase domain protein TIM barrel
C8233_RS04575	COG0673	inositol 2-dehydrogenase activity
C8233_RS04580	COG3962	Belongs to the TPP enzyme family
C8233_RS04585	COG1028	Short-chain dehydrogenase reductase Sdr
C8233_RS04605	COG0673	inositol 2-dehydrogenase activity
C8233_RS04625	COG1653	transport
C8233_RS04640	COG0366	Alpha amylase catalytic
C8233_RS04645	COG3842	ATPase activity
C8233_RS04650	COG0366	Alpha amylase catalytic
C8233_RS04655	COG0366	Alpha amylase catalytic
C8233_RS04660	COG1653	transport
C8233_RS04665	COG0366	Alpha amylase catalytic
C8233_RS04670	COG1609	Transcriptional regulator
C8233_RS04680	COG0129	dihydroxy-acid dehydratase activity
C8233_RS04700	COG3386	PFAM SMP-30 Gluconolaconase
C8233_RS04715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C8233_RS04725	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C8233_RS04730	COG0277	FAD linked oxidase domain protein
C8233_RS04785	COG2086	electron transfer activity
C8233_RS04805	COG4607	ABC-type enterochelin transport system periplasmic component
C8233_RS04810	COG4771	TonB-dependent receptor
C8233_RS04815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C8233_RS04855	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C8233_RS04920	COG0583	DNA-binding transcription factor activity
C8233_RS04930	COG1301	dicarboxylic acid transport
C8233_RS04940	COG1187	pseudouridine synthase activity
C8233_RS04960	COG1295	ribonuclease BN
C8233_RS04965	COG1764	response to oxidative stress
C8233_RS05000	COG0463	Glycosyl transferase, family 2
C8233_RS05020	COG4067	protein conserved in archaea
C8233_RS05020	COG0189	ligase activity
C8233_RS05030	COG0217	transcriptional regulatory protein
C8233_RS05035	COG2920	part of a sulfur-relay system
C8233_RS05050	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C8233_RS05070	COG0513	Belongs to the DEAD box helicase family
C8233_RS05080	COG3263	regulation of cellular component size
C8233_RS05090	COG1116	anion transmembrane transporter activity
C8233_RS05095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C8233_RS05100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C8233_RS05110	COG0596	Alpha beta hydrolase
C8233_RS05115	COG0583	DNA-binding transcription factor activity
C8233_RS05120	COG2855	membrane
C8233_RS05145	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C8233_RS05150	COG0204	Acyl-transferase
C8233_RS05175	COG0583	DNA-binding transcription factor activity
C8233_RS05180	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C8233_RS05185	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C8233_RS05190	COG1278	Cold shock
C8233_RS05195	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C8233_RS05200	COG1115	amino acid carrier protein
C8233_RS05205	COG0509	glycine decarboxylation via glycine cleavage system
C8233_RS05210	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C8233_RS05210	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C8233_RS05230	COG0395	ABC-type sugar transport system, permease component
C8233_RS05240	COG3842	ATPase activity
C8233_RS05250	COG3284	Transcriptional regulator
C8233_RS05260	COG1176	ABC-type spermidine putrescine transport system, permease component I
C8233_RS05270	COG3842	ATPase activity
C8233_RS05285	COG0678	peroxiredoxin activity
C8233_RS05285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C8233_RS05295	COG0517	IMP dehydrogenase activity
C8233_RS05295	COG0617	tRNA 3'-terminal CCA addition
C8233_RS05295	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C8233_RS05300	COG3048	D-serine ammonia-lyase activity
C8233_RS05310	COG2186	Transcriptional regulator
C8233_RS05315	COG0277	FAD linked oxidase domain protein
C8233_RS05320	COG0277	FAD linked oxidase domain protein
C8233_RS05325	COG0247	lactate metabolic process
C8233_RS05330	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C8233_RS05340	COG0667	Aldo Keto reductase
C8233_RS05345	COG1070	Carbohydrate kinase
C8233_RS05360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C8233_RS05365	COG3842	ATPase activity
C8233_RS05375	COG1175	transmembrane transport
C8233_RS05380	COG1653	transport
C8233_RS05410	COG1280	lysine exporter protein (LysE YggA)
C8233_RS05425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C8233_RS05455	COG1414	Transcriptional regulator
C8233_RS05485	COG0668	transmembrane transport
C8233_RS05505	COG0463	Glycosyl transferase, family 2
C8233_RS05515	COG4890	Cyd operon protein YbgT
C8233_RS05520	COG1294	oxidase, subunit
C8233_RS05540	COG3047	cAMP biosynthetic process
C8233_RS05550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C8233_RS05565	COG0400	carboxylic ester hydrolase activity
C8233_RS05635	COG1126	abc transporter atp-binding protein
C8233_RS05660	COG0189	ligase activity
C8233_RS05690	COG0719	Fe-S assembly protein
C8233_RS05695	COG0396	ATPase activity
C8233_RS05700	COG0719	Fe-S assembly protein
C8233_RS05705	COG1959	2 iron, 2 sulfur cluster binding
C8233_RS05710	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C8233_RS05715	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C8233_RS05720	COG0330	HflC and HflK could
C8233_RS05725	COG0330	HflC and HflK could
C8233_RS05730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C8233_RS05735	COG1923	regulation of RNA biosynthetic process
C8233_RS05740	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C8233_RS05755	COG0860	N-Acetylmuramoyl-L-alanine amidase
C8233_RS05760	COG0802	atpase or kinase
C8233_RS05765	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C8233_RS05765	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C8233_RS05775	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C8233_RS05780	COG1162	GTPase activity
C8233_RS05785	COG2252	PERMEase
C8233_RS05795	COG0688	phosphatidylethanolamine metabolic process
C8233_RS05800	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C8233_RS05805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C8233_RS05825	COG3830	Belongs to the UPF0237 family
C8233_RS05825	COG0560	Phosphoserine phosphatase
C8233_RS05840	COG3150	esterase
C8233_RS05845	COG0166	Belongs to the GPI family
C8233_RS05850	COG4106	trans-aconitate 2-methyltransferase activity
C8233_RS05860	COG3604	Transcriptional regulator
C8233_RS05865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C8233_RS05865	COG1017	nitric oxide dioxygenase activity
C8233_RS05870	COG2895	sulfate adenylyltransferase (ATP) activity
C8233_RS05875	COG0175	sulfate reduction
C8233_RS05880	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C8233_RS05885	COG3151	Protein conserved in bacteria
C8233_RS05890	COG0494	nUDIX hydrolase
C8233_RS05900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C8233_RS05905	COG2813	Specifically methylates the guanine in position
C8233_RS05910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C8233_RS05915	COG0438	transferase activity, transferring glycosyl groups
C8233_RS05935	COG0159	tryptophan synthase activity
C8233_RS05940	COG0133	tryptophan synthase activity
C8233_RS05960	COG1280	lysine exporter protein (LysE YggA)
C8233_RS05965	COG2353	YceI-like domain
C8233_RS05970	COG3038	cytochrome b561
C8233_RS05995	COG0285	dihydrofolate synthase activity
C8233_RS06000	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C8233_RS06005	COG0135	phosphoribosylanthranilate isomerase activity
C8233_RS06025	COG0473	3-isopropylmalate dehydrogenase activity
C8233_RS06030	COG0066	3-isopropylmalate dehydratase activity
C8233_RS06035	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C8233_RS06045	COG3243	poly(R)-hydroxyalkanoic acid synthase
C8233_RS06060	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C8233_RS06085	COG0596	Alpha beta hydrolase
C8233_RS06120	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C8233_RS06130	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C8233_RS06140	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C8233_RS06160	COG0326	Molecular chaperone. Has ATPase activity
C8233_RS06180	COG3339	Conserved Protein
C8233_RS06185	COG0741	lytic transglycosylase activity
C8233_RS06230	COG1278	Cold shock
C8233_RS06245	COG0330	HflC and HflK could
C8233_RS06255	COG1597	lipid kinase activity
C8233_RS06260	COG2814	Major facilitator Superfamily
C8233_RS06300	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C8233_RS06315	COG1966	Carbon starvation protein
C8233_RS06325	COG0003	Pfam Anion-transporting ATPase
C8233_RS06330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C8233_RS06335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C8233_RS06340	COG2995	paraquat-inducible protein a
C8233_RS06345	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C8233_RS06345	COG3008	intermembrane lipid transfer
C8233_RS06355	COG3134	Outer membrane lipoprotein
C8233_RS06385	COG2807	transmembrane transport
C8233_RS06405	COG0252	asparaginase activity
C8233_RS06410	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C8233_RS06415	COG3956	TIGRFAM MazG family protein
C8233_RS06420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C8233_RS06425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C8233_RS06435	COG0784	Response regulator, receiver
C8233_RS06435	COG2205	protein histidine kinase activity
C8233_RS06435	COG5002	protein histidine kinase activity
C8233_RS06450	COG1381	Involved in DNA repair and RecF pathway recombination
C8233_RS06455	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C8233_RS06460	COG0571	ribonuclease III activity
C8233_RS06465	COG0681	Belongs to the peptidase S26 family
C8233_RS06470	COG0481	GTPase activity
C8233_RS06475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C8233_RS06485	COG4628	conserved protein (DUF2132)
C8233_RS06500	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C8233_RS06505	COG1199	ATP-dependent helicase activity
C8233_RS06520	COG0708	Exodeoxyribonuclease III
C8233_RS06535	COG0848	biopolymer transport protein
C8233_RS06570	COG1301	dicarboxylic acid transport
C8233_RS06590	COG0084	hydrolase, TatD family'
C8233_RS06605	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C8233_RS06610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C8233_RS06615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C8233_RS06620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C8233_RS06625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C8233_RS06635	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C8233_RS06640	COG0416	fatty acid biosynthetic process
C8233_RS06645	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C8233_RS06650	COG1399	metal-binding, possibly nucleic acid-binding protein
C8233_RS06655	COG0424	maF-like protein
C8233_RS06660	COG0616	signal peptide processing
C8233_RS06660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C8233_RS06665	COG0546	phosphoglycolate phosphatase activity
C8233_RS06675	COG1530	ribonuclease E activity
C8233_RS06680	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C8233_RS06690	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C8233_RS06695	COG2835	tetraacyldisaccharide 4'-kinase activity
C8233_RS06700	COG1663	tetraacyldisaccharide 4'-kinase activity
C8233_RS06705	COG1132	(ABC) transporter
C8233_RS06710	COG0848	biopolymer transport protein
C8233_RS06715	COG0811	peptide transport
C8233_RS06730	COG1136	(ABC) transporter
C8233_RS06735	COG4591	ABC-type transport system involved in lipoprotein release permease component
C8233_RS06740	COG2957	Belongs to the agmatine deiminase family
C8233_RS06745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C8233_RS06760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C8233_RS06770	COG1477	protein flavinylation
C8233_RS06775	COG2871	sodium ion transport
C8233_RS06780	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C8233_RS06795	COG1805	sodium ion transport
C8233_RS06800	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C8233_RS06810	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C8233_RS06820	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C8233_RS06825	COG0668	transmembrane transport
C8233_RS06830	COG1472	Belongs to the glycosyl hydrolase 3 family
C8233_RS06835	COG1376	ErfK ybiS ycfS ynhG family protein
C8233_RS06840	COG1309	transcriptional regulator
C8233_RS06845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C8233_RS06865	COG0469	pyruvate kinase activity
C8233_RS06870	COG1803	Methylglyoxal synthase
C8233_RS06885	COG1028	Short-chain dehydrogenase reductase Sdr
C8233_RS06895	COG5016	pyruvate
C8233_RS06895	COG0511	ligase activity, forming carbon-carbon bonds
C8233_RS06900	COG0439	Biotin carboxylase
C8233_RS06910	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C8233_RS06915	COG0321	lipoyl(octanoyl) transferase activity
C8233_RS06920	COG2921	Belongs to the UPF0250 family
C8233_RS06925	COG1686	Belongs to the peptidase S11 family
C8233_RS06930	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C8233_RS06935	COG2951	lytic endotransglycosylase activity
C8233_RS06940	COG0772	Belongs to the SEDS family
C8233_RS06945	COG0768	penicillin binding
C8233_RS06950	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C8233_RS06960	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C8233_RS06965	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C8233_RS06980	COG0586	Pfam SNARE associated Golgi protein
C8233_RS07000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C8233_RS07005	COG0205	6-phosphofructokinase activity
C8233_RS07010	COG0702	epimerase
C8233_RS07035	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C8233_RS07040	COG0511	ligase activity, forming carbon-carbon bonds
C8233_RS07050	COG2264	protein methyltransferase activity
C8233_RS07065	COG0138	bifunctional purine biosynthesis protein purh
C8233_RS07080	COG2066	Belongs to the glutaminase family
C8233_RS07100	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C8233_RS07105	COG0302	gtp cyclohydrolase
C8233_RS07110	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C8233_RS07120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C8233_RS07125	COG0156	8-amino-7-oxononanoate synthase activity
C8233_RS07130	COG0596	Alpha beta hydrolase
C8233_RS07135	COG1073	alpha beta
C8233_RS07135	COG2226	methyltransferase
C8233_RS07140	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C8233_RS07155	COG1742	UPF0060 membrane protein
C8233_RS07160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C8233_RS07170	COG1960	acyl-CoA dehydrogenase activity
C8233_RS07175	COG1648	precorrin-2 dehydrogenase activity
C8233_RS07175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C8233_RS07180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C8233_RS07185	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C8233_RS07195	COG0277	FAD linked oxidase domain protein
C8233_RS07195	COG0247	lactate metabolic process
C8233_RS07205	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C8233_RS07210	COG4206	TonB-dependent receptor
C8233_RS07215	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C8233_RS07220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C8233_RS07230	COG0284	orotidine-5'-phosphate decarboxylase activity
C8233_RS07240	COG1047	Peptidyl-prolyl cis-trans
C8233_RS07250	COG2814	Major facilitator Superfamily
C8233_RS07275	COG2244	polysaccharide biosynthetic process
C8233_RS07280	COG1215	transferase activity, transferring glycosyl groups
C8233_RS07295	COG0653	protein targeting
C8233_RS07300	COG2040	homocysteine
C8233_RS07310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C8233_RS07335	COG1737	Transcriptional regulator
C8233_RS07340	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C8233_RS07345	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C8233_RS07345	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C8233_RS07395	COG0352	thiamine-phosphate diphosphorylase activity
C8233_RS07400	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C8233_RS07405	COG0653	protein targeting
C8233_RS07420	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C8233_RS07440	COG1181	Belongs to the D-alanine--D-alanine ligase family
C8233_RS07445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C8233_RS07450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C8233_RS07455	COG0772	Belongs to the SEDS family
C8233_RS07460	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C8233_RS07465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C8233_RS07470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C8233_RS07475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C8233_RS07510	COG0792	nuclease activity
C8233_RS07515	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C8233_RS07520	COG2823	Periplasmic or secreted lipoprotein
C8233_RS07525	COG2969	positive regulation of protein catabolic process
C8233_RS07530	COG0625	glutathione transferase activity
C8233_RS07540	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C8233_RS07550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C8233_RS07555	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C8233_RS07560	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C8233_RS07575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C8233_RS07580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C8233_RS07585	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C8233_RS07590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C8233_RS07595	COG5007	Belongs to the BolA IbaG family
C8233_RS07610	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C8233_RS07615	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C8233_RS07620	COG1127	ABC transporter
C8233_RS07635	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C8233_RS07645	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C8233_RS07650	COG1137	ATPase activity
C8233_RS07655	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C8233_RS07670	COG1660	Displays ATPase and GTPase activities
C8233_RS07675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C8233_RS07680	COG2239	Acts as a magnesium transporter
C8233_RS07685	COG0312	modulator of DNA gyrase
C8233_RS07690	COG3028	Belongs to the UPF0307 family
C8233_RS07695	COG0312	modulator of DNA gyrase
C8233_RS07705	COG1530	ribonuclease E activity
C8233_RS07710	COG0424	maF-like protein
C8233_RS07715	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C8233_RS07720	COG1792	Involved in formation and maintenance of cell shape
C8233_RS07725	COG1077	Cell shape determining protein MreB Mrl
C8233_RS07730	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C8233_RS07735	COG0154	amidase activity
C8233_RS07740	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C8233_RS07750	COG1012	belongs to the aldehyde dehydrogenase family
C8233_RS07760	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C8233_RS07765	COG0174	glutamine synthetase
C8233_RS07770	COG1757	Na H antiporter
C8233_RS07775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C8233_RS07795	COG1177	transmembrane transport
C8233_RS07800	COG1176	ABC-type spermidine putrescine transport system, permease component I
C8233_RS07805	COG3842	ATPase activity
C8233_RS07810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C8233_RS07815	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C8233_RS07825	COG2890	protein-(glutamine-N5) methyltransferase activity
C8233_RS07830	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C8233_RS07835	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C8233_RS07845	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C8233_RS07865	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C8233_RS07870	COG0193	aminoacyl-tRNA hydrolase activity
C8233_RS07880	COG0583	DNA-binding transcription factor activity
C8233_RS07895	COG1362	aminopeptidase activity
C8233_RS07930	COG1309	transcriptional regulator
C8233_RS07940	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C8233_RS07970	COG0395	ABC-type sugar transport system, permease component
C8233_RS07975	COG3842	ATPase activity
C8233_RS07985	COG1349	DNA-binding transcription factor activity
C8233_RS07995	COG0134	indole-3-glycerol-phosphate synthase activity
C8233_RS08000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C8233_RS08015	COG0546	phosphoglycolate phosphatase activity
C8233_RS08020	COG1252	NADH dehydrogenase
C8233_RS08025	COG2827	Endonuclease containing a URI domain
C8233_RS08030	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C8233_RS08035	COG0405	Gamma-glutamyltransferase
C8233_RS08050	COG0500	methyltransferase
C8233_RS08055	COG4991	sh3 domain protein
C8233_RS08060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C8233_RS08065	COG1702	phosphate starvation-inducible protein PhoH
C8233_RS08070	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C8233_RS08075	COG4535	Mg2 and Co2 transporter CorC
C8233_RS08100	COG0495	leucyl-tRNA aminoacylation
C8233_RS08110	COG1466	dna polymerase III delta subunit
C8233_RS08125	COG0183	Belongs to the thiolase family
C8233_RS08130	COG1024	Enoyl-CoA hydratase
C8233_RS08130	COG1250	3-hydroxyacyl-CoA dehydrogenase
C8233_RS08150	COG0589	response to stress
C8233_RS08155	COG0488	(ABC) transporter
C8233_RS08170	COG0513	Belongs to the DEAD box helicase family
C8233_RS08180	COG4208	sulfate ABC transporter
C8233_RS08185	COG1840	ABC-type Fe3 transport system, periplasmic component
C8233_RS08190	COG3101	peptidyl-lysine hydroxylation
C8233_RS08215	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C8233_RS08245	COG0501	Belongs to the peptidase M48B family
C8233_RS08250	COG1704	LemA family
C8233_RS08255	COG2079	MmgE PrpD family protein
C8233_RS08260	COG2828	Protein conserved in bacteria
C8233_RS08265	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C8233_RS08270	COG0372	Belongs to the citrate synthase family
C8233_RS08275	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C8233_RS08280	COG1802	Transcriptional regulator
C8233_RS08295	COG0175	sulfate reduction
C8233_RS08300	COG0583	DNA-binding transcription factor activity
C8233_RS08305	COG0730	response to heat
C8233_RS08310	COG3118	belongs to the thioredoxin family
C8233_RS08315	COG0628	permease
C8233_RS08320	COG1960	acyl-CoA dehydrogenase activity
C8233_RS08330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C8233_RS08335	COG1309	transcriptional regulator
C8233_RS08340	COG0183	Belongs to the thiolase family
C8233_RS08345	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C8233_RS08350	COG0573	inorganic phosphate transmembrane transporter activity
C8233_RS08355	COG0573	inorganic phosphate transmembrane transporter activity
C8233_RS08365	COG2814	Major facilitator Superfamily
C8233_RS08385	COG2853	Lipoprotein
C8233_RS08395	COG1643	Atp-dependent helicase
C8233_RS08400	COG0318	PFAM AMP-dependent synthetase and ligase
C8233_RS08410	COG0121	glutamine amidotransferase
C8233_RS08460	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C8233_RS08470	COG2814	Major facilitator Superfamily
C8233_RS08475	COG3106	COG3106 Predicted ATPase
C8233_RS08480	COG3768	UPF0283 membrane protein
C8233_RS08485	COG0673	inositol 2-dehydrogenase activity
C8233_RS08495	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C8233_RS08505	COG0438	transferase activity, transferring glycosyl groups
C8233_RS08520	COG0584	glycerophosphoryl diester phosphodiesterase
C8233_RS08535	COG0045	succinate-CoA ligase (ADP-forming) activity
C8233_RS08560	COG1053	succinate dehydrogenase
C8233_RS08565	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C8233_RS08580	COG2084	Dehydrogenase
C8233_RS08595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C8233_RS08600	COG4988	ABC transporter
C8233_RS08605	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C8233_RS08615	COG0583	DNA-binding transcription factor activity
C8233_RS08630	COG1309	transcriptional regulator
C8233_RS08640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C8233_RS08645	COG3104	oligopeptide transport
C8233_RS08670	COG3871	stress protein (general stress protein 26)
C8233_RS08690	COG1914	H( )-stimulated, divalent metal cation uptake system
C8233_RS08695	COG2205	protein histidine kinase activity
C8233_RS08705	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C8233_RS08710	COG1074	ATP-dependent DNA helicase activity
C8233_RS08715	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C8233_RS08730	COG0420	3'-5' exonuclease activity
C8233_RS08740	COG1515	deoxyribonuclease V activity
C8233_RS08760	COG0435	Glutathione S-transferase
C8233_RS08765	COG0583	DNA-binding transcription factor activity
C8233_RS08770	COG0739	heme binding
C8233_RS08810	COG0076	glutamate decarboxylase activity
C8233_RS08815	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C8233_RS08820	COG4264	IucA IucC family
C8233_RS08830	COG1120	ATPase activity
C8233_RS08870	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C8233_RS08880	COG1757	Na H antiporter
C8233_RS08885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C8233_RS08885	COG1017	nitric oxide dioxygenase activity
C8233_RS08895	COG0109	protoheme IX farnesyltransferase activity
C8233_RS08900	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C8233_RS08905	COG1845	cytochrome c oxidase, subunit III
C8233_RS08910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C8233_RS08915	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C8233_RS08920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C8233_RS08925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C8233_RS08935	COG3383	formate dehydrogenase (NAD+) activity
C8233_RS08945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C8233_RS08965	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C8233_RS08970	COG2181	nitrate reductase activity
C8233_RS08970	COG0247	lactate metabolic process
C8233_RS08975	COG1902	pentaerythritol trinitrate reductase activity
C8233_RS08975	COG0446	pyridine nucleotide-disulphide oxidoreductase
C8233_RS08990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C8233_RS09010	COG0583	DNA-binding transcription factor activity
C8233_RS09015	COG1953	Uracil, thiamine, allantoin
C8233_RS09040	COG1309	transcriptional regulator
C8233_RS09045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C8233_RS09045	COG1116	anion transmembrane transporter activity
C8233_RS09050	COG0745	RESPONSE REGULATOR receiver
C8233_RS09060	COG2223	nitrite transmembrane transporter activity
C8233_RS09070	COG0513	Belongs to the DEAD box helicase family
C8233_RS09110	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C8233_RS09115	COG0210	DNA helicase
C8233_RS09125	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C8233_RS09125	COG0519	Catalyzes the synthesis of GMP from XMP
C8233_RS09140	COG0642	Histidine kinase
C8233_RS09145	COG0745	RESPONSE REGULATOR receiver
C8233_RS09170	COG2204	response regulator
C8233_RS09180	COG2205	protein histidine kinase activity
C8233_RS09185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C8233_RS09185	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C8233_RS09190	COG0306	phosphate transporter
C8233_RS09195	COG1392	Phosphate transport regulator
C8233_RS09205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C8233_RS09215	COG0009	L-threonylcarbamoyladenylate synthase
C8233_RS09220	COG0613	PHP domain protein
C8233_RS09225	COG2917	probably involved in intracellular septation
C8233_RS09230	COG2350	Protein conserved in bacteria
C8233_RS09235	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C8233_RS09235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C8233_RS09240	COG4565	transcriptional regulatory protein
C8233_RS09245	COG3290	protein histidine kinase activity
C8233_RS09265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C8233_RS09270	COG3115	cell septum assembly
C8233_RS09290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C8233_RS09295	COG1138	Cytochrome C-type biogenesis protein
C8233_RS09300	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C8233_RS09330	COG1739	Uncharacterized protein family UPF0029
C8233_RS09345	COG0583	DNA-binding transcription factor activity
C8233_RS09350	COG1278	Cold shock
C8233_RS09360	COG2205	protein histidine kinase activity
C8233_RS09365	COG0745	RESPONSE REGULATOR receiver
C8233_RS09370	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C8233_RS09370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C8233_RS09375	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C8233_RS09380	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C8233_RS09395	COG0666	response to abiotic stimulus
C8233_RS09400	COG0642	Histidine kinase
C8233_RS09400	COG3850	Histidine kinase
C8233_RS09425	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C8233_RS09430	COG0537	adenosine 5'-monophosphoramidase activity
C8233_RS09440	COG3954	Phosphoribulokinase
C8233_RS09450	COG0151	Belongs to the GarS family
C8233_RS09465	COG0415	Belongs to the DNA photolyase family
C8233_RS09475	COG2111	Na H antiporter
C8233_RS09475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C8233_RS09480	COG1006	Multisubunit Na H antiporter MnhC subunit
C8233_RS09485	COG0651	ATP synthesis coupled electron transport
C8233_RS09490	COG1863	multisubunit Na H antiporter MnhE subunit
C8233_RS09495	COG2212	antiporter activity
C8233_RS09500	COG1320	monovalent cation:proton antiporter activity
C8233_RS09505	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C8233_RS09510	COG3046	protein related to deoxyribodipyrimidine photolyase
C8233_RS09525	COG2199	diguanylate cyclase activity
C8233_RS09525	COG2203	Gaf domain
C8233_RS09525	COG2200	EAL domain
C8233_RS09535	COG0305	Participates in initiation and elongation during chromosome replication
C8233_RS09540	COG0359	binds to the 23S rRNA
C8233_RS09550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C8233_RS09555	COG0360	Binds together with S18 to 16S ribosomal RNA
C8233_RS09560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C8233_RS09565	COG0557	exoribonuclease II activity
C8233_RS09600	COG2719	SpoVR family
C8233_RS09605	COG2718	Belongs to the UPF0229 family
C8233_RS09610	COG2766	serine protein kinase
C8233_RS09625	COG1902	pentaerythritol trinitrate reductase activity
C8233_RS09625	COG0446	pyridine nucleotide-disulphide oxidoreductase
C8233_RS09660	COG3278	Belongs to the heme-copper respiratory oxidase family
C8233_RS09675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C8233_RS09690	COG3220	belongs to the UPF0276 family
C8233_RS09705	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C8233_RS09745	COG0795	lipopolysaccharide-transporting ATPase activity
C8233_RS09750	COG0795	lipopolysaccharide-transporting ATPase activity
C8233_RS09760	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C8233_RS09765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C8233_RS09780	COG0525	valine-tRNA ligase activity
C8233_RS09790	COG0671	phosphoesterase, PA-phosphatase related
C8233_RS09795	COG3706	GGDEF domain
C8233_RS09800	COG0346	lactoylglutathione lyase activity
C8233_RS09805	COG0243	molybdopterin cofactor binding
C8233_RS09810	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C8233_RS09815	COG1054	Belongs to the UPF0176 family
C8233_RS09885	COG4191	Histidine kinase
C8233_RS09900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C8233_RS09905	COG0783	Belongs to the Dps family
C8233_RS09915	COG2259	Doxx family
C8233_RS09925	COG3220	belongs to the UPF0276 family
C8233_RS09940	COG0693	protein deglycase activity
C8233_RS09950	COG2195	Cleaves the N-terminal amino acid of tripeptides
C8233_RS09955	COG1444	tRNA N-acetyltransferase activity
C8233_RS09960	COG1444	tRNA N-acetyltransferase activity
C8233_RS10030	COG2175	clavaminate synthase activity
C8233_RS10040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C8233_RS10050	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C8233_RS10055	COG2204	response regulator
C8233_RS10075	COG1166	arginine decarboxylase activity
C8233_RS10080	COG0179	Fumarylacetoacetate (FAA) hydrolase
C8233_RS10085	COG5285	phytanoyl-CoA dioxygenase
C8233_RS10090	COG1462	curli production assembly transport component CsgG
C8233_RS10105	COG2204	response regulator
C8233_RS10135	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C8233_RS10140	COG1194	a g-specific adenine glycosylase
C8233_RS10155	COG0131	Imidazoleglycerol-phosphate dehydratase
C8233_RS10160	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C8233_RS10165	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C8233_RS10170	COG0107	imidazoleglycerol-phosphate synthase activity
C8233_RS10180	COG3068	Protein conserved in bacteria
C8233_RS10195	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C8233_RS10220	COG1902	pentaerythritol trinitrate reductase activity
C8233_RS10225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C8233_RS10230	COG0346	lactoylglutathione lyase activity
C8233_RS10250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C8233_RS10255	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C8233_RS10285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C8233_RS10290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C8233_RS10290	COG2813	Specifically methylates the guanine in position
C8233_RS10295	COG1607	acyl-coa hydrolase
C8233_RS10310	COG1489	DNA binding
C8233_RS10315	COG0436	Aminotransferase
C8233_RS10320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C8233_RS10325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C8233_RS10340	COG0617	tRNA 3'-terminal CCA addition
C8233_RS10350	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C8233_RS10355	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C8233_RS10360	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C8233_RS10370	COG1185	polyribonucleotide nucleotidyltransferase activity
C8233_RS10375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C8233_RS10380	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C8233_RS10385	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C8233_RS10390	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C8233_RS10395	COG0195	Participates in both transcription termination and antitermination
C8233_RS10400	COG0779	Required for maturation of 30S ribosomal subunits
C8233_RS10415	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C8233_RS10420	COG0149	triose-phosphate isomerase activity
C8233_RS10425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C8233_RS10430	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C8233_RS10435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C8233_RS10440	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C8233_RS10470	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C8233_RS10480	COG0484	heat shock protein binding
C8233_RS10485	COG0443	Heat shock 70 kDa protein
C8233_RS10490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C8233_RS10495	COG0497	DNA recombination
C8233_RS10505	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C8233_RS10510	COG2914	Belongs to the UPF0125 (RnfH) family
C8233_RS10515	COG2867	negative regulation of translational initiation
C8233_RS10520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C8233_RS10530	COG1120	ATPase activity
C8233_RS10535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C8233_RS10540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C8233_RS10545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C8233_RS10550	COG0668	transmembrane transport
C8233_RS10565	COG2959	enzyme of heme biosynthesis
C8233_RS10580	COG0165	Argininosuccinate lyase
C8233_RS10590	COG0019	diaminopimelate decarboxylase activity
C8233_RS10595	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C8233_RS10605	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C8233_RS10610	COG1011	Hydrolase
C8233_RS10620	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C8233_RS10645	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C8233_RS10650	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C8233_RS10655	COG1490	D-aminoacyl-tRNA deacylase activity
C8233_RS10660	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C8233_RS10665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C8233_RS10670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C8233_RS10685	COG1238	metal cluster binding
C8233_RS10690	COG3321	synthase
C8233_RS10690	COG0604	alcohol dehydrogenase
C8233_RS10700	COG0488	(ABC) transporter
C8233_RS10710	COG0545	Peptidyl-prolyl cis-trans isomerase
C8233_RS10715	COG1999	signal sequence binding
C8233_RS10730	COG2226	methyltransferase
C8233_RS10735	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C8233_RS10750	COG2363	Small membrane protein
C8233_RS10760	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C8233_RS10775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C8233_RS10785	COG0606	chelatase, subunit chli
C8233_RS10805	COG0004	ammonium transporteR
C8233_RS10820	COG0583	DNA-binding transcription factor activity
C8233_RS10840	COG1126	abc transporter atp-binding protein
C8233_RS10845	COG0765	amino acid transport
C8233_RS10850	COG4597	amino acid ABC transporter
C8233_RS10855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C8233_RS10860	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C8233_RS10870	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C8233_RS10875	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C8233_RS10880	COG1272	protein, Hemolysin III
C8233_RS10895	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C8233_RS10900	COG0142	geranyltranstransferase activity
C8233_RS10905	COG1722	exodeoxyribonuclease VII activity
C8233_RS10910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C8233_RS10915	COG1942	4-Oxalocrotonate Tautomerase
C8233_RS10920	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C8233_RS10925	COG0540	Belongs to the ATCase OTCase family
C8233_RS10930	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C8233_RS10935	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C8233_RS10940	COG1678	Uncharacterized ACR, COG1678
C8233_RS10950	COG0189	ligase activity
C8233_RS10955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C8233_RS10960	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C8233_RS10965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C8233_RS10970	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C8233_RS10975	COG4942	peptidase
C8233_RS10980	COG0793	Belongs to the peptidase S41A family
C8233_RS10985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C8233_RS10990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C8233_RS10995	COG0006	proline dipeptidase activity
C8233_RS11015	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C8233_RS11020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C8233_RS11025	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C8233_RS11045	COG1349	DNA-binding transcription factor activity
C8233_RS11050	COG1519	Transferase
C8233_RS11055	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C8233_RS11055	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C8233_RS11060	COG0859	PFAM glycosyl transferase family 9
C8233_RS11065	COG3642	lipopolysaccharide core region biosynthetic process
C8233_RS11070	COG1368	sulfuric ester hydrolase activity
C8233_RS11080	COG0297	glycogen (starch) synthase activity
C8233_RS11095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C8233_RS11100	COG0752	glycyl-tRNA synthetase alpha subunit
C8233_RS11105	COG0751	glycine-tRNA ligase activity
C8233_RS11110	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C8233_RS11130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C8233_RS11135	COG0592	DNA-directed DNA polymerase activity
C8233_RS11140	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C8233_RS11145	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C8233_RS11150	COG0594	ribonuclease P activity
C8233_RS11155	COG0706	membrane insertase activity
C8233_RS11160	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C8233_RS11170	COG1132	(ABC) transporter
C8233_RS11175	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C8233_RS11180	COG2885	chlorophyll binding
C8233_RS11185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C8233_RS11190	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C8233_RS11240	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C8233_RS11250	COG1981	membrane
C8233_RS11255	COG0038	chloride channel
C8233_RS11260	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C8233_RS11265	COG0316	Belongs to the HesB IscA family
C8233_RS11270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C8233_RS11275	COG0765	amino acid transport
C8233_RS11280	COG1126	abc transporter atp-binding protein
C8233_RS11285	COG0445	tRNA wobble uridine modification
C8233_RS11290	COG0357	Ribosomal RNA small subunit methyltransferase G
C8233_RS11295	COG1192	Involved in chromosome partitioning
C8233_RS11300	COG1475	DNA binding
C8233_RS11305	COG3312	ion transport
C8233_RS11310	COG0356	it plays a direct role in the translocation of protons across the membrane
C8233_RS11320	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C8233_RS11325	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C8233_RS11330	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C8233_RS11335	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C8233_RS11340	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C8233_RS11345	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C8233_RS11350	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C8233_RS11355	COG1349	DNA-binding transcription factor activity
C8233_RS11360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C8233_RS11365	COG1187	pseudouridine synthase activity
C8233_RS11380	COG0733	neurotransmitter:sodium symporter activity
C8233_RS11390	COG1737	Transcriptional regulator
C8233_RS11395	COG0210	DNA helicase
C8233_RS11400	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C8233_RS11405	COG1607	acyl-coa hydrolase
C8233_RS11415	COG0573	inorganic phosphate transmembrane transporter activity
C8233_RS11420	COG0573	inorganic phosphate transmembrane transporter activity
C8233_RS11425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C8233_RS11430	COG0704	Plays a role in the regulation of phosphate uptake
C8233_RS11435	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C8233_RS11450	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C8233_RS11455	COG3161	chorismate lyase activity
C8233_RS11480	COG1289	transmembrane transporter activity
C8233_RS11505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C8233_RS11510	COG1758	RNA polymerase activity
C8233_RS11515	COG0194	GDP metabolic process
C8233_RS11520	COG2814	Major facilitator Superfamily
C8233_RS11530	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C8233_RS11535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C8233_RS11540	COG1764	response to oxidative stress
C8233_RS11550	COG1561	YicC-like family, N-terminal region
C8233_RS11555	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C8233_RS11560	COG0708	Exodeoxyribonuclease III
C8233_RS11565	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C8233_RS11575	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C8233_RS11600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C8233_RS11610	COG1217	gtp-binding protein TYPA
C8233_RS11640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C8233_RS11660	COG0023	Translation Initiation Factor
C8233_RS11670	COG0126	phosphoglycerate kinase activity
C8233_RS11675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C8233_RS11680	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C8233_RS11685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C8233_RS11690	COG1451	nucleotide metabolic process
C8233_RS11730	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C8233_RS11745	COG0339	signal peptide processing
C8233_RS11750	COG0733	neurotransmitter:sodium symporter activity
C8233_RS11755	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C8233_RS11765	COG2204	response regulator
C8233_RS11785	COG1620	l-lactate permease
C8233_RS11835	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C8233_RS11835	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C8233_RS11840	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C8233_RS11875	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C8233_RS11880	COG0081	regulation of translation
C8233_RS11885	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C8233_RS11890	COG0222	ribosome binding
C8233_RS11895	COG0085	RNA polymerase activity
C8233_RS11900	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C8233_RS11905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C8233_RS11910	COG0049	tRNA binding
C8233_RS11915	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C8233_RS11920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C8233_RS11925	COG0051	transcription antitermination factor activity, RNA binding
C8233_RS11930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C8233_RS11935	COG0088	Forms part of the polypeptide exit tunnel
C8233_RS11940	COG0089	rRNA binding
C8233_RS11945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C8233_RS11950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C8233_RS11955	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C8233_RS11960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C8233_RS11965	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C8233_RS11970	COG0255	Belongs to the universal ribosomal protein uL29 family
C8233_RS11975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C8233_RS11980	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C8233_RS11985	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C8233_RS11990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C8233_RS11995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C8233_RS12000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C8233_RS12005	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C8233_RS12010	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C8233_RS12015	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C8233_RS12020	COG1841	ribosomal large subunit assembly
C8233_RS12025	COG0200	Binds to the 23S rRNA
C8233_RS12035	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C8233_RS12040	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C8233_RS12045	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C8233_RS12050	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C8233_RS12055	COG0202	RNA polymerase activity
C8233_RS12060	COG0203	ribosomal protein L17
C8233_RS12070	COG2814	Major facilitator Superfamily
C8233_RS12075	COG0629	single-stranded DNA binding
C8233_RS12080	COG5002	protein histidine kinase activity
C8233_RS12080	COG5001	Diguanylate cyclase
C8233_RS12100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C8233_RS12130	COG0300	oxidoreductase activity
C8233_RS12140	COG0415	Belongs to the DNA photolyase family
C8233_RS12145	COG0789	Transcriptional regulator
C8233_RS12150	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C8233_RS12155	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C8233_RS12160	COG1090	epimerase
C8233_RS12165	COG0564	pseudouridine synthase activity
C8233_RS12170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C8233_RS12175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C8233_RS12195	COG0142	geranyltranstransferase activity
C8233_RS12200	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C8233_RS12205	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C8233_RS12210	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C8233_RS12215	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C8233_RS12220	COG0268	Binds directly to 16S ribosomal RNA
C8233_RS12225	COG0728	peptidoglycan biosynthetic process
C8233_RS12230	COG0196	riboflavin kinase activity
C8233_RS12235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C8233_RS12240	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C8233_RS12245	COG1047	Peptidyl-prolyl cis-trans
C8233_RS12250	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C8233_RS12300	COG4969	Belongs to the N-Me-Phe pilin family
C8233_RS12340	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C8233_RS12340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C8233_RS12365	COG0028	Belongs to the TPP enzyme family
C8233_RS12370	COG0440	acetolactate synthase activity
C8233_RS12380	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C8233_RS12385	COG1183	phosphatidylcholine synthase activity
C8233_RS12415	COG3022	response to hydroperoxide
C8233_RS12420	COG3238	Protein conserved in bacteria
C8233_RS12425	COG0667	Aldo Keto reductase
C8233_RS12455	COG0733	neurotransmitter:sodium symporter activity
C8233_RS12490	COG1115	amino acid carrier protein
C8233_RS12495	COG0589	response to stress
C8233_RS12505	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C8233_RS12510	COG3118	belongs to the thioredoxin family
C8233_RS12535	COG1028	Short-chain dehydrogenase reductase Sdr
C8233_RS12545	COG0850	regulation of cytokinetic process
C8233_RS12550	COG2894	cell division
C8233_RS12555	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C8233_RS12560	COG2925	Exonuclease
C8233_RS12585	COG2814	Major facilitator Superfamily
C8233_RS12590	COG4536	flavin adenine dinucleotide binding
C8233_RS12595	COG4137	Cytochrome C assembly protein
C8233_RS12600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C8233_RS12605	COG0228	four-way junction DNA binding
C8233_RS12610	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C8233_RS12615	COG0336	Belongs to the RNA methyltransferase TrmD family
C8233_RS12620	COG0335	large ribosomal subunit rRNA binding
C8233_RS12625	COG4974	Belongs to the 'phage' integrase family
C8233_RS12630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C8233_RS12645	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C8233_RS12675	COG2217	Heavy metal translocating P-type atpase
C8233_RS12680	COG0789	Transcriptional regulator
C8233_RS12695	COG4172	Belongs to the ABC transporter superfamily
C8233_RS12700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C8233_RS12705	COG0601	transmembrane transport
C8233_RS12710	COG4166	transmembrane transport
C8233_RS12715	COG4166	transmembrane transport
C8233_RS12725	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C8233_RS12735	COG0271	Belongs to the BolA IbaG family
C8233_RS12745	COG0456	acetyltransferase
C8233_RS12755	COG0742	ribosomal rna small subunit methyltransferase
C8233_RS12760	COG0552	protein localization to endoplasmic reticulum
C8233_RS12765	COG2884	Cell division ATP-binding protein ftsE
C8233_RS12770	COG2177	Part of the ABC transporter FtsEX involved in
C8233_RS12780	COG5001	Diguanylate cyclase
C8233_RS12780	COG3300	MHYT domain
C8233_RS12785	COG1309	transcriptional regulator
C8233_RS12790	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C8233_RS12800	COG0756	dUTP diphosphatase activity
C8233_RS12810	COG2003	Belongs to the UPF0758 family
C8233_RS12815	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C8233_RS12820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C8233_RS12825	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C8233_RS12830	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C8233_RS12845	COG0686	Belongs to the AlaDH PNT family
C8233_RS12850	COG0180	Tryptophanyl-tRNA synthetase
C8233_RS12855	COG2391	methyltransferase activity
C8233_RS12875	COG0450	alkyl hydroperoxide reductase
C8233_RS12880	COG0492	ferredoxin-NADP+ reductase activity
C8233_RS12885	COG2900	Belongs to the SlyX family
C8233_RS12900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C8233_RS12905	COG2171	N-acyltransferase activity
C8233_RS12910	COG1393	Belongs to the ArsC family
C8233_RS12915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C8233_RS12920	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C8233_RS12930	COG0052	Belongs to the universal ribosomal protein uS2 family
C8233_RS12935	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C8233_RS12940	COG0528	UMP kinase activity
C8233_RS12945	COG0233	cytoplasmic translational termination
C8233_RS12960	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C8233_RS12970	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C8233_RS12980	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C8233_RS12985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C8233_RS12990	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C8233_RS12995	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C8233_RS13000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C8233_RS13010	COG0825	malonyl-CoA metabolic process
C8233_RS13015	COG0037	tRNA processing
C8233_RS13035	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C8233_RS13045	COG1028	Short-chain dehydrogenase reductase Sdr
C8233_RS13085	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C8233_RS13095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C8233_RS13100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C8233_RS13105	COG0140	phosphoribosyl-ATP diphosphatase activity
C8233_RS13110	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C8233_RS13120	COG2226	methyltransferase
C8233_RS13130	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C8233_RS13135	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C8233_RS13145	COG0018	arginyl-trna synthetase
C8233_RS13150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C8233_RS13155	COG0254	rRNA binding
C8233_RS13160	COG0281	malic enzyme
C8233_RS13200	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C8233_RS13205	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C8233_RS13210	COG0067	glutamate synthase
C8233_RS13210	COG0069	glutamate synthase activity
C8233_RS13210	COG0070	glutamate synthase
C8233_RS13215	COG0493	'glutamate synthase
C8233_RS13220	COG0504	CTP synthase activity
C8233_RS13225	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C8233_RS13230	COG0148	phosphopyruvate hydratase activity
C8233_RS13235	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C8233_RS13240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C8233_RS13245	COG1546	Belongs to the CinA family
C8233_RS13250	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C8233_RS13255	COG2137	regulation of response to DNA damage stimulus
C8233_RS13260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C8233_RS13265	COG0527	aspartate kinase activity
C8233_RS13270	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C8233_RS13300	COG0511	ligase activity, forming carbon-carbon bonds
C8233_RS13300	COG5016	pyruvate
C8233_RS13305	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C8233_RS13315	COG2818	Glycosylase
C8233_RS13330	COG0625	glutathione transferase activity
C8233_RS13340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C8233_RS13345	COG2169	Transcriptional regulator
C8233_RS13345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C8233_RS13350	COG1607	acyl-coa hydrolase
C8233_RS13355	COG2031	fatty acid transporter
C8233_RS13360	COG0534	Mate efflux family protein
C8233_RS13370	COG3706	GGDEF domain
C8233_RS13375	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C8233_RS13380	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C8233_RS13390	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C8233_RS13415	COG0604	alcohol dehydrogenase
C8233_RS13420	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C8233_RS13425	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C8233_RS13440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C8233_RS13445	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C8233_RS13450	COG1765	OsmC-like protein
C8233_RS13455	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C8233_RS13460	COG3178	'Phosphotransferase
C8233_RS13465	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C8233_RS13470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C8233_RS13475	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C8233_RS13480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C8233_RS13485	COG2967	ApaG domain
C8233_RS13490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C8233_RS13495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C8233_RS13505	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C8233_RS13510	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C8233_RS13515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C8233_RS13520	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C8233_RS13525	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C8233_RS13530	COG0358	DNA primase activity
C8233_RS13550	COG0583	DNA-binding transcription factor activity
C8233_RS13555	COG1760	l-serine dehydratase
C8233_RS13575	COG0559	Belongs to the binding-protein-dependent transport system permease family
C8233_RS13590	COG2146	nitrite reductase [NAD(P)H] activity
C8233_RS13590	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C8233_RS13595	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C8233_RS13600	COG0243	molybdopterin cofactor binding
C8233_RS13605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C8233_RS13605	COG1648	precorrin-2 dehydrogenase activity
C8233_RS13630	COG1946	Acyl-CoA thioesterase
C8233_RS13645	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C8233_RS13655	COG0069	glutamate synthase activity
C8233_RS13665	COG1061	Type III restriction enzyme res subunit
C8233_RS13670	COG0180	Tryptophanyl-tRNA synthetase
C8233_RS13675	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C8233_RS13680	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C8233_RS13705	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C8233_RS13715	COG0425	Belongs to the sulfur carrier protein TusA family
C8233_RS13725	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C8233_RS13730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C8233_RS13740	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C8233_RS13745	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C8233_RS13760	COG0235	Class ii aldolase
C8233_RS13765	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C8233_RS13780	COG1028	Short-chain dehydrogenase reductase Sdr
C8233_RS13810	COG0861	Integral membrane protein TerC family
C8233_RS13815	COG0563	adenylate kinase activity
C8233_RS13825	COG1968	undecaprenyl-diphosphatase activity
C8233_RS13830	COG0742	ribosomal rna small subunit methyltransferase
C8233_RS13835	COG2937	Belongs to the GPAT DAPAT family
C8233_RS13850	COG3091	SprT-like family
C8233_RS13855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C8233_RS13860	COG0697	spore germination
C8233_RS13870	COG0784	Response regulator, receiver
C8233_RS13870	COG2198	Histidine kinase
C8233_RS13870	COG2205	protein histidine kinase activity
C8233_RS13880	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C8233_RS13900	COG0037	tRNA processing
C8233_RS13905	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C8233_RS13910	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C8233_RS13915	COG0385	Bile acid
C8233_RS13920	COG3148	PFAM DTW domain containing protein
C8233_RS13925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C8233_RS13930	COG0569	domain protein
C8233_RS13940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C8233_RS13945	COG0242	peptide deformylase activity
C8233_RS13950	COG1652	LysM domain
C8233_RS13955	COG0758	DNA mediated transformation
C8233_RS13965	COG0009	L-threonylcarbamoyladenylate synthase
C8233_RS13970	COG0408	coproporphyrinogen oxidase activity
C8233_RS13975	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C8233_RS13980	COG0745	RESPONSE REGULATOR receiver
C8233_RS14015	COG1160	GTP binding
C8233_RS14025	COG2976	Protein conserved in bacteria
C8233_RS14035	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C8233_RS14040	COG1426	Protein conserved in bacteria
C8233_RS14050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C8233_RS14055	COG0105	UTP biosynthetic process
C8233_RS14100	COG1862	Preprotein translocase
C8233_RS14105	COG0343	queuine tRNA-ribosyltransferase activity
C8233_RS14110	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C8233_RS14150	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C8233_RS14200	COG0714	Associated with various cellular activities
C8233_RS14220	COG2274	protein secretion by the type I secretion system
C8233_RS14230	COG1538	Outer membrane efflux protein
C8233_RS14250	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C8233_RS14275	COG1012	belongs to the aldehyde dehydrogenase family
C8233_RS14280	COG3724	N-succinylarginine dihydrolase activity
C8233_RS14290	COG0519	Catalyzes the synthesis of GMP from XMP
C8233_RS14335	COG4160	amino acid transport
C8233_RS14345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C8233_RS14355	COG2988	succinylglutamate desuccinylase activity
C8233_RS14385	COG3228	Belongs to the MtfA family
C8233_RS14390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C8233_RS14390	COG3153	acetyltransferase
C8233_RS14400	COG0625	glutathione transferase activity
C8233_RS14405	COG0583	DNA-binding transcription factor activity
C8233_RS14410	COG0725	ABC transporter, periplasmic molybdate-binding protein
C8233_RS14415	COG4149	molybdate abc transporter
C8233_RS14425	COG3217	Mosc domain protein beta barrel domain protein
C8233_RS14425	COG0633	Ferredoxin
C8233_RS14430	COG0123	including yeast histone deacetylase and acetoin utilization protein
C8233_RS14450	COG1609	Transcriptional regulator
C8233_RS14460	COG1105	Belongs to the carbohydrate kinase PfkB family
C8233_RS14465	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C8233_RS14465	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C8233_RS14465	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C8233_RS14470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C8233_RS14485	COG0745	RESPONSE REGULATOR receiver
C8233_RS14490	COG2205	protein histidine kinase activity
C8233_RS14495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C8233_RS14500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C8233_RS14505	COG2610	gluconate transmembrane transporter activity
C8233_RS14510	COG3265	gluconokinase activity
C8233_RS14515	COG1609	Transcriptional regulator
C8233_RS14520	COG2431	L-lysine efflux transmembrane transporter activity
C8233_RS14530	COG0693	protein deglycase activity
C8233_RS14540	COG1522	sequence-specific DNA binding
C8233_RS14550	COG0006	proline dipeptidase activity
C8233_RS14555	COG3608	succinylglutamate desuccinylase aspartoacylase
C8233_RS14560	COG1522	sequence-specific DNA binding
C8233_RS14570	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C8233_RS14575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C8233_RS14580	COG2902	Dehydrogenase
C8233_RS14590	COG0167	dihydroorotate dehydrogenase activity
C8233_RS14595	COG3130	regulation of translation
C8233_RS14600	COG0116	Belongs to the methyltransferase superfamily
C8233_RS14600	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C8233_RS14615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C8233_RS14620	COG1757	Na H antiporter
C8233_RS14635	COG4215	(ABC) transporter
C8233_RS14640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C8233_RS14655	COG1309	transcriptional regulator
C8233_RS14660	COG0501	Belongs to the peptidase M48B family
C8233_RS14665	COG0436	Aminotransferase
C8233_RS14670	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C8233_RS14675	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C8233_RS14720	COG1131	(ABC) transporter
C8233_RS14725	COG0842	Transport permease protein
C8233_RS14730	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C8233_RS14730	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C8233_RS14735	COG0778	Nitroreductase
C8233_RS14775	COG0488	(ABC) transporter
C8233_RS14780	COG2081	HI0933 family
C8233_RS14785	COG0583	DNA-binding transcription factor activity
C8233_RS14805	COG4575	ribosome binding
C8233_RS14815	COG1196	nuclear chromosome segregation
C8233_RS14815	COG3264	Mechanosensitive ion channel
C8233_RS14835	COG3180	Ammonia monooxygenase
C8233_RS14845	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C8233_RS14850	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C8233_RS14855	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C8233_RS14865	COG3100	YcgL domain-containing protein
C8233_RS14870	COG2983	Belongs to the UPF0260 family
C8233_RS14895	COG0791	NLP P60 protein
C8233_RS14905	COG2814	Major facilitator Superfamily
C8233_RS14920	COG4134	Bacterial extracellular solute-binding protein
C8233_RS14925	COG4135	transport system, permease component
C8233_RS14930	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C8233_RS14955	COG3133	Outer membrane lipoprotein
C8233_RS14960	COG2224	Isocitrate lyase
C8233_RS14975	COG2850	peptidyl-arginine hydroxylation
C8233_RS14985	COG2915	High frequency lysogenization protein hflD homolog
C8233_RS14990	COG0482	sulfurtransferase activity
C8233_RS15015	COG0542	response to heat
C8233_RS15020	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C8233_RS15025	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C8233_RS15030	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C8233_RS15035	COG1674	ftsk spoiiie
C8233_RS15040	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C8233_RS15045	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C8233_RS15055	COG1012	belongs to the aldehyde dehydrogenase family
C8233_RS15060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C8233_RS15065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C8233_RS15070	COG2423	ornithine cyclodeaminase activity
C8233_RS15085	COG0659	secondary active sulfate transmembrane transporter activity
C8233_RS15090	COG0589	response to stress
C8233_RS15110	COG0393	Putative heavy-metal-binding
C8233_RS15115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C8233_RS15120	COG1028	Short-chain dehydrogenase reductase Sdr
C8233_RS15130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C8233_RS15160	COG2986	histidine ammonia-lyase
C8233_RS15185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C8233_RS15190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C8233_RS15205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C8233_RS15215	COG2974	May be involved in recombination
C8233_RS15225	COG0824	Thioesterase
C8233_RS15245	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C8233_RS15250	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C8233_RS15270	COG0459	protein refolding
C8233_RS15275	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C8233_RS15285	COG1028	Short-chain dehydrogenase reductase Sdr
C8233_RS15290	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C8233_RS15295	COG2183	response to ionizing radiation
C8233_RS15300	COG2918	glutathione biosynthetic process
C8233_RS15305	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C8233_RS15315	COG0579	oxidoreductase
C8233_RS15320	COG0560	Phosphoserine phosphatase
C8233_RS15340	COG0745	RESPONSE REGULATOR receiver
C8233_RS15345	COG0730	response to heat
C8233_RS15350	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C8233_RS15355	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C8233_RS15370	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C8233_RS15375	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C8233_RS15395	COG0166	Belongs to the GPI family
C8233_RS15400	COG0676	glucose-6-phosphate 1-epimerase activity
C8233_RS15405	COG0837	glucose binding
C8233_RS15425	COG5002	protein histidine kinase activity
C8233_RS15425	COG5001	Diguanylate cyclase
C8233_RS15425	COG3447	MASE1 domain protein
C8233_RS15435	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C8233_RS15460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C8233_RS15470	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C8233_RS15525	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C8233_RS15530	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C8233_RS15535	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C8233_RS15540	COG0585	pseudouridine synthase activity
C8233_RS15545	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C8233_RS15550	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C8233_RS15560	COG4942	peptidase
C8233_RS15560	COG1388	LysM domain
C8233_RS15570	COG1538	Outer membrane efflux protein
C8233_RS15575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C8233_RS15580	COG1560	Kdo2-lipid A biosynthetic process
C8233_RS15600	COG0488	(ABC) transporter
C8233_RS15610	COG1366	Belongs to the anti-sigma-factor antagonist family
C8233_RS15635	COG2326	polyphosphate kinase activity
C8233_RS15645	COG4181	ATPase activity
C8233_RS15650	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C8233_RS15655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C8233_RS15670	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C8233_RS15680	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C8233_RS15690	COG1215	transferase activity, transferring glycosyl groups
C8233_RS15700	COG2261	transglycosylase associated protein
C8233_RS15705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C8233_RS15710	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C8233_RS15710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C8233_RS15720	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C8233_RS15725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C8233_RS15735	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C8233_RS15745	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C8233_RS15755	COG0129	dihydroxy-acid dehydratase activity
C8233_RS15765	COG0433	COG0433 Predicted ATPase
C8233_RS15775	COG0494	nUDIX hydrolase
C8233_RS15780	COG1011	Hydrolase
C8233_RS15785	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C8233_RS15790	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C8233_RS15795	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C8233_RS15805	COG0442	prolyl-tRNA aminoacylation
C8233_RS15820	COG2116	formate transmembrane transporter activity
C8233_RS15845	COG0322	excinuclease ABC activity
C8233_RS15865	COG2207	Transcriptional regulator
C8233_RS15865	COG3708	Transcriptional regulator
C8233_RS15870	COG3842	ATPase activity
C8233_RS15875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C8233_RS15880	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C8233_RS15885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C8233_RS15890	COG0137	argininosuccinate synthase activity
C8233_RS15905	COG3447	MASE1 domain protein
C8233_RS15905	COG5002	protein histidine kinase activity
C8233_RS15905	COG5001	Diguanylate cyclase
C8233_RS15915	COG0697	spore germination
C8233_RS15920	COG1414	Transcriptional regulator
C8233_RS15965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C8233_RS15970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C8233_RS15975	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C8233_RS15980	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C8233_RS15980	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C8233_RS15985	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C8233_RS15985	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C8233_RS15995	COG1414	Transcriptional regulator
C8233_RS16020	COG2855	membrane
C8233_RS16040	COG2824	Alkylphosphonate utilization operon protein PhnA
C8233_RS16060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C8233_RS16065	COG1960	acyl-CoA dehydrogenase activity
C8233_RS16070	COG0517	IMP dehydrogenase activity
C8233_RS16070	COG1125	glycine betaine transport
C8233_RS16075	COG1174	glycine betaine transport
C8233_RS16105	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C8233_RS16110	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C8233_RS16115	COG1984	allophanate hydrolase subunit 2
C8233_RS16125	COG0318	PFAM AMP-dependent synthetase and ligase
C8233_RS16140	COG1960	acyl-CoA dehydrogenase activity
C8233_RS16145	COG1024	Enoyl-CoA hydratase
C8233_RS16150	COG1250	3-hydroxyacyl-CoA dehydrogenase
C8233_RS16150	COG1024	Enoyl-CoA hydratase
C8233_RS16165	COG0534	Mate efflux family protein
C8233_RS16170	COG3123	guanosine phosphorylase activity
C8233_RS16175	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C8233_RS16185	COG1301	dicarboxylic acid transport
C8233_RS16190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C8233_RS16220	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C8233_RS16225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C8233_RS16230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C8233_RS16235	COG0215	cysteine-tRNA ligase activity
C8233_RS16240	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C8233_RS16245	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C8233_RS16270	COG0544	peptidyl-prolyl cis-trans isomerase activity
C8233_RS16275	COG0740	serine-type endopeptidase activity
C8233_RS16280	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C8233_RS16285	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C8233_RS16295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C8233_RS16300	COG0583	DNA-binding transcription factor activity
C8233_RS16305	COG2130	NADP-dependent
C8233_RS16310	COG1979	alcohol dehydrogenase
C8233_RS16315	COG0523	cobalamin synthesis protein
C8233_RS16330	COG0602	queuosine metabolic process
C8233_RS16335	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C8233_RS16340	COG2203	Gaf domain
C8233_RS16340	COG4251	negative regulation of phosphorylation
C8233_RS16340	COG5001	Diguanylate cyclase
C8233_RS16340	COG3706	GGDEF domain
C8233_RS16345	COG0583	DNA-binding transcription factor activity
C8233_RS16350	COG0534	Mate efflux family protein
C8233_RS16355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C8233_RS16365	COG0583	DNA-binding transcription factor activity
C8233_RS16375	COG2154	pterin-4-alpha-carbinolamine dehydratase
C8233_RS16405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C8233_RS16415	COG1063	alcohol dehydrogenase
C8233_RS16420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C8233_RS16445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C8233_RS16450	COG0786	glutamate:sodium symporter activity
C8233_RS16455	COG0471	metal ion transport
C8233_RS16460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C8233_RS16465	COG1218	3'(2'),5'-bisphosphate nucleotidase
C8233_RS16470	COG2194	sulfuric ester hydrolase activity
C8233_RS16480	COG0438	transferase activity, transferring glycosyl groups
C8233_RS16490	COG1473	amidohydrolase
C8233_RS16505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C8233_RS16515	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C8233_RS16520	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C8233_RS16525	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C8233_RS16530	COG0072	phenylalanine-tRNA ligase activity
C8233_RS16535	COG0776	regulation of translation
C8233_RS16540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C8233_RS16545	COG0569	domain protein
C8233_RS16550	COG0733	neurotransmitter:sodium symporter activity
C8233_RS16555	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C8233_RS16565	COG0776	regulation of translation
C8233_RS16570	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C8233_RS16580	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C8233_RS16585	COG1289	transmembrane transporter activity
C8233_RS16605	COG1349	DNA-binding transcription factor activity
C8233_RS16610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C8233_RS16615	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C8233_RS16620	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C8233_RS16645	COG1956	GAF domain-containing protein
C8233_RS16650	COG1464	Belongs to the NlpA lipoprotein family
C8233_RS16655	COG2011	ABC-type metal ion transport system permease component
C8233_RS16660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C8233_RS16665	COG0307	riboflavin synthase, alpha
C8233_RS16670	COG2252	PERMEase
C8233_RS16675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C8233_RS16680	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C8233_RS16685	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C8233_RS16700	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C8233_RS16710	COG0438	transferase activity, transferring glycosyl groups
C8233_RS16715	COG1396	sequence-specific DNA binding
C8233_RS16715	COG1917	Cupin 2, conserved barrel domain protein
C8233_RS16720	COG3852	Histidine kinase
C8233_RS16735	COG4662	Binding-protein-dependent transport system inner membrane component
C8233_RS16745	COG0746	molybdenum cofactor guanylyltransferase activity
C8233_RS16750	COG1763	Mo-molybdopterin cofactor biosynthetic process
C8233_RS16755	COG0303	'Molybdopterin
C8233_RS16760	COG0315	cyclic pyranopterin monophosphate synthase activity
C8233_RS16765	COG0314	molybdopterin synthase activity
C8233_RS16770	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C8233_RS16785	COG0788	formyltetrahydrofolate deformylase activity
C8233_RS16790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C8233_RS16795	COG2056	Na+-H+ antiporter family
C8233_RS16825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C8233_RS16850	COG0189	ligase activity
C8233_RS16860	COG1666	GTP binding
C8233_RS16865	COG2996	Protein conserved in bacteria
C8233_RS16870	COG1929	Belongs to the glycerate kinase type-1 family
C8233_RS16880	COG0308	aminopeptidase N
C8233_RS16895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C8233_RS16900	COG4660	Part of a membrane complex involved in electron transport
C8233_RS16905	COG4659	FMN binding
C8233_RS16910	COG4658	electron transport chain
C8233_RS16925	COG2878	Part of a membrane complex involved in electron transport
C8233_RS16930	COG4657	Part of a membrane complex involved in electron transport
C8233_RS16940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C8233_RS16940	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C8233_RS16950	COG1785	Belongs to the alkaline phosphatase family
C8233_RS16965	COG0489	protein tyrosine kinase activity
C8233_RS16970	COG0717	Belongs to the dCTP deaminase family
C8233_RS16975	COG3240	lipase activity
C8233_RS16975	COG4625	pathogenesis
C8233_RS16980	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C8233_RS16985	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C8233_RS16990	COG0628	permease
C8233_RS16995	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C8233_RS17005	COG0432	Pfam Uncharacterised protein family UPF0047
C8233_RS17015	COG0583	DNA-binding transcription factor activity
C8233_RS17035	COG1611	Belongs to the LOG family
C8233_RS17050	COG0427	acetyl-CoA hydrolase
C8233_RS17060	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C8233_RS17090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C8233_RS17110	COG0438	transferase activity, transferring glycosyl groups
C8233_RS17115	COG1215	transferase activity, transferring glycosyl groups
C8233_RS17130	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C8233_RS17155	COG0438	transferase activity, transferring glycosyl groups
C8233_RS17165	COG1596	polysaccharide export
C8233_RS17170	COG0489	protein tyrosine kinase activity
C8233_RS17170	COG3206	protein involved in exopolysaccharide biosynthesis
C8233_RS17175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C8233_RS17190	COG2244	polysaccharide biosynthetic process
C8233_RS17220	COG0438	transferase activity, transferring glycosyl groups
C8233_RS17235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C8233_RS17245	COG4303	Ethanolamine ammonia lyase large subunit
C8233_RS17250	COG4302	ethanolamine ammonia-lyase activity
C8233_RS17255	COG0531	amino acid
C8233_RS17260	COG0352	thiamine-phosphate diphosphorylase activity
C8233_RS17270	COG3568	Endonuclease Exonuclease Phosphatase
C8233_RS17270	COG1555	photosystem II stabilization
C8233_RS17280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C8233_RS17285	COG1120	ATPase activity
C8233_RS17345	COG0583	DNA-binding transcription factor activity
C8233_RS17350	COG3791	Glutathione-dependent formaldehyde-activating
C8233_RS17365	COG2175	clavaminate synthase activity
C8233_RS17380	COG5001	Diguanylate cyclase
C8233_RS17415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C8233_RS17435	COG0583	DNA-binding transcription factor activity
C8233_RS17440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C8233_RS17485	COG5642	Protein of unknown function (DUF2384)
C8233_RS17505	COG0583	DNA-binding transcription factor activity
C8233_RS17510	COG1012	belongs to the aldehyde dehydrogenase family
C8233_RS17535	COG0251	oxidation-reduction process
C8233_RS17545	COG1294	oxidase, subunit
C8233_RS17550	COG1271	oxidase subunit
C8233_RS17555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C8233_RS17585	COG0829	nickel cation binding
C8233_RS17590	COG0831	urea catabolic process
C8233_RS17595	COG0832	Belongs to the urease beta subunit family
C8233_RS17600	COG0804	urea catabolic process
C8233_RS17605	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C8233_RS17610	COG0830	nickel cation binding
C8233_RS17615	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C8233_RS17630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C8233_RS17650	COG1469	GTP cyclohydrolase I activity
C8233_RS17655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C8233_RS17665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C8233_RS17665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C8233_RS17675	COG0583	DNA-binding transcription factor activity
C8233_RS17690	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C8233_RS17695	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C8233_RS17700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C8233_RS17710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C8233_RS17720	COG4948	Mandelate Racemase Muconate Lactonizing
C8233_RS17730	COG2186	Transcriptional regulator
C8233_RS17735	COG1396	sequence-specific DNA binding
C8233_RS17750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C8233_RS17755	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C8233_RS17760	COG2070	2-Nitropropane dioxygenase
C8233_RS17765	COG0028	Belongs to the TPP enzyme family
C8233_RS17770	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C8233_RS17790	COG1596	polysaccharide export
C8233_RS17800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C8233_RS17805	COG1132	(ABC) transporter
C8233_RS17815	COG1215	transferase activity, transferring glycosyl groups
C8233_RS17820	COG1216	Glycosyl transferase, family 2
C8233_RS17830	COG0438	transferase activity, transferring glycosyl groups
C8233_RS17835	COG0438	transferase activity, transferring glycosyl groups
C8233_RS17850	COG3307	-O-antigen
C8233_RS17860	COG0156	8-amino-7-oxononanoate synthase activity
C8233_RS17870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C8233_RS17875	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C8233_RS17905	COG0604	alcohol dehydrogenase
C8233_RS17905	COG1028	Short-chain dehydrogenase reductase Sdr
C8233_RS17905	COG3321	synthase
C8233_RS17915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C8233_RS17920	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC