locus-tag	class	description
E8A47_RS00030	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E8A47_RS00030	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E8A47_RS00035	COG0842	Transport permease protein
E8A47_RS00040	COG1131	(ABC) transporter
E8A47_RS00075	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E8A47_RS00085	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS00095	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E8A47_RS00100	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E8A47_RS00105	COG0436	Aminotransferase
E8A47_RS00110	COG0501	Belongs to the peptidase M48B family
E8A47_RS00115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E8A47_RS00130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E8A47_RS00130	COG0116	Belongs to the methyltransferase superfamily
E8A47_RS00135	COG3130	regulation of translation
E8A47_RS00140	COG0167	dihydroorotate dehydrogenase activity
E8A47_RS00145	COG2902	Dehydrogenase
E8A47_RS00150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E8A47_RS00155	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E8A47_RS00165	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E8A47_RS00170	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E8A47_RS00175	COG1674	ftsk spoiiie
E8A47_RS00180	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E8A47_RS00185	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E8A47_RS00190	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E8A47_RS00195	COG0542	response to heat
E8A47_RS00200	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E8A47_RS00220	COG0482	sulfurtransferase activity
E8A47_RS00225	COG2915	High frequency lysogenization protein hflD homolog
E8A47_RS00235	COG2850	peptidyl-arginine hydroxylation
E8A47_RS00270	COG0747	negative chemotaxis
E8A47_RS00275	COG0601	transmembrane transport
E8A47_RS00280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E8A47_RS00285	COG0577	efflux transmembrane transporter activity
E8A47_RS00285	COG1136	(ABC) transporter
E8A47_RS00290	COG1124	(ABC) transporter
E8A47_RS00295	COG2814	Major facilitator Superfamily
E8A47_RS00300	COG0791	NLP P60 protein
E8A47_RS00315	COG0676	glucose-6-phosphate 1-epimerase activity
E8A47_RS00325	COG3106	COG3106 Predicted ATPase
E8A47_RS00330	COG3768	UPF0283 membrane protein
E8A47_RS00335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E8A47_RS00340	COG3842	ATPase activity
E8A47_RS00345	COG0395	ABC-type sugar transport system, permease component
E8A47_RS00350	COG1175	transmembrane transport
E8A47_RS00395	COG1136	(ABC) transporter
E8A47_RS00395	COG0577	efflux transmembrane transporter activity
E8A47_RS00400	COG0577	efflux transmembrane transporter activity
E8A47_RS00400	COG1136	(ABC) transporter
E8A47_RS00435	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
E8A47_RS00450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E8A47_RS00455	COG0840	transmembrane signaling receptor activity
E8A47_RS00505	COG1053	succinate dehydrogenase
E8A47_RS00510	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E8A47_RS00535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E8A47_RS00555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E8A47_RS00590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8A47_RS00595	COG1538	Outer membrane efflux protein
E8A47_RS00600	COG3604	Transcriptional regulator
E8A47_RS00605	COG2116	formate transmembrane transporter activity
E8A47_RS00610	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
E8A47_RS00615	COG3001	Fructosamine kinase
E8A47_RS00620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E8A47_RS00625	COG1070	Carbohydrate kinase
E8A47_RS00635	COG1072	(Pantothenic acid kinase))
E8A47_RS00650	COG3842	ATPase activity
E8A47_RS00660	COG1175	transmembrane transport
E8A47_RS00695	COG1376	ErfK ybiS ycfS ynhG family protein
E8A47_RS00705	COG1764	response to oxidative stress
E8A47_RS00710	COG0697	spore germination
E8A47_RS00720	COG1609	Transcriptional regulator
E8A47_RS00725	COG3265	gluconokinase activity
E8A47_RS00730	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS00740	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS00745	COG1846	Transcriptional regulator
E8A47_RS00750	COG1764	response to oxidative stress
E8A47_RS00755	COG1794	racemase activity, acting on amino acids and derivatives
E8A47_RS00760	COG0625	glutathione transferase activity
E8A47_RS00785	COG0625	glutathione transferase activity
E8A47_RS00795	COG1024	Enoyl-CoA hydratase
E8A47_RS00800	COG1250	3-hydroxyacyl-CoA dehydrogenase
E8A47_RS00805	COG0318	PFAM AMP-dependent synthetase and ligase
E8A47_RS00810	COG1960	acyl-CoA dehydrogenase activity
E8A47_RS00855	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
E8A47_RS00880	COG0438	transferase activity, transferring glycosyl groups
E8A47_RS00915	COG3791	Glutathione-dependent formaldehyde-activating
E8A47_RS00920	COG0583	DNA-binding transcription factor activity
E8A47_RS00935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8A47_RS00940	COG4977	sequence-specific DNA binding
E8A47_RS00945	COG1971	Probably functions as a manganese efflux pump
E8A47_RS00950	COG1595	DNA-templated transcription, initiation
E8A47_RS00960	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E8A47_RS00965	COG0477	Major facilitator Superfamily
E8A47_RS00985	COG0789	Transcriptional regulator
E8A47_RS00995	COG0583	DNA-binding transcription factor activity
E8A47_RS01000	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E8A47_RS01015	COG3070	regulator of competence-specific genes
E8A47_RS01035	COG0583	DNA-binding transcription factor activity
E8A47_RS01045	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E8A47_RS01050	COG1119	ATPase activity
E8A47_RS01060	COG0667	Aldo Keto reductase
E8A47_RS01065	COG2814	Major facilitator Superfamily
E8A47_RS01070	COG0583	DNA-binding transcription factor activity
E8A47_RS01075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E8A47_RS01105	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E8A47_RS01130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E8A47_RS01145	COG0656	L-ascorbic acid biosynthetic process
E8A47_RS01180	COG2897	thiosulfate sulfurtransferase activity
E8A47_RS01185	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E8A47_RS01195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8A47_RS01200	COG1129	ABC transporter
E8A47_RS01200	COG0842	Transport permease protein
E8A47_RS01205	COG0842	Transport permease protein
E8A47_RS01215	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS01225	COG0589	response to stress
E8A47_RS01240	COG1063	alcohol dehydrogenase
E8A47_RS01245	COG0471	metal ion transport
E8A47_RS01260	COG1566	PFAM secretion protein HlyD family protein
E8A47_RS01275	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E8A47_RS01280	COG0280	phosphate acetyltransferase
E8A47_RS01280	COG0857	belongs to the CobB CobQ family
E8A47_RS01285	COG0109	protoheme IX farnesyltransferase activity
E8A47_RS01295	COG1845	cytochrome c oxidase, subunit III
E8A47_RS01300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E8A47_RS01305	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E8A47_RS01310	COG1349	DNA-binding transcription factor activity
E8A47_RS01320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E8A47_RS01325	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E8A47_RS01330	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E8A47_RS01335	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E8A47_RS01340	COG0813	purine-nucleoside phosphorylase activity
E8A47_RS01365	COG1609	Transcriptional regulator
E8A47_RS01370	COG0673	inositol 2-dehydrogenase activity
E8A47_RS01385	COG0516	GMP reductase activity
E8A47_RS01385	COG0517	IMP dehydrogenase activity
E8A47_RS01395	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E8A47_RS01405	COG0668	transmembrane transport
E8A47_RS01415	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E8A47_RS01425	COG0519	Catalyzes the synthesis of GMP from XMP
E8A47_RS01425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E8A47_RS01430	COG1515	deoxyribonuclease V activity
E8A47_RS01455	COG0435	Glutathione S-transferase
E8A47_RS01460	COG0583	DNA-binding transcription factor activity
E8A47_RS01465	COG0739	heme binding
E8A47_RS01470	COG2989	Protein conserved in bacteria
E8A47_RS01490	COG2223	nitrite transmembrane transporter activity
E8A47_RS01495	COG3707	response regulator
E8A47_RS01500	COG4221	oxidoreductase activity
E8A47_RS01505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E8A47_RS01535	COG2059	Chromate
E8A47_RS01540	COG2059	Chromate
E8A47_RS01545	COG3181	Tripartite tricarboxylate transporter family receptor
E8A47_RS01570	COG0840	transmembrane signaling receptor activity
E8A47_RS01575	COG5001	Diguanylate cyclase
E8A47_RS01575	COG4251	negative regulation of phosphorylation
E8A47_RS01575	COG3706	GGDEF domain
E8A47_RS01575	COG2203	Gaf domain
E8A47_RS01580	COG2198	Histidine kinase
E8A47_RS01580	COG5002	protein histidine kinase activity
E8A47_RS01580	COG0784	Response regulator, receiver
E8A47_RS01590	COG0745	RESPONSE REGULATOR receiver
E8A47_RS01605	COG0656	L-ascorbic acid biosynthetic process
E8A47_RS01625	COG0243	molybdopterin cofactor binding
E8A47_RS01630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E8A47_RS01635	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E8A47_RS01635	COG2146	nitrite reductase [NAD(P)H] activity
E8A47_RS01675	COG3501	Rhs element vgr protein
E8A47_RS01685	COG2814	Major facilitator Superfamily
E8A47_RS01690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E8A47_RS01700	COG2186	Transcriptional regulator
E8A47_RS01710	COG0028	Belongs to the TPP enzyme family
E8A47_RS01735	COG2721	sulfolactate sulfo-lyase activity
E8A47_RS01755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E8A47_RS01780	COG4948	Mandelate Racemase Muconate Lactonizing
E8A47_RS01790	COG0501	Belongs to the peptidase M48B family
E8A47_RS01795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E8A47_RS01800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E8A47_RS01800	COG0723	plastoquinol--plastocyanin reductase activity
E8A47_RS01805	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E8A47_RS01820	COG2186	Transcriptional regulator
E8A47_RS01825	COG3250	beta-galactosidase activity
E8A47_RS01830	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS01845	COG1501	Belongs to the glycosyl hydrolase 31 family
E8A47_RS01850	COG1904	glucuronate isomerase
E8A47_RS01860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E8A47_RS01870	COG3712	iron ion homeostasis
E8A47_RS01875	COG1595	DNA-templated transcription, initiation
E8A47_RS01885	COG4774	siderophore transport
E8A47_RS01905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E8A47_RS01910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E8A47_RS01915	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS01925	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS01960	COG4615	Cyclic peptide transporter
E8A47_RS01965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E8A47_RS01980	COG4942	peptidase
E8A47_RS02005	COG3093	addiction module antidote protein HigA
E8A47_RS02030	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E8A47_RS02045	COG0657	acetylesterase activity
E8A47_RS02050	COG4774	siderophore transport
E8A47_RS02055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E8A47_RS02100	COG1595	DNA-templated transcription, initiation
E8A47_RS02115	COG0483	inositol monophosphate 1-phosphatase activity
E8A47_RS02120	COG1120	ATPase activity
E8A47_RS02130	COG4615	Cyclic peptide transporter
E8A47_RS02155	COG0583	DNA-binding transcription factor activity
E8A47_RS02170	COG0583	DNA-binding transcription factor activity
E8A47_RS02185	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E8A47_RS02190	COG2130	NADP-dependent
E8A47_RS02200	COG4772	TonB-dependent receptor
E8A47_RS02215	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS02235	COG1301	dicarboxylic acid transport
E8A47_RS02240	COG2207	Transcriptional regulator
E8A47_RS02245	COG4221	oxidoreductase activity
E8A47_RS02250	COG1278	Cold shock
E8A47_RS02255	COG2226	methyltransferase
E8A47_RS02290	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E8A47_RS02295	COG5499	transcription regulator containing HTH domain
E8A47_RS02320	COG0069	glutamate synthase activity
E8A47_RS02325	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E8A47_RS02330	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E8A47_RS02335	COG2249	NAD(P)H dehydrogenase (quinone) activity
E8A47_RS02340	COG0583	DNA-binding transcription factor activity
E8A47_RS02360	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
E8A47_RS02365	COG0583	DNA-binding transcription factor activity
E8A47_RS02375	COG2814	Major facilitator Superfamily
E8A47_RS02395	COG1566	PFAM secretion protein HlyD family protein
E8A47_RS02410	COG0251	oxidation-reduction process
E8A47_RS02415	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
E8A47_RS02435	COG2207	Transcriptional regulator
E8A47_RS02440	COG2259	Doxx family
E8A47_RS02470	COG0110	maltose O-acetyltransferase activity
E8A47_RS02475	COG3083	sulfuric ester hydrolase activity
E8A47_RS02480	COG0519	Catalyzes the synthesis of GMP from XMP
E8A47_RS02480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E8A47_RS02510	COG0642	Histidine kinase
E8A47_RS02540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E8A47_RS02550	COG2807	transmembrane transport
E8A47_RS02600	COG4774	siderophore transport
E8A47_RS02625	COG2814	Major facilitator Superfamily
E8A47_RS02635	COG0583	DNA-binding transcription factor activity
E8A47_RS02640	COG1288	antiporter activity
E8A47_RS02645	COG0006	proline dipeptidase activity
E8A47_RS02650	COG1288	antiporter activity
E8A47_RS02655	COG2195	Cleaves the N-terminal amino acid of tripeptides
E8A47_RS02660	COG0583	DNA-binding transcription factor activity
E8A47_RS02670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E8A47_RS02680	COG0745	RESPONSE REGULATOR receiver
E8A47_RS02685	COG2205	protein histidine kinase activity
E8A47_RS02695	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
E8A47_RS02705	COG1846	Transcriptional regulator
E8A47_RS02705	COG0456	acetyltransferase
E8A47_RS02720	COG1733	regulation of RNA biosynthetic process
E8A47_RS02750	COG0583	DNA-binding transcription factor activity
E8A47_RS02755	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E8A47_RS02760	COG4993	Dehydrogenase
E8A47_RS02780	COG2354	Protein conserved in bacteria
E8A47_RS02785	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS02800	COG0583	DNA-binding transcription factor activity
E8A47_RS02860	COG0583	DNA-binding transcription factor activity
E8A47_RS02875	COG0583	DNA-binding transcription factor activity
E8A47_RS02880	COG0456	acetyltransferase
E8A47_RS02895	COG2354	Protein conserved in bacteria
E8A47_RS02920	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E8A47_RS02920	COG0519	Catalyzes the synthesis of GMP from XMP
E8A47_RS02935	COG0583	DNA-binding transcription factor activity
E8A47_RS02955	COG3340	Belongs to the peptidase S51 family
E8A47_RS02970	COG1570	exodeoxyribonuclease VII activity
E8A47_RS02980	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS02990	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E8A47_RS03000	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E8A47_RS03000	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E8A47_RS03005	COG0306	phosphate transporter
E8A47_RS03010	COG1392	Phosphate transport regulator
E8A47_RS03020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E8A47_RS03030	COG0009	L-threonylcarbamoyladenylate synthase
E8A47_RS03035	COG0613	PHP domain protein
E8A47_RS03040	COG2350	Protein conserved in bacteria
E8A47_RS03045	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E8A47_RS03045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E8A47_RS03055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E8A47_RS03090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E8A47_RS03090	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E8A47_RS03100	COG0789	Transcriptional regulator
E8A47_RS03120	COG0789	Transcriptional regulator
E8A47_RS03125	COG2217	Heavy metal translocating P-type atpase
E8A47_RS03135	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E8A47_RS03140	COG1388	LysM domain
E8A47_RS03140	COG1376	ErfK ybiS ycfS ynhG family protein
E8A47_RS03155	COG3039	Transposase
E8A47_RS03170	COG2194	sulfuric ester hydrolase activity
E8A47_RS03180	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E8A47_RS03240	COG1061	Type III restriction enzyme res subunit
E8A47_RS03245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E8A47_RS03255	COG3115	cell septum assembly
E8A47_RS03260	COG1196	nuclear chromosome segregation
E8A47_RS03270	COG3088	subunit of a heme lyase
E8A47_RS03280	COG1138	Cytochrome C-type biogenesis protein
E8A47_RS03285	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E8A47_RS03305	COG4133	protoheme IX ABC transporter activity
E8A47_RS03315	COG1739	Uncharacterized protein family UPF0029
E8A47_RS03320	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
E8A47_RS03325	COG5016	pyruvate
E8A47_RS03325	COG0511	ligase activity, forming carbon-carbon bonds
E8A47_RS03330	COG3630	sodium ion export across plasma membrane
E8A47_RS03355	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E8A47_RS03360	COG0527	aspartate kinase activity
E8A47_RS03365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E8A47_RS03370	COG2137	regulation of response to DNA damage stimulus
E8A47_RS03375	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E8A47_RS03380	COG1546	Belongs to the CinA family
E8A47_RS03385	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E8A47_RS03390	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E8A47_RS03395	COG0148	phosphopyruvate hydratase activity
E8A47_RS03400	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E8A47_RS03405	COG0504	CTP synthase activity
E8A47_RS03410	COG0493	'glutamate synthase
E8A47_RS03415	COG0067	glutamate synthase
E8A47_RS03415	COG0069	glutamate synthase activity
E8A47_RS03415	COG0070	glutamate synthase
E8A47_RS03425	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E8A47_RS03475	COG1802	Transcriptional regulator
E8A47_RS03480	COG1960	acyl-CoA dehydrogenase activity
E8A47_RS03485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E8A47_RS03490	COG2200	EAL domain
E8A47_RS03490	COG2199	diguanylate cyclase activity
E8A47_RS03500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E8A47_RS03530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E8A47_RS03535	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E8A47_RS03540	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS03550	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E8A47_RS03555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E8A47_RS03560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E8A47_RS03580	COG3093	addiction module antidote protein HigA
E8A47_RS03590	COG1234	tRNA 3'-trailer cleavage
E8A47_RS03630	COG0517	IMP dehydrogenase activity
E8A47_RS03665	COG0006	proline dipeptidase activity
E8A47_RS03690	COG0747	negative chemotaxis
E8A47_RS03695	COG0601	transmembrane transport
E8A47_RS03700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E8A47_RS03710	COG0277	FAD linked oxidase domain protein
E8A47_RS03715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E8A47_RS03750	COG2423	ornithine cyclodeaminase activity
E8A47_RS03755	COG0251	oxidation-reduction process
E8A47_RS03765	COG0438	transferase activity, transferring glycosyl groups
E8A47_RS03775	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E8A47_RS03780	COG0343	queuine tRNA-ribosyltransferase activity
E8A47_RS03785	COG1862	Preprotein translocase
E8A47_RS03820	COG1104	cysteine desulfurase activity
E8A47_RS03825	COG0316	Belongs to the HesB IscA family
E8A47_RS03830	COG0105	UTP biosynthetic process
E8A47_RS03835	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E8A47_RS03850	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E8A47_RS03855	COG0124	histidyl-tRNA synthetase
E8A47_RS03860	COG2976	Protein conserved in bacteria
E8A47_RS03870	COG1160	GTP binding
E8A47_RS03895	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E8A47_RS03905	COG0009	L-threonylcarbamoyladenylate synthase
E8A47_RS03910	COG0758	DNA mediated transformation
E8A47_RS03920	COG0242	peptide deformylase activity
E8A47_RS03925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E8A47_RS03935	COG3360	Dodecin
E8A47_RS03940	COG0569	domain protein
E8A47_RS03945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E8A47_RS03955	COG3148	PFAM DTW domain containing protein
E8A47_RS03960	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E8A47_RS03965	COG0156	8-amino-7-oxononanoate synthase activity
E8A47_RS03970	COG0596	Alpha beta hydrolase
E8A47_RS03975	COG1073	alpha beta
E8A47_RS03975	COG2226	methyltransferase
E8A47_RS03980	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E8A47_RS03990	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E8A47_RS03995	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E8A47_RS04005	COG0531	amino acid
E8A47_RS04010	COG4302	ethanolamine ammonia-lyase activity
E8A47_RS04020	COG2207	Transcriptional regulator
E8A47_RS04025	COG2943	transferase activity, transferring hexosyl groups
E8A47_RS04045	COG2226	methyltransferase
E8A47_RS04090	COG1473	amidohydrolase
E8A47_RS04095	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E8A47_RS04110	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E8A47_RS04115	COG0564	pseudouridine synthase activity
E8A47_RS04155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E8A47_RS04160	COG0444	Belongs to the ABC transporter superfamily
E8A47_RS04165	COG4608	Belongs to the ABC transporter superfamily
E8A47_RS04185	COG1966	Carbon starvation protein
E8A47_RS04210	COG0795	lipopolysaccharide-transporting ATPase activity
E8A47_RS04215	COG0795	lipopolysaccharide-transporting ATPase activity
E8A47_RS04220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E8A47_RS04225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E8A47_RS04250	COG0525	valine-tRNA ligase activity
E8A47_RS04255	COG0038	chloride channel
E8A47_RS04285	COG4134	Bacterial extracellular solute-binding protein
E8A47_RS04290	COG4135	transport system, permease component
E8A47_RS04295	COG4136	ATPase activity
E8A47_RS04310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E8A47_RS04320	COG2203	Gaf domain
E8A47_RS04320	COG2199	diguanylate cyclase activity
E8A47_RS04335	COG0346	lactoylglutathione lyase activity
E8A47_RS04340	COG1988	membrane-bound metal-dependent
E8A47_RS04365	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E8A47_RS04380	COG0037	tRNA processing
E8A47_RS04385	COG0825	malonyl-CoA metabolic process
E8A47_RS04395	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E8A47_RS04400	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E8A47_RS04405	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E8A47_RS04410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E8A47_RS04415	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E8A47_RS04435	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E8A47_RS04440	COG0575	Belongs to the CDS family
E8A47_RS04445	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E8A47_RS04450	COG0233	cytoplasmic translational termination
E8A47_RS04455	COG0528	UMP kinase activity
E8A47_RS04460	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E8A47_RS04465	COG0052	Belongs to the universal ribosomal protein uS2 family
E8A47_RS04485	COG0436	Aminotransferase
E8A47_RS04500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E8A47_RS04520	COG0686	Belongs to the AlaDH PNT family
E8A47_RS04530	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E8A47_RS04535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E8A47_RS04540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E8A47_RS04545	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E8A47_RS04550	COG2003	Belongs to the UPF0758 family
E8A47_RS04555	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E8A47_RS04560	COG0756	dUTP diphosphatase activity
E8A47_RS04570	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E8A47_RS04575	COG1309	transcriptional regulator
E8A47_RS04585	COG2177	Part of the ABC transporter FtsEX involved in
E8A47_RS04590	COG2884	Cell division ATP-binding protein ftsE
E8A47_RS04595	COG0552	protein localization to endoplasmic reticulum
E8A47_RS04600	COG0742	ribosomal rna small subunit methyltransferase
E8A47_RS04610	COG0456	acetyltransferase
E8A47_RS04620	COG0271	Belongs to the BolA IbaG family
E8A47_RS04625	COG2814	Major facilitator Superfamily
E8A47_RS04635	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E8A47_RS04650	COG0789	Transcriptional regulator
E8A47_RS04655	COG2217	Heavy metal translocating P-type atpase
E8A47_RS04665	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E8A47_RS04680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E8A47_RS04685	COG4974	Belongs to the 'phage' integrase family
E8A47_RS04690	COG0335	large ribosomal subunit rRNA binding
E8A47_RS04695	COG0336	Belongs to the RNA methyltransferase TrmD family
E8A47_RS04700	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E8A47_RS04705	COG0228	four-way junction DNA binding
E8A47_RS04710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E8A47_RS04715	COG4137	Cytochrome C assembly protein
E8A47_RS04720	COG4536	flavin adenine dinucleotide binding
E8A47_RS04745	COG2925	Exonuclease
E8A47_RS04750	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E8A47_RS04755	COG2894	cell division
E8A47_RS04760	COG0850	regulation of cytokinetic process
E8A47_RS04770	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS04780	COG0583	DNA-binding transcription factor activity
E8A47_RS04795	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E8A47_RS04840	COG0667	Aldo Keto reductase
E8A47_RS04845	COG3022	response to hydroperoxide
E8A47_RS04880	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E8A47_RS04910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E8A47_RS04915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E8A47_RS04915	COG2813	Specifically methylates the guanine in position
E8A47_RS04925	COG1489	DNA binding
E8A47_RS04930	COG0436	Aminotransferase
E8A47_RS04935	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E8A47_RS04945	COG3852	Histidine kinase
E8A47_RS04950	COG2204	response regulator
E8A47_RS04955	COG0617	tRNA 3'-terminal CCA addition
E8A47_RS04970	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E8A47_RS04975	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E8A47_RS04980	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
E8A47_RS04995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E8A47_RS05010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E8A47_RS05015	COG0583	DNA-binding transcription factor activity
E8A47_RS05025	COG1185	polyribonucleotide nucleotidyltransferase activity
E8A47_RS05030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E8A47_RS05035	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E8A47_RS05040	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E8A47_RS05045	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E8A47_RS05050	COG0195	Participates in both transcription termination and antitermination
E8A47_RS05055	COG0779	Required for maturation of 30S ribosomal subunits
E8A47_RS05070	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E8A47_RS05075	COG0149	triose-phosphate isomerase activity
E8A47_RS05080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E8A47_RS05085	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E8A47_RS05090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E8A47_RS05095	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E8A47_RS05120	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E8A47_RS05135	COG4139	cobalamin transport
E8A47_RS05140	COG1120	ATPase activity
E8A47_RS05155	COG0484	heat shock protein binding
E8A47_RS05160	COG0443	Heat shock 70 kDa protein
E8A47_RS05165	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E8A47_RS05170	COG0497	DNA recombination
E8A47_RS05180	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E8A47_RS05185	COG2914	Belongs to the UPF0125 (RnfH) family
E8A47_RS05190	COG2867	negative regulation of translational initiation
E8A47_RS05195	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E8A47_RS05215	COG1733	regulation of RNA biosynthetic process
E8A47_RS05220	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS05235	COG0517	IMP dehydrogenase activity
E8A47_RS05250	COG0531	amino acid
E8A47_RS05265	COG3443	Belongs to the bacterial solute-binding protein 9 family
E8A47_RS05270	COG1278	Cold shock
E8A47_RS05295	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E8A47_RS05335	COG0840	transmembrane signaling receptor activity
E8A47_RS05340	COG1388	LysM domain
E8A47_RS05340	COG0791	NLP P60 protein
E8A47_RS05355	COG3639	organic phosphonate transmembrane transporter activity
E8A47_RS05360	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E8A47_RS05370	COG3300	MHYT domain
E8A47_RS05370	COG5001	Diguanylate cyclase
E8A47_RS05405	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E8A47_RS05410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E8A47_RS05415	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E8A47_RS05420	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E8A47_RS05425	COG0142	geranyltranstransferase activity
E8A47_RS05445	COG2176	DNA-directed DNA polymerase activity
E8A47_RS05525	COG4974	Belongs to the 'phage' integrase family
E8A47_RS05550	COG1598	PFAM Uncharacterised protein family UPF0150
E8A47_RS05560	COG2814	Major facilitator Superfamily
E8A47_RS05585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E8A47_RS05590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E8A47_RS05645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E8A47_RS05655	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS05660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E8A47_RS05690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E8A47_RS05695	COG0601	transmembrane transport
E8A47_RS05700	COG0747	negative chemotaxis
E8A47_RS05705	COG4172	Belongs to the ABC transporter superfamily
E8A47_RS05725	COG3012	SEC-C Motif Domain Protein
E8A47_RS05745	COG1175	transmembrane transport
E8A47_RS05755	COG3842	ATPase activity
E8A47_RS05760	COG4941	Belongs to the sigma-70 factor family
E8A47_RS05765	COG0667	Aldo Keto reductase
E8A47_RS05770	COG0583	DNA-binding transcription factor activity
E8A47_RS05780	COG3795	YCII-related domain
E8A47_RS05785	COG5507	3-demethylubiquinone-9 3-methyltransferase
E8A47_RS05790	COG0737	Belongs to the 5'-nucleotidase family
E8A47_RS05805	COG0671	phosphoesterase, PA-phosphatase related
E8A47_RS05810	COG5510	response to toxic substance
E8A47_RS05825	COG2204	response regulator
E8A47_RS05865	COG0501	Belongs to the peptidase M48B family
E8A47_RS05920	COG1121	(ABC) transporter
E8A47_RS05930	COG0803	Belongs to the bacterial solute-binding protein 9 family
E8A47_RS05970	COG0352	thiamine-phosphate diphosphorylase activity
E8A47_RS05975	COG0583	DNA-binding transcription factor activity
E8A47_RS05985	COG3384	dioxygenase
E8A47_RS05990	COG0826	peptidase U32
E8A47_RS06000	COG1686	Belongs to the peptidase S11 family
E8A47_RS06005	COG0203	ribosomal protein L17
E8A47_RS06010	COG0202	RNA polymerase activity
E8A47_RS06015	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E8A47_RS06020	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E8A47_RS06025	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E8A47_RS06030	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E8A47_RS06040	COG0200	Binds to the 23S rRNA
E8A47_RS06045	COG1841	ribosomal large subunit assembly
E8A47_RS06050	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E8A47_RS06055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E8A47_RS06060	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E8A47_RS06065	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E8A47_RS06070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E8A47_RS06075	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E8A47_RS06080	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E8A47_RS06085	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E8A47_RS06090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E8A47_RS06095	COG0255	Belongs to the universal ribosomal protein uL29 family
E8A47_RS06100	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E8A47_RS06105	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E8A47_RS06110	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E8A47_RS06115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E8A47_RS06120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E8A47_RS06125	COG0089	rRNA binding
E8A47_RS06130	COG0088	Forms part of the polypeptide exit tunnel
E8A47_RS06135	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E8A47_RS06140	COG0051	transcription antitermination factor activity, RNA binding
E8A47_RS06145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E8A47_RS06150	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E8A47_RS06160	COG0049	tRNA binding
E8A47_RS06165	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E8A47_RS06170	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E8A47_RS06175	COG0085	RNA polymerase activity
E8A47_RS06180	COG0222	ribosome binding
E8A47_RS06185	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E8A47_RS06190	COG0081	regulation of translation
E8A47_RS06195	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E8A47_RS06230	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E8A47_RS06235	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E8A47_RS06235	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E8A47_RS06245	COG0733	neurotransmitter:sodium symporter activity
E8A47_RS06285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E8A47_RS06290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E8A47_RS06295	COG1090	epimerase
E8A47_RS06320	COG0300	oxidoreductase activity
E8A47_RS06335	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E8A47_RS06350	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E8A47_RS06375	COG3693	PFAM glycoside hydrolase, family 10
E8A47_RS06380	COG0629	single-stranded DNA binding
E8A47_RS06385	COG2814	Major facilitator Superfamily
E8A47_RS06395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E8A47_RS06425	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E8A47_RS06450	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E8A47_RS06465	COG0745	RESPONSE REGULATOR receiver
E8A47_RS06470	COG0840	transmembrane signaling receptor activity
E8A47_RS06475	COG2201	protein-glutamate methylesterase activity
E8A47_RS06480	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E8A47_RS06485	COG0840	transmembrane signaling receptor activity
E8A47_RS06490	COG0840	transmembrane signaling receptor activity
E8A47_RS06495	COG0835	chemotaxis
E8A47_RS06500	COG2198	Histidine kinase
E8A47_RS06500	COG0643	Histidine kinase
E8A47_RS06505	COG1360	Flagellar Motor Protein
E8A47_RS06525	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E8A47_RS06545	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
E8A47_RS06550	COG1334	flagellar protein FlaG
E8A47_RS06555	COG1677	Flagellar hook-basal body complex protein FliE
E8A47_RS06560	COG1766	The M ring may be actively involved in energy transduction
E8A47_RS06580	COG2882	bacterial-type flagellum organization
E8A47_RS06605	COG3190	flagellar
E8A47_RS06615	COG1987	bacterial-type flagellum assembly
E8A47_RS06630	COG1256	bacterial-type flagellum assembly
E8A47_RS06635	COG3951	Flagellar rod assembly protein muramidase FlgJ
E8A47_RS06635	COG1705	Flagellar rod assembly protein muramidase FlgJ
E8A47_RS06640	COG1706	bacterial-type flagellum-dependent cell motility
E8A47_RS06670	COG1558	bacterial-type flagellum-dependent cell motility
E8A47_RS06725	COG1304	FMN binding
E8A47_RS06750	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E8A47_RS06755	COG0733	neurotransmitter:sodium symporter activity
E8A47_RS06760	COG0339	signal peptide processing
E8A47_RS06780	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E8A47_RS06790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E8A47_RS06795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E8A47_RS06800	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E8A47_RS06810	COG1346	cytolysis
E8A47_RS06815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E8A47_RS06820	COG0126	phosphoglycerate kinase activity
E8A47_RS06840	COG0546	phosphoglycolate phosphatase activity
E8A47_RS06845	COG0023	Translation Initiation Factor
E8A47_RS06880	COG0540	Belongs to the ATCase OTCase family
E8A47_RS06885	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E8A47_RS06890	COG1678	Uncharacterized ACR, COG1678
E8A47_RS06895	COG0189	ligase activity
E8A47_RS06900	COG2996	Protein conserved in bacteria
E8A47_RS06905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E8A47_RS06915	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E8A47_RS06920	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E8A47_RS06925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E8A47_RS06930	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E8A47_RS06935	COG4942	peptidase
E8A47_RS06940	COG0793	Belongs to the peptidase S41A family
E8A47_RS06945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E8A47_RS06950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E8A47_RS06955	COG0006	proline dipeptidase activity
E8A47_RS06975	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E8A47_RS06980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E8A47_RS06985	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E8A47_RS06990	COG1519	Transferase
E8A47_RS06995	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E8A47_RS06995	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E8A47_RS07010	COG3307	-O-antigen
E8A47_RS07015	COG1442	glycosyl transferase family 8
E8A47_RS07020	COG0438	transferase activity, transferring glycosyl groups
E8A47_RS07025	COG0463	Glycosyl transferase, family 2
E8A47_RS07030	COG0438	transferase activity, transferring glycosyl groups
E8A47_RS07050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E8A47_RS07055	COG0752	glycyl-tRNA synthetase alpha subunit
E8A47_RS07060	COG0751	glycine-tRNA ligase activity
E8A47_RS07075	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E8A47_RS07085	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E8A47_RS07090	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E8A47_RS07095	COG0594	ribonuclease P activity
E8A47_RS07100	COG0706	membrane insertase activity
E8A47_RS07105	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E8A47_RS07110	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E8A47_RS07115	COG2885	chlorophyll binding
E8A47_RS07120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E8A47_RS07165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E8A47_RS07170	COG0351	phosphomethylpyrimidine kinase
E8A47_RS07175	COG1981	membrane
E8A47_RS07185	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E8A47_RS07190	COG0316	Belongs to the HesB IscA family
E8A47_RS07195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E8A47_RS07200	COG0765	amino acid transport
E8A47_RS07210	COG0445	tRNA wobble uridine modification
E8A47_RS07215	COG0357	Ribosomal RNA small subunit methyltransferase G
E8A47_RS07220	COG1192	Involved in chromosome partitioning
E8A47_RS07225	COG1475	DNA binding
E8A47_RS07235	COG0356	it plays a direct role in the translocation of protons across the membrane
E8A47_RS07245	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E8A47_RS07250	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E8A47_RS07255	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E8A47_RS07260	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E8A47_RS07265	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E8A47_RS07270	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E8A47_RS07275	COG2239	Acts as a magnesium transporter
E8A47_RS07285	COG1968	undecaprenyl-diphosphatase activity
E8A47_RS07295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E8A47_RS07305	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E8A47_RS07325	COG0456	acetyltransferase
E8A47_RS07335	COG0210	DNA helicase
E8A47_RS07340	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E8A47_RS07345	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E8A47_RS07355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E8A47_RS07365	COG1070	Carbohydrate kinase
E8A47_RS07370	COG1172	Belongs to the binding-protein-dependent transport system permease family
E8A47_RS07375	COG1172	Belongs to the binding-protein-dependent transport system permease family
E8A47_RS07380	COG1129	ABC transporter
E8A47_RS07395	COG1561	YicC-like family, N-terminal region
E8A47_RS07415	COG0730	response to heat
E8A47_RS07455	COG2814	Major facilitator Superfamily
E8A47_RS07470	COG0194	GDP metabolic process
E8A47_RS07475	COG1758	RNA polymerase activity
E8A47_RS07480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E8A47_RS07495	COG0583	DNA-binding transcription factor activity
E8A47_RS07500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E8A47_RS07505	COG1289	transmembrane transporter activity
E8A47_RS07520	COG1473	amidohydrolase
E8A47_RS07530	COG1012	belongs to the aldehyde dehydrogenase family
E8A47_RS07535	COG0583	DNA-binding transcription factor activity
E8A47_RS07550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E8A47_RS07555	COG3161	chorismate lyase activity
E8A47_RS07560	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E8A47_RS07600	COG0704	Plays a role in the regulation of phosphate uptake
E8A47_RS07605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E8A47_RS07610	COG0581	inorganic phosphate transmembrane transporter activity
E8A47_RS07630	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E8A47_RS07635	COG0210	DNA helicase
E8A47_RS07640	COG1737	Transcriptional regulator
E8A47_RS07650	COG0733	neurotransmitter:sodium symporter activity
E8A47_RS07655	COG1801	Protein of unknown function DUF72
E8A47_RS07660	COG5383	Protein conserved in bacteria
E8A47_RS07670	COG1414	Transcriptional regulator
E8A47_RS07675	COG3181	Tripartite tricarboxylate transporter family receptor
E8A47_RS07690	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS07695	COG0679	Auxin Efflux Carrier
E8A47_RS07700	COG3185	4-Hydroxyphenylpyruvate dioxygenase
E8A47_RS07700	COG1082	Xylose isomerase domain protein TIM barrel
E8A47_RS07710	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS07725	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS07735	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS07745	COG1082	Xylose isomerase domain protein TIM barrel
E8A47_RS07745	COG3185	4-Hydroxyphenylpyruvate dioxygenase
E8A47_RS07770	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E8A47_RS07775	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS07780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS07785	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS07800	COG1802	Transcriptional regulator
E8A47_RS07805	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E8A47_RS07810	COG1082	Xylose isomerase domain protein TIM barrel
E8A47_RS07810	COG3185	4-Hydroxyphenylpyruvate dioxygenase
E8A47_RS07815	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS07825	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS07840	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E8A47_RS07845	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E8A47_RS07855	COG0596	Alpha beta hydrolase
E8A47_RS07860	COG3485	protocatechuate 3,4-dioxygenase
E8A47_RS07865	COG3485	protocatechuate 3,4-dioxygenase
E8A47_RS07875	COG3501	Rhs element vgr protein
E8A47_RS07930	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS07945	COG1802	Transcriptional regulator
E8A47_RS07955	COG3320	Male sterility
E8A47_RS07955	COG1022	Amp-dependent synthetase and ligase
E8A47_RS07980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS07985	COG1024	Enoyl-CoA hydratase
E8A47_RS07990	COG1012	belongs to the aldehyde dehydrogenase family
E8A47_RS07995	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS08000	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E8A47_RS08015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS08020	COG1012	belongs to the aldehyde dehydrogenase family
E8A47_RS08025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS08055	COG2828	Protein conserved in bacteria
E8A47_RS08060	COG0583	DNA-binding transcription factor activity
E8A47_RS08090	COG0154	amidase activity
E8A47_RS08105	COG4638	Rieske (2fe-2S)
E8A47_RS08115	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS08135	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E8A47_RS08145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E8A47_RS08165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E8A47_RS08190	COG0840	transmembrane signaling receptor activity
E8A47_RS08205	COG1012	belongs to the aldehyde dehydrogenase family
E8A47_RS08220	COG1250	3-hydroxyacyl-CoA dehydrogenase
E8A47_RS08225	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS08235	COG1846	Transcriptional regulator
E8A47_RS08240	COG0471	metal ion transport
E8A47_RS08245	COG3246	L-lysine catabolic process to acetate
E8A47_RS08250	COG4948	Mandelate Racemase Muconate Lactonizing
E8A47_RS08255	COG4829	muconolactone delta-isomerase
E8A47_RS08270	COG1970	mechanosensitive ion channel activity
E8A47_RS08290	COG0181	hydroxymethylbilane synthase activity
E8A47_RS08300	COG0165	Argininosuccinate lyase
E8A47_RS08305	COG0019	diaminopimelate decarboxylase activity
E8A47_RS08310	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E8A47_RS08320	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E8A47_RS08325	COG1011	Hydrolase
E8A47_RS08330	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E8A47_RS08355	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS08360	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E8A47_RS08375	COG1490	D-aminoacyl-tRNA deacylase activity
E8A47_RS08380	COG0488	(ABC) transporter
E8A47_RS08390	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS08395	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E8A47_RS08400	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS08405	COG0589	response to stress
E8A47_RS08410	COG0545	Peptidyl-prolyl cis-trans isomerase
E8A47_RS08420	COG1999	signal sequence binding
E8A47_RS08440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E8A47_RS08460	COG3181	Tripartite tricarboxylate transporter family receptor
E8A47_RS08475	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E8A47_RS08490	COG2363	Small membrane protein
E8A47_RS08495	COG2194	sulfuric ester hydrolase activity
E8A47_RS08505	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E8A47_RS08510	COG0859	PFAM glycosyl transferase family 9
E8A47_RS08535	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E8A47_RS08545	COG0583	DNA-binding transcription factor activity
E8A47_RS08550	COG0655	NAD(P)H dehydrogenase (quinone) activity
E8A47_RS08605	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E8A47_RS08620	COG0789	Transcriptional regulator
E8A47_RS08640	COG2002	toxin-antitoxin pair type II binding
E8A47_RS08650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E8A47_RS08680	COG0004	ammonium transporteR
E8A47_RS08695	COG0583	DNA-binding transcription factor activity
E8A47_RS08700	COG0840	transmembrane signaling receptor activity
E8A47_RS08720	COG3639	organic phosphonate transmembrane transporter activity
E8A47_RS08740	COG3706	GGDEF domain
E8A47_RS08745	COG0251	oxidation-reduction process
E8A47_RS08750	COG1126	abc transporter atp-binding protein
E8A47_RS08755	COG0765	amino acid transport
E8A47_RS08760	COG4597	amino acid ABC transporter
E8A47_RS08765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E8A47_RS08770	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E8A47_RS08775	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E8A47_RS08780	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E8A47_RS08785	COG1272	protein, Hemolysin III
E8A47_RS08810	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E8A47_RS08815	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E8A47_RS08820	COG0142	geranyltranstransferase activity
E8A47_RS08825	COG1722	exodeoxyribonuclease VII activity
E8A47_RS08830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E8A47_RS08835	COG1741	Belongs to the pirin family
E8A47_RS08840	COG1054	Belongs to the UPF0176 family
E8A47_RS08855	COG1238	metal cluster binding
E8A47_RS08860	COG0668	transmembrane transport
E8A47_RS08865	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS08870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E8A47_RS08895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS08915	COG0583	DNA-binding transcription factor activity
E8A47_RS08920	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E8A47_RS08925	COG0277	FAD linked oxidase domain protein
E8A47_RS08925	COG0247	lactate metabolic process
E8A47_RS08930	COG5383	Protein conserved in bacteria
E8A47_RS08935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E8A47_RS08940	COG1757	Na H antiporter
E8A47_RS08945	COG1012	belongs to the aldehyde dehydrogenase family
E8A47_RS08950	COG0583	DNA-binding transcription factor activity
E8A47_RS08955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E8A47_RS08960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E8A47_RS08965	COG1116	anion transmembrane transporter activity
E8A47_RS08970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E8A47_RS08980	COG3290	protein histidine kinase activity
E8A47_RS08985	COG4565	transcriptional regulatory protein
E8A47_RS09030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E8A47_RS09035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E8A47_RS09035	COG1321	iron dependent repressor
E8A47_RS09040	COG1121	(ABC) transporter
E8A47_RS09045	COG0803	Belongs to the bacterial solute-binding protein 9 family
E8A47_RS09050	COG3706	GGDEF domain
E8A47_RS09055	COG0829	nickel cation binding
E8A47_RS09060	COG0831	urea catabolic process
E8A47_RS09065	COG0832	Belongs to the urease beta subunit family
E8A47_RS09070	COG0804	urea catabolic process
E8A47_RS09075	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
E8A47_RS09080	COG0830	nickel cation binding
E8A47_RS09085	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E8A47_RS09090	COG1959	2 iron, 2 sulfur cluster binding
E8A47_RS09090	COG1295	ribonuclease BN
E8A47_RS09105	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E8A47_RS09110	COG3383	formate dehydrogenase (NAD+) activity
E8A47_RS09130	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS09150	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E8A47_RS09150	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS09155	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E8A47_RS09155	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS09160	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS09165	COG0277	FAD linked oxidase domain protein
E8A47_RS09175	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS09215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E8A47_RS09225	COG2188	Transcriptional regulator
E8A47_RS09305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E8A47_RS09310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E8A47_RS09325	COG0840	transmembrane signaling receptor activity
E8A47_RS09335	COG2351	hydroxyisourate hydrolase activity
E8A47_RS09350	COG1414	Transcriptional regulator
E8A47_RS09355	COG3257	ureidoglycine aminohydrolase activity
E8A47_RS09360	COG3960	tartronate-semialdehyde synthase activity
E8A47_RS09365	COG3622	Belongs to the hyi family
E8A47_RS09370	COG2084	Dehydrogenase
E8A47_RS09380	COG0469	pyruvate kinase activity
E8A47_RS09400	COG3195	allantoin biosynthetic process
E8A47_RS09400	COG3648	Uricase
E8A47_RS09425	COG2801	Transposase and inactivated derivatives
E8A47_RS09430	COG0583	DNA-binding transcription factor activity
E8A47_RS09435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E8A47_RS09440	COG4597	amino acid ABC transporter
E8A47_RS09445	COG0765	amino acid transport
E8A47_RS09450	COG1126	abc transporter atp-binding protein
E8A47_RS09455	COG1446	asparaginase
E8A47_RS09465	COG1230	cation diffusion facilitator family transporter
E8A47_RS09470	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E8A47_RS09490	COG4789	Type iii secretion
E8A47_RS09495	COG4964	Belongs to the GSP D family
E8A47_RS09550	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E8A47_RS09555	COG4790	Type iii secretion
E8A47_RS09560	COG4794	Type iii secretion
E8A47_RS09565	COG4791	protein targeting
E8A47_RS09575	COG4792	protein secretion
E8A47_RS09595	COG0625	glutathione transferase activity
E8A47_RS09605	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS09615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS09625	COG3386	PFAM SMP-30 Gluconolaconase
E8A47_RS09630	COG2084	Dehydrogenase
E8A47_RS09645	COG1012	belongs to the aldehyde dehydrogenase family
E8A47_RS09655	COG1053	succinate dehydrogenase
E8A47_RS09665	COG1414	Transcriptional regulator
E8A47_RS09690	COG1522	sequence-specific DNA binding
E8A47_RS09700	COG0733	neurotransmitter:sodium symporter activity
E8A47_RS09705	COG1522	sequence-specific DNA binding
E8A47_RS09715	COG2814	Major facilitator Superfamily
E8A47_RS09720	COG0625	glutathione transferase activity
E8A47_RS09730	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E8A47_RS09740	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E8A47_RS09740	COG0446	pyridine nucleotide-disulphide oxidoreductase
E8A47_RS09750	COG1846	Transcriptional regulator
E8A47_RS09770	COG1012	belongs to the aldehyde dehydrogenase family
E8A47_RS09770	COG2030	dehydratase
E8A47_RS09775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E8A47_RS09780	COG2151	metal-sulfur cluster biosynthetic enzyme
E8A47_RS09785	COG3396	Phenylacetate-CoA oxygenase
E8A47_RS09790	COG3460	Phenylacetate-CoA oxygenase
E8A47_RS09795	COG3396	Phenylacetate-CoA oxygenase
E8A47_RS09805	COG2050	protein possibly involved in aromatic compounds catabolism
E8A47_RS09815	COG1024	Enoyl-CoA hydratase
E8A47_RS09850	COG1132	(ABC) transporter
E8A47_RS09875	COG3284	Transcriptional regulator
E8A47_RS09880	COG3327	negative regulation of DNA-templated transcription, initiation
E8A47_RS09885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E8A47_RS09890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E8A47_RS09910	COG1757	Na H antiporter
E8A47_RS09920	COG1280	lysine exporter protein (LysE YggA)
E8A47_RS09945	COG1902	pentaerythritol trinitrate reductase activity
E8A47_RS09945	COG0446	pyridine nucleotide-disulphide oxidoreductase
E8A47_RS09950	COG0247	lactate metabolic process
E8A47_RS09950	COG2181	nitrate reductase activity
E8A47_RS09955	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E8A47_RS09965	COG0697	spore germination
E8A47_RS09975	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E8A47_RS09980	COG1063	alcohol dehydrogenase
E8A47_RS09990	COG3383	formate dehydrogenase (NAD+) activity
E8A47_RS09995	COG0446	pyridine nucleotide-disulphide oxidoreductase
E8A47_RS09995	COG1902	pentaerythritol trinitrate reductase activity
E8A47_RS10010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E8A47_RS10015	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E8A47_RS10030	COG0446	pyridine nucleotide-disulphide oxidoreductase
E8A47_RS10030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E8A47_RS10045	COG1760	l-serine dehydratase
E8A47_RS10055	COG1294	oxidase, subunit
E8A47_RS10060	COG1271	oxidase subunit
E8A47_RS10065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E8A47_RS10070	COG0348	domain, Protein
E8A47_RS10085	COG1121	(ABC) transporter
E8A47_RS10090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E8A47_RS10105	COG0523	cobalamin synthesis protein
E8A47_RS10110	COG1469	GTP cyclohydrolase I activity
E8A47_RS10130	COG3485	protocatechuate 3,4-dioxygenase
E8A47_RS10150	COG0778	Nitroreductase
E8A47_RS10155	COG2873	o-acetylhomoserine
E8A47_RS10160	COG0010	Belongs to the arginase family
E8A47_RS10175	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E8A47_RS10200	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E8A47_RS10205	COG1132	(ABC) transporter
E8A47_RS10210	COG0667	Aldo Keto reductase
E8A47_RS10215	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E8A47_RS10260	COG2010	Cytochrome c
E8A47_RS10260	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E8A47_RS10265	COG1846	Transcriptional regulator
E8A47_RS10270	COG1335	isochorismatase
E8A47_RS10275	COG3473	Maleate cis-trans isomerase
E8A47_RS10280	COG0596	Alpha beta hydrolase
E8A47_RS10290	COG2080	2 iron, 2 sulfur cluster binding
E8A47_RS10295	COG2010	Cytochrome c
E8A47_RS10295	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E8A47_RS10305	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E8A47_RS10310	COG2309	aminopeptidase activity
E8A47_RS10315	COG1984	allophanate hydrolase subunit 2
E8A47_RS10320	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E8A47_RS10325	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E8A47_RS10330	COG0583	DNA-binding transcription factor activity
E8A47_RS10345	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS10365	COG2188	Transcriptional regulator
E8A47_RS10370	COG1840	ABC-type Fe3 transport system, periplasmic component
E8A47_RS10375	COG3842	ATPase activity
E8A47_RS10385	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E8A47_RS10390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E8A47_RS10410	COG3501	Rhs element vgr protein
E8A47_RS10420	COG3718	enzyme involved in inositol metabolism
E8A47_RS10425	COG0673	inositol 2-dehydrogenase activity
E8A47_RS10455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E8A47_RS10460	COG3962	Belongs to the TPP enzyme family
E8A47_RS10480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E8A47_RS10505	COG4221	oxidoreductase activity
E8A47_RS10515	COG2239	Acts as a magnesium transporter
E8A47_RS10520	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E8A47_RS10525	COG1522	sequence-specific DNA binding
E8A47_RS10530	COG2832	Protein of unknown function (DUF454)
E8A47_RS10540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E8A47_RS10545	COG4558	Periplasmic binding protein
E8A47_RS10550	COG3720	iron ion transport
E8A47_RS10555	COG4771	TonB-dependent receptor
E8A47_RS10575	COG0583	DNA-binding transcription factor activity
E8A47_RS10585	COG0702	epimerase
E8A47_RS10590	COG0583	DNA-binding transcription factor activity
E8A47_RS10595	COG2186	Transcriptional regulator
E8A47_RS10605	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS10615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS10630	COG1609	Transcriptional regulator
E8A47_RS10635	COG2084	Dehydrogenase
E8A47_RS10640	COG3395	kinase activity
E8A47_RS10645	COG0235	Class ii aldolase
E8A47_RS10650	COG3622	Belongs to the hyi family
E8A47_RS10655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E8A47_RS10660	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS10670	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E8A47_RS10670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS10675	COG1012	belongs to the aldehyde dehydrogenase family
E8A47_RS10680	COG2084	Dehydrogenase
E8A47_RS10685	COG1309	transcriptional regulator
E8A47_RS10695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E8A47_RS10705	COG4221	oxidoreductase activity
E8A47_RS10710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E8A47_RS10715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E8A47_RS10720	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E8A47_RS10725	COG0765	amino acid transport
E8A47_RS10730	COG4215	(ABC) transporter
E8A47_RS10740	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
E8A47_RS10745	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS10755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS10760	COG0583	DNA-binding transcription factor activity
E8A47_RS10770	COG1960	acyl-CoA dehydrogenase activity
E8A47_RS10800	COG0488	(ABC) transporter
E8A47_RS10820	COG1012	belongs to the aldehyde dehydrogenase family
E8A47_RS10830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E8A47_RS10835	COG1757	Na H antiporter
E8A47_RS10840	COG2957	Belongs to the agmatine deiminase family
E8A47_RS10845	COG1902	pentaerythritol trinitrate reductase activity
E8A47_RS10865	COG1288	antiporter activity
E8A47_RS10875	COG0006	proline dipeptidase activity
E8A47_RS10880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E8A47_RS10885	COG0174	glutamine synthetase
E8A47_RS10890	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E8A47_RS10900	COG1012	belongs to the aldehyde dehydrogenase family
E8A47_RS10905	COG1757	Na H antiporter
E8A47_RS10925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E8A47_RS10930	COG0531	amino acid
E8A47_RS10935	COG1012	belongs to the aldehyde dehydrogenase family
E8A47_RS10940	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E8A47_RS10955	COG2329	Antibiotic biosynthesis monooxygenase
E8A47_RS10960	COG1575	Belongs to the MenA family. Type 1 subfamily
E8A47_RS10970	COG1169	isochorismate synthase
E8A47_RS10975	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E8A47_RS10980	COG0596	Alpha beta hydrolase
E8A47_RS10990	COG1053	succinate dehydrogenase
E8A47_RS10995	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E8A47_RS11005	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
E8A47_RS11015	COG1441	menaquinone biosynthetic process
E8A47_RS11020	COG0318	PFAM AMP-dependent synthetase and ligase
E8A47_RS11040	COG1309	transcriptional regulator
E8A47_RS11045	COG1522	sequence-specific DNA binding
E8A47_RS11050	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E8A47_RS11055	COG1280	lysine exporter protein (LysE YggA)
E8A47_RS11100	COG1120	ATPase activity
E8A47_RS11105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E8A47_RS11110	COG1830	Aldolase
E8A47_RS11125	COG0071	Belongs to the small heat shock protein (HSP20) family
E8A47_RS11130	COG0384	phenazine biosynthesis protein PhzF
E8A47_RS11140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E8A47_RS11155	COG2818	Glycosylase
E8A47_RS11180	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E8A47_RS11185	COG0402	S-adenosylhomocysteine deaminase activity
E8A47_RS11190	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E8A47_RS11195	COG5001	Diguanylate cyclase
E8A47_RS11195	COG3300	MHYT domain
E8A47_RS11205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E8A47_RS11225	COG0840	transmembrane signaling receptor activity
E8A47_RS11230	COG4607	ABC-type enterochelin transport system periplasmic component
E8A47_RS11255	COG1953	Uracil, thiamine, allantoin
E8A47_RS11270	COG0523	cobalamin synthesis protein
E8A47_RS11275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E8A47_RS11280	COG0303	'Molybdopterin
E8A47_RS11285	COG0746	molybdenum cofactor guanylyltransferase activity
E8A47_RS11290	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E8A47_RS11320	COG3383	formate dehydrogenase (NAD+) activity
E8A47_RS11325	COG0437	4 iron, 4 sulfur cluster binding
E8A47_RS11340	COG0521	Mo-molybdopterin cofactor biosynthetic process
E8A47_RS11345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E8A47_RS11355	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E8A47_RS11400	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E8A47_RS11410	COG0840	transmembrane signaling receptor activity
E8A47_RS11415	COG0754	glutathionylspermidine amidase activity
E8A47_RS11445	COG0318	PFAM AMP-dependent synthetase and ligase
E8A47_RS11465	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS11475	COG0154	amidase activity
E8A47_RS11480	COG4977	sequence-specific DNA binding
E8A47_RS11485	COG2814	Major facilitator Superfamily
E8A47_RS11495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E8A47_RS11505	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E8A47_RS11515	COG1349	DNA-binding transcription factor activity
E8A47_RS11520	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E8A47_RS11530	COG3706	GGDEF domain
E8A47_RS11530	COG2203	Gaf domain
E8A47_RS11530	COG5001	Diguanylate cyclase
E8A47_RS11530	COG4251	negative regulation of phosphorylation
E8A47_RS11540	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
E8A47_RS11545	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
E8A47_RS11550	COG0235	Class ii aldolase
E8A47_RS11560	COG5654	RES domain protein
E8A47_RS11570	COG0514	ATP-dependent DNA helicase (RecQ)
E8A47_RS11585	COG0395	ABC-type sugar transport system, permease component
E8A47_RS11590	COG1175	transmembrane transport
E8A47_RS11595	COG1653	transport
E8A47_RS11605	COG3829	transcription factor binding
E8A47_RS11605	COG3290	protein histidine kinase activity
E8A47_RS11615	COG3314	Sporulation integral membrane protein YlbJ
E8A47_RS11625	COG1012	belongs to the aldehyde dehydrogenase family
E8A47_RS11630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E8A47_RS11635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E8A47_RS11640	COG0583	DNA-binding transcription factor activity
E8A47_RS11645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS11655	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS11665	COG0277	FAD linked oxidase domain protein
E8A47_RS11670	COG4948	Mandelate Racemase Muconate Lactonizing
E8A47_RS11680	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS11685	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E8A47_RS11690	COG3395	kinase activity
E8A47_RS11695	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS11700	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E8A47_RS11705	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS11710	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E8A47_RS11715	COG2186	Transcriptional regulator
E8A47_RS11720	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS11725	COG0129	dihydroxy-acid dehydratase activity
E8A47_RS11745	COG2084	Dehydrogenase
E8A47_RS11750	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E8A47_RS11755	COG2084	Dehydrogenase
E8A47_RS11765	COG2721	sulfolactate sulfo-lyase activity
E8A47_RS11840	COG1129	ABC transporter
E8A47_RS11865	COG1846	Transcriptional regulator
E8A47_RS11865	COG1940	carbohydrate kinase activity
E8A47_RS11875	COG1172	Belongs to the binding-protein-dependent transport system permease family
E8A47_RS11880	COG1879	ABC-type sugar transport system periplasmic component
E8A47_RS11890	COG0673	inositol 2-dehydrogenase activity
E8A47_RS11895	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS11900	COG1653	transport
E8A47_RS11905	COG1175	transmembrane transport
E8A47_RS11910	COG0395	ABC-type sugar transport system, permease component
E8A47_RS11925	COG0477	Major facilitator Superfamily
E8A47_RS11945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E8A47_RS11950	COG1131	(ABC) transporter
E8A47_RS11955	COG0842	Transport permease protein
E8A47_RS11975	COG3932	Exopolysaccharide synthesis, ExoD
E8A47_RS11980	COG0517	IMP dehydrogenase activity
E8A47_RS11985	COG4974	Belongs to the 'phage' integrase family
E8A47_RS12010	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E8A47_RS12015	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E8A47_RS12030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E8A47_RS12065	COG1126	abc transporter atp-binding protein
E8A47_RS12075	COG0268	Binds directly to 16S ribosomal RNA
E8A47_RS12085	COG0196	riboflavin kinase activity
E8A47_RS12090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E8A47_RS12100	COG1047	Peptidyl-prolyl cis-trans
E8A47_RS12105	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E8A47_RS12130	COG0180	Tryptophanyl-tRNA synthetase
E8A47_RS12190	COG3829	transcription factor binding
E8A47_RS12215	COG3501	Rhs element vgr protein
E8A47_RS12250	COG5444	nuclease activity
E8A47_RS12295	COG2391	methyltransferase activity
E8A47_RS12300	COG0281	malic enzyme
E8A47_RS12310	COG0492	ferredoxin-NADP+ reductase activity
E8A47_RS12315	COG4969	Belongs to the N-Me-Phe pilin family
E8A47_RS12330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E8A47_RS12330	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E8A47_RS12340	COG0840	transmembrane signaling receptor activity
E8A47_RS12365	COG2814	Major facilitator Superfamily
E8A47_RS12370	COG0028	Belongs to the TPP enzyme family
E8A47_RS12375	COG0440	acetolactate synthase activity
E8A47_RS12380	COG1183	phosphatidylcholine synthase activity
E8A47_RS12400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E8A47_RS12410	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E8A47_RS12415	COG0709	Synthesizes selenophosphate from selenide and ATP
E8A47_RS12420	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E8A47_RS12430	COG3068	Protein conserved in bacteria
E8A47_RS12440	COG0107	imidazoleglycerol-phosphate synthase activity
E8A47_RS12445	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E8A47_RS12450	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E8A47_RS12455	COG0131	Imidazoleglycerol-phosphate dehydratase
E8A47_RS12470	COG1194	a g-specific adenine glycosylase
E8A47_RS12475	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E8A47_RS12545	COG1280	lysine exporter protein (LysE YggA)
E8A47_RS12555	COG5285	phytanoyl-CoA dioxygenase
E8A47_RS12560	COG0179	Fumarylacetoacetate (FAA) hydrolase
E8A47_RS12565	COG1166	arginine decarboxylase activity
E8A47_RS12585	COG1294	oxidase, subunit
E8A47_RS12595	COG4988	ABC transporter
E8A47_RS12600	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E8A47_RS12605	COG1840	ABC-type Fe3 transport system, periplasmic component
E8A47_RS12610	COG3842	ATPase activity
E8A47_RS12615	COG1178	ABC-type Fe3 transport system permease component
E8A47_RS12620	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS12630	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E8A47_RS12635	COG1444	tRNA N-acetyltransferase activity
E8A47_RS12640	COG2195	Cleaves the N-terminal amino acid of tripeptides
E8A47_RS12645	COG0783	Belongs to the Dps family
E8A47_RS12650	COG1929	Belongs to the glycerate kinase type-1 family
E8A47_RS12695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E8A47_RS12705	COG1607	acyl-coa hydrolase
E8A47_RS12710	COG2031	fatty acid transporter
E8A47_RS12715	COG0534	Mate efflux family protein
E8A47_RS12720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E8A47_RS12725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E8A47_RS12735	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E8A47_RS12750	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E8A47_RS12775	COG3706	GGDEF domain
E8A47_RS12795	COG3577	Aspartyl protease
E8A47_RS12805	COG0745	RESPONSE REGULATOR receiver
E8A47_RS12810	COG2205	protein histidine kinase activity
E8A47_RS12815	COG0583	DNA-binding transcription factor activity
E8A47_RS12820	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E8A47_RS12835	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E8A47_RS12845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E8A47_RS12850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E8A47_RS12855	COG0140	phosphoribosyl-ATP diphosphatase activity
E8A47_RS12860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E8A47_RS12880	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E8A47_RS12885	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E8A47_RS12895	COG0018	arginyl-trna synthetase
E8A47_RS12900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E8A47_RS12905	COG0254	rRNA binding
E8A47_RS12910	COG0281	malic enzyme
E8A47_RS12915	COG1946	Acyl-CoA thioesterase
E8A47_RS12925	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E8A47_RS12930	COG0047	phosphoribosylformylglycinamidine synthase activity
E8A47_RS12930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E8A47_RS12940	COG1061	Type III restriction enzyme res subunit
E8A47_RS12945	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E8A47_RS12950	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E8A47_RS12955	COG1187	pseudouridine synthase activity
E8A47_RS12970	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E8A47_RS12975	COG4783	chaperone-mediated protein folding
E8A47_RS12980	COG0425	Belongs to the sulfur carrier protein TusA family
E8A47_RS12990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E8A47_RS12995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E8A47_RS13005	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E8A47_RS13010	COG1720	tRNA m6t6A37 methyltransferase activity
E8A47_RS13025	COG3023	N-Acetylmuramoyl-L-alanine amidase
E8A47_RS13040	COG0563	adenylate kinase activity
E8A47_RS13050	COG0742	ribosomal rna small subunit methyltransferase
E8A47_RS13055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E8A47_RS13065	COG3091	SprT-like family
E8A47_RS13070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E8A47_RS13080	COG0784	Response regulator, receiver
E8A47_RS13080	COG2205	protein histidine kinase activity
E8A47_RS13080	COG2198	Histidine kinase
E8A47_RS13090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E8A47_RS13140	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E8A47_RS13145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E8A47_RS13165	COG3344	reverse transcriptase
E8A47_RS13185	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E8A47_RS13190	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E8A47_RS13270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E8A47_RS13280	COG0398	Pfam SNARE associated Golgi protein
E8A47_RS13300	COG0450	alkyl hydroperoxide reductase
E8A47_RS13305	COG0785	Cytochrome C biogenesis protein
E8A47_RS13335	COG3667	copper resistance
E8A47_RS13390	COG2814	Major facilitator Superfamily
E8A47_RS13425	COG3039	Transposase
E8A47_RS13450	COG4584	PFAM Integrase catalytic
E8A47_RS13455	COG1484	DNA-dependent DNA replication
E8A47_RS13470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E8A47_RS13490	COG2217	Heavy metal translocating P-type atpase
E8A47_RS13500	COG0348	domain, Protein
E8A47_RS13505	COG2010	Cytochrome c
E8A47_RS13520	COG3278	Belongs to the heme-copper respiratory oxidase family
E8A47_RS13555	COG3193	protein, possibly involved in utilization of glycolate and propanediol
E8A47_RS13560	COG0247	lactate metabolic process
E8A47_RS13565	COG0277	FAD linked oxidase domain protein
E8A47_RS13570	COG0277	FAD linked oxidase domain protein
E8A47_RS13575	COG2186	Transcriptional regulator
E8A47_RS13580	COG1802	Transcriptional regulator
E8A47_RS13595	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS13595	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E8A47_RS13600	COG1024	Enoyl-CoA hydratase
E8A47_RS13615	COG0277	FAD linked oxidase domain protein
E8A47_RS13615	COG0247	lactate metabolic process
E8A47_RS13625	COG1620	l-lactate permease
E8A47_RS13635	COG0625	glutathione transferase activity
E8A47_RS13655	COG2351	hydroxyisourate hydrolase activity
E8A47_RS13675	COG1953	Uracil, thiamine, allantoin
E8A47_RS13710	COG0765	amino acid transport
E8A47_RS13720	COG1288	antiporter activity
E8A47_RS13725	COG3257	ureidoglycine aminohydrolase activity
E8A47_RS13730	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E8A47_RS13750	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E8A47_RS13765	COG1192	Involved in chromosome partitioning
E8A47_RS13770	COG0697	spore germination
E8A47_RS13810	COG2211	Major facilitator Superfamily
E8A47_RS13820	COG0673	inositol 2-dehydrogenase activity
E8A47_RS13825	COG1609	Transcriptional regulator
E8A47_RS13830	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS13880	COG0784	Response regulator, receiver
E8A47_RS13880	COG2205	protein histidine kinase activity
E8A47_RS13900	COG0659	secondary active sulfate transmembrane transporter activity
E8A47_RS13905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E8A47_RS13945	COG2205	protein histidine kinase activity
E8A47_RS13950	COG0745	RESPONSE REGULATOR receiver
E8A47_RS13955	COG0745	RESPONSE REGULATOR receiver
E8A47_RS13960	COG2205	protein histidine kinase activity
E8A47_RS13975	COG1309	transcriptional regulator
E8A47_RS13985	COG0604	alcohol dehydrogenase
E8A47_RS13990	COG0583	DNA-binding transcription factor activity
E8A47_RS13995	COG0596	Alpha beta hydrolase
E8A47_RS14000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E8A47_RS14010	COG1944	ATP diphosphatase activity
E8A47_RS14025	COG1115	amino acid carrier protein
E8A47_RS14030	COG0252	asparaginase activity
E8A47_RS14040	COG0700	Nucleoside recognition
E8A47_RS14045	COG2431	L-lysine efflux transmembrane transporter activity
E8A47_RS14055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E8A47_RS14060	COG0006	proline dipeptidase activity
E8A47_RS14065	COG3608	succinylglutamate desuccinylase aspartoacylase
E8A47_RS14070	COG1522	sequence-specific DNA binding
E8A47_RS14075	COG1012	belongs to the aldehyde dehydrogenase family
E8A47_RS14080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E8A47_RS14095	COG1854	S-ribosylhomocysteine lyase activity
E8A47_RS14105	COG1253	flavin adenine dinucleotide binding
E8A47_RS14110	COG0450	alkyl hydroperoxide reductase
E8A47_RS14120	COG1595	DNA-templated transcription, initiation
E8A47_RS14130	COG0789	Transcriptional regulator
E8A47_RS14135	COG2217	Heavy metal translocating P-type atpase
E8A47_RS14140	COG0473	3-isopropylmalate dehydrogenase activity
E8A47_RS14145	COG0659	secondary active sulfate transmembrane transporter activity
E8A47_RS14150	COG0589	response to stress
E8A47_RS14155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E8A47_RS14165	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E8A47_RS14170	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E8A47_RS14175	COG0589	response to stress
E8A47_RS14190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E8A47_RS14205	COG1737	Transcriptional regulator
E8A47_RS14220	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E8A47_RS14225	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E8A47_RS14230	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E8A47_RS14235	COG0585	pseudouridine synthase activity
E8A47_RS14240	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E8A47_RS14245	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E8A47_RS14265	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E8A47_RS14270	COG1560	Kdo2-lipid A biosynthetic process
E8A47_RS14275	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E8A47_RS14280	COG1765	OsmC-like protein
E8A47_RS14290	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E8A47_RS14295	COG3178	'Phosphotransferase
E8A47_RS14300	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E8A47_RS14305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E8A47_RS14310	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E8A47_RS14315	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E8A47_RS14320	COG2967	ApaG domain
E8A47_RS14335	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E8A47_RS14340	COG0617	tRNA 3'-terminal CCA addition
E8A47_RS14355	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E8A47_RS14360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E8A47_RS14365	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E8A47_RS14385	COG2194	sulfuric ester hydrolase activity
E8A47_RS14405	COG0745	RESPONSE REGULATOR receiver
E8A47_RS14410	COG0642	Histidine kinase
E8A47_RS14415	COG1760	l-serine dehydratase
E8A47_RS14420	COG0583	DNA-binding transcription factor activity
E8A47_RS14430	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E8A47_RS14440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E8A47_RS14475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E8A47_RS14495	COG0517	IMP dehydrogenase activity
E8A47_RS14495	COG4175	Glycine betaine
E8A47_RS14510	COG4191	Histidine kinase
E8A47_RS14515	COG2133	pyrroloquinoline quinone binding
E8A47_RS14525	COG0583	DNA-binding transcription factor activity
E8A47_RS14530	COG4771	TonB-dependent receptor
E8A47_RS14535	COG4771	TonB-dependent receptor
E8A47_RS14540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E8A47_RS14545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E8A47_RS14550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E8A47_RS14555	COG1120	ATPase activity
E8A47_RS14560	COG1132	(ABC) transporter
E8A47_RS14630	COG3609	addiction module antidote protein, CC2985 family
E8A47_RS14650	COG0210	DNA helicase
E8A47_RS14670	COG4974	Belongs to the 'phage' integrase family
E8A47_RS14700	COG4774	siderophore transport
E8A47_RS14715	COG0765	amino acid transport
E8A47_RS14735	COG1802	Transcriptional regulator
E8A47_RS14745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E8A47_RS14750	COG3938	Belongs to the proline racemase family
E8A47_RS14770	COG1120	ATPase activity
E8A47_RS14780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E8A47_RS14785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E8A47_RS14805	COG1396	sequence-specific DNA binding
E8A47_RS14810	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E8A47_RS14815	COG3459	Glycosyltransferase 36 associated
E8A47_RS14820	COG0471	metal ion transport
E8A47_RS14825	COG0420	3'-5' exonuclease activity
E8A47_RS14830	COG0419	ATPase involved in DNA repair
E8A47_RS14835	COG2979	Protein of unknown function (DUF533)
E8A47_RS14840	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E8A47_RS14845	COG1012	belongs to the aldehyde dehydrogenase family
E8A47_RS14850	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E8A47_RS14855	COG0583	DNA-binding transcription factor activity
E8A47_RS14870	COG1278	Cold shock
E8A47_RS14875	COG0471	metal ion transport
E8A47_RS14875	COG3273	potassium ion transport
E8A47_RS14890	COG1007	ATP synthesis coupled electron transport
E8A47_RS14895	COG0651	ATP synthesis coupled electron transport
E8A47_RS14900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E8A47_RS14900	COG2111	Na H antiporter
E8A47_RS14905	COG1295	ribonuclease BN
E8A47_RS14910	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E8A47_RS14935	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E8A47_RS14940	COG0513	Belongs to the DEAD box helicase family
E8A47_RS14950	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E8A47_RS14955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E8A47_RS14960	COG0698	ribose 5-phosphate isomerase
E8A47_RS14965	COG2376	Dihydroxyacetone kinase
E8A47_RS14970	COG2390	Transcriptional regulator
E8A47_RS14975	COG1063	alcohol dehydrogenase
E8A47_RS14985	COG1129	ABC transporter
E8A47_RS14990	COG1172	Belongs to the binding-protein-dependent transport system permease family
E8A47_RS14995	COG1879	ABC-type sugar transport system periplasmic component
E8A47_RS15025	COG1609	Transcriptional regulator
E8A47_RS15040	COG1132	(ABC) transporter
E8A47_RS15045	COG0604	alcohol dehydrogenase
E8A47_RS15065	COG0217	transcriptional regulatory protein
E8A47_RS15075	COG0386	Belongs to the glutathione peroxidase family
E8A47_RS15085	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E8A47_RS15100	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS15105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E8A47_RS15120	COG1012	belongs to the aldehyde dehydrogenase family
E8A47_RS15125	COG3724	N-succinylarginine dihydrolase activity
E8A47_RS15150	COG2910	NAD(P)H-binding
E8A47_RS15160	COG1846	Transcriptional regulator
E8A47_RS15175	COG0778	Nitroreductase
E8A47_RS15180	COG3706	GGDEF domain
E8A47_RS15205	COG0154	amidase activity
E8A47_RS15255	COG3263	regulation of cellular component size
E8A47_RS15265	COG1305	Transglutaminase-like
E8A47_RS15280	COG2308	Evidence 4 Homologs of previously reported genes of
E8A47_RS15315	COG0598	Magnesium transport protein CorA
E8A47_RS15325	COG0604	alcohol dehydrogenase
E8A47_RS15325	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS15325	COG3321	synthase
E8A47_RS15330	COG3938	Belongs to the proline racemase family
E8A47_RS15345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E8A47_RS15350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E8A47_RS15360	COG0840	transmembrane signaling receptor activity
E8A47_RS15365	COG0693	protein deglycase activity
E8A47_RS15385	COG3530	Putative quorum-sensing-regulated virulence factor
E8A47_RS15390	COG0583	DNA-binding transcription factor activity
E8A47_RS15400	COG2207	Transcriptional regulator
E8A47_RS15405	COG1064	alcohol dehydrogenase
E8A47_RS15410	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E8A47_RS15415	COG4535	Mg2 and Co2 transporter CorC
E8A47_RS15420	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E8A47_RS15425	COG1702	phosphate starvation-inducible protein PhoH
E8A47_RS15430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E8A47_RS15450	COG0640	Transcriptional regulator
E8A47_RS15455	COG0793	Belongs to the peptidase S41A family
E8A47_RS15460	COG1362	aminopeptidase activity
E8A47_RS15470	COG0012	GTP binding
E8A47_RS15475	COG0193	aminoacyl-tRNA hydrolase activity
E8A47_RS15480	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E8A47_RS15495	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E8A47_RS15500	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E8A47_RS15510	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E8A47_RS15515	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E8A47_RS15520	COG2890	protein-(glutamine-N5) methyltransferase activity
E8A47_RS15530	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E8A47_RS15550	COG4106	trans-aconitate 2-methyltransferase activity
E8A47_RS15595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E8A47_RS15600	COG0584	glycerophosphoryl diester phosphodiesterase
E8A47_RS15630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E8A47_RS15640	COG1473	amidohydrolase
E8A47_RS15645	COG0583	DNA-binding transcription factor activity
E8A47_RS15650	COG0667	Aldo Keto reductase
E8A47_RS15665	COG4115	mRNA cleavage
E8A47_RS15675	COG2249	NAD(P)H dehydrogenase (quinone) activity
E8A47_RS15695	COG0159	tryptophan synthase activity
E8A47_RS15705	COG0583	DNA-binding transcription factor activity
E8A47_RS15740	COG0640	Transcriptional regulator
E8A47_RS15760	COG1012	belongs to the aldehyde dehydrogenase family
E8A47_RS15765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E8A47_RS15770	COG0456	acetyltransferase
E8A47_RS15775	COG1177	transmembrane transport
E8A47_RS15780	COG1176	ABC-type spermidine putrescine transport system, permease component I
E8A47_RS15790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E8A47_RS15800	COG3842	ATPase activity
E8A47_RS15805	COG0583	DNA-binding transcription factor activity
E8A47_RS15810	COG0300	oxidoreductase activity
E8A47_RS15815	COG2207	Transcriptional regulator
E8A47_RS15830	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS15840	COG1733	regulation of RNA biosynthetic process
E8A47_RS15845	COG0456	acetyltransferase
E8A47_RS15850	COG0840	transmembrane signaling receptor activity
E8A47_RS15855	COG0488	(ABC) transporter
E8A47_RS15865	COG2824	Alkylphosphonate utilization operon protein PhnA
E8A47_RS15870	COG2271	Major facilitator Superfamily
E8A47_RS15890	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
E8A47_RS15900	COG0583	DNA-binding transcription factor activity
E8A47_RS15920	COG0833	amino acid
E8A47_RS15925	COG2040	homocysteine
E8A47_RS15960	COG2814	Major facilitator Superfamily
E8A47_RS15970	COG0583	DNA-binding transcription factor activity
E8A47_RS15975	COG0697	spore germination
E8A47_RS16080	COG4974	Belongs to the 'phage' integrase family
E8A47_RS16085	COG0517	IMP dehydrogenase activity
E8A47_RS16105	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E8A47_RS16110	COG1074	ATP-dependent DNA helicase activity
E8A47_RS16115	COG0583	DNA-binding transcription factor activity
E8A47_RS16125	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E8A47_RS16130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E8A47_RS16145	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E8A47_RS16155	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E8A47_RS16160	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E8A47_RS16165	COG3657	addiction module killer protein
E8A47_RS16170	COG0129	dihydroxy-acid dehydratase activity
E8A47_RS16185	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E8A47_RS16205	COG4160	amino acid transport
E8A47_RS16220	COG2988	succinylglutamate desuccinylase activity
E8A47_RS16230	COG0655	NAD(P)H dehydrogenase (quinone) activity
E8A47_RS16240	COG0473	3-isopropylmalate dehydrogenase activity
E8A47_RS16245	COG0583	DNA-binding transcription factor activity
E8A47_RS16250	COG3040	lipid binding
E8A47_RS16285	COG1115	amino acid carrier protein
E8A47_RS16300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E8A47_RS16300	COG3153	acetyltransferase
E8A47_RS16305	COG0697	spore germination
E8A47_RS16310	COG1902	pentaerythritol trinitrate reductase activity
E8A47_RS16310	COG0446	pyridine nucleotide-disulphide oxidoreductase
E8A47_RS16320	COG2766	serine protein kinase
E8A47_RS16325	COG2718	Belongs to the UPF0229 family
E8A47_RS16330	COG2719	SpoVR family
E8A47_RS16350	COG0583	DNA-binding transcription factor activity
E8A47_RS16360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E8A47_RS16380	COG0557	exoribonuclease II activity
E8A47_RS16385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E8A47_RS16390	COG0360	Binds together with S18 to 16S ribosomal RNA
E8A47_RS16395	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E8A47_RS16405	COG0359	binds to the 23S rRNA
E8A47_RS16410	COG0305	Participates in initiation and elongation during chromosome replication
E8A47_RS16430	COG3046	protein related to deoxyribodipyrimidine photolyase
E8A47_RS16440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E8A47_RS16440	COG2111	Na H antiporter
E8A47_RS16445	COG2111	Na H antiporter
E8A47_RS16450	COG1006	Multisubunit Na H antiporter MnhC subunit
E8A47_RS16455	COG0651	ATP synthesis coupled electron transport
E8A47_RS16460	COG1863	multisubunit Na H antiporter MnhE subunit
E8A47_RS16465	COG2212	antiporter activity
E8A47_RS16470	COG1320	monovalent cation:proton antiporter activity
E8A47_RS16480	COG0415	Belongs to the DNA photolyase family
E8A47_RS16485	COG2951	lytic endotransglycosylase activity
E8A47_RS16490	COG4067	protein conserved in archaea
E8A47_RS16490	COG0189	ligase activity
E8A47_RS16500	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
E8A47_RS16505	COG0151	Belongs to the GarS family
E8A47_RS16515	COG3954	Phosphoribulokinase
E8A47_RS16520	COG0537	adenosine 5'-monophosphoramidase activity
E8A47_RS16525	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
E8A47_RS16535	COG0488	(ABC) transporter
E8A47_RS16545	COG1366	Belongs to the anti-sigma-factor antagonist family
E8A47_RS16565	COG1538	Outer membrane efflux protein
E8A47_RS16570	COG2274	protein secretion by the type I secretion system
E8A47_RS16575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8A47_RS16610	COG4181	ATPase activity
E8A47_RS16615	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E8A47_RS16635	COG2840	Smr protein MutS2
E8A47_RS16645	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E8A47_RS16660	COG3243	poly(R)-hydroxyalkanoic acid synthase
E8A47_RS16680	COG3842	ATPase activity
E8A47_RS16685	COG1176	ABC-type spermidine putrescine transport system, permease component I
E8A47_RS16690	COG1177	transmembrane transport
E8A47_RS16705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E8A47_RS16715	COG2081	HI0933 family
E8A47_RS16730	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS16735	COG1063	alcohol dehydrogenase
E8A47_RS16740	COG2814	Major facilitator Superfamily
E8A47_RS16755	COG4575	ribosome binding
E8A47_RS16765	COG3264	Mechanosensitive ion channel
E8A47_RS16765	COG1196	nuclear chromosome segregation
E8A47_RS16770	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E8A47_RS16790	COG4991	sh3 domain protein
E8A47_RS16795	COG0500	methyltransferase
E8A47_RS16805	COG0697	spore germination
E8A47_RS16815	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E8A47_RS16820	COG4208	sulfate ABC transporter
E8A47_RS16840	COG1252	NADH dehydrogenase
E8A47_RS16845	COG0546	phosphoglycolate phosphatase activity
E8A47_RS16850	COG0803	Belongs to the bacterial solute-binding protein 9 family
E8A47_RS16855	COG0512	Glutamine amidotransferase of anthranilate synthase
E8A47_RS16860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E8A47_RS16865	COG0134	indole-3-glycerol-phosphate synthase activity
E8A47_RS16870	COG0277	FAD linked oxidase domain protein
E8A47_RS16870	COG0247	lactate metabolic process
E8A47_RS16885	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E8A47_RS16895	COG0628	permease
E8A47_RS16900	COG3118	belongs to the thioredoxin family
E8A47_RS16910	COG0175	sulfate reduction
E8A47_RS16920	COG1802	Transcriptional regulator
E8A47_RS16925	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E8A47_RS16930	COG0372	Belongs to the citrate synthase family
E8A47_RS16955	COG0284	orotidine-5'-phosphate decarboxylase activity
E8A47_RS16960	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E8A47_RS16970	COG0776	regulation of translation
E8A47_RS16975	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E8A47_RS16985	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E8A47_RS17010	COG0322	excinuclease ABC activity
E8A47_RS17025	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E8A47_RS17030	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E8A47_RS17035	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E8A47_RS17040	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E8A47_RS17045	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E8A47_RS17055	COG3100	YcgL domain-containing protein
E8A47_RS17065	COG2983	Belongs to the UPF0260 family
E8A47_RS17080	COG0121	glutamine amidotransferase
E8A47_RS17085	COG0318	PFAM AMP-dependent synthetase and ligase
E8A47_RS17090	COG1643	Atp-dependent helicase
E8A47_RS17100	COG2853	Lipoprotein
E8A47_RS17115	COG2814	Major facilitator Superfamily
E8A47_RS17130	COG0573	inorganic phosphate transmembrane transporter activity
E8A47_RS17140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E8A47_RS17145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E8A47_RS17170	COG0798	PFAM Bile acid sodium symporter
E8A47_RS17175	COG0431	NADPH-dependent FMN reductase
E8A47_RS17185	COG0840	transmembrane signaling receptor activity
E8A47_RS17190	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E8A47_RS17195	COG0183	Belongs to the thiolase family
E8A47_RS17205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E8A47_RS17215	COG1960	acyl-CoA dehydrogenase activity
E8A47_RS17235	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E8A47_RS17240	COG2329	Antibiotic biosynthesis monooxygenase
E8A47_RS17265	COG3101	peptidyl-lysine hydroxylation
E8A47_RS17275	COG0084	hydrolase, TatD family'
E8A47_RS17300	COG0183	Belongs to the thiolase family
E8A47_RS17305	COG0318	PFAM AMP-dependent synthetase and ligase
E8A47_RS17315	COG0488	(ABC) transporter
E8A47_RS17320	COG0589	response to stress
E8A47_RS17330	COG1846	Transcriptional regulator
E8A47_RS17345	COG0183	Belongs to the thiolase family
E8A47_RS17375	COG2824	Alkylphosphonate utilization operon protein PhnA
E8A47_RS17390	COG0719	Fe-S assembly protein
E8A47_RS17395	COG0396	ATPase activity
E8A47_RS17400	COG0719	Fe-S assembly protein
E8A47_RS17415	COG2949	membrane
E8A47_RS17425	COG0189	ligase activity
E8A47_RS17440	COG3098	single-species biofilm formation
E8A47_RS17445	COG3047	cAMP biosynthetic process
E8A47_RS17475	COG2161	toxin-antitoxin pair type II binding
E8A47_RS17485	COG0506	proline dehydrogenase activity
E8A47_RS17485	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E8A47_RS17485	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E8A47_RS17490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E8A47_RS17510	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E8A47_RS17510	COG0617	tRNA 3'-terminal CCA addition
E8A47_RS17510	COG0517	IMP dehydrogenase activity
E8A47_RS17515	COG0401	homolog of Blt101
E8A47_RS17520	COG0697	spore germination
E8A47_RS17525	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E8A47_RS17560	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E8A47_RS17560	COG2010	Cytochrome c
E8A47_RS17565	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E8A47_RS17575	COG2217	Heavy metal translocating P-type atpase
E8A47_RS17590	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS17600	COG0166	Belongs to the GPI family
E8A47_RS17605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E8A47_RS17605	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E8A47_RS17605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E8A47_RS17610	COG1105	Belongs to the carbohydrate kinase PfkB family
E8A47_RS17615	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E8A47_RS17615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E8A47_RS17625	COG1803	Methylglyoxal synthase
E8A47_RS17630	COG0469	pyruvate kinase activity
E8A47_RS17640	COG1609	Transcriptional regulator
E8A47_RS17645	COG3842	ATPase activity
E8A47_RS17650	COG0366	Alpha amylase catalytic
E8A47_RS17665	COG1653	transport
E8A47_RS17675	COG2909	trisaccharide binding
E8A47_RS17680	COG0366	Alpha amylase catalytic
E8A47_RS17695	COG1595	DNA-templated transcription, initiation
E8A47_RS17705	COG0569	domain protein
E8A47_RS17710	COG0745	RESPONSE REGULATOR receiver
E8A47_RS17715	COG2205	protein histidine kinase activity
E8A47_RS17720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E8A47_RS17725	COG3833	ABC-type maltose transport systems, permease component
E8A47_RS17735	COG2182	Extracellular solute-binding protein
E8A47_RS17755	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E8A47_RS17765	COG0800	Aldolase
E8A47_RS17770	COG3734	2-keto-3-deoxy-galactonokinase
E8A47_RS17775	COG4948	Mandelate Racemase Muconate Lactonizing
E8A47_RS17785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E8A47_RS17795	COG0837	glucose binding
E8A47_RS17805	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E8A47_RS17810	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E8A47_RS17815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E8A47_RS17825	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E8A47_RS17830	COG0406	alpha-ribazole phosphatase activity
E8A47_RS17845	COG4206	TonB-dependent receptor
E8A47_RS17850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E8A47_RS17855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E8A47_RS17860	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E8A47_RS17870	COG0113	porphobilinogen synthase activity
E8A47_RS17895	COG1120	ATPase activity
E8A47_RS17900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E8A47_RS17920	COG1797	cobyrinic acid a,c-diamide synthase activity
E8A47_RS17955	COG2099	Precorrin-6x reductase
E8A47_RS17970	COG2875	Belongs to the precorrin methyltransferase family
E8A47_RS17995	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E8A47_RS18000	COG0513	Belongs to the DEAD box helicase family
E8A47_RS18025	COG0789	Transcriptional regulator
E8A47_RS18070	COG0789	Transcriptional regulator
E8A47_RS18145	COG0537	adenosine 5'-monophosphoramidase activity
E8A47_RS18155	COG0519	Catalyzes the synthesis of GMP from XMP
E8A47_RS18200	COG1846	Transcriptional regulator
E8A47_RS18200	COG0456	acetyltransferase
E8A47_RS18215	COG2226	methyltransferase
E8A47_RS18225	COG1030	water channel activity
E8A47_RS18235	COG2329	Antibiotic biosynthesis monooxygenase
E8A47_RS18260	COG2066	Belongs to the glutaminase family
E8A47_RS18265	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E8A47_RS18270	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E8A47_RS18275	COG3842	ATPase activity
E8A47_RS18280	COG1177	transmembrane transport
E8A47_RS18285	COG4149	molybdate abc transporter
E8A47_RS18295	COG1609	Transcriptional regulator
E8A47_RS18300	COG1492	cobalamin metabolic process
E8A47_RS18325	COG0542	response to heat
E8A47_RS18330	COG3284	Transcriptional regulator
E8A47_RS18335	COG2072	flavoprotein involved in K transport
E8A47_RS18340	COG1063	alcohol dehydrogenase
E8A47_RS18350	COG0006	proline dipeptidase activity
E8A47_RS18355	COG0583	DNA-binding transcription factor activity
E8A47_RS18360	COG4608	Belongs to the ABC transporter superfamily
E8A47_RS18370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E8A47_RS18375	COG0601	transmembrane transport
E8A47_RS18395	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E8A47_RS18405	COG1280	lysine exporter protein (LysE YggA)
E8A47_RS18410	COG0586	Pfam SNARE associated Golgi protein
E8A47_RS18425	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E8A47_RS18430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E8A47_RS18440	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E8A47_RS18445	COG0768	penicillin binding
E8A47_RS18450	COG0772	Belongs to the SEDS family
E8A47_RS18455	COG2951	lytic endotransglycosylase activity
E8A47_RS18465	COG1686	Belongs to the peptidase S11 family
E8A47_RS18470	COG2921	Belongs to the UPF0250 family
E8A47_RS18475	COG0321	lipoyl(octanoyl) transferase activity
E8A47_RS18480	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E8A47_RS18485	COG0583	DNA-binding transcription factor activity
E8A47_RS18520	COG1388	LysM domain
E8A47_RS18520	COG1376	ErfK ybiS ycfS ynhG family protein
E8A47_RS18525	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E8A47_RS18535	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E8A47_RS18540	COG1805	sodium ion transport
E8A47_RS18550	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E8A47_RS18555	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E8A47_RS18570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E8A47_RS18600	COG0495	leucyl-tRNA aminoacylation
E8A47_RS18670	COG3093	addiction module antidote protein HigA
E8A47_RS18690	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
E8A47_RS18695	COG0456	acetyltransferase
E8A47_RS18705	COG0456	acetyltransferase
E8A47_RS18725	COG2818	Glycosylase
E8A47_RS18795	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E8A47_RS18805	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E8A47_RS18810	COG0066	3-isopropylmalate dehydratase activity
E8A47_RS18815	COG0473	3-isopropylmalate dehydrogenase activity
E8A47_RS18830	COG0101	tRNA pseudouridine synthase activity
E8A47_RS18835	COG0135	phosphoribosylanthranilate isomerase activity
E8A47_RS18845	COG0159	tryptophan synthase activity
E8A47_RS18850	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E8A47_RS18855	COG0285	dihydrofolate synthase activity
E8A47_RS18885	COG3038	cytochrome b561
E8A47_RS18890	COG2353	YceI-like domain
E8A47_RS18895	COG0534	Mate efflux family protein
E8A47_RS18910	COG2154	pterin-4-alpha-carbinolamine dehydratase
E8A47_RS18920	COG1648	precorrin-2 dehydrogenase activity
E8A47_RS18920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E8A47_RS18930	COG0489	protein tyrosine kinase activity
E8A47_RS18935	COG0717	Belongs to the dCTP deaminase family
E8A47_RS18940	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E8A47_RS18945	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E8A47_RS18950	COG0628	permease
E8A47_RS18985	COG1956	GAF domain-containing protein
E8A47_RS18990	COG1464	Belongs to the NlpA lipoprotein family
E8A47_RS18995	COG2011	ABC-type metal ion transport system permease component
E8A47_RS19000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E8A47_RS19005	COG0307	riboflavin synthase, alpha
E8A47_RS19010	COG2252	PERMEase
E8A47_RS19015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E8A47_RS19020	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E8A47_RS19025	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E8A47_RS19030	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E8A47_RS19040	COG1763	Mo-molybdopterin cofactor biosynthetic process
E8A47_RS19045	COG0315	cyclic pyranopterin monophosphate synthase activity
E8A47_RS19050	COG0314	molybdopterin synthase activity
E8A47_RS19070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E8A47_RS19075	COG1309	transcriptional regulator
E8A47_RS19080	COG1376	ErfK ybiS ycfS ynhG family protein
E8A47_RS19090	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E8A47_RS19095	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E8A47_RS19105	COG0405	Gamma-glutamyltransferase
E8A47_RS19110	COG0584	glycerophosphoryl diester phosphodiesterase
E8A47_RS19115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E8A47_RS19145	COG0602	queuosine metabolic process
E8A47_RS19150	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E8A47_RS19165	COG0252	asparaginase activity
E8A47_RS19170	COG2807	transmembrane transport
E8A47_RS19180	COG0513	Belongs to the DEAD box helicase family
E8A47_RS19190	COG3009	Protein conserved in bacteria
E8A47_RS19195	COG3008	intermembrane lipid transfer
E8A47_RS19195	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E8A47_RS19200	COG2995	paraquat-inducible protein a
E8A47_RS19210	COG1271	oxidase subunit
E8A47_RS19215	COG1294	oxidase, subunit
E8A47_RS19220	COG4988	ABC transporter
E8A47_RS19225	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E8A47_RS19230	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E8A47_RS19265	COG0402	S-adenosylhomocysteine deaminase activity
E8A47_RS19275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E8A47_RS19285	COG1309	transcriptional regulator
E8A47_RS19290	COG1643	Atp-dependent helicase
E8A47_RS19315	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E8A47_RS19340	COG1612	heme a metabolic process
E8A47_RS19345	COG0109	protoheme IX farnesyltransferase activity
E8A47_RS19360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E8A47_RS19365	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E8A47_RS19370	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E8A47_RS19375	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E8A47_RS19380	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E8A47_RS19385	COG0072	phenylalanine-tRNA ligase activity
E8A47_RS19390	COG0776	regulation of translation
E8A47_RS19400	COG0716	FMN binding
E8A47_RS19410	COG0544	peptidyl-prolyl cis-trans isomerase activity
E8A47_RS19415	COG0740	serine-type endopeptidase activity
E8A47_RS19420	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E8A47_RS19425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E8A47_RS19435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E8A47_RS19440	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E8A47_RS19445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E8A47_RS19450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E8A47_RS19455	COG0215	cysteine-tRNA ligase activity
E8A47_RS19460	COG1732	Glycine betaine
E8A47_RS19465	COG1174	glycine betaine transport
E8A47_RS19470	COG1125	glycine betaine transport
E8A47_RS19475	COG1174	glycine betaine transport
E8A47_RS19485	COG0022	dehydrogenase e1 component
E8A47_RS19495	COG0515	serine threonine protein kinase
E8A47_RS19515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E8A47_RS19520	COG1414	Transcriptional regulator
E8A47_RS19525	COG0183	Belongs to the thiolase family
E8A47_RS19530	COG1250	3-hydroxyacyl-CoA dehydrogenase
E8A47_RS19535	COG1960	acyl-CoA dehydrogenase activity
E8A47_RS19540	COG0318	PFAM AMP-dependent synthetase and ligase
E8A47_RS19570	COG1024	Enoyl-CoA hydratase
E8A47_RS19575	COG1960	acyl-CoA dehydrogenase activity
E8A47_RS19580	COG1960	acyl-CoA dehydrogenase activity
E8A47_RS19585	COG1024	Enoyl-CoA hydratase
E8A47_RS19600	COG0659	secondary active sulfate transmembrane transporter activity
E8A47_RS19610	COG2962	Rard protein
E8A47_RS19625	COG4172	Belongs to the ABC transporter superfamily
E8A47_RS19630	COG4239	(ABC) transporter, permease
E8A47_RS19635	COG4174	ABC transporter (Permease)
E8A47_RS19640	COG4166	transmembrane transport
E8A47_RS19645	COG0741	lytic transglycosylase activity
E8A47_RS19645	COG1388	LysM domain
E8A47_RS19650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E8A47_RS19660	COG0328	RNA-DNA hybrid ribonuclease activity
E8A47_RS19665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E8A47_RS19670	COG2816	NAD+ diphosphatase activity
E8A47_RS19680	COG0616	signal peptide processing
E8A47_RS19685	COG0640	Transcriptional regulator
E8A47_RS19695	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E8A47_RS19700	COG0596	Alpha beta hydrolase
E8A47_RS19710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E8A47_RS19715	COG3263	regulation of cellular component size
E8A47_RS19760	COG0446	pyridine nucleotide-disulphide oxidoreductase
E8A47_RS19795	COG1522	sequence-specific DNA binding
E8A47_RS19800	COG1280	lysine exporter protein (LysE YggA)
E8A47_RS19820	COG3453	Protein conserved in bacteria
E8A47_RS19820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E8A47_RS19825	COG0450	alkyl hydroperoxide reductase
E8A47_RS19835	COG1609	Transcriptional regulator
E8A47_RS19840	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E8A47_RS19845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E8A47_RS19850	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS19855	COG1172	Belongs to the binding-protein-dependent transport system permease family
E8A47_RS19860	COG1129	ABC transporter
E8A47_RS19865	COG1879	ABC-type sugar transport system periplasmic component
E8A47_RS19890	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E8A47_RS19940	COG2188	Transcriptional regulator
E8A47_RS19985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E8A47_RS20015	COG2923	Belongs to the DsrF TusC family
E8A47_RS20035	COG0123	including yeast histone deacetylase and acetoin utilization protein
E8A47_RS20040	COG0045	succinate-CoA ligase (ADP-forming) activity
E8A47_RS20040	COG1042	CoA-binding domain protein
E8A47_RS20040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E8A47_RS20045	COG0259	pyridoxamine-phosphate oxidase activity
E8A47_RS20070	COG2840	Smr protein MutS2
E8A47_RS20080	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E8A47_RS20085	COG0534	Mate efflux family protein
E8A47_RS20095	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E8A47_RS20095	COG0316	Belongs to the HesB IscA family
E8A47_RS20110	COG2166	iron-sulfur cluster assembly
E8A47_RS20115	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E8A47_RS20120	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E8A47_RS20125	COG0735	belongs to the Fur family
E8A47_RS20140	COG0189	ligase activity
E8A47_RS20140	COG4067	protein conserved in archaea
E8A47_RS20145	COG1917	Cupin 2, conserved barrel domain protein
E8A47_RS20150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E8A47_RS20155	COG0456	acetyltransferase
E8A47_RS20165	COG0288	reversible hydration of carbon dioxide
E8A47_RS20175	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E8A47_RS20180	COG2911	Protein conserved in bacteria
E8A47_RS20185	COG0729	surface antigen
E8A47_RS20200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E8A47_RS20205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E8A47_RS20215	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS20225	COG2885	chlorophyll binding
E8A47_RS20230	COG0823	Involved in the tonB-independent uptake of proteins
E8A47_RS20250	COG0824	Thioesterase
E8A47_RS20255	COG2255	four-way junction helicase activity
E8A47_RS20260	COG0632	four-way junction helicase activity
E8A47_RS20265	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E8A47_RS20270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E8A47_RS20280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E8A47_RS20285	COG1254	Belongs to the acylphosphatase family
E8A47_RS20290	COG1295	ribonuclease BN
E8A47_RS20295	COG1051	belongs to the nudix hydrolase family
E8A47_RS20295	COG1056	cytidyltransferase-related domain
E8A47_RS20300	COG0583	DNA-binding transcription factor activity
E8A47_RS20305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E8A47_RS20315	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E8A47_RS20320	COG0556	nucleotide-excision repair
E8A47_RS20335	COG0354	folic acid binding
E8A47_RS20340	COG0084	hydrolase, TatD family'
E8A47_RS20345	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E8A47_RS20360	COG0004	ammonium transporteR
E8A47_RS20385	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E8A47_RS20390	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E8A47_RS20395	COG0418	dihydroorotase activity
E8A47_RS20405	COG4191	Histidine kinase
E8A47_RS20410	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E8A47_RS20415	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS20440	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E8A47_RS20445	COG0583	DNA-binding transcription factor activity
E8A47_RS20460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E8A47_RS20465	COG1115	amino acid carrier protein
E8A47_RS20470	COG0509	glycine decarboxylation via glycine cleavage system
E8A47_RS20480	COG0583	DNA-binding transcription factor activity
E8A47_RS20485	COG1611	Belongs to the LOG family
E8A47_RS20505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E8A47_RS20515	COG0303	'Molybdopterin
E8A47_RS20520	COG0521	Mo-molybdopterin cofactor biosynthetic process
E8A47_RS20525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E8A47_RS20530	COG2181	nitrate reductase activity
E8A47_RS20535	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E8A47_RS20540	COG1140	nitrate reductase beta subunit
E8A47_RS20545	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E8A47_RS20555	COG0826	peptidase U32
E8A47_RS20560	COG0826	peptidase U32
E8A47_RS20565	COG0243	molybdopterin cofactor binding
E8A47_RS20570	COG0437	4 iron, 4 sulfur cluster binding
E8A47_RS20575	COG3302	dmso reductase anchor subunit
E8A47_RS20580	COG3381	protein complex oligomerization
E8A47_RS20585	COG2221	Nitrite and sulphite reductase 4Fe-4S
E8A47_RS20585	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E8A47_RS20600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E8A47_RS20605	COG1959	2 iron, 2 sulfur cluster binding
E8A47_RS20620	COG1017	nitric oxide dioxygenase activity
E8A47_RS20620	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E8A47_RS20625	COG3154	lipid carrier protein
E8A47_RS20630	COG1845	cytochrome c oxidase, subunit III
E8A47_RS20650	COG0714	Associated with various cellular activities
E8A47_RS20670	COG3189	MarR family transcriptional regulator
E8A47_RS20680	COG3901	Regulator of nitric oxide reductase transcription
E8A47_RS20680	COG0348	domain, Protein
E8A47_RS20700	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E8A47_RS20725	COG3850	Histidine kinase
E8A47_RS20730	COG2197	response regulator
E8A47_RS20745	COG2223	nitrite transmembrane transporter activity
E8A47_RS20775	COG1733	regulation of RNA biosynthetic process
E8A47_RS20785	COG1764	response to oxidative stress
E8A47_RS20805	COG2186	Transcriptional regulator
E8A47_RS20815	COG1741	Belongs to the pirin family
E8A47_RS20835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E8A47_RS20875	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E8A47_RS20880	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E8A47_RS20885	COG0237	dephospho-CoA kinase activity
E8A47_RS20925	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E8A47_RS20930	COG1605	Chorismate mutase
E8A47_RS20930	COG0077	Prephenate dehydratase
E8A47_RS20935	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E8A47_RS20945	COG0824	Thioesterase
E8A47_RS20965	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E8A47_RS20965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E8A47_RS20970	COG4657	Part of a membrane complex involved in electron transport
E8A47_RS20975	COG2878	Part of a membrane complex involved in electron transport
E8A47_RS20985	COG4658	electron transport chain
E8A47_RS20990	COG4659	FMN binding
E8A47_RS20995	COG4660	Part of a membrane complex involved in electron transport
E8A47_RS21000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E8A47_RS21015	COG2176	DNA-directed DNA polymerase activity
E8A47_RS21015	COG5002	protein histidine kinase activity
E8A47_RS21025	COG5002	protein histidine kinase activity
E8A47_RS21030	COG2199	diguanylate cyclase activity
E8A47_RS21030	COG2200	EAL domain
E8A47_RS21030	COG2202	Pas domain
E8A47_RS21045	COG0137	argininosuccinate synthase activity
E8A47_RS21050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E8A47_RS21055	COG0205	6-phosphofructokinase activity
E8A47_RS21065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E8A47_RS21070	COG1012	belongs to the aldehyde dehydrogenase family
E8A47_RS21075	COG0604	alcohol dehydrogenase
E8A47_RS21080	COG0583	DNA-binding transcription factor activity
E8A47_RS21085	COG2207	Transcriptional regulator
E8A47_RS21090	COG4221	oxidoreductase activity
E8A47_RS21100	COG0511	ligase activity, forming carbon-carbon bonds
E8A47_RS21110	COG2264	protein methyltransferase activity
E8A47_RS21120	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E8A47_RS21135	COG0302	gtp cyclohydrolase
E8A47_RS21145	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E8A47_RS21185	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS21195	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E8A47_RS21200	COG0459	protein refolding
E8A47_RS21210	COG2056	Na+-H+ antiporter family
E8A47_RS21225	COG4651	solute:proton antiporter activity
E8A47_RS21225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E8A47_RS21235	COG1321	iron dependent repressor
E8A47_RS21240	COG4451	ribulose bisphosphate carboxylase, small
E8A47_RS21240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E8A47_RS21245	COG1216	Glycosyl transferase, family 2
E8A47_RS21250	COG2755	lipolytic protein G-D-S-L family
E8A47_RS21250	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E8A47_RS21270	COG0463	Glycosyl transferase, family 2
E8A47_RS21270	COG1216	Glycosyl transferase, family 2
E8A47_RS21280	COG1216	Glycosyl transferase, family 2
E8A47_RS21285	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E8A47_RS21320	COG1132	(ABC) transporter
E8A47_RS21345	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E8A47_RS21350	COG3307	-O-antigen
E8A47_RS21370	COG0071	Belongs to the small heat shock protein (HSP20) family
E8A47_RS21375	COG3243	poly(R)-hydroxyalkanoic acid synthase
E8A47_RS21390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E8A47_RS21390	COG0045	succinate-CoA ligase (ADP-forming) activity
E8A47_RS21390	COG1042	CoA-binding domain protein
E8A47_RS21405	COG1063	alcohol dehydrogenase
E8A47_RS21440	COG0842	Transport permease protein
E8A47_RS21445	COG0842	Transport permease protein
E8A47_RS21445	COG1129	ABC transporter
E8A47_RS21450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8A47_RS21485	COG1960	acyl-CoA dehydrogenase activity
E8A47_RS21490	COG3842	ATPase activity
E8A47_RS21495	COG3842	ATPase activity
E8A47_RS21505	COG0395	ABC-type sugar transport system, permease component
E8A47_RS21520	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E8A47_RS21530	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E8A47_RS21540	COG1349	DNA-binding transcription factor activity
E8A47_RS21545	COG0471	metal ion transport
E8A47_RS21545	COG3273	potassium ion transport
E8A47_RS21555	COG0584	glycerophosphoryl diester phosphodiesterase
E8A47_RS21560	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E8A47_RS21565	COG0154	amidase activity
E8A47_RS21575	COG0442	prolyl-tRNA aminoacylation
E8A47_RS21605	COG5001	Diguanylate cyclase
E8A47_RS21605	COG4251	negative regulation of phosphorylation
E8A47_RS21605	COG3706	GGDEF domain
E8A47_RS21605	COG2203	Gaf domain
E8A47_RS21615	COG1047	Peptidyl-prolyl cis-trans
E8A47_RS21620	COG2807	transmembrane transport
E8A47_RS21625	COG0653	protein targeting
E8A47_RS21630	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E8A47_RS21635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E8A47_RS21640	COG1285	pathogenesis
E8A47_RS21645	COG0583	DNA-binding transcription factor activity
E8A47_RS21650	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E8A47_RS21660	COG1280	lysine exporter protein (LysE YggA)
E8A47_RS21670	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E8A47_RS21675	COG0501	Belongs to the peptidase M48B family
E8A47_RS21680	COG1704	LemA family
E8A47_RS21685	COG3483	tryptophan 2,3-dioxygenase activity
E8A47_RS21700	COG3706	GGDEF domain
E8A47_RS21720	COG0024	Methionine aminopeptidase
E8A47_RS21740	COG3706	GGDEF domain
E8A47_RS21775	COG1280	lysine exporter protein (LysE YggA)
E8A47_RS21785	COG1695	Transcriptional regulator
E8A47_RS21810	COG0671	phosphoesterase, PA-phosphatase related
E8A47_RS21840	COG0517	IMP dehydrogenase activity
E8A47_RS21845	COG4974	Belongs to the 'phage' integrase family
E8A47_RS21865	COG0625	glutathione transferase activity
E8A47_RS21875	COG1024	Enoyl-CoA hydratase
E8A47_RS21875	COG1250	3-hydroxyacyl-CoA dehydrogenase
E8A47_RS21880	COG1960	acyl-CoA dehydrogenase activity
E8A47_RS21915	COG1960	acyl-CoA dehydrogenase activity
E8A47_RS21920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E8A47_RS21925	COG1024	Enoyl-CoA hydratase
E8A47_RS21940	COG0318	PFAM AMP-dependent synthetase and ligase
E8A47_RS21945	COG2226	methyltransferase
E8A47_RS21955	COG3501	Rhs element vgr protein
E8A47_RS21990	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
E8A47_RS22020	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E8A47_RS22025	COG3956	TIGRFAM MazG family protein
E8A47_RS22030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E8A47_RS22035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E8A47_RS22050	COG0736	holo-[acyl-carrier-protein] synthase activity
E8A47_RS22055	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E8A47_RS22060	COG1381	Involved in DNA repair and RecF pathway recombination
E8A47_RS22070	COG0571	ribonuclease III activity
E8A47_RS22080	COG0481	GTPase activity
E8A47_RS22085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E8A47_RS22115	COG1199	ATP-dependent helicase activity
E8A47_RS22130	COG0708	Exodeoxyribonuclease III
E8A47_RS22145	COG0848	biopolymer transport protein
E8A47_RS22150	COG0811	peptide transport
E8A47_RS22155	COG0811	peptide transport
E8A47_RS22170	COG0697	spore germination
E8A47_RS22180	COG0494	nUDIX hydrolase
E8A47_RS22190	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E8A47_RS22195	COG1780	Probably involved in ribonucleotide reductase function
E8A47_RS22205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E8A47_RS22225	COG4251	negative regulation of phosphorylation
E8A47_RS22225	COG3706	GGDEF domain
E8A47_RS22225	COG5001	Diguanylate cyclase
E8A47_RS22225	COG2203	Gaf domain
E8A47_RS22240	COG0210	DNA helicase
E8A47_RS22250	COG0084	hydrolase, TatD family'
E8A47_RS22265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E8A47_RS22270	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E8A47_RS22280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E8A47_RS22285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E8A47_RS22300	COG0416	fatty acid biosynthetic process
E8A47_RS22305	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E8A47_RS22310	COG1399	metal-binding, possibly nucleic acid-binding protein
E8A47_RS22315	COG0424	maF-like protein
E8A47_RS22325	COG0546	phosphoglycolate phosphatase activity
E8A47_RS22335	COG1530	ribonuclease E activity
E8A47_RS22340	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E8A47_RS22345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E8A47_RS22350	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E8A47_RS22355	COG2835	tetraacyldisaccharide 4'-kinase activity
E8A47_RS22360	COG1663	tetraacyldisaccharide 4'-kinase activity
E8A47_RS22365	COG1132	(ABC) transporter
E8A47_RS22370	COG2333	competence protein COMEC
E8A47_RS22370	COG0658	competence protein
E8A47_RS22380	COG1136	(ABC) transporter
E8A47_RS22385	COG4591	ABC-type transport system involved in lipoprotein release permease component
E8A47_RS22390	COG2957	Belongs to the agmatine deiminase family
E8A47_RS22395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E8A47_RS22400	COG0352	thiamine-phosphate diphosphorylase activity
E8A47_RS22405	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E8A47_RS22410	COG0653	protein targeting
E8A47_RS22425	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E8A47_RS22445	COG1181	Belongs to the D-alanine--D-alanine ligase family
E8A47_RS22450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E8A47_RS22455	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E8A47_RS22460	COG0772	Belongs to the SEDS family
E8A47_RS22465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E8A47_RS22470	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E8A47_RS22475	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E8A47_RS22490	COG3116	cell division
E8A47_RS22495	COG0275	rRNA processing
E8A47_RS22505	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E8A47_RS22515	COG0792	nuclease activity
E8A47_RS22520	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E8A47_RS22525	COG2823	Periplasmic or secreted lipoprotein
E8A47_RS22530	COG2969	positive regulation of protein catabolic process
E8A47_RS22535	COG0625	glutathione transferase activity
E8A47_RS22540	COG2857	Cytochrome c1
E8A47_RS22545	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E8A47_RS22550	COG0723	plastoquinol--plastocyanin reductase activity
E8A47_RS22560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E8A47_RS22565	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E8A47_RS22570	COG3105	Protein conserved in bacteria
E8A47_RS22580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E8A47_RS22590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E8A47_RS22595	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E8A47_RS22600	COG5007	Belongs to the BolA IbaG family
E8A47_RS22615	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E8A47_RS22620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E8A47_RS22625	COG1127	ABC transporter
E8A47_RS22635	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E8A47_RS22645	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E8A47_RS22650	COG1137	ATPase activity
E8A47_RS22670	COG1660	Displays ATPase and GTPase activities
E8A47_RS22675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E8A47_RS22680	COG0312	modulator of DNA gyrase
E8A47_RS22685	COG3028	Belongs to the UPF0307 family
E8A47_RS22690	COG0312	modulator of DNA gyrase
E8A47_RS22705	COG0424	maF-like protein
E8A47_RS22710	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E8A47_RS22715	COG1792	Involved in formation and maintenance of cell shape
E8A47_RS22720	COG1077	Cell shape determining protein MreB Mrl
E8A47_RS22725	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E8A47_RS22730	COG0154	amidase activity
E8A47_RS22735	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E8A47_RS22740	COG2062	phosphohistidine phosphatase, SixA
E8A47_RS22750	COG0326	Molecular chaperone. Has ATPase activity
E8A47_RS22760	COG0741	lytic transglycosylase activity
E8A47_RS22770	COG1278	Cold shock
E8A47_RS22780	COG1597	lipid kinase activity
E8A47_RS22785	COG0308	aminopeptidase N
E8A47_RS22790	COG1666	GTP binding
E8A47_RS22795	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E8A47_RS22800	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E8A47_RS22805	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E8A47_RS22810	COG0330	HflC and HflK could
E8A47_RS22815	COG0330	HflC and HflK could
E8A47_RS22820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E8A47_RS22825	COG1923	regulation of RNA biosynthetic process
E8A47_RS22830	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E8A47_RS22835	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E8A47_RS22840	COG0860	N-Acetylmuramoyl-L-alanine amidase
E8A47_RS22845	COG0802	atpase or kinase
E8A47_RS22850	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E8A47_RS22850	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E8A47_RS22860	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E8A47_RS22875	COG1063	alcohol dehydrogenase
E8A47_RS22880	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS22885	COG4948	Mandelate Racemase Muconate Lactonizing
E8A47_RS22890	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS22905	COG1162	GTPase activity
E8A47_RS22915	COG0688	phosphatidylethanolamine metabolic process
E8A47_RS22920	COG1309	transcriptional regulator
E8A47_RS22935	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E8A47_RS22940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E8A47_RS22945	COG1509	lysine 2,3-aminomutase activity
E8A47_RS22955	COG4993	Dehydrogenase
E8A47_RS22975	COG2111	Na H antiporter
E8A47_RS22975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E8A47_RS22980	COG1006	Multisubunit Na H antiporter MnhC subunit
E8A47_RS22985	COG0651	ATP synthesis coupled electron transport
E8A47_RS22990	COG1863	multisubunit Na H antiporter MnhE subunit
E8A47_RS22995	COG2212	antiporter activity
E8A47_RS23000	COG1320	monovalent cation:proton antiporter activity
E8A47_RS23005	COG3830	Belongs to the UPF0237 family
E8A47_RS23005	COG0560	Phosphoserine phosphatase
E8A47_RS23025	COG0166	Belongs to the GPI family
E8A47_RS23030	COG4106	trans-aconitate 2-methyltransferase activity
E8A47_RS23035	COG0500	methyltransferase
E8A47_RS23045	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E8A47_RS23055	COG2738	Putative neutral zinc metallopeptidase
E8A47_RS23065	COG0693	protein deglycase activity
E8A47_RS23080	COG1126	abc transporter atp-binding protein
E8A47_RS23090	COG2895	sulfate adenylyltransferase (ATP) activity
E8A47_RS23095	COG0175	sulfate reduction
E8A47_RS23100	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E8A47_RS23105	COG3151	Protein conserved in bacteria
E8A47_RS23110	COG0494	nUDIX hydrolase
E8A47_RS23120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E8A47_RS23130	COG1063	alcohol dehydrogenase
E8A47_RS23140	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS23145	COG2186	Transcriptional regulator
E8A47_RS23150	COG2813	Specifically methylates the guanine in position
E8A47_RS23175	COG1609	Transcriptional regulator
E8A47_RS23180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E8A47_RS23190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E8A47_RS23195	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS23205	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS23205	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E8A47_RS23215	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS23230	COG1737	Transcriptional regulator
E8A47_RS23235	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E8A47_RS23245	COG4145	pantothenate transmembrane transporter activity
E8A47_RS23250	COG0246	Mannitol dehydrogenase
E8A47_RS23255	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS23260	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E8A47_RS23265	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS23270	COG1063	alcohol dehydrogenase
E8A47_RS23275	COG4948	Mandelate Racemase Muconate Lactonizing
E8A47_RS23280	COG1904	glucuronate isomerase
E8A47_RS23285	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E8A47_RS23285	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E8A47_RS23295	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E8A47_RS23300	COG1802	Transcriptional regulator
E8A47_RS23310	COG4181	ATPase activity
E8A47_RS23315	COG0577	efflux transmembrane transporter activity
E8A47_RS23325	COG3246	L-lysine catabolic process to acetate
E8A47_RS23340	COG0657	acetylesterase activity
E8A47_RS23355	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E8A47_RS23380	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E8A47_RS23400	COG3871	stress protein (general stress protein 26)
E8A47_RS23405	COG2340	Cysteine-rich secretory protein family
E8A47_RS23410	COG3045	CreA protein
E8A47_RS23430	COG2056	Na+-H+ antiporter family
E8A47_RS23435	COG2986	histidine ammonia-lyase
E8A47_RS23445	COG0010	Belongs to the arginase family
E8A47_RS23450	COG1228	amidohydrolase
E8A47_RS23455	COG3314	Sporulation integral membrane protein YlbJ
E8A47_RS23500	COG2153	protein acetylation
E8A47_RS23535	COG3039	Transposase
E8A47_RS23540	COG2153	protein acetylation
E8A47_RS23590	COG0582	viral genome integration into host DNA
E8A47_RS23605	COG3300	MHYT domain
E8A47_RS23605	COG5001	Diguanylate cyclase
E8A47_RS23625	COG1368	sulfuric ester hydrolase activity
E8A47_RS23630	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS23630	COG3321	synthase
E8A47_RS23630	COG0604	alcohol dehydrogenase
E8A47_RS23635	COG0156	8-amino-7-oxononanoate synthase activity
E8A47_RS23645	COG1943	Transposase
E8A47_RS23665	COG0175	sulfate reduction
E8A47_RS23675	COG3273	potassium ion transport
E8A47_RS23675	COG0471	metal ion transport
E8A47_RS23685	COG0033	Phosphoglucomutase
E8A47_RS23705	COG1216	Glycosyl transferase, family 2
E8A47_RS23705	COG0438	transferase activity, transferring glycosyl groups
E8A47_RS23720	COG1216	Glycosyl transferase, family 2
E8A47_RS23735	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E8A47_RS23755	COG1216	Glycosyl transferase, family 2
E8A47_RS23790	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E8A47_RS23800	COG1088	dTDP-glucose 4,6-dehydratase activity
E8A47_RS23810	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E8A47_RS23880	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E8A47_RS23885	COG0730	response to heat
E8A47_RS23890	COG0745	RESPONSE REGULATOR receiver
E8A47_RS23925	COG0039	L-malate dehydrogenase activity
E8A47_RS23950	COG1028	Short-chain dehydrogenase reductase Sdr
E8A47_RS23960	COG1250	3-hydroxyacyl-CoA dehydrogenase
E8A47_RS23960	COG1024	Enoyl-CoA hydratase
E8A47_RS23965	COG1960	acyl-CoA dehydrogenase activity
E8A47_RS23990	COG1129	ABC transporter
E8A47_RS24005	COG0251	oxidation-reduction process
E8A47_RS24015	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E8A47_RS24025	COG2183	response to ionizing radiation
E8A47_RS24035	COG0583	DNA-binding transcription factor activity
E8A47_RS24050	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E8A47_RS24055	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E8A47_RS24060	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E8A47_RS24065	COG1011	Hydrolase
E8A47_RS24070	COG0494	nUDIX hydrolase
E8A47_RS24075	COG0673	inositol 2-dehydrogenase activity
E8A47_RS24080	COG0129	dihydroxy-acid dehydratase activity
E8A47_RS24085	COG0840	transmembrane signaling receptor activity
E8A47_RS24085	COG0840	transmembrane signaling receptor activity
E8A47_RS24090	COG0840	transmembrane signaling receptor activity
E8A47_RS24090	COG0840	transmembrane signaling receptor activity
E8A47_RS24095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E8A47_RS24105	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E8A47_RS24110	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E8A47_RS24115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E8A47_RS24120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E8A47_RS24130	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E8A47_RS24130	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E8A47_RS24135	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E8A47_RS24140	COG0366	Alpha amylase catalytic
E8A47_RS24150	COG3258	Cytochrome c
E8A47_RS24155	COG2863	cytochrome
E8A47_RS24160	COG0642	Histidine kinase
E8A47_RS24170	COG2391	methyltransferase activity
E8A47_RS24185	COG0840	transmembrane signaling receptor activity
E8A47_RS24195	COG1215	transferase activity, transferring glycosyl groups
E8A47_RS24205	COG1360	Flagellar Motor Protein
E8A47_RS24255	COG0463	Glycosyl transferase, family 2
E8A47_RS24325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8A47_RS24335	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E8A47_RS24350	COG0733	neurotransmitter:sodium symporter activity
E8A47_RS24355	COG0477	Major facilitator Superfamily
E8A47_RS24380	COG0583	DNA-binding transcription factor activity
E8A47_RS24395	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins