locus-tag	class	description
HLAC_RS00020	COG1739	Uncharacterized protein family UPF0029
HLAC_RS00040	COG0702	epimerase
HLAC_RS00065	COG0113	porphobilinogen synthase activity
HLAC_RS00085	COG0167	dihydroorotate dehydrogenase activity
HLAC_RS00140	COG0346	lactoylglutathione lyase activity
HLAC_RS00150	COG2719	SpoVR family
HLAC_RS00155	COG2718	Belongs to the UPF0229 family
HLAC_RS00165	COG2766	serine protein kinase
HLAC_RS00215	COG1940	carbohydrate kinase activity
HLAC_RS00240	COG1278	Cold shock
HLAC_RS00260	COG0483	inositol monophosphate 1-phosphatase activity
HLAC_RS00305	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HLAC_RS00315	COG0402	S-adenosylhomocysteine deaminase activity
HLAC_RS00335	COG4608	Belongs to the ABC transporter superfamily
HLAC_RS00340	COG0444	Belongs to the ABC transporter superfamily
HLAC_RS00345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLAC_RS00365	COG0798	PFAM Bile acid sodium symporter
HLAC_RS00390	COG1234	tRNA 3'-trailer cleavage
HLAC_RS00400	COG1132	(ABC) transporter
HLAC_RS00420	COG0656	L-ascorbic acid biosynthetic process
HLAC_RS00440	COG1522	sequence-specific DNA binding
HLAC_RS00450	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HLAC_RS00490	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HLAC_RS00495	COG1301	dicarboxylic acid transport
HLAC_RS00500	COG0049	tRNA binding
HLAC_RS00520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HLAC_RS00525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HLAC_RS00530	COG0085	RNA polymerase activity
HLAC_RS00535	COG0085	RNA polymerase activity
HLAC_RS00575	COG0569	domain protein
HLAC_RS00605	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HLAC_RS00670	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HLAC_RS00720	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLAC_RS00730	COG2608	mercury ion transmembrane transporter activity
HLAC_RS00735	COG1522	sequence-specific DNA binding
HLAC_RS00765	COG0800	Aldolase
HLAC_RS00770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HLAC_RS00785	COG0460	homoserine dehydrogenase
HLAC_RS00790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HLAC_RS00795	COG0051	transcription antitermination factor activity, RNA binding
HLAC_RS00820	COG1840	ABC-type Fe3 transport system, periplasmic component
HLAC_RS00845	COG1178	ABC-type Fe3 transport system permease component
HLAC_RS00855	COG0018	arginyl-trna synthetase
HLAC_RS00880	COG0719	Fe-S assembly protein
HLAC_RS00885	COG0719	Fe-S assembly protein
HLAC_RS00890	COG0396	ATPase activity
HLAC_RS00910	COG0419	ATPase involved in DNA repair
HLAC_RS00915	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HLAC_RS00930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLAC_RS00940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLAC_RS00990	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HLAC_RS01000	COG0307	riboflavin synthase, alpha
HLAC_RS01010	COG0006	proline dipeptidase activity
HLAC_RS01015	COG0210	DNA helicase
HLAC_RS01035	COG1620	l-lactate permease
HLAC_RS01045	COG0277	FAD linked oxidase domain protein
HLAC_RS01050	COG0346	lactoylglutathione lyase activity
HLAC_RS01070	COG1063	alcohol dehydrogenase
HLAC_RS01075	COG1301	dicarboxylic acid transport
HLAC_RS01115	COG0318	PFAM AMP-dependent synthetase and ligase
HLAC_RS01145	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HLAC_RS01160	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HLAC_RS01165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HLAC_RS01170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HLAC_RS01185	COG1492	cobalamin metabolic process
HLAC_RS01200	COG0142	geranyltranstransferase activity
HLAC_RS01215	COG0747	negative chemotaxis
HLAC_RS01220	COG0601	transmembrane transport
HLAC_RS01225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLAC_RS01240	COG0444	Belongs to the ABC transporter superfamily
HLAC_RS01245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLAC_RS01250	COG0601	transmembrane transport
HLAC_RS01265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HLAC_RS01270	COG2252	PERMEase
HLAC_RS01290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLAC_RS01320	COG1201	RNA secondary structure unwinding
HLAC_RS01345	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLAC_RS01360	COG2894	cell division
HLAC_RS01370	COG1269	ATP hydrolysis coupled proton transport
HLAC_RS01395	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HLAC_RS01410	COG0730	response to heat
HLAC_RS01425	COG0415	Belongs to the DNA photolyase family
HLAC_RS01430	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLAC_RS01440	COG0215	cysteine-tRNA ligase activity
HLAC_RS01450	COG0423	glycine-tRNA ligase activity
HLAC_RS01465	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HLAC_RS01495	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HLAC_RS01555	COG0857	belongs to the CobB CobQ family
HLAC_RS01595	COG1227	inorganic diphosphatase activity
HLAC_RS01600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HLAC_RS01605	COG1131	(ABC) transporter
HLAC_RS01620	COG0306	phosphate transporter
HLAC_RS01625	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HLAC_RS01670	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HLAC_RS01675	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HLAC_RS01705	COG0071	Belongs to the small heat shock protein (HSP20) family
HLAC_RS01720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLAC_RS01730	COG0506	proline dehydrogenase activity
HLAC_RS01745	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLAC_RS01745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLAC_RS01770	COG0557	exoribonuclease II activity
HLAC_RS01785	COG0490	domain, Protein
HLAC_RS01790	COG0475	glutathione-regulated potassium exporter activity
HLAC_RS01815	COG0495	leucyl-tRNA aminoacylation
HLAC_RS01835	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HLAC_RS01845	COG3118	belongs to the thioredoxin family
HLAC_RS01850	COG0667	Aldo Keto reductase
HLAC_RS01855	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HLAC_RS01860	COG3639	organic phosphonate transmembrane transporter activity
HLAC_RS01865	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HLAC_RS01875	COG1573	uracil-dna glycosylase
HLAC_RS01895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLAC_RS01900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HLAC_RS01945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLAC_RS01965	COG1121	(ABC) transporter
HLAC_RS01990	COG0714	Associated with various cellular activities
HLAC_RS02065	COG0459	protein refolding
HLAC_RS02080	COG0251	oxidation-reduction process
HLAC_RS02090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLAC_RS02095	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HLAC_RS02100	COG2855	membrane
HLAC_RS02110	COG1078	dGTPase activity
HLAC_RS02125	COG0579	oxidoreductase
HLAC_RS02135	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HLAC_RS02140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLAC_RS02155	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HLAC_RS02195	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HLAC_RS02195	COG1796	DNA polymerase
HLAC_RS02210	COG0717	Belongs to the dCTP deaminase family
HLAC_RS02220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLAC_RS02220	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLAC_RS02255	COG0616	signal peptide processing
HLAC_RS02265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HLAC_RS02280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HLAC_RS02285	COG0512	Glutamine amidotransferase of anthranilate synthase
HLAC_RS02330	COG2205	protein histidine kinase activity
HLAC_RS02340	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HLAC_RS02390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLAC_RS02400	COG2111	Na H antiporter
HLAC_RS02400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLAC_RS02405	COG2111	Na H antiporter
HLAC_RS02410	COG1006	Multisubunit Na H antiporter MnhC subunit
HLAC_RS02415	COG0651	ATP synthesis coupled electron transport
HLAC_RS02420	COG1863	multisubunit Na H antiporter MnhE subunit
HLAC_RS02425	COG2212	antiporter activity
HLAC_RS02430	COG1320	monovalent cation:proton antiporter activity
HLAC_RS02475	COG1268	BioY protein
HLAC_RS02480	COG1122	ATPase activity
HLAC_RS02485	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HLAC_RS02490	COG0247	lactate metabolic process
HLAC_RS02490	COG2181	nitrate reductase activity
HLAC_RS02495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLAC_RS02500	COG0573	inorganic phosphate transmembrane transporter activity
HLAC_RS02505	COG0581	inorganic phosphate transmembrane transporter activity
HLAC_RS02510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLAC_RS02525	COG0574	Belongs to the PEP-utilizing enzyme family
HLAC_RS02525	COG3848	Pyruvate phosphate dikinase
HLAC_RS02530	COG2514	catechol 2,3-dioxygenase activity
HLAC_RS02535	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HLAC_RS02535	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HLAC_RS02540	COG1703	isobutyryl-CoA mutase activity
HLAC_RS02545	COG0596	Alpha beta hydrolase
HLAC_RS02555	COG0037	tRNA processing
HLAC_RS02565	COG0297	glycogen (starch) synthase activity
HLAC_RS02580	COG0656	L-ascorbic acid biosynthetic process
HLAC_RS02595	COG1063	alcohol dehydrogenase
HLAC_RS02600	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HLAC_RS02620	COG1196	nuclear chromosome segregation
HLAC_RS02630	COG2226	methyltransferase
HLAC_RS02640	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HLAC_RS02645	COG0095	Lipoate-protein ligase
HLAC_RS02660	COG0783	Belongs to the Dps family
HLAC_RS02670	COG3634	alkyl hydroperoxide reductase activity
HLAC_RS02675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLAC_RS02680	COG1120	ATPase activity
HLAC_RS02690	COG3634	alkyl hydroperoxide reductase activity
HLAC_RS02700	COG0366	Alpha amylase catalytic
HLAC_RS02715	COG0107	imidazoleglycerol-phosphate synthase activity
HLAC_RS02720	COG1216	Glycosyl transferase, family 2
HLAC_RS02750	COG2124	cytochrome p450
HLAC_RS02760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLAC_RS02830	COG0589	response to stress
HLAC_RS02835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HLAC_RS02835	COG0519	Catalyzes the synthesis of GMP from XMP
HLAC_RS02840	COG0585	pseudouridine synthase activity
HLAC_RS02870	COG0656	L-ascorbic acid biosynthetic process
HLAC_RS02880	COG1505	serine-type exopeptidase activity
HLAC_RS02895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HLAC_RS02900	COG0714	Associated with various cellular activities
HLAC_RS02920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLAC_RS02960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLAC_RS02960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLAC_RS02970	COG1515	deoxyribonuclease V activity
HLAC_RS02980	COG0710	3-dehydroquinate dehydratase activity
HLAC_RS02995	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HLAC_RS03010	COG0330	HflC and HflK could
HLAC_RS03020	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HLAC_RS03035	COG0587	DNA-directed DNA polymerase activity
HLAC_RS03120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HLAC_RS03130	COG3833	ABC-type maltose transport systems, permease component
HLAC_RS03135	COG1175	transmembrane transport
HLAC_RS03145	COG3842	ATPase activity
HLAC_RS03150	COG0435	Glutathione S-transferase
HLAC_RS03215	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HLAC_RS03240	COG2234	aminopeptidase activity
HLAC_RS03250	COG1454	alcohol dehydrogenase
HLAC_RS03250	COG1012	belongs to the aldehyde dehydrogenase family
HLAC_RS03280	COG0003	Pfam Anion-transporting ATPase
HLAC_RS03305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLAC_RS03310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HLAC_RS03320	COG0019	diaminopimelate decarboxylase activity
HLAC_RS03325	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HLAC_RS03340	COG0747	negative chemotaxis
HLAC_RS03345	COG0601	transmembrane transport
HLAC_RS03350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLAC_RS03360	COG4608	Belongs to the ABC transporter superfamily
HLAC_RS03375	COG0484	heat shock protein binding
HLAC_RS03380	COG0443	Heat shock 70 kDa protein
HLAC_RS03395	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HLAC_RS03405	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HLAC_RS03440	COG2201	protein-glutamate methylesterase activity
HLAC_RS03450	COG0463	Glycosyl transferase, family 2
HLAC_RS03470	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HLAC_RS03485	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HLAC_RS03490	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLAC_RS03495	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLAC_RS03500	COG0649	NAD binding
HLAC_RS03510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLAC_RS03515	COG0839	Belongs to the complex I subunit 6 family
HLAC_RS03525	COG0713	ATP synthesis coupled electron transport
HLAC_RS03535	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLAC_RS03540	COG1007	ATP synthesis coupled electron transport
HLAC_RS03560	COG3852	Histidine kinase
HLAC_RS03565	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLAC_RS03575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HLAC_RS03575	COG0519	Catalyzes the synthesis of GMP from XMP
HLAC_RS03585	COG0372	Belongs to the citrate synthase family
HLAC_RS03590	COG1363	Peptidase, m42
HLAC_RS03600	COG0484	heat shock protein binding
HLAC_RS03620	COG1063	alcohol dehydrogenase
HLAC_RS03635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HLAC_RS03845	COG0442	prolyl-tRNA aminoacylation
HLAC_RS03850	COG0494	nUDIX hydrolase
HLAC_RS03870	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HLAC_RS03885	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HLAC_RS03890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HLAC_RS03950	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HLAC_RS03955	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HLAC_RS03970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLAC_RS03975	COG2301	Belongs to the HpcH HpaI aldolase family
HLAC_RS03990	COG1047	Peptidyl-prolyl cis-trans
HLAC_RS04010	COG3679	Belongs to the UPF0342 family
HLAC_RS04060	COG0318	PFAM AMP-dependent synthetase and ligase
HLAC_RS04065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HLAC_RS04105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLAC_RS04115	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HLAC_RS04120	COG0436	Aminotransferase
HLAC_RS04125	COG0589	response to stress
HLAC_RS04130	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLAC_RS04135	COG0154	amidase activity
HLAC_RS04145	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HLAC_RS04150	COG1863	multisubunit Na H antiporter MnhE subunit
HLAC_RS04155	COG2212	antiporter activity
HLAC_RS04160	COG1320	monovalent cation:proton antiporter activity
HLAC_RS04175	COG1006	Multisubunit Na H antiporter MnhC subunit
HLAC_RS04180	COG0651	ATP synthesis coupled electron transport
HLAC_RS04185	COG0651	ATP synthesis coupled electron transport
HLAC_RS04190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLAC_RS04190	COG2111	Na H antiporter
HLAC_RS04220	COG1121	(ABC) transporter
HLAC_RS04270	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HLAC_RS04280	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLAC_RS04305	COG0473	3-isopropylmalate dehydrogenase activity
HLAC_RS04310	COG0066	3-isopropylmalate dehydratase activity
HLAC_RS04315	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HLAC_RS04320	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HLAC_RS04330	COG0028	Belongs to the TPP enzyme family
HLAC_RS04335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLAC_RS04345	COG1793	dna ligase
HLAC_RS04350	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HLAC_RS04360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLAC_RS04365	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HLAC_RS04380	COG0667	Aldo Keto reductase
HLAC_RS04390	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HLAC_RS04400	COG1522	sequence-specific DNA binding
HLAC_RS04405	COG1013	pyruvate-flavodoxin oxidoreductase activity
HLAC_RS04420	COG1125	glycine betaine transport
HLAC_RS04420	COG0517	IMP dehydrogenase activity
HLAC_RS04435	COG1285	pathogenesis
HLAC_RS04455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HLAC_RS04475	COG0384	phenazine biosynthesis protein PhzF
HLAC_RS04510	COG0070	glutamate synthase
HLAC_RS04510	COG0067	glutamate synthase
HLAC_RS04510	COG0069	glutamate synthase activity
HLAC_RS04515	COG1132	(ABC) transporter
HLAC_RS04560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HLAC_RS04565	COG0138	bifunctional purine biosynthesis protein purh
HLAC_RS04575	COG1013	pyruvate-flavodoxin oxidoreductase activity
HLAC_RS04580	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HLAC_RS04580	COG0674	pyruvate-flavodoxin oxidoreductase activity
HLAC_RS04590	COG0436	Aminotransferase
HLAC_RS04635	COG0295	cytidine deaminase activity
HLAC_RS04640	COG0628	permease
HLAC_RS04650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HLAC_RS04680	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLAC_RS04690	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HLAC_RS04700	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HLAC_RS04710	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HLAC_RS04745	COG2890	protein-(glutamine-N5) methyltransferase activity
HLAC_RS04760	COG0300	oxidoreductase activity
HLAC_RS04770	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HLAC_RS04775	COG1803	Methylglyoxal synthase
HLAC_RS04795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLAC_RS04830	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HLAC_RS04835	COG2076	Multidrug Resistance protein
HLAC_RS04875	COG1511	domain protein
HLAC_RS04875	COG3264	Mechanosensitive ion channel
HLAC_RS04885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HLAC_RS04895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLAC_RS04910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLAC_RS04915	COG0187	DNA topoisomerase II activity
HLAC_RS04970	COG0183	Belongs to the thiolase family
HLAC_RS04985	COG1185	polyribonucleotide nucleotidyltransferase activity
HLAC_RS05000	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HLAC_RS05005	COG0346	lactoylglutathione lyase activity
HLAC_RS05010	COG2116	formate transmembrane transporter activity
HLAC_RS05015	COG0393	Putative heavy-metal-binding
HLAC_RS05020	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HLAC_RS05020	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HLAC_RS05030	COG1011	Hydrolase
HLAC_RS05050	COG1028	Short-chain dehydrogenase reductase Sdr
HLAC_RS05095	COG4106	trans-aconitate 2-methyltransferase activity
HLAC_RS05105	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HLAC_RS05130	COG0470	DNA polymerase III
HLAC_RS05130	COG1067	ATP-dependent peptidase activity
HLAC_RS05160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HLAC_RS05180	COG0431	NADPH-dependent FMN reductase
HLAC_RS05190	COG2132	Multicopper oxidase
HLAC_RS05200	COG0006	proline dipeptidase activity
HLAC_RS05210	COG1473	amidohydrolase
HLAC_RS05220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLAC_RS05230	COG1473	amidohydrolase
HLAC_RS05235	COG2130	NADP-dependent
HLAC_RS05260	COG1215	transferase activity, transferring glycosyl groups
HLAC_RS05280	COG0438	transferase activity, transferring glycosyl groups
HLAC_RS05325	COG1378	Sugar-specific transcriptional regulator TrmB
HLAC_RS05335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HLAC_RS05360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLAC_RS05410	COG1028	Short-chain dehydrogenase reductase Sdr
HLAC_RS05415	COG0431	NADPH-dependent FMN reductase
HLAC_RS05415	COG1053	succinate dehydrogenase
HLAC_RS05415	COG3976	FMN-binding domain protein
HLAC_RS05430	COG1335	isochorismatase
HLAC_RS05440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLAC_RS05445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLAC_RS05450	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HLAC_RS05455	COG0066	3-isopropylmalate dehydratase activity
HLAC_RS05465	COG3268	Saccharopine dehydrogenase
HLAC_RS05490	COG0501	Belongs to the peptidase M48B family
HLAC_RS05510	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HLAC_RS05525	COG1024	Enoyl-CoA hydratase
HLAC_RS05530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HLAC_RS05550	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HLAC_RS05555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HLAC_RS05565	COG0247	lactate metabolic process
HLAC_RS05650	COG1960	acyl-CoA dehydrogenase activity
HLAC_RS05685	COG0559	Belongs to the binding-protein-dependent transport system permease family
HLAC_RS05695	COG0506	proline dehydrogenase activity
HLAC_RS05705	COG1012	belongs to the aldehyde dehydrogenase family
HLAC_RS05820	COG1575	Belongs to the MenA family. Type 1 subfamily
HLAC_RS05840	COG1522	sequence-specific DNA binding
HLAC_RS05855	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HLAC_RS05855	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HLAC_RS05865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLAC_RS05870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLAC_RS05875	COG0569	domain protein
HLAC_RS05880	COG0668	transmembrane transport
HLAC_RS05905	COG1121	(ABC) transporter
HLAC_RS05910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLAC_RS05945	COG3361	conserved protein (COG2071)
HLAC_RS05950	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLAC_RS05970	COG1960	acyl-CoA dehydrogenase activity
HLAC_RS05975	COG1562	ergosterol biosynthetic process
HLAC_RS05980	COG4581	dead DEAH box helicase
HLAC_RS05985	COG2204	response regulator
HLAC_RS05990	COG0516	GMP reductase activity
HLAC_RS05990	COG0517	IMP dehydrogenase activity
HLAC_RS06015	COG0535	radical SAM domain protein
HLAC_RS06020	COG4974	Belongs to the 'phage' integrase family
HLAC_RS06045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLAC_RS06075	COG3842	ATPase activity
HLAC_RS06080	COG0438	transferase activity, transferring glycosyl groups
HLAC_RS06095	COG4191	Histidine kinase
HLAC_RS06120	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HLAC_RS06120	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HLAC_RS06125	COG0315	cyclic pyranopterin monophosphate synthase activity
HLAC_RS06130	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HLAC_RS06135	COG3383	formate dehydrogenase (NAD+) activity
HLAC_RS06145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HLAC_RS06175	COG2226	methyltransferase
HLAC_RS06180	COG0129	dihydroxy-acid dehydratase activity
HLAC_RS06190	COG0047	phosphoribosylformylglycinamidine synthase activity
HLAC_RS06200	COG0788	formyltetrahydrofolate deformylase activity
HLAC_RS06210	COG1201	RNA secondary structure unwinding
HLAC_RS06250	COG2391	methyltransferase activity
HLAC_RS06265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLAC_RS06275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLAC_RS06280	COG0531	amino acid
HLAC_RS06305	COG0134	indole-3-glycerol-phosphate synthase activity
HLAC_RS06310	COG0133	tryptophan synthase activity
HLAC_RS06315	COG0159	tryptophan synthase activity
HLAC_RS06320	COG1830	Aldolase
HLAC_RS06335	COG1465	3-dehydroquinate synthase
HLAC_RS06360	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HLAC_RS06365	COG0540	Belongs to the ATCase OTCase family
HLAC_RS06390	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HLAC_RS06395	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HLAC_RS06400	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HLAC_RS06410	COG0110	maltose O-acetyltransferase activity
HLAC_RS06415	COG0151	Belongs to the GarS family
HLAC_RS06420	COG1331	Highly conserved protein containing a thioredoxin domain
HLAC_RS06440	COG4948	Mandelate Racemase Muconate Lactonizing
HLAC_RS06455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLAC_RS06460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLAC_RS06470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLAC_RS06480	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLAC_RS06500	COG1278	Cold shock
HLAC_RS06525	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLAC_RS06535	COG0436	Aminotransferase
HLAC_RS06545	COG0667	Aldo Keto reductase
HLAC_RS06555	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HLAC_RS06605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HLAC_RS06615	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HLAC_RS06620	COG1140	nitrate reductase beta subunit
HLAC_RS06645	COG0489	protein tyrosine kinase activity
HLAC_RS06660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HLAC_RS06665	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLAC_RS06675	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HLAC_RS06685	COG3852	Histidine kinase
HLAC_RS06720	COG2814	Major facilitator Superfamily
HLAC_RS06785	COG4347	Protein of unknown function (DUF1405)
HLAC_RS06805	COG2414	aldehyde ferredoxin oxidoreductase
HLAC_RS06835	COG1757	Na H antiporter
HLAC_RS06840	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HLAC_RS06915	COG0436	Aminotransferase
HLAC_RS06920	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
HLAC_RS06950	COG0247	lactate metabolic process
HLAC_RS06950	COG0277	FAD linked oxidase domain protein
HLAC_RS06960	COG0494	nUDIX hydrolase
HLAC_RS06975	COG0243	molybdopterin cofactor binding
HLAC_RS06980	COG0243	molybdopterin cofactor binding
HLAC_RS06985	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLAC_RS07000	COG1473	amidohydrolase
HLAC_RS07010	COG0445	tRNA wobble uridine modification
HLAC_RS07015	COG1079	Belongs to the binding-protein-dependent transport system permease family
HLAC_RS07020	COG4603	Belongs to the binding-protein-dependent transport system permease family
HLAC_RS07025	COG3845	ABC transporter
HLAC_RS07030	COG1744	ABC transporter substrate-binding protein PnrA-like
HLAC_RS07035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLAC_RS07040	COG1254	Belongs to the acylphosphatase family
HLAC_RS07060	COG0346	lactoylglutathione lyase activity
HLAC_RS07080	COG1131	(ABC) transporter
HLAC_RS07125	COG0415	Belongs to the DNA photolyase family
HLAC_RS07130	COG1111	helicase
HLAC_RS07130	COG1205	dead DEAH box helicase
HLAC_RS07170	COG3546	catalase activity
HLAC_RS07205	COG1215	transferase activity, transferring glycosyl groups
HLAC_RS07215	COG2376	Dihydroxyacetone kinase
HLAC_RS07220	COG1461	Dihydroxyacetone kinase
HLAC_RS07235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLAC_RS07250	COG0012	GTP binding
HLAC_RS07260	COG0589	response to stress
HLAC_RS07265	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HLAC_RS07265	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HLAC_RS07285	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLAC_RS07315	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HLAC_RS07350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HLAC_RS07350	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HLAC_RS07385	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HLAC_RS07400	COG0589	response to stress
HLAC_RS07405	COG0318	PFAM AMP-dependent synthetase and ligase
HLAC_RS07410	COG1960	acyl-CoA dehydrogenase activity
HLAC_RS07425	COG1193	negative regulation of DNA recombination
HLAC_RS07560	COG0280	phosphate acetyltransferase
HLAC_RS07560	COG0281	malic enzyme
HLAC_RS07580	COG0534	Mate efflux family protein
HLAC_RS07585	COG0668	transmembrane transport
HLAC_RS07600	COG0667	Aldo Keto reductase
HLAC_RS07615	COG0028	Belongs to the TPP enzyme family
HLAC_RS07620	COG0673	inositol 2-dehydrogenase activity
HLAC_RS07625	COG2311	Membrane
HLAC_RS07670	COG0626	cystathionine gamma-synthase activity
HLAC_RS07680	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HLAC_RS07700	COG2346	COG2346, Truncated hemoglobins
HLAC_RS07715	COG0657	acetylesterase activity
HLAC_RS07725	COG0572	uridine kinase
HLAC_RS07745	COG0673	inositol 2-dehydrogenase activity
HLAC_RS07750	COG0656	L-ascorbic acid biosynthetic process
HLAC_RS07760	COG1546	Belongs to the CinA family
HLAC_RS07760	COG1058	Belongs to the CinA family
HLAC_RS07765	COG2226	methyltransferase
HLAC_RS07780	COG1435	thymidine kinase activity
HLAC_RS07785	COG0402	S-adenosylhomocysteine deaminase activity
HLAC_RS07790	COG1078	dGTPase activity
HLAC_RS07830	COG0010	Belongs to the arginase family
HLAC_RS07875	COG0284	orotidine-5'-phosphate decarboxylase activity
HLAC_RS07920	COG0398	Pfam SNARE associated Golgi protein
HLAC_RS07930	COG3119	arylsulfatase activity
HLAC_RS07935	COG0596	Alpha beta hydrolase
HLAC_RS07970	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HLAC_RS07995	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HLAC_RS08000	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HLAC_RS08005	COG0509	glycine decarboxylation via glycine cleavage system
HLAC_RS08015	COG0668	transmembrane transport
HLAC_RS08040	COG0673	inositol 2-dehydrogenase activity
HLAC_RS08045	COG1082	Xylose isomerase domain protein TIM barrel
HLAC_RS08055	COG4948	Mandelate Racemase Muconate Lactonizing
HLAC_RS08065	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HLAC_RS08070	COG0656	L-ascorbic acid biosynthetic process
HLAC_RS08080	COG0517	IMP dehydrogenase activity
HLAC_RS08085	COG1404	Belongs to the peptidase S8 family
HLAC_RS08095	COG1278	Cold shock
HLAC_RS08130	COG0733	neurotransmitter:sodium symporter activity
HLAC_RS08135	COG0644	oxidoreductase
HLAC_RS08180	COG2154	pterin-4-alpha-carbinolamine dehydratase
HLAC_RS08215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HLAC_RS08225	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HLAC_RS08235	COG0017	Asparaginyl-tRNA synthetase
HLAC_RS08255	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HLAC_RS08280	COG0101	tRNA pseudouridine synthase activity
HLAC_RS08315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HLAC_RS08335	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HLAC_RS08350	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HLAC_RS08350	COG0778	Nitroreductase
HLAC_RS08355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLAC_RS08390	COG2897	thiosulfate sulfurtransferase activity
HLAC_RS08420	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
HLAC_RS08465	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HLAC_RS08480	COG0589	response to stress
HLAC_RS08505	COG1546	Belongs to the CinA family
HLAC_RS08505	COG1058	Belongs to the CinA family
HLAC_RS08520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLAC_RS08535	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLAC_RS08540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HLAC_RS08645	COG0492	ferredoxin-NADP+ reductase activity
HLAC_RS08655	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLAC_RS08670	COG1757	Na H antiporter
HLAC_RS08695	COG2217	Heavy metal translocating P-type atpase
HLAC_RS08750	COG1832	CoA-binding protein
HLAC_RS08755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLAC_RS08765	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HLAC_RS08770	COG0517	IMP dehydrogenase activity
HLAC_RS08770	COG0516	GMP reductase activity
HLAC_RS08815	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HLAC_RS08850	COG2135	peptidase activity
HLAC_RS08880	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HLAC_RS08890	COG0730	response to heat
HLAC_RS08895	COG0483	inositol monophosphate 1-phosphatase activity
HLAC_RS08905	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLAC_RS08925	COG2205	protein histidine kinase activity
HLAC_RS08930	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HLAC_RS08955	COG0765	amino acid transport
HLAC_RS08995	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HLAC_RS09010	COG0604	alcohol dehydrogenase
HLAC_RS09020	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HLAC_RS09025	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HLAC_RS09030	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HLAC_RS09055	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HLAC_RS09075	COG0052	Belongs to the universal ribosomal protein uS2 family
HLAC_RS09090	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HLAC_RS09100	COG0489	protein tyrosine kinase activity
HLAC_RS09115	COG0523	cobalamin synthesis protein
HLAC_RS09130	COG1063	alcohol dehydrogenase
HLAC_RS09170	COG0105	UTP biosynthetic process
HLAC_RS09195	COG0183	Belongs to the thiolase family
HLAC_RS09200	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HLAC_RS09215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLAC_RS09290	COG2217	Heavy metal translocating P-type atpase
HLAC_RS09320	COG1605	Chorismate mutase
HLAC_RS09320	COG0287	Prephenate dehydrogenase
HLAC_RS09390	COG1253	flavin adenine dinucleotide binding
HLAC_RS09410	COG1920	GTP binding
HLAC_RS09415	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HLAC_RS09420	COG0668	transmembrane transport
HLAC_RS09425	COG1028	Short-chain dehydrogenase reductase Sdr
HLAC_RS09430	COG1233	COG1233 Phytoene dehydrogenase and related
HLAC_RS09470	COG0531	amino acid
HLAC_RS09505	COG0563	adenylate kinase activity
HLAC_RS09520	COG0657	acetylesterase activity
HLAC_RS09530	COG0596	Alpha beta hydrolase
HLAC_RS09545	COG1028	Short-chain dehydrogenase reductase Sdr
HLAC_RS09555	COG1546	Belongs to the CinA family
HLAC_RS09555	COG1058	Belongs to the CinA family
HLAC_RS09640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HLAC_RS09645	COG0135	phosphoribosylanthranilate isomerase activity
HLAC_RS09650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HLAC_RS09655	COG0512	Glutamine amidotransferase of anthranilate synthase
HLAC_RS09655	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HLAC_RS09660	COG0521	Mo-molybdopterin cofactor biosynthetic process
HLAC_RS09695	COG0628	permease
HLAC_RS09710	COG2226	methyltransferase
HLAC_RS09715	COG2897	thiosulfate sulfurtransferase activity
HLAC_RS09735	COG0464	growth
HLAC_RS09740	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HLAC_RS09760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLAC_RS09760	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLAC_RS09765	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLAC_RS09775	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HLAC_RS09860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HLAC_RS09890	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HLAC_RS09895	COG1053	succinate dehydrogenase
HLAC_RS09910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HLAC_RS09970	COG0667	Aldo Keto reductase
HLAC_RS09985	COG2988	succinylglutamate desuccinylase activity
HLAC_RS10000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLAC_RS10005	COG0745	RESPONSE REGULATOR receiver
HLAC_RS10015	COG2309	aminopeptidase activity
HLAC_RS10020	COG0501	Belongs to the peptidase M48B family
HLAC_RS10035	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HLAC_RS10115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HLAC_RS10165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLAC_RS10180	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLAC_RS10185	COG0142	geranyltranstransferase activity
HLAC_RS10190	COG0697	spore germination
HLAC_RS10200	COG4191	Histidine kinase
HLAC_RS10205	COG0024	Methionine aminopeptidase
HLAC_RS10220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLAC_RS10245	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HLAC_RS10260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HLAC_RS10280	COG0864	Transcriptional regulator
HLAC_RS10290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLAC_RS10305	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HLAC_RS10310	COG5487	UPF0391 membrane protein
HLAC_RS10325	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HLAC_RS10335	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HLAC_RS10345	COG0535	radical SAM domain protein
HLAC_RS10440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HLAC_RS10445	COG0534	Mate efflux family protein
HLAC_RS10450	COG1335	isochorismatase
HLAC_RS10465	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HLAC_RS10470	COG0668	transmembrane transport
HLAC_RS10485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HLAC_RS10510	COG1902	pentaerythritol trinitrate reductase activity
HLAC_RS10520	COG0434	BtpA family
HLAC_RS10525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLAC_RS10530	COG0590	tRNA wobble adenosine to inosine editing
HLAC_RS10555	COG0303	'Molybdopterin
HLAC_RS10560	COG0303	'Molybdopterin
HLAC_RS10575	COG5002	protein histidine kinase activity
HLAC_RS10600	COG1648	precorrin-2 dehydrogenase activity
HLAC_RS10600	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HLAC_RS10605	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HLAC_RS10620	COG0358	DNA primase activity
HLAC_RS10645	COG0252	asparaginase activity
HLAC_RS10675	COG0589	response to stress
HLAC_RS10695	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HLAC_RS10700	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HLAC_RS10715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLAC_RS10755	COG0589	response to stress
HLAC_RS10765	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HLAC_RS10770	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HLAC_RS10780	COG0577	efflux transmembrane transporter activity
HLAC_RS10780	COG1136	(ABC) transporter
HLAC_RS10820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HLAC_RS10825	COG0110	maltose O-acetyltransferase activity
HLAC_RS10845	COG0456	acetyltransferase
HLAC_RS10855	COG0647	UMP catabolic process
HLAC_RS10875	COG1695	Transcriptional regulator
HLAC_RS10885	COG3253	May function as heme-dependent peroxidase
HLAC_RS10920	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLAC_RS10925	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HLAC_RS10930	COG0402	S-adenosylhomocysteine deaminase activity
HLAC_RS10940	COG0271	Belongs to the BolA IbaG family
HLAC_RS10950	COG0114	fumarate hydratase activity
HLAC_RS10965	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HLAC_RS10975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLAC_RS10985	COG1022	Amp-dependent synthetase and ligase
HLAC_RS11015	COG2193	ferroxidase activity
HLAC_RS11035	COG0693	protein deglycase activity
HLAC_RS11040	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HLAC_RS11055	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HLAC_RS11060	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HLAC_RS11090	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HLAC_RS11090	COG0617	tRNA 3'-terminal CCA addition
HLAC_RS11090	COG0517	IMP dehydrogenase activity
HLAC_RS11100	COG1363	Peptidase, m42
HLAC_RS11115	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HLAC_RS11120	COG1414	Transcriptional regulator
HLAC_RS11125	COG1312	Catalyzes the dehydration of D-mannonate
HLAC_RS11130	COG1012	belongs to the aldehyde dehydrogenase family
HLAC_RS11135	COG0673	inositol 2-dehydrogenase activity
HLAC_RS11140	COG4948	Mandelate Racemase Muconate Lactonizing
HLAC_RS11165	COG0822	iron-sulfur transferase activity
HLAC_RS11170	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HLAC_RS11190	COG0181	hydroxymethylbilane synthase activity
HLAC_RS11195	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HLAC_RS11195	COG1648	precorrin-2 dehydrogenase activity
HLAC_RS11210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLAC_RS11235	COG0784	Response regulator, receiver
HLAC_RS11235	COG0835	chemotaxis
HLAC_RS11240	COG2201	protein-glutamate methylesterase activity
HLAC_RS11245	COG0643	Histidine kinase
HLAC_RS11245	COG2198	Histidine kinase
HLAC_RS11250	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HLAC_RS11275	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HLAC_RS11290	COG0252	asparaginase activity
HLAC_RS11305	COG1378	Sugar-specific transcriptional regulator TrmB
HLAC_RS11345	COG0667	Aldo Keto reductase
HLAC_RS11365	COG0166	Belongs to the GPI family
HLAC_RS11395	COG0667	Aldo Keto reductase
HLAC_RS11405	COG0475	glutathione-regulated potassium exporter activity
HLAC_RS11410	COG1757	Na H antiporter
HLAC_RS11415	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HLAC_RS11425	COG2116	formate transmembrane transporter activity
HLAC_RS11440	COG0083	homoserine kinase activity
HLAC_RS11445	COG2226	methyltransferase
HLAC_RS11445	COG1073	alpha beta
HLAC_RS11455	COG3118	belongs to the thioredoxin family
HLAC_RS11485	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HLAC_RS11530	COG1444	tRNA N-acetyltransferase activity
HLAC_RS11540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLAC_RS11555	COG0505	Belongs to the CarA family
HLAC_RS11575	COG2358	TRAP transporter, solute receptor (TAXI family
HLAC_RS11580	COG0538	isocitrate dehydrogenase activity
HLAC_RS11600	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HLAC_RS11675	COG2096	Adenosyltransferase
HLAC_RS11725	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
HLAC_RS11745	COG0667	Aldo Keto reductase
HLAC_RS11785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HLAC_RS11790	COG0126	phosphoglycerate kinase activity
HLAC_RS11795	COG1522	sequence-specific DNA binding
HLAC_RS11825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLAC_RS11840	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HLAC_RS11855	COG0314	molybdopterin synthase activity
HLAC_RS11860	COG0528	UMP kinase activity
HLAC_RS11875	COG2205	protein histidine kinase activity
HLAC_RS11885	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HLAC_RS11905	COG1185	polyribonucleotide nucleotidyltransferase activity
HLAC_RS11910	COG1671	Belongs to the UPF0178 family
HLAC_RS11950	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HLAC_RS11950	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HLAC_RS11955	COG1612	heme a metabolic process
HLAC_RS11955	COG0109	protoheme IX farnesyltransferase activity
HLAC_RS11985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HLAC_RS12000	COG0425	Belongs to the sulfur carrier protein TusA family
HLAC_RS12000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLAC_RS12020	COG2210	Belongs to the sulfur carrier protein TusA family
HLAC_RS12025	COG0425	Belongs to the sulfur carrier protein TusA family
HLAC_RS12030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLAC_RS12030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLAC_RS12040	COG2391	methyltransferase activity
HLAC_RS12045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLAC_RS12055	COG0200	Binds to the 23S rRNA
HLAC_RS12080	COG0322	excinuclease ABC activity
HLAC_RS12085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HLAC_RS12090	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HLAC_RS12100	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HLAC_RS12115	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HLAC_RS12130	COG0255	Belongs to the universal ribosomal protein uL29 family
HLAC_RS12135	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HLAC_RS12145	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HLAC_RS12150	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HLAC_RS12165	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HLAC_RS12175	COG2133	pyrroloquinoline quinone binding
HLAC_RS12195	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HLAC_RS12215	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HLAC_RS12220	COG1830	Aldolase
HLAC_RS12225	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLAC_RS12240	COG0477	Major facilitator Superfamily
HLAC_RS12250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HLAC_RS12255	COG0494	nUDIX hydrolase
HLAC_RS12305	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HLAC_RS12335	COG0395	ABC-type sugar transport system, permease component
HLAC_RS12365	COG0534	Mate efflux family protein
HLAC_RS12390	COG3360	Dodecin
HLAC_RS12395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLAC_RS12400	COG0309	Hydrogenase expression formation protein (HypE)
HLAC_RS12405	COG1960	acyl-CoA dehydrogenase activity
HLAC_RS12420	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HLAC_RS12430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HLAC_RS12440	COG0189	ligase activity
HLAC_RS12495	COG0688	phosphatidylethanolamine metabolic process
HLAC_RS12500	COG0470	DNA polymerase III
HLAC_RS12510	COG1175	transmembrane transport
HLAC_RS12515	COG0395	ABC-type sugar transport system, permease component
HLAC_RS12520	COG3842	ATPase activity
HLAC_RS12545	COG3422	double-strand break repair
HLAC_RS12585	COG0081	regulation of translation
HLAC_RS12590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HLAC_RS12610	COG0439	Biotin carboxylase
HLAC_RS12640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HLAC_RS12650	COG0318	PFAM AMP-dependent synthetase and ligase
HLAC_RS12655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLAC_RS12660	COG2873	o-acetylhomoserine
HLAC_RS12675	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HLAC_RS12710	COG2201	protein-glutamate methylesterase activity
HLAC_RS12720	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HLAC_RS12780	COG0501	Belongs to the peptidase M48B family
HLAC_RS12790	COG2814	Major facilitator Superfamily
HLAC_RS12795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLAC_RS12805	COG4948	Mandelate Racemase Muconate Lactonizing
HLAC_RS12820	COG1028	Short-chain dehydrogenase reductase Sdr
HLAC_RS12855	COG0427	acetyl-CoA hydrolase
HLAC_RS12860	COG0579	oxidoreductase
HLAC_RS12875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HLAC_RS12875	COG0519	Catalyzes the synthesis of GMP from XMP
HLAC_RS12880	COG0504	CTP synthase activity
HLAC_RS12930	COG1606	tRNA processing
HLAC_RS12935	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HLAC_RS12940	COG0251	oxidation-reduction process
HLAC_RS12945	COG2239	Acts as a magnesium transporter
HLAC_RS12950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HLAC_RS12955	COG0805	protein transport
HLAC_RS12960	COG0805	protein transport
HLAC_RS12965	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HLAC_RS12970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLAC_RS12975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLAC_RS12980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HLAC_RS12985	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HLAC_RS12990	COG0189	ligase activity
HLAC_RS13000	COG0165	Argininosuccinate lyase
HLAC_RS13005	COG0137	argininosuccinate synthase activity
HLAC_RS13020	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HLAC_RS13025	COG0004	ammonium transporteR
HLAC_RS13070	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HLAC_RS13080	COG1691	(AIR) carboxylase
HLAC_RS13085	COG2827	Endonuclease containing a URI domain
HLAC_RS13090	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HLAC_RS13095	COG0556	nucleotide-excision repair
HLAC_RS13115	COG2873	o-acetylhomoserine
HLAC_RS13125	COG1131	(ABC) transporter
HLAC_RS13130	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HLAC_RS13135	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HLAC_RS13150	COG0039	L-malate dehydrogenase activity
HLAC_RS13180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLAC_RS13210	COG0459	protein refolding
HLAC_RS13225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLAC_RS13235	COG2309	aminopeptidase activity
HLAC_RS13240	COG1139	Iron-sulfur cluster binding protein
HLAC_RS13250	COG1620	l-lactate permease
HLAC_RS13255	COG0072	phenylalanine-tRNA ligase activity
HLAC_RS13255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLAC_RS13325	COG4191	Histidine kinase
HLAC_RS13330	COG0456	acetyltransferase
HLAC_RS13335	COG1164	Oligoendopeptidase f
HLAC_RS13340	COG0531	amino acid
HLAC_RS13360	COG0490	domain, Protein
HLAC_RS13370	COG0531	amino acid
HLAC_RS13380	COG3842	ATPase activity
HLAC_RS13385	COG4208	sulfate ABC transporter
HLAC_RS13400	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HLAC_RS13405	COG1902	pentaerythritol trinitrate reductase activity
HLAC_RS13410	COG0131	Imidazoleglycerol-phosphate dehydratase
HLAC_RS13465	COG1966	Carbon starvation protein
HLAC_RS13485	COG0523	cobalamin synthesis protein
HLAC_RS13495	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HLAC_RS13505	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HLAC_RS13510	COG1454	alcohol dehydrogenase
HLAC_RS13520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLAC_RS13535	COG0322	excinuclease ABC activity
HLAC_RS13560	COG0560	Phosphoserine phosphatase
HLAC_RS13590	COG2226	methyltransferase
HLAC_RS13625	COG0527	aspartate kinase activity
HLAC_RS13640	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HLAC_RS13690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLAC_RS13750	COG1401	restriction endodeoxyribonuclease activity
HLAC_RS13780	COG0589	response to stress
HLAC_RS13820	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HLAC_RS14080	COG2217	Heavy metal translocating P-type atpase
HLAC_RS14085	COG2217	Heavy metal translocating P-type atpase
HLAC_RS14095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLAC_RS14115	COG0109	protoheme IX farnesyltransferase activity
HLAC_RS14150	COG1653	transport
HLAC_RS14160	COG0395	ABC-type sugar transport system, permease component
HLAC_RS14165	COG3842	ATPase activity
HLAC_RS14170	COG4948	Mandelate Racemase Muconate Lactonizing
HLAC_RS14175	COG1028	Short-chain dehydrogenase reductase Sdr
HLAC_RS14185	COG3345	alpha-galactosidase
HLAC_RS14275	COG5000	phosphorelay sensor kinase activity
HLAC_RS14430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLAC_RS14440	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HLAC_RS14505	COG0842	Transport permease protein
HLAC_RS14505	COG1129	ABC transporter
HLAC_RS14535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLAC_RS14545	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HLAC_RS14685	COG0435	Glutathione S-transferase
HLAC_RS14690	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HLAC_RS14720	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HLAC_RS14725	COG0351	phosphomethylpyrimidine kinase
HLAC_RS14745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLAC_RS14755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLAC_RS14870	COG0701	Predicted permease
HLAC_RS14905	COG1192	Involved in chromosome partitioning
HLAC_RS14915	COG3794	PFAM blue (type 1) copper domain protein
HLAC_RS14935	COG2132	Multicopper oxidase
HLAC_RS14940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLAC_RS14940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLAC_RS14970	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HLAC_RS15000	COG1012	belongs to the aldehyde dehydrogenase family
HLAC_RS15025	COG2217	Heavy metal translocating P-type atpase
HLAC_RS15045	COG2217	Heavy metal translocating P-type atpase
HLAC_RS15055	COG0602	queuosine metabolic process
HLAC_RS15060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HLAC_RS15105	COG3385	transposase activity
HLAC_RS15145	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HLAC_RS15190	COG0864	Transcriptional regulator
HLAC_RS15210	COG1192	Involved in chromosome partitioning
HLAC_RS15600	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HLAC_RS15610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLAC_RS15665	COG1074	ATP-dependent DNA helicase activity
HLAC_RS15775	COG1074	ATP-dependent DNA helicase activity
HLAC_RS15805	COG1205	dead DEAH box helicase
HLAC_RS15805	COG1111	helicase
HLAC_RS15815	COG0217	transcriptional regulatory protein
HLAC_RS15850	COG1192	Involved in chromosome partitioning
HLAC_RS15855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLAC_RS15925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLAC_RS15930	COG0444	Belongs to the ABC transporter superfamily
HLAC_RS15935	COG4608	Belongs to the ABC transporter superfamily
HLAC_RS15940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HLAC_RS15960	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLAC_RS16005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLAC_RS16135	COG4974	Belongs to the 'phage' integrase family
HLAC_RS16200	COG1518	maintenance of DNA repeat elements
HLAC_RS16305	COG0714	Associated with various cellular activities
HLAC_RS16385	COG1012	belongs to the aldehyde dehydrogenase family
HLAC_RS16405	COG1047	Peptidyl-prolyl cis-trans
HLAC_RS16415	COG1192	Involved in chromosome partitioning
HLAC_RS16640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLAC_RS16680	COG0798	PFAM Bile acid sodium symporter
HLAC_RS16710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLAC_RS16720	COG1733	regulation of RNA biosynthetic process
HLAC_RS16725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLAC_RS16775	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HLAC_RS16805	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HLAC_RS16825	COG1648	precorrin-2 dehydrogenase activity
HLAC_RS16825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HLAC_RS16910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLAC_RS17030	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HLAC_RS17040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLAC_RS17045	COG0589	response to stress
HLAC_RS17075	COG2211	Major facilitator Superfamily
HLAC_RS17080	COG1414	Transcriptional regulator
HLAC_RS17095	COG0436	Aminotransferase
HLAC_RS17100	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HLAC_RS17115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLAC_RS17170	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLAC_RS17175	COG0573	inorganic phosphate transmembrane transporter activity
HLAC_RS17180	COG0581	inorganic phosphate transmembrane transporter activity
HLAC_RS17185	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLAC_RS17190	COG0704	Plays a role in the regulation of phosphate uptake
HLAC_RS17205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLAC_RS17245	COG3385	transposase activity
HLAC_RS17250	COG3385	transposase activity
HLAC_RS17310	COG4974	Belongs to the 'phage' integrase family
HLAC_RS17325	COG3119	arylsulfatase activity
HLAC_RS17340	COG2202	Pas domain
HLAC_RS17340	COG1366	Belongs to the anti-sigma-factor antagonist family
HLAC_RS17370	COG5002	protein histidine kinase activity
HLAC_RS17405	COG2205	protein histidine kinase activity
HLAC_RS17490	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HLAC_RS17575	COG5002	protein histidine kinase activity
HLAC_RS17575	COG5001	Diguanylate cyclase
HLAC_RS17575	COG3447	MASE1 domain protein
HLAC_RS17580	COG3852	Histidine kinase
HLAC_RS17605	COG4191	Histidine kinase
HLAC_RS17610	COG1414	Transcriptional regulator
HLAC_RS17615	COG0747	negative chemotaxis
HLAC_RS17710	COG0745	RESPONSE REGULATOR receiver
HLAC_RS17750	COG0640	Transcriptional regulator
HLAC_RS17855	COG0776	regulation of translation
HLAC_RS17905	COG4249	Peptidase C14 caspase catalytic subunit p20
HLAC_RS18260	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HLAC_RS18470	COG3422	double-strand break repair