locus-tag	class	description
HP2017_RS00015	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HP2017_RS00020	COG0288	reversible hydration of carbon dioxide
HP2017_RS00030	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HP2017_RS00060	COG0459	protein refolding
HP2017_RS00065	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HP2017_RS00070	COG0358	DNA primase activity
HP2017_RS00105	COG0835	chemotaxis
HP2017_RS00105	COG0784	Response regulator, receiver
HP2017_RS00115	COG0671	phosphoesterase, PA-phosphatase related
HP2017_RS00120	COG2194	sulfuric ester hydrolase activity
HP2017_RS00135	COG0372	Belongs to the citrate synthase family
HP2017_RS00140	COG0538	isocitrate dehydrogenase activity
HP2017_RS00150	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HP2017_RS00160	COG0589	response to stress
HP2017_RS00165	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HP2017_RS00170	COG0542	response to heat
HP2017_RS00175	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HP2017_RS00220	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HP2017_RS00245	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HP2017_RS00250	COG2957	Belongs to the agmatine deiminase family
HP2017_RS00275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HP2017_RS00355	COG0830	nickel cation binding
HP2017_RS00360	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HP2017_RS00375	COG0832	Belongs to the urease beta subunit family
HP2017_RS00375	COG0831	urea catabolic process
HP2017_RS00390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HP2017_RS00395	COG0268	Binds directly to 16S ribosomal RNA
HP2017_RS00400	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HP2017_RS00465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HP2017_RS00470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HP2017_RS00475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HP2017_RS00510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HP2017_RS00530	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HP2017_RS00540	COG1216	Glycosyl transferase, family 2
HP2017_RS00550	COG0737	Belongs to the 5'-nucleotidase family
HP2017_RS00555	COG1854	S-ribosylhomocysteine lyase activity
HP2017_RS00560	COG0626	cystathionine gamma-synthase activity
HP2017_RS00565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HP2017_RS00575	COG0443	Heat shock 70 kDa protein
HP2017_RS00580	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HP2017_RS00585	COG1420	regulation of RNA biosynthetic process
HP2017_RS00605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HP2017_RS00610	COG0551	DNA topoisomerase type I activity
HP2017_RS00610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HP2017_RS00615	COG0731	radical SAM domain protein
HP2017_RS00625	COG0574	Belongs to the PEP-utilizing enzyme family
HP2017_RS00625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HP2017_RS00640	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HP2017_RS00670	COG1760	l-serine dehydratase
HP2017_RS00675	COG0814	amino acid
HP2017_RS00680	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HP2017_RS00690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HP2017_RS00700	COG1139	Iron-sulfur cluster binding protein
HP2017_RS00705	COG0247	lactate metabolic process
HP2017_RS00710	COG1620	l-lactate permease
HP2017_RS00715	COG1620	l-lactate permease
HP2017_RS00720	COG1194	a g-specific adenine glycosylase
HP2017_RS00725	COG0471	metal ion transport
HP2017_RS00730	COG3278	Belongs to the heme-copper respiratory oxidase family
HP2017_RS00775	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HP2017_RS00780	COG0148	phosphopyruvate hydratase activity
HP2017_RS00795	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HP2017_RS00810	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HP2017_RS00815	COG0217	transcriptional regulatory protein
HP2017_RS00820	COG0113	porphobilinogen synthase activity
HP2017_RS00825	COG0642	Histidine kinase
HP2017_RS00830	COG0745	RESPONSE REGULATOR receiver
HP2017_RS00845	COG0826	peptidase U32
HP2017_RS00860	COG0303	'Molybdopterin
HP2017_RS00880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HP2017_RS00885	COG0191	fructose-bisphosphate aldolase activity
HP2017_RS00890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HP2017_RS00895	COG2089	acid synthase
HP2017_RS00900	COG1136	(ABC) transporter
HP2017_RS00905	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HP2017_RS00915	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HP2017_RS00950	COG2862	Uncharacterized protein family, UPF0114
HP2017_RS00955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HP2017_RS00960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HP2017_RS00965	COG1053	succinate dehydrogenase
HP2017_RS00975	COG0149	triose-phosphate isomerase activity
HP2017_RS00980	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HP2017_RS00985	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HP2017_RS00990	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HP2017_RS01010	COG0416	fatty acid biosynthetic process
HP2017_RS01015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HP2017_RS01035	COG0489	protein tyrosine kinase activity
HP2017_RS01055	COG0326	Molecular chaperone. Has ATPase activity
HP2017_RS01060	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HP2017_RS01065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HP2017_RS01070	COG0445	tRNA wobble uridine modification
HP2017_RS01075	COG0471	metal ion transport
HP2017_RS01080	COG0575	Belongs to the CDS family
HP2017_RS01085	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HP2017_RS01100	COG1881	PFAM PEBP family protein
HP2017_RS01110	COG1104	cysteine desulfurase activity
HP2017_RS01125	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HP2017_RS01130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HP2017_RS01130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HP2017_RS01135	COG0730	response to heat
HP2017_RS01145	COG0659	secondary active sulfate transmembrane transporter activity
HP2017_RS01160	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HP2017_RS01175	COG0754	glutathionylspermidine amidase activity
HP2017_RS01185	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HP2017_RS01195	COG0181	hydroxymethylbilane synthase activity
HP2017_RS01205	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HP2017_RS01225	COG0783	Belongs to the Dps family
HP2017_RS01230	COG0642	Histidine kinase
HP2017_RS01235	COG3951	Flagellar rod assembly protein muramidase FlgJ
HP2017_RS01245	COG0513	Belongs to the DEAD box helicase family
HP2017_RS01260	COG4172	Belongs to the ABC transporter superfamily
HP2017_RS01265	COG4239	(ABC) transporter, permease
HP2017_RS01285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HP2017_RS01300	COG0750	zinc metalloprotease
HP2017_RS01305	COG1570	exodeoxyribonuclease VII activity
HP2017_RS01335	COG0542	response to heat
HP2017_RS01340	COG0785	Cytochrome C biogenesis protein
HP2017_RS01345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HP2017_RS01350	COG0402	S-adenosylhomocysteine deaminase activity
HP2017_RS01385	COG0727	PFAM Uncharacterised protein family (UPF0153)
HP2017_RS01395	COG0134	indole-3-glycerol-phosphate synthase activity
HP2017_RS01405	COG0248	Ppx GppA phosphatase
HP2017_RS01410	COG0859	PFAM glycosyl transferase family 9
HP2017_RS01420	COG0343	queuine tRNA-ribosyltransferase activity
HP2017_RS01430	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HP2017_RS01440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HP2017_RS01445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HP2017_RS01465	COG0019	diaminopimelate decarboxylase activity
HP2017_RS01480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HP2017_RS01500	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HP2017_RS01505	COG0747	negative chemotaxis
HP2017_RS01510	COG0601	transmembrane transport
HP2017_RS01515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HP2017_RS01520	COG0444	Belongs to the ABC transporter superfamily
HP2017_RS01525	COG4608	Belongs to the ABC transporter superfamily
HP2017_RS01530	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HP2017_RS01545	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HP2017_RS01560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HP2017_RS01575	COG0523	cobalamin synthesis protein
HP2017_RS01590	COG1131	(ABC) transporter
HP2017_RS01595	COG0748	coenzyme F420 binding
HP2017_RS01600	COG0018	arginyl-trna synthetase
HP2017_RS01605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HP2017_RS01610	COG0194	GDP metabolic process
HP2017_RS01630	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HP2017_RS01635	COG3980	spore coat polysaccharide biosynthesis protein
HP2017_RS01640	COG3980	spore coat polysaccharide biosynthesis protein
HP2017_RS01645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HP2017_RS01650	COG1663	tetraacyldisaccharide 4'-kinase activity
HP2017_RS01670	COG2894	cell division
HP2017_RS01685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HP2017_RS01705	COG0564	pseudouridine synthase activity
HP2017_RS01710	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HP2017_RS01710	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HP2017_RS01715	COG0504	CTP synthase activity
HP2017_RS01725	COG1766	The M ring may be actively involved in energy transduction
HP2017_RS01730	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HP2017_RS01740	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HP2017_RS01760	COG4786	Flagellar basal body rod
HP2017_RS01765	COG0477	Major facilitator Superfamily
HP2017_RS01770	COG1674	ftsk spoiiie
HP2017_RS01780	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HP2017_RS01785	COG0196	riboflavin kinase activity
HP2017_RS01790	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HP2017_RS01800	COG0540	Belongs to the ATCase OTCase family
HP2017_RS01810	COG1132	(ABC) transporter
HP2017_RS01835	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HP2017_RS01855	COG2608	mercury ion transmembrane transporter activity
HP2017_RS01865	COG1183	phosphatidylcholine synthase activity
HP2017_RS01875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HP2017_RS01880	COG2264	protein methyltransferase activity
HP2017_RS01885	COG0745	RESPONSE REGULATOR receiver
HP2017_RS01910	COG0357	Ribosomal RNA small subunit methyltransferase G
HP2017_RS01915	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HP2017_RS01920	COG0805	protein transport
HP2017_RS01925	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HP2017_RS01960	COG0850	regulation of cytokinetic process
HP2017_RS01965	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HP2017_RS01975	COG0083	homoserine kinase activity
HP2017_RS01985	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HP2017_RS02000	COG1408	metallophosphoesterase
HP2017_RS02005	COG0745	RESPONSE REGULATOR receiver
HP2017_RS02010	COG2404	hydrolase activity, acting on ester bonds
HP2017_RS02015	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HP2017_RS02035	COG0006	proline dipeptidase activity
HP2017_RS02040	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HP2017_RS02045	COG1419	protein localization to endoplasmic reticulum
HP2017_RS02050	COG0455	bacterial-type flagellum organization
HP2017_RS02065	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HP2017_RS02070	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HP2017_RS02070	COG1776	CheC inhibitor of MCP methylation
HP2017_RS02085	COG0735	belongs to the Fur family
HP2017_RS02090	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HP2017_RS02090	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HP2017_RS02095	COG0789	Transcriptional regulator
HP2017_RS02100	COG0484	heat shock protein binding
HP2017_RS02115	COG0745	RESPONSE REGULATOR receiver
HP2017_RS02120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HP2017_RS02120	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HP2017_RS02130	COG0833	amino acid
HP2017_RS02135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HP2017_RS02145	COG1028	Short-chain dehydrogenase reductase Sdr
HP2017_RS02150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HP2017_RS02160	COG0167	dihydroorotate dehydrogenase activity
HP2017_RS02165	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HP2017_RS02245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HP2017_RS02260	COG1217	gtp-binding protein TYPA
HP2017_RS02325	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HP2017_RS02335	COG0824	Thioesterase
HP2017_RS02340	COG0733	neurotransmitter:sodium symporter activity
HP2017_RS02345	COG0733	neurotransmitter:sodium symporter activity
HP2017_RS02355	COG0592	DNA-directed DNA polymerase activity
HP2017_RS02360	COG0187	DNA topoisomerase II activity
HP2017_RS02375	COG0741	lytic transglycosylase activity
HP2017_RS02375	COG1196	nuclear chromosome segregation
HP2017_RS02375	COG0739	heme binding
HP2017_RS02390	COG0277	FAD linked oxidase domain protein
HP2017_RS02405	COG0174	glutamine synthetase
HP2017_RS02415	COG0359	binds to the 23S rRNA
HP2017_RS02420	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HP2017_RS02425	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HP2017_RS02430	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HP2017_RS02565	COG3451	type IV secretory pathway VirB4
HP2017_RS02600	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HP2017_RS02610	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HP2017_RS02615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HP2017_RS02640	COG0825	malonyl-CoA metabolic process
HP2017_RS02645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HP2017_RS02650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HP2017_RS02655	COG1028	Short-chain dehydrogenase reductase Sdr
HP2017_RS02680	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HP2017_RS02685	COG0628	permease
HP2017_RS02695	COG0012	GTP binding
HP2017_RS02720	COG0698	ribose 5-phosphate isomerase
HP2017_RS02725	COG1994	Peptidase M50
HP2017_RS02730	COG0681	Belongs to the peptidase S26 family
HP2017_RS02735	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HP2017_RS02755	COG0418	dihydroorotase activity
HP2017_RS02770	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HP2017_RS02770	COG1776	CheC inhibitor of MCP methylation
HP2017_RS02775	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HP2017_RS02780	COG1918	ferrous iron import across plasma membrane
HP2017_RS02800	COG0674	pyruvate-flavodoxin oxidoreductase activity
HP2017_RS02800	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HP2017_RS02805	COG1013	pyruvate-flavodoxin oxidoreductase activity
HP2017_RS02835	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HP2017_RS02840	COG0156	8-amino-7-oxononanoate synthase activity
HP2017_RS02845	COG0840	transmembrane signaling receptor activity
HP2017_RS02855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HP2017_RS02905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HP2017_RS02910	COG0784	Response regulator, receiver
HP2017_RS02910	COG0835	chemotaxis
HP2017_RS02915	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HP2017_RS02925	COG3306	glycosyltransferase involved in LPS biosynthesis
HP2017_RS02935	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HP2017_RS02940	COG1193	negative regulation of DNA recombination
HP2017_RS02950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HP2017_RS02955	COG0436	Aminotransferase
HP2017_RS02965	COG2171	N-acyltransferase activity
HP2017_RS02980	COG2249	NAD(P)H dehydrogenase (quinone) activity
HP2017_RS02985	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HP2017_RS02990	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HP2017_RS02995	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HP2017_RS03000	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HP2017_RS03005	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HP2017_RS03025	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HP2017_RS03030	COG0617	tRNA 3'-terminal CCA addition
HP2017_RS03040	COG2084	Dehydrogenase
HP2017_RS03045	COG0778	Nitroreductase
HP2017_RS03060	COG0762	integral membrane protein
HP2017_RS03085	COG1027	Aspartate ammonia-lyase
HP2017_RS03100	COG0560	Phosphoserine phosphatase
HP2017_RS03105	COG1528	Iron-storage protein
HP2017_RS03110	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HP2017_RS03115	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HP2017_RS03120	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HP2017_RS03130	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HP2017_RS03145	COG0328	RNA-DNA hybrid ribonuclease activity
HP2017_RS03150	COG0571	ribonuclease III activity
HP2017_RS03165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HP2017_RS03205	COG4974	Belongs to the 'phage' integrase family
HP2017_RS03215	COG0730	response to heat
HP2017_RS03225	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HP2017_RS03240	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HP2017_RS03245	COG1338	Plays a role in the flagellum-specific transport system
HP2017_RS03255	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HP2017_RS03275	COG4647	ligase activity
HP2017_RS03295	COG2031	fatty acid transporter
HP2017_RS03300	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HP2017_RS03305	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HP2017_RS03310	COG0183	Belongs to the thiolase family
HP2017_RS03320	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HP2017_RS03325	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HP2017_RS03335	COG2204	response regulator
HP2017_RS03340	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HP2017_RS03350	COG0275	rRNA processing
HP2017_RS03360	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HP2017_RS03370	COG3177	Filamentation induced by cAMP protein fic
HP2017_RS03375	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HP2017_RS03380	COG1137	ATPase activity
HP2017_RS03390	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HP2017_RS03395	COG1279	arginine transmembrane transporter activity
HP2017_RS03420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HP2017_RS03425	COG0037	tRNA processing
HP2017_RS03460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HP2017_RS03465	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HP2017_RS03470	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HP2017_RS03475	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HP2017_RS03480	COG1181	Belongs to the D-alanine--D-alanine ligase family
HP2017_RS03490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HP2017_RS03500	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HP2017_RS03515	COG1136	(ABC) transporter
HP2017_RS03520	COG0564	pseudouridine synthase activity
HP2017_RS03530	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HP2017_RS03535	COG2884	Cell division ATP-binding protein ftsE
HP2017_RS03555	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HP2017_RS03585	COG2056	Na+-H+ antiporter family
HP2017_RS03590	COG0534	Mate efflux family protein
HP2017_RS03610	COG0552	protein localization to endoplasmic reticulum
HP2017_RS03635	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HP2017_RS03640	COG0746	molybdenum cofactor guanylyltransferase activity
HP2017_RS03645	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HP2017_RS03655	COG0860	N-Acetylmuramoyl-L-alanine amidase
HP2017_RS03665	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HP2017_RS03675	COG1758	RNA polymerase activity
HP2017_RS03680	COG0528	UMP kinase activity
HP2017_RS03690	COG1049	propionate catabolic process, 2-methylcitrate cycle
HP2017_RS03720	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HP2017_RS03725	COG0653	protein targeting
HP2017_RS03745	COG2217	Heavy metal translocating P-type atpase
HP2017_RS03750	COG0606	chelatase, subunit chli
HP2017_RS03755	COG0242	peptide deformylase activity
HP2017_RS03760	COG0740	serine-type endopeptidase activity
HP2017_RS03765	COG0544	peptidyl-prolyl cis-trans isomerase activity
HP2017_RS03780	COG0315	cyclic pyranopterin monophosphate synthase activity
HP2017_RS03785	COG0521	Mo-molybdopterin cofactor biosynthetic process
HP2017_RS03790	COG0314	molybdopterin synthase activity
HP2017_RS03800	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HP2017_RS03810	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HP2017_RS03810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HP2017_RS03835	COG1580	Controls the rotational direction of flagella during chemotaxis
HP2017_RS03855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HP2017_RS03860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HP2017_RS03865	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HP2017_RS03870	COG1360	Flagellar Motor Protein
HP2017_RS03880	COG1732	Glycine betaine
HP2017_RS03885	COG0517	IMP dehydrogenase activity
HP2017_RS03885	COG1125	glycine betaine transport
HP2017_RS03900	COG0322	excinuclease ABC activity
HP2017_RS03905	COG0460	homoserine dehydrogenase
HP2017_RS03910	COG0792	nuclease activity
HP2017_RS03915	COG3118	belongs to the thioredoxin family
HP2017_RS03920	COG0492	ferredoxin-NADP+ reductase activity
HP2017_RS03930	COG0724	RNA recognition motif
HP2017_RS03940	COG0516	GMP reductase activity
HP2017_RS03940	COG0517	IMP dehydrogenase activity
HP2017_RS03950	COG0237	dephospho-CoA kinase activity
HP2017_RS03955	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HP2017_RS03965	COG1160	GTP binding
HP2017_RS03970	COG0776	regulation of translation
HP2017_RS03995	COG1086	Polysaccharide biosynthesis protein
HP2017_RS04000	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HP2017_RS04010	COG0352	thiamine-phosphate diphosphorylase activity
HP2017_RS04015	COG0351	phosphomethylpyrimidine kinase
HP2017_RS04020	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HP2017_RS04045	COG0671	phosphoesterase, PA-phosphatase related
HP2017_RS04055	COG0488	(ABC) transporter
HP2017_RS04060	COG0516	GMP reductase activity
HP2017_RS04065	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HP2017_RS04070	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HP2017_RS04070	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HP2017_RS04075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HP2017_RS04080	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HP2017_RS04090	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HP2017_RS04105	COG0756	dUTP diphosphatase activity
HP2017_RS04110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HP2017_RS04125	COG0375	protein maturation
HP2017_RS04130	COG1749	Flagellar hook protein flgE
HP2017_RS04135	COG2134	cdp-diacylglycerol pyrophosphatase
HP2017_RS04140	COG2824	Alkylphosphonate utilization operon protein PhnA
HP2017_RS04155	COG0753	catalase activity
HP2017_RS04180	COG0632	four-way junction helicase activity
HP2017_RS04190	COG0728	peptidoglycan biosynthetic process
HP2017_RS04210	COG1120	ATPase activity
HP2017_RS04215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HP2017_RS04220	COG0300	oxidoreductase activity
HP2017_RS04225	COG1607	acyl-coa hydrolase
HP2017_RS04275	COG0409	Hydrogenase expression formation protein
HP2017_RS04280	COG0298	carbon dioxide binding
HP2017_RS04285	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HP2017_RS04300	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HP2017_RS04305	COG0280	phosphate acetyltransferase
HP2017_RS04315	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HP2017_RS04320	COG1749	Flagellar hook protein flgE
HP2017_RS04320	COG1749	Flagellar hook protein flgE
HP2017_RS04365	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HP2017_RS04370	COG0670	Belongs to the BI1 family
HP2017_RS04375	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HP2017_RS04390	COG1942	4-Oxalocrotonate Tautomerase
HP2017_RS04400	COG0585	pseudouridine synthase activity
HP2017_RS04405	COG0501	Belongs to the peptidase M48B family
HP2017_RS04430	COG0720	synthase
HP2017_RS04435	COG0602	queuosine metabolic process
HP2017_RS04445	COG0477	Major facilitator Superfamily
HP2017_RS04455	COG0765	amino acid transport
HP2017_RS04460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HP2017_RS04465	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HP2017_RS04470	COG1115	amino acid carrier protein
HP2017_RS04475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HP2017_RS04480	COG0251	oxidation-reduction process
HP2017_RS04505	COG1757	Na H antiporter
HP2017_RS04520	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HP2017_RS04525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HP2017_RS04535	COG1058	Belongs to the CinA family
HP2017_RS04535	COG1546	Belongs to the CinA family
HP2017_RS04550	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HP2017_RS04555	COG0564	pseudouridine synthase activity
HP2017_RS04560	COG1519	Transferase
HP2017_RS04570	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HP2017_RS04575	COG0752	glycyl-tRNA synthetase alpha subunit
HP2017_RS04580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HP2017_RS04605	COG0751	glycine-tRNA ligase activity
HP2017_RS04615	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HP2017_RS04620	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HP2017_RS04625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HP2017_RS04635	COG0849	cell division
HP2017_RS04640	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HP2017_RS04655	COG0668	transmembrane transport
HP2017_RS04780	COG1598	PFAM Uncharacterised protein family UPF0150
HP2017_RS04790	COG1166	arginine decarboxylase activity
HP2017_RS04805	COG0500	methyltransferase
HP2017_RS04815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HP2017_RS04815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HP2017_RS04820	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HP2017_RS04825	COG0668	transmembrane transport
HP2017_RS04860	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HP2017_RS04860	COG0519	Catalyzes the synthesis of GMP from XMP
HP2017_RS04880	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HP2017_RS04885	COG0537	adenosine 5'-monophosphoramidase activity
HP2017_RS04895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HP2017_RS04895	COG0072	phenylalanine-tRNA ligase activity
HP2017_RS04900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HP2017_RS04910	COG0539	negative regulation of cytoplasmic translation
HP2017_RS04910	COG1185	polyribonucleotide nucleotidyltransferase activity
HP2017_RS04920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HP2017_RS04925	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HP2017_RS04930	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HP2017_RS04940	COG0835	chemotaxis
HP2017_RS04940	COG0784	Response regulator, receiver
HP2017_RS04945	COG0784	Response regulator, receiver
HP2017_RS04945	COG0643	Histidine kinase
HP2017_RS04945	COG2198	Histidine kinase
HP2017_RS04950	COG0835	chemotaxis
HP2017_RS04955	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HP2017_RS04960	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HP2017_RS04965	COG2226	methyltransferase
HP2017_RS04970	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HP2017_RS04995	COG0501	Belongs to the peptidase M48B family
HP2017_RS05000	COG2890	protein-(glutamine-N5) methyltransferase activity
HP2017_RS05005	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HP2017_RS05015	COG1333	cytochrome c biogenesis protein
HP2017_RS05015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HP2017_RS05025	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HP2017_RS05035	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HP2017_RS05050	COG0511	ligase activity, forming carbon-carbon bonds
HP2017_RS05055	COG0439	Biotin carboxylase
HP2017_RS05075	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HP2017_RS05085	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HP2017_RS05090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HP2017_RS05100	COG0101	tRNA pseudouridine synthase activity
HP2017_RS05130	COG4221	oxidoreductase activity
HP2017_RS05135	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HP2017_RS05140	COG0800	Aldolase
HP2017_RS05145	COG0129	dihydroxy-acid dehydratase activity
HP2017_RS05150	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HP2017_RS05155	COG0363	glucosamine-6-phosphate deaminase activity
HP2017_RS05160	COG0837	glucose binding
HP2017_RS05165	COG1064	alcohol dehydrogenase
HP2017_RS05195	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HP2017_RS05205	COG0674	pyruvate-flavodoxin oxidoreductase activity
HP2017_RS05210	COG1013	pyruvate-flavodoxin oxidoreductase activity
HP2017_RS05215	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HP2017_RS05225	COG0556	nucleotide-excision repair
HP2017_RS05245	COG0405	Gamma-glutamyltransferase
HP2017_RS05275	COG1047	Peptidyl-prolyl cis-trans
HP2017_RS05285	COG2885	chlorophyll binding
HP2017_RS05290	COG0823	Involved in the tonB-independent uptake of proteins
HP2017_RS05300	COG0848	biopolymer transport protein
HP2017_RS05305	COG0811	peptide transport
HP2017_RS05335	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HP2017_RS05345	COG1475	DNA binding
HP2017_RS05350	COG1192	Involved in chromosome partitioning
HP2017_RS05355	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HP2017_RS05355	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HP2017_RS05390	COG0335	large ribosomal subunit rRNA binding
HP2017_RS05395	COG0336	Belongs to the RNA methyltransferase TrmD family
HP2017_RS05410	COG0228	four-way junction DNA binding
HP2017_RS05420	COG0525	valine-tRNA ligase activity
HP2017_RS05445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HP2017_RS05455	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HP2017_RS05460	COG0716	FMN binding
HP2017_RS05475	COG0492	ferredoxin-NADP+ reductase activity
HP2017_RS05485	COG0166	Belongs to the GPI family
HP2017_RS05495	COG1966	Carbon starvation protein
HP2017_RS05505	COG0765	amino acid transport
HP2017_RS05510	COG1126	abc transporter atp-binding protein
HP2017_RS05525	COG0738	Major facilitator superfamily
HP2017_RS05530	COG2252	PERMEase
HP2017_RS05545	COG0813	purine-nucleoside phosphorylase activity
HP2017_RS05550	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HP2017_RS05555	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HP2017_RS05565	COG2814	Major facilitator Superfamily
HP2017_RS05570	COG0037	tRNA processing
HP2017_RS05575	COG0569	domain protein
HP2017_RS05575	COG0475	glutathione-regulated potassium exporter activity
HP2017_RS05600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HP2017_RS05605	COG0124	histidyl-tRNA synthetase
HP2017_RS05620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HP2017_RS05635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HP2017_RS05635	COG0085	RNA polymerase activity
HP2017_RS05650	COG0081	regulation of translation
HP2017_RS05660	COG0250	Participates in transcription elongation, termination and antitermination
HP2017_RS05705	COG1132	(ABC) transporter
HP2017_RS05725	COG1045	serine acetyltransferase
HP2017_RS05745	COG1185	polyribonucleotide nucleotidyltransferase activity
HP2017_RS05755	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HP2017_RS05770	COG1131	(ABC) transporter
HP2017_RS05775	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HP2017_RS05795	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HP2017_RS05800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HP2017_RS05805	COG2863	cytochrome
HP2017_RS05815	COG0527	aspartate kinase activity
HP2017_RS05855	COG0505	Belongs to the CarA family
HP2017_RS05875	COG0424	maF-like protein
HP2017_RS05880	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HP2017_RS05900	COG0629	single-stranded DNA binding
HP2017_RS05905	COG0360	Binds together with S18 to 16S ribosomal RNA
HP2017_RS05910	COG1466	dna polymerase III delta subunit
HP2017_RS05915	COG0557	exoribonuclease II activity
HP2017_RS05930	COG4174	ABC transporter (Permease)
HP2017_RS05935	COG4166	transmembrane transport
HP2017_RS05940	COG0180	Tryptophanyl-tRNA synthetase
HP2017_RS05950	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HP2017_RS05970	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HP2017_RS05975	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HP2017_RS05985	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HP2017_RS06010	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HP2017_RS06015	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HP2017_RS06020	COG0839	Belongs to the complex I subunit 6 family
HP2017_RS06030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HP2017_RS06040	COG1007	ATP synthesis coupled electron transport
HP2017_RS06065	COG0159	tryptophan synthase activity
HP2017_RS06070	COG0133	tryptophan synthase activity
HP2017_RS06075	COG0134	indole-3-glycerol-phosphate synthase activity
HP2017_RS06075	COG0135	phosphoribosylanthranilate isomerase activity
HP2017_RS06080	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HP2017_RS06085	COG0512	Glutamine amidotransferase of anthranilate synthase
HP2017_RS06090	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HP2017_RS06095	COG0859	PFAM glycosyl transferase family 9
HP2017_RS06105	COG2353	YceI-like domain
HP2017_RS06110	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HP2017_RS06140	COG0202	RNA polymerase activity
HP2017_RS06145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HP2017_RS06155	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HP2017_RS06165	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HP2017_RS06170	COG0024	Methionine aminopeptidase
HP2017_RS06175	COG0201	protein transport
HP2017_RS06180	COG0200	Binds to the 23S rRNA
HP2017_RS06195	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HP2017_RS06215	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HP2017_RS06230	COG0255	Belongs to the universal ribosomal protein uL29 family
HP2017_RS06245	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HP2017_RS06265	COG0088	Forms part of the polypeptide exit tunnel
HP2017_RS06270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HP2017_RS06300	COG0114	fumarate hydratase activity
HP2017_RS06315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HP2017_RS06320	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HP2017_RS06325	COG1687	branched-chain amino acid
HP2017_RS06330	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HP2017_RS06335	COG0484	heat shock protein binding
HP2017_RS06350	COG0482	sulfurtransferase activity
HP2017_RS06360	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HP2017_RS06370	COG0811	peptide transport
HP2017_RS06375	COG0848	biopolymer transport protein
HP2017_RS06395	COG0861	Integral membrane protein TerC family
HP2017_RS06400	COG0598	Magnesium transport protein CorA
HP2017_RS06405	COG0126	phosphoglycerate kinase activity
HP2017_RS06410	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HP2017_RS06415	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HP2017_RS06420	COG0204	Acyl-transferase
HP2017_RS06430	COG0793	Belongs to the peptidase S41A family
HP2017_RS06455	COG0157	Belongs to the NadC ModD family
HP2017_RS06460	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HP2017_RS06480	COG0109	protoheme IX farnesyltransferase activity
HP2017_RS06490	COG0305	Participates in initiation and elongation during chromosome replication
HP2017_RS06495	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HP2017_RS06495	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HP2017_RS06500	COG0642	Histidine kinase
HP2017_RS06505	COG0745	RESPONSE REGULATOR receiver
HP2017_RS06520	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HP2017_RS06535	COG1792	Involved in formation and maintenance of cell shape
HP2017_RS06540	COG1077	Cell shape determining protein MreB Mrl
HP2017_RS06545	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HP2017_RS06550	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HP2017_RS06555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HP2017_RS06560	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HP2017_RS06570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HP2017_RS06575	COG0287	Prephenate dehydrogenase
HP2017_RS06595	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HP2017_RS06610	COG1295	ribonuclease BN
HP2017_RS06635	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HP2017_RS06640	COG0799	negative regulation of ribosome biogenesis
HP2017_RS06645	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HP2017_RS06665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HP2017_RS06670	COG1987	bacterial-type flagellum assembly
HP2017_RS06675	COG1157	protein secretion by the type III secretion system
HP2017_RS06680	COG4962	Type ii secretion system protein e
HP2017_RS06685	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HP2017_RS06690	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HP2017_RS06715	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HP2017_RS06720	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HP2017_RS06725	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HP2017_RS06725	COG0517	IMP dehydrogenase activity
HP2017_RS06730	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HP2017_RS06740	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HP2017_RS06745	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HP2017_RS06750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HP2017_RS06755	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HP2017_RS06760	COG0811	peptide transport
HP2017_RS06765	COG0848	biopolymer transport protein
HP2017_RS06775	COG0594	ribonuclease P activity
HP2017_RS06780	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HP2017_RS06785	COG0706	membrane insertase activity
HP2017_RS06795	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HP2017_RS06825	COG3118	belongs to the thioredoxin family
HP2017_RS06830	COG1187	pseudouridine synthase activity
HP2017_RS06835	COG0587	DNA-directed DNA polymerase activity
HP2017_RS06860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HP2017_RS06865	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HP2017_RS06875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HP2017_RS06885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HP2017_RS06885	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HP2017_RS06920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HP2017_RS06925	COG0163	prenyltransferase activity
HP2017_RS06935	COG0210	DNA helicase
HP2017_RS06945	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HP2017_RS06955	COG1722	exodeoxyribonuclease VII activity
HP2017_RS06960	COG2226	methyltransferase
HP2017_RS06965	COG1981	membrane
HP2017_RS06970	COG1739	Uncharacterized protein family UPF0029
HP2017_RS06985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HP2017_RS06995	COG1253	flavin adenine dinucleotide binding
HP2017_RS07005	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HP2017_RS07015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HP2017_RS07065	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HP2017_RS07075	COG0786	glutamate:sodium symporter activity
HP2017_RS07085	COG0348	domain, Protein
HP2017_RS07090	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HP2017_RS07110	COG1921	L-seryl-tRNASec selenium transferase activity
HP2017_RS07115	COG0195	Participates in both transcription termination and antitermination
HP2017_RS07130	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HP2017_RS07145	COG0708	Exodeoxyribonuclease III
HP2017_RS07165	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HP2017_RS07180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HP2017_RS07185	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HP2017_RS07200	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HP2017_RS07220	COG0686	Belongs to the AlaDH PNT family
HP2017_RS07225	COG1064	alcohol dehydrogenase
HP2017_RS07240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HP2017_RS07245	COG0497	DNA recombination
HP2017_RS07280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HP2017_RS07305	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HP2017_RS07315	COG1074	ATP-dependent DNA helicase activity
HP2017_RS07320	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HP2017_RS07325	COG1862	Preprotein translocase
HP2017_RS07330	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HP2017_RS07335	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HP2017_RS07345	COG0495	leucyl-tRNA aminoacylation
HP2017_RS07365	COG0739	heme binding
HP2017_RS07375	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HP2017_RS07380	COG0723	plastoquinol--plastocyanin reductase activity
HP2017_RS07405	COG0768	penicillin binding
HP2017_RS07415	COG1558	bacterial-type flagellum-dependent cell motility
HP2017_RS07420	COG1815	bacterial-type flagellum-dependent cell motility
HP2017_RS07425	COG0772	Belongs to the SEDS family
HP2017_RS07440	COG0450	alkyl hydroperoxide reductase
HP2017_RS07450	COG0768	penicillin binding
HP2017_RS07475	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HP2017_RS07480	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HP2017_RS07485	COG0741	lytic transglycosylase activity
HP2017_RS07485	COG1388	LysM domain
HP2017_RS07490	COG0084	hydrolase, TatD family'
HP2017_RS07495	COG0307	riboflavin synthase, alpha
HP2017_RS07505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HP2017_RS07510	COG2011	ABC-type metal ion transport system permease component
HP2017_RS07520	COG0671	phosphoesterase, PA-phosphatase related
HP2017_RS07525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HP2017_RS07540	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HP2017_RS07545	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HP2017_RS07550	COG4786	Flagellar basal body rod
HP2017_RS07555	COG4735	regulation of single-species biofilm formation
HP2017_RS07595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HP2017_RS07595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation