locus-tag	class	description
E4T21_RS00030	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E4T21_RS00055	COG2996	Protein conserved in bacteria
E4T21_RS00060	COG0189	ligase activity
E4T21_RS00065	COG1678	Uncharacterized ACR, COG1678
E4T21_RS00070	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E4T21_RS00075	COG0540	Belongs to the ATCase OTCase family
E4T21_RS00080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T21_RS00105	COG1288	antiporter activity
E4T21_RS00125	COG0625	glutathione transferase activity
E4T21_RS00170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4T21_RS00180	COG0142	geranyltranstransferase activity
E4T21_RS00185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4T21_RS00190	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4T21_RS00195	COG0583	DNA-binding transcription factor activity
E4T21_RS00205	COG1757	Na H antiporter
E4T21_RS00210	COG3153	acetyltransferase
E4T21_RS00210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4T21_RS00220	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4T21_RS00225	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4T21_RS00235	COG0346	lactoylglutathione lyase activity
E4T21_RS00245	COG2960	long-chain fatty acid transporting porin activity
E4T21_RS00255	COG0004	ammonium transporteR
E4T21_RS00265	COG3530	Putative quorum-sensing-regulated virulence factor
E4T21_RS00285	COG0583	DNA-binding transcription factor activity
E4T21_RS00295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4T21_RS00315	COG0709	Synthesizes selenophosphate from selenide and ATP
E4T21_RS00320	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E4T21_RS00345	COG0107	imidazoleglycerol-phosphate synthase activity
E4T21_RS00350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E4T21_RS00355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4T21_RS00360	COG0131	Imidazoleglycerol-phosphate dehydratase
E4T21_RS00375	COG1194	a g-specific adenine glycosylase
E4T21_RS00380	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E4T21_RS00495	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4T21_RS00640	COG4695	Portal protein
E4T21_RS00660	COG2814	Major facilitator Superfamily
E4T21_RS00670	COG0436	Aminotransferase
E4T21_RS00680	COG3433	isochorismatase activity
E4T21_RS00680	COG1535	isochorismatase
E4T21_RS00690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E4T21_RS00695	COG0625	glutathione transferase activity
E4T21_RS00700	COG1454	alcohol dehydrogenase
E4T21_RS00715	COG0175	sulfate reduction
E4T21_RS00720	COG0583	DNA-binding transcription factor activity
E4T21_RS00725	COG0583	DNA-binding transcription factor activity
E4T21_RS00735	COG2807	transmembrane transport
E4T21_RS00740	COG1414	Transcriptional regulator
E4T21_RS00760	COG3971	2-oxopent-4-enoate hydratase activity
E4T21_RS00770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4T21_RS00775	COG2814	Major facilitator Superfamily
E4T21_RS00785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4T21_RS00800	COG2175	clavaminate synthase activity
E4T21_RS00815	COG1764	response to oxidative stress
E4T21_RS00830	COG1289	transmembrane transporter activity
E4T21_RS00835	COG0318	PFAM AMP-dependent synthetase and ligase
E4T21_RS00840	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4T21_RS00850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4T21_RS00855	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4T21_RS00870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4T21_RS00875	COG1757	Na H antiporter
E4T21_RS00925	COG1929	Belongs to the glycerate kinase type-1 family
E4T21_RS00930	COG1132	(ABC) transporter
E4T21_RS00935	COG3284	Transcriptional regulator
E4T21_RS00945	COG1063	alcohol dehydrogenase
E4T21_RS00955	COG2080	2 iron, 2 sulfur cluster binding
E4T21_RS00960	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4T21_RS00965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4T21_RS00990	COG2207	Transcriptional regulator
E4T21_RS01005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T21_RS01040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T21_RS01065	COG0583	DNA-binding transcription factor activity
E4T21_RS01080	COG2895	sulfate adenylyltransferase (ATP) activity
E4T21_RS01085	COG0175	sulfate reduction
E4T21_RS01090	COG1218	3'(2'),5'-bisphosphate nucleotidase
E4T21_RS01095	COG0156	8-amino-7-oxononanoate synthase activity
E4T21_RS01100	COG0604	alcohol dehydrogenase
E4T21_RS01100	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS01100	COG3321	synthase
E4T21_RS01135	COG0438	transferase activity, transferring glycosyl groups
E4T21_RS01135	COG1216	Glycosyl transferase, family 2
E4T21_RS01175	COG0033	Phosphoglucomutase
E4T21_RS01180	COG0166	Belongs to the GPI family
E4T21_RS01185	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E4T21_RS01195	COG1088	dTDP-glucose 4,6-dehydratase activity
E4T21_RS01225	COG2197	response regulator
E4T21_RS01230	COG3539	Fimbrial protein
E4T21_RS01235	COG3121	Chaperone
E4T21_RS01240	COG3188	usher protein
E4T21_RS01250	COG3119	arylsulfatase activity
E4T21_RS01290	COG4336	lyase activity
E4T21_RS01295	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS01305	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4T21_RS01325	COG0028	Belongs to the TPP enzyme family
E4T21_RS01335	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
E4T21_RS01340	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS01345	COG2226	methyltransferase
E4T21_RS01345	COG1073	alpha beta
E4T21_RS01360	COG1414	Transcriptional regulator
E4T21_RS01375	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS01390	COG2146	nitrite reductase [NAD(P)H] activity
E4T21_RS01400	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
E4T21_RS01410	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E4T21_RS01415	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E4T21_RS01420	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
E4T21_RS01425	COG2205	protein histidine kinase activity
E4T21_RS01445	COG1305	Transglutaminase-like
E4T21_RS01450	COG2308	Evidence 4 Homologs of previously reported genes of
E4T21_RS01465	COG0454	-acetyltransferase
E4T21_RS01490	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4T21_RS01495	COG1166	arginine decarboxylase activity
E4T21_RS01525	COG0402	S-adenosylhomocysteine deaminase activity
E4T21_RS01535	COG0583	DNA-binding transcription factor activity
E4T21_RS01550	COG1840	ABC-type Fe3 transport system, periplasmic component
E4T21_RS01560	COG1178	ABC-type Fe3 transport system permease component
E4T21_RS01575	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E4T21_RS01580	COG1444	tRNA N-acetyltransferase activity
E4T21_RS01585	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4T21_RS01595	COG0783	Belongs to the Dps family
E4T21_RS01600	COG1929	Belongs to the glycerate kinase type-1 family
E4T21_RS01645	COG1607	acyl-coa hydrolase
E4T21_RS01650	COG2031	fatty acid transporter
E4T21_RS01655	COG0534	Mate efflux family protein
E4T21_RS01660	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4T21_RS01665	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4T21_RS01680	COG0583	DNA-binding transcription factor activity
E4T21_RS01705	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4T21_RS01715	COG2197	response regulator
E4T21_RS01720	COG2205	protein histidine kinase activity
E4T21_RS01720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T21_RS01735	COG2274	protein secretion by the type I secretion system
E4T21_RS01740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T21_RS01750	COG4948	Mandelate Racemase Muconate Lactonizing
E4T21_RS01755	COG4829	muconolactone delta-isomerase
E4T21_RS01780	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS01800	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E4T21_RS01835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4T21_RS01840	COG0081	regulation of translation
E4T21_RS01845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4T21_RS01850	COG0222	ribosome binding
E4T21_RS01860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4T21_RS01865	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4T21_RS01870	COG0049	tRNA binding
E4T21_RS01875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4T21_RS01880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4T21_RS01885	COG0051	transcription antitermination factor activity, RNA binding
E4T21_RS01890	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4T21_RS01895	COG0088	Forms part of the polypeptide exit tunnel
E4T21_RS01900	COG0089	rRNA binding
E4T21_RS01905	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4T21_RS01910	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4T21_RS01915	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4T21_RS01920	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4T21_RS01925	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4T21_RS01930	COG0255	Belongs to the universal ribosomal protein uL29 family
E4T21_RS01935	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4T21_RS01940	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4T21_RS01945	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4T21_RS01950	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4T21_RS01955	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4T21_RS01960	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4T21_RS01965	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4T21_RS01970	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4T21_RS01975	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4T21_RS01980	COG1841	ribosomal large subunit assembly
E4T21_RS01985	COG0200	Binds to the 23S rRNA
E4T21_RS01995	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4T21_RS02000	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4T21_RS02005	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4T21_RS02010	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4T21_RS02015	COG0202	RNA polymerase activity
E4T21_RS02020	COG0203	ribosomal protein L17
E4T21_RS02045	COG2814	Major facilitator Superfamily
E4T21_RS02050	COG0629	single-stranded DNA binding
E4T21_RS02055	COG1609	Transcriptional regulator
E4T21_RS02065	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4T21_RS02080	COG0673	inositol 2-dehydrogenase activity
E4T21_RS02100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4T21_RS02115	COG1090	epimerase
E4T21_RS02125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4T21_RS02160	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E4T21_RS02165	COG3639	organic phosphonate transmembrane transporter activity
E4T21_RS02170	COG2188	Transcriptional regulator
E4T21_RS02175	COG3624	Phosphonate C-P lyase system protein PhnG
E4T21_RS02185	COG3626	phosphonate metabolism
E4T21_RS02190	COG3627	carbon phosphorus lyase activity
E4T21_RS02195	COG4107	phosphonate C-P lyase system protein PhnK
E4T21_RS02200	COG4778	phosphonate C-P lyase system protein PhnL
E4T21_RS02205	COG3454	Phosphonate metabolism
E4T21_RS02210	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E4T21_RS02215	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E4T21_RS02225	COG0656	L-ascorbic acid biosynthetic process
E4T21_RS02230	COG2814	Major facilitator Superfamily
E4T21_RS02235	COG0583	DNA-binding transcription factor activity
E4T21_RS02240	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4T21_RS02250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS02255	COG2084	Dehydrogenase
E4T21_RS02275	COG1012	belongs to the aldehyde dehydrogenase family
E4T21_RS02285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4T21_RS02305	COG3314	Sporulation integral membrane protein YlbJ
E4T21_RS02315	COG2204	response regulator
E4T21_RS02320	COG1288	antiporter activity
E4T21_RS02335	COG2186	Transcriptional regulator
E4T21_RS02340	COG3386	PFAM SMP-30 Gluconolaconase
E4T21_RS02345	COG4948	Mandelate Racemase Muconate Lactonizing
E4T21_RS02365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4T21_RS02370	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS02410	COG2986	histidine ammonia-lyase
E4T21_RS02435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4T21_RS02440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4T21_RS02445	COG0204	Acyl-transferase
E4T21_RS02460	COG3422	double-strand break repair
E4T21_RS02495	COG0142	geranyltranstransferase activity
E4T21_RS02500	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4T21_RS02505	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4T21_RS02510	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4T21_RS02515	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E4T21_RS02520	COG2010	Cytochrome c
E4T21_RS02535	COG0268	Binds directly to 16S ribosomal RNA
E4T21_RS02545	COG0196	riboflavin kinase activity
E4T21_RS02550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4T21_RS02555	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4T21_RS02560	COG1047	Peptidyl-prolyl cis-trans
E4T21_RS02565	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4T21_RS02605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4T21_RS02605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4T21_RS02630	COG2814	Major facilitator Superfamily
E4T21_RS02635	COG0028	Belongs to the TPP enzyme family
E4T21_RS02640	COG0440	acetolactate synthase activity
E4T21_RS02650	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E4T21_RS02655	COG1183	phosphatidylcholine synthase activity
E4T21_RS02720	COG4172	Belongs to the ABC transporter superfamily
E4T21_RS02725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4T21_RS02730	COG0601	transmembrane transport
E4T21_RS02750	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4T21_RS02765	COG0271	Belongs to the BolA IbaG family
E4T21_RS02775	COG0456	acetyltransferase
E4T21_RS02775	COG1214	PFAM Peptidase M22, glycoprotease
E4T21_RS02785	COG1473	amidohydrolase
E4T21_RS02790	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4T21_RS02795	COG0583	DNA-binding transcription factor activity
E4T21_RS02800	COG0742	ribosomal rna small subunit methyltransferase
E4T21_RS02805	COG0552	protein localization to endoplasmic reticulum
E4T21_RS02810	COG2884	Cell division ATP-binding protein ftsE
E4T21_RS02815	COG2177	Part of the ABC transporter FtsEX involved in
E4T21_RS02830	COG1309	transcriptional regulator
E4T21_RS02835	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4T21_RS02845	COG0756	dUTP diphosphatase activity
E4T21_RS02850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4T21_RS02855	COG2003	Belongs to the UPF0758 family
E4T21_RS02860	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4T21_RS02865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4T21_RS02870	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4T21_RS02875	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4T21_RS02890	COG5002	protein histidine kinase activity
E4T21_RS02895	COG0745	RESPONSE REGULATOR receiver
E4T21_RS02900	COG0686	Belongs to the AlaDH PNT family
E4T21_RS02905	COG0180	Tryptophanyl-tRNA synthetase
E4T21_RS02925	COG0450	alkyl hydroperoxide reductase
E4T21_RS02930	COG0492	ferredoxin-NADP+ reductase activity
E4T21_RS02950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4T21_RS02960	COG1393	Belongs to the ArsC family
E4T21_RS02965	COG0436	Aminotransferase
E4T21_RS02970	COG3188	usher protein
E4T21_RS02975	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E4T21_RS02980	COG0024	Methionine aminopeptidase
E4T21_RS02985	COG0052	Belongs to the universal ribosomal protein uS2 family
E4T21_RS02990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4T21_RS02995	COG0528	UMP kinase activity
E4T21_RS03000	COG0233	cytoplasmic translational termination
E4T21_RS03005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4T21_RS03015	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4T21_RS03025	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4T21_RS03035	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4T21_RS03040	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4T21_RS03045	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4T21_RS03050	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4T21_RS03055	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4T21_RS03065	COG0825	malonyl-CoA metabolic process
E4T21_RS03070	COG0037	tRNA processing
E4T21_RS03075	COG0248	Ppx GppA phosphatase
E4T21_RS03085	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4T21_RS03110	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4T21_RS03125	COG0583	DNA-binding transcription factor activity
E4T21_RS03135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T21_RS03150	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E4T21_RS03165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4T21_RS03170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4T21_RS03175	COG0140	phosphoribosyl-ATP diphosphatase activity
E4T21_RS03180	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E4T21_RS03190	COG2226	methyltransferase
E4T21_RS03200	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4T21_RS03205	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4T21_RS03215	COG0018	arginyl-trna synthetase
E4T21_RS03220	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4T21_RS03225	COG0254	rRNA binding
E4T21_RS03230	COG0281	malic enzyme
E4T21_RS03255	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4T21_RS03260	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4T21_RS03270	COG0067	glutamate synthase
E4T21_RS03270	COG0069	glutamate synthase activity
E4T21_RS03270	COG0070	glutamate synthase
E4T21_RS03275	COG0493	'glutamate synthase
E4T21_RS03280	COG0504	CTP synthase activity
E4T21_RS03285	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E4T21_RS03290	COG0148	phosphopyruvate hydratase activity
E4T21_RS03355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4T21_RS03370	COG2217	Heavy metal translocating P-type atpase
E4T21_RS03380	COG0348	domain, Protein
E4T21_RS03385	COG2010	Cytochrome c
E4T21_RS03400	COG3278	Belongs to the heme-copper respiratory oxidase family
E4T21_RS03435	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4T21_RS03435	COG1902	pentaerythritol trinitrate reductase activity
E4T21_RS03440	COG2766	serine protein kinase
E4T21_RS03445	COG2718	Belongs to the UPF0229 family
E4T21_RS03450	COG2719	SpoVR family
E4T21_RS03485	COG0557	exoribonuclease II activity
E4T21_RS03490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4T21_RS03495	COG0360	Binds together with S18 to 16S ribosomal RNA
E4T21_RS03500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4T21_RS03515	COG1966	Carbon starvation protein
E4T21_RS03520	COG0305	Participates in initiation and elongation during chromosome replication
E4T21_RS03540	COG1320	monovalent cation:proton antiporter activity
E4T21_RS03545	COG2212	antiporter activity
E4T21_RS03550	COG1863	multisubunit Na H antiporter MnhE subunit
E4T21_RS03555	COG0651	ATP synthesis coupled electron transport
E4T21_RS03560	COG1006	Multisubunit Na H antiporter MnhC subunit
E4T21_RS03565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4T21_RS03565	COG2111	Na H antiporter
E4T21_RS03570	COG2951	lytic endotransglycosylase activity
E4T21_RS03575	COG0189	ligase activity
E4T21_RS03575	COG4067	protein conserved in archaea
E4T21_RS03580	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4T21_RS03585	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
E4T21_RS03590	COG0151	Belongs to the GarS family
E4T21_RS03600	COG3954	Phosphoribulokinase
E4T21_RS03605	COG0537	adenosine 5'-monophosphoramidase activity
E4T21_RS03610	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
E4T21_RS03615	COG1765	OsmC-like protein
E4T21_RS03620	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4T21_RS03625	COG3178	'Phosphotransferase
E4T21_RS03630	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4T21_RS03635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4T21_RS03645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4T21_RS03650	COG2967	ApaG domain
E4T21_RS03655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4T21_RS03660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4T21_RS03670	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E4T21_RS03685	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4T21_RS03690	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4T21_RS03695	COG0358	DNA primase activity
E4T21_RS03710	COG0583	DNA-binding transcription factor activity
E4T21_RS03715	COG1760	l-serine dehydratase
E4T21_RS03735	COG0583	DNA-binding transcription factor activity
E4T21_RS03740	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E4T21_RS03765	COG1902	pentaerythritol trinitrate reductase activity
E4T21_RS03765	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4T21_RS03770	COG0247	lactate metabolic process
E4T21_RS03770	COG2181	nitrate reductase activity
E4T21_RS03775	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E4T21_RS03785	COG1609	Transcriptional regulator
E4T21_RS03800	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4T21_RS03805	COG1063	alcohol dehydrogenase
E4T21_RS03815	COG3383	formate dehydrogenase (NAD+) activity
E4T21_RS03825	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4T21_RS03870	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4T21_RS03900	COG0598	Magnesium transport protein CorA
E4T21_RS03905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4T21_RS03910	COG3835	regulator
E4T21_RS03920	COG2610	gluconate transmembrane transporter activity
E4T21_RS03940	COG1595	DNA-templated transcription, initiation
E4T21_RS03955	COG4136	ATPase activity
E4T21_RS03960	COG4135	transport system, permease component
E4T21_RS03965	COG4134	Bacterial extracellular solute-binding protein
E4T21_RS03975	COG0589	response to stress
E4T21_RS03985	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4T21_RS04005	COG3220	belongs to the UPF0276 family
E4T21_RS04015	COG0251	oxidation-reduction process
E4T21_RS04025	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4T21_RS04025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4T21_RS04030	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E4T21_RS04055	COG2188	Transcriptional regulator
E4T21_RS04070	COG0583	DNA-binding transcription factor activity
E4T21_RS04075	COG2807	transmembrane transport
E4T21_RS04090	COG4989	oxidoreductase activity
E4T21_RS04095	COG0676	glucose-6-phosphate 1-epimerase activity
E4T21_RS04100	COG0837	glucose binding
E4T21_RS04115	COG2204	response regulator
E4T21_RS04155	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E4T21_RS04160	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4T21_RS04165	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4T21_RS04170	COG0585	pseudouridine synthase activity
E4T21_RS04175	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E4T21_RS04180	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E4T21_RS04190	COG1388	LysM domain
E4T21_RS04190	COG4942	peptidase
E4T21_RS04200	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4T21_RS04205	COG1560	Kdo2-lipid A biosynthetic process
E4T21_RS04215	COG0488	(ABC) transporter
E4T21_RS04240	COG4181	ATPase activity
E4T21_RS04245	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E4T21_RS04260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4T21_RS04275	COG1215	transferase activity, transferring glycosyl groups
E4T21_RS04285	COG0366	Alpha amylase catalytic
E4T21_RS04290	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4T21_RS04295	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4T21_RS04295	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4T21_RS04305	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E4T21_RS04310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4T21_RS04320	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4T21_RS04330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4T21_RS04335	COG4143	(ABC) transporter
E4T21_RS04340	COG1178	ABC-type Fe3 transport system permease component
E4T21_RS04350	COG0129	dihydroxy-acid dehydratase activity
E4T21_RS04355	COG0673	inositol 2-dehydrogenase activity
E4T21_RS04360	COG0494	nUDIX hydrolase
E4T21_RS04365	COG1011	Hydrolase
E4T21_RS04370	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E4T21_RS04375	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4T21_RS04385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4T21_RS04390	COG2183	response to ionizing radiation
E4T21_RS04400	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E4T21_RS04410	COG0039	L-malate dehydrogenase activity
E4T21_RS04420	COG0494	nUDIX hydrolase
E4T21_RS04435	COG0745	RESPONSE REGULATOR receiver
E4T21_RS04440	COG0730	response to heat
E4T21_RS04445	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4T21_RS04450	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E4T21_RS04455	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E4T21_RS04480	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E4T21_RS04490	COG2304	oxidoreductase activity
E4T21_RS04495	COG2304	oxidoreductase activity
E4T21_RS04510	COG0714	Associated with various cellular activities
E4T21_RS04520	COG3119	arylsulfatase activity
E4T21_RS04540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T21_RS04545	COG1120	ATPase activity
E4T21_RS04550	COG0477	Major facilitator Superfamily
E4T21_RS04565	COG2831	hemolysin activation secretion protein
E4T21_RS04570	COG3210	domain, Protein
E4T21_RS04610	COG3210	domain, Protein
E4T21_RS04650	COG0659	secondary active sulfate transmembrane transporter activity
E4T21_RS04725	COG0583	DNA-binding transcription factor activity
E4T21_RS04730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4T21_RS04735	COG2813	Specifically methylates the guanine in position
E4T21_RS04745	COG0583	DNA-binding transcription factor activity
E4T21_RS04750	COG1012	belongs to the aldehyde dehydrogenase family
E4T21_RS04755	COG0733	neurotransmitter:sodium symporter activity
E4T21_RS04765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T21_RS04775	COG0494	nUDIX hydrolase
E4T21_RS04785	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E4T21_RS04790	COG0175	sulfate reduction
E4T21_RS04795	COG2895	sulfate adenylyltransferase (ATP) activity
E4T21_RS04805	COG0500	methyltransferase
E4T21_RS04810	COG4106	trans-aconitate 2-methyltransferase activity
E4T21_RS04815	COG0166	Belongs to the GPI family
E4T21_RS04820	COG3150	esterase
E4T21_RS04835	COG3830	Belongs to the UPF0237 family
E4T21_RS04835	COG0560	Phosphoserine phosphatase
E4T21_RS04855	COG1509	lysine 2,3-aminomutase activity
E4T21_RS04860	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4T21_RS04865	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E4T21_RS04870	COG0688	phosphatidylethanolamine metabolic process
E4T21_RS04880	COG1162	GTPase activity
E4T21_RS04895	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4T21_RS04895	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4T21_RS04900	COG0802	atpase or kinase
E4T21_RS04905	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4T21_RS04910	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4T21_RS04915	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4T21_RS04920	COG1923	regulation of RNA biosynthetic process
E4T21_RS04925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4T21_RS04930	COG0330	HflC and HflK could
E4T21_RS04935	COG0330	HflC and HflK could
E4T21_RS04940	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E4T21_RS04945	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E4T21_RS04955	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4T21_RS04960	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4T21_RS04970	COG2329	Antibiotic biosynthesis monooxygenase
E4T21_RS04980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4T21_RS05000	COG2721	sulfolactate sulfo-lyase activity
E4T21_RS05015	COG3386	PFAM SMP-30 Gluconolaconase
E4T21_RS05030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4T21_RS05035	COG3608	succinylglutamate desuccinylase aspartoacylase
E4T21_RS05035	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4T21_RS05050	COG0673	inositol 2-dehydrogenase activity
E4T21_RS05055	COG2814	Major facilitator Superfamily
E4T21_RS05055	COG0477	Major facilitator Superfamily
E4T21_RS05060	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4T21_RS05065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4T21_RS05070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4T21_RS05075	COG0583	DNA-binding transcription factor activity
E4T21_RS05085	COG1902	pentaerythritol trinitrate reductase activity
E4T21_RS05100	COG0583	DNA-binding transcription factor activity
E4T21_RS05120	COG1733	regulation of RNA biosynthetic process
E4T21_RS05145	COG2130	NADP-dependent
E4T21_RS05150	COG1309	transcriptional regulator
E4T21_RS05160	COG0494	nUDIX hydrolase
E4T21_RS05170	COG0596	Alpha beta hydrolase
E4T21_RS05180	COG1473	amidohydrolase
E4T21_RS05190	COG1012	belongs to the aldehyde dehydrogenase family
E4T21_RS05200	COG1234	tRNA 3'-trailer cleavage
E4T21_RS05205	COG3321	synthase
E4T21_RS05205	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS05205	COG0604	alcohol dehydrogenase
E4T21_RS05230	COG4941	Belongs to the sigma-70 factor family
E4T21_RS05250	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4T21_RS05265	COG3243	poly(R)-hydroxyalkanoic acid synthase
E4T21_RS05275	COG4535	Mg2 and Co2 transporter CorC
E4T21_RS05280	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4T21_RS05285	COG1702	phosphate starvation-inducible protein PhoH
E4T21_RS05290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4T21_RS05295	COG4991	sh3 domain protein
E4T21_RS05300	COG0500	methyltransferase
E4T21_RS05310	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4T21_RS05315	COG4208	sulfate ABC transporter
E4T21_RS05335	COG2827	Endonuclease containing a URI domain
E4T21_RS05340	COG0668	transmembrane transport
E4T21_RS05345	COG1252	NADH dehydrogenase
E4T21_RS05360	COG0512	Glutamine amidotransferase of anthranilate synthase
E4T21_RS05365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4T21_RS05375	COG0247	lactate metabolic process
E4T21_RS05375	COG0277	FAD linked oxidase domain protein
E4T21_RS05380	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4T21_RS05390	COG3118	belongs to the thioredoxin family
E4T21_RS05400	COG0175	sulfate reduction
E4T21_RS05415	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E4T21_RS05420	COG0372	Belongs to the citrate synthase family
E4T21_RS05430	COG2828	Protein conserved in bacteria
E4T21_RS05435	COG2079	MmgE PrpD family protein
E4T21_RS05465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4T21_RS05480	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E4T21_RS05490	COG0425	Belongs to the sulfur carrier protein TusA family
E4T21_RS05510	COG3101	peptidyl-lysine hydroxylation
E4T21_RS05525	COG0488	(ABC) transporter
E4T21_RS05530	COG0589	response to stress
E4T21_RS05540	COG1846	Transcriptional regulator
E4T21_RS05555	COG0183	Belongs to the thiolase family
E4T21_RS05565	COG1881	PFAM PEBP family protein
E4T21_RS05570	COG2824	Alkylphosphonate utilization operon protein PhnA
E4T21_RS05585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4T21_RS05600	COG2084	Dehydrogenase
E4T21_RS05610	COG2009	succinate dehydrogenase
E4T21_RS05615	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E4T21_RS05620	COG1053	succinate dehydrogenase
E4T21_RS05645	COG0045	succinate-CoA ligase (ADP-forming) activity
E4T21_RS05660	COG0438	transferase activity, transferring glycosyl groups
E4T21_RS05665	COG0402	S-adenosylhomocysteine deaminase activity
E4T21_RS05680	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4T21_RS05685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4T21_RS05690	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T21_RS05690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4T21_RS05695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4T21_RS05695	COG2190	(PTS) system
E4T21_RS05695	COG1263	PTS System
E4T21_RS05720	COG1653	transport
E4T21_RS05725	COG1175	transmembrane transport
E4T21_RS05730	COG0395	ABC-type sugar transport system, permease component
E4T21_RS05735	COG3842	ATPase activity
E4T21_RS05750	COG3106	COG3106 Predicted ATPase
E4T21_RS05755	COG2814	Major facilitator Superfamily
E4T21_RS05765	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4T21_RS05790	COG0791	NLP P60 protein
E4T21_RS05805	COG2814	Major facilitator Superfamily
E4T21_RS05810	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4T21_RS05820	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4T21_RS05835	COG3133	Outer membrane lipoprotein
E4T21_RS05850	COG2850	peptidyl-arginine hydroxylation
E4T21_RS05860	COG2915	High frequency lysogenization protein hflD homolog
E4T21_RS05865	COG0482	sulfurtransferase activity
E4T21_RS05885	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4T21_RS05890	COG0542	response to heat
E4T21_RS05895	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4T21_RS05900	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E4T21_RS05905	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E4T21_RS05910	COG1674	ftsk spoiiie
E4T21_RS05910	COG1674	ftsk spoiiie
E4T21_RS05915	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4T21_RS05920	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4T21_RS05930	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4T21_RS05935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4T21_RS05940	COG2902	Dehydrogenase
E4T21_RS05945	COG1414	Transcriptional regulator
E4T21_RS05975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T21_RS05980	COG2239	Acts as a magnesium transporter
E4T21_RS05985	COG0167	dihydroorotate dehydrogenase activity
E4T21_RS05990	COG3130	regulation of translation
E4T21_RS05995	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4T21_RS05995	COG0116	Belongs to the methyltransferase superfamily
E4T21_RS06025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4T21_RS06040	COG0501	Belongs to the peptidase M48B family
E4T21_RS06055	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4T21_RS06090	COG1131	(ABC) transporter
E4T21_RS06095	COG0842	Transport permease protein
E4T21_RS06100	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4T21_RS06100	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4T21_RS06105	COG0778	Nitroreductase
E4T21_RS06115	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E4T21_RS06135	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E4T21_RS06150	COG1414	Transcriptional regulator
E4T21_RS06155	COG1024	Enoyl-CoA hydratase
E4T21_RS06165	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS06190	COG2814	Major facilitator Superfamily
E4T21_RS06210	COG3188	usher protein
E4T21_RS06225	COG4770	biotin carboxylase activity
E4T21_RS06230	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E4T21_RS06235	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E4T21_RS06240	COG1914	H( )-stimulated, divalent metal cation uptake system
E4T21_RS06260	COG1999	signal sequence binding
E4T21_RS06270	COG0789	Transcriptional regulator
E4T21_RS06275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T21_RS06280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4T21_RS06290	COG0318	PFAM AMP-dependent synthetase and ligase
E4T21_RS06305	COG0531	amino acid
E4T21_RS06310	COG0531	amino acid
E4T21_RS06365	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS06370	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E4T21_RS06375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4T21_RS06390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T21_RS06395	COG1757	Na H antiporter
E4T21_RS06400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T21_RS06410	COG0583	DNA-binding transcription factor activity
E4T21_RS06420	COG1228	amidohydrolase
E4T21_RS06430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T21_RS06435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS06440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4T21_RS06440	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4T21_RS06445	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4T21_RS06445	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4T21_RS06465	COG1414	Transcriptional regulator
E4T21_RS06485	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E4T21_RS06490	COG2855	membrane
E4T21_RS06495	COG2706	6-phosphogluconolactonase activity
E4T21_RS06515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4T21_RS06520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4T21_RS06530	COG2207	Transcriptional regulator
E4T21_RS06530	COG3708	Transcriptional regulator
E4T21_RS06555	COG2059	Chromate
E4T21_RS06560	COG2059	Chromate
E4T21_RS06565	COG0405	Gamma-glutamyltransferase
E4T21_RS06570	COG1757	Na H antiporter
E4T21_RS06575	COG1802	Transcriptional regulator
E4T21_RS06590	COG0129	dihydroxy-acid dehydratase activity
E4T21_RS06610	COG4948	Mandelate Racemase Muconate Lactonizing
E4T21_RS06615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4T21_RS06625	COG1304	FMN binding
E4T21_RS06650	COG0433	COG0433 Predicted ATPase
E4T21_RS06660	COG1192	Involved in chromosome partitioning
E4T21_RS06680	COG4575	ribosome binding
E4T21_RS06690	COG3264	Mechanosensitive ion channel
E4T21_RS06690	COG1196	nuclear chromosome segregation
E4T21_RS06695	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E4T21_RS06715	COG3608	succinylglutamate desuccinylase aspartoacylase
E4T21_RS06715	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4T21_RS06735	COG0659	secondary active sulfate transmembrane transporter activity
E4T21_RS06750	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4T21_RS06755	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4T21_RS06760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4T21_RS06770	COG3100	YcgL domain-containing protein
E4T21_RS06775	COG2983	Belongs to the UPF0260 family
E4T21_RS06790	COG0523	cobalamin synthesis protein
E4T21_RS06800	COG0154	amidase activity
E4T21_RS06825	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS06830	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS06835	COG0583	DNA-binding transcription factor activity
E4T21_RS06840	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E4T21_RS06850	COG0439	Biotin carboxylase
E4T21_RS06860	COG1984	allophanate hydrolase subunit 2
E4T21_RS06895	COG0121	glutamine amidotransferase
E4T21_RS06900	COG0318	PFAM AMP-dependent synthetase and ligase
E4T21_RS06905	COG1643	Atp-dependent helicase
E4T21_RS06915	COG2853	Lipoprotein
E4T21_RS06930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4T21_RS06935	COG2814	Major facilitator Superfamily
E4T21_RS06950	COG0573	inorganic phosphate transmembrane transporter activity
E4T21_RS06960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4T21_RS06965	COG0183	Belongs to the thiolase family
E4T21_RS06970	COG1309	transcriptional regulator
E4T21_RS06975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4T21_RS06985	COG1960	acyl-CoA dehydrogenase activity
E4T21_RS06990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4T21_RS07005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4T21_RS07005	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4T21_RS07015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T21_RS07020	COG1660	Displays ATPase and GTPase activities
E4T21_RS07035	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4T21_RS07040	COG1137	ATPase activity
E4T21_RS07045	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E4T21_RS07055	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4T21_RS07065	COG1127	ABC transporter
E4T21_RS07070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4T21_RS07075	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4T21_RS07090	COG0271	Belongs to the BolA IbaG family
E4T21_RS07100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E4T21_RS07110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4T21_RS07125	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4T21_RS07130	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4T21_RS07140	COG0723	plastoquinol--plastocyanin reductase activity
E4T21_RS07145	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E4T21_RS07150	COG2857	Cytochrome c1
E4T21_RS07155	COG0625	glutathione transferase activity
E4T21_RS07160	COG2969	positive regulation of protein catabolic process
E4T21_RS07165	COG2823	Periplasmic or secreted lipoprotein
E4T21_RS07175	COG0792	nuclease activity
E4T21_RS07180	COG3107	peptidoglycan biosynthetic process
E4T21_RS07195	COG0275	rRNA processing
E4T21_RS07200	COG3116	cell division
E4T21_RS07210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4T21_RS07215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4T21_RS07220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4T21_RS07225	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4T21_RS07230	COG0772	Belongs to the SEDS family
E4T21_RS07235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4T21_RS07240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4T21_RS07245	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4T21_RS07265	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E4T21_RS07280	COG0653	protein targeting
E4T21_RS07290	COG0352	thiamine-phosphate diphosphorylase activity
E4T21_RS07295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4T21_RS07300	COG2957	Belongs to the agmatine deiminase family
E4T21_RS07305	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4T21_RS07310	COG1136	(ABC) transporter
E4T21_RS07325	COG1132	(ABC) transporter
E4T21_RS07335	COG2835	tetraacyldisaccharide 4'-kinase activity
E4T21_RS07340	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E4T21_RS07345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4T21_RS07350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4T21_RS07355	COG1530	ribonuclease E activity
E4T21_RS07360	COG0564	pseudouridine synthase activity
E4T21_RS07385	COG0424	maF-like protein
E4T21_RS07395	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4T21_RS07400	COG0416	fatty acid biosynthetic process
E4T21_RS07405	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4T21_RS07415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4T21_RS07420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4T21_RS07425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4T21_RS07430	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4T21_RS07435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4T21_RS07445	COG0084	hydrolase, TatD family'
E4T21_RS07465	COG1301	dicarboxylic acid transport
E4T21_RS07490	COG0811	peptide transport
E4T21_RS07495	COG0811	peptide transport
E4T21_RS07500	COG0848	biopolymer transport protein
E4T21_RS07525	COG0513	Belongs to the DEAD box helicase family
E4T21_RS07530	COG1199	ATP-dependent helicase activity
E4T21_RS07535	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4T21_RS07555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4T21_RS07560	COG0481	GTPase activity
E4T21_RS07565	COG0681	Belongs to the peptidase S26 family
E4T21_RS07570	COG0571	ribonuclease III activity
E4T21_RS07580	COG1381	Involved in DNA repair and RecF pathway recombination
E4T21_RS07605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4T21_RS07610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4T21_RS07615	COG3956	TIGRFAM MazG family protein
E4T21_RS07620	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E4T21_RS07635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4T21_RS07640	COG0653	protein targeting
E4T21_RS07655	COG1047	Peptidyl-prolyl cis-trans
E4T21_RS07660	COG0442	prolyl-tRNA aminoacylation
E4T21_RS07665	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4T21_RS07680	COG2084	Dehydrogenase
E4T21_RS07710	COG1797	cobyrinic acid a,c-diamide synthase activity
E4T21_RS07745	COG2099	Precorrin-6x reductase
E4T21_RS07760	COG2875	Belongs to the precorrin methyltransferase family
E4T21_RS07770	COG1280	lysine exporter protein (LysE YggA)
E4T21_RS07780	COG0417	DNA replication proofreading
E4T21_RS07785	COG3081	Nucleoid-associated protein
E4T21_RS07790	COG0842	Transport permease protein
E4T21_RS07795	COG1131	(ABC) transporter
E4T21_RS07805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4T21_RS07815	COG1683	Conserved Protein
E4T21_RS07835	COG1566	PFAM secretion protein HlyD family protein
E4T21_RS07870	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4T21_RS07875	COG2226	methyltransferase
E4T21_RS07885	COG0156	8-amino-7-oxononanoate synthase activity
E4T21_RS07890	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4T21_RS07895	COG1040	competence protein
E4T21_RS07905	COG0302	gtp cyclohydrolase
E4T21_RS07910	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4T21_RS07915	COG1012	belongs to the aldehyde dehydrogenase family
E4T21_RS07920	COG0138	bifunctional purine biosynthesis protein purh
E4T21_RS07935	COG2264	protein methyltransferase activity
E4T21_RS07945	COG0511	ligase activity, forming carbon-carbon bonds
E4T21_RS07960	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4T21_RS07980	COG0205	6-phosphofructokinase activity
E4T21_RS07985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4T21_RS07995	COG1280	lysine exporter protein (LysE YggA)
E4T21_RS08000	COG0586	Pfam SNARE associated Golgi protein
E4T21_RS08015	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E4T21_RS08020	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E4T21_RS08030	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E4T21_RS08035	COG0768	penicillin binding
E4T21_RS08040	COG0772	Belongs to the SEDS family
E4T21_RS08045	COG2951	lytic endotransglycosylase activity
E4T21_RS08055	COG1686	Belongs to the peptidase S11 family
E4T21_RS08060	COG2921	Belongs to the UPF0250 family
E4T21_RS08065	COG0321	lipoyl(octanoyl) transferase activity
E4T21_RS08070	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4T21_RS08100	COG1376	ErfK ybiS ycfS ynhG family protein
E4T21_RS08105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4T21_RS08115	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4T21_RS08120	COG1805	sodium ion transport
E4T21_RS08135	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4T21_RS08140	COG2871	sodium ion transport
E4T21_RS08150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4T21_RS08155	COG3189	MarR family transcriptional regulator
E4T21_RS08300	COG3789	protein conserved in bacteria
E4T21_RS08305	COG1842	Phage shock protein A
E4T21_RS08310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4T21_RS08320	COG3766	membrane
E4T21_RS08330	COG0754	glutathionylspermidine amidase activity
E4T21_RS08335	COG2321	neutral zinc metallopeptidase
E4T21_RS08350	COG0495	leucyl-tRNA aminoacylation
E4T21_RS08370	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E4T21_RS08375	COG0066	3-isopropylmalate dehydratase activity
E4T21_RS08380	COG0473	3-isopropylmalate dehydrogenase activity
E4T21_RS08395	COG0135	phosphoribosylanthranilate isomerase activity
E4T21_RS08400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4T21_RS08405	COG0285	dihydrofolate synthase activity
E4T21_RS08430	COG3038	cytochrome b561
E4T21_RS08435	COG2353	YceI-like domain
E4T21_RS08440	COG0534	Mate efflux family protein
E4T21_RS08445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T21_RS08450	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4T21_RS08460	COG2181	nitrate reductase activity
E4T21_RS08465	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E4T21_RS08470	COG1140	nitrate reductase beta subunit
E4T21_RS08475	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E4T21_RS08480	COG2223	nitrite transmembrane transporter activity
E4T21_RS08485	COG3850	Histidine kinase
E4T21_RS08490	COG2197	response regulator
E4T21_RS08500	COG2154	pterin-4-alpha-carbinolamine dehydratase
E4T21_RS08515	COG0514	ATP-dependent DNA helicase (RecQ)
E4T21_RS08535	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4T21_RS08540	COG0011	TIGRFAM Protein of
E4T21_RS08545	COG0583	DNA-binding transcription factor activity
E4T21_RS08560	COG0733	neurotransmitter:sodium symporter activity
E4T21_RS08565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4T21_RS08565	COG1648	precorrin-2 dehydrogenase activity
E4T21_RS08570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4T21_RS08590	COG1414	Transcriptional regulator
E4T21_RS08635	COG0829	nickel cation binding
E4T21_RS08640	COG0831	urea catabolic process
E4T21_RS08645	COG0832	Belongs to the urease beta subunit family
E4T21_RS08650	COG0804	urea catabolic process
E4T21_RS08655	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
E4T21_RS08660	COG0830	nickel cation binding
E4T21_RS08665	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4T21_RS08690	COG0489	protein tyrosine kinase activity
E4T21_RS08695	COG0717	Belongs to the dCTP deaminase family
E4T21_RS08700	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4T21_RS08705	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4T21_RS08710	COG0628	permease
E4T21_RS08735	COG2197	response regulator
E4T21_RS08740	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4T21_RS08745	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4T21_RS08750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4T21_RS08755	COG0137	argininosuccinate synthase activity
E4T21_RS08785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4T21_RS08790	COG2878	Part of a membrane complex involved in electron transport
E4T21_RS08795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4T21_RS08795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4T21_RS08800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4T21_RS08800	COG0301	tRNA thio-modification
E4T21_RS08810	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4T21_RS08815	COG1854	S-ribosylhomocysteine lyase activity
E4T21_RS08820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4T21_RS08845	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4T21_RS08850	COG0740	serine-type endopeptidase activity
E4T21_RS08855	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4T21_RS08860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4T21_RS08870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4T21_RS08875	COG0523	cobalamin synthesis protein
E4T21_RS08880	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4T21_RS08885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4T21_RS08890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4T21_RS08895	COG0215	cysteine-tRNA ligase activity
E4T21_RS08905	COG1732	Glycine betaine
E4T21_RS08910	COG1174	glycine betaine transport
E4T21_RS08915	COG1125	glycine betaine transport
E4T21_RS08920	COG1174	glycine betaine transport
E4T21_RS08930	COG0022	dehydrogenase e1 component
E4T21_RS08945	COG1802	Transcriptional regulator
E4T21_RS08960	COG2962	Rard protein
E4T21_RS08970	COG1187	pseudouridine synthase activity
E4T21_RS08975	COG3706	GGDEF domain
E4T21_RS08980	COG4172	Belongs to the ABC transporter superfamily
E4T21_RS08985	COG4239	(ABC) transporter, permease
E4T21_RS08990	COG4174	ABC transporter (Permease)
E4T21_RS08995	COG4166	transmembrane transport
E4T21_RS09000	COG0741	lytic transglycosylase activity
E4T21_RS09000	COG1388	LysM domain
E4T21_RS09005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4T21_RS09015	COG0328	RNA-DNA hybrid ribonuclease activity
E4T21_RS09020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4T21_RS09025	COG2816	NAD+ diphosphatase activity
E4T21_RS09035	COG0616	signal peptide processing
E4T21_RS09040	COG0640	Transcriptional regulator
E4T21_RS09045	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E4T21_RS09060	COG3263	regulation of cellular component size
E4T21_RS09065	COG3042	response to heat
E4T21_RS09080	COG0778	Nitroreductase
E4T21_RS09095	COG3273	potassium ion transport
E4T21_RS09095	COG0471	metal ion transport
E4T21_RS09160	COG0625	glutathione transferase activity
E4T21_RS09200	COG0189	ligase activity
E4T21_RS09200	COG4067	protein conserved in archaea
E4T21_RS09205	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
E4T21_RS09215	COG1376	ErfK ybiS ycfS ynhG family protein
E4T21_RS09220	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4T21_RS09230	COG1063	alcohol dehydrogenase
E4T21_RS09255	COG1733	regulation of RNA biosynthetic process
E4T21_RS09265	COG2814	Major facilitator Superfamily
E4T21_RS09270	COG0583	DNA-binding transcription factor activity
E4T21_RS09355	COG4774	siderophore transport
E4T21_RS09365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4T21_RS09370	COG0670	Belongs to the BI1 family
E4T21_RS09400	COG0303	'Molybdopterin
E4T21_RS09405	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4T21_RS09420	COG0437	4 iron, 4 sulfur cluster binding
E4T21_RS09425	COG3383	formate dehydrogenase (NAD+) activity
E4T21_RS09425	COG0243	molybdopterin cofactor binding
E4T21_RS09445	COG0596	Alpha beta hydrolase
E4T21_RS09460	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4T21_RS09470	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4T21_RS09480	COG0259	pyridoxamine-phosphate oxidase activity
E4T21_RS09500	COG2840	Smr protein MutS2
E4T21_RS09515	COG2207	Transcriptional regulator
E4T21_RS09525	COG2015	COG2015, Alkyl sulfatase and related hydrolases
E4T21_RS09535	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4T21_RS09540	COG0534	Mate efflux family protein
E4T21_RS09550	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4T21_RS09550	COG0316	Belongs to the HesB IscA family
E4T21_RS09570	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS09575	COG1063	alcohol dehydrogenase
E4T21_RS09580	COG4948	Mandelate Racemase Muconate Lactonizing
E4T21_RS09585	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4T21_RS09590	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4T21_RS09595	COG1129	ABC transporter
E4T21_RS09600	COG1879	ABC-type sugar transport system periplasmic component
E4T21_RS09605	COG1012	belongs to the aldehyde dehydrogenase family
E4T21_RS09620	COG1309	transcriptional regulator
E4T21_RS09625	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS09630	COG1960	acyl-CoA dehydrogenase activity
E4T21_RS09640	COG0318	PFAM AMP-dependent synthetase and ligase
E4T21_RS09665	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4T21_RS09670	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E4T21_RS09675	COG0735	belongs to the Fur family
E4T21_RS09690	COG4067	protein conserved in archaea
E4T21_RS09690	COG0189	ligase activity
E4T21_RS09715	COG1757	Na H antiporter
E4T21_RS09730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4T21_RS09755	COG2885	chlorophyll binding
E4T21_RS09770	COG2226	methyltransferase
E4T21_RS09780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4T21_RS09790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4T21_RS09795	COG4115	mRNA cleavage
E4T21_RS09800	COG2161	toxin-antitoxin pair type II binding
E4T21_RS09805	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4T21_RS09810	COG0531	amino acid
E4T21_RS09825	COG0583	DNA-binding transcription factor activity
E4T21_RS09840	COG2223	nitrite transmembrane transporter activity
E4T21_RS09850	COG2186	Transcriptional regulator
E4T21_RS09855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4T21_RS09870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS09875	COG1917	Cupin 2, conserved barrel domain protein
E4T21_RS09880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4T21_RS09885	COG0456	acetyltransferase
E4T21_RS09895	COG0288	reversible hydration of carbon dioxide
E4T21_RS09905	COG0601	transmembrane transport
E4T21_RS09910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4T21_RS09920	COG4608	Belongs to the ABC transporter superfamily
E4T21_RS09935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4T21_RS09940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4T21_RS09960	COG3246	L-lysine catabolic process to acetate
E4T21_RS09985	COG1012	belongs to the aldehyde dehydrogenase family
E4T21_RS09995	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS10000	COG3618	amidohydrolase
E4T21_RS10005	COG3254	rhamnose metabolic process
E4T21_RS10010	COG4948	Mandelate Racemase Muconate Lactonizing
E4T21_RS10020	COG2911	Protein conserved in bacteria
E4T21_RS10045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4T21_RS10060	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS10070	COG2885	chlorophyll binding
E4T21_RS10095	COG2255	four-way junction helicase activity
E4T21_RS10100	COG0632	four-way junction helicase activity
E4T21_RS10105	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4T21_RS10115	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4T21_RS10125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4T21_RS10140	COG1254	Belongs to the acylphosphatase family
E4T21_RS10145	COG1295	ribonuclease BN
E4T21_RS10150	COG1051	belongs to the nudix hydrolase family
E4T21_RS10150	COG1056	cytidyltransferase-related domain
E4T21_RS10155	COG0583	DNA-binding transcription factor activity
E4T21_RS10160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4T21_RS10170	COG0556	nucleotide-excision repair
E4T21_RS10190	COG0084	hydrolase, TatD family'
E4T21_RS10195	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E4T21_RS10215	COG2205	protein histidine kinase activity
E4T21_RS10220	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E4T21_RS10225	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS10230	COG0483	inositol monophosphate 1-phosphatase activity
E4T21_RS10235	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4T21_RS10250	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E4T21_RS10255	COG0583	DNA-binding transcription factor activity
E4T21_RS10260	COG0204	Acyl-transferase
E4T21_RS10265	COG1388	LysM domain
E4T21_RS10265	COG3942	CHAP domain
E4T21_RS10275	COG0671	phosphoesterase, PA-phosphatase related
E4T21_RS10285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4T21_RS10290	COG1115	amino acid carrier protein
E4T21_RS10295	COG0509	glycine decarboxylation via glycine cleavage system
E4T21_RS10300	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4T21_RS10300	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4T21_RS10305	COG0583	DNA-binding transcription factor activity
E4T21_RS10315	COG1611	Belongs to the LOG family
E4T21_RS10330	COG0776	regulation of translation
E4T21_RS10335	COG0072	phenylalanine-tRNA ligase activity
E4T21_RS10340	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E4T21_RS10345	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4T21_RS10350	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4T21_RS10355	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E4T21_RS10360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4T21_RS10365	COG2885	chlorophyll binding
E4T21_RS10375	COG0109	protoheme IX farnesyltransferase activity
E4T21_RS10380	COG1612	heme a metabolic process
E4T21_RS10405	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E4T21_RS10410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4T21_RS10415	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4T21_RS10425	COG1346	cytolysis
E4T21_RS10430	COG1380	Effector of murein hydrolase LrgA
E4T21_RS10490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4T21_RS10505	COG1309	transcriptional regulator
E4T21_RS10515	COG2985	domain, Protein
E4T21_RS10545	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
E4T21_RS10570	COG0024	Methionine aminopeptidase
E4T21_RS10575	COG3314	Sporulation integral membrane protein YlbJ
E4T21_RS10580	COG1228	amidohydrolase
E4T21_RS10585	COG0010	Belongs to the arginase family
E4T21_RS10595	COG2986	histidine ammonia-lyase
E4T21_RS10600	COG2056	Na+-H+ antiporter family
E4T21_RS10610	COG2066	Belongs to the glutaminase family
E4T21_RS10615	COG1643	Atp-dependent helicase
E4T21_RS10620	COG2252	PERMEase
E4T21_RS10625	COG1309	transcriptional regulator
E4T21_RS10635	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4T21_RS10645	COG0402	S-adenosylhomocysteine deaminase activity
E4T21_RS10650	COG3338	carbonate dehydratase activity
E4T21_RS10690	COG3210	domain, Protein
E4T21_RS10690	COG3210	domain, Protein
E4T21_RS10695	COG2831	hemolysin activation secretion protein
E4T21_RS10700	COG1054	Belongs to the UPF0176 family
E4T21_RS10705	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4T21_RS10710	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4T21_RS10715	COG4988	ABC transporter
E4T21_RS10720	COG1294	oxidase, subunit
E4T21_RS10725	COG1271	oxidase subunit
E4T21_RS10735	COG2995	paraquat-inducible protein a
E4T21_RS10740	COG3008	intermembrane lipid transfer
E4T21_RS10740	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4T21_RS10750	COG0513	Belongs to the DEAD box helicase family
E4T21_RS10760	COG2807	transmembrane transport
E4T21_RS10765	COG0252	asparaginase activity
E4T21_RS10780	COG0826	peptidase U32
E4T21_RS10785	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E4T21_RS10790	COG0602	queuosine metabolic process
E4T21_RS10825	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E4T21_RS10830	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E4T21_RS10840	COG2207	Transcriptional regulator
E4T21_RS10845	COG1064	alcohol dehydrogenase
E4T21_RS10850	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4T21_RS10855	COG0584	glycerophosphoryl diester phosphodiesterase
E4T21_RS10860	COG0405	Gamma-glutamyltransferase
E4T21_RS10870	COG2261	transglycosylase associated protein
E4T21_RS10890	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E4T21_RS10920	COG1960	acyl-CoA dehydrogenase activity
E4T21_RS10930	COG1024	Enoyl-CoA hydratase
E4T21_RS10930	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4T21_RS10935	COG1960	acyl-CoA dehydrogenase activity
E4T21_RS10940	COG0789	Transcriptional regulator
E4T21_RS10945	COG0318	PFAM AMP-dependent synthetase and ligase
E4T21_RS10950	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E4T21_RS10960	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E4T21_RS10965	COG0237	dephospho-CoA kinase activity
E4T21_RS10970	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E4T21_RS10995	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E4T21_RS11000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4T21_RS11005	COG1605	Chorismate mutase
E4T21_RS11005	COG0077	Prephenate dehydratase
E4T21_RS11010	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E4T21_RS11020	COG0824	Thioesterase
E4T21_RS11025	COG2974	May be involved in recombination
E4T21_RS11035	COG0418	dihydroorotase activity
E4T21_RS11045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T21_RS11080	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4T21_RS11095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4T21_RS11130	COG1129	ABC transporter
E4T21_RS11155	COG0129	dihydroxy-acid dehydratase activity
E4T21_RS11165	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E4T21_RS11170	COG2211	Major facilitator Superfamily
E4T21_RS11175	COG3940	Belongs to the glycosyl hydrolase 43 family
E4T21_RS11190	COG0583	DNA-binding transcription factor activity
E4T21_RS11195	COG4948	Mandelate Racemase Muconate Lactonizing
E4T21_RS11200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS11215	COG0277	FAD linked oxidase domain protein
E4T21_RS11225	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS11230	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4T21_RS11235	COG1063	alcohol dehydrogenase
E4T21_RS11240	COG2721	sulfolactate sulfo-lyase activity
E4T21_RS11245	COG0246	Mannitol dehydrogenase
E4T21_RS11250	COG2186	Transcriptional regulator
E4T21_RS11255	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E4T21_RS11260	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4T21_RS11265	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4T21_RS11270	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS11285	COG0322	excinuclease ABC activity
E4T21_RS11345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4T21_RS11355	COG1121	(ABC) transporter
E4T21_RS11360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4T21_RS11375	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4T21_RS11395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4T21_RS11405	COG0315	cyclic pyranopterin monophosphate synthase activity
E4T21_RS11410	COG0303	'Molybdopterin
E4T21_RS11415	COG1763	Mo-molybdopterin cofactor biosynthetic process
E4T21_RS11420	COG0746	molybdenum cofactor guanylyltransferase activity
E4T21_RS11445	COG0395	ABC-type sugar transport system, permease component
E4T21_RS11455	COG3842	ATPase activity
E4T21_RS11465	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4T21_RS11470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E4T21_RS11475	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E4T21_RS11480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4T21_RS11485	COG2252	PERMEase
E4T21_RS11490	COG0307	riboflavin synthase, alpha
E4T21_RS11495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4T21_RS11500	COG2011	ABC-type metal ion transport system permease component
E4T21_RS11505	COG1464	Belongs to the NlpA lipoprotein family
E4T21_RS11510	COG1956	GAF domain-containing protein
E4T21_RS11530	COG1349	DNA-binding transcription factor activity
E4T21_RS11535	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4T21_RS11545	COG1012	belongs to the aldehyde dehydrogenase family
E4T21_RS11580	COG1942	4-Oxalocrotonate Tautomerase
E4T21_RS11590	COG2207	Transcriptional regulator
E4T21_RS11595	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS11635	COG3501	Rhs element vgr protein
E4T21_RS11635	COG3409	Peptidoglycan-binding domain 1 protein
E4T21_RS11690	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4T21_RS11695	COG0174	glutamine synthetase
E4T21_RS11700	COG1757	Na H antiporter
E4T21_RS11710	COG4953	penicillin-binding protein 1C
E4T21_RS11715	COG2373	Large extracellular alpha-helical protein
E4T21_RS11720	COG3134	Outer membrane lipoprotein
E4T21_RS11745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4T21_RS11755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T21_RS11770	COG1177	transmembrane transport
E4T21_RS11775	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4T21_RS11780	COG3842	ATPase activity
E4T21_RS11785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T21_RS11795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4T21_RS11805	COG2890	protein-(glutamine-N5) methyltransferase activity
E4T21_RS11810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4T21_RS11815	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4T21_RS11825	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E4T21_RS11830	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4T21_RS11840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4T21_RS11845	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4T21_RS11850	COG0193	aminoacyl-tRNA hydrolase activity
E4T21_RS11920	COG0438	transferase activity, transferring glycosyl groups
E4T21_RS11945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4T21_RS11950	COG1215	transferase activity, transferring glycosyl groups
E4T21_RS11995	COG2895	sulfate adenylyltransferase (ATP) activity
E4T21_RS12005	COG0175	sulfate reduction
E4T21_RS12010	COG0471	metal ion transport
E4T21_RS12010	COG3273	potassium ion transport
E4T21_RS12025	COG1459	type II secretion system
E4T21_RS12035	COG1309	transcriptional regulator
E4T21_RS12040	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4T21_RS12045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4T21_RS12060	COG0776	regulation of translation
E4T21_RS12070	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E4T21_RS12075	COG0284	orotidine-5'-phosphate decarboxylase activity
E4T21_RS12080	COG1596	polysaccharide export
E4T21_RS12080	COG1555	photosystem II stabilization
E4T21_RS12085	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS12095	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4T21_RS12100	COG0459	protein refolding
E4T21_RS12110	COG2056	Na+-H+ antiporter family
E4T21_RS12145	COG1960	acyl-CoA dehydrogenase activity
E4T21_RS12150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4T21_RS12180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T21_RS12185	COG0312	modulator of DNA gyrase
E4T21_RS12190	COG3028	Belongs to the UPF0307 family
E4T21_RS12195	COG0312	modulator of DNA gyrase
E4T21_RS12205	COG1530	ribonuclease E activity
E4T21_RS12210	COG0424	maF-like protein
E4T21_RS12215	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E4T21_RS12220	COG1792	Involved in formation and maintenance of cell shape
E4T21_RS12225	COG1077	Cell shape determining protein MreB Mrl
E4T21_RS12230	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4T21_RS12235	COG0154	amidase activity
E4T21_RS12240	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4T21_RS12250	COG4977	sequence-specific DNA binding
E4T21_RS12265	COG0793	Belongs to the peptidase S41A family
E4T21_RS12270	COG0604	alcohol dehydrogenase
E4T21_RS12270	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS12270	COG3321	synthase
E4T21_RS12275	COG3938	Belongs to the proline racemase family
E4T21_RS12290	COG3320	Male sterility
E4T21_RS12290	COG1022	Amp-dependent synthetase and ligase
E4T21_RS12310	COG1846	Transcriptional regulator
E4T21_RS12315	COG1024	Enoyl-CoA hydratase
E4T21_RS12320	COG1012	belongs to the aldehyde dehydrogenase family
E4T21_RS12325	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS12330	COG0583	DNA-binding transcription factor activity
E4T21_RS12340	COG3938	Belongs to the proline racemase family
E4T21_RS12345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4T21_RS12365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T21_RS12370	COG1757	Na H antiporter
E4T21_RS12380	COG3239	Fatty acid desaturase
E4T21_RS12390	COG3459	Glycosyltransferase 36 associated
E4T21_RS12405	COG1469	GTP cyclohydrolase I activity
E4T21_RS12415	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4T21_RS12425	COG0523	cobalamin synthesis protein
E4T21_RS12450	COG3443	Belongs to the bacterial solute-binding protein 9 family
E4T21_RS12455	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E4T21_RS12460	COG0596	Alpha beta hydrolase
E4T21_RS12460	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4T21_RS12460	COG2226	methyltransferase
E4T21_RS12540	COG1335	isochorismatase
E4T21_RS12545	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E4T21_RS12555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4T21_RS12560	COG0747	negative chemotaxis
E4T21_RS12575	COG0444	Belongs to the ABC transporter superfamily
E4T21_RS12610	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E4T21_RS12640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T21_RS12645	COG0471	metal ion transport
E4T21_RS12645	COG3273	potassium ion transport
E4T21_RS12655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4T21_RS12665	COG1280	lysine exporter protein (LysE YggA)
E4T21_RS12685	COG0584	glycerophosphoryl diester phosphodiesterase
E4T21_RS12690	COG1492	cobalamin metabolic process
E4T21_RS12700	COG1120	ATPase activity
E4T21_RS12705	COG4139	cobalamin transport
E4T21_RS12710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4T21_RS12715	COG4206	TonB-dependent receptor
E4T21_RS12730	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E4T21_RS12740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4T21_RS12745	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E4T21_RS12750	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E4T21_RS12775	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4T21_RS12780	COG3383	formate dehydrogenase (NAD+) activity
E4T21_RS12795	COG2005	Transcriptional regulator
E4T21_RS12800	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS12810	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4T21_RS12810	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4T21_RS12815	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS12825	COG3246	L-lysine catabolic process to acetate
E4T21_RS12830	COG1609	Transcriptional regulator
E4T21_RS12835	COG0625	glutathione transferase activity
E4T21_RS12850	COG0786	glutamate:sodium symporter activity
E4T21_RS12855	COG0010	Belongs to the arginase family
E4T21_RS12880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4T21_RS12885	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4T21_RS12890	COG0697	spore germination
E4T21_RS12900	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E4T21_RS12900	COG0517	IMP dehydrogenase activity
E4T21_RS12900	COG0617	tRNA 3'-terminal CCA addition
E4T21_RS12925	COG0583	DNA-binding transcription factor activity
E4T21_RS12960	COG1024	Enoyl-CoA hydratase
E4T21_RS13005	COG2084	Dehydrogenase
E4T21_RS13015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T21_RS13040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4T21_RS13055	COG3047	cAMP biosynthetic process
E4T21_RS13060	COG3047	cAMP biosynthetic process
E4T21_RS13070	COG3098	single-species biofilm formation
E4T21_RS13075	COG1126	abc transporter atp-binding protein
E4T21_RS13095	COG0189	ligase activity
E4T21_RS13095	COG4067	protein conserved in archaea
E4T21_RS13100	COG0189	ligase activity
E4T21_RS13110	COG2949	membrane
E4T21_RS13120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4T21_RS13125	COG0719	Fe-S assembly protein
E4T21_RS13130	COG0396	ATPase activity
E4T21_RS13135	COG0719	Fe-S assembly protein
E4T21_RS13140	COG1959	2 iron, 2 sulfur cluster binding
E4T21_RS13165	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS13170	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4T21_RS13175	COG3265	gluconokinase activity
E4T21_RS13180	COG3734	2-keto-3-deoxy-galactonokinase
E4T21_RS13185	COG0800	Aldolase
E4T21_RS13190	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4T21_RS13200	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E4T21_RS13235	COG1115	amino acid carrier protein
E4T21_RS13255	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E4T21_RS13260	COG1737	Transcriptional regulator
E4T21_RS13270	COG1971	Probably functions as a manganese efflux pump
E4T21_RS13280	COG0583	DNA-binding transcription factor activity
E4T21_RS13290	COG0477	Major facilitator Superfamily
E4T21_RS13305	COG2186	Transcriptional regulator
E4T21_RS13310	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS13320	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4T21_RS13320	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4T21_RS13330	COG4948	Mandelate Racemase Muconate Lactonizing
E4T21_RS13340	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS13350	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS13355	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4T21_RS13360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4T21_RS13380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4T21_RS13410	COG0583	DNA-binding transcription factor activity
E4T21_RS13420	COG0583	DNA-binding transcription factor activity
E4T21_RS13425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4T21_RS13455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T21_RS13460	COG1538	Outer membrane efflux protein
E4T21_RS13470	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4T21_RS13495	COG4566	intracellular signal transduction
E4T21_RS13510	COG1794	racemase activity, acting on amino acids and derivatives
E4T21_RS13525	COG1024	Enoyl-CoA hydratase
E4T21_RS13530	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4T21_RS13535	COG0318	PFAM AMP-dependent synthetase and ligase
E4T21_RS13540	COG1960	acyl-CoA dehydrogenase activity
E4T21_RS13570	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
E4T21_RS13575	COG2943	transferase activity, transferring hexosyl groups
E4T21_RS13590	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4T21_RS13635	COG0109	protoheme IX farnesyltransferase activity
E4T21_RS13640	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4T21_RS13645	COG1845	cytochrome c oxidase, subunit III
E4T21_RS13650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4T21_RS13655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4T21_RS13670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4T21_RS13675	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4T21_RS13680	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E4T21_RS13690	COG0813	purine-nucleoside phosphorylase activity
E4T21_RS13695	COG0295	cytidine deaminase activity
E4T21_RS13700	COG0668	transmembrane transport
E4T21_RS13705	COG0656	L-ascorbic acid biosynthetic process
E4T21_RS13715	COG1515	deoxyribonuclease V activity
E4T21_RS13720	COG0420	3'-5' exonuclease activity
E4T21_RS13730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4T21_RS13735	COG0519	Catalyzes the synthesis of GMP from XMP
E4T21_RS13735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4T21_RS13740	COG0840	transmembrane signaling receptor activity
E4T21_RS13750	COG1671	Belongs to the UPF0178 family
E4T21_RS13755	COG0435	Glutathione S-transferase
E4T21_RS13760	COG0583	DNA-binding transcription factor activity
E4T21_RS13765	COG0739	heme binding
E4T21_RS13770	COG3284	Transcriptional regulator
E4T21_RS13780	COG2963	transposase activity
E4T21_RS13795	COG1609	Transcriptional regulator
E4T21_RS13800	COG0673	inositol 2-dehydrogenase activity
E4T21_RS13810	COG2211	Major facilitator Superfamily
E4T21_RS13815	COG2989	Protein conserved in bacteria
E4T21_RS13840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4T21_RS13850	COG0243	molybdopterin cofactor binding
E4T21_RS13855	COG3707	response regulator
E4T21_RS13860	COG1116	anion transmembrane transporter activity
E4T21_RS13860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4T21_RS13865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4T21_RS13870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4T21_RS13870	COG2146	nitrite reductase [NAD(P)H] activity
E4T21_RS13875	COG2146	nitrite reductase [NAD(P)H] activity
E4T21_RS13875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4T21_RS13880	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E4T21_RS13900	COG1278	Cold shock
E4T21_RS13905	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E4T21_RS13920	COG0069	glutamate synthase activity
E4T21_RS13930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4T21_RS13955	COG0159	tryptophan synthase activity
E4T21_RS13960	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4T21_RS13965	COG0326	Molecular chaperone. Has ATPase activity
E4T21_RS13970	COG3339	Conserved Protein
E4T21_RS13975	COG0741	lytic transglycosylase activity
E4T21_RS13980	COG1280	lysine exporter protein (LysE YggA)
E4T21_RS13990	COG1278	Cold shock
E4T21_RS14005	COG1597	lipid kinase activity
E4T21_RS14010	COG0475	glutathione-regulated potassium exporter activity
E4T21_RS14020	COG0308	aminopeptidase N
E4T21_RS14030	COG1666	GTP binding
E4T21_RS14040	COG0189	ligase activity
E4T21_RS14045	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E4T21_RS14050	COG3667	copper resistance
E4T21_RS14060	COG3850	Histidine kinase
E4T21_RS14060	COG5002	protein histidine kinase activity
E4T21_RS14075	COG0583	DNA-binding transcription factor activity
E4T21_RS14115	COG1136	(ABC) transporter
E4T21_RS14125	COG1566	PFAM secretion protein HlyD family protein
E4T21_RS14140	COG0583	DNA-binding transcription factor activity
E4T21_RS14145	COG3119	arylsulfatase activity
E4T21_RS14155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4T21_RS14160	COG0667	Aldo Keto reductase
E4T21_RS14165	COG0330	HflC and HflK could
E4T21_RS14170	COG1030	water channel activity
E4T21_RS14175	COG0765	amino acid transport
E4T21_RS14185	COG0765	amino acid transport
E4T21_RS14205	COG0456	acetyltransferase
E4T21_RS14235	COG4789	Type iii secretion
E4T21_RS14240	COG4964	Belongs to the GSP D family
E4T21_RS14295	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4T21_RS14300	COG4790	Type iii secretion
E4T21_RS14305	COG4794	Type iii secretion
E4T21_RS14310	COG4791	protein targeting
E4T21_RS14315	COG4792	protein secretion
E4T21_RS14325	COG0583	DNA-binding transcription factor activity
E4T21_RS14360	COG1902	pentaerythritol trinitrate reductase activity
E4T21_RS14360	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4T21_RS14365	COG4977	sequence-specific DNA binding
E4T21_RS14385	COG2175	clavaminate synthase activity
E4T21_RS14415	COG4215	(ABC) transporter
E4T21_RS14430	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4T21_RS14440	COG3321	synthase
E4T21_RS14440	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS14440	COG0604	alcohol dehydrogenase
E4T21_RS14445	COG0393	Putative heavy-metal-binding
E4T21_RS14470	COG1802	Transcriptional regulator
E4T21_RS14485	COG2814	Major facilitator Superfamily
E4T21_RS14525	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4T21_RS14535	COG1012	belongs to the aldehyde dehydrogenase family
E4T21_RS14545	COG2072	flavoprotein involved in K transport
E4T21_RS14565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4T21_RS14580	COG0583	DNA-binding transcription factor activity
E4T21_RS14645	COG0640	Transcriptional regulator
E4T21_RS14660	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E4T21_RS14665	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4T21_RS14675	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4T21_RS14680	COG4208	sulfate ABC transporter
E4T21_RS14685	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4T21_RS14710	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4T21_RS14730	COG3209	COG3209 Rhs family protein
E4T21_RS14785	COG3209	COG3209 Rhs family protein
E4T21_RS14800	COG3209	COG3209 Rhs family protein
E4T21_RS14815	COG3209	COG3209 Rhs family protein
E4T21_RS14850	COG0583	DNA-binding transcription factor activity
E4T21_RS14855	COG0667	Aldo Keto reductase
E4T21_RS14860	COG3795	YCII-related domain
E4T21_RS14870	COG0628	permease
E4T21_RS14880	COG1566	PFAM secretion protein HlyD family protein
E4T21_RS14900	COG0243	molybdopterin cofactor binding
E4T21_RS15035	COG0076	glutamate decarboxylase activity
E4T21_RS15040	COG3486	L-lysine 6-monooxygenase (NADPH) activity
E4T21_RS15055	COG1595	DNA-templated transcription, initiation
E4T21_RS15060	COG2814	Major facilitator Superfamily
E4T21_RS15065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4T21_RS15070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T21_RS15075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T21_RS15080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4T21_RS15110	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4T21_RS15115	COG4264	IucA IucC family
E4T21_RS15125	COG4264	IucA IucC family
E4T21_RS15130	COG0019	diaminopimelate decarboxylase activity
E4T21_RS15135	COG4264	IucA IucC family
E4T21_RS15145	COG1120	ATPase activity
E4T21_RS15170	COG1984	allophanate hydrolase subunit 2
E4T21_RS15175	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E4T21_RS15180	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E4T21_RS15200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4T21_RS15205	COG1120	ATPase activity
E4T21_RS15210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4T21_RS15220	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4T21_RS15225	COG0589	response to stress
E4T21_RS15235	COG4615	Cyclic peptide transporter
E4T21_RS15250	COG1120	ATPase activity
E4T21_RS15255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T21_RS15260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T21_RS15265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4T21_RS15270	COG4771	TonB-dependent receptor
E4T21_RS15275	COG0583	DNA-binding transcription factor activity
E4T21_RS15285	COG1566	PFAM secretion protein HlyD family protein
E4T21_RS15300	COG2133	pyrroloquinoline quinone binding
E4T21_RS15315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4T21_RS15345	COG2423	ornithine cyclodeaminase activity
E4T21_RS15350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4T21_RS15355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4T21_RS15360	COG1012	belongs to the aldehyde dehydrogenase family
E4T21_RS15365	COG1522	sequence-specific DNA binding
E4T21_RS15370	COG3608	succinylglutamate desuccinylase aspartoacylase
E4T21_RS15375	COG0006	proline dipeptidase activity
E4T21_RS15380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T21_RS15385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4T21_RS15390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4T21_RS15395	COG0625	glutathione transferase activity
E4T21_RS15400	COG1309	transcriptional regulator
E4T21_RS15415	COG2431	L-lysine efflux transmembrane transporter activity
E4T21_RS15420	COG1609	Transcriptional regulator
E4T21_RS15425	COG2205	protein histidine kinase activity
E4T21_RS15430	COG0745	RESPONSE REGULATOR receiver
E4T21_RS15450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4T21_RS15455	COG1312	Catalyzes the dehydration of D-mannonate
E4T21_RS15460	COG0246	Mannitol dehydrogenase
E4T21_RS15465	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4T21_RS15470	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4T21_RS15475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS15480	COG1063	alcohol dehydrogenase
E4T21_RS15485	COG4948	Mandelate Racemase Muconate Lactonizing
E4T21_RS15490	COG1802	Transcriptional regulator
E4T21_RS15505	COG1653	transport
E4T21_RS15520	COG0366	Alpha amylase catalytic
E4T21_RS15525	COG3842	ATPase activity
E4T21_RS15530	COG1653	transport
E4T21_RS15540	COG0583	DNA-binding transcription factor activity
E4T21_RS15550	COG1335	isochorismatase
E4T21_RS15580	COG2205	protein histidine kinase activity
E4T21_RS15580	COG0784	Response regulator, receiver
E4T21_RS15590	COG3224	Antibiotic biosynthesis monooxygenase
E4T21_RS15595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4T21_RS15595	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E4T21_RS15595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4T21_RS15600	COG1105	Belongs to the carbohydrate kinase PfkB family
E4T21_RS15610	COG1609	Transcriptional regulator
E4T21_RS15645	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4T21_RS15655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS15675	COG3842	ATPase activity
E4T21_RS15695	COG0469	pyruvate kinase activity
E4T21_RS15700	COG2084	Dehydrogenase
E4T21_RS15705	COG3622	Belongs to the hyi family
E4T21_RS15710	COG3960	tartronate-semialdehyde synthase activity
E4T21_RS15740	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS15750	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4T21_RS15750	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4T21_RS15760	COG1802	Transcriptional regulator
E4T21_RS15765	COG3257	ureidoglycine aminohydrolase activity
E4T21_RS15770	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E4T21_RS15775	COG1288	antiporter activity
E4T21_RS15795	COG1953	Uracil, thiamine, allantoin
E4T21_RS15815	COG3195	allantoin biosynthetic process
E4T21_RS15815	COG3648	Uricase
E4T21_RS15830	COG1620	l-lactate permease
E4T21_RS15840	COG1115	amino acid carrier protein
E4T21_RS15865	COG1024	Enoyl-CoA hydratase
E4T21_RS15870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4T21_RS15880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS15890	COG1802	Transcriptional regulator
E4T21_RS15895	COG0277	FAD linked oxidase domain protein
E4T21_RS15900	COG0277	FAD linked oxidase domain protein
E4T21_RS15905	COG0247	lactate metabolic process
E4T21_RS15910	COG3193	protein, possibly involved in utilization of glycolate and propanediol
E4T21_RS15915	COG0697	spore germination
E4T21_RS15920	COG3228	Belongs to the MtfA family
E4T21_RS15940	COG0583	DNA-binding transcription factor activity
E4T21_RS15945	COG0473	3-isopropylmalate dehydrogenase activity
E4T21_RS15950	COG2226	methyltransferase
E4T21_RS15955	COG3040	lipid binding
E4T21_RS15980	COG4160	amino acid transport
E4T21_RS15990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4T21_RS15995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4T21_RS16000	COG0789	Transcriptional regulator
E4T21_RS16015	COG0583	DNA-binding transcription factor activity
E4T21_RS16020	COG2855	membrane
E4T21_RS16030	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4T21_RS16035	COG3126	Type III secretion system lipoprotein chaperone (YscW)
E4T21_RS16050	COG2358	TRAP transporter, solute receptor (TAXI family
E4T21_RS16055	COG0579	oxidoreductase
E4T21_RS16060	COG0531	amino acid
E4T21_RS16090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4T21_RS16095	COG3091	SprT-like family
E4T21_RS16110	COG2937	Belongs to the GPAT DAPAT family
E4T21_RS16115	COG0742	ribosomal rna small subunit methyltransferase
E4T21_RS16120	COG1214	PFAM Peptidase M22, glycoprotease
E4T21_RS16125	COG0563	adenylate kinase activity
E4T21_RS16140	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4T21_RS16155	COG1720	tRNA m6t6A37 methyltransferase activity
E4T21_RS16160	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4T21_RS16165	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E4T21_RS16175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4T21_RS16180	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4T21_RS16195	COG4783	chaperone-mediated protein folding
E4T21_RS16205	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E4T21_RS16225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4T21_RS16230	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4T21_RS16235	COG1061	Type III restriction enzyme res subunit
E4T21_RS16250	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4T21_RS16260	COG1946	Acyl-CoA thioesterase
E4T21_RS16280	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4T21_RS16285	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4T21_RS16295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T21_RS16305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4T21_RS16305	COG2169	Transcriptional regulator
E4T21_RS16325	COG3485	protocatechuate 3,4-dioxygenase
E4T21_RS16330	COG3485	protocatechuate 3,4-dioxygenase
E4T21_RS16335	COG0583	DNA-binding transcription factor activity
E4T21_RS16340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4T21_RS16345	COG2031	fatty acid transporter
E4T21_RS16355	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4T21_RS16360	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E4T21_RS16365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4T21_RS16370	COG1414	Transcriptional regulator
E4T21_RS16380	COG0679	Auxin Efflux Carrier
E4T21_RS16385	COG1053	succinate dehydrogenase
E4T21_RS16395	COG0673	inositol 2-dehydrogenase activity
E4T21_RS16405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4T21_RS16410	COG1082	Xylose isomerase domain protein TIM barrel
E4T21_RS16410	COG3185	4-Hydroxyphenylpyruvate dioxygenase
E4T21_RS16495	COG0583	DNA-binding transcription factor activity
E4T21_RS16500	COG3135	benzoate transporter
E4T21_RS16505	COG2962	Rard protein
E4T21_RS16530	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS16545	COG0583	DNA-binding transcription factor activity
E4T21_RS16565	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
E4T21_RS16570	COG1960	acyl-CoA dehydrogenase activity
E4T21_RS16575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4T21_RS16610	COG2329	Antibiotic biosynthesis monooxygenase
E4T21_RS16615	COG5001	Diguanylate cyclase
E4T21_RS16615	COG3300	MHYT domain
E4T21_RS16620	COG1132	(ABC) transporter
E4T21_RS16625	COG0006	proline dipeptidase activity
E4T21_RS16630	COG0217	transcriptional regulatory protein
E4T21_RS16660	COG2207	Transcriptional regulator
E4T21_RS16675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4T21_RS16680	COG0583	DNA-binding transcription factor activity
E4T21_RS16685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4T21_RS16695	COG2814	Major facilitator Superfamily
E4T21_RS16705	COG0789	Transcriptional regulator
E4T21_RS16715	COG1120	ATPase activity
E4T21_RS16720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T21_RS16755	COG0003	Pfam Anion-transporting ATPase
E4T21_RS16765	COG1966	Carbon starvation protein
E4T21_RS16790	COG4221	oxidoreductase activity
E4T21_RS16800	COG0583	DNA-binding transcription factor activity
E4T21_RS16805	COG0625	glutathione transferase activity
E4T21_RS16830	COG2226	methyltransferase
E4T21_RS16835	COG0477	Major facilitator Superfamily
E4T21_RS16840	COG1566	PFAM secretion protein HlyD family protein
E4T21_RS16855	COG0640	Transcriptional regulator
E4T21_RS16860	COG1230	cation diffusion facilitator family transporter
E4T21_RS16885	COG1741	Belongs to the pirin family
E4T21_RS16890	COG0583	DNA-binding transcription factor activity
E4T21_RS16895	COG1335	isochorismatase
E4T21_RS16915	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS16920	COG2207	Transcriptional regulator
E4T21_RS16925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4T21_RS16925	COG0519	Catalyzes the synthesis of GMP from XMP
E4T21_RS16945	COG0745	RESPONSE REGULATOR receiver
E4T21_RS16970	COG1570	exodeoxyribonuclease VII activity
E4T21_RS16975	COG2204	response regulator
E4T21_RS16985	COG2205	protein histidine kinase activity
E4T21_RS16990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4T21_RS16990	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4T21_RS17005	COG2828	Protein conserved in bacteria
E4T21_RS17010	COG0583	DNA-binding transcription factor activity
E4T21_RS17015	COG0306	phosphate transporter
E4T21_RS17020	COG1392	Phosphate transport regulator
E4T21_RS17025	COG3025	triphosphatase activity
E4T21_RS17030	COG0009	L-threonylcarbamoyladenylate synthase
E4T21_RS17035	COG0613	PHP domain protein
E4T21_RS17040	COG2350	Protein conserved in bacteria
E4T21_RS17045	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4T21_RS17045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T21_RS17055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4T21_RS17060	COG3115	cell septum assembly
E4T21_RS17085	COG1138	Cytochrome C-type biogenesis protein
E4T21_RS17090	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E4T21_RS17110	COG4133	protoheme IX ABC transporter activity
E4T21_RS17115	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4T21_RS17120	COG1739	Uncharacterized protein family UPF0029
E4T21_RS17130	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
E4T21_RS17145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4T21_RS17150	COG0513	Belongs to the DEAD box helicase family
E4T21_RS17175	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4T21_RS17180	COG0527	aspartate kinase activity
E4T21_RS17185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4T21_RS17190	COG2137	regulation of response to DNA damage stimulus
E4T21_RS17195	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4T21_RS17200	COG1546	Belongs to the CinA family
E4T21_RS17210	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4T21_RS17240	COG2354	Protein conserved in bacteria
E4T21_RS17245	COG3724	N-succinylarginine dihydrolase activity
E4T21_RS17250	COG1012	belongs to the aldehyde dehydrogenase family
E4T21_RS17280	COG0037	tRNA processing
E4T21_RS17300	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4T21_RS17310	COG2198	Histidine kinase
E4T21_RS17310	COG0784	Response regulator, receiver
E4T21_RS17310	COG2205	protein histidine kinase activity
E4T21_RS17315	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E4T21_RS17325	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS17350	COG0318	PFAM AMP-dependent synthetase and ligase
E4T21_RS17365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4T21_RS17375	COG4680	protein conserved in bacteria
E4T21_RS17380	COG1944	ATP diphosphatase activity
E4T21_RS17385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4T21_RS17420	COG0488	(ABC) transporter
E4T21_RS17425	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4T21_RS17430	COG1074	ATP-dependent DNA helicase activity
E4T21_RS17435	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4T21_RS17450	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4T21_RS17465	COG5002	protein histidine kinase activity
E4T21_RS17465	COG5001	Diguanylate cyclase
E4T21_RS17485	COG2084	Dehydrogenase
E4T21_RS17490	COG1012	belongs to the aldehyde dehydrogenase family
E4T21_RS17495	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4T21_RS17495	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4T21_RS17505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS17510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4T21_RS17515	COG3622	Belongs to the hyi family
E4T21_RS17520	COG0235	Class ii aldolase
E4T21_RS17525	COG3395	kinase activity
E4T21_RS17530	COG2084	Dehydrogenase
E4T21_RS17535	COG1609	Transcriptional regulator
E4T21_RS17540	COG2095	MarC family integral membrane protein
E4T21_RS17545	COG1129	ABC transporter
E4T21_RS17550	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4T21_RS17555	COG1879	ABC-type sugar transport system periplasmic component
E4T21_RS17560	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS17575	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS17585	COG2084	Dehydrogenase
E4T21_RS17590	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4T21_RS17600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS17605	COG3958	Transketolase
E4T21_RS17610	COG3959	Transketolase, thiamine diphosphate binding domain
E4T21_RS17625	COG2376	Dihydroxyacetone kinase
E4T21_RS17630	COG0698	ribose 5-phosphate isomerase
E4T21_RS17635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4T21_RS17640	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4T21_RS17665	COG3622	Belongs to the hyi family
E4T21_RS17680	COG1129	ABC transporter
E4T21_RS17685	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4T21_RS17695	COG2986	histidine ammonia-lyase
E4T21_RS17700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4T21_RS17715	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4T21_RS17725	COG0386	Belongs to the glutathione peroxidase family
E4T21_RS17735	COG1960	acyl-CoA dehydrogenase activity
E4T21_RS17745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4T21_RS17750	COG0798	PFAM Bile acid sodium symporter
E4T21_RS17755	COG0431	NADPH-dependent FMN reductase
E4T21_RS17775	COG0471	metal ion transport
E4T21_RS17780	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4T21_RS17785	COG0343	queuine tRNA-ribosyltransferase activity
E4T21_RS17790	COG1862	Preprotein translocase
E4T21_RS17805	COG1253	flavin adenine dinucleotide binding
E4T21_RS17840	COG0105	UTP biosynthetic process
E4T21_RS17845	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4T21_RS17860	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4T21_RS17865	COG0124	histidyl-tRNA synthetase
E4T21_RS17870	COG2976	Protein conserved in bacteria
E4T21_RS17875	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4T21_RS17880	COG1160	GTP binding
E4T21_RS17910	COG2732	(Barnase) inhibitor
E4T21_RS17920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4T21_RS17925	COG0408	coproporphyrinogen oxidase activity
E4T21_RS17930	COG0009	L-threonylcarbamoyladenylate synthase
E4T21_RS17935	COG0758	DNA mediated transformation
E4T21_RS17940	COG0242	peptide deformylase activity
E4T21_RS17945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4T21_RS17955	COG3360	Dodecin
E4T21_RS17960	COG0569	domain protein
E4T21_RS17970	COG3148	PFAM DTW domain containing protein
E4T21_RS17975	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E4T21_RS17980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4T21_RS17985	COG0564	pseudouridine synthase activity
E4T21_RS17990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4T21_RS18050	COG0795	lipopolysaccharide-transporting ATPase activity
E4T21_RS18055	COG0795	lipopolysaccharide-transporting ATPase activity
E4T21_RS18060	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4T21_RS18065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4T21_RS18085	COG0525	valine-tRNA ligase activity
E4T21_RS18090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T21_RS18125	COG0471	metal ion transport
E4T21_RS18140	COG0346	lactoylglutathione lyase activity
E4T21_RS18145	COG2818	Glycosylase
E4T21_RS18165	COG4302	ethanolamine ammonia-lyase activity
E4T21_RS18170	COG0531	amino acid
E4T21_RS18175	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4T21_RS18185	COG0583	DNA-binding transcription factor activity
E4T21_RS18190	COG2205	protein histidine kinase activity
E4T21_RS18195	COG0745	RESPONSE REGULATOR receiver
E4T21_RS18200	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4T21_RS18200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4T21_RS18205	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4T21_RS18215	COG1051	belongs to the nudix hydrolase family
E4T21_RS18225	COG2358	TRAP transporter, solute receptor (TAXI family
E4T21_RS18230	COG2831	hemolysin activation secretion protein
E4T21_RS18235	COG3210	domain, Protein
E4T21_RS18245	COG3415	Transposase
E4T21_RS18245	COG2801	Transposase and inactivated derivatives
E4T21_RS18250	COG0697	spore germination
E4T21_RS18255	COG2207	Transcriptional regulator
E4T21_RS18255	COG0662	Cupin 2, conserved barrel domain protein
E4T21_RS18260	COG0583	DNA-binding transcription factor activity
E4T21_RS18285	COG0625	glutathione transferase activity
E4T21_RS18305	COG3577	Aspartyl protease
E4T21_RS18310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4T21_RS18340	COG1757	Na H antiporter
E4T21_RS18345	COG2957	Belongs to the agmatine deiminase family
E4T21_RS18365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4T21_RS18370	COG0154	amidase activity
E4T21_RS18380	COG1070	Carbohydrate kinase
E4T21_RS18390	COG1072	(Pantothenic acid kinase))
E4T21_RS18400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4T21_RS18405	COG3842	ATPase activity
E4T21_RS18415	COG1175	transmembrane transport
E4T21_RS18420	COG1653	transport
E4T21_RS18425	COG2390	Transcriptional regulator
E4T21_RS18435	COG0745	RESPONSE REGULATOR receiver
E4T21_RS18465	COG0659	secondary active sulfate transmembrane transporter activity
E4T21_RS18470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4T21_RS18475	COG4772	TonB-dependent receptor
E4T21_RS18490	COG2217	Heavy metal translocating P-type atpase
E4T21_RS18495	COG0346	lactoylglutathione lyase activity
E4T21_RS18510	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4T21_RS18515	COG0625	glutathione transferase activity
E4T21_RS18530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4T21_RS18540	COG0335	large ribosomal subunit rRNA binding
E4T21_RS18545	COG0336	Belongs to the RNA methyltransferase TrmD family
E4T21_RS18550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4T21_RS18555	COG0228	four-way junction DNA binding
E4T21_RS18560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4T21_RS18570	COG4536	flavin adenine dinucleotide binding
E4T21_RS18590	COG1025	Belongs to the peptidase M16 family
E4T21_RS18595	COG2925	Exonuclease
E4T21_RS18600	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E4T21_RS18605	COG2894	cell division
E4T21_RS18610	COG0850	regulation of cytokinetic process
E4T21_RS18620	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS18630	COG3118	belongs to the thioredoxin family
E4T21_RS18635	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4T21_RS18650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4T21_RS18680	COG0667	Aldo Keto reductase
E4T21_RS18685	COG3022	response to hydroperoxide
E4T21_RS18720	COG0247	lactate metabolic process
E4T21_RS18735	COG1139	Iron-sulfur cluster binding protein
E4T21_RS18740	COG0247	lactate metabolic process
E4T21_RS18765	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4T21_RS18775	COG0733	neurotransmitter:sodium symporter activity
E4T21_RS18780	COG0339	signal peptide processing
E4T21_RS18800	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E4T21_RS18810	COG1757	Na H antiporter
E4T21_RS18825	COG0625	glutathione transferase activity
E4T21_RS18830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4T21_RS18845	COG4221	oxidoreductase activity
E4T21_RS18860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4T21_RS18865	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E4T21_RS18870	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4T21_RS18875	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4T21_RS18880	COG1830	Aldolase
E4T21_RS18895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4T21_RS18900	COG0126	phosphoglycerate kinase activity
E4T21_RS18910	COG0546	phosphoglycolate phosphatase activity
E4T21_RS18915	COG1609	Transcriptional regulator
E4T21_RS18920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4T21_RS18935	COG1051	belongs to the nudix hydrolase family
E4T21_RS18935	COG1056	cytidyltransferase-related domain
E4T21_RS18945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4T21_RS18965	COG0154	amidase activity
E4T21_RS18970	COG0583	DNA-binding transcription factor activity
E4T21_RS18980	COG1185	polyribonucleotide nucleotidyltransferase activity
E4T21_RS19000	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4T21_RS19005	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4T21_RS19010	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4T21_RS19015	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4T21_RS19020	COG0195	Participates in both transcription termination and antitermination
E4T21_RS19025	COG0779	Required for maturation of 30S ribosomal subunits
E4T21_RS19045	COG0149	triose-phosphate isomerase activity
E4T21_RS19050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4T21_RS19055	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4T21_RS19060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4T21_RS19065	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4T21_RS19075	COG1741	Belongs to the pirin family
E4T21_RS19095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E4T21_RS19120	COG4139	cobalamin transport
E4T21_RS19125	COG1120	ATPase activity
E4T21_RS19135	COG0484	heat shock protein binding
E4T21_RS19140	COG0443	Heat shock 70 kDa protein
E4T21_RS19145	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4T21_RS19150	COG0497	DNA recombination
E4T21_RS19160	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4T21_RS19165	COG2914	Belongs to the UPF0125 (RnfH) family
E4T21_RS19170	COG2867	negative regulation of translational initiation
E4T21_RS19175	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4T21_RS19190	COG0251	oxidation-reduction process
E4T21_RS19195	COG0583	DNA-binding transcription factor activity
E4T21_RS19200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS19210	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4T21_RS19215	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
E4T21_RS19225	COG0725	ABC transporter, periplasmic molybdate-binding protein
E4T21_RS19230	COG4149	molybdate abc transporter
E4T21_RS19235	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E4T21_RS19260	COG1280	lysine exporter protein (LysE YggA)
E4T21_RS19270	COG1879	ABC-type sugar transport system periplasmic component
E4T21_RS19275	COG1129	ABC transporter
E4T21_RS19280	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4T21_RS19290	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS19295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4T21_RS19315	COG2814	Major facilitator Superfamily
E4T21_RS19320	COG0113	porphobilinogen synthase activity
E4T21_RS19355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4T21_RS19360	COG0569	domain protein
E4T21_RS19365	COG5001	Diguanylate cyclase
E4T21_RS19365	COG3300	MHYT domain
E4T21_RS19375	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4T21_RS19380	COG1121	(ABC) transporter
E4T21_RS19385	COG1321	iron dependent repressor
E4T21_RS19385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4T21_RS19390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4T21_RS19420	COG1082	Xylose isomerase domain protein TIM barrel
E4T21_RS19425	COG0673	inositol 2-dehydrogenase activity
E4T21_RS19445	COG3962	Belongs to the TPP enzyme family
E4T21_RS19450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4T21_RS19455	COG0673	inositol 2-dehydrogenase activity
E4T21_RS19460	COG1082	Xylose isomerase domain protein TIM barrel
E4T21_RS19475	COG3718	enzyme involved in inositol metabolism
E4T21_RS19480	COG0673	inositol 2-dehydrogenase activity
E4T21_RS19485	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4T21_RS19495	COG1028	Short-chain dehydrogenase reductase Sdr
E4T21_RS19505	COG1879	ABC-type sugar transport system periplasmic component
E4T21_RS19530	COG1803	Methylglyoxal synthase
E4T21_RS19535	COG0166	Belongs to the GPI family
E4T21_RS19540	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E4T21_RS19545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E4T21_RS19550	COG0668	transmembrane transport
E4T21_RS19575	COG0181	hydroxymethylbilane synthase activity
E4T21_RS19580	COG0165	Argininosuccinate lyase
E4T21_RS19590	COG0019	diaminopimelate decarboxylase activity
E4T21_RS19595	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E4T21_RS19605	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E4T21_RS19610	COG1011	Hydrolase
E4T21_RS19615	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4T21_RS19640	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4T21_RS19645	COG1238	metal cluster binding
E4T21_RS19660	COG1490	D-aminoacyl-tRNA deacylase activity
E4T21_RS19670	COG0488	(ABC) transporter
E4T21_RS19680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4T21_RS19685	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4T21_RS19690	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4T21_RS19695	COG0589	response to stress
E4T21_RS19705	COG1999	signal sequence binding
E4T21_RS19720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4T21_RS19735	COG2363	Small membrane protein
E4T21_RS19745	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4T21_RS19760	COG0251	oxidation-reduction process
E4T21_RS19770	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4T21_RS19790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4T21_RS19795	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E4T21_RS19815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4T21_RS19820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4T21_RS19820	COG2813	Specifically methylates the guanine in position
E4T21_RS19830	COG1489	DNA binding
E4T21_RS19835	COG0436	Aminotransferase
E4T21_RS19840	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4T21_RS19860	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E4T21_RS19865	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E4T21_RS19870	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
E4T21_RS19875	COG0023	Translation Initiation Factor
E4T21_RS19880	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4T21_RS19905	COG2204	response regulator
E4T21_RS19910	COG3852	Histidine kinase
E4T21_RS19925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T21_RS19930	COG1757	Na H antiporter
E4T21_RS19955	COG0559	Belongs to the binding-protein-dependent transport system permease family
E4T21_RS19995	COG3720	iron ion transport
E4T21_RS20010	COG1121	(ABC) transporter
E4T21_RS20020	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4T21_RS20035	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
E4T21_RS20040	COG0352	thiamine-phosphate diphosphorylase activity
E4T21_RS20045	COG0697	spore germination
E4T21_RS20050	COG1686	Belongs to the peptidase S11 family
E4T21_RS20065	COG5383	Protein conserved in bacteria
E4T21_RS20070	COG0583	DNA-binding transcription factor activity
E4T21_RS20075	COG1126	abc transporter atp-binding protein
E4T21_RS20080	COG0765	amino acid transport
E4T21_RS20085	COG4597	amino acid ABC transporter
E4T21_RS20095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T21_RS20105	COG1017	nitric oxide dioxygenase activity
E4T21_RS20105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4T21_RS20135	COG0028	Belongs to the TPP enzyme family
E4T21_RS20180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4T21_RS20190	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E4T21_RS20205	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4T21_RS20225	COG3639	organic phosphonate transmembrane transporter activity
E4T21_RS20245	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4T21_RS20250	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E4T21_RS20255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4T21_RS20260	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E4T21_RS20265	COG4942	peptidase
E4T21_RS20270	COG0793	Belongs to the peptidase S41A family
E4T21_RS20275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4T21_RS20280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4T21_RS20285	COG0006	proline dipeptidase activity
E4T21_RS20295	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4T21_RS20305	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4T21_RS20310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4T21_RS20315	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4T21_RS20320	COG1519	Transferase
E4T21_RS20325	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4T21_RS20325	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4T21_RS20330	COG0859	PFAM glycosyl transferase family 9
E4T21_RS20335	COG3642	lipopolysaccharide core region biosynthetic process
E4T21_RS20340	COG0438	transferase activity, transferring glycosyl groups
E4T21_RS20345	COG0859	PFAM glycosyl transferase family 9
E4T21_RS20350	COG0463	Glycosyl transferase, family 2
E4T21_RS20380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4T21_RS20385	COG0752	glycyl-tRNA synthetase alpha subunit
E4T21_RS20390	COG0751	glycine-tRNA ligase activity
E4T21_RS20395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T21_RS20395	COG3321	synthase
E4T21_RS20395	COG0604	alcohol dehydrogenase
E4T21_RS20395	COG4221	oxidoreductase activity
E4T21_RS20400	COG0583	DNA-binding transcription factor activity
E4T21_RS20415	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4T21_RS20425	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4T21_RS20430	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4T21_RS20435	COG0594	ribonuclease P activity
E4T21_RS20440	COG0706	membrane insertase activity
E4T21_RS20445	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4T21_RS20450	COG2910	NAD(P)H-binding
E4T21_RS20455	COG0697	spore germination
E4T21_RS20460	COG1846	Transcriptional regulator
E4T21_RS20465	COG5507	3-demethylubiquinone-9 3-methyltransferase
E4T21_RS20470	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4T21_RS20475	COG2885	chlorophyll binding
E4T21_RS20480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4T21_RS20500	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4T21_RS20505	COG0351	phosphomethylpyrimidine kinase
E4T21_RS20510	COG1981	membrane
E4T21_RS20525	COG0316	Belongs to the HesB IscA family
E4T21_RS20530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T21_RS20535	COG0765	amino acid transport
E4T21_RS20540	COG1126	abc transporter atp-binding protein
E4T21_RS20545	COG0445	tRNA wobble uridine modification
E4T21_RS20550	COG0357	Ribosomal RNA small subunit methyltransferase G
E4T21_RS20555	COG1192	Involved in chromosome partitioning
E4T21_RS20560	COG1475	DNA binding
E4T21_RS20570	COG0356	it plays a direct role in the translocation of protons across the membrane
E4T21_RS20580	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E4T21_RS20585	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4T21_RS20590	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E4T21_RS20595	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E4T21_RS20600	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E4T21_RS20605	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E4T21_RS20610	COG2239	Acts as a magnesium transporter
E4T21_RS20615	COG1968	undecaprenyl-diphosphatase activity
E4T21_RS20620	COG1477	protein flavinylation
E4T21_RS20625	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4T21_RS20630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4T21_RS20640	COG3121	Chaperone
E4T21_RS20645	COG3188	usher protein
E4T21_RS20655	COG0534	Mate efflux family protein
E4T21_RS20660	COG1801	Protein of unknown function DUF72
E4T21_RS20665	COG0733	neurotransmitter:sodium symporter activity
E4T21_RS20675	COG1737	Transcriptional regulator
E4T21_RS20680	COG0210	DNA helicase
E4T21_RS20685	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E4T21_RS20690	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4T21_RS20695	COG0573	inorganic phosphate transmembrane transporter activity
E4T21_RS20700	COG0581	inorganic phosphate transmembrane transporter activity
E4T21_RS20705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4T21_RS20710	COG0704	Plays a role in the regulation of phosphate uptake
E4T21_RS20715	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
E4T21_RS20730	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E4T21_RS20735	COG3161	chorismate lyase activity
E4T21_RS20755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4T21_RS20760	COG0583	DNA-binding transcription factor activity
E4T21_RS20780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4T21_RS20785	COG1758	RNA polymerase activity
E4T21_RS20790	COG0194	GDP metabolic process
E4T21_RS20800	COG4589	Belongs to the CDS family
E4T21_RS20815	COG2814	Major facilitator Superfamily
E4T21_RS20840	COG1288	antiporter activity
E4T21_RS20855	COG3104	oligopeptide transport
E4T21_RS20860	COG1741	Belongs to the pirin family
E4T21_RS20865	COG0583	DNA-binding transcription factor activity
E4T21_RS20880	COG3181	Tripartite tricarboxylate transporter family receptor
E4T21_RS20900	COG0277	FAD linked oxidase domain protein
E4T21_RS20905	COG4948	Mandelate Racemase Muconate Lactonizing
E4T21_RS20925	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E4T21_RS20955	COG1561	YicC-like family, N-terminal region
E4T21_RS20960	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E4T21_RS20970	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4T21_RS20975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4T21_RS20985	COG2814	Major facilitator Superfamily
E4T21_RS21045	COG1733	regulation of RNA biosynthetic process
E4T21_RS21050	COG4565	transcriptional regulatory protein
E4T21_RS21055	COG3290	protein histidine kinase activity
E4T21_RS21090	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4T21_RS21095	COG1522	sequence-specific DNA binding
E4T21_RS21100	COG1191	sigma factor activity
E4T21_RS21110	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4T21_RS21125	COG0745	RESPONSE REGULATOR receiver
E4T21_RS21135	COG2201	protein-glutamate methylesterase activity
E4T21_RS21140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4T21_RS21145	COG0840	transmembrane signaling receptor activity
E4T21_RS21150	COG0835	chemotaxis
E4T21_RS21155	COG0643	Histidine kinase
E4T21_RS21155	COG2198	Histidine kinase
E4T21_RS21160	COG1360	Flagellar Motor Protein
E4T21_RS21210	COG3539	Fimbrial protein
E4T21_RS21215	COG3539	Fimbrial protein
E4T21_RS21220	COG3121	Chaperone
E4T21_RS21225	COG3188	usher protein
E4T21_RS21230	COG3539	Fimbrial protein
E4T21_RS21255	COG1558	bacterial-type flagellum-dependent cell motility
E4T21_RS21260	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4T21_RS21265	COG1749	Flagellar hook protein flgE
E4T21_RS21285	COG1706	bacterial-type flagellum-dependent cell motility
E4T21_RS21290	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4T21_RS21290	COG1705	Flagellar rod assembly protein muramidase FlgJ
E4T21_RS21325	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4T21_RS21330	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4T21_RS21360	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4T21_RS21370	COG1677	Flagellar hook-basal body complex protein FliE
E4T21_RS21375	COG3634	alkyl hydroperoxide reductase activity