locus-tag	class	description
BB347_RS00015	COG0142	geranyltranstransferase activity
BB347_RS00040	COG1234	tRNA 3'-trailer cleavage
BB347_RS00080	COG0525	valine-tRNA ligase activity
BB347_RS00110	COG1131	(ABC) transporter
BB347_RS00115	COG4347	Protein of unknown function (DUF1405)
BB347_RS00120	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BB347_RS00130	COG0083	homoserine kinase activity
BB347_RS00180	COG2860	membrane
BB347_RS00190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BB347_RS00205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BB347_RS00210	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BB347_RS00225	COG0667	Aldo Keto reductase
BB347_RS00230	COG0385	Bile acid
BB347_RS00235	COG0494	nUDIX hydrolase
BB347_RS00255	COG2339	peptidase activity
BB347_RS00290	COG0210	DNA helicase
BB347_RS00300	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BB347_RS00310	COG1028	Short-chain dehydrogenase reductase Sdr
BB347_RS00330	COG0358	DNA primase activity
BB347_RS00340	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BB347_RS00350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BB347_RS00365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BB347_RS00365	COG1648	precorrin-2 dehydrogenase activity
BB347_RS00370	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BB347_RS00380	COG2154	pterin-4-alpha-carbinolamine dehydratase
BB347_RS00405	COG1295	ribonuclease BN
BB347_RS00410	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
BB347_RS00420	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BB347_RS00425	COG1573	uracil-dna glycosylase
BB347_RS00435	COG0788	formyltetrahydrofolate deformylase activity
BB347_RS00460	COG0523	cobalamin synthesis protein
BB347_RS00465	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BB347_RS00465	COG1918	ferrous iron import across plasma membrane
BB347_RS00485	COG0047	phosphoribosylformylglycinamidine synthase activity
BB347_RS00490	COG4608	Belongs to the ABC transporter superfamily
BB347_RS00495	COG0444	Belongs to the ABC transporter superfamily
BB347_RS00500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BB347_RS00505	COG4174	ABC transporter (Permease)
BB347_RS00540	COG5487	UPF0391 membrane protein
BB347_RS00640	COG4251	negative regulation of phosphorylation
BB347_RS00645	COG0784	Response regulator, receiver
BB347_RS00755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BB347_RS00770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BB347_RS00785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BB347_RS00785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BB347_RS00805	COG0784	Response regulator, receiver
BB347_RS00810	COG0166	Belongs to the GPI family
BB347_RS00830	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BB347_RS00865	COG0504	CTP synthase activity
BB347_RS00870	COG0519	Catalyzes the synthesis of GMP from XMP
BB347_RS00870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BB347_RS00885	COG0521	Mo-molybdopterin cofactor biosynthetic process
BB347_RS00890	COG0604	alcohol dehydrogenase
BB347_RS00890	COG3321	synthase
BB347_RS00890	COG1028	Short-chain dehydrogenase reductase Sdr
BB347_RS00905	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BB347_RS00925	COG0492	ferredoxin-NADP+ reductase activity
BB347_RS00940	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BB347_RS00945	COG0864	Transcriptional regulator
BB347_RS00955	COG1960	acyl-CoA dehydrogenase activity
BB347_RS00960	COG0745	RESPONSE REGULATOR receiver
BB347_RS00980	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BB347_RS00990	COG2171	N-acyltransferase activity
BB347_RS00995	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BB347_RS01000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BB347_RS01005	COG0501	Belongs to the peptidase M48B family
BB347_RS01045	COG0076	glutamate decarboxylase activity
BB347_RS01055	COG0733	neurotransmitter:sodium symporter activity
BB347_RS01060	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BB347_RS01060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BB347_RS01070	COG0469	pyruvate kinase activity
BB347_RS01085	COG0330	HflC and HflK could
BB347_RS01105	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BB347_RS01125	COG1465	3-dehydroquinate synthase
BB347_RS01155	COG1830	Aldolase
BB347_RS01160	COG0159	tryptophan synthase activity
BB347_RS01165	COG0133	tryptophan synthase activity
BB347_RS01170	COG0134	indole-3-glycerol-phosphate synthase activity
BB347_RS01190	COG1067	ATP-dependent peptidase activity
BB347_RS01190	COG0470	DNA polymerase III
BB347_RS01195	COG1056	cytidyltransferase-related domain
BB347_RS01195	COG1051	belongs to the nudix hydrolase family
BB347_RS01210	COG0459	protein refolding
BB347_RS01235	COG1098	S1 RNA binding domain
BB347_RS01275	COG4608	Belongs to the ABC transporter superfamily
BB347_RS01280	COG0444	Belongs to the ABC transporter superfamily
BB347_RS01295	COG4533	DNA binding
BB347_RS01300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BB347_RS01310	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BB347_RS01320	COG0492	ferredoxin-NADP+ reductase activity
BB347_RS01330	COG1363	Peptidase, m42
BB347_RS01335	COG0183	Belongs to the thiolase family
BB347_RS01345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BB347_RS01355	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BB347_RS01360	COG2267	carboxylic ester hydrolase activity
BB347_RS01365	COG1703	isobutyryl-CoA mutase activity
BB347_RS01370	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BB347_RS01370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BB347_RS01435	COG4251	negative regulation of phosphorylation
BB347_RS01495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BB347_RS01505	COG1028	Short-chain dehydrogenase reductase Sdr
BB347_RS01510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BB347_RS01540	COG0010	Belongs to the arginase family
BB347_RS01560	COG1845	cytochrome c oxidase, subunit III
BB347_RS01560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BB347_RS01575	COG1899	peptidyl-lysine modification to peptidyl-hypusine
BB347_RS01585	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BB347_RS01600	COG0303	'Molybdopterin
BB347_RS01645	COG1250	3-hydroxyacyl-CoA dehydrogenase
BB347_RS01650	COG1960	acyl-CoA dehydrogenase activity
BB347_RS01705	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BB347_RS01710	COG0189	ligase activity
BB347_RS01740	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BB347_RS01745	COG1053	succinate dehydrogenase
BB347_RS01755	COG0402	S-adenosylhomocysteine deaminase activity
BB347_RS01780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BB347_RS01790	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
BB347_RS01830	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BB347_RS01835	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BB347_RS01840	COG1776	CheC inhibitor of MCP methylation
BB347_RS01850	COG0643	Histidine kinase
BB347_RS01850	COG2198	Histidine kinase
BB347_RS01855	COG2201	protein-glutamate methylesterase activity
BB347_RS01860	COG2201	protein-glutamate methylesterase activity
BB347_RS01890	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BB347_RS01905	COG2226	methyltransferase
BB347_RS01910	COG0824	Thioesterase
BB347_RS01930	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
BB347_RS01945	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BB347_RS01965	COG1522	sequence-specific DNA binding
BB347_RS01980	COG1013	pyruvate-flavodoxin oxidoreductase activity
BB347_RS01985	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BB347_RS01985	COG0674	pyruvate-flavodoxin oxidoreductase activity
BB347_RS01990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BB347_RS02010	COG0183	Belongs to the thiolase family
BB347_RS02015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BB347_RS02020	COG0006	proline dipeptidase activity
BB347_RS02045	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BB347_RS02100	COG0318	PFAM AMP-dependent synthetase and ligase
BB347_RS02125	COG1454	alcohol dehydrogenase
BB347_RS02130	COG4251	negative regulation of phosphorylation
BB347_RS02135	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BB347_RS02140	COG0602	queuosine metabolic process
BB347_RS02155	COG1058	Belongs to the CinA family
BB347_RS02155	COG1546	Belongs to the CinA family
BB347_RS02170	COG2814	Major facilitator Superfamily
BB347_RS02200	COG0501	Belongs to the peptidase M48B family
BB347_RS02205	COG0644	oxidoreductase
BB347_RS02230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BB347_RS02255	COG0589	response to stress
BB347_RS02260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BB347_RS02270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BB347_RS02275	COG0512	Glutamine amidotransferase of anthranilate synthase
BB347_RS02305	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BB347_RS02340	COG0616	signal peptide processing
BB347_RS02380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BB347_RS02395	COG1196	nuclear chromosome segregation
BB347_RS02405	COG0534	Mate efflux family protein
BB347_RS02420	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BB347_RS02430	COG0384	phenazine biosynthesis protein PhzF
BB347_RS02440	COG1028	Short-chain dehydrogenase reductase Sdr
BB347_RS02445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BB347_RS02455	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BB347_RS02460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BB347_RS02470	COG0559	Belongs to the binding-protein-dependent transport system permease family
BB347_RS02515	COG1233	COG1233 Phytoene dehydrogenase and related
BB347_RS02535	COG1215	transferase activity, transferring glycosyl groups
BB347_RS02560	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BB347_RS02580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BB347_RS02595	COG0494	nUDIX hydrolase
BB347_RS02605	COG1215	transferase activity, transferring glycosyl groups
BB347_RS02620	COG1012	belongs to the aldehyde dehydrogenase family
BB347_RS02635	COG1960	acyl-CoA dehydrogenase activity
BB347_RS02660	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BB347_RS02680	COG2030	dehydratase
BB347_RS02695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BB347_RS02710	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BB347_RS02715	COG1830	Aldolase
BB347_RS02725	COG1250	3-hydroxyacyl-CoA dehydrogenase
BB347_RS02745	COG1960	acyl-CoA dehydrogenase activity
BB347_RS02770	COG0109	protoheme IX farnesyltransferase activity
BB347_RS02780	COG0667	Aldo Keto reductase
BB347_RS02865	COG1215	transferase activity, transferring glycosyl groups
BB347_RS02910	COG4251	negative regulation of phosphorylation
BB347_RS02940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BB347_RS02965	COG0495	leucyl-tRNA aminoacylation
BB347_RS02980	COG0436	Aminotransferase
BB347_RS02985	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BB347_RS02995	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BB347_RS03000	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BB347_RS03005	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BB347_RS03010	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BB347_RS03015	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BB347_RS03015	COG0649	NAD binding
BB347_RS03015	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BB347_RS03040	COG0713	ATP synthesis coupled electron transport
BB347_RS03070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BB347_RS03070	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BB347_RS03090	COG2234	aminopeptidase activity
BB347_RS03095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BB347_RS03125	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BB347_RS03145	COG3842	ATPase activity
BB347_RS03155	COG2226	methyltransferase
BB347_RS03165	COG4251	negative regulation of phosphorylation
BB347_RS03205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BB347_RS03295	COG1012	belongs to the aldehyde dehydrogenase family
BB347_RS03355	COG0109	protoheme IX farnesyltransferase activity
BB347_RS03365	COG1832	CoA-binding protein
BB347_RS03385	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
BB347_RS03415	COG1797	cobyrinic acid a,c-diamide synthase activity
BB347_RS03465	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
BB347_RS03505	COG0589	response to stress
BB347_RS03515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BB347_RS03525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BB347_RS03535	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BB347_RS03570	COG0318	PFAM AMP-dependent synthetase and ligase
BB347_RS03580	COG0717	Belongs to the dCTP deaminase family
BB347_RS03600	COG0585	pseudouridine synthase activity
BB347_RS03605	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BB347_RS03660	COG0519	Catalyzes the synthesis of GMP from XMP
BB347_RS03660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BB347_RS03665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BB347_RS03675	COG0420	3'-5' exonuclease activity
BB347_RS03680	COG0419	ATPase involved in DNA repair
BB347_RS03705	COG0396	ATPase activity
BB347_RS03710	COG0719	Fe-S assembly protein
BB347_RS03715	COG0719	Fe-S assembly protein
BB347_RS03730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BB347_RS03750	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BB347_RS03765	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BB347_RS03785	COG1063	alcohol dehydrogenase
BB347_RS03805	COG0081	regulation of translation
BB347_RS03825	COG0434	BtpA family
BB347_RS03830	COG1902	pentaerythritol trinitrate reductase activity
BB347_RS03850	COG1522	sequence-specific DNA binding
BB347_RS03855	COG0436	Aminotransferase
BB347_RS03875	COG0745	RESPONSE REGULATOR receiver
BB347_RS03880	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BB347_RS03890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BB347_RS03900	COG0667	Aldo Keto reductase
BB347_RS03975	COG0489	protein tyrosine kinase activity
BB347_RS04005	COG0534	Mate efflux family protein
BB347_RS04025	COG4865	methylaspartate mutase activity
BB347_RS04035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BB347_RS04055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BB347_RS04065	COG4251	negative regulation of phosphorylation
BB347_RS04090	COG0126	phosphoglycerate kinase activity
BB347_RS04110	COG0589	response to stress
BB347_RS04115	COG0318	PFAM AMP-dependent synthetase and ligase
BB347_RS04120	COG1024	Enoyl-CoA hydratase
BB347_RS04190	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BB347_RS04195	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BB347_RS04205	COG0783	Belongs to the Dps family
BB347_RS04235	COG1121	(ABC) transporter
BB347_RS04240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BB347_RS04275	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BB347_RS04290	COG1024	Enoyl-CoA hydratase
BB347_RS04305	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
BB347_RS04310	COG0540	Belongs to the ATCase OTCase family
BB347_RS04320	COG1047	Peptidyl-prolyl cis-trans
BB347_RS04330	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
BB347_RS04345	COG0301	tRNA thio-modification
BB347_RS04360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BB347_RS04380	COG1331	Highly conserved protein containing a thioredoxin domain
BB347_RS04390	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BB347_RS04395	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BB347_RS04400	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BB347_RS04415	COG1205	dead DEAH box helicase
BB347_RS04415	COG1111	helicase
BB347_RS04420	COG0151	Belongs to the GarS family
BB347_RS04430	COG1285	pathogenesis
BB347_RS04455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BB347_RS04465	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BB347_RS04485	COG2890	protein-(glutamine-N5) methyltransferase activity
BB347_RS04510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BB347_RS04550	COG4770	biotin carboxylase activity
BB347_RS04580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BB347_RS04585	COG0733	neurotransmitter:sodium symporter activity
BB347_RS04595	COG0784	Response regulator, receiver
BB347_RS04600	COG0584	glycerophosphoryl diester phosphodiesterase
BB347_RS04605	COG0432	Pfam Uncharacterised protein family UPF0047
BB347_RS04615	COG2719	SpoVR family
BB347_RS04620	COG2718	Belongs to the UPF0229 family
BB347_RS04630	COG2766	serine protein kinase
BB347_RS04645	COG0587	DNA-directed DNA polymerase activity
BB347_RS04650	COG0367	asparagine synthase
BB347_RS04660	COG0489	protein tyrosine kinase activity
BB347_RS04680	COG0437	4 iron, 4 sulfur cluster binding
BB347_RS04690	COG0596	Alpha beta hydrolase
BB347_RS04700	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BB347_RS04705	COG0154	amidase activity
BB347_RS04720	COG0318	PFAM AMP-dependent synthetase and ligase
BB347_RS04730	COG1575	Belongs to the MenA family. Type 1 subfamily
BB347_RS04775	COG0484	heat shock protein binding
BB347_RS04780	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BB347_RS04785	COG1169	isochorismate synthase
BB347_RS04790	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BB347_RS04810	COG0107	imidazoleglycerol-phosphate synthase activity
BB347_RS04830	COG1136	(ABC) transporter
BB347_RS04830	COG0577	efflux transmembrane transporter activity
BB347_RS04845	COG2264	protein methyltransferase activity
BB347_RS04895	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BB347_RS04905	COG0114	fumarate hydratase activity
BB347_RS04940	COG0215	cysteine-tRNA ligase activity
BB347_RS04970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BB347_RS04975	COG1120	ATPase activity
BB347_RS04985	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BB347_RS05010	COG0542	response to heat
BB347_RS05035	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BB347_RS05050	COG1082	Xylose isomerase domain protein TIM barrel
BB347_RS05065	COG3842	ATPase activity
BB347_RS05070	COG1176	ABC-type spermidine putrescine transport system, permease component I
BB347_RS05090	COG0668	transmembrane transport
BB347_RS05115	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BB347_RS05120	COG3360	Dodecin
BB347_RS05125	COG0316	Belongs to the HesB IscA family
BB347_RS05135	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BB347_RS05170	COG3546	catalase activity
BB347_RS05180	COG0644	oxidoreductase
BB347_RS05240	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BB347_RS05250	COG1793	dna ligase
BB347_RS05255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BB347_RS05265	COG1213	nucleotidyl transferase
BB347_RS05265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BB347_RS05320	COG0071	Belongs to the small heat shock protein (HSP20) family
BB347_RS05340	COG0405	Gamma-glutamyltransferase
BB347_RS05370	COG0431	NADPH-dependent FMN reductase
BB347_RS05400	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BB347_RS05400	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BB347_RS05410	COG0129	dihydroxy-acid dehydratase activity
BB347_RS05435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BB347_RS05440	COG0484	heat shock protein binding
BB347_RS05480	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BB347_RS05505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BB347_RS05525	COG0531	amino acid
BB347_RS05530	COG0531	amino acid
BB347_RS05540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BB347_RS05550	COG0483	inositol monophosphate 1-phosphatase activity
BB347_RS05585	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BB347_RS05615	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BB347_RS05635	COG2255	four-way junction helicase activity
BB347_RS05640	COG1546	Belongs to the CinA family
BB347_RS05640	COG1058	Belongs to the CinA family
BB347_RS05670	COG0509	glycine decarboxylation via glycine cleavage system
BB347_RS05675	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BB347_RS05705	COG0175	sulfate reduction
BB347_RS05725	COG0154	amidase activity
BB347_RS05730	COG1960	acyl-CoA dehydrogenase activity
BB347_RS05735	COG0644	oxidoreductase
BB347_RS05760	COG0346	lactoylglutathione lyase activity
BB347_RS05765	COG0784	Response regulator, receiver
BB347_RS05775	COG1278	Cold shock
BB347_RS05780	COG0534	Mate efflux family protein
BB347_RS05830	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BB347_RS05835	COG0443	Heat shock 70 kDa protein
BB347_RS05840	COG0484	heat shock protein binding
BB347_RS05895	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BB347_RS05895	COG0165	Argininosuccinate lyase
BB347_RS05900	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BB347_RS05900	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BB347_RS05905	COG0346	lactoylglutathione lyase activity
BB347_RS05920	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BB347_RS05920	COG0674	pyruvate-flavodoxin oxidoreductase activity
BB347_RS05925	COG1013	pyruvate-flavodoxin oxidoreductase activity
BB347_RS05950	COG0489	protein tyrosine kinase activity
BB347_RS05965	COG0437	4 iron, 4 sulfur cluster binding
BB347_RS05970	COG0633	Ferredoxin
BB347_RS05990	COG0693	protein deglycase activity
BB347_RS05995	COG0604	alcohol dehydrogenase
BB347_RS06005	COG1476	TRANSCRIPTIONal
BB347_RS06025	COG0501	Belongs to the peptidase M48B family
BB347_RS06060	COG0252	asparaginase activity
BB347_RS06110	COG0784	Response regulator, receiver
BB347_RS06115	COG4251	negative regulation of phosphorylation
BB347_RS06130	COG0516	GMP reductase activity
BB347_RS06130	COG0517	IMP dehydrogenase activity
BB347_RS06135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BB347_RS06150	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BB347_RS06225	COG0512	Glutamine amidotransferase of anthranilate synthase
BB347_RS06225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BB347_RS06230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BB347_RS06235	COG0135	phosphoribosylanthranilate isomerase activity
BB347_RS06250	COG0534	Mate efflux family protein
BB347_RS06305	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BB347_RS06310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BB347_RS06335	COG4608	Belongs to the ABC transporter superfamily
BB347_RS06340	COG0444	Belongs to the ABC transporter superfamily
BB347_RS06350	COG0601	transmembrane transport
BB347_RS06355	COG0747	negative chemotaxis
BB347_RS06365	COG0673	inositol 2-dehydrogenase activity
BB347_RS06415	COG0546	phosphoglycolate phosphatase activity
BB347_RS06440	COG0531	amino acid
BB347_RS06445	COG1803	Methylglyoxal synthase
BB347_RS06470	COG0284	orotidine-5'-phosphate decarboxylase activity
BB347_RS06485	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BB347_RS06500	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
BB347_RS06535	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BB347_RS06545	COG0089	rRNA binding
BB347_RS06550	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BB347_RS06555	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BB347_RS06565	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BB347_RS06570	COG0255	Belongs to the universal ribosomal protein uL29 family
BB347_RS06580	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BB347_RS06585	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BB347_RS06600	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BB347_RS06610	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BB347_RS06635	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BB347_RS06645	COG0200	Binds to the 23S rRNA
BB347_RS06665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BB347_RS06665	COG1845	cytochrome c oxidase, subunit III
BB347_RS06680	COG0563	adenylate kinase activity
BB347_RS06700	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BB347_RS06735	COG0110	maltose O-acetyltransferase activity
BB347_RS06740	COG1252	NADH dehydrogenase
BB347_RS06745	COG0010	Belongs to the arginase family
BB347_RS06770	COG0187	DNA topoisomerase II activity
BB347_RS06775	COG0405	Gamma-glutamyltransferase
BB347_RS06785	COG0589	response to stress
BB347_RS06820	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BB347_RS06825	COG0179	Fumarylacetoacetate (FAA) hydrolase
BB347_RS06865	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BB347_RS06900	COG1177	transmembrane transport
BB347_RS06905	COG1176	ABC-type spermidine putrescine transport system, permease component I
BB347_RS06910	COG3842	ATPase activity
BB347_RS06925	COG0644	oxidoreductase
BB347_RS06935	COG2086	electron transfer activity
BB347_RS06970	COG0628	permease
BB347_RS06980	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BB347_RS06985	COG0483	inositol monophosphate 1-phosphatase activity
BB347_RS07000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BB347_RS07045	COG3920	Histidine kinase
BB347_RS07050	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BB347_RS07075	COG1414	Transcriptional regulator
BB347_RS07085	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BB347_RS07095	COG0395	ABC-type sugar transport system, permease component
BB347_RS07100	COG3842	ATPase activity
BB347_RS07115	COG0531	amino acid
BB347_RS07145	COG1028	Short-chain dehydrogenase reductase Sdr
BB347_RS07150	COG0318	PFAM AMP-dependent synthetase and ligase
BB347_RS07160	COG1250	3-hydroxyacyl-CoA dehydrogenase
BB347_RS07175	COG0183	Belongs to the thiolase family
BB347_RS07185	COG0318	PFAM AMP-dependent synthetase and ligase
BB347_RS07290	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BB347_RS07300	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
BB347_RS07315	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BB347_RS07320	COG1177	transmembrane transport
BB347_RS07325	COG1176	ABC-type spermidine putrescine transport system, permease component I
BB347_RS07330	COG3842	ATPase activity
BB347_RS07340	COG0778	Nitroreductase
BB347_RS07370	COG0010	Belongs to the arginase family
BB347_RS07380	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BB347_RS07410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BB347_RS07425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BB347_RS07445	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BB347_RS07460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BB347_RS07470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BB347_RS07505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BB347_RS07530	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BB347_RS07535	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BB347_RS07540	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BB347_RS07565	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BB347_RS07580	COG0148	phosphopyruvate hydratase activity
BB347_RS07585	COG0052	Belongs to the universal ribosomal protein uS2 family
BB347_RS07625	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BB347_RS07635	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BB347_RS07645	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BB347_RS07650	COG0142	geranyltranstransferase activity
BB347_RS07655	COG0668	transmembrane transport
BB347_RS07675	COG4221	oxidoreductase activity
BB347_RS07680	COG1444	tRNA N-acetyltransferase activity
BB347_RS07700	COG0105	UTP biosynthetic process
BB347_RS07710	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BB347_RS07715	COG3852	Histidine kinase
BB347_RS07745	COG1074	ATP-dependent DNA helicase activity
BB347_RS07810	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BB347_RS07825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BB347_RS07830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BB347_RS07850	COG0437	4 iron, 4 sulfur cluster binding
BB347_RS07855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BB347_RS07865	COG0573	inorganic phosphate transmembrane transporter activity
BB347_RS07875	COG0704	Plays a role in the regulation of phosphate uptake
BB347_RS07890	COG0280	phosphate acetyltransferase
BB347_RS07890	COG0281	malic enzyme
BB347_RS07980	COG1744	ABC transporter substrate-binding protein PnrA-like
BB347_RS07985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BB347_RS08010	COG3243	poly(R)-hydroxyalkanoic acid synthase
BB347_RS08015	COG1028	Short-chain dehydrogenase reductase Sdr
BB347_RS08025	COG0315	cyclic pyranopterin monophosphate synthase activity
BB347_RS08030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BB347_RS08030	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BB347_RS08040	COG1254	Belongs to the acylphosphatase family
BB347_RS08075	COG0492	ferredoxin-NADP+ reductase activity
BB347_RS08080	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BB347_RS08085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BB347_RS08115	COG1132	(ABC) transporter
BB347_RS08120	COG0438	transferase activity, transferring glycosyl groups
BB347_RS08135	COG2264	protein methyltransferase activity
BB347_RS08155	COG0297	glycogen (starch) synthase activity
BB347_RS08200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BB347_RS08225	COG1757	Na H antiporter
BB347_RS08230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BB347_RS08260	COG2252	PERMEase
BB347_RS08265	COG2379	hydroxypyruvate reductase
BB347_RS08290	COG0435	Glutathione S-transferase
BB347_RS08300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BB347_RS08305	COG1414	Transcriptional regulator
BB347_RS08310	COG0154	amidase activity
BB347_RS08320	COG1078	dGTPase activity
BB347_RS08350	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BB347_RS08365	COG2890	protein-(glutamine-N5) methyltransferase activity
BB347_RS08370	COG0668	transmembrane transport
BB347_RS08385	COG1960	acyl-CoA dehydrogenase activity
BB347_RS08405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BB347_RS08440	COG0628	permease
BB347_RS08465	COG0501	Belongs to the peptidase M48B family
BB347_RS08485	COG1546	Belongs to the CinA family
BB347_RS08485	COG1058	Belongs to the CinA family
BB347_RS08490	COG0436	Aminotransferase
BB347_RS08500	COG0003	Pfam Anion-transporting ATPase
BB347_RS08520	COG0471	metal ion transport
BB347_RS08530	COG0300	oxidoreductase activity
BB347_RS08535	COG1515	deoxyribonuclease V activity
BB347_RS08550	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BB347_RS08550	COG1796	DNA polymerase
BB347_RS08595	COG3387	PFAM Glycoside hydrolase 15-related
BB347_RS08605	COG4948	Mandelate Racemase Muconate Lactonizing
BB347_RS08615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BB347_RS08635	COG1028	Short-chain dehydrogenase reductase Sdr
BB347_RS08645	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BB347_RS08650	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BB347_RS08675	COG0589	response to stress
BB347_RS08680	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BB347_RS08680	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BB347_RS08690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BB347_RS08705	COG2226	methyltransferase
BB347_RS08720	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BB347_RS08745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BB347_RS08745	COG3321	synthase
BB347_RS08745	COG4221	oxidoreductase activity
BB347_RS08745	COG0604	alcohol dehydrogenase
BB347_RS08750	COG0017	Asparaginyl-tRNA synthetase
BB347_RS08755	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BB347_RS08765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BB347_RS08790	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BB347_RS08810	COG0561	phosphatase activity
BB347_RS08825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BB347_RS08830	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
BB347_RS08835	COG0247	lactate metabolic process
BB347_RS08855	COG1216	Glycosyl transferase, family 2
BB347_RS08890	COG0006	proline dipeptidase activity
BB347_RS08895	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BB347_RS08915	COG0247	lactate metabolic process
BB347_RS08915	COG0277	FAD linked oxidase domain protein
BB347_RS08925	COG1473	amidohydrolase
BB347_RS08930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BB347_RS08945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BB347_RS08960	COG1473	amidohydrolase
BB347_RS08975	COG0506	proline dehydrogenase activity
BB347_RS09045	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BB347_RS09065	COG4251	negative regulation of phosphorylation
BB347_RS09085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BB347_RS09090	COG1028	Short-chain dehydrogenase reductase Sdr
BB347_RS09100	COG1011	Hydrolase
BB347_RS09135	COG1250	3-hydroxyacyl-CoA dehydrogenase
BB347_RS09150	COG1201	RNA secondary structure unwinding
BB347_RS09205	COG0482	sulfurtransferase activity
BB347_RS09225	COG1178	ABC-type Fe3 transport system permease component
BB347_RS09230	COG3842	ATPase activity
BB347_RS09250	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BB347_RS09265	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BB347_RS09285	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BB347_RS09310	COG1122	ATPase activity
BB347_RS09325	COG0446	pyridine nucleotide-disulphide oxidoreductase
BB347_RS09330	COG4251	negative regulation of phosphorylation
BB347_RS09450	COG2267	carboxylic ester hydrolase activity
BB347_RS09460	COG0473	3-isopropylmalate dehydrogenase activity
BB347_RS09470	COG0066	3-isopropylmalate dehydratase activity
BB347_RS09475	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BB347_RS09485	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BB347_RS09490	COG0440	acetolactate synthase activity
BB347_RS09495	COG0028	Belongs to the TPP enzyme family
BB347_RS09500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BB347_RS09505	COG1522	sequence-specific DNA binding
BB347_RS09520	COG3685	Protein conserved in bacteria
BB347_RS09555	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BB347_RS09570	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BB347_RS09580	COG1011	Hydrolase
BB347_RS09595	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BB347_RS09615	COG1404	Belongs to the peptidase S8 family
BB347_RS09620	COG0513	Belongs to the DEAD box helicase family
BB347_RS09640	COG0095	Lipoate-protein ligase
BB347_RS09650	COG2226	methyltransferase
BB347_RS09665	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BB347_RS09685	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BB347_RS09720	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BB347_RS09765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BB347_RS09770	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BB347_RS09775	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BB347_RS09785	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BB347_RS09820	COG1404	Belongs to the peptidase S8 family
BB347_RS09840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BB347_RS09845	COG0037	tRNA processing
BB347_RS09875	COG1131	(ABC) transporter
BB347_RS09885	COG2226	methyltransferase
BB347_RS09895	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BB347_RS09905	COG0012	GTP binding
BB347_RS09915	COG0189	ligase activity
BB347_RS09935	COG1966	Carbon starvation protein
BB347_RS09940	COG0003	Pfam Anion-transporting ATPase
BB347_RS09950	COG0523	cobalamin synthesis protein
BB347_RS10025	COG0318	PFAM AMP-dependent synthetase and ligase
BB347_RS10030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BB347_RS10035	COG0174	glutamine synthetase
BB347_RS10045	COG0459	protein refolding
BB347_RS10050	COG2135	peptidase activity
BB347_RS10065	COG0251	oxidation-reduction process
BB347_RS10070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BB347_RS10075	COG0372	Belongs to the citrate synthase family
BB347_RS10100	COG0557	exoribonuclease II activity
BB347_RS10115	COG0430	RNA-3'-phosphate cyclase activity
BB347_RS10130	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BB347_RS10135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BB347_RS10140	COG1028	Short-chain dehydrogenase reductase Sdr
BB347_RS10145	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BB347_RS10150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BB347_RS10150	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BB347_RS10160	COG0351	phosphomethylpyrimidine kinase
BB347_RS10185	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BB347_RS10200	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BB347_RS10240	COG0051	transcription antitermination factor activity, RNA binding
BB347_RS10245	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BB347_RS10250	COG0460	homoserine dehydrogenase
BB347_RS10305	COG1335	isochorismatase
BB347_RS10335	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BB347_RS10355	COG0589	response to stress
BB347_RS10380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BB347_RS10400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BB347_RS10445	COG1074	ATP-dependent DNA helicase activity
BB347_RS10460	COG1051	belongs to the nudix hydrolase family
BB347_RS10480	COG0442	prolyl-tRNA aminoacylation
BB347_RS10485	COG0070	glutamate synthase
BB347_RS10485	COG0069	glutamate synthase activity
BB347_RS10485	COG0067	glutamate synthase
BB347_RS10490	COG0668	transmembrane transport
BB347_RS10500	COG0371	Dehydrogenase
BB347_RS10510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BB347_RS10530	COG0445	tRNA wobble uridine modification
BB347_RS10550	COG3383	formate dehydrogenase (NAD+) activity
BB347_RS10555	COG0437	4 iron, 4 sulfur cluster binding
BB347_RS10575	COG1505	serine-type exopeptidase activity
BB347_RS10590	COG0133	tryptophan synthase activity
BB347_RS10595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BB347_RS10600	COG0581	inorganic phosphate transmembrane transporter activity
BB347_RS10605	COG0573	inorganic phosphate transmembrane transporter activity
BB347_RS10615	COG2855	membrane
BB347_RS10620	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BB347_RS10620	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BB347_RS10620	COG0649	NAD binding
BB347_RS10650	COG2894	cell division
BB347_RS10660	COG0018	arginyl-trna synthetase
BB347_RS10665	COG0572	uridine kinase
BB347_RS10670	COG1051	belongs to the nudix hydrolase family
BB347_RS10690	COG1960	acyl-CoA dehydrogenase activity
BB347_RS10705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BB347_RS10705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BB347_RS10735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BB347_RS10755	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BB347_RS10760	COG0477	Major facilitator Superfamily
BB347_RS10765	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BB347_RS10770	COG1028	Short-chain dehydrogenase reductase Sdr
BB347_RS10780	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BB347_RS10800	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BB347_RS10835	COG2873	o-acetylhomoserine
BB347_RS10850	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BB347_RS10855	COG3011	Protein conserved in bacteria
BB347_RS10960	COG0247	lactate metabolic process
BB347_RS10960	COG0277	FAD linked oxidase domain protein
BB347_RS10965	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BB347_RS10975	COG1028	Short-chain dehydrogenase reductase Sdr
BB347_RS10980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BB347_RS11005	COG1454	alcohol dehydrogenase
BB347_RS11055	COG4948	Mandelate Racemase Muconate Lactonizing
BB347_RS11060	COG0252	asparaginase activity
BB347_RS11080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BB347_RS11085	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BB347_RS11090	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BB347_RS11130	COG0628	permease
BB347_RS11135	COG4124	Belongs to the glycosyl hydrolase 26 family
BB347_RS11135	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BB347_RS11145	COG1215	transferase activity, transferring glycosyl groups
BB347_RS11195	COG0024	Methionine aminopeptidase
BB347_RS11200	COG1446	asparaginase
BB347_RS11225	COG1028	Short-chain dehydrogenase reductase Sdr
BB347_RS11230	COG1914	H( )-stimulated, divalent metal cation uptake system
BB347_RS11265	COG1228	amidohydrolase
BB347_RS11275	COG0673	inositol 2-dehydrogenase activity
BB347_RS11280	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BB347_RS11285	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BB347_RS11295	COG1012	belongs to the aldehyde dehydrogenase family
BB347_RS11320	COG1250	3-hydroxyacyl-CoA dehydrogenase
BB347_RS11335	COG1960	acyl-CoA dehydrogenase activity
BB347_RS11340	COG0318	PFAM AMP-dependent synthetase and ligase
BB347_RS11355	COG1960	acyl-CoA dehydrogenase activity
BB347_RS11360	COG1414	Transcriptional regulator
BB347_RS11380	COG1250	3-hydroxyacyl-CoA dehydrogenase
BB347_RS11385	COG1960	acyl-CoA dehydrogenase activity
BB347_RS11400	COG1024	Enoyl-CoA hydratase
BB347_RS11405	COG0318	PFAM AMP-dependent synthetase and ligase
BB347_RS11410	COG1177	transmembrane transport
BB347_RS11420	COG3842	ATPase activity
BB347_RS11430	COG1024	Enoyl-CoA hydratase
BB347_RS11455	COG1960	acyl-CoA dehydrogenase activity
BB347_RS11460	COG0318	PFAM AMP-dependent synthetase and ligase
BB347_RS11480	COG1028	Short-chain dehydrogenase reductase Sdr
BB347_RS11485	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BB347_RS11490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BB347_RS11510	COG1024	Enoyl-CoA hydratase
BB347_RS11515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BB347_RS11520	COG1960	acyl-CoA dehydrogenase activity
BB347_RS11525	COG0318	PFAM AMP-dependent synthetase and ligase
BB347_RS11555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BB347_RS11560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BB347_RS11570	COG0183	Belongs to the thiolase family
BB347_RS11590	COG1960	acyl-CoA dehydrogenase activity
BB347_RS11595	COG1960	acyl-CoA dehydrogenase activity
BB347_RS11605	COG0426	domain, Protein
BB347_RS11605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BB347_RS11620	COG0604	alcohol dehydrogenase
BB347_RS11620	COG1028	Short-chain dehydrogenase reductase Sdr
BB347_RS11620	COG3321	synthase
BB347_RS11630	COG0183	Belongs to the thiolase family
BB347_RS11705	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BB347_RS11715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BB347_RS11730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BB347_RS11740	COG1024	Enoyl-CoA hydratase
BB347_RS11760	COG0714	Associated with various cellular activities
BB347_RS11780	COG2890	protein-(glutamine-N5) methyltransferase activity
BB347_RS11825	COG0667	Aldo Keto reductase
BB347_RS11855	COG1132	(ABC) transporter
BB347_RS11870	COG2770	Histidine kinase
BB347_RS11870	COG2205	protein histidine kinase activity
BB347_RS11910	COG1305	Transglutaminase-like
BB347_RS11920	COG0714	Associated with various cellular activities
BB347_RS11925	COG1278	Cold shock
BB347_RS11945	COG0778	Nitroreductase
BB347_RS11945	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
BB347_RS11970	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BB347_RS11990	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BB347_RS12005	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BB347_RS12025	COG0084	hydrolase, TatD family'
BB347_RS12065	COG1082	Xylose isomerase domain protein TIM barrel
BB347_RS12100	COG0140	phosphoribosyl-ATP diphosphatase activity
BB347_RS12115	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BB347_RS12120	COG2514	catechol 2,3-dioxygenase activity
BB347_RS12125	COG0745	RESPONSE REGULATOR receiver
BB347_RS12155	COG0085	RNA polymerase activity
BB347_RS12160	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BB347_RS12165	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BB347_RS12185	COG0049	tRNA binding
BB347_RS12215	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BB347_RS12235	COG2239	Acts as a magnesium transporter
BB347_RS12245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BB347_RS12265	COG1022	Amp-dependent synthetase and ligase
BB347_RS12295	COG0183	Belongs to the thiolase family
BB347_RS12330	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BB347_RS12430	COG1131	(ABC) transporter
BB347_RS12435	COG0842	Transport permease protein
BB347_RS12440	COG2130	NADP-dependent
BB347_RS12460	COG1278	Cold shock
BB347_RS12470	COG2249	NAD(P)H dehydrogenase (quinone) activity
BB347_RS12480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BB347_RS12485	COG1120	ATPase activity
BB347_RS12520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BB347_RS12525	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BB347_RS12530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BB347_RS12535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BB347_RS12540	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BB347_RS12545	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BB347_RS12550	COG0189	ligase activity
BB347_RS12560	COG0165	Argininosuccinate lyase
BB347_RS12565	COG0137	argininosuccinate synthase activity
BB347_RS12585	COG2391	methyltransferase activity
BB347_RS12590	COG0425	Belongs to the sulfur carrier protein TusA family
BB347_RS12595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BB347_RS12625	COG2309	aminopeptidase activity
BB347_RS12650	COG0346	lactoylglutathione lyase activity
BB347_RS12655	COG3634	alkyl hydroperoxide reductase activity
BB347_RS12660	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BB347_RS12730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BB347_RS12735	COG2897	thiosulfate sulfurtransferase activity
BB347_RS12760	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BB347_RS12765	COG0352	thiamine-phosphate diphosphorylase activity
BB347_RS12795	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BB347_RS12805	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BB347_RS12845	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BB347_RS12865	COG1131	(ABC) transporter
BB347_RS12885	COG1131	(ABC) transporter
BB347_RS12890	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BB347_RS12900	COG1278	Cold shock
BB347_RS12920	COG0667	Aldo Keto reductase
BB347_RS12960	COG3685	Protein conserved in bacteria
BB347_RS13030	COG0022	dehydrogenase e1 component
BB347_RS13040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BB347_RS13065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BB347_RS13070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BB347_RS13080	COG0402	S-adenosylhomocysteine deaminase activity
BB347_RS13085	COG0179	Fumarylacetoacetate (FAA) hydrolase
BB347_RS13115	COG0693	protein deglycase activity
BB347_RS13125	COG1694	Mazg nucleotide pyrophosphohydrolase
BB347_RS13130	COG1078	dGTPase activity
BB347_RS13145	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BB347_RS13150	COG3639	organic phosphonate transmembrane transporter activity
BB347_RS13155	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BB347_RS13235	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BB347_RS13280	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BB347_RS13285	COG0390	transport system, permease component
BB347_RS13295	COG0556	nucleotide-excision repair
BB347_RS13310	COG0023	Translation Initiation Factor
BB347_RS13350	COG0427	acetyl-CoA hydrolase
BB347_RS13365	COG1414	Transcriptional regulator
BB347_RS13375	COG0322	excinuclease ABC activity
BB347_RS13390	COG1131	(ABC) transporter
BB347_RS13405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BB347_RS13420	COG0737	Belongs to the 5'-nucleotidase family
BB347_RS13440	COG2031	fatty acid transporter
BB347_RS13445	COG0459	protein refolding
BB347_RS13455	COG3361	conserved protein (COG2071)
BB347_RS13465	COG3290	protein histidine kinase activity
BB347_RS13465	COG0840	transmembrane signaling receptor activity
BB347_RS13470	COG0495	leucyl-tRNA aminoacylation
BB347_RS13485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BB347_RS13500	COG1605	Chorismate mutase
BB347_RS13500	COG0077	Prephenate dehydratase
BB347_RS13505	COG2346	COG2346, Truncated hemoglobins
BB347_RS13510	COG0181	hydroxymethylbilane synthase activity
BB347_RS13515	COG1648	precorrin-2 dehydrogenase activity
BB347_RS13515	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BB347_RS13535	COG0587	DNA-directed DNA polymerase activity
BB347_RS13555	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BB347_RS13685	COG0601	transmembrane transport
BB347_RS13695	COG0444	Belongs to the ABC transporter superfamily
BB347_RS13720	COG4109	DRTGG domain
BB347_RS13725	COG0423	glycine-tRNA ligase activity
BB347_RS13775	COG0556	nucleotide-excision repair
BB347_RS13790	COG0475	glutathione-regulated potassium exporter activity
BB347_RS13790	COG0589	response to stress
BB347_RS13810	COG0039	L-malate dehydrogenase activity
BB347_RS13835	COG1902	pentaerythritol trinitrate reductase activity
BB347_RS13855	COG0622	Phosphoesterase
BB347_RS13860	COG1045	serine acetyltransferase
BB347_RS13875	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BB347_RS13900	COG4149	molybdate abc transporter
BB347_RS13910	COG2226	methyltransferase
BB347_RS13940	COG0577	efflux transmembrane transporter activity
BB347_RS13945	COG1136	(ABC) transporter
BB347_RS13965	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BB347_RS13975	COG1304	FMN binding
BB347_RS13985	COG1691	(AIR) carboxylase
BB347_RS13990	COG2827	Endonuclease containing a URI domain
BB347_RS14000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BB347_RS14025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BB347_RS14035	COG0527	aspartate kinase activity
BB347_RS14045	COG3033	Beta-eliminating lyase
BB347_RS14085	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BB347_RS14090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BB347_RS14100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BB347_RS14100	COG0519	Catalyzes the synthesis of GMP from XMP
BB347_RS14105	COG0247	lactate metabolic process
BB347_RS14105	COG2181	nitrate reductase activity
BB347_RS14125	COG0009	L-threonylcarbamoyladenylate synthase
BB347_RS14150	COG1607	acyl-coa hydrolase
BB347_RS14155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BB347_RS14165	COG1234	tRNA 3'-trailer cleavage
BB347_RS14205	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BB347_RS14225	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BB347_RS14245	COG2873	o-acetylhomoserine
BB347_RS14250	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BB347_RS14265	COG0560	Phosphoserine phosphatase
BB347_RS14285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BB347_RS14295	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BB347_RS14305	COG4251	negative regulation of phosphorylation
BB347_RS14320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BB347_RS14350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BB347_RS14365	COG0537	adenosine 5'-monophosphoramidase activity
BB347_RS14395	COG1414	Transcriptional regulator
BB347_RS14400	COG1960	acyl-CoA dehydrogenase activity
BB347_RS14420	COG3246	L-lysine catabolic process to acetate
BB347_RS14425	COG0277	FAD linked oxidase domain protein
BB347_RS14430	COG4948	Mandelate Racemase Muconate Lactonizing
BB347_RS14440	COG0456	acetyltransferase
BB347_RS14445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BB347_RS14450	COG4948	Mandelate Racemase Muconate Lactonizing
BB347_RS14455	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BB347_RS14465	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BB347_RS14480	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BB347_RS14485	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BB347_RS14495	COG0318	PFAM AMP-dependent synthetase and ligase
BB347_RS14500	COG1960	acyl-CoA dehydrogenase activity
BB347_RS14525	COG1024	Enoyl-CoA hydratase
BB347_RS14535	COG1028	Short-chain dehydrogenase reductase Sdr
BB347_RS14570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BB347_RS14595	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BB347_RS14600	COG3321	synthase
BB347_RS14600	COG0604	alcohol dehydrogenase
BB347_RS14600	COG1028	Short-chain dehydrogenase reductase Sdr
BB347_RS14625	COG0346	lactoylglutathione lyase activity
BB347_RS14645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BB347_RS14655	COG2814	Major facilitator Superfamily
BB347_RS14660	COG1960	acyl-CoA dehydrogenase activity
BB347_RS14665	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BB347_RS14675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BB347_RS14685	COG0028	Belongs to the TPP enzyme family
BB347_RS14695	COG1024	Enoyl-CoA hydratase
BB347_RS14735	COG4948	Mandelate Racemase Muconate Lactonizing
BB347_RS14740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BB347_RS14750	COG0589	response to stress
BB347_RS14755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BB347_RS14760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BB347_RS14785	COG2814	Major facilitator Superfamily
BB347_RS14825	COG3273	potassium ion transport
BB347_RS14825	COG0471	metal ion transport
BB347_RS14830	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BB347_RS14835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BB347_RS14845	COG0131	Imidazoleglycerol-phosphate dehydratase
BB347_RS14865	COG1739	Uncharacterized protein family UPF0029
BB347_RS14885	COG2358	TRAP transporter, solute receptor (TAXI family
BB347_RS14890	COG0823	Involved in the tonB-independent uptake of proteins
BB347_RS14890	COG1506	peptidase
BB347_RS14890	COG4946	Tricorn protease homolog
BB347_RS14905	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BB347_RS14935	COG0116	Belongs to the methyltransferase superfamily
BB347_RS14935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BB347_RS14955	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BB347_RS14960	COG2217	Heavy metal translocating P-type atpase
BB347_RS15020	COG0402	S-adenosylhomocysteine deaminase activity
BB347_RS15030	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BB347_RS15065	COG2267	carboxylic ester hydrolase activity
BB347_RS15110	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BB347_RS15120	COG0589	response to stress
BB347_RS15120	COG0475	glutathione-regulated potassium exporter activity
BB347_RS15125	COG0805	protein transport
BB347_RS15130	COG0805	protein transport
BB347_RS15145	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BB347_RS15160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BB347_RS15170	COG1606	tRNA processing
BB347_RS15185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BB347_RS15195	COG0004	ammonium transporteR
BB347_RS15200	COG0113	porphobilinogen synthase activity
BB347_RS15275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BB347_RS15290	COG0501	Belongs to the peptidase M48B family
BB347_RS15310	COG0822	iron-sulfur transferase activity
BB347_RS15320	COG1418	mRNA catabolic process
BB347_RS15325	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BB347_RS15385	COG0701	Predicted permease
BB347_RS15420	COG4166	transmembrane transport
BB347_RS15425	COG0521	Mo-molybdopterin cofactor biosynthetic process
BB347_RS15430	COG0523	cobalamin synthesis protein
BB347_RS15435	COG0523	cobalamin synthesis protein
BB347_RS15455	COG0123	including yeast histone deacetylase and acetoin utilization protein
BB347_RS15530	COG1335	isochorismatase
BB347_RS15570	COG1028	Short-chain dehydrogenase reductase Sdr
BB347_RS15580	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BB347_RS15590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BB347_RS15600	COG1028	Short-chain dehydrogenase reductase Sdr
BB347_RS15630	COG0501	Belongs to the peptidase M48B family
BB347_RS15635	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BB347_RS15650	COG0318	PFAM AMP-dependent synthetase and ligase
BB347_RS15700	COG1121	(ABC) transporter
BB347_RS15730	COG0723	plastoquinol--plastocyanin reductase activity
BB347_RS15730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BB347_RS15745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BB347_RS15765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BB347_RS15785	COG3119	arylsulfatase activity
BB347_RS15830	COG0314	molybdopterin synthase activity
BB347_RS15835	COG0528	UMP kinase activity
BB347_RS15885	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BB347_RS15905	COG0534	Mate efflux family protein
BB347_RS15930	COG0179	Fumarylacetoacetate (FAA) hydrolase
BB347_RS15945	COG1185	polyribonucleotide nucleotidyltransferase activity
BB347_RS15975	COG0581	inorganic phosphate transmembrane transporter activity
BB347_RS15980	COG0573	inorganic phosphate transmembrane transporter activity
BB347_RS15995	COG1785	Belongs to the alkaline phosphatase family
BB347_RS16000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BB347_RS16020	COG4251	negative regulation of phosphorylation
BB347_RS16080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BB347_RS16090	COG0464	growth
BB347_RS16110	COG0589	response to stress
BB347_RS16155	COG0534	Mate efflux family protein
BB347_RS16185	COG2271	Major facilitator Superfamily
BB347_RS16230	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BB347_RS16255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BB347_RS16295	COG3119	arylsulfatase activity
BB347_RS16300	COG0101	tRNA pseudouridine synthase activity
BB347_RS16315	COG4251	negative regulation of phosphorylation
BB347_RS16325	COG1164	Oligoendopeptidase f
BB347_RS16345	COG0405	Gamma-glutamyltransferase
BB347_RS16360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BB347_RS16405	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
BB347_RS16430	COG1269	ATP hydrolysis coupled proton transport
BB347_RS16440	COG2226	methyltransferase
BB347_RS16470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BB347_RS16575	COG0174	glutamine synthetase
BB347_RS16670	COG0589	response to stress
BB347_RS16695	COG2391	methyltransferase activity
BB347_RS16700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BB347_RS16700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BB347_RS16705	COG0425	Belongs to the sulfur carrier protein TusA family
BB347_RS16710	COG2210	Belongs to the sulfur carrier protein TusA family
BB347_RS16715	COG0668	transmembrane transport
BB347_RS16720	COG0330	HflC and HflK could
BB347_RS16745	COG1131	(ABC) transporter
BB347_RS16760	COG1492	cobalamin metabolic process
BB347_RS16790	COG0561	phosphatase activity
BB347_RS16790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BB347_RS16795	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BB347_RS16850	COG1201	RNA secondary structure unwinding
BB347_RS16855	COG4251	negative regulation of phosphorylation
BB347_RS16860	COG0688	phosphatidylethanolamine metabolic process
BB347_RS16885	COG1132	(ABC) transporter
BB347_RS16905	COG1215	transferase activity, transferring glycosyl groups
BB347_RS16915	COG1215	transferase activity, transferring glycosyl groups
BB347_RS16920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BB347_RS16990	COG0438	transferase activity, transferring glycosyl groups
BB347_RS17030	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BB347_RS17040	COG0673	inositol 2-dehydrogenase activity
BB347_RS17050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BB347_RS17110	COG0589	response to stress
BB347_RS17110	COG0475	glutathione-regulated potassium exporter activity
BB347_RS17115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BB347_RS17160	COG1192	Involved in chromosome partitioning
BB347_RS17175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BB347_RS17210	COG1605	Chorismate mutase
BB347_RS17210	COG0287	Prephenate dehydrogenase
BB347_RS17230	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BB347_RS17235	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BB347_RS17315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BB347_RS17320	COG0651	ATP synthesis coupled electron transport
BB347_RS17325	COG0651	ATP synthesis coupled electron transport
BB347_RS17330	COG1006	Multisubunit Na H antiporter MnhC subunit
BB347_RS17345	COG1320	monovalent cation:proton antiporter activity
BB347_RS17350	COG2212	antiporter activity
BB347_RS17380	COG0167	dihydroorotate dehydrogenase activity
BB347_RS17390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BB347_RS17495	COG0531	amino acid
BB347_RS17510	COG0569	domain protein
BB347_RS17565	COG2217	Heavy metal translocating P-type atpase
BB347_RS17580	COG0348	domain, Protein
BB347_RS17600	COG0798	PFAM Bile acid sodium symporter
BB347_RS17730	COG0438	transferase activity, transferring glycosyl groups
BB347_RS17820	COG0864	Transcriptional regulator
BB347_RS17865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BB347_RS17870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BB347_RS17875	COG0066	3-isopropylmalate dehydratase activity
BB347_RS17880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BB347_RS17885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BB347_RS17895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BB347_RS18265	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BB347_RS18415	COG1404	Belongs to the peptidase S8 family
BB347_RS18445	COG1404	Belongs to the peptidase S8 family
BB347_RS18580	COG1192	Involved in chromosome partitioning
BB347_RS18775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BB347_RS18785	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BB347_RS19030	COG4608	Belongs to the ABC transporter superfamily