locus-tag	class	description
DU500_RS00010	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DU500_RS00025	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DU500_RS00030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DU500_RS00070	COG0358	DNA primase activity
DU500_RS00105	COG2860	membrane
DU500_RS00115	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DU500_RS00125	COG0083	homoserine kinase activity
DU500_RS00155	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DU500_RS00160	COG2154	pterin-4-alpha-carbinolamine dehydratase
DU500_RS00180	COG0303	'Molybdopterin
DU500_RS00185	COG0303	'Molybdopterin
DU500_RS00195	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DU500_RS00210	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DU500_RS00225	COG1899	peptidyl-lysine modification to peptidyl-hypusine
DU500_RS00230	COG0003	Pfam Anion-transporting ATPase
DU500_RS00245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DU500_RS00250	COG1278	Cold shock
DU500_RS00255	COG4948	Mandelate Racemase Muconate Lactonizing
DU500_RS00280	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DU500_RS00305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DU500_RS00320	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DU500_RS00340	COG1028	Short-chain dehydrogenase reductase Sdr
DU500_RS00375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DU500_RS00415	COG3383	formate dehydrogenase (NAD+) activity
DU500_RS00425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DU500_RS00465	COG2084	Dehydrogenase
DU500_RS00470	COG1058	Belongs to the CinA family
DU500_RS00470	COG1546	Belongs to the CinA family
DU500_RS00475	COG0012	GTP binding
DU500_RS00525	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DU500_RS00530	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DU500_RS00575	COG0346	lactoylglutathione lyase activity
DU500_RS00595	COG3833	ABC-type maltose transport systems, permease component
DU500_RS00600	COG3842	ATPase activity
DU500_RS00620	COG4948	Mandelate Racemase Muconate Lactonizing
DU500_RS00630	COG1477	protein flavinylation
DU500_RS00710	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DU500_RS00710	COG0519	Catalyzes the synthesis of GMP from XMP
DU500_RS00715	COG0504	CTP synthase activity
DU500_RS00745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DU500_RS00755	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DU500_RS00775	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DU500_RS00780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DU500_RS00810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DU500_RS00820	COG2339	peptidase activity
DU500_RS00850	COG0210	DNA helicase
DU500_RS00865	COG1914	H( )-stimulated, divalent metal cation uptake system
DU500_RS00875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DU500_RS00900	COG0488	(ABC) transporter
DU500_RS00905	COG1228	amidohydrolase
DU500_RS00910	COG0284	orotidine-5'-phosphate decarboxylase activity
DU500_RS00920	COG0071	Belongs to the small heat shock protein (HSP20) family
DU500_RS00940	COG0430	RNA-3'-phosphate cyclase activity
DU500_RS00950	COG3276	selenocysteine insertion sequence binding
DU500_RS00955	COG0501	Belongs to the peptidase M48B family
DU500_RS00965	COG4608	Belongs to the ABC transporter superfamily
DU500_RS00970	COG0444	Belongs to the ABC transporter superfamily
DU500_RS00980	COG0601	transmembrane transport
DU500_RS00985	COG0747	negative chemotaxis
DU500_RS01005	COG0530	calcium, potassium:sodium antiporter activity
DU500_RS01025	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DU500_RS01030	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DU500_RS01045	COG0563	adenylate kinase activity
DU500_RS01050	COG0538	isocitrate dehydrogenase activity
DU500_RS01065	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DU500_RS01085	COG1028	Short-chain dehydrogenase reductase Sdr
DU500_RS01115	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DU500_RS01130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DU500_RS01155	COG0557	exoribonuclease II activity
DU500_RS01170	COG0051	transcription antitermination factor activity, RNA binding
DU500_RS01175	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DU500_RS01180	COG0460	homoserine dehydrogenase
DU500_RS01195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DU500_RS01205	COG1454	alcohol dehydrogenase
DU500_RS01210	COG0049	tRNA binding
DU500_RS01230	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DU500_RS01235	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DU500_RS01240	COG0085	RNA polymerase activity
DU500_RS01305	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DU500_RS01320	COG0531	amino acid
DU500_RS01330	COG1522	sequence-specific DNA binding
DU500_RS01350	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DU500_RS01360	COG2201	protein-glutamate methylesterase activity
DU500_RS01375	COG0126	phosphoglycerate kinase activity
DU500_RS01385	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DU500_RS01395	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DU500_RS01400	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DU500_RS01430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DU500_RS01440	COG0277	FAD linked oxidase domain protein
DU500_RS01440	COG0247	lactate metabolic process
DU500_RS01445	COG0589	response to stress
DU500_RS01450	COG1024	Enoyl-CoA hydratase
DU500_RS01460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DU500_RS01475	COG0745	RESPONSE REGULATOR receiver
DU500_RS01490	COG0351	phosphomethylpyrimidine kinase
DU500_RS01495	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DU500_RS01505	COG0492	ferredoxin-NADP+ reductase activity
DU500_RS01510	COG2154	pterin-4-alpha-carbinolamine dehydratase
DU500_RS01515	COG1047	Peptidyl-prolyl cis-trans
DU500_RS01520	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DU500_RS01545	COG0442	prolyl-tRNA aminoacylation
DU500_RS01570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DU500_RS01630	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DU500_RS01640	COG0459	protein refolding
DU500_RS01675	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DU500_RS01685	COG0402	S-adenosylhomocysteine deaminase activity
DU500_RS01700	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DU500_RS01735	COG0688	phosphatidylethanolamine metabolic process
DU500_RS01745	COG1234	tRNA 3'-trailer cleavage
DU500_RS01790	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DU500_RS01795	COG0109	protoheme IX farnesyltransferase activity
DU500_RS01810	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DU500_RS01875	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DU500_RS01910	COG1132	(ABC) transporter
DU500_RS01990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DU500_RS01995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DU500_RS02005	COG3119	arylsulfatase activity
DU500_RS02020	COG0009	L-threonylcarbamoyladenylate synthase
DU500_RS02035	COG1253	flavin adenine dinucleotide binding
DU500_RS02040	COG0306	phosphate transporter
DU500_RS02065	COG2309	aminopeptidase activity
DU500_RS02085	COG1295	ribonuclease BN
DU500_RS02110	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
DU500_RS02120	COG1960	acyl-CoA dehydrogenase activity
DU500_RS02145	COG0247	lactate metabolic process
DU500_RS02145	COG2181	nitrate reductase activity
DU500_RS02150	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DU500_RS02155	COG1122	ATPase activity
DU500_RS02160	COG1268	BioY protein
DU500_RS02170	COG1372	Participates in initiation and elongation during chromosome replication
DU500_RS02170	COG0305	Participates in initiation and elongation during chromosome replication
DU500_RS02205	COG1733	regulation of RNA biosynthetic process
DU500_RS02220	COG0435	Glutathione S-transferase
DU500_RS02235	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DU500_RS02275	COG1573	uracil-dna glycosylase
DU500_RS02280	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DU500_RS02290	COG0519	Catalyzes the synthesis of GMP from XMP
DU500_RS02290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DU500_RS02315	COG0470	DNA polymerase III
DU500_RS02320	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DU500_RS02335	COG1028	Short-chain dehydrogenase reductase Sdr
DU500_RS02340	COG1250	3-hydroxyacyl-CoA dehydrogenase
DU500_RS02355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DU500_RS02365	COG0131	Imidazoleglycerol-phosphate dehydratase
DU500_RS02370	COG1045	serine acetyltransferase
DU500_RS02375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DU500_RS02390	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DU500_RS02420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DU500_RS02430	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DU500_RS02450	COG1012	belongs to the aldehyde dehydrogenase family
DU500_RS02465	COG0395	ABC-type sugar transport system, permease component
DU500_RS02470	COG1176	ABC-type spermidine putrescine transport system, permease component I
DU500_RS02475	COG3842	ATPase activity
DU500_RS02485	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DU500_RS02505	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DU500_RS02515	COG0702	epimerase
DU500_RS02545	COG0501	Belongs to the peptidase M48B family
DU500_RS02570	COG0822	iron-sulfur transferase activity
DU500_RS02595	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DU500_RS02625	COG3852	Histidine kinase
DU500_RS02630	COG0805	protein transport
DU500_RS02635	COG0805	protein transport
DU500_RS02645	COG1606	tRNA processing
DU500_RS02655	COG1121	(ABC) transporter
DU500_RS02665	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DU500_RS02680	COG2226	methyltransferase
DU500_RS02700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DU500_RS02710	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DU500_RS02715	COG2301	Belongs to the HpcH HpaI aldolase family
DU500_RS02760	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DU500_RS02770	COG1691	(AIR) carboxylase
DU500_RS02775	COG2827	Endonuclease containing a URI domain
DU500_RS02780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DU500_RS02825	COG0523	cobalamin synthesis protein
DU500_RS02835	COG0003	Pfam Anion-transporting ATPase
DU500_RS02840	COG1966	Carbon starvation protein
DU500_RS02885	COG0039	L-malate dehydrogenase activity
DU500_RS02890	COG0322	excinuclease ABC activity
DU500_RS02925	COG2873	o-acetylhomoserine
DU500_RS02930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DU500_RS02960	COG2873	o-acetylhomoserine
DU500_RS02965	COG0252	asparaginase activity
DU500_RS02970	COG0560	Phosphoserine phosphatase
DU500_RS02975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DU500_RS02990	COG3361	conserved protein (COG2071)
DU500_RS02995	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DU500_RS03020	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DU500_RS03035	COG1648	precorrin-2 dehydrogenase activity
DU500_RS03035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DU500_RS03045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DU500_RS03050	COG1648	precorrin-2 dehydrogenase activity
DU500_RS03050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DU500_RS03060	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DU500_RS03075	COG0656	L-ascorbic acid biosynthetic process
DU500_RS03145	COG0589	response to stress
DU500_RS03150	COG2814	Major facilitator Superfamily
DU500_RS03160	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DU500_RS03170	COG0642	Histidine kinase
DU500_RS03180	COG1757	Na H antiporter
DU500_RS03195	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DU500_RS03195	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DU500_RS03200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DU500_RS03200	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DU500_RS03205	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DU500_RS03220	COG0436	Aminotransferase
DU500_RS03225	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DU500_RS03240	COG0515	serine threonine protein kinase
DU500_RS03240	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DU500_RS03300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DU500_RS03310	COG2205	protein histidine kinase activity
DU500_RS03325	COG0527	aspartate kinase activity
DU500_RS03330	COG3383	formate dehydrogenase (NAD+) activity
DU500_RS03355	COG1160	GTP binding
DU500_RS03395	COG2897	thiosulfate sulfurtransferase activity
DU500_RS03410	COG0471	metal ion transport
DU500_RS03410	COG3273	potassium ion transport
DU500_RS03425	COG1028	Short-chain dehydrogenase reductase Sdr
DU500_RS03435	COG0556	nucleotide-excision repair
DU500_RS03440	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DU500_RS03495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DU500_RS03500	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DU500_RS03505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DU500_RS03510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DU500_RS03515	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DU500_RS03520	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DU500_RS03525	COG0189	ligase activity
DU500_RS03530	COG0137	argininosuccinate synthase activity
DU500_RS03550	COG0423	glycine-tRNA ligase activity
DU500_RS03620	COG0181	hydroxymethylbilane synthase activity
DU500_RS03625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DU500_RS03630	COG0004	ammonium transporteR
DU500_RS03635	COG0113	porphobilinogen synthase activity
DU500_RS03680	COG4191	Histidine kinase
DU500_RS03685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DU500_RS03730	COG0525	valine-tRNA ligase activity
DU500_RS03745	COG0167	dihydroorotate dehydrogenase activity
DU500_RS03810	COG1132	(ABC) transporter
DU500_RS03815	COG4191	Histidine kinase
DU500_RS03815	COG0784	Response regulator, receiver
DU500_RS03840	COG0464	growth
DU500_RS03850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DU500_RS03855	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DU500_RS03880	COG0668	transmembrane transport
DU500_RS03885	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DU500_RS03905	COG1305	Transglutaminase-like
DU500_RS03920	COG0714	Associated with various cellular activities
DU500_RS03930	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DU500_RS03950	COG1185	polyribonucleotide nucleotidyltransferase activity
DU500_RS03965	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DU500_RS04030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DU500_RS04060	COG2133	pyrroloquinoline quinone binding
DU500_RS04100	COG0531	amino acid
DU500_RS04115	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DU500_RS04120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DU500_RS04130	COG2205	protein histidine kinase activity
DU500_RS04150	COG0667	Aldo Keto reductase
DU500_RS04190	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DU500_RS04235	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DU500_RS04240	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DU500_RS04270	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DU500_RS04275	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DU500_RS04280	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DU500_RS04340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DU500_RS04370	COG0633	Ferredoxin
DU500_RS04380	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DU500_RS04475	COG0585	pseudouridine synthase activity
DU500_RS04530	COG3608	succinylglutamate desuccinylase aspartoacylase
DU500_RS04565	COG2252	PERMEase
DU500_RS04570	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DU500_RS04575	COG1136	(ABC) transporter
DU500_RS04575	COG0577	efflux transmembrane transporter activity
DU500_RS04580	COG0577	efflux transmembrane transporter activity
DU500_RS04580	COG1136	(ABC) transporter
DU500_RS04620	COG4191	Histidine kinase
DU500_RS04630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DU500_RS04670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DU500_RS04765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DU500_RS04770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DU500_RS04780	COG0864	Transcriptional regulator
DU500_RS04785	COG1335	isochorismatase
DU500_RS04810	COG1269	ATP hydrolysis coupled proton transport
DU500_RS04835	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
DU500_RS04885	COG2894	cell division
DU500_RS04910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DU500_RS04945	COG1278	Cold shock
DU500_RS05010	COG1131	(ABC) transporter
DU500_RS05015	COG0842	Transport permease protein
DU500_RS05020	COG0616	signal peptide processing
DU500_RS05035	COG0601	transmembrane transport
DU500_RS05040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DU500_RS05130	COG0047	phosphoribosylformylglycinamidine synthase activity
DU500_RS05140	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DU500_RS05145	COG1164	Oligoendopeptidase f
DU500_RS05175	COG4974	Belongs to the 'phage' integrase family
DU500_RS05195	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DU500_RS05215	COG1063	alcohol dehydrogenase
DU500_RS05220	COG2146	nitrite reductase [NAD(P)H] activity
DU500_RS05295	COG1366	Belongs to the anti-sigma-factor antagonist family
DU500_RS05295	COG2202	Pas domain
DU500_RS05310	COG0028	Belongs to the TPP enzyme family
DU500_RS05330	COG2721	sulfolactate sulfo-lyase activity
DU500_RS05335	COG2721	sulfolactate sulfo-lyase activity
DU500_RS05340	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DU500_RS05360	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DU500_RS05365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DU500_RS05370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DU500_RS05370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DU500_RS05380	COG2267	carboxylic ester hydrolase activity
DU500_RS05400	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
DU500_RS05410	COG1131	(ABC) transporter
DU500_RS05445	COG1881	PFAM PEBP family protein
DU500_RS05485	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DU500_RS05495	COG3118	belongs to the thioredoxin family
DU500_RS05500	COG0596	Alpha beta hydrolase
DU500_RS05500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DU500_RS05500	COG2226	methyltransferase
DU500_RS05530	COG0142	geranyltranstransferase activity
DU500_RS05545	COG0519	Catalyzes the synthesis of GMP from XMP
DU500_RS05545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DU500_RS05590	COG0528	UMP kinase activity
DU500_RS05595	COG0314	molybdopterin synthase activity
DU500_RS05610	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DU500_RS05635	COG0746	molybdenum cofactor guanylyltransferase activity
DU500_RS05640	COG0101	tRNA pseudouridine synthase activity
DU500_RS05650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DU500_RS05650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DU500_RS05655	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DU500_RS05660	COG0124	histidyl-tRNA synthetase
DU500_RS05680	COG0166	Belongs to the GPI family
DU500_RS05695	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DU500_RS05705	COG0309	Hydrogenase expression formation protein (HypE)
DU500_RS05715	COG0596	Alpha beta hydrolase
DU500_RS05730	COG0714	Associated with various cellular activities
DU500_RS05750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DU500_RS05765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DU500_RS05770	COG2226	methyltransferase
DU500_RS05800	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DU500_RS05820	COG4106	trans-aconitate 2-methyltransferase activity
DU500_RS05865	COG1063	alcohol dehydrogenase
DU500_RS05875	COG2205	protein histidine kinase activity
DU500_RS05885	COG1053	succinate dehydrogenase
DU500_RS05925	COG3920	Histidine kinase
DU500_RS05985	COG4948	Mandelate Racemase Muconate Lactonizing
DU500_RS06035	COG0028	Belongs to the TPP enzyme family
DU500_RS06050	COG5002	protein histidine kinase activity
DU500_RS06060	COG0412	Dienelactone hydrolase
DU500_RS06070	COG4191	Histidine kinase
DU500_RS06075	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DU500_RS06085	COG0473	3-isopropylmalate dehydrogenase activity
DU500_RS06110	COG4656	Part of a membrane complex involved in electron transport
DU500_RS06115	COG0656	L-ascorbic acid biosynthetic process
DU500_RS06135	COG0415	Belongs to the DNA photolyase family
DU500_RS06145	COG3794	PFAM blue (type 1) copper domain protein
DU500_RS06150	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DU500_RS06155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DU500_RS06230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DU500_RS06235	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DU500_RS06245	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DU500_RS06250	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DU500_RS06275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DU500_RS06280	COG0037	tRNA processing
DU500_RS06315	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DU500_RS06325	COG0095	Lipoate-protein ligase
DU500_RS06335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DU500_RS06340	COG0444	Belongs to the ABC transporter superfamily
DU500_RS06345	COG4608	Belongs to the ABC transporter superfamily
DU500_RS06350	COG0601	transmembrane transport
DU500_RS06360	COG3852	Histidine kinase
DU500_RS06390	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DU500_RS06395	COG0573	inorganic phosphate transmembrane transporter activity
DU500_RS06400	COG0581	inorganic phosphate transmembrane transporter activity
DU500_RS06405	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DU500_RS06410	COG0704	Plays a role in the regulation of phosphate uptake
DU500_RS06420	COG0517	IMP dehydrogenase activity
DU500_RS06425	COG0492	ferredoxin-NADP+ reductase activity
DU500_RS06455	COG4948	Mandelate Racemase Muconate Lactonizing
DU500_RS06465	COG2414	aldehyde ferredoxin oxidoreductase
DU500_RS06480	COG0517	IMP dehydrogenase activity
DU500_RS06490	COG0330	HflC and HflK could
DU500_RS06515	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DU500_RS06540	COG0596	Alpha beta hydrolase
DU500_RS06555	COG0148	phosphopyruvate hydratase activity
DU500_RS06570	COG1278	Cold shock
DU500_RS06590	COG0501	Belongs to the peptidase M48B family
DU500_RS06605	COG1196	nuclear chromosome segregation
DU500_RS06625	COG1280	lysine exporter protein (LysE YggA)
DU500_RS06640	COG0384	phenazine biosynthesis protein PhzF
DU500_RS06655	COG0435	Glutathione S-transferase
DU500_RS06660	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
DU500_RS06670	COG2226	methyltransferase
DU500_RS06680	COG0717	Belongs to the dCTP deaminase family
DU500_RS06685	COG0372	Belongs to the citrate synthase family
DU500_RS06695	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DU500_RS06700	COG0251	oxidation-reduction process
DU500_RS06725	COG0459	protein refolding
DU500_RS06750	COG0495	leucyl-tRNA aminoacylation
DU500_RS06760	COG0071	Belongs to the small heat shock protein (HSP20) family
DU500_RS06765	COG0077	Prephenate dehydratase
DU500_RS06770	COG5002	protein histidine kinase activity
DU500_RS06775	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DU500_RS06785	COG1803	Methylglyoxal synthase
DU500_RS06805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DU500_RS06870	COG0395	ABC-type sugar transport system, permease component
DU500_RS06880	COG3842	ATPase activity
DU500_RS06895	COG4948	Mandelate Racemase Muconate Lactonizing
DU500_RS06900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DU500_RS06910	COG2205	protein histidine kinase activity
DU500_RS06925	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DU500_RS06930	COG3639	organic phosphonate transmembrane transporter activity
DU500_RS06960	COG1250	3-hydroxyacyl-CoA dehydrogenase
DU500_RS06975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DU500_RS06980	COG1960	acyl-CoA dehydrogenase activity
DU500_RS06995	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DU500_RS07000	COG4166	transmembrane transport
DU500_RS07010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DU500_RS07050	COG0515	serine threonine protein kinase
DU500_RS07050	COG2815	serine threonine protein kinase
DU500_RS07065	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DU500_RS07075	COG4948	Mandelate Racemase Muconate Lactonizing
DU500_RS07080	COG0017	Asparaginyl-tRNA synthetase
DU500_RS07105	COG0436	Aminotransferase
DU500_RS07110	COG2226	methyltransferase
DU500_RS07115	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DU500_RS07115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DU500_RS07120	COG0469	pyruvate kinase activity
DU500_RS07155	COG1546	Belongs to the CinA family
DU500_RS07155	COG1058	Belongs to the CinA family
DU500_RS07215	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DU500_RS07225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DU500_RS07245	COG0419	ATPase involved in DNA repair
DU500_RS07270	COG0396	ATPase activity
DU500_RS07275	COG0719	Fe-S assembly protein
DU500_RS07280	COG0719	Fe-S assembly protein
DU500_RS07400	COG1968	undecaprenyl-diphosphatase activity
DU500_RS07420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DU500_RS07435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DU500_RS07460	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DU500_RS07470	COG1404	Belongs to the peptidase S8 family
DU500_RS07475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DU500_RS07480	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DU500_RS07495	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DU500_RS07525	COG1045	serine acetyltransferase
DU500_RS07530	COG0673	inositol 2-dehydrogenase activity
DU500_RS07540	COG0438	transferase activity, transferring glycosyl groups
DU500_RS07565	COG1132	(ABC) transporter
DU500_RS07680	COG4191	Histidine kinase
DU500_RS07685	COG1458	PINc domain ribonuclease
DU500_RS07865	COG0864	Transcriptional regulator
DU500_RS07875	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DU500_RS07895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DU500_RS07900	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DU500_RS07925	COG1414	Transcriptional regulator
DU500_RS07930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DU500_RS07940	COG1012	belongs to the aldehyde dehydrogenase family
DU500_RS08005	COG0183	Belongs to the thiolase family
DU500_RS08015	COG1028	Short-chain dehydrogenase reductase Sdr
DU500_RS08025	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DU500_RS08030	COG1796	DNA polymerase
DU500_RS08030	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DU500_RS08055	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DU500_RS08065	COG1113	amino acid transport
DU500_RS08120	COG3273	potassium ion transport
DU500_RS08120	COG0471	metal ion transport
DU500_RS08135	COG0589	response to stress
DU500_RS08175	COG1414	Transcriptional regulator
DU500_RS08190	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DU500_RS08195	COG3648	Uricase
DU500_RS08195	COG3195	allantoin biosynthetic process
DU500_RS08200	COG3195	allantoin biosynthetic process
DU500_RS08200	COG3648	Uricase
DU500_RS08220	COG0402	S-adenosylhomocysteine deaminase activity
DU500_RS08225	COG2252	PERMEase
DU500_RS08240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DU500_RS08240	COG2080	2 iron, 2 sulfur cluster binding
DU500_RS08260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DU500_RS08275	COG0494	nUDIX hydrolase
DU500_RS08295	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DU500_RS08315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DU500_RS08340	COG1968	undecaprenyl-diphosphatase activity
DU500_RS08350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DU500_RS08410	COG0070	glutamate synthase
DU500_RS08410	COG0069	glutamate synthase activity
DU500_RS08410	COG0067	glutamate synthase
DU500_RS08415	COG0442	prolyl-tRNA aminoacylation
DU500_RS08420	COG1515	deoxyribonuclease V activity
DU500_RS08430	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DU500_RS08445	COG0328	RNA-DNA hybrid ribonuclease activity
DU500_RS08455	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DU500_RS08470	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DU500_RS08500	COG0303	'Molybdopterin
DU500_RS08505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DU500_RS08560	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DU500_RS08560	COG1796	DNA polymerase
DU500_RS08575	COG0463	Glycosyl transferase, family 2
DU500_RS08615	COG0459	protein refolding
DU500_RS08650	COG0134	indole-3-glycerol-phosphate synthase activity
DU500_RS08655	COG0133	tryptophan synthase activity
DU500_RS08660	COG0159	tryptophan synthase activity
DU500_RS08665	COG1830	Aldolase
DU500_RS08670	COG1465	3-dehydroquinate synthase
DU500_RS08700	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DU500_RS08700	COG2124	cytochrome p450
DU500_RS08715	COG0494	nUDIX hydrolase
DU500_RS08725	COG1215	transferase activity, transferring glycosyl groups
DU500_RS08740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DU500_RS08790	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DU500_RS08810	COG0330	HflC and HflK could
DU500_RS08815	COG0402	S-adenosylhomocysteine deaminase activity
DU500_RS08820	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DU500_RS08855	COG0438	transferase activity, transferring glycosyl groups
DU500_RS08870	COG0668	transmembrane transport
DU500_RS08880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DU500_RS08885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DU500_RS08900	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DU500_RS08905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DU500_RS08920	COG0459	protein refolding
DU500_RS08930	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
DU500_RS08970	COG0277	FAD linked oxidase domain protein
DU500_RS09050	COG0556	nucleotide-excision repair
DU500_RS09210	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DU500_RS09225	COG0647	UMP catabolic process
DU500_RS09235	COG0531	amino acid
DU500_RS09245	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DU500_RS09250	COG0179	Fumarylacetoacetate (FAA) hydrolase
DU500_RS09280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DU500_RS09290	COG1213	nucleotidyl transferase
DU500_RS09290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DU500_RS09315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DU500_RS09320	COG1522	sequence-specific DNA binding
DU500_RS09325	COG1013	pyruvate-flavodoxin oxidoreductase activity
DU500_RS09330	COG0674	pyruvate-flavodoxin oxidoreductase activity
DU500_RS09330	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DU500_RS09340	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DU500_RS09345	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DU500_RS09350	COG4191	Histidine kinase
DU500_RS09355	COG0371	Dehydrogenase
DU500_RS09365	COG0589	response to stress
DU500_RS09395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DU500_RS09395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DU500_RS09405	COG0596	Alpha beta hydrolase
DU500_RS09415	COG0183	Belongs to the thiolase family
DU500_RS09420	COG4935	Belongs to the peptidase S8 family
DU500_RS09420	COG2234	aminopeptidase activity
DU500_RS09445	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DU500_RS09450	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DU500_RS09475	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DU500_RS09495	COG1605	Chorismate mutase
DU500_RS09495	COG0287	Prephenate dehydrogenase
DU500_RS09530	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DU500_RS09575	COG2119	membrane
DU500_RS09580	COG1321	iron dependent repressor
DU500_RS09590	COG1233	COG1233 Phytoene dehydrogenase and related
DU500_RS09635	COG1185	polyribonucleotide nucleotidyltransferase activity
DU500_RS09655	COG1234	tRNA 3'-trailer cleavage
DU500_RS09660	COG0589	response to stress
DU500_RS09670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DU500_RS09715	COG0506	proline dehydrogenase activity
DU500_RS09720	COG1012	belongs to the aldehyde dehydrogenase family
DU500_RS09760	COG0003	Pfam Anion-transporting ATPase
DU500_RS09765	COG4221	oxidoreductase activity
DU500_RS09775	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DU500_RS09800	COG0616	signal peptide processing
DU500_RS09810	COG0656	L-ascorbic acid biosynthetic process
DU500_RS09820	COG0471	metal ion transport
DU500_RS09835	COG1013	pyruvate-flavodoxin oxidoreductase activity
DU500_RS09840	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DU500_RS09840	COG0674	pyruvate-flavodoxin oxidoreductase activity
DU500_RS09845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DU500_RS09855	COG0456	acetyltransferase
DU500_RS09925	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DU500_RS09945	COG2130	NADP-dependent
DU500_RS09955	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DU500_RS09980	COG0142	geranyltranstransferase activity
DU500_RS10005	COG3290	protein histidine kinase activity
DU500_RS10005	COG0840	transmembrane signaling receptor activity
DU500_RS10015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DU500_RS10030	COG0405	Gamma-glutamyltransferase
DU500_RS10065	COG2124	cytochrome p450
DU500_RS10075	COG0346	lactoylglutathione lyase activity
DU500_RS10085	COG0644	oxidoreductase
DU500_RS10110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DU500_RS10115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DU500_RS10140	COG1444	tRNA N-acetyltransferase activity
DU500_RS10160	COG0105	UTP biosynthetic process
DU500_RS10175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DU500_RS10215	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DU500_RS10235	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DU500_RS10265	COG1252	NADH dehydrogenase
DU500_RS10270	COG0745	RESPONSE REGULATOR receiver
DU500_RS10280	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
DU500_RS10300	COG2894	cell division
DU500_RS10315	COG1047	Peptidyl-prolyl cis-trans
DU500_RS10325	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
DU500_RS10330	COG0301	tRNA thio-modification
DU500_RS10340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DU500_RS10350	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DU500_RS10355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DU500_RS10360	COG1331	Highly conserved protein containing a thioredoxin domain
DU500_RS10365	COG4191	Histidine kinase
DU500_RS10370	COG0667	Aldo Keto reductase
DU500_RS10390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DU500_RS10400	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DU500_RS10400	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DU500_RS10405	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DU500_RS10410	COG0109	protoheme IX farnesyltransferase activity
DU500_RS10445	COG3243	poly(R)-hydroxyalkanoic acid synthase
DU500_RS10475	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DU500_RS10490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DU500_RS10495	COG1120	ATPase activity
DU500_RS10500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DU500_RS10540	COG2205	protein histidine kinase activity
DU500_RS10545	COG2197	response regulator
DU500_RS10550	COG0840	transmembrane signaling receptor activity
DU500_RS10580	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DU500_RS10585	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DU500_RS10610	COG0835	chemotaxis
DU500_RS10620	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
DU500_RS10625	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
DU500_RS10660	COG2201	protein-glutamate methylesterase activity
DU500_RS10670	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DU500_RS10725	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DU500_RS10730	COG2198	Histidine kinase
DU500_RS10730	COG0643	Histidine kinase
DU500_RS10735	COG2201	protein-glutamate methylesterase activity
DU500_RS10740	COG0784	Response regulator, receiver
DU500_RS10740	COG0835	chemotaxis
DU500_RS10795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DU500_RS10805	COG4974	Belongs to the 'phage' integrase family
DU500_RS10815	COG2135	peptidase activity
DU500_RS10865	COG0463	Glycosyl transferase, family 2
DU500_RS10890	COG0012	GTP binding
DU500_RS10895	COG0436	Aminotransferase
DU500_RS10900	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DU500_RS10925	COG2267	carboxylic ester hydrolase activity
DU500_RS10940	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DU500_RS10940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DU500_RS10995	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DU500_RS11010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DU500_RS11025	COG1120	ATPase activity
DU500_RS11030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DU500_RS11040	COG2205	protein histidine kinase activity
DU500_RS11070	COG0346	lactoylglutathione lyase activity
DU500_RS11080	COG0247	lactate metabolic process
DU500_RS11080	COG0277	FAD linked oxidase domain protein
DU500_RS11120	COG4770	biotin carboxylase activity
DU500_RS11130	COG0589	response to stress
DU500_RS11140	COG1078	dGTPase activity
DU500_RS11190	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DU500_RS11225	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DU500_RS11250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DU500_RS11260	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DU500_RS11265	COG1201	RNA secondary structure unwinding
DU500_RS11270	COG3875	lactate racemase activity
DU500_RS11280	COG1028	Short-chain dehydrogenase reductase Sdr
DU500_RS11315	COG5002	protein histidine kinase activity
DU500_RS11320	COG0784	Response regulator, receiver
DU500_RS11325	COG4251	negative regulation of phosphorylation
DU500_RS11330	COG1366	Belongs to the anti-sigma-factor antagonist family
DU500_RS11330	COG2202	Pas domain
DU500_RS11335	COG1492	cobalamin metabolic process
DU500_RS11365	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DU500_RS11380	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DU500_RS11410	COG1401	restriction endodeoxyribonuclease activity
DU500_RS11420	COG0642	Histidine kinase
DU500_RS11450	COG0318	PFAM AMP-dependent synthetase and ligase
DU500_RS11475	COG1028	Short-chain dehydrogenase reductase Sdr
DU500_RS11480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DU500_RS11485	COG1028	Short-chain dehydrogenase reductase Sdr
DU500_RS11495	COG3246	L-lysine catabolic process to acetate
DU500_RS11500	COG0165	Argininosuccinate lyase
DU500_RS11505	COG5000	phosphorelay sensor kinase activity
DU500_RS11530	COG0535	radical SAM domain protein
DU500_RS11560	COG3011	Protein conserved in bacteria
DU500_RS11565	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DU500_RS11570	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DU500_RS11575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DU500_RS11590	COG0215	cysteine-tRNA ligase activity
DU500_RS11600	COG1028	Short-chain dehydrogenase reductase Sdr
DU500_RS11615	COG0492	ferredoxin-NADP+ reductase activity
DU500_RS11665	COG2226	methyltransferase
DU500_RS11695	COG1007	ATP synthesis coupled electron transport
DU500_RS11700	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DU500_RS11730	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DU500_RS11735	COG0649	NAD binding
DU500_RS11740	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DU500_RS11745	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DU500_RS11775	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DU500_RS11780	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DU500_RS11820	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DU500_RS11840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DU500_RS11845	COG0601	transmembrane transport
DU500_RS11855	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DU500_RS11860	COG0651	ATP synthesis coupled electron transport
DU500_RS11865	COG0651	ATP synthesis coupled electron transport
DU500_RS11870	COG0651	ATP synthesis coupled electron transport
DU500_RS11875	COG1006	Multisubunit Na H antiporter MnhC subunit
DU500_RS11880	COG2111	Na H antiporter
DU500_RS11885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DU500_RS11885	COG2111	Na H antiporter
DU500_RS11890	COG1320	monovalent cation:proton antiporter activity
DU500_RS11895	COG2212	antiporter activity
DU500_RS11900	COG1863	multisubunit Na H antiporter MnhE subunit
DU500_RS11905	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DU500_RS11925	COG0569	domain protein
DU500_RS11930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DU500_RS11950	COG0154	amidase activity
DU500_RS11955	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DU500_RS11965	COG1063	alcohol dehydrogenase
DU500_RS11970	COG0523	cobalamin synthesis protein
DU500_RS11975	COG0133	tryptophan synthase activity
DU500_RS11990	COG2226	methyltransferase
DU500_RS11995	COG0587	DNA-directed DNA polymerase activity
DU500_RS12000	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DU500_RS12045	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DU500_RS12055	COG0019	diaminopimelate decarboxylase activity
DU500_RS12065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DU500_RS12110	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DU500_RS12115	COG0436	Aminotransferase
DU500_RS12120	COG4581	dead DEAH box helicase
DU500_RS12130	COG1902	pentaerythritol trinitrate reductase activity
DU500_RS12150	COG3402	PFAM membrane-flanked domain
DU500_RS12165	COG1131	(ABC) transporter
DU500_RS12230	COG1476	TRANSCRIPTIONal
DU500_RS12325	COG0745	RESPONSE REGULATOR receiver
DU500_RS12335	COG4191	Histidine kinase
DU500_RS12355	COG0701	Predicted permease
DU500_RS12430	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DU500_RS12435	COG3268	Saccharopine dehydrogenase
DU500_RS12440	COG0702	epimerase
DU500_RS12460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DU500_RS12520	COG0393	Putative heavy-metal-binding
DU500_RS12550	COG0745	RESPONSE REGULATOR receiver
DU500_RS12565	COG4948	Mandelate Racemase Muconate Lactonizing
DU500_RS12605	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DU500_RS12610	COG0022	dehydrogenase e1 component
DU500_RS12615	COG0508	dehydrogenase complex catalyzes the overall conversion of
DU500_RS12620	COG0508	dehydrogenase complex catalyzes the overall conversion of
DU500_RS12635	COG1271	oxidase subunit
DU500_RS12640	COG1294	oxidase, subunit
DU500_RS12655	COG1247	-acetyltransferase
DU500_RS12660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DU500_RS12665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DU500_RS12670	COG0589	response to stress
DU500_RS12690	COG1131	(ABC) transporter
DU500_RS12720	COG0419	ATPase involved in DNA repair
DU500_RS12740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DU500_RS12770	COG1403	HNH endonuclease
DU500_RS12825	COG0018	arginyl-trna synthetase
DU500_RS12835	COG2264	protein methyltransferase activity
DU500_RS12865	COG1169	isochorismate synthase
DU500_RS12870	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DU500_RS12880	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DU500_RS12895	COG1575	Belongs to the MenA family. Type 1 subfamily
DU500_RS12920	COG0540	Belongs to the ATCase OTCase family
DU500_RS12925	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DU500_RS12940	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DU500_RS12945	COG1830	Aldolase
DU500_RS12960	COG1250	3-hydroxyacyl-CoA dehydrogenase
DU500_RS12970	COG1546	Belongs to the CinA family
DU500_RS12970	COG1058	Belongs to the CinA family
DU500_RS12975	COG1131	(ABC) transporter
DU500_RS12995	COG1832	CoA-binding protein
DU500_RS13005	COG0745	RESPONSE REGULATOR receiver
DU500_RS13050	COG0081	regulation of translation
DU500_RS13055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DU500_RS13075	COG0589	response to stress
DU500_RS13090	COG1902	pentaerythritol trinitrate reductase activity
DU500_RS13100	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DU500_RS13105	COG1363	Peptidase, m42
DU500_RS13150	COG0657	acetylesterase activity
DU500_RS13190	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DU500_RS13195	COG0573	inorganic phosphate transmembrane transporter activity
DU500_RS13200	COG0573	inorganic phosphate transmembrane transporter activity
DU500_RS13205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DU500_RS13210	COG0704	Plays a role in the regulation of phosphate uptake
DU500_RS13250	COG0052	Belongs to the universal ribosomal protein uS2 family
DU500_RS13255	COG0148	phosphopyruvate hydratase activity
DU500_RS13270	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DU500_RS13280	COG0200	Binds to the 23S rRNA
DU500_RS13295	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DU500_RS13300	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DU500_RS13305	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DU500_RS13315	COG0471	metal ion transport
DU500_RS13325	COG0489	protein tyrosine kinase activity
DU500_RS13415	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
DU500_RS13420	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DU500_RS13440	COG1028	Short-chain dehydrogenase reductase Sdr
DU500_RS13450	COG0733	neurotransmitter:sodium symporter activity
DU500_RS13455	COG0733	neurotransmitter:sodium symporter activity
DU500_RS13465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DU500_RS13470	COG3852	Histidine kinase
DU500_RS13495	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DU500_RS13510	COG0443	Heat shock 70 kDa protein
DU500_RS13515	COG0484	heat shock protein binding
DU500_RS13525	COG2031	fatty acid transporter
DU500_RS13560	COG1252	NADH dehydrogenase
DU500_RS13570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DU500_RS13575	COG0010	Belongs to the arginase family
DU500_RS13580	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DU500_RS13585	COG0187	DNA topoisomerase II activity
DU500_RS13615	COG1793	dna ligase
DU500_RS13635	COG0473	3-isopropylmalate dehydrogenase activity
DU500_RS13640	COG0066	3-isopropylmalate dehydratase activity
DU500_RS13645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DU500_RS13655	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DU500_RS13660	COG0440	acetolactate synthase activity
DU500_RS13665	COG0028	Belongs to the TPP enzyme family
DU500_RS13670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DU500_RS13700	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DU500_RS13740	COG0318	PFAM AMP-dependent synthetase and ligase
DU500_RS13755	COG4948	Mandelate Racemase Muconate Lactonizing
DU500_RS13760	COG0589	response to stress
DU500_RS13770	COG0589	response to stress
DU500_RS13775	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DU500_RS13775	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DU500_RS13790	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DU500_RS13840	COG1024	Enoyl-CoA hydratase
DU500_RS13895	COG0644	oxidoreductase
DU500_RS13900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DU500_RS13930	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
DU500_RS13940	COG0492	ferredoxin-NADP+ reductase activity
DU500_RS13945	COG0251	oxidation-reduction process
DU500_RS13990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DU500_RS13990	COG0116	Belongs to the methyltransferase superfamily
DU500_RS14015	COG0783	Belongs to the Dps family
DU500_RS14080	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DU500_RS14105	COG0154	amidase activity
DU500_RS14150	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DU500_RS14200	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DU500_RS14275	COG0589	response to stress
DU500_RS14285	COG0281	malic enzyme
DU500_RS14285	COG0280	phosphate acetyltransferase
DU500_RS14375	COG1254	Belongs to the acylphosphatase family
DU500_RS14380	COG0589	response to stress
DU500_RS14395	COG1136	(ABC) transporter
DU500_RS14400	COG0577	efflux transmembrane transporter activity
DU500_RS14400	COG1136	(ABC) transporter
DU500_RS14405	COG0516	GMP reductase activity
DU500_RS14405	COG0517	IMP dehydrogenase activity
DU500_RS14410	COG0745	RESPONSE REGULATOR receiver
DU500_RS14430	COG0436	Aminotransferase
DU500_RS14460	COG0714	Associated with various cellular activities
DU500_RS14505	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DU500_RS14505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DU500_RS14525	COG0667	Aldo Keto reductase
DU500_RS14530	COG3046	protein related to deoxyribodipyrimidine photolyase
DU500_RS14535	COG1278	Cold shock
DU500_RS14545	COG1988	membrane-bound metal-dependent
DU500_RS14550	COG0668	transmembrane transport
DU500_RS14600	COG1960	acyl-CoA dehydrogenase activity
DU500_RS14620	COG2205	protein histidine kinase activity
DU500_RS14665	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DU500_RS14670	COG0589	response to stress
DU500_RS14685	COG0475	glutathione-regulated potassium exporter activity
DU500_RS14690	COG0490	domain, Protein
DU500_RS14705	COG0318	PFAM AMP-dependent synthetase and ligase
DU500_RS14710	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DU500_RS14725	COG2217	Heavy metal translocating P-type atpase
DU500_RS14740	COG0733	neurotransmitter:sodium symporter activity
DU500_RS14775	COG1074	ATP-dependent DNA helicase activity
DU500_RS14805	COG2988	succinylglutamate desuccinylase activity
DU500_RS14820	COG2766	serine protein kinase
DU500_RS14835	COG2719	SpoVR family
DU500_RS14850	COG5002	protein histidine kinase activity
DU500_RS14890	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DU500_RS14895	COG0088	Forms part of the polypeptide exit tunnel
DU500_RS14905	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DU500_RS14910	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DU500_RS14920	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DU500_RS14940	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DU500_RS14955	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DU500_RS14965	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DU500_RS14970	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DU500_RS14975	COG0322	excinuclease ABC activity
DU500_RS15010	COG2414	aldehyde ferredoxin oxidoreductase
DU500_RS15030	COG0434	BtpA family
DU500_RS15035	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DU500_RS15040	COG3273	potassium ion transport
DU500_RS15040	COG0471	metal ion transport
DU500_RS15105	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DU500_RS15130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DU500_RS15130	COG0512	Glutamine amidotransferase of anthranilate synthase
DU500_RS15135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DU500_RS15140	COG0135	phosphoribosylanthranilate isomerase activity
DU500_RS15170	COG0517	IMP dehydrogenase activity
DU500_RS15170	COG0516	GMP reductase activity
DU500_RS15185	COG0251	oxidation-reduction process
DU500_RS15190	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DU500_RS15195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DU500_RS15215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DU500_RS15220	COG0598	Magnesium transport protein CorA
DU500_RS15230	COG0534	Mate efflux family protein
DU500_RS15245	COG0589	response to stress
DU500_RS15260	COG2379	hydroxypyruvate reductase
DU500_RS15265	COG0783	Belongs to the Dps family
DU500_RS15280	COG1607	acyl-coa hydrolase
DU500_RS15285	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
DU500_RS15290	COG3920	Histidine kinase
DU500_RS15310	COG3291	Pkd domain containing protein
DU500_RS15325	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DU500_RS15330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DU500_RS15335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DU500_RS15345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DU500_RS15355	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DU500_RS15380	COG2226	methyltransferase
DU500_RS15380	COG1073	alpha beta
DU500_RS15400	COG1215	transferase activity, transferring glycosyl groups
DU500_RS15405	COG0438	transferase activity, transferring glycosyl groups
DU500_RS15410	COG0297	glycogen (starch) synthase activity
DU500_RS15465	COG0463	Glycosyl transferase, family 2
DU500_RS15480	COG2814	Major facilitator Superfamily
DU500_RS15485	COG0151	Belongs to the GarS family
DU500_RS15505	COG0110	maltose O-acetyltransferase activity
DU500_RS15530	COG1028	Short-chain dehydrogenase reductase Sdr
DU500_RS15585	COG0437	4 iron, 4 sulfur cluster binding
DU500_RS15610	COG0569	domain protein
DU500_RS15630	COG0114	fumarate hydratase activity
DU500_RS15645	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DU500_RS15650	COG1131	(ABC) transporter
DU500_RS15675	COG3258	Cytochrome c
DU500_RS15685	COG1138	Cytochrome C-type biogenesis protein
DU500_RS15705	COG0668	transmembrane transport
DU500_RS15715	COG3360	Dodecin
DU500_RS15750	COG4221	oxidoreductase activity
DU500_RS15765	COG0719	Fe-S assembly protein
DU500_RS15795	COG1201	RNA secondary structure unwinding
DU500_RS15830	COG3118	belongs to the thioredoxin family
DU500_RS15855	COG3794	PFAM blue (type 1) copper domain protein
DU500_RS15860	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DU500_RS15870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DU500_RS15870	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DU500_RS15910	COG1193	negative regulation of DNA recombination
DU500_RS15965	COG2226	methyltransferase
DU500_RS15975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DU500_RS16015	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DU500_RS16020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DU500_RS16105	COG1674	ftsk spoiiie
DU500_RS16155	COG0509	glycine decarboxylation via glycine cleavage system
DU500_RS16160	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DU500_RS16165	COG3002	Belongs to the UPF0753 family
DU500_RS16170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DU500_RS16175	COG1522	sequence-specific DNA binding
DU500_RS16180	COG3842	ATPase activity
DU500_RS16200	COG2514	catechol 2,3-dioxygenase activity
DU500_RS16255	COG3425	synthase
DU500_RS16275	COG0415	Belongs to the DNA photolyase family
DU500_RS16305	COG0517	IMP dehydrogenase activity
DU500_RS16305	COG0516	GMP reductase activity
DU500_RS16310	COG0668	transmembrane transport
DU500_RS16320	COG0280	phosphate acetyltransferase
DU500_RS16320	COG0281	malic enzyme
DU500_RS16325	COG1612	heme a metabolic process
DU500_RS16335	COG2255	four-way junction helicase activity
DU500_RS16375	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DU500_RS16390	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DU500_RS16420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DU500_RS16425	COG1053	succinate dehydrogenase
DU500_RS16465	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DU500_RS16470	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DU500_RS16480	COG0778	Nitroreductase
DU500_RS16505	COG0252	asparaginase activity
DU500_RS16525	COG0446	pyridine nucleotide-disulphide oxidoreductase
DU500_RS16570	COG1331	Highly conserved protein containing a thioredoxin domain
DU500_RS16625	COG2226	methyltransferase
DU500_RS16670	COG0798	PFAM Bile acid sodium symporter
DU500_RS16675	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DU500_RS16690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DU500_RS16700	COG0745	RESPONSE REGULATOR receiver
DU500_RS16770	COG1620	l-lactate permease
DU500_RS16775	COG0277	FAD linked oxidase domain protein
DU500_RS16775	COG0247	lactate metabolic process
DU500_RS16790	COG1205	dead DEAH box helicase
DU500_RS16790	COG1111	helicase
DU500_RS16795	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DU500_RS16810	COG1178	ABC-type Fe3 transport system permease component
DU500_RS16815	COG3842	ATPase activity
DU500_RS16840	COG1121	(ABC) transporter
DU500_RS16850	COG0129	dihydroxy-acid dehydratase activity
DU500_RS16855	COG0521	Mo-molybdopterin cofactor biosynthetic process
DU500_RS16875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DU500_RS16880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DU500_RS16910	COG0546	phosphoglycolate phosphatase activity
DU500_RS16935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DU500_RS16940	COG0587	DNA-directed DNA polymerase activity
DU500_RS16960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DU500_RS16965	COG0512	Glutamine amidotransferase of anthranilate synthase
DU500_RS16970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DU500_RS16995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DU500_RS17000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DU500_RS17005	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DU500_RS17055	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DU500_RS17080	COG1074	ATP-dependent DNA helicase activity
DU500_RS17120	COG1401	restriction endodeoxyribonuclease activity
DU500_RS17145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DU500_RS17405	COG0490	domain, Protein
DU500_RS17410	COG0475	glutathione-regulated potassium exporter activity
DU500_RS17460	COG0531	amino acid
DU500_RS17665	COG1192	Involved in chromosome partitioning
DU500_RS17680	COG0589	response to stress
DU500_RS17700	COG1253	flavin adenine dinucleotide binding
DU500_RS17825	COG2337	Toxic component of a toxin-antitoxin (TA) module
DU500_RS17840	COG1028	Short-chain dehydrogenase reductase Sdr
DU500_RS17845	COG1278	Cold shock
DU500_RS17950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins