locus-tag	class	description
D4K20_RS00020	COG0708	Exodeoxyribonuclease III
D4K20_RS00035	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D4K20_RS00075	COG0195	Participates in both transcription termination and antitermination
D4K20_RS00100	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D4K20_RS00105	COG0348	domain, Protein
D4K20_RS00115	COG0786	glutamate:sodium symporter activity
D4K20_RS00125	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D4K20_RS00175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D4K20_RS00185	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D4K20_RS00190	COG0306	phosphate transporter
D4K20_RS00195	COG1253	flavin adenine dinucleotide binding
D4K20_RS00205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D4K20_RS00220	COG1739	Uncharacterized protein family UPF0029
D4K20_RS00225	COG1981	membrane
D4K20_RS00230	COG2226	methyltransferase
D4K20_RS00245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D4K20_RS00265	COG0163	prenyltransferase activity
D4K20_RS00270	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D4K20_RS00275	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D4K20_RS00295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D4K20_RS00295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D4K20_RS00305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D4K20_RS00315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D4K20_RS00320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D4K20_RS00345	COG0587	DNA-directed DNA polymerase activity
D4K20_RS00350	COG1187	pseudouridine synthase activity
D4K20_RS00355	COG3118	belongs to the thioredoxin family
D4K20_RS00390	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D4K20_RS00400	COG0706	membrane insertase activity
D4K20_RS00420	COG0848	biopolymer transport protein
D4K20_RS00425	COG0811	peptide transport
D4K20_RS00435	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D4K20_RS00445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D4K20_RS00485	COG0616	signal peptide processing
D4K20_RS00490	COG0788	formyltetrahydrofolate deformylase activity
D4K20_RS00515	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D4K20_RS00520	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D4K20_RS00520	COG0517	IMP dehydrogenase activity
D4K20_RS00545	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D4K20_RS00555	COG4962	Type ii secretion system protein e
D4K20_RS00560	COG1157	protein secretion by the type III secretion system
D4K20_RS00565	COG1987	bacterial-type flagellum assembly
D4K20_RS00570	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D4K20_RS00585	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D4K20_RS00590	COG0799	negative regulation of ribosome biogenesis
D4K20_RS00595	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D4K20_RS00635	COG1295	ribonuclease BN
D4K20_RS00650	COG3421	Type III restriction
D4K20_RS00655	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D4K20_RS00665	COG0287	Prephenate dehydrogenase
D4K20_RS00670	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D4K20_RS00675	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D4K20_RS00695	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D4K20_RS00700	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D4K20_RS00705	COG1077	Cell shape determining protein MreB Mrl
D4K20_RS00710	COG1792	Involved in formation and maintenance of cell shape
D4K20_RS00725	COG0745	RESPONSE REGULATOR receiver
D4K20_RS00730	COG0642	Histidine kinase
D4K20_RS00735	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D4K20_RS00735	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D4K20_RS00740	COG0305	Participates in initiation and elongation during chromosome replication
D4K20_RS00750	COG0109	protoheme IX farnesyltransferase activity
D4K20_RS00770	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D4K20_RS00775	COG0157	Belongs to the NadC ModD family
D4K20_RS00795	COG0793	Belongs to the peptidase S41A family
D4K20_RS00805	COG0204	Acyl-transferase
D4K20_RS00830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D4K20_RS00835	COG0126	phosphoglycerate kinase activity
D4K20_RS00840	COG0598	Magnesium transport protein CorA
D4K20_RS00845	COG0861	Integral membrane protein TerC family
D4K20_RS00860	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D4K20_RS00865	COG0848	biopolymer transport protein
D4K20_RS00870	COG0811	peptide transport
D4K20_RS00890	COG0482	sulfurtransferase activity
D4K20_RS00900	COG0484	heat shock protein binding
D4K20_RS00905	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D4K20_RS00910	COG1687	branched-chain amino acid
D4K20_RS00915	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D4K20_RS00935	COG0114	fumarate hydratase activity
D4K20_RS00960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D4K20_RS00985	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D4K20_RS01000	COG0255	Belongs to the universal ribosomal protein uL29 family
D4K20_RS01040	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D4K20_RS01055	COG0201	protein transport
D4K20_RS01060	COG0024	Methionine aminopeptidase
D4K20_RS01065	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D4K20_RS01085	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D4K20_RS01090	COG0202	RNA polymerase activity
D4K20_RS01120	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D4K20_RS01125	COG2353	YceI-like domain
D4K20_RS01135	COG0859	PFAM glycosyl transferase family 9
D4K20_RS01150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D4K20_RS01155	COG0512	Glutamine amidotransferase of anthranilate synthase
D4K20_RS01165	COG0135	phosphoribosylanthranilate isomerase activity
D4K20_RS01165	COG0134	indole-3-glycerol-phosphate synthase activity
D4K20_RS01170	COG0133	tryptophan synthase activity
D4K20_RS01195	COG1007	ATP synthesis coupled electron transport
D4K20_RS01205	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D4K20_RS01215	COG0839	Belongs to the complex I subunit 6 family
D4K20_RS01235	COG0544	peptidyl-prolyl cis-trans isomerase activity
D4K20_RS01260	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D4K20_RS01265	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D4K20_RS01285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D4K20_RS01295	COG0180	Tryptophanyl-tRNA synthetase
D4K20_RS01300	COG4166	transmembrane transport
D4K20_RS01305	COG4174	ABC transporter (Permease)
D4K20_RS01315	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D4K20_RS01320	COG0557	exoribonuclease II activity
D4K20_RS01325	COG1466	dna polymerase III delta subunit
D4K20_RS01340	COG0629	single-stranded DNA binding
D4K20_RS01365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D4K20_RS01385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D4K20_RS01390	COG0505	Belongs to the CarA family
D4K20_RS01405	COG0697	spore germination
D4K20_RS01415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D4K20_RS01430	COG0527	aspartate kinase activity
D4K20_RS01440	COG2863	cytochrome
D4K20_RS01445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D4K20_RS01450	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D4K20_RS01470	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D4K20_RS01475	COG1131	(ABC) transporter
D4K20_RS01500	COG0151	Belongs to the GarS family
D4K20_RS01510	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D4K20_RS01545	COG1045	serine acetyltransferase
D4K20_RS01565	COG1132	(ABC) transporter
D4K20_RS01610	COG0250	Participates in transcription elongation, termination and antitermination
D4K20_RS01640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D4K20_RS01640	COG0085	RNA polymerase activity
D4K20_RS01660	COG0667	Aldo Keto reductase
D4K20_RS01665	COG0859	PFAM glycosyl transferase family 9
D4K20_RS01675	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D4K20_RS01705	COG0569	domain protein
D4K20_RS01705	COG0475	glutathione-regulated potassium exporter activity
D4K20_RS01710	COG0037	tRNA processing
D4K20_RS01715	COG2814	Major facilitator Superfamily
D4K20_RS01725	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D4K20_RS01760	COG2252	PERMEase
D4K20_RS01765	COG0738	Major facilitator superfamily
D4K20_RS01780	COG1126	abc transporter atp-binding protein
D4K20_RS01785	COG0765	amino acid transport
D4K20_RS01795	COG1966	Carbon starvation protein
D4K20_RS01815	COG0492	ferredoxin-NADP+ reductase activity
D4K20_RS01830	COG0716	FMN binding
D4K20_RS01840	COG2184	nucleotidyltransferase activity
D4K20_RS01845	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D4K20_RS01870	COG0525	valine-tRNA ligase activity
D4K20_RS01875	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D4K20_RS01890	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D4K20_RS01895	COG0336	Belongs to the RNA methyltransferase TrmD family
D4K20_RS01900	COG0335	large ribosomal subunit rRNA binding
D4K20_RS01940	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D4K20_RS01940	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D4K20_RS01945	COG1192	Involved in chromosome partitioning
D4K20_RS01950	COG1475	DNA binding
D4K20_RS01975	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D4K20_RS01990	COG0811	peptide transport
D4K20_RS01995	COG0848	biopolymer transport protein
D4K20_RS02005	COG0823	Involved in the tonB-independent uptake of proteins
D4K20_RS02010	COG2885	chlorophyll binding
D4K20_RS02020	COG1047	Peptidyl-prolyl cis-trans
D4K20_RS02050	COG0405	Gamma-glutamyltransferase
D4K20_RS02080	COG0556	nucleotide-excision repair
D4K20_RS02090	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D4K20_RS02095	COG1013	pyruvate-flavodoxin oxidoreductase activity
D4K20_RS02100	COG0674	pyruvate-flavodoxin oxidoreductase activity
D4K20_RS02110	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D4K20_RS02135	COG1064	alcohol dehydrogenase
D4K20_RS02145	COG0363	glucosamine-6-phosphate deaminase activity
D4K20_RS02150	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D4K20_RS02155	COG0129	dihydroxy-acid dehydratase activity
D4K20_RS02160	COG0800	Aldolase
D4K20_RS02165	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D4K20_RS02170	COG4221	oxidoreductase activity
D4K20_RS02210	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D4K20_RS02220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D4K20_RS02240	COG0439	Biotin carboxylase
D4K20_RS02245	COG0511	ligase activity, forming carbon-carbon bonds
D4K20_RS02260	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D4K20_RS02280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D4K20_RS02280	COG1333	cytochrome c biogenesis protein
D4K20_RS02290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D4K20_RS02295	COG2890	protein-(glutamine-N5) methyltransferase activity
D4K20_RS02300	COG0501	Belongs to the peptidase M48B family
D4K20_RS02325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D4K20_RS02335	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D4K20_RS02340	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D4K20_RS02345	COG0835	chemotaxis
D4K20_RS02350	COG0643	Histidine kinase
D4K20_RS02350	COG0784	Response regulator, receiver
D4K20_RS02350	COG2198	Histidine kinase
D4K20_RS02355	COG0784	Response regulator, receiver
D4K20_RS02355	COG0835	chemotaxis
D4K20_RS02365	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D4K20_RS02370	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D4K20_RS02375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D4K20_RS02385	COG1185	polyribonucleotide nucleotidyltransferase activity
D4K20_RS02385	COG0539	negative regulation of cytoplasmic translation
D4K20_RS02400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D4K20_RS02400	COG0072	phenylalanine-tRNA ligase activity
D4K20_RS02410	COG0537	adenosine 5'-monophosphoramidase activity
D4K20_RS02415	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D4K20_RS02475	COG0668	transmembrane transport
D4K20_RS02480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D4K20_RS02485	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D4K20_RS02485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D4K20_RS02495	COG0500	methyltransferase
D4K20_RS02510	COG1166	arginine decarboxylase activity
D4K20_RS02610	COG0668	transmembrane transport
D4K20_RS02630	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D4K20_RS02635	COG0849	cell division
D4K20_RS02645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D4K20_RS02650	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D4K20_RS02655	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D4K20_RS02710	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D4K20_RS02720	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D4K20_RS02730	COG1519	Transferase
D4K20_RS02730	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D4K20_RS02735	COG0564	pseudouridine synthase activity
D4K20_RS02740	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D4K20_RS02755	COG1546	Belongs to the CinA family
D4K20_RS02755	COG1058	Belongs to the CinA family
D4K20_RS02765	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D4K20_RS02790	COG1757	Na H antiporter
D4K20_RS02820	COG0251	oxidation-reduction process
D4K20_RS02825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D4K20_RS02830	COG1115	amino acid carrier protein
D4K20_RS02840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D4K20_RS02845	COG0765	amino acid transport
D4K20_RS02860	COG0477	Major facilitator Superfamily
D4K20_RS02875	COG0602	queuosine metabolic process
D4K20_RS02880	COG0720	synthase
D4K20_RS02895	COG0142	geranyltranstransferase activity
D4K20_RS02920	COG1942	4-Oxalocrotonate Tautomerase
D4K20_RS02935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D4K20_RS02940	COG0670	Belongs to the BI1 family
D4K20_RS02945	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D4K20_RS03015	COG1749	Flagellar hook protein flgE
D4K20_RS03015	COG1749	Flagellar hook protein flgE
D4K20_RS03020	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D4K20_RS03030	COG0280	phosphate acetyltransferase
D4K20_RS03035	COG0280	phosphate acetyltransferase
D4K20_RS03055	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D4K20_RS03060	COG0298	carbon dioxide binding
D4K20_RS03065	COG0409	Hydrogenase expression formation protein
D4K20_RS03100	COG3309	Virulence-associated protein D
D4K20_RS03105	COG1607	acyl-coa hydrolase
D4K20_RS03110	COG0300	oxidoreductase activity
D4K20_RS03115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D4K20_RS03120	COG1120	ATPase activity
D4K20_RS03130	COG0215	cysteine-tRNA ligase activity
D4K20_RS03135	COG0728	peptidoglycan biosynthetic process
D4K20_RS03145	COG0632	four-way junction helicase activity
D4K20_RS03160	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D4K20_RS03170	COG0753	catalase activity
D4K20_RS03185	COG2824	Alkylphosphonate utilization operon protein PhnA
D4K20_RS03195	COG2134	cdp-diacylglycerol pyrophosphatase
D4K20_RS03200	COG1749	Flagellar hook protein flgE
D4K20_RS03205	COG0375	protein maturation
D4K20_RS03240	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D4K20_RS03250	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D4K20_RS03255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D4K20_RS03275	COG0488	(ABC) transporter
D4K20_RS03285	COG0671	phosphoesterase, PA-phosphatase related
D4K20_RS03300	COG0732	type I restriction modification DNA specificity domain
D4K20_RS03315	COG0351	phosphomethylpyrimidine kinase
D4K20_RS03320	COG0352	thiamine-phosphate diphosphorylase activity
D4K20_RS03330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D4K20_RS03335	COG1086	Polysaccharide biosynthesis protein
D4K20_RS03360	COG0776	regulation of translation
D4K20_RS03365	COG1160	GTP binding
D4K20_RS03380	COG0237	dephospho-CoA kinase activity
D4K20_RS03390	COG0516	GMP reductase activity
D4K20_RS03390	COG0517	IMP dehydrogenase activity
D4K20_RS03400	COG0724	RNA recognition motif
D4K20_RS03410	COG0492	ferredoxin-NADP+ reductase activity
D4K20_RS03415	COG3118	belongs to the thioredoxin family
D4K20_RS03420	COG0792	nuclease activity
D4K20_RS03425	COG0460	homoserine dehydrogenase
D4K20_RS03445	COG1125	glycine betaine transport
D4K20_RS03445	COG0517	IMP dehydrogenase activity
D4K20_RS03450	COG1732	Glycine betaine
D4K20_RS03480	COG1360	Flagellar Motor Protein
D4K20_RS03485	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D4K20_RS03490	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D4K20_RS03495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D4K20_RS03515	COG1580	Controls the rotational direction of flagella during chemotaxis
D4K20_RS03520	COG0736	holo-[acyl-carrier-protein] synthase activity
D4K20_RS03540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D4K20_RS03540	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D4K20_RS03560	COG0314	molybdopterin synthase activity
D4K20_RS03565	COG0521	Mo-molybdopterin cofactor biosynthetic process
D4K20_RS03590	COG0740	serine-type endopeptidase activity
D4K20_RS03595	COG0242	peptide deformylase activity
D4K20_RS03600	COG0606	chelatase, subunit chli
D4K20_RS03605	COG2217	Heavy metal translocating P-type atpase
D4K20_RS03610	COG0732	type I restriction modification DNA specificity domain
D4K20_RS03625	COG0653	protein targeting
D4K20_RS03660	COG1049	propionate catabolic process, 2-methylcitrate cycle
D4K20_RS03670	COG0528	UMP kinase activity
D4K20_RS03675	COG1758	RNA polymerase activity
D4K20_RS03680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D4K20_RS03685	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D4K20_RS03695	COG0860	N-Acetylmuramoyl-L-alanine amidase
D4K20_RS03705	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D4K20_RS03710	COG0746	molybdenum cofactor guanylyltransferase activity
D4K20_RS03715	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D4K20_RS03735	COG0552	protein localization to endoplasmic reticulum
D4K20_RS03750	COG1418	mRNA catabolic process
D4K20_RS03760	COG2056	Na+-H+ antiporter family
D4K20_RS03810	COG2884	Cell division ATP-binding protein ftsE
D4K20_RS03815	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D4K20_RS03825	COG0564	pseudouridine synthase activity
D4K20_RS03830	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D4K20_RS03840	COG0772	Belongs to the SEDS family
D4K20_RS03850	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D4K20_RS03860	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D4K20_RS03875	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D4K20_RS03880	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D4K20_RS03885	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D4K20_RS03890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D4K20_RS03915	COG0037	tRNA processing
D4K20_RS03920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D4K20_RS03935	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D4K20_RS03940	COG0252	asparaginase activity
D4K20_RS03960	COG1279	arginine transmembrane transporter activity
D4K20_RS03965	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D4K20_RS03975	COG1137	ATPase activity
D4K20_RS03980	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D4K20_RS03995	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
D4K20_RS04015	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D4K20_RS04025	COG2204	response regulator
D4K20_RS04035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D4K20_RS04040	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D4K20_RS04055	COG4647	ligase activity
D4K20_RS04060	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
D4K20_RS04065	COG0145	ligase activity
D4K20_RS04075	COG2031	fatty acid transporter
D4K20_RS04080	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D4K20_RS04085	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D4K20_RS04090	COG0183	Belongs to the thiolase family
D4K20_RS04115	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D4K20_RS04125	COG1338	Plays a role in the flagellum-specific transport system
D4K20_RS04155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D4K20_RS04165	COG0730	response to heat
D4K20_RS04175	COG4974	Belongs to the 'phage' integrase family
D4K20_RS04210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D4K20_RS04220	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D4K20_RS04230	COG0328	RNA-DNA hybrid ribonuclease activity
D4K20_RS04245	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D4K20_RS04255	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D4K20_RS04260	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D4K20_RS04265	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D4K20_RS04270	COG1528	Iron-storage protein
D4K20_RS04275	COG0560	Phosphoserine phosphatase
D4K20_RS04290	COG1027	Aspartate ammonia-lyase
D4K20_RS04330	COG2084	Dehydrogenase
D4K20_RS04340	COG0617	tRNA 3'-terminal CCA addition
D4K20_RS04365	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D4K20_RS04370	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D4K20_RS04375	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
D4K20_RS04380	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D4K20_RS04385	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D4K20_RS04390	COG2249	NAD(P)H dehydrogenase (quinone) activity
D4K20_RS04405	COG2171	N-acyltransferase activity
D4K20_RS04415	COG0436	Aminotransferase
D4K20_RS04430	COG1193	negative regulation of DNA recombination
D4K20_RS04435	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D4K20_RS04455	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D4K20_RS04465	COG3306	glycosyltransferase involved in LPS biosynthesis
D4K20_RS04480	COG0835	chemotaxis
D4K20_RS04480	COG0784	Response regulator, receiver
D4K20_RS04485	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D4K20_RS04510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D4K20_RS04550	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D4K20_RS04570	COG0840	transmembrane signaling receptor activity
D4K20_RS04575	COG0156	8-amino-7-oxononanoate synthase activity
D4K20_RS04580	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D4K20_RS04615	COG1013	pyruvate-flavodoxin oxidoreductase activity
D4K20_RS04620	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D4K20_RS04620	COG0674	pyruvate-flavodoxin oxidoreductase activity
D4K20_RS04640	COG1918	ferrous iron import across plasma membrane
D4K20_RS04645	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D4K20_RS04650	COG1776	CheC inhibitor of MCP methylation
D4K20_RS04650	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D4K20_RS04665	COG0418	dihydroorotase activity
D4K20_RS04690	COG0681	Belongs to the peptidase S26 family
D4K20_RS04695	COG1994	Peptidase M50
D4K20_RS04700	COG0698	ribose 5-phosphate isomerase
D4K20_RS04720	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D4K20_RS04725	COG0012	GTP binding
D4K20_RS04735	COG0628	permease
D4K20_RS04740	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D4K20_RS04765	COG1028	Short-chain dehydrogenase reductase Sdr
D4K20_RS04775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D4K20_RS04800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D4K20_RS04805	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D4K20_RS04815	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D4K20_RS04855	COG3451	type IV secretory pathway VirB4
D4K20_RS05000	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D4K20_RS05020	COG3586	endonuclease activity
D4K20_RS05025	COG0174	glutamine synthetase
D4K20_RS05045	COG0277	FAD linked oxidase domain protein
D4K20_RS05060	COG0739	heme binding
D4K20_RS05060	COG0741	lytic transglycosylase activity
D4K20_RS05060	COG1196	nuclear chromosome segregation
D4K20_RS05075	COG0187	DNA topoisomerase II activity
D4K20_RS05080	COG0592	DNA-directed DNA polymerase activity
D4K20_RS05090	COG0733	neurotransmitter:sodium symporter activity
D4K20_RS05095	COG0733	neurotransmitter:sodium symporter activity
D4K20_RS05100	COG0824	Thioesterase
D4K20_RS05110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D4K20_RS05180	COG1217	gtp-binding protein TYPA
D4K20_RS05205	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D4K20_RS05295	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D4K20_RS05315	COG1028	Short-chain dehydrogenase reductase Sdr
D4K20_RS05325	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D4K20_RS05330	COG0833	amino acid
D4K20_RS05345	COG0745	RESPONSE REGULATOR receiver
D4K20_RS05370	COG0484	heat shock protein binding
D4K20_RS05375	COG0789	Transcriptional regulator
D4K20_RS05380	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D4K20_RS05380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D4K20_RS05385	COG0735	belongs to the Fur family
D4K20_RS05400	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D4K20_RS05400	COG1776	CheC inhibitor of MCP methylation
D4K20_RS05405	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D4K20_RS05420	COG0455	bacterial-type flagellum organization
D4K20_RS05425	COG1419	protein localization to endoplasmic reticulum
D4K20_RS05430	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D4K20_RS05435	COG0006	proline dipeptidase activity
D4K20_RS05450	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D4K20_RS05455	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D4K20_RS05460	COG2404	hydrolase activity, acting on ester bonds
D4K20_RS05465	COG0745	RESPONSE REGULATOR receiver
D4K20_RS05470	COG1408	metallophosphoesterase
D4K20_RS05500	COG0083	homoserine kinase activity
D4K20_RS05550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D4K20_RS05555	COG0805	protein transport
D4K20_RS05565	COG0357	Ribosomal RNA small subunit methyltransferase G
D4K20_RS05590	COG0745	RESPONSE REGULATOR receiver
D4K20_RS05595	COG2264	protein methyltransferase activity
D4K20_RS05600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D4K20_RS05610	COG1183	phosphatidylcholine synthase activity
D4K20_RS05620	COG2608	mercury ion transmembrane transporter activity
D4K20_RS05640	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
D4K20_RS05650	COG1106	Psort location Cytoplasmic, score
D4K20_RS05665	COG1132	(ABC) transporter
D4K20_RS05685	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D4K20_RS05690	COG0196	riboflavin kinase activity
D4K20_RS05695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D4K20_RS05705	COG1674	ftsk spoiiie
D4K20_RS05710	COG0477	Major facilitator Superfamily
D4K20_RS05715	COG4786	Flagellar basal body rod
D4K20_RS05755	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D4K20_RS05760	COG1766	The M ring may be actively involved in energy transduction
D4K20_RS05775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D4K20_RS05775	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D4K20_RS05780	COG0564	pseudouridine synthase activity
D4K20_RS05835	COG2894	cell division
D4K20_RS05860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D4K20_RS05865	COG3980	spore coat polysaccharide biosynthesis protein
D4K20_RS05870	COG3980	spore coat polysaccharide biosynthesis protein
D4K20_RS05875	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D4K20_RS05900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D4K20_RS05910	COG0748	coenzyme F420 binding
D4K20_RS05940	COG0523	cobalamin synthesis protein
D4K20_RS05950	COG0726	polysaccharide deacetylase
D4K20_RS05955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D4K20_RS05990	COG4608	Belongs to the ABC transporter superfamily
D4K20_RS05995	COG0444	Belongs to the ABC transporter superfamily
D4K20_RS06000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D4K20_RS06005	COG0601	transmembrane transport
D4K20_RS06010	COG0747	negative chemotaxis
D4K20_RS06035	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D4K20_RS06050	COG0019	diaminopimelate decarboxylase activity
D4K20_RS06070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D4K20_RS06075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D4K20_RS06105	COG0859	PFAM glycosyl transferase family 9
D4K20_RS06110	COG0248	Ppx GppA phosphatase
D4K20_RS06120	COG0134	indole-3-glycerol-phosphate synthase activity
D4K20_RS06130	COG0727	PFAM Uncharacterised protein family (UPF0153)
D4K20_RS06155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D4K20_RS06165	COG0402	S-adenosylhomocysteine deaminase activity
D4K20_RS06170	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D4K20_RS06175	COG0785	Cytochrome C biogenesis protein
D4K20_RS06180	COG0542	response to heat
D4K20_RS06205	COG1570	exodeoxyribonuclease VII activity
D4K20_RS06210	COG0750	zinc metalloprotease
D4K20_RS06225	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D4K20_RS06245	COG4239	(ABC) transporter, permease
D4K20_RS06250	COG4172	Belongs to the ABC transporter superfamily
D4K20_RS06275	COG3951	Flagellar rod assembly protein muramidase FlgJ
D4K20_RS06280	COG0642	Histidine kinase
D4K20_RS06285	COG0783	Belongs to the Dps family
D4K20_RS06310	COG0442	prolyl-tRNA aminoacylation
D4K20_RS06325	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D4K20_RS06335	COG0754	glutathionylspermidine amidase activity
D4K20_RS06365	COG0659	secondary active sulfate transmembrane transporter activity
D4K20_RS06375	COG0730	response to heat
D4K20_RS06380	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D4K20_RS06380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D4K20_RS06385	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D4K20_RS06400	COG1104	cysteine desulfurase activity
D4K20_RS06410	COG1881	PFAM PEBP family protein
D4K20_RS06435	COG1598	PFAM Uncharacterised protein family UPF0150
D4K20_RS06450	COG0575	Belongs to the CDS family
D4K20_RS06455	COG0471	metal ion transport
D4K20_RS06460	COG0445	tRNA wobble uridine modification
D4K20_RS06470	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D4K20_RS06495	COG0489	protein tyrosine kinase activity
D4K20_RS06545	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D4K20_RS06550	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D4K20_RS06555	COG0149	triose-phosphate isomerase activity
D4K20_RS06565	COG1053	succinate dehydrogenase
D4K20_RS06570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D4K20_RS06575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D4K20_RS06600	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D4K20_RS06605	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D4K20_RS06615	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D4K20_RS06620	COG1136	(ABC) transporter
D4K20_RS06625	COG2089	acid synthase
D4K20_RS06660	COG0191	fructose-bisphosphate aldolase activity
D4K20_RS06665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D4K20_RS06680	COG0303	'Molybdopterin
D4K20_RS06695	COG0826	peptidase U32
D4K20_RS06710	COG0745	RESPONSE REGULATOR receiver
D4K20_RS06715	COG0642	Histidine kinase
D4K20_RS06720	COG0113	porphobilinogen synthase activity
D4K20_RS06725	COG0217	transcriptional regulatory protein
D4K20_RS06735	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D4K20_RS06765	COG0148	phosphopyruvate hydratase activity
D4K20_RS06815	COG3278	Belongs to the heme-copper respiratory oxidase family
D4K20_RS06820	COG0471	metal ion transport
D4K20_RS06825	COG1194	a g-specific adenine glycosylase
D4K20_RS06830	COG1620	l-lactate permease
D4K20_RS06835	COG1620	l-lactate permease
D4K20_RS06840	COG0247	lactate metabolic process
D4K20_RS06845	COG1139	Iron-sulfur cluster binding protein
D4K20_RS06855	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D4K20_RS06865	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D4K20_RS06870	COG0814	amino acid
D4K20_RS06875	COG1760	l-serine dehydratase
D4K20_RS06915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D4K20_RS06925	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D4K20_RS06930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D4K20_RS06940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D4K20_RS06940	COG0574	Belongs to the PEP-utilizing enzyme family
D4K20_RS06950	COG0731	radical SAM domain protein
D4K20_RS06955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D4K20_RS06955	COG0551	DNA topoisomerase type I activity
D4K20_RS06960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D4K20_RS06980	COG1420	regulation of RNA biosynthetic process
D4K20_RS07000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D4K20_RS07005	COG0626	cystathionine gamma-synthase activity
D4K20_RS07015	COG0737	Belongs to the 5'-nucleotidase family
D4K20_RS07025	COG1216	Glycosyl transferase, family 2
D4K20_RS07035	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D4K20_RS07040	COG0840	transmembrane signaling receptor activity
D4K20_RS07045	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D4K20_RS07055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D4K20_RS07090	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D4K20_RS07095	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D4K20_RS07100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D4K20_RS07110	COG0579	oxidoreductase
D4K20_RS07175	COG0832	Belongs to the urease beta subunit family
D4K20_RS07175	COG0831	urea catabolic process
D4K20_RS07195	COG0830	nickel cation binding
D4K20_RS07285	COG4962	Type ii secretion system protein e
D4K20_RS07325	COG3451	type IV secretory pathway VirB4
D4K20_RS07400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D4K20_RS07425	COG1192	Involved in chromosome partitioning
D4K20_RS07485	COG3550	peptidyl-serine autophosphorylation
D4K20_RS07490	COG4974	Belongs to the 'phage' integrase family
D4K20_RS07505	COG0582	viral genome integration into host DNA
D4K20_RS07555	COG0506	proline dehydrogenase activity
D4K20_RS07555	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D4K20_RS07555	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D4K20_RS07560	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D4K20_RS07585	COG1598	PFAM Uncharacterised protein family UPF0150
D4K20_RS07620	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D4K20_RS07645	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D4K20_RS07695	COG0542	response to heat
D4K20_RS07700	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D4K20_RS07705	COG0589	response to stress
D4K20_RS07725	COG0538	isocitrate dehydrogenase activity
D4K20_RS07730	COG0372	Belongs to the citrate synthase family
D4K20_RS07750	COG2194	sulfuric ester hydrolase activity
D4K20_RS07755	COG0671	phosphoesterase, PA-phosphatase related
D4K20_RS07765	COG0835	chemotaxis
D4K20_RS07765	COG0784	Response regulator, receiver
D4K20_RS07800	COG0482	sulfurtransferase activity
D4K20_RS07805	COG0358	DNA primase activity
D4K20_RS07815	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D4K20_RS07860	COG0284	orotidine-5'-phosphate decarboxylase activity
D4K20_RS07865	COG0288	reversible hydration of carbon dioxide
D4K20_RS07870	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D4K20_RS07885	COG4735	regulation of single-species biofilm formation
D4K20_RS07890	COG4786	Flagellar basal body rod
D4K20_RS07910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D4K20_RS07915	COG0671	phosphoesterase, PA-phosphatase related
D4K20_RS07930	COG2011	ABC-type metal ion transport system permease component
D4K20_RS07935	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D4K20_RS07945	COG0307	riboflavin synthase, alpha
D4K20_RS07950	COG0084	hydrolase, TatD family'
D4K20_RS07955	COG1388	LysM domain
D4K20_RS07955	COG0741	lytic transglycosylase activity
D4K20_RS07960	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D4K20_RS07965	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D4K20_RS07990	COG0768	penicillin binding
D4K20_RS08000	COG0450	alkyl hydroperoxide reductase
D4K20_RS08015	COG0772	Belongs to the SEDS family
D4K20_RS08020	COG1815	bacterial-type flagellum-dependent cell motility
D4K20_RS08025	COG1558	bacterial-type flagellum-dependent cell motility
D4K20_RS08040	COG0768	penicillin binding
D4K20_RS08045	COG1106	Psort location Cytoplasmic, score
D4K20_RS08065	COG0723	plastoquinol--plastocyanin reductase activity
D4K20_RS08070	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D4K20_RS08080	COG0739	heme binding
D4K20_RS08090	COG0285	dihydrofolate synthase activity
D4K20_RS08110	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D4K20_RS08115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D4K20_RS08120	COG1862	Preprotein translocase
D4K20_RS08125	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D4K20_RS08130	COG1074	ATP-dependent DNA helicase activity
D4K20_RS08150	COG2176	DNA-directed DNA polymerase activity
D4K20_RS08155	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D4K20_RS08185	COG0497	DNA recombination
D4K20_RS08205	COG0686	Belongs to the AlaDH PNT family
D4K20_RS08210	COG0010	Belongs to the arginase family
D4K20_RS08215	COG4772	TonB-dependent receptor
D4K20_RS08225	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D4K20_RS08245	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D4K20_RS08250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity