locus-tag	class	description
HCN_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HCN_RS00015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HCN_RS00020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCN_RS00025	COG0300	oxidoreductase activity
HCN_RS00040	COG2855	membrane
HCN_RS00060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HCN_RS00065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HCN_RS00070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HCN_RS00080	COG1028	Short-chain dehydrogenase reductase Sdr
HCN_RS00085	COG3959	Transketolase, thiamine diphosphate binding domain
HCN_RS00090	COG3958	Transketolase
HCN_RS00100	COG0318	PFAM AMP-dependent synthetase and ligase
HCN_RS00160	COG1064	alcohol dehydrogenase
HCN_RS00170	COG0730	response to heat
HCN_RS00180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCN_RS00185	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HCN_RS00230	COG4771	TonB-dependent receptor
HCN_RS00235	COG1419	protein localization to endoplasmic reticulum
HCN_RS00240	COG0455	bacterial-type flagellum organization
HCN_RS00250	COG1191	sigma factor activity
HCN_RS00255	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HCN_RS00260	COG1776	CheC inhibitor of MCP methylation
HCN_RS00260	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HCN_RS00265	COG0492	ferredoxin-NADP+ reductase activity
HCN_RS00275	COG0840	transmembrane signaling receptor activity
HCN_RS00290	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HCN_RS00300	COG1271	oxidase subunit
HCN_RS00305	COG1294	oxidase, subunit
HCN_RS00310	COG0814	amino acid
HCN_RS00315	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HCN_RS00325	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HCN_RS00355	COG2217	Heavy metal translocating P-type atpase
HCN_RS00360	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HCN_RS00365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HCN_RS00370	COG0746	molybdenum cofactor guanylyltransferase activity
HCN_RS00375	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HCN_RS00385	COG0850	regulation of cytokinetic process
HCN_RS00390	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HCN_RS00400	COG0083	homoserine kinase activity
HCN_RS00410	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HCN_RS00420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCN_RS00425	COG1663	tetraacyldisaccharide 4'-kinase activity
HCN_RS00430	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HCN_RS00435	COG0723	plastoquinol--plastocyanin reductase activity
HCN_RS00440	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HCN_RS00450	COG2353	YceI-like domain
HCN_RS00455	COG1136	(ABC) transporter
HCN_RS00465	COG1696	Membrane protein involved in D-alanine export
HCN_RS00490	COG4786	Flagellar basal body rod
HCN_RS00495	COG2860	membrane
HCN_RS00500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HCN_RS00505	COG0802	atpase or kinase
HCN_RS00510	COG1137	ATPase activity
HCN_RS00515	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HCN_RS00530	COG0052	Belongs to the universal ribosomal protein uS2 family
HCN_RS00535	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HCN_RS00540	COG0367	asparagine synthase
HCN_RS00565	COG1696	Membrane protein involved in D-alanine export
HCN_RS00575	COG0280	phosphate acetyltransferase
HCN_RS00575	COG0281	malic enzyme
HCN_RS00580	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HCN_RS00585	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HCN_RS00595	COG4786	Flagellar basal body rod
HCN_RS00605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HCN_RS00605	COG1333	cytochrome c biogenesis protein
HCN_RS00615	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HCN_RS00625	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HCN_RS00630	COG0287	Prephenate dehydrogenase
HCN_RS00635	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCN_RS00640	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HCN_RS00645	COG0612	Peptidase, M16
HCN_RS00685	COG0134	indole-3-glycerol-phosphate synthase activity
HCN_RS00690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCN_RS00740	COG0438	transferase activity, transferring glycosyl groups
HCN_RS00745	COG1216	Glycosyl transferase, family 2
HCN_RS00760	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HCN_RS00770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCN_RS00775	COG0247	lactate metabolic process
HCN_RS00795	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HCN_RS00800	COG1338	Plays a role in the flagellum-specific transport system
HCN_RS00805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCN_RS00820	COG0328	RNA-DNA hybrid ribonuclease activity
HCN_RS00825	COG0571	ribonuclease III activity
HCN_RS00830	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HCN_RS00835	COG0154	amidase activity
HCN_RS00840	COG0517	IMP dehydrogenase activity
HCN_RS00840	COG0516	GMP reductase activity
HCN_RS00860	COG0587	DNA-directed DNA polymerase activity
HCN_RS00865	COG0195	Participates in both transcription termination and antitermination
HCN_RS00870	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HCN_RS00875	COG0006	proline dipeptidase activity
HCN_RS00890	COG0335	large ribosomal subunit rRNA binding
HCN_RS00895	COG0336	Belongs to the RNA methyltransferase TrmD family
HCN_RS00910	COG0228	four-way junction DNA binding
HCN_RS00915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HCN_RS00920	COG0735	belongs to the Fur family
HCN_RS00930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCN_RS00935	COG0525	valine-tRNA ligase activity
HCN_RS00940	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HCN_RS00960	COG0727	PFAM Uncharacterised protein family (UPF0153)
HCN_RS00975	COG0708	Exodeoxyribonuclease III
HCN_RS00995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HCN_RS01000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HCN_RS01005	COG3585	molybdate ion transport
HCN_RS01020	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HCN_RS01040	COG1058	Belongs to the CinA family
HCN_RS01040	COG1546	Belongs to the CinA family
HCN_RS01065	COG1420	regulation of RNA biosynthetic process
HCN_RS01070	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HCN_RS01080	COG0443	Heat shock 70 kDa protein
HCN_RS01085	COG0252	asparaginase activity
HCN_RS01090	COG3069	C4-dicarboxylate transmembrane transporter activity
HCN_RS01095	COG0753	catalase activity
HCN_RS01105	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HCN_RS01150	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HCN_RS01160	COG4771	TonB-dependent receptor
HCN_RS01165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCN_RS01170	COG1120	ATPase activity
HCN_RS01275	COG0673	inositol 2-dehydrogenase activity
HCN_RS01285	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HCN_RS01300	COG0148	phosphopyruvate hydratase activity
HCN_RS01305	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HCN_RS01310	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HCN_RS01315	COG0628	permease
HCN_RS01320	COG2192	nodulation
HCN_RS01325	COG2192	nodulation
HCN_RS01345	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HCN_RS01350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HCN_RS01360	COG1519	Transferase
HCN_RS01365	COG0564	pseudouridine synthase activity
HCN_RS01400	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HCN_RS01415	COG0527	aspartate kinase activity
HCN_RS01420	COG0494	nUDIX hydrolase
HCN_RS01425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCN_RS01430	COG0438	transferase activity, transferring glycosyl groups
HCN_RS01460	COG1487	ribonuclease activity
HCN_RS01485	COG0826	peptidase U32
HCN_RS01490	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HCN_RS01515	COG1556	Lactate utilization protein
HCN_RS01520	COG1139	Iron-sulfur cluster binding protein
HCN_RS01525	COG0247	lactate metabolic process
HCN_RS01540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCN_RS01550	COG1233	COG1233 Phytoene dehydrogenase and related
HCN_RS01560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HCN_RS01560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HCN_RS01570	COG1216	Glycosyl transferase, family 2
HCN_RS01580	COG0418	dihydroorotase activity
HCN_RS01590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCN_RS01600	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HCN_RS01610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HCN_RS01620	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCN_RS01625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCN_RS01630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HCN_RS01645	COG0101	tRNA pseudouridine synthase activity
HCN_RS01670	COG1185	polyribonucleotide nucleotidyltransferase activity
HCN_RS01675	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCN_RS01690	COG1757	Na H antiporter
HCN_RS01695	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HCN_RS01700	COG0552	protein localization to endoplasmic reticulum
HCN_RS01715	COG1418	mRNA catabolic process
HCN_RS01730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HCN_RS01740	COG0835	chemotaxis
HCN_RS01740	COG0784	Response regulator, receiver
HCN_RS01745	COG1183	phosphatidylcholine synthase activity
HCN_RS01755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCN_RS01760	COG2264	protein methyltransferase activity
HCN_RS01765	COG0745	RESPONSE REGULATOR receiver
HCN_RS01770	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HCN_RS01790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HCN_RS01800	COG1758	RNA polymerase activity
HCN_RS01805	COG0528	UMP kinase activity
HCN_RS01815	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HCN_RS01820	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCN_RS01820	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCN_RS01825	COG0779	Required for maturation of 30S ribosomal subunits
HCN_RS01830	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HCN_RS01835	COG0343	queuine tRNA-ribosyltransferase activity
HCN_RS01840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCN_RS01845	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HCN_RS01850	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCN_RS01855	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HCN_RS01870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCN_RS01890	COG0129	dihydroxy-acid dehydratase activity
HCN_RS01905	COG0174	glutamine synthetase
HCN_RS01910	COG3848	Pyruvate phosphate dikinase
HCN_RS01910	COG0574	Belongs to the PEP-utilizing enzyme family
HCN_RS01920	COG0180	Tryptophanyl-tRNA synthetase
HCN_RS01925	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HCN_RS01935	COG0674	pyruvate-flavodoxin oxidoreductase activity
HCN_RS01940	COG1013	pyruvate-flavodoxin oxidoreductase activity
HCN_RS01945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCN_RS01955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HCN_RS01965	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HCN_RS01970	COG0629	single-stranded DNA binding
HCN_RS01975	COG0360	Binds together with S18 to 16S ribosomal RNA
HCN_RS01980	COG1466	dna polymerase III delta subunit
HCN_RS02000	COG0752	glycyl-tRNA synthetase alpha subunit
HCN_RS02015	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HCN_RS02020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HCN_RS02035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HCN_RS02060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HCN_RS02075	COG1937	Protein conserved in bacteria
HCN_RS02080	COG0606	chelatase, subunit chli
HCN_RS02085	COG0242	peptide deformylase activity
HCN_RS02095	COG0740	serine-type endopeptidase activity
HCN_RS02100	COG0544	peptidyl-prolyl cis-trans isomerase activity
HCN_RS02105	COG1157	protein secretion by the type III secretion system
HCN_RS02115	COG2050	protein possibly involved in aromatic compounds catabolism
HCN_RS02115	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HCN_RS02120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HCN_RS02130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCN_RS02130	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCN_RS02140	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HCN_RS02150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCN_RS02155	COG2176	DNA-directed DNA polymerase activity
HCN_RS02160	COG2890	protein-(glutamine-N5) methyltransferase activity
HCN_RS02165	COG0501	Belongs to the peptidase M48B family
HCN_RS02170	COG0504	CTP synthase activity
HCN_RS02180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCN_RS02185	COG0825	malonyl-CoA metabolic process
HCN_RS02190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCN_RS02195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCN_RS02200	COG1028	Short-chain dehydrogenase reductase Sdr
HCN_RS02205	COG4953	penicillin-binding protein 1C
HCN_RS02210	COG2373	Large extracellular alpha-helical protein
HCN_RS02215	COG0564	pseudouridine synthase activity
HCN_RS02235	COG0573	inorganic phosphate transmembrane transporter activity
HCN_RS02240	COG0581	inorganic phosphate transmembrane transporter activity
HCN_RS02245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCN_RS02260	COG5002	protein histidine kinase activity
HCN_RS02290	COG0471	metal ion transport
HCN_RS02300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HCN_RS02320	COG0372	Belongs to the citrate synthase family
HCN_RS02325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HCN_RS02330	COG0193	aminoacyl-tRNA hydrolase activity
HCN_RS02340	COG0356	it plays a direct role in the translocation of protons across the membrane
HCN_RS02345	COG0352	thiamine-phosphate diphosphorylase activity
HCN_RS02380	COG0489	protein tyrosine kinase activity
HCN_RS02395	COG0019	diaminopimelate decarboxylase activity
HCN_RS02400	COG0077	Prephenate dehydratase
HCN_RS02400	COG1605	Chorismate mutase
HCN_RS02415	COG2267	carboxylic ester hydrolase activity
HCN_RS02425	COG1960	acyl-CoA dehydrogenase activity
HCN_RS02435	COG0585	pseudouridine synthase activity
HCN_RS02440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCN_RS02455	COG0484	heat shock protein binding
HCN_RS02465	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HCN_RS02470	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HCN_RS02470	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HCN_RS02475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCN_RS02480	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HCN_RS02495	COG0450	alkyl hydroperoxide reductase
HCN_RS02500	COG3162	membrane
HCN_RS02505	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCN_RS02515	COG0556	nucleotide-excision repair
HCN_RS02530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HCN_RS02545	COG0736	holo-[acyl-carrier-protein] synthase activity
HCN_RS02550	COG0799	negative regulation of ribosome biogenesis
HCN_RS02555	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HCN_RS02560	COG0864	Transcriptional regulator
HCN_RS02565	COG0811	peptide transport
HCN_RS02570	COG0848	biopolymer transport protein
HCN_RS02580	COG1126	abc transporter atp-binding protein
HCN_RS02585	COG0765	amino acid transport
HCN_RS02625	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HCN_RS02630	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HCN_RS02635	COG0142	geranyltranstransferase activity
HCN_RS02645	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HCN_RS02650	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HCN_RS02685	COG2833	Protein of unknown function (DUF455)
HCN_RS02695	COG0126	phosphoglycerate kinase activity
HCN_RS02730	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HCN_RS02735	COG0298	carbon dioxide binding
HCN_RS02745	COG0409	Hydrogenase expression formation protein
HCN_RS02755	COG0309	Hydrogenase expression formation protein (HypE)
HCN_RS02760	COG0724	RNA recognition motif
HCN_RS02770	COG0653	protein targeting
HCN_RS02775	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HCN_RS02785	COG0512	Glutamine amidotransferase of anthranilate synthase
HCN_RS02785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCN_RS02795	COG0359	binds to the 23S rRNA
HCN_RS02800	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HCN_RS02805	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HCN_RS02820	COG0204	Acyl-transferase
HCN_RS02820	COG0318	PFAM AMP-dependent synthetase and ligase
HCN_RS02825	COG0051	transcription antitermination factor activity, RNA binding
HCN_RS02830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HCN_RS02835	COG0088	Forms part of the polypeptide exit tunnel
HCN_RS02840	COG0089	rRNA binding
HCN_RS02845	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HCN_RS02850	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HCN_RS02855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HCN_RS02860	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HCN_RS02865	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HCN_RS02870	COG0255	Belongs to the universal ribosomal protein uL29 family
HCN_RS02875	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HCN_RS02880	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HCN_RS02885	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HCN_RS02890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HCN_RS02895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HCN_RS02900	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HCN_RS02905	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HCN_RS02910	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HCN_RS02915	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HCN_RS02920	COG0200	Binds to the 23S rRNA
HCN_RS02925	COG0201	protein transport
HCN_RS02930	COG0024	Methionine aminopeptidase
HCN_RS02935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HCN_RS02945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HCN_RS02950	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HCN_RS02955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HCN_RS02960	COG0202	RNA polymerase activity
HCN_RS02965	COG0203	ribosomal protein L17
HCN_RS02970	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCN_RS03000	COG3383	formate dehydrogenase (NAD+) activity
HCN_RS03005	COG0437	4 iron, 4 sulfur cluster binding
HCN_RS03015	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HCN_RS03025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCN_RS03045	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HCN_RS03055	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HCN_RS03085	COG2226	methyltransferase
HCN_RS03110	COG0783	Belongs to the Dps family
HCN_RS03115	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCN_RS03135	COG1215	transferase activity, transferring glycosyl groups
HCN_RS03145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCN_RS03155	COG1007	ATP synthesis coupled electron transport
HCN_RS03165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HCN_RS03170	COG0713	ATP synthesis coupled electron transport
HCN_RS03175	COG0839	Belongs to the complex I subunit 6 family
HCN_RS03180	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCN_RS03185	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HCN_RS03205	COG0649	NAD binding
HCN_RS03210	COG0649	NAD binding
HCN_RS03215	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCN_RS03230	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HCN_RS03240	COG1160	GTP binding
HCN_RS03255	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HCN_RS03255	COG0140	phosphoribosyl-ATP diphosphatase activity
HCN_RS03260	COG0330	HflC and HflK could
HCN_RS03270	COG0488	(ABC) transporter
HCN_RS03280	COG1674	ftsk spoiiie
HCN_RS03295	COG2201	protein-glutamate methylesterase activity
HCN_RS03325	COG0357	Ribosomal RNA small subunit methyltransferase G
HCN_RS03330	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HCN_RS03335	COG0805	protein transport
HCN_RS03340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCN_RS03345	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HCN_RS03355	COG1408	metallophosphoesterase
HCN_RS03360	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HCN_RS03365	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HCN_RS03370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HCN_RS03375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HCN_RS03380	COG0233	cytoplasmic translational termination
HCN_RS03385	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HCN_RS03410	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HCN_RS03415	COG1987	bacterial-type flagellum assembly
HCN_RS03420	COG1047	Peptidyl-prolyl cis-trans
HCN_RS03430	COG2885	chlorophyll binding
HCN_RS03435	COG0823	Involved in the tonB-independent uptake of proteins
HCN_RS03445	COG0848	biopolymer transport protein
HCN_RS03450	COG0811	peptide transport
HCN_RS03455	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HCN_RS03460	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HCN_RS03465	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HCN_RS03470	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HCN_RS03475	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCN_RS03480	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HCN_RS03490	COG1475	DNA binding
HCN_RS03495	COG1192	Involved in chromosome partitioning
HCN_RS03505	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HCN_RS03510	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HCN_RS03515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCN_RS03525	COG1696	Membrane protein involved in D-alanine export
HCN_RS03535	COG1696	Membrane protein involved in D-alanine export
HCN_RS03540	COG0747	negative chemotaxis
HCN_RS03545	COG0601	transmembrane transport
HCN_RS03550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCN_RS03560	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HCN_RS03585	COG0463	Glycosyl transferase, family 2
HCN_RS03590	COG0840	transmembrane signaling receptor activity
HCN_RS03625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCN_RS03635	COG2346	COG2346, Truncated hemoglobins
HCN_RS03640	COG2819	hydrolase of the alpha beta superfamily
HCN_RS03660	COG3043	anaerobic respiration
HCN_RS03665	COG0348	domain, Protein
HCN_RS03670	COG0437	4 iron, 4 sulfur cluster binding
HCN_RS03675	COG0243	molybdopterin cofactor binding
HCN_RS03685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HCN_RS03690	COG0756	dUTP diphosphatase activity
HCN_RS03705	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HCN_RS03710	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HCN_RS03740	COG0217	transcriptional regulatory protein
HCN_RS03750	COG0113	porphobilinogen synthase activity
HCN_RS03755	COG0642	Histidine kinase
HCN_RS03760	COG0745	RESPONSE REGULATOR receiver
HCN_RS03775	COG0037	tRNA processing
HCN_RS03785	COG2814	Major facilitator Superfamily
HCN_RS03790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HCN_RS03800	COG0793	Belongs to the peptidase S41A family
HCN_RS03805	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HCN_RS03810	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCN_RS03815	COG0047	phosphoribosylformylglycinamidine synthase activity
HCN_RS03825	COG0204	Acyl-transferase
HCN_RS03840	COG0124	histidyl-tRNA synthetase
HCN_RS03865	COG3959	Transketolase, thiamine diphosphate binding domain
HCN_RS03870	COG3959	Transketolase, thiamine diphosphate binding domain
HCN_RS03875	COG3958	Transketolase
HCN_RS03880	COG4221	oxidoreductase activity
HCN_RS03890	COG4106	trans-aconitate 2-methyltransferase activity
HCN_RS03920	COG1028	Short-chain dehydrogenase reductase Sdr
HCN_RS03935	COG0859	PFAM glycosyl transferase family 9
HCN_RS03940	COG0167	dihydroorotate dehydrogenase activity
HCN_RS03945	COG0612	Peptidase, M16
HCN_RS03950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCN_RS03955	COG1028	Short-chain dehydrogenase reductase Sdr
HCN_RS03960	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HCN_RS03975	COG1115	amino acid carrier protein
HCN_RS03985	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HCN_RS03990	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HCN_RS03995	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HCN_RS04000	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HCN_RS04005	COG0811	peptide transport
HCN_RS04010	COG0848	biopolymer transport protein
HCN_RS04025	COG0594	ribonuclease P activity
HCN_RS04035	COG0706	membrane insertase activity
HCN_RS04045	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HCN_RS04055	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HCN_RS04060	COG1815	bacterial-type flagellum-dependent cell motility
HCN_RS04065	COG1558	bacterial-type flagellum-dependent cell motility
HCN_RS04070	COG1677	Flagellar hook-basal body complex protein FliE
HCN_RS04085	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HCN_RS04125	COG1028	Short-chain dehydrogenase reductase Sdr
HCN_RS04130	COG0534	Mate efflux family protein
HCN_RS04140	COG0537	adenosine 5'-monophosphoramidase activity
HCN_RS04145	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HCN_RS04150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCN_RS04150	COG0072	phenylalanine-tRNA ligase activity
HCN_RS04155	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HCN_RS04175	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HCN_RS04180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HCN_RS04185	COG4753	response regulator
HCN_RS04185	COG2207	Transcriptional regulator
HCN_RS04200	COG0322	excinuclease ABC activity
HCN_RS04215	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HCN_RS04220	COG1322	Protein conserved in bacteria
HCN_RS04225	COG0315	cyclic pyranopterin monophosphate synthase activity
HCN_RS04230	COG0521	Mo-molybdopterin cofactor biosynthetic process
HCN_RS04240	COG0314	molybdopterin synthase activity
HCN_RS04250	COG0303	'Molybdopterin
HCN_RS04255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCN_RS04260	COG0586	Pfam SNARE associated Golgi protein
HCN_RS04265	COG0288	reversible hydration of carbon dioxide
HCN_RS04270	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HCN_RS04275	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HCN_RS04280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCN_RS04285	COG0284	orotidine-5'-phosphate decarboxylase activity
HCN_RS04290	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HCN_RS04305	COG0133	tryptophan synthase activity
HCN_RS04320	COG0302	gtp cyclohydrolase
HCN_RS04340	COG0745	RESPONSE REGULATOR receiver
HCN_RS04345	COG0642	Histidine kinase
HCN_RS04350	COG0305	Participates in initiation and elongation during chromosome replication
HCN_RS04360	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HCN_RS04385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HCN_RS04390	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HCN_RS04445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HCN_RS04450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCN_RS04450	COG0551	DNA topoisomerase type I activity
HCN_RS04455	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HCN_RS04465	COG1739	Uncharacterized protein family UPF0029
HCN_RS04470	COG1981	membrane
HCN_RS04475	COG0165	Argininosuccinate lyase
HCN_RS04485	COG0579	oxidoreductase
HCN_RS04490	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HCN_RS04510	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HCN_RS04515	COG0442	prolyl-tRNA aminoacylation
HCN_RS04520	COG0181	hydroxymethylbilane synthase activity
HCN_RS04525	COG1295	ribonuclease BN
HCN_RS04530	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HCN_RS04535	COG1570	exodeoxyribonuclease VII activity
HCN_RS04545	COG0709	Synthesizes selenophosphate from selenide and ATP
HCN_RS04555	COG1049	propionate catabolic process, 2-methylcitrate cycle
HCN_RS04565	COG1217	gtp-binding protein TYPA
HCN_RS04570	COG0778	Nitroreductase
HCN_RS04575	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCN_RS04590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HCN_RS04595	COG0268	Binds directly to 16S ribosomal RNA
HCN_RS04600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCN_RS04605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HCN_RS04630	COG2056	Na+-H+ antiporter family
HCN_RS04645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HCN_RS04650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HCN_RS04655	COG1253	flavin adenine dinucleotide binding
HCN_RS04660	COG0306	phosphate transporter
HCN_RS04690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCN_RS04700	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HCN_RS04705	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HCN_RS04715	COG0791	NLP P60 protein
HCN_RS04725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCN_RS04725	COG0574	Belongs to the PEP-utilizing enzyme family
HCN_RS04730	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCN_RS04740	COG0352	thiamine-phosphate diphosphorylase activity
HCN_RS04755	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HCN_RS04765	COG0731	radical SAM domain protein
HCN_RS04770	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HCN_RS04775	COG0157	Belongs to the NadC ModD family
HCN_RS04785	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HCN_RS04790	COG2885	chlorophyll binding
HCN_RS04815	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HCN_RS04820	COG2957	Belongs to the agmatine deiminase family
HCN_RS04830	COG4974	Belongs to the 'phage' integrase family
HCN_RS04850	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HCN_RS04855	COG0439	Biotin carboxylase
HCN_RS04860	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HCN_RS04860	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HCN_RS04865	COG2022	thiamine diphosphate biosynthetic process
HCN_RS04870	COG2226	methyltransferase
HCN_RS04895	COG1696	Membrane protein involved in D-alanine export
HCN_RS04905	COG0577	efflux transmembrane transporter activity
HCN_RS04905	COG1136	(ABC) transporter
HCN_RS04910	COG0577	efflux transmembrane transporter activity
HCN_RS04910	COG1136	(ABC) transporter
HCN_RS04915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCN_RS04980	COG0124	histidyl-tRNA synthetase
HCN_RS04990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCN_RS04995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCN_RS05005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HCN_RS05010	COG0784	Response regulator, receiver
HCN_RS05010	COG0835	chemotaxis
HCN_RS05015	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HCN_RS05025	COG0563	adenylate kinase activity
HCN_RS05045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCN_RS05055	COG0513	Belongs to the DEAD box helicase family
HCN_RS05060	COG0785	Cytochrome C biogenesis protein
HCN_RS05065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCN_RS05070	COG0668	transmembrane transport
HCN_RS05075	COG0402	S-adenosylhomocysteine deaminase activity
HCN_RS05080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCN_RS05100	COG1121	(ABC) transporter
HCN_RS05105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCN_RS05115	COG0792	nuclease activity
HCN_RS05120	COG0460	homoserine dehydrogenase
HCN_RS05125	COG0436	Aminotransferase
HCN_RS05140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCN_RS05145	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HCN_RS05150	COG0254	rRNA binding
HCN_RS05175	COG0326	Molecular chaperone. Has ATPase activity
HCN_RS05200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HCN_RS05205	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HCN_RS05210	COG0163	prenyltransferase activity
HCN_RS05235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HCN_RS05255	COG0765	amino acid transport
HCN_RS05260	COG0765	amino acid transport
HCN_RS05265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCN_RS05270	COG1126	abc transporter atp-binding protein
HCN_RS05300	COG0133	tryptophan synthase activity
HCN_RS05305	COG0159	tryptophan synthase activity
HCN_RS05320	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCN_RS05330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HCN_RS05330	COG0519	Catalyzes the synthesis of GMP from XMP
HCN_RS05355	COG0617	tRNA 3'-terminal CCA addition
HCN_RS05360	COG0644	oxidoreductase
HCN_RS05365	COG1454	alcohol dehydrogenase
HCN_RS05370	COG0028	Belongs to the TPP enzyme family
HCN_RS05370	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
HCN_RS05395	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HCN_RS05405	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HCN_RS05410	COG0574	Belongs to the PEP-utilizing enzyme family
HCN_RS05410	COG3848	Pyruvate phosphate dikinase
HCN_RS05415	COG0500	methyltransferase
HCN_RS05420	COG0706	membrane insertase activity
HCN_RS05435	COG1749	Flagellar hook protein flgE
HCN_RS05445	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HCN_RS05460	COG0237	dephospho-CoA kinase activity
HCN_RS05465	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HCN_RS05485	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HCN_RS05500	COG0788	formyltetrahydrofolate deformylase activity
HCN_RS05505	COG0616	signal peptide processing
HCN_RS05510	COG0251	oxidation-reduction process
HCN_RS05525	COG5016	pyruvate
HCN_RS05525	COG0511	ligase activity, forming carbon-carbon bonds
HCN_RS05530	COG3022	response to hydroperoxide
HCN_RS05545	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HCN_RS05550	COG0750	zinc metalloprotease
HCN_RS05555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HCN_RS05560	COG0598	Magnesium transport protein CorA
HCN_RS05565	COG0861	Integral membrane protein TerC family
HCN_RS05610	COG4172	Belongs to the ABC transporter superfamily
HCN_RS05615	COG4239	(ABC) transporter, permease
HCN_RS05625	COG4174	ABC transporter (Permease)
HCN_RS05630	COG2879	small protein
HCN_RS05645	COG1966	Carbon starvation protein
HCN_RS05655	COG0134	indole-3-glycerol-phosphate synthase activity
HCN_RS05660	COG2843	Capsule synthesis protein
HCN_RS05670	COG2703	oxygen carrier activity
HCN_RS05675	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HCN_RS05680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCN_RS05685	COG0765	amino acid transport
HCN_RS05700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HCN_RS05710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HCN_RS05715	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HCN_RS05725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCN_RS05735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCN_RS05755	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HCN_RS05765	COG1028	Short-chain dehydrogenase reductase Sdr
HCN_RS05790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCN_RS05805	COG1028	Short-chain dehydrogenase reductase Sdr
HCN_RS05820	COG2089	acid synthase
HCN_RS05830	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HCN_RS05845	COG1028	Short-chain dehydrogenase reductase Sdr
HCN_RS05870	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HCN_RS05880	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HCN_RS05890	COG0445	tRNA wobble uridine modification
HCN_RS05900	COG0754	glutathionylspermidine amidase activity
HCN_RS05905	COG2194	sulfuric ester hydrolase activity
HCN_RS05910	COG3118	belongs to the thioredoxin family
HCN_RS05915	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HCN_RS05920	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HCN_RS05925	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HCN_RS05930	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HCN_RS05945	COG0626	cystathionine gamma-synthase activity
HCN_RS05965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCN_RS06055	COG0481	GTPase activity
HCN_RS06065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCN_RS06080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HCN_RS06090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCN_RS06095	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HCN_RS06120	COG1083	cytidylyl-transferase
HCN_RS06125	COG1083	cytidylyl-transferase
HCN_RS06130	COG4221	oxidoreductase activity
HCN_RS06195	COG0772	Belongs to the SEDS family
HCN_RS06210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCN_RS06215	COG0191	fructose-bisphosphate aldolase activity
HCN_RS06220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HCN_RS06245	COG0542	response to heat
HCN_RS06255	COG2204	response regulator
HCN_RS06265	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HCN_RS06275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCN_RS06285	COG0698	ribose 5-phosphate isomerase
HCN_RS06290	COG0681	Belongs to the peptidase S26 family
HCN_RS06295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HCN_RS06305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HCN_RS06310	COG1607	acyl-coa hydrolase
HCN_RS06330	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCN_RS06335	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCN_RS06340	COG1862	Preprotein translocase
HCN_RS06345	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HCN_RS06350	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HCN_RS06365	COG0789	Transcriptional regulator
HCN_RS06370	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HCN_RS06385	COG2204	response regulator
HCN_RS06395	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCN_RS06415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HCN_RS06420	COG1254	Belongs to the acylphosphatase family
HCN_RS06430	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCN_RS06435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HCN_RS06450	COG0539	negative regulation of cytoplasmic translation
HCN_RS06450	COG1185	polyribonucleotide nucleotidyltransferase activity
HCN_RS06455	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HCN_RS06460	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HCN_RS06465	COG1760	l-serine dehydratase
HCN_RS06470	COG0642	Histidine kinase
HCN_RS06475	COG3951	Flagellar rod assembly protein muramidase FlgJ
HCN_RS06480	COG1706	bacterial-type flagellum-dependent cell motility
HCN_RS06505	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCN_RS06560	COG4735	regulation of single-species biofilm formation
HCN_RS06600	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HCN_RS06610	COG0739	heme binding
HCN_RS06635	COG0495	leucyl-tRNA aminoacylation
HCN_RS06700	COG0582	viral genome integration into host DNA
HCN_RS06775	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HCN_RS06785	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HCN_RS07020	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HCN_RS07200	COG3177	Filamentation induced by cAMP protein fic
HCN_RS07405	COG2095	MarC family integral membrane protein
HCN_RS07410	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HCN_RS07415	COG2404	hydrolase activity, acting on ester bonds
HCN_RS07425	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HCN_RS07430	COG0569	domain protein
HCN_RS07430	COG0475	glutathione-regulated potassium exporter activity
HCN_RS07435	COG0733	neurotransmitter:sodium symporter activity
HCN_RS07440	COG4166	transmembrane transport
HCN_RS07445	COG1132	(ABC) transporter
HCN_RS07450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCN_RS07460	COG0138	bifunctional purine biosynthesis protein purh
HCN_RS07475	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HCN_RS07480	COG0492	ferredoxin-NADP+ reductase activity
HCN_RS07485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HCN_RS07490	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HCN_RS07495	COG1242	4 iron, 4 sulfur cluster binding
HCN_RS07500	COG0166	Belongs to the GPI family
HCN_RS07515	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HCN_RS07525	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HCN_RS07530	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HCN_RS07535	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HCN_RS07545	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HCN_RS07550	COG1360	Flagellar Motor Protein
HCN_RS07565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HCN_RS07570	COG0049	tRNA binding
HCN_RS07575	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HCN_RS07580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HCN_RS07580	COG0085	RNA polymerase activity
HCN_RS07585	COG0222	ribosome binding
HCN_RS07590	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HCN_RS07595	COG0081	regulation of translation
HCN_RS07600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HCN_RS07605	COG0250	Participates in transcription elongation, termination and antitermination
HCN_RS07620	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HCN_RS07625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HCN_RS07680	COG0436	Aminotransferase
HCN_RS07695	COG1193	negative regulation of DNA recombination
HCN_RS07710	COG0840	transmembrane signaling receptor activity
HCN_RS07715	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCN_RS07725	COG0439	Biotin carboxylase
HCN_RS07730	COG0511	ligase activity, forming carbon-carbon bonds
HCN_RS07735	COG0717	Belongs to the dCTP deaminase family
HCN_RS07755	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HCN_RS07760	COG1749	Flagellar hook protein flgE
HCN_RS07780	COG1598	PFAM Uncharacterised protein family UPF0150
HCN_RS07815	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HCN_RS07825	COG2079	MmgE PrpD family protein
HCN_RS07830	COG0372	Belongs to the citrate synthase family
HCN_RS07850	COG1741	Belongs to the pirin family
HCN_RS07860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCN_RS07865	COG1854	S-ribosylhomocysteine lyase activity
HCN_RS07875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCN_RS07880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HCN_RS07890	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HCN_RS07895	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HCN_RS07905	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HCN_RS07905	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HCN_RS07910	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HCN_RS07940	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HCN_RS07945	COG1918	ferrous iron import across plasma membrane
HCN_RS07960	COG0039	L-malate dehydrogenase activity
HCN_RS07970	COG0674	pyruvate-flavodoxin oxidoreductase activity
HCN_RS07970	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HCN_RS07975	COG1013	pyruvate-flavodoxin oxidoreductase activity
HCN_RS07985	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HCN_RS07990	COG0542	response to heat
HCN_RS08010	COG4221	oxidoreductase activity
HCN_RS08015	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HCN_RS08025	COG2255	four-way junction helicase activity
HCN_RS08030	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HCN_RS08045	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HCN_RS08060	COG0840	transmembrane signaling receptor activity
HCN_RS08065	COG0632	four-way junction helicase activity
HCN_RS08075	COG0728	peptidoglycan biosynthetic process
HCN_RS08080	COG0215	cysteine-tRNA ligase activity
HCN_RS08085	COG0196	riboflavin kinase activity
HCN_RS08100	COG0540	Belongs to the ATCase OTCase family
HCN_RS08110	COG0575	Belongs to the CDS family
HCN_RS08115	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HCN_RS08120	COG1473	amidohydrolase
HCN_RS08295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCN_RS08300	COG1921	L-seryl-tRNASec selenium transferase activity
HCN_RS08315	COG0303	'Molybdopterin
HCN_RS08320	COG0589	response to stress
HCN_RS08345	COG2194	sulfuric ester hydrolase activity
HCN_RS08350	COG2194	sulfuric ester hydrolase activity
HCN_RS08355	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HCN_RS08375	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HCN_RS08380	COG0849	cell division
HCN_RS08395	COG0564	pseudouridine synthase activity
HCN_RS08405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HCN_RS08410	COG1136	(ABC) transporter
HCN_RS08430	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HCN_RS08445	COG0776	regulation of translation
HCN_RS08450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HCN_RS08460	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HCN_RS08500	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HCN_RS08505	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HCN_RS08510	COG0375	protein maturation
HCN_RS08525	COG1215	transferase activity, transferring glycosyl groups
HCN_RS08560	COG0733	neurotransmitter:sodium symporter activity
HCN_RS08580	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HCN_RS08585	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HCN_RS08600	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HCN_RS08645	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HCN_RS08650	COG0671	phosphoesterase, PA-phosphatase related
HCN_RS08655	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HCN_RS08660	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HCN_RS08665	COG0440	acetolactate synthase activity
HCN_RS08670	COG0028	Belongs to the TPP enzyme family
HCN_RS08675	COG2807	transmembrane transport
HCN_RS08700	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HCN_RS08710	COG0277	FAD linked oxidase domain protein
HCN_RS08725	COG0741	lytic transglycosylase activity
HCN_RS08725	COG1196	nuclear chromosome segregation
HCN_RS08725	COG0739	heme binding
HCN_RS08760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCN_RS08765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCN_RS08775	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HCN_RS08795	COG0824	Thioesterase
HCN_RS08855	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCN_RS08865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCN_RS08875	COG0733	neurotransmitter:sodium symporter activity
HCN_RS08880	COG0505	Belongs to the CarA family
HCN_RS08890	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HCN_RS08900	COG0735	belongs to the Fur family
HCN_RS08920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HCN_RS08925	COG0697	spore germination
HCN_RS08930	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HCN_RS08935	COG1083	cytidylyl-transferase
HCN_RS08950	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HCN_RS08955	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HCN_RS08960	COG2089	acid synthase
HCN_RS08965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCN_RS08970	COG0352	thiamine-phosphate diphosphorylase activity
HCN_RS08975	COG0670	Belongs to the BI1 family
HCN_RS08980	COG0348	domain, Protein
HCN_RS08990	COG0488	(ABC) transporter
HCN_RS09015	COG2195	Cleaves the N-terminal amino acid of tripeptides
HCN_RS09020	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HCN_RS09030	COG0784	Response regulator, receiver
HCN_RS09030	COG0835	chemotaxis
HCN_RS09035	COG0784	Response regulator, receiver
HCN_RS09035	COG0643	Histidine kinase
HCN_RS09035	COG2198	Histidine kinase
HCN_RS09040	COG0835	chemotaxis
HCN_RS09065	COG0560	Phosphoserine phosphatase
HCN_RS09070	COG0662	Cupin 2, conserved barrel domain protein
HCN_RS09070	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HCN_RS09075	COG1793	dna ligase
HCN_RS09080	COG0105	UTP biosynthetic process
HCN_RS09090	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HCN_RS09095	COG0416	fatty acid biosynthetic process
HCN_RS09100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCN_RS09105	COG2217	Heavy metal translocating P-type atpase
HCN_RS09110	COG2608	mercury ion transmembrane transporter activity
HCN_RS09120	COG0343	queuine tRNA-ribosyltransferase activity
HCN_RS09135	COG2217	Heavy metal translocating P-type atpase
HCN_RS09140	COG2608	mercury ion transmembrane transporter activity
HCN_RS09145	COG1132	(ABC) transporter
HCN_RS09155	COG1053	succinate dehydrogenase
HCN_RS09160	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HCN_RS09165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCN_RS09180	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HCN_RS09190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HCN_RS09195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCN_RS09225	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HCN_RS09230	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCN_RS09245	COG0275	rRNA processing
HCN_RS09270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCN_RS09280	COG0243	molybdopterin cofactor binding
HCN_RS09300	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HCN_RS09305	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HCN_RS09310	COG0482	sulfurtransferase activity
HCN_RS09315	COG4771	TonB-dependent receptor
HCN_RS09320	COG1027	Aspartate ammonia-lyase
HCN_RS09325	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HCN_RS09350	COG0194	GDP metabolic process
HCN_RS09360	COG0018	arginyl-trna synthetase
HCN_RS09365	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HCN_RS09370	COG1687	branched-chain amino acid
HCN_RS09375	COG0716	FMN binding
HCN_RS09380	COG4771	TonB-dependent receptor
HCN_RS09410	COG2011	ABC-type metal ion transport system permease component
HCN_RS09415	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCN_RS09420	COG1187	pseudouridine synthase activity
HCN_RS09430	COG2171	N-acyltransferase activity
HCN_RS09445	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HCN_RS09465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCN_RS09480	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HCN_RS09485	COG0497	DNA recombination
HCN_RS09490	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HCN_RS09520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HCN_RS09525	COG0280	phosphate acetyltransferase
HCN_RS09530	COG0840	transmembrane signaling receptor activity
HCN_RS09535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCN_RS09540	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HCN_RS09545	COG0149	triose-phosphate isomerase activity
HCN_RS09555	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HCN_RS09560	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HCN_RS09570	COG3421	Type III restriction
HCN_RS09745	COG0629	single-stranded DNA binding
HCN_RS09750	COG0582	viral genome integration into host DNA
HCN_RS09780	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCN_RS09785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCN_RS09795	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HCN_RS09805	COG0084	hydrolase, TatD family'
HCN_RS09810	COG0739	heme binding
HCN_RS09810	COG0741	lytic transglycosylase activity
HCN_RS09810	COG1196	nuclear chromosome segregation
HCN_RS09815	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HCN_RS09820	COG0131	Imidazoleglycerol-phosphate dehydratase
HCN_RS09825	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HCN_RS09840	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HCN_RS09855	COG0768	penicillin binding
HCN_RS09860	COG1086	Polysaccharide biosynthesis protein
HCN_RS09865	COG1528	Iron-storage protein
HCN_RS09870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HCN_RS09885	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCN_RS09885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCN_RS09940	COG0037	tRNA processing
HCN_RS09950	COG2851	Citrate transporter
HCN_RS09955	COG0748	coenzyme F420 binding
HCN_RS09965	COG1408	metallophosphoesterase
HCN_RS09975	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HCN_RS09980	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HCN_RS09985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HCN_RS10010	COG1194	a g-specific adenine glycosylase
HCN_RS10020	COG0004	ammonium transporteR
HCN_RS10025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCN_RS10040	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HCN_RS10045	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HCN_RS10060	COG1045	serine acetyltransferase
HCN_RS10065	COG1166	arginine decarboxylase activity
HCN_RS10070	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HCN_RS10080	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HCN_RS10095	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HCN_RS10100	COG2894	cell division
HCN_RS10115	COG0137	argininosuccinate synthase activity
HCN_RS10120	COG2076	Multidrug Resistance protein
HCN_RS10205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCN_RS10215	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HCN_RS10220	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HCN_RS10235	COG0459	protein refolding
HCN_RS10240	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HCN_RS10250	COG0358	DNA primase activity
HCN_RS10275	COG2824	Alkylphosphonate utilization operon protein PhnA
HCN_RS10290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HCN_RS10295	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCN_RS10315	COG1077	Cell shape determining protein MreB Mrl
HCN_RS10320	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HCN_RS10330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HCN_RS10335	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HCN_RS10340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HCN_RS10350	COG0107	imidazoleglycerol-phosphate synthase activity
HCN_RS10355	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HCN_RS10360	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HCN_RS10365	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HCN_RS10365	COG0517	IMP dehydrogenase activity
HCN_RS10375	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HCN_RS10400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCN_RS10410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HCN_RS10415	COG0066	3-isopropylmalate dehydratase activity
HCN_RS10420	COG0473	3-isopropylmalate dehydrogenase activity
HCN_RS10450	COG0187	DNA topoisomerase II activity
HCN_RS10455	COG0592	DNA-directed DNA polymerase activity
HCN_RS10460	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HCN_RS10465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCN_RS10495	COG1459	type II secretion system
HCN_RS10525	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HCN_RS10550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)