locus-tag	class	description
CDV25_RS00040	COG0534	Mate efflux family protein
CDV25_RS00055	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CDV25_RS00060	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CDV25_RS00075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CDV25_RS00080	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CDV25_RS00085	COG0409	Hydrogenase expression formation protein
CDV25_RS00090	COG0315	cyclic pyranopterin monophosphate synthase activity
CDV25_RS00240	COG0826	peptidase U32
CDV25_RS00245	COG0129	dihydroxy-acid dehydratase activity
CDV25_RS00260	COG0051	transcription antitermination factor activity, RNA binding
CDV25_RS00265	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CDV25_RS00270	COG0088	Forms part of the polypeptide exit tunnel
CDV25_RS00275	COG0089	rRNA binding
CDV25_RS00280	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CDV25_RS00285	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CDV25_RS00290	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CDV25_RS00295	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CDV25_RS00300	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CDV25_RS00305	COG0255	Belongs to the universal ribosomal protein uL29 family
CDV25_RS00310	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CDV25_RS00315	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CDV25_RS00320	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CDV25_RS00325	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CDV25_RS00330	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CDV25_RS00335	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CDV25_RS00340	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CDV25_RS00345	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CDV25_RS00350	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CDV25_RS00355	COG0200	Binds to the 23S rRNA
CDV25_RS00365	COG0024	Methionine aminopeptidase
CDV25_RS00370	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CDV25_RS00375	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CDV25_RS00380	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CDV25_RS00385	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CDV25_RS00390	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CDV25_RS00395	COG0202	RNA polymerase activity
CDV25_RS00400	COG0203	ribosomal protein L17
CDV25_RS00410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CDV25_RS00420	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CDV25_RS00420	COG1776	CheC inhibitor of MCP methylation
CDV25_RS00435	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CDV25_RS00450	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CDV25_RS00465	COG0148	phosphopyruvate hydratase activity
CDV25_RS00470	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CDV25_RS00475	COG0793	Belongs to the peptidase S41A family
CDV25_RS00480	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CDV25_RS00490	COG0047	phosphoribosylformylglycinamidine synthase activity
CDV25_RS00500	COG0204	Acyl-transferase
CDV25_RS00515	COG0436	Aminotransferase
CDV25_RS00530	COG1193	negative regulation of DNA recombination
CDV25_RS00545	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CDV25_RS00565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDV25_RS00590	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CDV25_RS00595	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CDV25_RS00605	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CDV25_RS00610	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CDV25_RS00615	COG0347	Belongs to the P(II) protein family
CDV25_RS00620	COG0004	ammonium transporteR
CDV25_RS00635	COG4773	Receptor
CDV25_RS00640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CDV25_RS00640	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CDV25_RS00645	COG0861	Integral membrane protein TerC family
CDV25_RS00665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDV25_RS00680	COG1064	alcohol dehydrogenase
CDV25_RS00685	COG0731	radical SAM domain protein
CDV25_RS00695	COG0101	tRNA pseudouridine synthase activity
CDV25_RS00700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CDV25_RS00705	COG1049	propionate catabolic process, 2-methylcitrate cycle
CDV25_RS00720	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CDV25_RS00725	COG0563	adenylate kinase activity
CDV25_RS00730	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CDV25_RS00735	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CDV25_RS00740	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CDV25_RS00750	COG0785	Cytochrome C biogenesis protein
CDV25_RS00755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CDV25_RS00770	COG2257	FlhB HrpN YscU SpaS Family
CDV25_RS00780	COG0084	hydrolase, TatD family'
CDV25_RS00795	COG0194	GDP metabolic process
CDV25_RS00800	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CDV25_RS00820	COG0824	Thioesterase
CDV25_RS00825	COG0840	transmembrane signaling receptor activity
CDV25_RS00830	COG1086	Polysaccharide biosynthesis protein
CDV25_RS00835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CDV25_RS00840	COG1083	cytidylyl-transferase
CDV25_RS00850	COG4773	Receptor
CDV25_RS00855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CDV25_RS00860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CDV25_RS00865	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CDV25_RS00885	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CDV25_RS00890	COG1053	succinate dehydrogenase
CDV25_RS00910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CDV25_RS00915	COG0768	penicillin binding
CDV25_RS00925	COG1558	bacterial-type flagellum-dependent cell motility
CDV25_RS00950	COG0523	cobalamin synthesis protein
CDV25_RS00955	COG0359	binds to the 23S rRNA
CDV25_RS00960	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CDV25_RS00980	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CDV25_RS00990	COG0037	tRNA processing
CDV25_RS00995	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CDV25_RS01000	COG0280	phosphate acetyltransferase
CDV25_RS01010	COG0776	regulation of translation
CDV25_RS01025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CDV25_RS01035	COG0402	S-adenosylhomocysteine deaminase activity
CDV25_RS01040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CDV25_RS01045	COG0418	dihydroorotase activity
CDV25_RS01050	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CDV25_RS01055	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CDV25_RS01060	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CDV25_RS01075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CDV25_RS01080	COG0745	RESPONSE REGULATOR receiver
CDV25_RS01085	COG5002	protein histidine kinase activity
CDV25_RS01085	COG3850	Histidine kinase
CDV25_RS01100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CDV25_RS01125	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CDV25_RS01130	COG0367	asparagine synthase
CDV25_RS01175	COG0110	maltose O-acetyltransferase activity
CDV25_RS01225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CDV25_RS01245	COG0367	asparagine synthase
CDV25_RS01265	COG2194	sulfuric ester hydrolase activity
CDV25_RS01270	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CDV25_RS01280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CDV25_RS01285	COG0367	asparagine synthase
CDV25_RS01325	COG0367	asparagine synthase
CDV25_RS01340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CDV25_RS01345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CDV25_RS01360	COG0529	Catalyzes the synthesis of activated sulfate
CDV25_RS01395	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CDV25_RS01400	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CDV25_RS01405	COG1966	Carbon starvation protein
CDV25_RS01420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDV25_RS01445	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CDV25_RS01465	COG1136	(ABC) transporter
CDV25_RS01470	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CDV25_RS01480	COG0564	pseudouridine synthase activity
CDV25_RS01485	COG0772	Belongs to the SEDS family
CDV25_RS01500	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CDV25_RS01510	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CDV25_RS01515	COG2201	protein-glutamate methylesterase activity
CDV25_RS01520	COG1739	Uncharacterized protein family UPF0029
CDV25_RS01530	COG0540	Belongs to the ATCase OTCase family
CDV25_RS01540	COG2860	membrane
CDV25_RS01545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDV25_RS01550	COG0191	fructose-bisphosphate aldolase activity
CDV25_RS01570	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CDV25_RS01580	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CDV25_RS01585	COG0157	Belongs to the NadC ModD family
CDV25_RS01590	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CDV25_RS01595	COG0489	protein tyrosine kinase activity
CDV25_RS01600	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CDV25_RS01605	COG4773	Receptor
CDV25_RS01615	COG0754	glutathionylspermidine amidase activity
CDV25_RS01620	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CDV25_RS01625	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CDV25_RS01630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CDV25_RS01655	COG2079	MmgE PrpD family protein
CDV25_RS01660	COG0372	Belongs to the citrate synthase family
CDV25_RS01665	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CDV25_RS01680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CDV25_RS01685	COG1120	ATPase activity
CDV25_RS01690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CDV25_RS01695	COG0582	viral genome integration into host DNA
CDV25_RS01710	COG0745	RESPONSE REGULATOR receiver
CDV25_RS01715	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CDV25_RS01720	COG0372	Belongs to the citrate synthase family
CDV25_RS01725	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CDV25_RS01730	COG0653	protein targeting
CDV25_RS01735	COG4591	ABC-type transport system involved in lipoprotein release permease component
CDV25_RS01745	COG1187	pseudouridine synthase activity
CDV25_RS01755	COG0587	DNA-directed DNA polymerase activity
CDV25_RS01760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CDV25_RS01780	COG1408	metallophosphoesterase
CDV25_RS01830	COG1393	Belongs to the ArsC family
CDV25_RS01840	COG1121	(ABC) transporter
CDV25_RS01845	COG0579	oxidoreductase
CDV25_RS01850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CDV25_RS01865	COG0778	Nitroreductase
CDV25_RS01880	COG0328	RNA-DNA hybrid ribonuclease activity
CDV25_RS01885	COG0571	ribonuclease III activity
CDV25_RS01890	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CDV25_RS01905	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CDV25_RS01910	COG1338	Plays a role in the flagellum-specific transport system
CDV25_RS01915	COG1360	Flagellar Motor Protein
CDV25_RS01925	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CDV25_RS01935	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CDV25_RS01940	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDV25_RS01945	COG0835	chemotaxis
CDV25_RS01945	COG0784	Response regulator, receiver
CDV25_RS01950	COG0784	Response regulator, receiver
CDV25_RS01950	COG2198	Histidine kinase
CDV25_RS01950	COG0643	Histidine kinase
CDV25_RS01955	COG0835	chemotaxis
CDV25_RS01965	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CDV25_RS01980	COG0527	aspartate kinase activity
CDV25_RS01985	COG0494	nUDIX hydrolase
CDV25_RS01995	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CDV25_RS02000	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CDV25_RS02020	COG0848	biopolymer transport protein
CDV25_RS02025	COG0811	peptide transport
CDV25_RS02030	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CDV25_RS02035	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CDV25_RS02040	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CDV25_RS02045	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CDV25_RS02060	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CDV25_RS02070	COG0437	4 iron, 4 sulfur cluster binding
CDV25_RS02100	COG1013	pyruvate-flavodoxin oxidoreductase activity
CDV25_RS02105	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CDV25_RS02105	COG0674	pyruvate-flavodoxin oxidoreductase activity
CDV25_RS02115	COG0039	L-malate dehydrogenase activity
CDV25_RS02120	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CDV25_RS02130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CDV25_RS02135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDV25_RS02140	COG1126	abc transporter atp-binding protein
CDV25_RS02145	COG0765	amino acid transport
CDV25_RS02155	COG0138	bifunctional purine biosynthesis protein purh
CDV25_RS02165	COG0193	aminoacyl-tRNA hydrolase activity
CDV25_RS02170	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CDV25_RS02180	COG0560	Phosphoserine phosphatase
CDV25_RS02200	COG0716	FMN binding
CDV25_RS02250	COG0656	L-ascorbic acid biosynthetic process
CDV25_RS02340	COG0629	single-stranded DNA binding
CDV25_RS02380	COG0358	DNA primase activity
CDV25_RS02395	COG1442	glycosyl transferase family 8
CDV25_RS02435	COG1216	Glycosyl transferase, family 2
CDV25_RS02455	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CDV25_RS02460	COG1442	glycosyl transferase family 8
CDV25_RS02460	COG1216	Glycosyl transferase, family 2
CDV25_RS02470	COG1442	glycosyl transferase family 8
CDV25_RS02470	COG1216	Glycosyl transferase, family 2
CDV25_RS02475	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CDV25_RS02480	COG1063	alcohol dehydrogenase
CDV25_RS02485	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CDV25_RS02510	COG1007	ATP synthesis coupled electron transport
CDV25_RS02515	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDV25_RS02520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CDV25_RS02525	COG0713	ATP synthesis coupled electron transport
CDV25_RS02530	COG0839	Belongs to the complex I subunit 6 family
CDV25_RS02535	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDV25_RS02540	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CDV25_RS02560	COG0649	NAD binding
CDV25_RS02565	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDV25_RS02570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDV25_RS02575	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDV25_RS02590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CDV25_RS02590	COG2221	Nitrite and sulphite reductase 4Fe-4S
CDV25_RS02595	COG3043	anaerobic respiration
CDV25_RS02600	COG0348	domain, Protein
CDV25_RS02605	COG0437	4 iron, 4 sulfur cluster binding
CDV25_RS02610	COG0243	molybdopterin cofactor binding
CDV25_RS02615	COG0784	Response regulator, receiver
CDV25_RS02615	COG0835	chemotaxis
CDV25_RS02620	COG1132	(ABC) transporter
CDV25_RS02645	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CDV25_RS02650	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CDV25_RS02655	COG0735	belongs to the Fur family
CDV25_RS02680	COG0598	Magnesium transport protein CorA
CDV25_RS02685	COG0126	phosphoglycerate kinase activity
CDV25_RS02690	COG0642	Histidine kinase
CDV25_RS02695	COG3951	Flagellar rod assembly protein muramidase FlgJ
CDV25_RS02700	COG1706	bacterial-type flagellum-dependent cell motility
CDV25_RS02710	COG0730	response to heat
CDV25_RS02755	COG4106	trans-aconitate 2-methyltransferase activity
CDV25_RS02760	COG0196	riboflavin kinase activity
CDV25_RS02830	COG0459	protein refolding
CDV25_RS02835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CDV25_RS02840	COG0436	Aminotransferase
CDV25_RS02845	COG1012	belongs to the aldehyde dehydrogenase family
CDV25_RS02870	COG1749	Flagellar hook protein flgE
CDV25_RS02875	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CDV25_RS02885	COG1217	gtp-binding protein TYPA
CDV25_RS02890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CDV25_RS02895	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CDV25_RS02900	COG1570	exodeoxyribonuclease VII activity
CDV25_RS02905	COG5016	pyruvate
CDV25_RS02905	COG0511	ligase activity, forming carbon-carbon bonds
CDV25_RS02945	COG0302	gtp cyclohydrolase
CDV25_RS02955	COG0585	pseudouridine synthase activity
CDV25_RS02960	COG1047	Peptidyl-prolyl cis-trans
CDV25_RS02975	COG0823	Involved in the tonB-independent uptake of proteins
CDV25_RS02985	COG0848	biopolymer transport protein
CDV25_RS02990	COG0811	peptide transport
CDV25_RS02995	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CDV25_RS03005	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CDV25_RS03010	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CDV25_RS03015	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CDV25_RS03020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CDV25_RS03030	COG1475	DNA binding
CDV25_RS03035	COG1192	Involved in chromosome partitioning
CDV25_RS03040	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CDV25_RS03040	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CDV25_RS03045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CDV25_RS03050	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CDV25_RS03055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CDV25_RS03060	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CDV25_RS03065	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CDV25_RS03070	COG0251	oxidation-reduction process
CDV25_RS03085	COG0314	molybdopterin synthase activity
CDV25_RS03095	COG0521	Mo-molybdopterin cofactor biosynthetic process
CDV25_RS03100	COG0616	signal peptide processing
CDV25_RS03105	COG3338	carbonate dehydratase activity
CDV25_RS03115	COG0481	GTPase activity
CDV25_RS03125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CDV25_RS03140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CDV25_RS03145	COG0268	Binds directly to 16S ribosomal RNA
CDV25_RS03150	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CDV25_RS03160	COG0425	Belongs to the sulfur carrier protein TusA family
CDV25_RS03165	COG2391	methyltransferase activity
CDV25_RS03180	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CDV25_RS03185	COG0575	Belongs to the CDS family
CDV25_RS03190	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CDV25_RS03210	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CDV25_RS03215	COG0525	valine-tRNA ligase activity
CDV25_RS03220	COG0628	permease
CDV25_RS03225	COG0348	domain, Protein
CDV25_RS03230	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CDV25_RS03245	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CDV25_RS03250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CDV25_RS03255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CDV25_RS03280	COG0583	DNA-binding transcription factor activity
CDV25_RS03295	COG0753	catalase activity
CDV25_RS03305	COG0309	Hydrogenase expression formation protein (HypE)
CDV25_RS03375	COG0675	Transposase, IS605 OrfB family
CDV25_RS03390	COG2081	HI0933 family
CDV25_RS03395	COG0825	malonyl-CoA metabolic process
CDV25_RS03400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CDV25_RS03405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CDV25_RS03415	COG3022	response to hydroperoxide
CDV25_RS03430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CDV25_RS03435	COG1045	serine acetyltransferase
CDV25_RS03440	COG1166	arginine decarboxylase activity
CDV25_RS03460	COG0646	methionine synthase
CDV25_RS03460	COG1410	methionine synthase
CDV25_RS03465	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDV25_RS03470	COG0586	Pfam SNARE associated Golgi protein
CDV25_RS03475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CDV25_RS03490	COG0646	methionine synthase
CDV25_RS03490	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CDV25_RS03495	COG0772	Belongs to the SEDS family
CDV25_RS03500	COG0019	diaminopimelate decarboxylase activity
CDV25_RS03515	COG0736	holo-[acyl-carrier-protein] synthase activity
CDV25_RS03520	COG0424	maF-like protein
CDV25_RS03530	COG0492	ferredoxin-NADP+ reductase activity
CDV25_RS03535	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CDV25_RS03545	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CDV25_RS03550	COG1692	metallophosphoesterase
CDV25_RS03565	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CDV25_RS03575	COG0739	heme binding
CDV25_RS03595	COG0495	leucyl-tRNA aminoacylation
CDV25_RS03605	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CDV25_RS03610	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CDV25_RS03615	COG1862	Preprotein translocase
CDV25_RS03640	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CDV25_RS03655	COG0789	Transcriptional regulator
CDV25_RS03680	COG0738	Major facilitator superfamily
CDV25_RS03695	COG0363	glucosamine-6-phosphate deaminase activity
CDV25_RS03705	COG0129	dihydroxy-acid dehydratase activity
CDV25_RS03710	COG0800	Aldolase
CDV25_RS03730	COG0765	amino acid transport
CDV25_RS03735	COG1126	abc transporter atp-binding protein
CDV25_RS03740	COG0728	peptidoglycan biosynthetic process
CDV25_RS03750	COG0632	four-way junction helicase activity
CDV25_RS03755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CDV25_RS03780	COG2171	N-acyltransferase activity
CDV25_RS03790	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CDV25_RS03795	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CDV25_RS03800	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CDV25_RS03815	COG0756	dUTP diphosphatase activity
CDV25_RS03820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CDV25_RS03825	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDV25_RS03840	COG0739	heme binding
CDV25_RS03845	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CDV25_RS03855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CDV25_RS03885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CDV25_RS03885	COG1333	cytochrome c biogenesis protein
CDV25_RS03890	COG0765	amino acid transport
CDV25_RS03895	COG0765	amino acid transport
CDV25_RS03900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDV25_RS03905	COG1126	abc transporter atp-binding protein
CDV25_RS03930	COG4771	TonB-dependent receptor
CDV25_RS03935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CDV25_RS03940	COG1120	ATPase activity
CDV25_RS03945	COG1160	GTP binding
CDV25_RS03955	COG0352	thiamine-phosphate diphosphorylase activity
CDV25_RS03960	COG0670	Belongs to the BI1 family
CDV25_RS03965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CDV25_RS03975	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CDV25_RS03990	COG0428	transporter
CDV25_RS03995	COG1013	pyruvate-flavodoxin oxidoreductase activity
CDV25_RS04000	COG0674	pyruvate-flavodoxin oxidoreductase activity
CDV25_RS04005	COG1144	Oxidoreductase
CDV25_RS04015	COG0546	phosphoglycolate phosphatase activity
CDV25_RS04020	COG2176	DNA-directed DNA polymerase activity
CDV25_RS04055	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CDV25_RS04060	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CDV25_RS04065	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CDV25_RS04070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CDV25_RS04080	COG0275	rRNA processing
CDV25_RS04085	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CDV25_RS04110	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CDV25_RS04120	COG1242	4 iron, 4 sulfur cluster binding
CDV25_RS04125	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CDV25_RS04130	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CDV25_RS04135	COG0492	ferredoxin-NADP+ reductase activity
CDV25_RS04145	COG3118	belongs to the thioredoxin family
CDV25_RS04150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CDV25_RS04155	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CDV25_RS04165	COG0288	reversible hydration of carbon dioxide
CDV25_RS04185	COG1252	NADH dehydrogenase
CDV25_RS04200	COG0517	IMP dehydrogenase activity
CDV25_RS04200	COG0516	GMP reductase activity
CDV25_RS04205	COG0154	amidase activity
CDV25_RS04210	COG1981	membrane
CDV25_RS04215	COG0165	Argininosuccinate lyase
CDV25_RS04235	COG0174	glutamine synthetase
CDV25_RS04265	COG2217	Heavy metal translocating P-type atpase
CDV25_RS04280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDV25_RS04285	COG1136	(ABC) transporter
CDV25_RS04290	COG0577	efflux transmembrane transporter activity
CDV25_RS04290	COG1136	(ABC) transporter
CDV25_RS04295	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CDV25_RS04300	COG0594	ribonuclease P activity
CDV25_RS04305	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CDV25_RS04310	COG0706	membrane insertase activity
CDV25_RS04320	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CDV25_RS04395	COG1673	EVE domain
CDV25_RS04400	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CDV25_RS04445	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CDV25_RS04455	COG2076	Multidrug Resistance protein
CDV25_RS04460	COG2076	Multidrug Resistance protein
CDV25_RS04475	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CDV25_RS04570	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CDV25_RS04580	COG0322	excinuclease ABC activity
CDV25_RS04640	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CDV25_RS04645	COG1793	dna ligase
CDV25_RS04650	COG2095	MarC family integral membrane protein
CDV25_RS04655	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CDV25_RS04660	COG1607	acyl-coa hydrolase
CDV25_RS04675	COG0375	protein maturation
CDV25_RS04680	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CDV25_RS04690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CDV25_RS04695	COG0247	lactate metabolic process
CDV25_RS04700	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CDV25_RS04700	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CDV25_RS04705	COG0745	RESPONSE REGULATOR receiver
CDV25_RS04730	COG0701	Predicted permease
CDV25_RS04765	COG0210	DNA helicase
CDV25_RS04790	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CDV25_RS04870	COG1988	membrane-bound metal-dependent
CDV25_RS04960	COG0629	single-stranded DNA binding
CDV25_RS04980	COG0697	spore germination
CDV25_RS04985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CDV25_RS05015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CDV25_RS05040	COG2217	Heavy metal translocating P-type atpase
CDV25_RS05045	COG0640	Transcriptional regulator
CDV25_RS05070	COG1749	Flagellar hook protein flgE
CDV25_RS05095	COG0356	it plays a direct role in the translocation of protons across the membrane
CDV25_RS05115	COG0233	cytoplasmic translational termination
CDV25_RS05120	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CDV25_RS05130	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CDV25_RS05140	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CDV25_RS05145	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
CDV25_RS05150	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CDV25_RS05155	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CDV25_RS05170	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CDV25_RS05180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CDV25_RS05185	COG0277	FAD linked oxidase domain protein
CDV25_RS05195	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CDV25_RS05200	COG0612	Peptidase, M16
CDV25_RS05205	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CDV25_RS05210	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CDV25_RS05215	COG0287	Prephenate dehydrogenase
CDV25_RS05220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CDV25_RS05220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CDV25_RS05225	COG0779	Required for maturation of 30S ribosomal subunits
CDV25_RS05230	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CDV25_RS05235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CDV25_RS05235	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CDV25_RS05265	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CDV25_RS05270	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CDV25_RS05275	COG1419	protein localization to endoplasmic reticulum
CDV25_RS05280	COG0455	bacterial-type flagellum organization
CDV25_RS05300	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CDV25_RS05300	COG1776	CheC inhibitor of MCP methylation
CDV25_RS05320	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CDV25_RS05325	COG1137	ATPase activity
CDV25_RS05345	COG0745	RESPONSE REGULATOR receiver
CDV25_RS05360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CDV25_RS05365	COG1181	Belongs to the D-alanine--D-alanine ligase family
CDV25_RS05375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CDV25_RS05385	COG1194	a g-specific adenine glycosylase
CDV25_RS05395	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CDV25_RS05415	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CDV25_RS05430	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CDV25_RS05440	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CDV25_RS05450	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CDV25_RS05460	COG0303	'Molybdopterin
CDV25_RS05470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDV25_RS05475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CDV25_RS05485	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CDV25_RS05490	COG2076	Multidrug Resistance protein
CDV25_RS05500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CDV25_RS05510	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CDV25_RS05520	COG2204	response regulator
CDV25_RS05525	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CDV25_RS05545	COG0482	sulfurtransferase activity
CDV25_RS05560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CDV25_RS05575	COG0352	thiamine-phosphate diphosphorylase activity
CDV25_RS05580	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CDV25_RS05585	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CDV25_RS05590	COG0298	carbon dioxide binding
CDV25_RS05620	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CDV25_RS05630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CDV25_RS05630	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CDV25_RS05635	COG0450	alkyl hydroperoxide reductase
CDV25_RS05640	COG0840	transmembrane signaling receptor activity
CDV25_RS05645	COG0133	tryptophan synthase activity
CDV25_RS05665	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CDV25_RS05670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CDV25_RS05675	COG1758	RNA polymerase activity
CDV25_RS05680	COG0528	UMP kinase activity
CDV25_RS05690	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CDV25_RS05690	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CDV25_RS05695	COG2022	thiamine diphosphate biosynthetic process
CDV25_RS05705	COG0217	transcriptional regulatory protein
CDV25_RS05735	COG0215	cysteine-tRNA ligase activity
CDV25_RS05745	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CDV25_RS05750	COG1620	l-lactate permease
CDV25_RS05755	COG0247	lactate metabolic process
CDV25_RS05760	COG1139	Iron-sulfur cluster binding protein
CDV25_RS05765	COG1556	Lactate utilization protein
CDV25_RS05780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CDV25_RS05785	COG0416	fatty acid biosynthetic process
CDV25_RS05790	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CDV25_RS05800	COG0105	UTP biosynthetic process
CDV25_RS05805	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CDV25_RS05810	COG0134	indole-3-glycerol-phosphate synthase activity
CDV25_RS05815	COG0512	Glutamine amidotransferase of anthranilate synthase
CDV25_RS05815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CDV25_RS05830	COG0159	tryptophan synthase activity
CDV25_RS05835	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CDV25_RS05840	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CDV25_RS05845	COG2404	hydrolase activity, acting on ester bonds
CDV25_RS05855	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CDV25_RS05865	COG0859	PFAM glycosyl transferase family 9
CDV25_RS05880	COG0028	Belongs to the TPP enzyme family
CDV25_RS05890	COG0569	domain protein
CDV25_RS05890	COG0475	glutathione-regulated potassium exporter activity
CDV25_RS05895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDV25_RS05905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CDV25_RS05910	COG1183	phosphatidylcholine synthase activity
CDV25_RS05915	COG0688	phosphatidylethanolamine metabolic process
CDV25_RS05920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDV25_RS05925	COG2264	protein methyltransferase activity
CDV25_RS05930	COG0745	RESPONSE REGULATOR receiver
CDV25_RS05935	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CDV25_RS05940	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CDV25_RS05945	COG0840	transmembrane signaling receptor activity
CDV25_RS05955	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CDV25_RS05960	COG0107	imidazoleglycerol-phosphate synthase activity
CDV25_RS05965	COG0500	methyltransferase
CDV25_RS05970	COG3842	ATPase activity
CDV25_RS06000	COG0066	3-isopropylmalate dehydratase activity
CDV25_RS06005	COG0473	3-isopropylmalate dehydrogenase activity
CDV25_RS06010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CDV25_RS06020	COG1663	tetraacyldisaccharide 4'-kinase activity
CDV25_RS06025	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CDV25_RS06030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CDV25_RS06060	COG2861	carbohydrate metabolic process
CDV25_RS06065	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CDV25_RS06070	COG2894	cell division
CDV25_RS06075	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CDV25_RS06090	COG0242	peptide deformylase activity
CDV25_RS06100	COG0740	serine-type endopeptidase activity
CDV25_RS06105	COG0544	peptidyl-prolyl cis-trans isomerase activity
CDV25_RS06110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CDV25_RS06125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CDV25_RS06140	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CDV25_RS06145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CDV25_RS06150	COG0181	hydroxymethylbilane synthase activity
CDV25_RS06160	COG0442	prolyl-tRNA aminoacylation
CDV25_RS06170	COG0142	geranyltranstransferase activity
CDV25_RS06185	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CDV25_RS06190	COG1115	amino acid carrier protein
CDV25_RS06195	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CDV25_RS06200	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CDV25_RS06205	COG1215	transferase activity, transferring glycosyl groups
CDV25_RS06270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CDV25_RS06275	COG0742	ribosomal rna small subunit methyltransferase
CDV25_RS06285	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CDV25_RS06290	COG2050	protein possibly involved in aromatic compounds catabolism
CDV25_RS06290	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CDV25_RS06295	COG2346	COG2346, Truncated hemoglobins
CDV25_RS06320	COG0656	L-ascorbic acid biosynthetic process
CDV25_RS06325	COG1073	alpha beta
CDV25_RS06330	COG0667	Aldo Keto reductase
CDV25_RS06350	COG1988	membrane-bound metal-dependent
CDV25_RS06365	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CDV25_RS06380	COG1136	(ABC) transporter
CDV25_RS06380	COG0577	efflux transmembrane transporter activity
CDV25_RS06385	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CDV25_RS06390	COG0052	Belongs to the universal ribosomal protein uS2 family
CDV25_RS06400	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CDV25_RS06430	COG1213	nucleotidyl transferase
CDV25_RS06450	COG0505	Belongs to the CarA family
CDV25_RS06465	COG4106	trans-aconitate 2-methyltransferase activity
CDV25_RS06475	COG0305	Participates in initiation and elongation during chromosome replication
CDV25_RS06510	COG0673	inositol 2-dehydrogenase activity
CDV25_RS06530	COG3962	Belongs to the TPP enzyme family
CDV25_RS06540	COG1172	Belongs to the binding-protein-dependent transport system permease family
CDV25_RS06555	COG1757	Na H antiporter
CDV25_RS06565	COG1674	ftsk spoiiie
CDV25_RS06590	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CDV25_RS06595	COG1518	maintenance of DNA repeat elements
CDV25_RS06600	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
CDV25_RS06605	COG0137	argininosuccinate synthase activity
CDV25_RS06620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CDV25_RS06665	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CDV25_RS06675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CDV25_RS06680	COG1127	ABC transporter
CDV25_RS06710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CDV25_RS06725	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CDV25_RS06745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CDV25_RS06760	COG0564	pseudouridine synthase activity
CDV25_RS06770	COG0113	porphobilinogen synthase activity
CDV25_RS06775	COG0642	Histidine kinase
CDV25_RS06780	COG0745	RESPONSE REGULATOR receiver
CDV25_RS06800	COG0556	nucleotide-excision repair
CDV25_RS06815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CDV25_RS06820	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CDV25_RS06830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CDV25_RS06835	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CDV25_RS06840	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CDV25_RS06845	COG0187	DNA topoisomerase II activity
CDV25_RS06850	COG0592	DNA-directed DNA polymerase activity
CDV25_RS06855	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CDV25_RS06860	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CDV25_RS06865	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CDV25_RS06875	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CDV25_RS06885	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CDV25_RS06890	COG0783	Belongs to the Dps family
CDV25_RS06895	COG4771	TonB-dependent receptor
CDV25_RS06905	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CDV25_RS06945	COG1459	type II secretion system
CDV25_RS06965	COG0814	amino acid
CDV25_RS06970	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CDV25_RS06975	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CDV25_RS06985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CDV25_RS07000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CDV25_RS07005	COG1832	CoA-binding protein
CDV25_RS07010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CDV25_RS07040	COG1185	polyribonucleotide nucleotidyltransferase activity
CDV25_RS07045	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CDV25_RS07055	COG0811	peptide transport
CDV25_RS07060	COG0848	biopolymer transport protein
CDV25_RS07070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CDV25_RS07075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CDV25_RS07080	COG1749	Flagellar hook protein flgE
CDV25_RS07085	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CDV25_RS07090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CDV25_RS07095	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CDV25_RS07100	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CDV25_RS07105	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CDV25_RS07110	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CDV25_RS07115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CDV25_RS07120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDV25_RS07125	COG0584	glycerophosphoryl diester phosphodiesterase
CDV25_RS07130	COG0542	response to heat
CDV25_RS07135	COG0167	dihydroorotate dehydrogenase activity
CDV25_RS07140	COG0612	Peptidase, M16
CDV25_RS07145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDV25_RS07150	COG1028	Short-chain dehydrogenase reductase Sdr
CDV25_RS07155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CDV25_RS07160	COG0750	zinc metalloprotease
CDV25_RS07170	COG0500	methyltransferase
CDV25_RS07180	COG0310	cobalt ion transport
CDV25_RS07190	COG1122	ATPase activity
CDV25_RS07200	COG3069	C4-dicarboxylate transmembrane transporter activity
CDV25_RS07205	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CDV25_RS07210	COG0708	Exodeoxyribonuclease III
CDV25_RS07225	COG2089	acid synthase
CDV25_RS07270	COG2271	Major facilitator Superfamily
CDV25_RS07325	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CDV25_RS07330	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CDV25_RS07335	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CDV25_RS07340	COG0629	single-stranded DNA binding
CDV25_RS07345	COG0360	Binds together with S18 to 16S ribosomal RNA
CDV25_RS07360	COG0252	asparaginase activity
CDV25_RS07370	COG0484	heat shock protein binding
CDV25_RS07380	COG0730	response to heat
CDV25_RS07395	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CDV25_RS07400	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CDV25_RS07420	COG0748	coenzyme F420 binding
CDV25_RS07435	COG0303	'Molybdopterin
CDV25_RS07450	COG1921	L-seryl-tRNASec selenium transferase activity
CDV25_RS07455	COG0792	nuclease activity
CDV25_RS07460	COG0460	homoserine dehydrogenase
CDV25_RS07485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CDV25_RS07495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CDV25_RS07505	COG0488	(ABC) transporter
CDV25_RS07510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CDV25_RS07510	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CDV25_RS07515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDV25_RS07525	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CDV25_RS07530	COG0747	negative chemotaxis
CDV25_RS07535	COG0601	transmembrane transport
CDV25_RS07540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDV25_RS07555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CDV25_RS07560	COG0018	arginyl-trna synthetase
CDV25_RS07570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CDV25_RS07585	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CDV25_RS07595	COG0488	(ABC) transporter
CDV25_RS07600	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CDV25_RS07615	COG2822	iron ion transport
CDV25_RS07620	COG2837	iron assimilation
CDV25_RS07625	COG0672	)-iron permease
CDV25_RS07645	COG1104	cysteine desulfurase activity
CDV25_RS07650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CDV25_RS07655	COG0280	phosphate acetyltransferase
CDV25_RS07655	COG0281	malic enzyme
CDV25_RS07665	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CDV25_RS07675	COG0439	Biotin carboxylase
CDV25_RS07680	COG0511	ligase activity, forming carbon-carbon bonds
CDV25_RS07685	COG0717	Belongs to the dCTP deaminase family
CDV25_RS07690	COG1289	transmembrane transporter activity
CDV25_RS07695	COG0149	triose-phosphate isomerase activity
CDV25_RS07700	COG1987	bacterial-type flagellum assembly
CDV25_RS07705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CDV25_RS07710	COG0335	large ribosomal subunit rRNA binding
CDV25_RS07720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CDV25_RS07725	COG1837	Belongs to the UPF0109 family
CDV25_RS07730	COG0228	four-way junction DNA binding
CDV25_RS07740	COG0735	belongs to the Fur family
CDV25_RS07750	COG4786	Flagellar basal body rod
CDV25_RS07775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDV25_RS07775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDV25_RS07785	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CDV25_RS07790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CDV25_RS07810	COG2010	Cytochrome c
CDV25_RS07825	COG3278	Belongs to the heme-copper respiratory oxidase family
CDV25_RS07840	COG0343	queuine tRNA-ribosyltransferase activity
CDV25_RS07850	COG1157	protein secretion by the type III secretion system
CDV25_RS07855	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CDV25_RS07885	COG0357	Ribosomal RNA small subunit methyltransferase G
CDV25_RS07895	COG0805	protein transport
CDV25_RS07900	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CDV25_RS07940	COG0829	nickel cation binding
CDV25_RS07945	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CDV25_RS07950	COG0830	nickel cation binding
CDV25_RS07955	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CDV25_RS07965	COG0804	urea catabolic process
CDV25_RS07970	COG0831	urea catabolic process
CDV25_RS07970	COG0832	Belongs to the urease beta subunit family
CDV25_RS07985	COG0629	single-stranded DNA binding
CDV25_RS08015	COG1988	membrane-bound metal-dependent
CDV25_RS08025	COG0573	inorganic phosphate transmembrane transporter activity
CDV25_RS08030	COG0581	inorganic phosphate transmembrane transporter activity
CDV25_RS08035	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CDV25_RS08040	COG0745	RESPONSE REGULATOR receiver
CDV25_RS08045	COG5002	protein histidine kinase activity
CDV25_RS08055	COG0438	transferase activity, transferring glycosyl groups
CDV25_RS08160	COG1129	ABC transporter
CDV25_RS08165	COG1879	ABC-type sugar transport system periplasmic component
CDV25_RS08170	COG1418	mRNA catabolic process
CDV25_RS08185	COG4206	TonB-dependent receptor
CDV25_RS08210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CDV25_RS08215	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CDV25_RS08230	COG0250	Participates in transcription elongation, termination and antitermination
CDV25_RS08235	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CDV25_RS08240	COG0081	regulation of translation
CDV25_RS08245	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CDV25_RS08250	COG0222	ribosome binding
CDV25_RS08255	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CDV25_RS08255	COG0085	RNA polymerase activity
CDV25_RS08260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CDV25_RS08265	COG0049	tRNA binding
CDV25_RS08270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CDV25_RS08275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CDV25_RS08285	COG0537	adenosine 5'-monophosphoramidase activity
CDV25_RS08290	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CDV25_RS08295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDV25_RS08295	COG0072	phenylalanine-tRNA ligase activity
CDV25_RS08300	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CDV25_RS08305	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CDV25_RS08310	COG0539	negative regulation of cytoplasmic translation
CDV25_RS08310	COG1185	polyribonucleotide nucleotidyltransferase activity
CDV25_RS08320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CDV25_RS08350	COG1742	UPF0060 membrane protein
CDV25_RS08355	COG0730	response to heat
CDV25_RS08360	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CDV25_RS08365	COG3842	ATPase activity
CDV25_RS08375	COG1840	ABC-type Fe3 transport system, periplasmic component
CDV25_RS08410	COG1012	belongs to the aldehyde dehydrogenase family
CDV25_RS08415	COG4783	chaperone-mediated protein folding
CDV25_RS08420	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CDV25_RS08425	COG1027	Aspartate ammonia-lyase
CDV25_RS08440	COG1054	Belongs to the UPF0176 family
CDV25_RS08445	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CDV25_RS08470	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CDV25_RS08475	COG2217	Heavy metal translocating P-type atpase
CDV25_RS08485	COG0163	prenyltransferase activity
CDV25_RS08490	COG2855	membrane
CDV25_RS08495	COG0583	DNA-binding transcription factor activity
CDV25_RS08535	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CDV25_RS08545	COG0739	heme binding
CDV25_RS08550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CDV25_RS08555	COG0443	Heat shock 70 kDa protein
CDV25_RS08565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDV25_RS08575	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CDV25_RS08590	COG2833	Protein of unknown function (DUF455)
CDV25_RS08595	COG1968	undecaprenyl-diphosphatase activity
CDV25_RS08600	COG0439	Biotin carboxylase
CDV25_RS08605	COG2255	four-way junction helicase activity
CDV25_RS08610	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CDV25_RS08630	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CDV25_RS08635	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CDV25_RS08640	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CDV25_RS08665	COG1204	response to ionizing radiation
CDV25_RS08710	COG0732	type I restriction modification DNA specificity domain
CDV25_RS08715	COG1733	regulation of RNA biosynthetic process
CDV25_RS08735	COG2249	NAD(P)H dehydrogenase (quinone) activity
CDV25_RS08755	COG1126	abc transporter atp-binding protein
CDV25_RS08765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDV25_RS08770	COG0626	cystathionine gamma-synthase activity
CDV25_RS08780	COG0445	tRNA wobble uridine modification
CDV25_RS08785	COG2356	endonuclease I
CDV25_RS08795	COG0284	orotidine-5'-phosphate decarboxylase activity
CDV25_RS08815	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CDV25_RS08840	COG0574	Belongs to the PEP-utilizing enzyme family
CDV25_RS08840	COG3848	Pyruvate phosphate dikinase
CDV25_RS08845	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CDV25_RS08860	COG1213	nucleotidyl transferase
CDV25_RS08870	COG0725	ABC transporter, periplasmic molybdate-binding protein
CDV25_RS08875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CDV25_RS08880	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CDV25_RS08880	COG0506	proline dehydrogenase activity
CDV25_RS08880	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CDV25_RS08885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CDV25_RS08895	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CDV25_RS08900	COG1295	ribonuclease BN
CDV25_RS08905	COG1253	flavin adenine dinucleotide binding
CDV25_RS08915	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CDV25_RS08925	COG2056	Na+-H+ antiporter family
CDV25_RS08930	COG0517	IMP dehydrogenase activity
CDV25_RS08930	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CDV25_RS08935	COG4166	transmembrane transport
CDV25_RS08945	COG4239	(ABC) transporter, permease
CDV25_RS08950	COG4172	Belongs to the ABC transporter superfamily
CDV25_RS08965	COG1666	GTP binding
CDV25_RS08975	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CDV25_RS08980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CDV25_RS08995	COG2890	protein-(glutamine-N5) methyltransferase activity
CDV25_RS09000	COG0501	Belongs to the peptidase M48B family
CDV25_RS09010	COG1496	oxidoreductase activity
CDV25_RS09015	COG0124	histidyl-tRNA synthetase
CDV25_RS09025	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CDV25_RS09045	COG0436	Aminotransferase
CDV25_RS09050	COG2217	Heavy metal translocating P-type atpase
CDV25_RS09060	COG0803	Belongs to the bacterial solute-binding protein 9 family
CDV25_RS09065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CDV25_RS09075	COG0698	ribose 5-phosphate isomerase
CDV25_RS09085	COG0681	Belongs to the peptidase S26 family
CDV25_RS09090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CDV25_RS09105	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CDV25_RS09105	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CDV25_RS09120	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CDV25_RS09125	COG0799	negative regulation of ribosome biogenesis
CDV25_RS09145	COG2249	NAD(P)H dehydrogenase (quinone) activity
CDV25_RS09200	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CDV25_RS09205	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CDV25_RS09210	COG3150	esterase
CDV25_RS09220	COG0733	neurotransmitter:sodium symporter activity
CDV25_RS09230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CDV25_RS09235	COG2011	ABC-type metal ion transport system permease component
CDV25_RS09240	COG1464	Belongs to the NlpA lipoprotein family
CDV25_RS09245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CDV25_RS09290	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CDV25_RS09295	COG0131	Imidazoleglycerol-phosphate dehydratase
CDV25_RS09300	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CDV25_RS09305	COG1376	ErfK ybiS ycfS ynhG family protein
CDV25_RS09320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CDV25_RS09330	COG0195	Participates in both transcription termination and antitermination
CDV25_RS09335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDV25_RS09340	COG0849	cell division
CDV25_RS09345	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CDV25_RS09350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CDV25_RS09410	COG1058	Belongs to the CinA family
CDV25_RS09410	COG1546	Belongs to the CinA family
CDV25_RS09450	COG1196	nuclear chromosome segregation
CDV25_RS09450	COG1674	ftsk spoiiie
CDV25_RS09465	COG0006	proline dipeptidase activity
CDV25_RS09470	COG0840	transmembrane signaling receptor activity
CDV25_RS09490	COG2031	fatty acid transporter
CDV25_RS09495	COG2610	gluconate transmembrane transporter activity
CDV25_RS09500	COG1028	Short-chain dehydrogenase reductase Sdr
CDV25_RS09505	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CDV25_RS09510	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CDV25_RS09515	COG0183	Belongs to the thiolase family
CDV25_RS09530	COG0686	Belongs to the AlaDH PNT family
CDV25_RS09535	COG0733	neurotransmitter:sodium symporter activity
CDV25_RS09550	COG0326	Molecular chaperone. Has ATPase activity
CDV25_RS09585	COG0134	indole-3-glycerol-phosphate synthase activity
CDV25_RS09595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CDV25_RS09635	COG0237	dephospho-CoA kinase activity
CDV25_RS09640	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CDV25_RS09655	COG2195	Cleaves the N-terminal amino acid of tripeptides
CDV25_RS09665	COG1294	oxidase, subunit
CDV25_RS09670	COG1271	oxidase subunit
CDV25_RS09690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CDV25_RS09695	COG0504	CTP synthase activity
CDV25_RS09700	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CDV25_RS09700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CDV25_RS09720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CDV25_RS09730	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CDV25_RS09740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CDV25_RS09745	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CDV25_RS09750	COG0727	PFAM Uncharacterised protein family (UPF0153)
CDV25_RS09760	COG4221	oxidoreductase activity
CDV25_RS09765	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CDV25_RS09770	COG0306	phosphate transporter
CDV25_RS09775	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CDV25_RS09780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CDV25_RS09785	COG0752	glycyl-tRNA synthetase alpha subunit
CDV25_RS09790	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CDV25_RS09800	COG1519	Transferase
CDV25_RS09805	COG0564	pseudouridine synthase activity
CDV25_RS09820	COG0140	phosphoribosyl-ATP diphosphatase activity
CDV25_RS09820	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CDV25_RS09830	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CDV25_RS09840	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CDV25_RS09855	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CDV25_RS09860	COG0497	DNA recombination
CDV25_RS09875	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CDV25_RS09880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CDV25_RS09885	COG0180	Tryptophanyl-tRNA synthetase
CDV25_RS09895	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CDV25_RS09900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CDV25_RS09925	COG3504	Conjugal transfer protein
CDV25_RS09970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CDV25_RS10020	COG1598	PFAM Uncharacterised protein family UPF0150
CDV25_RS10035	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CDV25_RS10055	COG0629	single-stranded DNA binding