locus-tag	class	description
HORE_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HORE_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HORE_RS00030	COG0187	DNA topoisomerase II activity
HORE_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HORE_RS00050	COG0697	spore germination
HORE_RS00055	COG0814	amino acid
HORE_RS00175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HORE_RS00180	COG1120	ATPase activity
HORE_RS00205	COG1011	Hydrolase
HORE_RS00280	COG1175	transmembrane transport
HORE_RS00285	COG0395	ABC-type sugar transport system, permease component
HORE_RS00290	COG1609	Transcriptional regulator
HORE_RS00295	COG1554	hydrolase, family 65, central catalytic
HORE_RS00300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HORE_RS00305	COG1609	Transcriptional regulator
HORE_RS00310	COG3842	ATPase activity
HORE_RS00320	COG0840	transmembrane signaling receptor activity
HORE_RS00335	COG2183	response to ionizing radiation
HORE_RS00340	COG1098	S1 RNA binding domain
HORE_RS00365	COG0037	tRNA processing
HORE_RS00370	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HORE_RS00375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HORE_RS00380	COG4145	pantothenate transmembrane transporter activity
HORE_RS00385	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HORE_RS00395	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HORE_RS00400	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HORE_RS00410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HORE_RS00420	COG1744	ABC transporter substrate-binding protein PnrA-like
HORE_RS00425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HORE_RS00430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HORE_RS00435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HORE_RS00450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HORE_RS00450	COG5322	oxidoreductase activity
HORE_RS00460	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HORE_RS00465	COG0432	Pfam Uncharacterised protein family UPF0047
HORE_RS00470	COG1940	carbohydrate kinase activity
HORE_RS00475	COG1653	transport
HORE_RS00480	COG1175	transmembrane transport
HORE_RS00485	COG0395	ABC-type sugar transport system, permease component
HORE_RS00530	COG3880	PFAM UvrB UvrC protein
HORE_RS00535	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HORE_RS00540	COG0542	response to heat
HORE_RS00545	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HORE_RS00550	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HORE_RS00560	COG4956	integral membrane protein (PIN domain superfamily)
HORE_RS00565	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HORE_RS00570	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HORE_RS00575	COG0517	IMP dehydrogenase activity
HORE_RS00580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HORE_RS00585	COG0215	cysteine-tRNA ligase activity
HORE_RS00600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HORE_RS00610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HORE_RS00615	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HORE_RS00620	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HORE_RS00625	COG0250	Participates in transcription elongation, termination and antitermination
HORE_RS00630	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HORE_RS00635	COG0081	regulation of translation
HORE_RS00645	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HORE_RS00650	COG0222	ribosome binding
HORE_RS00655	COG0085	RNA polymerase activity
HORE_RS00660	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HORE_RS00670	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HORE_RS00675	COG0049	tRNA binding
HORE_RS00680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HORE_RS00685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HORE_RS00695	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HORE_RS00700	COG0088	Forms part of the polypeptide exit tunnel
HORE_RS00705	COG0089	rRNA binding
HORE_RS00710	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HORE_RS00715	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HORE_RS00720	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HORE_RS00725	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HORE_RS00730	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HORE_RS00735	COG0255	Belongs to the universal ribosomal protein uL29 family
HORE_RS00740	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HORE_RS00745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HORE_RS00750	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HORE_RS00755	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HORE_RS00760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HORE_RS00765	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HORE_RS00770	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HORE_RS00775	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HORE_RS00780	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HORE_RS00785	COG0200	Binds to the 23S rRNA
HORE_RS00790	COG0201	protein transport
HORE_RS00795	COG0563	adenylate kinase activity
HORE_RS00810	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HORE_RS00815	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HORE_RS00820	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HORE_RS00825	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HORE_RS00830	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HORE_RS00835	COG0202	RNA polymerase activity
HORE_RS00840	COG0203	ribosomal protein L17
HORE_RS00845	COG1122	ATPase activity
HORE_RS00855	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HORE_RS00860	COG0101	tRNA pseudouridine synthase activity
HORE_RS00865	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HORE_RS00880	COG2078	PFAM AMMECR1 domain protein
HORE_RS00880	COG3885	ferrous iron binding
HORE_RS00885	COG2078	PFAM AMMECR1 domain protein
HORE_RS00885	COG3885	ferrous iron binding
HORE_RS00900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HORE_RS00920	COG0297	glycogen (starch) synthase activity
HORE_RS00925	COG4512	PFAM Accessory gene regulator B
HORE_RS00935	COG3290	protein histidine kinase activity
HORE_RS00940	COG3279	Response regulator of the LytR AlgR family
HORE_RS00950	COG0736	holo-[acyl-carrier-protein] synthase activity
HORE_RS00955	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HORE_RS00955	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HORE_RS00960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HORE_RS00965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HORE_RS00970	COG0717	Belongs to the dCTP deaminase family
HORE_RS00975	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HORE_RS00985	COG2337	Toxic component of a toxin-antitoxin (TA) module
HORE_RS00995	COG1228	amidohydrolase
HORE_RS01030	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HORE_RS01035	COG1396	sequence-specific DNA binding
HORE_RS01070	COG0077	Prephenate dehydratase
HORE_RS01070	COG1605	Chorismate mutase
HORE_RS01075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HORE_RS01080	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HORE_RS01085	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HORE_RS01090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HORE_RS01095	COG0802	atpase or kinase
HORE_RS01100	COG1214	PFAM Peptidase M22, glycoprotease
HORE_RS01105	COG0456	acetyltransferase
HORE_RS01110	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HORE_RS01120	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HORE_RS01125	COG0459	protein refolding
HORE_RS01130	COG0519	Catalyzes the synthesis of GMP from XMP
HORE_RS01130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HORE_RS01135	COG4496	protein, YerC YecD
HORE_RS01145	COG2199	diguanylate cyclase activity
HORE_RS01145	COG2200	EAL domain
HORE_RS01145	COG2203	Gaf domain
HORE_RS01165	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HORE_RS01170	COG1454	alcohol dehydrogenase
HORE_RS01170	COG1012	belongs to the aldehyde dehydrogenase family
HORE_RS01185	COG2339	peptidase activity
HORE_RS01190	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HORE_RS01205	COG0124	histidyl-tRNA synthetase
HORE_RS01210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HORE_RS01215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HORE_RS01220	COG0131	Imidazoleglycerol-phosphate dehydratase
HORE_RS01225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HORE_RS01230	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HORE_RS01235	COG0107	imidazoleglycerol-phosphate synthase activity
HORE_RS01240	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HORE_RS01240	COG0140	phosphoribosyl-ATP diphosphatase activity
HORE_RS01245	COG5577	PFAM Coat F domain
HORE_RS01265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HORE_RS01275	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HORE_RS01280	COG0154	amidase activity
HORE_RS01285	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HORE_RS01325	COG1122	ATPase activity
HORE_RS01335	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HORE_RS01340	COG0101	tRNA pseudouridine synthase activity
HORE_RS01345	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HORE_RS01360	COG3885	ferrous iron binding
HORE_RS01360	COG2078	PFAM AMMECR1 domain protein
HORE_RS01365	COG2078	PFAM AMMECR1 domain protein
HORE_RS01365	COG3885	ferrous iron binding
HORE_RS01380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HORE_RS01395	COG1136	(ABC) transporter
HORE_RS01400	COG0577	efflux transmembrane transporter activity
HORE_RS01405	COG1136	(ABC) transporter
HORE_RS01405	COG0577	efflux transmembrane transporter activity
HORE_RS01415	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HORE_RS01440	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HORE_RS01445	COG0667	Aldo Keto reductase
HORE_RS01450	COG1652	LysM domain
HORE_RS01450	COG2823	Periplasmic or secreted lipoprotein
HORE_RS01460	COG1321	iron dependent repressor
HORE_RS01465	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HORE_RS01470	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HORE_RS01490	COG0640	Transcriptional regulator
HORE_RS01510	COG1131	(ABC) transporter
HORE_RS01525	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HORE_RS01530	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HORE_RS01535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HORE_RS01540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HORE_RS01560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HORE_RS01565	COG0137	argininosuccinate synthase activity
HORE_RS01575	COG0165	Argininosuccinate lyase
HORE_RS01595	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HORE_RS01600	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HORE_RS01610	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HORE_RS01625	COG0840	transmembrane signaling receptor activity
HORE_RS01640	COG1683	Conserved Protein
HORE_RS01650	COG2959	enzyme of heme biosynthesis
HORE_RS01655	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
HORE_RS01665	COG3679	Belongs to the UPF0342 family
HORE_RS01670	COG0316	Belongs to the HesB IscA family
HORE_RS01670	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HORE_RS01690	COG1027	Aspartate ammonia-lyase
HORE_RS01705	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HORE_RS01710	COG0825	malonyl-CoA metabolic process
HORE_RS01715	COG0205	6-phosphofructokinase activity
HORE_RS01725	COG1349	DNA-binding transcription factor activity
HORE_RS01730	COG1063	alcohol dehydrogenase
HORE_RS01735	COG2376	Dihydroxyacetone kinase
HORE_RS01745	COG0698	ribose 5-phosphate isomerase
HORE_RS01750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HORE_RS01755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HORE_RS01765	COG0395	ABC-type sugar transport system, permease component
HORE_RS01770	COG3842	ATPase activity
HORE_RS01775	COG3842	ATPase activity
HORE_RS01780	COG1653	transport
HORE_RS01790	COG0011	TIGRFAM Protein of
HORE_RS01800	COG1361	Conserved repeat domain
HORE_RS01810	COG1067	ATP-dependent peptidase activity
HORE_RS01820	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HORE_RS01830	COG1793	dna ligase
HORE_RS01890	COG0740	serine-type endopeptidase activity
HORE_RS01945	COG0582	viral genome integration into host DNA
HORE_RS01970	COG1501	Belongs to the glycosyl hydrolase 31 family
HORE_RS01980	COG0798	PFAM Bile acid sodium symporter
HORE_RS02010	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HORE_RS02015	COG1138	Cytochrome C-type biogenesis protein
HORE_RS02020	COG1126	abc transporter atp-binding protein
HORE_RS02030	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HORE_RS02035	COG0805	protein transport
HORE_RS02045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HORE_RS02070	COG0375	protein maturation
HORE_RS02075	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HORE_RS02080	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HORE_RS02085	COG0298	carbon dioxide binding
HORE_RS02110	COG0667	Aldo Keto reductase
HORE_RS02145	COG0420	3'-5' exonuclease activity
HORE_RS02150	COG0419	ATPase involved in DNA repair
HORE_RS02170	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HORE_RS02175	COG2188	Transcriptional regulator
HORE_RS02185	COG2059	Chromate
HORE_RS02195	COG0351	phosphomethylpyrimidine kinase
HORE_RS02200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HORE_RS02200	COG0731	radical SAM domain protein
HORE_RS02215	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HORE_RS02240	COG1609	Transcriptional regulator
HORE_RS02270	COG1609	Transcriptional regulator
HORE_RS02285	COG1175	transmembrane transport
HORE_RS02295	COG0840	transmembrane signaling receptor activity
HORE_RS02305	COG0535	radical SAM domain protein
HORE_RS02330	COG1307	EDD domain protein, DegV family
HORE_RS02335	COG1309	transcriptional regulator
HORE_RS02345	COG0641	radical SAM
HORE_RS02365	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HORE_RS02375	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HORE_RS02400	COG2188	Transcriptional regulator
HORE_RS02405	COG1131	(ABC) transporter
HORE_RS02425	COG0537	adenosine 5'-monophosphoramidase activity
HORE_RS02430	COG1609	Transcriptional regulator
HORE_RS02435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HORE_RS02475	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HORE_RS02480	COG3052	prosthetic group binding
HORE_RS02490	COG3051	citrate lyase alpha subunit
HORE_RS02500	COG0745	RESPONSE REGULATOR receiver
HORE_RS02505	COG2205	protein histidine kinase activity
HORE_RS02545	COG0840	transmembrane signaling receptor activity
HORE_RS02550	COG2814	Major facilitator Superfamily
HORE_RS02555	COG2723	6-phospho-beta-galactosidase activity
HORE_RS02570	COG2217	Heavy metal translocating P-type atpase
HORE_RS02575	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HORE_RS02575	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HORE_RS02580	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HORE_RS02585	COG1971	Probably functions as a manganese efflux pump
HORE_RS02590	COG0237	dephospho-CoA kinase activity
HORE_RS02595	COG4166	transmembrane transport
HORE_RS02600	COG0601	transmembrane transport
HORE_RS02605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HORE_RS02610	COG0444	Belongs to the ABC transporter superfamily
HORE_RS02615	COG4608	Belongs to the ABC transporter superfamily
HORE_RS02630	COG2252	PERMEase
HORE_RS02680	COG1918	ferrous iron import across plasma membrane
HORE_RS02680	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HORE_RS02685	COG0095	Lipoate-protein ligase
HORE_RS02695	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HORE_RS02710	COG3949	Membrane
HORE_RS02715	COG2340	Cysteine-rich secretory protein family
HORE_RS02725	COG1268	BioY protein
HORE_RS02740	COG0534	Mate efflux family protein
HORE_RS02745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HORE_RS02770	COG1307	EDD domain protein, DegV family
HORE_RS02785	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HORE_RS02785	COG0674	pyruvate-flavodoxin oxidoreductase activity
HORE_RS02790	COG1013	pyruvate-flavodoxin oxidoreductase activity
HORE_RS02800	COG2033	superoxide reductase activity
HORE_RS02815	COG2323	membrane
HORE_RS02835	COG1309	transcriptional regulator
HORE_RS02840	COG5577	PFAM Coat F domain
HORE_RS02850	COG1278	Cold shock
HORE_RS02860	COG4145	pantothenate transmembrane transporter activity
HORE_RS02870	COG2323	membrane
HORE_RS02875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HORE_RS02880	COG0583	DNA-binding transcription factor activity
HORE_RS02885	COG2855	membrane
HORE_RS02895	COG0513	Belongs to the DEAD box helicase family
HORE_RS02985	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HORE_RS02990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HORE_RS02995	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HORE_RS03000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HORE_RS03005	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HORE_RS03010	COG0072	phenylalanine-tRNA ligase activity
HORE_RS03010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HORE_RS03025	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HORE_RS03025	COG1796	DNA polymerase
HORE_RS03030	COG1193	negative regulation of DNA recombination
HORE_RS03035	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HORE_RS03040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HORE_RS03060	COG0628	permease
HORE_RS03065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HORE_RS03070	COG4472	Bacterial protein of unknown function (DUF965)
HORE_RS03090	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HORE_RS03100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HORE_RS03105	COG4122	O-methyltransferase activity
HORE_RS03110	COG0826	peptidase U32
HORE_RS03125	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HORE_RS03135	COG2002	toxin-antitoxin pair type II binding
HORE_RS03140	COG0735	belongs to the Fur family
HORE_RS03145	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HORE_RS03160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HORE_RS03170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HORE_RS03175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HORE_RS03185	COG1459	type II secretion system
HORE_RS03195	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HORE_RS03235	COG1450	Type ii and iii secretion system protein
HORE_RS03240	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HORE_RS03245	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HORE_RS03250	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HORE_RS03255	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HORE_RS03260	COG0006	proline dipeptidase activity
HORE_RS03265	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HORE_RS03270	COG1489	DNA binding
HORE_RS03275	COG3854	ATPases associated with a variety of cellular activities
HORE_RS03315	COG0511	ligase activity, forming carbon-carbon bonds
HORE_RS03320	COG0439	Biotin carboxylase
HORE_RS03325	COG1302	Protein conserved in bacteria
HORE_RS03340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HORE_RS03360	COG0517	IMP dehydrogenase activity
HORE_RS03375	COG2002	toxin-antitoxin pair type II binding
HORE_RS03420	COG2989	Protein conserved in bacteria
HORE_RS03445	COG0493	'glutamate synthase
HORE_RS03445	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HORE_RS03450	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HORE_RS03455	COG1570	exodeoxyribonuclease VII activity
HORE_RS03480	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HORE_RS03485	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HORE_RS03490	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HORE_RS03495	COG1438	arginine binding
HORE_RS03500	COG0497	DNA recombination
HORE_RS03505	COG0750	zinc metalloprotease
HORE_RS03510	COG0745	RESPONSE REGULATOR receiver
HORE_RS03525	COG0463	Glycosyl transferase, family 2
HORE_RS03540	COG2235	arginine
HORE_RS03545	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HORE_RS03555	COG0549	Belongs to the carbamate kinase family
HORE_RS03575	COG3829	transcription factor binding
HORE_RS03575	COG3290	protein histidine kinase activity
HORE_RS03585	COG0280	phosphate acetyltransferase
HORE_RS03595	COG3426	butyrate kinase activity
HORE_RS03605	COG0674	pyruvate-flavodoxin oxidoreductase activity
HORE_RS03620	COG2195	Cleaves the N-terminal amino acid of tripeptides
HORE_RS03630	COG0494	nUDIX hydrolase
HORE_RS03635	COG1379	DNA repair
HORE_RS03645	COG1300	Membrane
HORE_RS03665	COG0297	glycogen (starch) synthase activity
HORE_RS03670	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HORE_RS03675	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HORE_RS03680	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HORE_RS03685	COG0297	glycogen (starch) synthase activity
HORE_RS03695	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HORE_RS03705	COG1686	Belongs to the peptidase S11 family
HORE_RS03720	COG2172	sigma factor antagonist activity
HORE_RS03740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HORE_RS03750	COG0697	spore germination
HORE_RS03765	COG1924	4 iron, 4 sulfur cluster binding
HORE_RS03780	COG0019	diaminopimelate decarboxylase activity
HORE_RS03785	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HORE_RS03785	COG3620	sequence-specific DNA binding
HORE_RS03785	COG0617	tRNA 3'-terminal CCA addition
HORE_RS03790	COG1994	Peptidase M50
HORE_RS03795	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HORE_RS03800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HORE_RS03810	COG3874	Sporulation protein YtfJ
HORE_RS03815	COG2431	L-lysine efflux transmembrane transporter activity
HORE_RS03820	COG1686	Belongs to the peptidase S11 family
HORE_RS03825	COG1187	pseudouridine synthase activity
HORE_RS03830	COG2359	stage V sporulation protein S
HORE_RS03835	COG1196	nuclear chromosome segregation
HORE_RS03845	COG0552	protein localization to endoplasmic reticulum
HORE_RS03850	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HORE_RS03855	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HORE_RS03860	COG0228	four-way junction DNA binding
HORE_RS03870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HORE_RS03875	COG0336	Belongs to the RNA methyltransferase TrmD family
HORE_RS03880	COG4752	Belongs to the RNA methyltransferase TrmD family
HORE_RS03885	COG0335	large ribosomal subunit rRNA binding
HORE_RS03895	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HORE_RS03910	COG0792	nuclease activity
HORE_RS03915	COG0606	chelatase, subunit chli
HORE_RS03960	COG0667	Aldo Keto reductase
HORE_RS03970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HORE_RS03970	COG0758	DNA mediated transformation
HORE_RS03975	COG2922	Belongs to the Smg family
HORE_RS03980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HORE_RS03985	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HORE_RS03990	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HORE_RS03995	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HORE_RS04005	COG2201	protein-glutamate methylesterase activity
HORE_RS04010	COG2198	Histidine kinase
HORE_RS04010	COG0643	Histidine kinase
HORE_RS04015	COG0835	chemotaxis
HORE_RS04025	COG1776	CheC inhibitor of MCP methylation
HORE_RS04030	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HORE_RS04035	COG0052	Belongs to the universal ribosomal protein uS2 family
HORE_RS04040	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HORE_RS04045	COG0528	UMP kinase activity
HORE_RS04050	COG0233	cytoplasmic translational termination
HORE_RS04060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HORE_RS04065	COG4589	Belongs to the CDS family
HORE_RS04070	COG0628	permease
HORE_RS04075	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HORE_RS04080	COG0750	zinc metalloprotease
HORE_RS04085	COG1418	mRNA catabolic process
HORE_RS04090	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HORE_RS04095	COG0442	prolyl-tRNA aminoacylation
HORE_RS04115	COG0779	Required for maturation of 30S ribosomal subunits
HORE_RS04120	COG0195	Participates in both transcription termination and antitermination
HORE_RS04130	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HORE_RS04135	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HORE_RS04145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HORE_RS04150	COG0196	riboflavin kinase activity
HORE_RS04155	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HORE_RS04160	COG1185	polyribonucleotide nucleotidyltransferase activity
HORE_RS04165	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HORE_RS04170	COG1199	ATP-dependent helicase activity
HORE_RS04170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HORE_RS04190	COG0726	polysaccharide deacetylase
HORE_RS04195	COG0756	dUTP diphosphatase activity
HORE_RS04200	COG1873	PFAM PRC-barrel domain
HORE_RS04215	COG0083	homoserine kinase activity
HORE_RS04225	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HORE_RS04230	COG0527	aspartate kinase activity
HORE_RS04235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HORE_RS04240	COG0473	3-isopropylmalate dehydrogenase activity
HORE_RS04250	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HORE_RS04255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HORE_RS04265	COG0446	pyridine nucleotide-disulphide oxidoreductase
HORE_RS04285	COG0445	tRNA wobble uridine modification
HORE_RS04295	COG1164	Oligoendopeptidase f
HORE_RS04305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HORE_RS04315	COG0018	arginyl-trna synthetase
HORE_RS04320	COG0028	Belongs to the TPP enzyme family
HORE_RS04330	COG1671	Belongs to the UPF0178 family
HORE_RS04335	COG0622	Phosphoesterase
HORE_RS04350	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HORE_RS04355	COG0564	pseudouridine synthase activity
HORE_RS04420	COG1254	Belongs to the acylphosphatase family
HORE_RS04430	COG1309	transcriptional regulator
HORE_RS04435	COG2409	Drug exporters of the RND superfamily
HORE_RS04475	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HORE_RS04475	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HORE_RS04480	COG0307	riboflavin synthase, alpha
HORE_RS04485	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HORE_RS04485	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HORE_RS04490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HORE_RS04495	COG1131	(ABC) transporter
HORE_RS04510	COG0116	Belongs to the methyltransferase superfamily
HORE_RS04520	COG0697	spore germination
HORE_RS04530	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HORE_RS04535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HORE_RS04540	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HORE_RS04545	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HORE_RS04550	COG0527	aspartate kinase activity
HORE_RS04555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HORE_RS04560	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HORE_RS04565	COG0740	serine-type endopeptidase activity
HORE_RS04580	COG1968	undecaprenyl-diphosphatase activity
HORE_RS04585	COG1674	ftsk spoiiie
HORE_RS04590	COG2188	Transcriptional regulator
HORE_RS04595	COG3845	ABC transporter
HORE_RS04600	COG4603	Belongs to the binding-protein-dependent transport system permease family
HORE_RS04605	COG1079	Belongs to the binding-protein-dependent transport system permease family
HORE_RS04615	COG1426	Protein conserved in bacteria
HORE_RS04635	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HORE_RS04645	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HORE_RS04655	COG1959	2 iron, 2 sulfur cluster binding
HORE_RS04660	COG1104	cysteine desulfurase activity
HORE_RS04665	COG0822	iron-sulfur transferase activity
HORE_RS04670	COG0482	sulfurtransferase activity
HORE_RS04725	COG0735	belongs to the Fur family
HORE_RS04730	COG0180	Tryptophanyl-tRNA synthetase
HORE_RS04735	COG1181	Belongs to the D-alanine--D-alanine ligase family
HORE_RS04740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HORE_RS04745	COG2001	Belongs to the MraZ family
HORE_RS04750	COG0275	rRNA processing
HORE_RS04760	COG0768	penicillin binding
HORE_RS04765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HORE_RS04770	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HORE_RS04775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HORE_RS04780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HORE_RS04785	COG0772	Belongs to the SEDS family
HORE_RS04790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HORE_RS04795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HORE_RS04810	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HORE_RS04820	COG1191	sigma factor activity
HORE_RS04825	COG1191	sigma factor activity
HORE_RS04835	COG1873	PFAM PRC-barrel domain
HORE_RS04840	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HORE_RS04855	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HORE_RS04860	COG1799	cell septum assembly
HORE_RS04870	COG2302	S4 RNA-binding domain
HORE_RS04875	COG3599	regulation of cell shape
HORE_RS04880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HORE_RS04885	COG0534	Mate efflux family protein
HORE_RS04895	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HORE_RS04900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HORE_RS04905	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HORE_RS04910	COG0564	pseudouridine synthase activity
HORE_RS04920	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HORE_RS04925	COG2233	PERMEase
HORE_RS04930	COG0540	Belongs to the ATCase OTCase family
HORE_RS04935	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HORE_RS04940	COG0284	orotidine-5'-phosphate decarboxylase activity
HORE_RS04950	COG0543	2 iron, 2 sulfur cluster binding
HORE_RS04955	COG0167	dihydroorotate dehydrogenase activity
HORE_RS04960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HORE_RS04965	COG1609	Transcriptional regulator
HORE_RS04975	COG0366	Alpha amylase catalytic
HORE_RS04985	COG1501	Belongs to the glycosyl hydrolase 31 family
HORE_RS05015	COG1879	ABC-type sugar transport system periplasmic component
HORE_RS05020	COG1129	ABC transporter
HORE_RS05025	COG1172	Belongs to the binding-protein-dependent transport system permease family
HORE_RS05045	COG1070	Carbohydrate kinase
HORE_RS05065	COG2195	Cleaves the N-terminal amino acid of tripeptides
HORE_RS05070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HORE_RS05080	COG2373	Large extracellular alpha-helical protein
HORE_RS05085	COG4953	penicillin-binding protein 1C
HORE_RS05095	COG4294	response to UV
HORE_RS05100	COG0366	Alpha amylase catalytic
HORE_RS05135	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HORE_RS05140	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HORE_RS05145	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HORE_RS05150	COG2052	Domain of unknown function (DUF370)
HORE_RS05155	COG0194	GDP metabolic process
HORE_RS05160	COG1758	RNA polymerase activity
HORE_RS05165	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HORE_RS05175	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HORE_RS05185	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HORE_RS05195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HORE_RS05200	COG0242	peptide deformylase activity
HORE_RS05205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HORE_RS05210	COG2738	Putative neutral zinc metallopeptidase
HORE_RS05220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HORE_RS05220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HORE_RS05225	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HORE_RS05230	COG0631	protein serine/threonine phosphatase activity
HORE_RS05235	COG2815	serine threonine protein kinase
HORE_RS05235	COG0515	serine threonine protein kinase
HORE_RS05245	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HORE_RS05250	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HORE_RS05250	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HORE_RS05255	COG0307	riboflavin synthase, alpha
HORE_RS05260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HORE_RS05260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HORE_RS05265	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HORE_RS05270	COG3859	Proton-coupled thiamine transporter YuaJ
HORE_RS05285	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HORE_RS05295	COG0281	malic enzyme
HORE_RS05300	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HORE_RS05305	COG1302	Protein conserved in bacteria
HORE_RS05310	COG1461	Dihydroxyacetone kinase
HORE_RS05315	COG1307	EDD domain protein, DegV family
HORE_RS05320	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HORE_RS05325	COG0742	ribosomal rna small subunit methyltransferase
HORE_RS05330	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HORE_RS05335	COG3314	Sporulation integral membrane protein YlbJ
HORE_RS05340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HORE_RS05345	COG1752	Esterase of the alpha-beta hydrolase superfamily
HORE_RS05350	COG3480	Lon protease (S16) C-terminal proteolytic domain
HORE_RS05355	COG1323	Belongs to the UPF0348 family
HORE_RS05360	COG0280	phosphate acetyltransferase
HORE_RS05365	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HORE_RS05375	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HORE_RS05385	COG0416	fatty acid biosynthetic process
HORE_RS05390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HORE_RS05395	COG2070	2-Nitropropane dioxygenase
HORE_RS05400	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HORE_RS05405	COG1028	Short-chain dehydrogenase reductase Sdr
HORE_RS05410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HORE_RS05415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HORE_RS05430	COG4401	Chorismate mutase type I
HORE_RS05435	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HORE_RS05440	COG0287	Prephenate dehydrogenase
HORE_RS05445	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HORE_RS05455	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HORE_RS05460	COG0204	Acyl-transferase
HORE_RS05465	COG3275	phosphorelay sensor kinase activity
HORE_RS05470	COG3279	Response regulator of the LytR AlgR family
HORE_RS05475	COG1966	Carbon starvation protein
HORE_RS05480	COG2703	oxygen carrier activity
HORE_RS05525	COG1160	GTP binding
HORE_RS05530	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HORE_RS05535	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HORE_RS05540	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HORE_RS05570	COG2201	protein-glutamate methylesterase activity
HORE_RS05575	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HORE_RS05585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HORE_RS05595	COG0402	S-adenosylhomocysteine deaminase activity
HORE_RS05600	COG2003	Belongs to the UPF0758 family
HORE_RS05610	COG1615	UPF0182 protein
HORE_RS05615	COG0612	Peptidase, M16
HORE_RS05620	COG0612	Peptidase, M16
HORE_RS05630	COG2211	Major facilitator Superfamily
HORE_RS05635	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HORE_RS05650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HORE_RS05660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HORE_RS05665	COG0129	dihydroxy-acid dehydratase activity
HORE_RS05670	COG0028	Belongs to the TPP enzyme family
HORE_RS05675	COG0440	acetolactate synthase activity
HORE_RS05680	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HORE_RS05685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HORE_RS05690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HORE_RS05695	COG0066	3-isopropylmalate dehydratase activity
HORE_RS05700	COG0473	3-isopropylmalate dehydrogenase activity
HORE_RS05705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HORE_RS05710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HORE_RS05720	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HORE_RS05730	COG2385	sporulation resulting in formation of a cellular spore
HORE_RS05740	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HORE_RS05745	COG0739	heme binding
HORE_RS05755	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HORE_RS05755	COG0321	lipoyl(octanoyl) transferase activity
HORE_RS05760	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HORE_RS05785	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HORE_RS05785	COG0731	radical SAM domain protein
HORE_RS05810	COG4974	Belongs to the 'phage' integrase family
HORE_RS05835	COG1297	OPT oligopeptide transporter protein
HORE_RS05840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HORE_RS05845	COG0671	phosphoesterase, PA-phosphatase related
HORE_RS05860	COG0778	Nitroreductase
HORE_RS05905	COG2839	Protein conserved in bacteria
HORE_RS05925	COG0133	tryptophan synthase activity
HORE_RS05930	COG3584	3D domain protein
HORE_RS05930	COG1388	LysM domain
HORE_RS05935	COG1331	Highly conserved protein containing a thioredoxin domain
HORE_RS06000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HORE_RS06005	COG1388	LysM domain
HORE_RS06005	COG3942	CHAP domain
HORE_RS06010	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HORE_RS06015	COG1573	uracil-dna glycosylase
HORE_RS06020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HORE_RS06025	COG1116	anion transmembrane transporter activity
HORE_RS06030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HORE_RS06040	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HORE_RS06045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HORE_RS06055	COG0436	Aminotransferase
HORE_RS06060	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HORE_RS06065	COG1923	regulation of RNA biosynthetic process
HORE_RS06080	COG0464	growth
HORE_RS06095	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HORE_RS06100	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HORE_RS06105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HORE_RS06110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HORE_RS06115	COG0569	domain protein
HORE_RS06120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HORE_RS06125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HORE_RS06130	COG0038	chloride channel
HORE_RS06135	COG0187	DNA topoisomerase II activity
HORE_RS06140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HORE_RS06145	COG3773	Cell wall hydrolase
HORE_RS06145	COG3409	Peptidoglycan-binding domain 1 protein
HORE_RS06170	COG0811	peptide transport
HORE_RS06175	COG0613	PHP domain protein
HORE_RS06180	COG0700	Nucleoside recognition
HORE_RS06185	COG2715	membrane protein required for spore maturation
HORE_RS06190	COG2359	stage V sporulation protein S
HORE_RS06195	COG1418	mRNA catabolic process
HORE_RS06200	COG2137	regulation of response to DNA damage stimulus
HORE_RS06205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HORE_RS06210	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HORE_RS06220	COG1546	Belongs to the CinA family
HORE_RS06220	COG1058	Belongs to the CinA family
HORE_RS06225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HORE_RS06235	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HORE_RS06240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HORE_RS06245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HORE_RS06270	COG1242	4 iron, 4 sulfur cluster binding
HORE_RS06275	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HORE_RS06285	COG1739	Uncharacterized protein family UPF0029
HORE_RS06295	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HORE_RS06300	COG0651	ATP synthesis coupled electron transport
HORE_RS06305	COG0651	ATP synthesis coupled electron transport
HORE_RS06310	COG1006	Multisubunit Na H antiporter MnhC subunit
HORE_RS06325	COG1320	monovalent cation:proton antiporter activity
HORE_RS06330	COG2212	antiporter activity
HORE_RS06335	COG1863	multisubunit Na H antiporter MnhE subunit
HORE_RS06345	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HORE_RS06350	COG0124	histidyl-tRNA synthetase
HORE_RS06360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HORE_RS06365	COG1490	D-aminoacyl-tRNA deacylase activity
HORE_RS06370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HORE_RS06375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HORE_RS06380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HORE_RS06380	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HORE_RS06400	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HORE_RS06405	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HORE_RS06415	COG1862	Preprotein translocase
HORE_RS06420	COG0343	queuine tRNA-ribosyltransferase activity
HORE_RS06425	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HORE_RS06430	COG2255	four-way junction helicase activity
HORE_RS06435	COG0632	four-way junction helicase activity
HORE_RS06440	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HORE_RS06450	COG0217	transcriptional regulatory protein
HORE_RS06475	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HORE_RS06485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HORE_RS06490	COG0358	DNA primase activity
HORE_RS06495	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HORE_RS06500	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HORE_RS06505	COG0751	glycine-tRNA ligase activity
HORE_RS06510	COG0752	glycyl-tRNA synthetase alpha subunit
HORE_RS06520	COG1381	Involved in DNA repair and RecF pathway recombination
HORE_RS06525	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HORE_RS06530	COG2239	Acts as a magnesium transporter
HORE_RS06535	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HORE_RS06540	COG0295	cytidine deaminase activity
HORE_RS06560	COG4536	flavin adenine dinucleotide binding
HORE_RS06565	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HORE_RS06570	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HORE_RS06575	COG1480	7TM receptor with intracellular HD hydrolase
HORE_RS06580	COG1702	phosphate starvation-inducible protein PhoH
HORE_RS06595	COG2323	membrane
HORE_RS06630	COG1494	fructose-1,6-bisphosphatase
HORE_RS06635	COG0517	IMP dehydrogenase activity
HORE_RS06645	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HORE_RS06650	COG1610	YqeY-like protein
HORE_RS06655	COG0537	adenosine 5'-monophosphoramidase activity
HORE_RS06660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HORE_RS06665	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HORE_RS06670	COG2264	protein methyltransferase activity
HORE_RS06675	COG0484	heat shock protein binding
HORE_RS06680	COG0443	Heat shock 70 kDa protein
HORE_RS06685	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HORE_RS06690	COG1420	regulation of RNA biosynthetic process
HORE_RS06695	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HORE_RS06700	COG0481	GTPase activity
HORE_RS06710	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HORE_RS06720	COG0268	Binds directly to 16S ribosomal RNA
HORE_RS06725	COG1466	dna polymerase III delta subunit
HORE_RS06745	COG1555	photosystem II stabilization
HORE_RS06745	COG1596	polysaccharide export
HORE_RS06760	COG0450	alkyl hydroperoxide reductase
HORE_RS06765	COG0572	uridine kinase
HORE_RS06785	COG1131	(ABC) transporter
HORE_RS06800	COG4608	Belongs to the ABC transporter superfamily
HORE_RS06805	COG0444	Belongs to the ABC transporter superfamily
HORE_RS06810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HORE_RS06815	COG0601	transmembrane transport
HORE_RS06825	COG1063	alcohol dehydrogenase
HORE_RS06835	COG0395	ABC-type sugar transport system, permease component
HORE_RS06840	COG1175	transmembrane transport
HORE_RS06850	COG1609	Transcriptional regulator
HORE_RS06855	COG0584	glycerophosphoryl diester phosphodiesterase
HORE_RS06865	COG0395	ABC-type sugar transport system, permease component
HORE_RS06870	COG1175	transmembrane transport
HORE_RS06875	COG1653	transport
HORE_RS06895	COG2135	peptidase activity
HORE_RS06900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HORE_RS06915	COG0745	RESPONSE REGULATOR receiver
HORE_RS06920	COG5002	protein histidine kinase activity
HORE_RS06935	COG1937	Protein conserved in bacteria
HORE_RS06960	COG0495	leucyl-tRNA aminoacylation
HORE_RS06965	COG0799	negative regulation of ribosome biogenesis
HORE_RS06970	COG1316	TRANSCRIPTIONal
HORE_RS06975	COG1713	HD superfamily hydrolase involved in NAD metabolism
HORE_RS07035	COG0456	acetyltransferase
HORE_RS07070	COG1032	radical SAM domain protein
HORE_RS07235	COG1523	belongs to the glycosyl hydrolase 13 family
HORE_RS07240	COG3858	chitin binding
HORE_RS07240	COG1388	LysM domain
HORE_RS07260	COG0288	reversible hydration of carbon dioxide
HORE_RS07285	COG1051	belongs to the nudix hydrolase family
HORE_RS07335	COG0488	(ABC) transporter
HORE_RS07340	COG1307	EDD domain protein, DegV family
HORE_RS07350	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HORE_RS07355	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HORE_RS07365	COG1530	ribonuclease E activity
HORE_RS07375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HORE_RS07385	COG0772	Belongs to the SEDS family
HORE_RS07390	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HORE_RS07395	COG2894	cell division
HORE_RS07400	COG0850	regulation of cytokinetic process
HORE_RS07405	COG0768	penicillin binding
HORE_RS07415	COG1792	Involved in formation and maintenance of cell shape
HORE_RS07420	COG1077	Cell shape determining protein MreB Mrl
HORE_RS07425	COG2003	Belongs to the UPF0758 family
HORE_RS07430	COG0424	maF-like protein
HORE_RS07440	COG1477	protein flavinylation
HORE_RS07450	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
HORE_RS07450	COG2878	Part of a membrane complex involved in electron transport
HORE_RS07460	COG4660	Part of a membrane complex involved in electron transport
HORE_RS07465	COG4659	FMN binding
HORE_RS07470	COG4658	electron transport chain
HORE_RS07475	COG4656	Part of a membrane complex involved in electron transport
HORE_RS07485	COG0285	dihydrofolate synthase activity
HORE_RS07495	COG0617	tRNA 3'-terminal CCA addition
HORE_RS07500	COG0849	cell division
HORE_RS07505	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HORE_RS07510	COG0275	rRNA processing
HORE_RS07515	COG2848	UPF0210 protein
HORE_RS07520	COG3830	Belongs to the UPF0237 family
HORE_RS07525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HORE_RS07530	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HORE_RS07540	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HORE_RS07545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HORE_RS07560	COG0840	transmembrane signaling receptor activity
HORE_RS07565	COG0395	ABC-type sugar transport system, permease component
HORE_RS07570	COG1175	transmembrane transport
HORE_RS07575	COG1653	transport
HORE_RS07585	COG1575	Belongs to the MenA family. Type 1 subfamily
HORE_RS07590	COG0521	Mo-molybdopterin cofactor biosynthetic process
HORE_RS07595	COG0525	valine-tRNA ligase activity
HORE_RS07600	COG3290	protein histidine kinase activity
HORE_RS07605	COG0071	Belongs to the small heat shock protein (HSP20) family
HORE_RS07610	COG3359	exonuclease
HORE_RS07615	COG1205	dead DEAH box helicase
HORE_RS07615	COG1111	helicase
HORE_RS07620	COG0330	HflC and HflK could
HORE_RS07635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HORE_RS07675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HORE_RS07680	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HORE_RS07690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HORE_RS07695	COG0826	peptidase U32
HORE_RS07700	COG0163	prenyltransferase activity
HORE_RS07705	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HORE_RS07710	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HORE_RS07720	COG1477	protein flavinylation
HORE_RS07730	COG1252	NADH dehydrogenase
HORE_RS07750	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HORE_RS07755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HORE_RS07760	COG1067	ATP-dependent peptidase activity
HORE_RS07760	COG0470	DNA polymerase III
HORE_RS07765	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HORE_RS07770	COG0740	serine-type endopeptidase activity
HORE_RS07775	COG0544	peptidyl-prolyl cis-trans isomerase activity
HORE_RS07800	COG0463	Glycosyl transferase, family 2
HORE_RS07810	COG0383	alpha-mannosidase activity
HORE_RS07825	COG3833	ABC-type maltose transport systems, permease component
HORE_RS07845	COG2814	Major facilitator Superfamily
HORE_RS07870	COG1098	S1 RNA binding domain
HORE_RS07950	COG2378	regulation of single-species biofilm formation
HORE_RS07955	COG3679	Belongs to the UPF0342 family
HORE_RS07960	COG2723	6-phospho-beta-galactosidase activity
HORE_RS07975	COG1131	(ABC) transporter
HORE_RS07985	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HORE_RS08000	COG5012	cobalamin binding
HORE_RS08030	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HORE_RS08035	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HORE_RS08055	COG3799	methylaspartate ammonia-lyase activity
HORE_RS08060	COG4865	methylaspartate mutase activity
HORE_RS08070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HORE_RS08075	COG2188	Transcriptional regulator
HORE_RS08105	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HORE_RS08110	COG1728	Protein conserved in bacteria
HORE_RS08115	COG0395	ABC-type sugar transport system, permease component
HORE_RS08140	COG1550	Protein conserved in bacteria
HORE_RS08145	COG1773	rubredoxin
HORE_RS08145	COG1592	Rubrerythrin
HORE_RS08155	COG1132	(ABC) transporter
HORE_RS08160	COG0390	transport system, permease component
HORE_RS08210	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HORE_RS08215	COG0557	exoribonuclease II activity
HORE_RS08230	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HORE_RS08235	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HORE_RS08240	COG0148	phosphopyruvate hydratase activity
HORE_RS08245	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HORE_RS08250	COG0149	triose-phosphate isomerase activity
HORE_RS08255	COG0126	phosphoglycerate kinase activity
HORE_RS08270	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HORE_RS08275	COG1481	regulation of sporulation
HORE_RS08280	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HORE_RS08285	COG1660	Displays ATPase and GTPase activities
HORE_RS08290	COG1597	lipid kinase activity
HORE_RS08305	COG1562	ergosterol biosynthetic process
HORE_RS08330	COG1659	Linocin_M18 bacteriocin protein
HORE_RS08335	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HORE_RS08345	COG1543	Belongs to the glycosyl hydrolase 57 family
HORE_RS08365	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HORE_RS08370	COG1940	carbohydrate kinase activity
HORE_RS08405	COG0561	phosphatase activity
HORE_RS08410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HORE_RS08420	COG2221	Nitrite and sulphite reductase 4Fe-4S
HORE_RS08425	COG0366	Alpha amylase catalytic
HORE_RS08430	COG3833	ABC-type maltose transport systems, permease component
HORE_RS08435	COG1175	transmembrane transport
HORE_RS08440	COG2182	Extracellular solute-binding protein
HORE_RS08445	COG1609	Transcriptional regulator
HORE_RS08450	COG0322	excinuclease ABC activity
HORE_RS08460	COG0556	nucleotide-excision repair
HORE_RS08465	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HORE_RS08475	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HORE_RS08480	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HORE_RS08485	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HORE_RS08495	COG0069	glutamate synthase activity
HORE_RS08500	COG0067	glutamate synthase
HORE_RS08505	COG1414	Transcriptional regulator
HORE_RS08510	COG1760	l-serine dehydratase
HORE_RS08515	COG1760	l-serine dehydratase
HORE_RS08520	COG0793	Belongs to the peptidase S41A family
HORE_RS08535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HORE_RS08560	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HORE_RS08565	COG0653	protein targeting
HORE_RS08580	COG1278	Cold shock
HORE_RS08585	COG1040	competence protein
HORE_RS08590	COG1595	DNA-templated transcription, initiation
HORE_RS08620	COG1706	bacterial-type flagellum-dependent cell motility
HORE_RS08625	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HORE_RS08640	COG4786	Flagellar basal body rod
HORE_RS08665	COG1191	sigma factor activity
HORE_RS08685	COG1419	protein localization to endoplasmic reticulum
HORE_RS08690	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HORE_RS08695	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HORE_RS08700	COG1684	flagellar biosynthetic protein fliR
HORE_RS08705	COG1987	bacterial-type flagellum assembly
HORE_RS08710	COG1338	Plays a role in the flagellum-specific transport system
HORE_RS08720	COG1776	CheC inhibitor of MCP methylation
HORE_RS08720	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HORE_RS08725	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HORE_RS08730	COG1580	Controls the rotational direction of flagella during chemotaxis
HORE_RS08760	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HORE_RS08780	COG1157	protein secretion by the type III secretion system
HORE_RS08795	COG1766	The M ring may be actively involved in energy transduction
HORE_RS08800	COG1677	Flagellar hook-basal body complex protein FliE
HORE_RS08805	COG1558	bacterial-type flagellum-dependent cell motility
HORE_RS08810	COG1815	bacterial-type flagellum-dependent cell motility
HORE_RS08815	COG2201	protein-glutamate methylesterase activity
HORE_RS08825	COG2089	acid synthase
HORE_RS08830	COG0110	maltose O-acetyltransferase activity
HORE_RS08835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HORE_RS08840	COG1086	Polysaccharide biosynthesis protein
HORE_RS08845	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HORE_RS08850	COG2089	acid synthase
HORE_RS08865	COG1516	flagellar protein fliS
HORE_RS08870	COG2604	Protein of unknown function DUF115
HORE_RS08880	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HORE_RS08890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HORE_RS08895	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HORE_RS08900	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HORE_RS08920	COG1256	bacterial-type flagellum assembly
HORE_RS08920	COG4786	Flagellar basal body rod
HORE_RS08945	COG0438	transferase activity, transferring glycosyl groups
HORE_RS08950	COG0859	PFAM glycosyl transferase family 9
HORE_RS08990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HORE_RS09000	COG0069	glutamate synthase activity
HORE_RS09005	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HORE_RS09025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HORE_RS09035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HORE_RS09040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HORE_RS09040	COG2199	diguanylate cyclase activity
HORE_RS09055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HORE_RS09095	COG4372	Transposase
HORE_RS09105	COG1137	ATPase activity
HORE_RS09120	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HORE_RS09125	COG3494	Protein of unknown function (DUF1009)
HORE_RS09130	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HORE_RS09135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HORE_RS09140	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HORE_RS09145	COG1126	abc transporter atp-binding protein
HORE_RS09175	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HORE_RS09195	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HORE_RS09205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HORE_RS09220	COG1077	Cell shape determining protein MreB Mrl
HORE_RS09225	COG1609	Transcriptional regulator
HORE_RS09235	COG2385	sporulation resulting in formation of a cellular spore
HORE_RS09240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HORE_RS09250	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HORE_RS09255	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HORE_RS09260	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HORE_RS09265	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HORE_RS09270	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HORE_RS09275	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HORE_RS09285	COG0356	it plays a direct role in the translocation of protons across the membrane
HORE_RS09300	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HORE_RS09305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HORE_RS09310	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HORE_RS09320	COG1971	Probably functions as a manganese efflux pump
HORE_RS09325	COG0009	L-threonylcarbamoyladenylate synthase
HORE_RS09330	COG2890	protein-(glutamine-N5) methyltransferase activity
HORE_RS09335	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HORE_RS09340	COG3872	metal-dependent enzyme
HORE_RS09350	COG0254	rRNA binding
HORE_RS09355	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HORE_RS09380	COG0504	CTP synthase activity
HORE_RS09400	COG0719	Fe-S assembly protein
HORE_RS09405	COG1137	ATPase activity
HORE_RS09410	COG3118	belongs to the thioredoxin family
HORE_RS09420	COG1362	aminopeptidase activity
HORE_RS09430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HORE_RS09445	COG0785	Cytochrome C biogenesis protein
HORE_RS09450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HORE_RS09455	COG0438	transferase activity, transferring glycosyl groups
HORE_RS09460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HORE_RS09485	COG1342	Belongs to the UPF0251 family
HORE_RS09490	COG0497	DNA recombination
HORE_RS09495	COG1151	hydroxylamine reductase activity
HORE_RS09515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HORE_RS09520	COG1121	(ABC) transporter
HORE_RS09525	COG0803	Belongs to the bacterial solute-binding protein 9 family
HORE_RS09535	COG2894	cell division
HORE_RS09540	COG0489	protein tyrosine kinase activity
HORE_RS09555	COG0733	neurotransmitter:sodium symporter activity
HORE_RS09560	COG1732	Glycine betaine
HORE_RS09565	COG1174	glycine betaine transport
HORE_RS09570	COG0517	IMP dehydrogenase activity
HORE_RS09570	COG1125	glycine betaine transport
HORE_RS09590	COG0534	Mate efflux family protein
HORE_RS09655	COG4796	Type ii and iii secretion system protein
HORE_RS09690	COG1459	type II secretion system
HORE_RS09695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HORE_RS09715	COG0765	amino acid transport
HORE_RS09720	COG1126	abc transporter atp-binding protein
HORE_RS09725	COG0765	amino acid transport
HORE_RS09730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HORE_RS09735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HORE_RS09790	COG0859	PFAM glycosyl transferase family 9
HORE_RS09795	COG1519	Transferase
HORE_RS09810	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HORE_RS09820	COG1663	tetraacyldisaccharide 4'-kinase activity
HORE_RS09825	COG2121	Domain of unknown function (DUF374)
HORE_RS09830	COG1132	(ABC) transporter
HORE_RS09845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HORE_RS09860	COG0714	Associated with various cellular activities
HORE_RS09865	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HORE_RS09875	COG0427	acetyl-CoA hydrolase
HORE_RS09880	COG0166	Belongs to the GPI family
HORE_RS09890	COG1592	Rubrerythrin
HORE_RS09900	COG1522	sequence-specific DNA binding
HORE_RS09905	COG1956	GAF domain-containing protein
HORE_RS09920	COG1757	Na H antiporter
HORE_RS09925	COG3457	Alanine racemase
HORE_RS09930	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HORE_RS09940	COG0546	phosphoglycolate phosphatase activity
HORE_RS09945	COG1609	Transcriptional regulator
HORE_RS09965	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HORE_RS09970	COG0071	Belongs to the small heat shock protein (HSP20) family
HORE_RS09990	COG1132	(ABC) transporter
HORE_RS10000	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HORE_RS10015	COG0704	Plays a role in the regulation of phosphate uptake
HORE_RS10020	COG0058	SHG alpha-glucan phosphorylase activity
HORE_RS10025	COG0438	transferase activity, transferring glycosyl groups
HORE_RS10035	COG1394	ATPase activity, coupled to movement of substances
HORE_RS10040	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HORE_RS10045	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HORE_RS10050	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HORE_RS10065	COG1269	ATP hydrolysis coupled proton transport
HORE_RS10085	COG4214	carbohydrate transport
HORE_RS10090	COG1129	ABC transporter
HORE_RS10095	COG4213	ABC transporter substrate-binding protein
HORE_RS10100	COG1070	Carbohydrate kinase
HORE_RS10105	COG1082	Xylose isomerase domain protein TIM barrel
HORE_RS10110	COG2115	Belongs to the xylose isomerase family
HORE_RS10120	COG1523	belongs to the glycosyl hydrolase 13 family
HORE_RS10125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HORE_RS10130	COG2873	o-acetylhomoserine
HORE_RS10135	COG0646	methionine synthase
HORE_RS10135	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HORE_RS10140	COG1410	methionine synthase
HORE_RS10140	COG0646	methionine synthase
HORE_RS10180	COG1136	(ABC) transporter
HORE_RS10210	COG4555	ABC transporter
HORE_RS10215	COG0840	transmembrane signaling receptor activity
HORE_RS10220	COG3459	Glycosyltransferase 36 associated
HORE_RS10225	COG3459	Glycosyltransferase 36 associated
HORE_RS10235	COG0395	ABC-type sugar transport system, permease component
HORE_RS10240	COG1175	transmembrane transport
HORE_RS10245	COG1609	Transcriptional regulator
HORE_RS10280	COG0395	ABC-type sugar transport system, permease component
HORE_RS10295	COG1653	transport
HORE_RS10310	COG2257	FlhB HrpN YscU SpaS Family
HORE_RS10315	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HORE_RS10325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HORE_RS10330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HORE_RS10335	COG4120	Belongs to the binding-protein-dependent transport system permease family
HORE_RS10350	COG2210	Belongs to the sulfur carrier protein TusA family
HORE_RS10380	COG1309	transcriptional regulator
HORE_RS10395	COG0640	Transcriptional regulator
HORE_RS10425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HORE_RS10430	COG3711	transcriptional antiterminator
HORE_RS10450	COG0732	type I restriction modification DNA specificity domain
HORE_RS10465	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HORE_RS10470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HORE_RS10475	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HORE_RS10480	COG2201	protein-glutamate methylesterase activity
HORE_RS10485	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HORE_RS10490	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HORE_RS10495	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HORE_RS10495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HORE_RS10500	COG1979	alcohol dehydrogenase
HORE_RS10505	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HORE_RS10510	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HORE_RS10515	COG4467	Involved in initiation control of chromosome replication
HORE_RS10520	COG1774	PSP1 C-terminal conserved region
HORE_RS10525	COG0470	DNA polymerase III
HORE_RS10535	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HORE_RS10550	COG0492	ferredoxin-NADP+ reductase activity
HORE_RS10570	COG3833	ABC-type maltose transport systems, permease component
HORE_RS10575	COG1175	transmembrane transport
HORE_RS10585	COG0517	IMP dehydrogenase activity
HORE_RS10585	COG0516	GMP reductase activity
HORE_RS10590	COG3250	beta-galactosidase activity
HORE_RS10595	COG0395	ABC-type sugar transport system, permease component
HORE_RS10600	COG1175	transmembrane transport
HORE_RS10605	COG1653	transport
HORE_RS10615	COG2909	trisaccharide binding
HORE_RS10630	COG0596	Alpha beta hydrolase
HORE_RS10645	COG3250	beta-galactosidase activity
HORE_RS10655	COG0395	ABC-type sugar transport system, permease component
HORE_RS10660	COG1175	transmembrane transport
HORE_RS10665	COG2182	Extracellular solute-binding protein
HORE_RS10675	COG0006	proline dipeptidase activity
HORE_RS10680	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HORE_RS10685	COG1085	galactose-1-phosphate uridylyltransferase
HORE_RS10690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HORE_RS10705	COG1013	pyruvate-flavodoxin oxidoreductase activity
HORE_RS10710	COG0674	pyruvate-flavodoxin oxidoreductase activity
HORE_RS10715	COG1144	Oxidoreductase
HORE_RS10720	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HORE_RS10735	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HORE_RS10740	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HORE_RS10745	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HORE_RS10770	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HORE_RS10770	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HORE_RS10770	COG1013	pyruvate-flavodoxin oxidoreductase activity
HORE_RS10770	COG0674	pyruvate-flavodoxin oxidoreductase activity
HORE_RS10775	COG1554	hydrolase, family 65, central catalytic
HORE_RS10795	COG1653	transport
HORE_RS10805	COG2964	Protein conserved in bacteria
HORE_RS10810	COG3033	Beta-eliminating lyase
HORE_RS10815	COG0733	neurotransmitter:sodium symporter activity
HORE_RS10820	COG0251	oxidation-reduction process
HORE_RS10825	COG2217	Heavy metal translocating P-type atpase
HORE_RS10830	COG0037	tRNA processing
HORE_RS10845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HORE_RS10850	COG0179	Fumarylacetoacetate (FAA) hydrolase
HORE_RS10855	COG0840	transmembrane signaling receptor activity
HORE_RS10860	COG0446	pyridine nucleotide-disulphide oxidoreductase
HORE_RS10875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HORE_RS10890	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HORE_RS10895	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HORE_RS10900	COG5012	cobalamin binding
HORE_RS10915	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HORE_RS10935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HORE_RS10960	COG2385	sporulation resulting in formation of a cellular spore
HORE_RS10965	COG1686	Belongs to the peptidase S11 family
HORE_RS10970	COG3956	TIGRFAM MazG family protein
HORE_RS10975	COG2244	polysaccharide biosynthetic process
HORE_RS10980	COG2002	toxin-antitoxin pair type II binding
HORE_RS10985	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HORE_RS10990	COG0193	aminoacyl-tRNA hydrolase activity
HORE_RS10995	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HORE_RS11000	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HORE_RS11005	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HORE_RS11015	COG2088	sporulation resulting in formation of a cellular spore
HORE_RS11020	COG0709	Synthesizes selenophosphate from selenide and ATP
HORE_RS11035	COG0789	Transcriptional regulator
HORE_RS11055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HORE_RS11065	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HORE_RS11075	COG1376	ErfK ybiS ycfS ynhG family protein
HORE_RS11080	COG0387	Pfam Sodium calcium exchanger
HORE_RS11085	COG1388	LysM domain
HORE_RS11090	COG1376	ErfK ybiS ycfS ynhG family protein
HORE_RS11110	COG2340	Cysteine-rich secretory protein family
HORE_RS11120	COG1983	PspC domain protein
HORE_RS11125	COG0058	SHG alpha-glucan phosphorylase activity
HORE_RS11135	COG4176	ABC-type proline glycine betaine transport system permease component
HORE_RS11150	COG1482	cell wall glycoprotein biosynthetic process
HORE_RS11155	COG0704	Plays a role in the regulation of phosphate uptake
HORE_RS11160	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HORE_RS11165	COG0581	inorganic phosphate transmembrane transporter activity
HORE_RS11170	COG0573	inorganic phosphate transmembrane transporter activity
HORE_RS11180	COG0840	transmembrane signaling receptor activity
HORE_RS11195	COG0573	inorganic phosphate transmembrane transporter activity
HORE_RS11200	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HORE_RS11205	COG5002	protein histidine kinase activity
HORE_RS11210	COG0745	RESPONSE REGULATOR receiver
HORE_RS11215	COG1283	sodium-dependent phosphate transmembrane transporter activity
HORE_RS11225	COG1388	LysM domain
HORE_RS11225	COG3858	chitin binding
HORE_RS11235	COG4466	Protein conserved in bacteria
HORE_RS11250	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HORE_RS11275	COG2814	Major facilitator Superfamily
HORE_RS11280	COG2707	UPF0756 membrane protein
HORE_RS11285	COG2045	Belongs to the ComB family
HORE_RS11290	COG1809	phosphosulfolactate synthase activity
HORE_RS11305	COG2197	response regulator
HORE_RS11315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HORE_RS11320	COG0840	transmembrane signaling receptor activity
HORE_RS11330	COG3426	butyrate kinase activity
HORE_RS11335	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HORE_RS11345	COG1376	ErfK ybiS ycfS ynhG family protein
HORE_RS11355	COG0084	hydrolase, TatD family'
HORE_RS11360	COG2814	Major facilitator Superfamily
HORE_RS11420	COG2244	polysaccharide biosynthetic process
HORE_RS11430	COG0301	tRNA thio-modification
HORE_RS11435	COG2323	membrane
HORE_RS11445	COG0138	bifunctional purine biosynthesis protein purh
HORE_RS11450	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HORE_RS11455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HORE_RS11460	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HORE_RS11465	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HORE_RS11470	COG0047	phosphoribosylformylglycinamidine synthase activity
HORE_RS11485	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HORE_RS11495	COG1475	DNA binding
HORE_RS11500	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HORE_RS11520	COG0489	protein tyrosine kinase activity
HORE_RS11525	COG1388	LysM domain
HORE_RS11525	COG0791	NLP P60 protein
HORE_RS11540	COG1533	DNA photolyase activity
HORE_RS11545	COG1464	Belongs to the NlpA lipoprotein family
HORE_RS11550	COG2011	ABC-type metal ion transport system permease component
HORE_RS11555	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HORE_RS11590	COG0640	Transcriptional regulator
HORE_RS11605	COG4667	esterase of the alpha-beta hydrolase superfamily
HORE_RS11610	COG0367	asparagine synthase
HORE_RS11635	COG2270	Major facilitator Superfamily
HORE_RS11655	COG0426	domain, Protein
HORE_RS11675	COG0366	Alpha amylase catalytic
HORE_RS11690	COG0840	transmembrane signaling receptor activity
HORE_RS11695	COG2201	protein-glutamate methylesterase activity
HORE_RS11700	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HORE_RS11705	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HORE_RS11720	COG0745	RESPONSE REGULATOR receiver
HORE_RS11735	COG0529	Catalyzes the synthesis of activated sulfate
HORE_RS11740	COG2046	Belongs to the sulfate adenylyltransferase family
HORE_RS11745	COG0840	transmembrane signaling receptor activity
HORE_RS11750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HORE_RS11755	COG1172	Belongs to the binding-protein-dependent transport system permease family
HORE_RS11760	COG1129	ABC transporter
HORE_RS11765	COG1879	ABC-type sugar transport system periplasmic component
HORE_RS11770	COG1105	Belongs to the carbohydrate kinase PfkB family
HORE_RS11775	COG2222	sugar isomerase
HORE_RS11785	COG1940	carbohydrate kinase activity
HORE_RS11800	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HORE_RS11805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HORE_RS11810	COG1215	transferase activity, transferring glycosyl groups
HORE_RS11825	COG0438	transferase activity, transferring glycosyl groups
HORE_RS11830	COG0438	transferase activity, transferring glycosyl groups
HORE_RS11870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HORE_RS11875	COG0363	glucosamine-6-phosphate deaminase activity
HORE_RS11885	COG2188	Transcriptional regulator
HORE_RS11890	COG1929	Belongs to the glycerate kinase type-1 family
HORE_RS11895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HORE_RS11900	COG0383	alpha-mannosidase activity
HORE_RS11910	COG1175	transmembrane transport
HORE_RS11915	COG1653	transport
HORE_RS11920	COG1609	Transcriptional regulator
HORE_RS11940	COG3546	catalase activity
HORE_RS11945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HORE_RS11955	COG1045	serine acetyltransferase
HORE_RS11960	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HORE_RS11965	COG0151	Belongs to the GarS family
HORE_RS11970	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HORE_RS11975	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HORE_RS11990	COG0305	Participates in initiation and elongation during chromosome replication
HORE_RS12000	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HORE_RS12015	COG1082	Xylose isomerase domain protein TIM barrel
HORE_RS12020	COG0366	Alpha amylase catalytic
HORE_RS12035	COG4591	ABC-type transport system involved in lipoprotein release permease component
HORE_RS12040	COG0577	efflux transmembrane transporter activity
HORE_RS12040	COG1136	(ABC) transporter
HORE_RS12045	COG1136	(ABC) transporter
HORE_RS12045	COG0577	efflux transmembrane transporter activity
HORE_RS12050	COG4591	ABC-type transport system involved in lipoprotein release permease component
HORE_RS12055	COG4591	ABC-type transport system involved in lipoprotein release permease component
HORE_RS12065	COG2207	Transcriptional regulator
HORE_RS12070	COG1486	melibiose metabolic process
HORE_RS12075	COG1067	ATP-dependent peptidase activity
HORE_RS12075	COG0470	DNA polymerase III
HORE_RS12080	COG0359	binds to the 23S rRNA
HORE_RS12095	COG0629	single-stranded DNA binding
HORE_RS12100	COG0360	Binds together with S18 to 16S ribosomal RNA
HORE_RS12105	COG0012	GTP binding
HORE_RS12110	COG4481	Protein conserved in bacteria
HORE_RS12115	COG0668	transmembrane transport
HORE_RS12125	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HORE_RS12130	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HORE_RS12135	COG0509	glycine decarboxylation via glycine cleavage system
HORE_RS12140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HORE_RS12170	COG1811	Na channel or pump
HORE_RS12175	COG1475	DNA binding
HORE_RS12180	COG1192	Involved in chromosome partitioning
HORE_RS12185	COG1475	DNA binding
HORE_RS12190	COG0357	Ribosomal RNA small subunit methyltransferase G
HORE_RS12200	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HORE_RS12205	COG1847	R3H domain protein
HORE_RS12210	COG0706	membrane insertase activity
HORE_RS12215	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HORE_RS12220	COG0594	ribonuclease P activity
HORE_RS12250	COG0840	transmembrane signaling receptor activity
HORE_RS12270	COG2323	membrane
HORE_RS12275	COG2323	membrane
HORE_RS12310	COG0739	heme binding
HORE_RS12320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HORE_RS12360	COG3773	Cell wall hydrolase
HORE_RS12360	COG3409	Peptidoglycan-binding domain 1 protein
HORE_RS12380	COG1396	sequence-specific DNA binding
HORE_RS12385	COG0860	N-Acetylmuramoyl-L-alanine amidase
HORE_RS12405	COG0750	zinc metalloprotease
HORE_RS12420	COG0598	Magnesium transport protein CorA
HORE_RS12425	COG0598	Magnesium transport protein CorA
HORE_RS12435	COG1196	nuclear chromosome segregation
HORE_RS12450	COG5416	Lipopolysaccharide assembly protein A domain
HORE_RS12485	COG2203	Gaf domain
HORE_RS12485	COG2199	diguanylate cyclase activity
HORE_RS12490	COG2226	methyltransferase
HORE_RS12505	COG0860	N-Acetylmuramoyl-L-alanine amidase
HORE_RS12505	COG2247	cell wall binding repeat
HORE_RS12510	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HORE_RS12535	COG4942	peptidase
HORE_RS12540	COG0698	ribose 5-phosphate isomerase
HORE_RS12560	COG0840	transmembrane signaling receptor activity
HORE_RS12565	COG0840	transmembrane signaling receptor activity
HORE_RS12570	COG1396	sequence-specific DNA binding
HORE_RS12590	COG1388	LysM domain
HORE_RS12590	COG1705	Flagellar rod assembly protein muramidase FlgJ
HORE_RS12600	COG0739	heme binding