locus-tag	class	description
D4K63_RS00020	COG0708	Exodeoxyribonuclease III
D4K63_RS00035	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D4K63_RS00080	COG0195	Participates in both transcription termination and antitermination
D4K63_RS00085	COG1921	L-seryl-tRNASec selenium transferase activity
D4K63_RS00105	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D4K63_RS00110	COG0348	domain, Protein
D4K63_RS00120	COG0786	glutamate:sodium symporter activity
D4K63_RS00130	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D4K63_RS00135	COG2217	Heavy metal translocating P-type atpase
D4K63_RS00170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D4K63_RS00175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D4K63_RS00185	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D4K63_RS00190	COG0306	phosphate transporter
D4K63_RS00195	COG1253	flavin adenine dinucleotide binding
D4K63_RS00205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D4K63_RS00220	COG1739	Uncharacterized protein family UPF0029
D4K63_RS00225	COG1981	membrane
D4K63_RS00230	COG2226	methyltransferase
D4K63_RS00255	COG0210	DNA helicase
D4K63_RS00265	COG0163	prenyltransferase activity
D4K63_RS00270	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D4K63_RS00275	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D4K63_RS00295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D4K63_RS00295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D4K63_RS00305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D4K63_RS00315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D4K63_RS00320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D4K63_RS00345	COG0587	DNA-directed DNA polymerase activity
D4K63_RS00350	COG1187	pseudouridine synthase activity
D4K63_RS00355	COG3118	belongs to the thioredoxin family
D4K63_RS00390	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D4K63_RS00400	COG0706	membrane insertase activity
D4K63_RS00420	COG0848	biopolymer transport protein
D4K63_RS00425	COG0811	peptide transport
D4K63_RS00435	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D4K63_RS00445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D4K63_RS00495	COG0788	formyltetrahydrofolate deformylase activity
D4K63_RS00520	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D4K63_RS00525	COG0517	IMP dehydrogenase activity
D4K63_RS00525	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D4K63_RS00550	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D4K63_RS00560	COG4962	Type ii secretion system protein e
D4K63_RS00565	COG1157	protein secretion by the type III secretion system
D4K63_RS00570	COG1987	bacterial-type flagellum assembly
D4K63_RS00575	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D4K63_RS00595	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D4K63_RS00600	COG0799	negative regulation of ribosome biogenesis
D4K63_RS00605	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D4K63_RS00645	COG1295	ribonuclease BN
D4K63_RS00680	COG0010	Belongs to the arginase family
D4K63_RS00685	COG0686	Belongs to the AlaDH PNT family
D4K63_RS00705	COG0497	DNA recombination
D4K63_RS00745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D4K63_RS00770	COG0287	Prephenate dehydrogenase
D4K63_RS00775	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D4K63_RS00780	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D4K63_RS00785	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
D4K63_RS00795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D4K63_RS00805	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D4K63_RS00810	COG1077	Cell shape determining protein MreB Mrl
D4K63_RS00825	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D4K63_RS00830	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D4K63_RS00845	COG0745	RESPONSE REGULATOR receiver
D4K63_RS00850	COG0642	Histidine kinase
D4K63_RS00855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D4K63_RS00855	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D4K63_RS00860	COG0305	Participates in initiation and elongation during chromosome replication
D4K63_RS00870	COG0109	protoheme IX farnesyltransferase activity
D4K63_RS00890	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D4K63_RS00895	COG0157	Belongs to the NadC ModD family
D4K63_RS00915	COG0793	Belongs to the peptidase S41A family
D4K63_RS00925	COG0204	Acyl-transferase
D4K63_RS00940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D4K63_RS00945	COG0126	phosphoglycerate kinase activity
D4K63_RS00950	COG0598	Magnesium transport protein CorA
D4K63_RS00955	COG0861	Integral membrane protein TerC family
D4K63_RS00965	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D4K63_RS00970	COG0848	biopolymer transport protein
D4K63_RS00975	COG0811	peptide transport
D4K63_RS00980	COG0864	Transcriptional regulator
D4K63_RS00995	COG0482	sulfurtransferase activity
D4K63_RS01010	COG0484	heat shock protein binding
D4K63_RS01015	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D4K63_RS01020	COG1687	branched-chain amino acid
D4K63_RS01025	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D4K63_RS01050	COG0114	fumarate hydratase activity
D4K63_RS01080	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D4K63_RS01105	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D4K63_RS01175	COG0201	protein transport
D4K63_RS01180	COG0024	Methionine aminopeptidase
D4K63_RS01185	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D4K63_RS01200	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D4K63_RS01210	COG0202	RNA polymerase activity
D4K63_RS01245	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D4K63_RS01250	COG2353	YceI-like domain
D4K63_RS01260	COG0859	PFAM glycosyl transferase family 9
D4K63_RS01295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D4K63_RS01300	COG0512	Glutamine amidotransferase of anthranilate synthase
D4K63_RS01310	COG0135	phosphoribosylanthranilate isomerase activity
D4K63_RS01310	COG0134	indole-3-glycerol-phosphate synthase activity
D4K63_RS01315	COG0133	tryptophan synthase activity
D4K63_RS01340	COG1007	ATP synthesis coupled electron transport
D4K63_RS01350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D4K63_RS01360	COG0839	Belongs to the complex I subunit 6 family
D4K63_RS01365	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D4K63_RS01370	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D4K63_RS01405	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D4K63_RS01410	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D4K63_RS01420	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D4K63_RS01425	COG0233	cytoplasmic translational termination
D4K63_RS01430	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D4K63_RS01440	COG0180	Tryptophanyl-tRNA synthetase
D4K63_RS01445	COG4166	transmembrane transport
D4K63_RS01450	COG4174	ABC transporter (Permease)
D4K63_RS01465	COG0557	exoribonuclease II activity
D4K63_RS01470	COG1466	dna polymerase III delta subunit
D4K63_RS01480	COG0629	single-stranded DNA binding
D4K63_RS01505	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D4K63_RS01525	COG0505	Belongs to the CarA family
D4K63_RS01540	COG0697	spore germination
D4K63_RS01550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D4K63_RS01565	COG0527	aspartate kinase activity
D4K63_RS01575	COG2863	cytochrome
D4K63_RS01580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D4K63_RS01585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D4K63_RS01605	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D4K63_RS01610	COG1131	(ABC) transporter
D4K63_RS01620	COG0151	Belongs to the GarS family
D4K63_RS01630	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D4K63_RS01660	COG1045	serine acetyltransferase
D4K63_RS01680	COG1132	(ABC) transporter
D4K63_RS01705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D4K63_RS01725	COG0250	Participates in transcription elongation, termination and antitermination
D4K63_RS01770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D4K63_RS01775	COG0667	Aldo Keto reductase
D4K63_RS01790	COG0859	PFAM glycosyl transferase family 9
D4K63_RS01800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D4K63_RS01830	COG0475	glutathione-regulated potassium exporter activity
D4K63_RS01830	COG0569	domain protein
D4K63_RS01835	COG0037	tRNA processing
D4K63_RS01840	COG2814	Major facilitator Superfamily
D4K63_RS01850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D4K63_RS01855	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D4K63_RS01875	COG2252	PERMEase
D4K63_RS01880	COG0738	Major facilitator superfamily
D4K63_RS01895	COG1126	abc transporter atp-binding protein
D4K63_RS01900	COG0765	amino acid transport
D4K63_RS01910	COG1966	Carbon starvation protein
D4K63_RS01945	COG0716	FMN binding
D4K63_RS01955	COG2184	nucleotidyltransferase activity
D4K63_RS01960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D4K63_RS01985	COG0525	valine-tRNA ligase activity
D4K63_RS01990	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D4K63_RS02005	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D4K63_RS02010	COG0336	Belongs to the RNA methyltransferase TrmD family
D4K63_RS02055	COG1192	Involved in chromosome partitioning
D4K63_RS02060	COG1475	DNA binding
D4K63_RS02085	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D4K63_RS02095	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D4K63_RS02100	COG0811	peptide transport
D4K63_RS02105	COG0848	biopolymer transport protein
D4K63_RS02120	COG2885	chlorophyll binding
D4K63_RS02130	COG1047	Peptidyl-prolyl cis-trans
D4K63_RS02160	COG0405	Gamma-glutamyltransferase
D4K63_RS02225	COG0753	catalase activity
D4K63_RS02240	COG2824	Alkylphosphonate utilization operon protein PhnA
D4K63_RS02250	COG2134	cdp-diacylglycerol pyrophosphatase
D4K63_RS02255	COG1749	Flagellar hook protein flgE
D4K63_RS02260	COG0375	protein maturation
D4K63_RS02270	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D4K63_RS02280	COG0756	dUTP diphosphatase activity
D4K63_RS02295	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D4K63_RS02305	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D4K63_RS02310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D4K63_RS02320	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D4K63_RS02330	COG0516	GMP reductase activity
D4K63_RS02335	COG0488	(ABC) transporter
D4K63_RS02345	COG0671	phosphoesterase, PA-phosphatase related
D4K63_RS02370	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D4K63_RS02375	COG0351	phosphomethylpyrimidine kinase
D4K63_RS02390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D4K63_RS02395	COG1086	Polysaccharide biosynthesis protein
D4K63_RS02420	COG0776	regulation of translation
D4K63_RS02440	COG0237	dephospho-CoA kinase activity
D4K63_RS02450	COG0517	IMP dehydrogenase activity
D4K63_RS02450	COG0516	GMP reductase activity
D4K63_RS02460	COG0724	RNA recognition motif
D4K63_RS02470	COG0492	ferredoxin-NADP+ reductase activity
D4K63_RS02475	COG3118	belongs to the thioredoxin family
D4K63_RS02480	COG0792	nuclease activity
D4K63_RS02485	COG0460	homoserine dehydrogenase
D4K63_RS02490	COG0322	excinuclease ABC activity
D4K63_RS02505	COG0517	IMP dehydrogenase activity
D4K63_RS02505	COG1125	glycine betaine transport
D4K63_RS02510	COG1732	Glycine betaine
D4K63_RS02520	COG1360	Flagellar Motor Protein
D4K63_RS02525	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D4K63_RS02530	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D4K63_RS02535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D4K63_RS02555	COG1580	Controls the rotational direction of flagella during chemotaxis
D4K63_RS02580	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D4K63_RS02580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D4K63_RS02600	COG0314	molybdopterin synthase activity
D4K63_RS02605	COG0521	Mo-molybdopterin cofactor biosynthetic process
D4K63_RS02630	COG0740	serine-type endopeptidase activity
D4K63_RS02640	COG0606	chelatase, subunit chli
D4K63_RS02645	COG2217	Heavy metal translocating P-type atpase
D4K63_RS02650	COG0732	type I restriction modification DNA specificity domain
D4K63_RS02670	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D4K63_RS02700	COG1049	propionate catabolic process, 2-methylcitrate cycle
D4K63_RS02710	COG0528	UMP kinase activity
D4K63_RS02715	COG1758	RNA polymerase activity
D4K63_RS02725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D4K63_RS02735	COG0860	N-Acetylmuramoyl-L-alanine amidase
D4K63_RS02745	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D4K63_RS02765	COG0552	protein localization to endoplasmic reticulum
D4K63_RS02785	COG0534	Mate efflux family protein
D4K63_RS02790	COG2056	Na+-H+ antiporter family
D4K63_RS02840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D4K63_RS02855	COG0564	pseudouridine synthase activity
D4K63_RS02860	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D4K63_RS02870	COG0772	Belongs to the SEDS family
D4K63_RS02880	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D4K63_RS02890	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D4K63_RS02900	COG1181	Belongs to the D-alanine--D-alanine ligase family
D4K63_RS02905	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D4K63_RS02910	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D4K63_RS02915	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D4K63_RS02920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D4K63_RS02950	COG0037	tRNA processing
D4K63_RS02955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D4K63_RS02970	COG0252	asparaginase activity
D4K63_RS02975	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D4K63_RS03000	COG1279	arginine transmembrane transporter activity
D4K63_RS03005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D4K63_RS03015	COG1137	ATPase activity
D4K63_RS03020	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D4K63_RS03025	COG3177	Filamentation induced by cAMP protein fic
D4K63_RS03040	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
D4K63_RS03050	COG0275	rRNA processing
D4K63_RS03060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D4K63_RS03070	COG2204	response regulator
D4K63_RS03080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D4K63_RS03085	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D4K63_RS03100	COG4647	ligase activity
D4K63_RS03105	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
D4K63_RS03110	COG0145	ligase activity
D4K63_RS03120	COG2031	fatty acid transporter
D4K63_RS03125	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D4K63_RS03130	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D4K63_RS03135	COG0183	Belongs to the thiolase family
D4K63_RS03145	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D4K63_RS03155	COG1338	Plays a role in the flagellum-specific transport system
D4K63_RS03165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D4K63_RS03180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D4K63_RS03190	COG0730	response to heat
D4K63_RS03200	COG4974	Belongs to the 'phage' integrase family
D4K63_RS03240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D4K63_RS03255	COG0571	ribonuclease III activity
D4K63_RS03260	COG0328	RNA-DNA hybrid ribonuclease activity
D4K63_RS03275	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D4K63_RS03285	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D4K63_RS03290	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D4K63_RS03295	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D4K63_RS03300	COG1528	Iron-storage protein
D4K63_RS03305	COG0560	Phosphoserine phosphatase
D4K63_RS03320	COG1027	Aspartate ammonia-lyase
D4K63_RS03355	COG0778	Nitroreductase
D4K63_RS03360	COG2084	Dehydrogenase
D4K63_RS03390	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D4K63_RS03395	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D4K63_RS03400	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
D4K63_RS03405	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D4K63_RS03410	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D4K63_RS03415	COG2249	NAD(P)H dehydrogenase (quinone) activity
D4K63_RS03430	COG2171	N-acyltransferase activity
D4K63_RS03440	COG0436	Aminotransferase
D4K63_RS03445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D4K63_RS03455	COG1193	negative regulation of DNA recombination
D4K63_RS03460	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D4K63_RS03475	COG0563	adenylate kinase activity
D4K63_RS03485	COG0835	chemotaxis
D4K63_RS03485	COG0784	Response regulator, receiver
D4K63_RS03500	COG1131	(ABC) transporter
D4K63_RS03540	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D4K63_RS03555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D4K63_RS03570	COG0840	transmembrane signaling receptor activity
D4K63_RS03575	COG0156	8-amino-7-oxononanoate synthase activity
D4K63_RS03580	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D4K63_RS03625	COG1013	pyruvate-flavodoxin oxidoreductase activity
D4K63_RS03630	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D4K63_RS03630	COG0674	pyruvate-flavodoxin oxidoreductase activity
D4K63_RS03650	COG1918	ferrous iron import across plasma membrane
D4K63_RS03655	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D4K63_RS03660	COG1776	CheC inhibitor of MCP methylation
D4K63_RS03660	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D4K63_RS03700	COG0681	Belongs to the peptidase S26 family
D4K63_RS03705	COG1994	Peptidase M50
D4K63_RS03710	COG0698	ribose 5-phosphate isomerase
D4K63_RS03735	COG0012	GTP binding
D4K63_RS03745	COG0628	permease
D4K63_RS03775	COG1028	Short-chain dehydrogenase reductase Sdr
D4K63_RS03780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D4K63_RS03785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D4K63_RS03815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D4K63_RS03820	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D4K63_RS03830	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D4K63_RS03860	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D4K63_RS03865	COG0359	binds to the 23S rRNA
D4K63_RS03870	COG3586	endonuclease activity
D4K63_RS03875	COG0174	glutamine synthetase
D4K63_RS03890	COG0277	FAD linked oxidase domain protein
D4K63_RS03905	COG0741	lytic transglycosylase activity
D4K63_RS03905	COG1196	nuclear chromosome segregation
D4K63_RS03905	COG0739	heme binding
D4K63_RS03920	COG0187	DNA topoisomerase II activity
D4K63_RS03925	COG0592	DNA-directed DNA polymerase activity
D4K63_RS03935	COG0733	neurotransmitter:sodium symporter activity
D4K63_RS03940	COG0733	neurotransmitter:sodium symporter activity
D4K63_RS03945	COG0824	Thioesterase
D4K63_RS04045	COG1217	gtp-binding protein TYPA
D4K63_RS04100	COG0475	glutathione-regulated potassium exporter activity
D4K63_RS04100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D4K63_RS04155	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D4K63_RS04170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D4K63_RS04175	COG1028	Short-chain dehydrogenase reductase Sdr
D4K63_RS04185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D4K63_RS04190	COG0833	amino acid
D4K63_RS04205	COG0745	RESPONSE REGULATOR receiver
D4K63_RS04235	COG0484	heat shock protein binding
D4K63_RS04240	COG0789	Transcriptional regulator
D4K63_RS04245	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D4K63_RS04245	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D4K63_RS04250	COG0735	belongs to the Fur family
D4K63_RS04265	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D4K63_RS04265	COG1776	CheC inhibitor of MCP methylation
D4K63_RS04270	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D4K63_RS04285	COG0455	bacterial-type flagellum organization
D4K63_RS04290	COG1419	protein localization to endoplasmic reticulum
D4K63_RS04295	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D4K63_RS04300	COG0006	proline dipeptidase activity
D4K63_RS04315	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D4K63_RS04320	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D4K63_RS04325	COG2404	hydrolase activity, acting on ester bonds
D4K63_RS04330	COG0745	RESPONSE REGULATOR receiver
D4K63_RS04335	COG1408	metallophosphoesterase
D4K63_RS04365	COG0083	homoserine kinase activity
D4K63_RS04420	COG0805	protein transport
D4K63_RS04430	COG0357	Ribosomal RNA small subunit methyltransferase G
D4K63_RS04455	COG0745	RESPONSE REGULATOR receiver
D4K63_RS04460	COG2264	protein methyltransferase activity
D4K63_RS04465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D4K63_RS04475	COG1183	phosphatidylcholine synthase activity
D4K63_RS04485	COG2608	mercury ion transmembrane transporter activity
D4K63_RS04500	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
D4K63_RS04510	COG1106	Psort location Cytoplasmic, score
D4K63_RS04525	COG1132	(ABC) transporter
D4K63_RS04545	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D4K63_RS04550	COG0196	riboflavin kinase activity
D4K63_RS04555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D4K63_RS04565	COG1674	ftsk spoiiie
D4K63_RS04575	COG0477	Major facilitator Superfamily
D4K63_RS04580	COG4786	Flagellar basal body rod
D4K63_RS04615	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D4K63_RS04620	COG0800	Aldolase
D4K63_RS04625	COG0129	dihydroxy-acid dehydratase activity
D4K63_RS04630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D4K63_RS04635	COG0363	glucosamine-6-phosphate deaminase activity
D4K63_RS04640	COG0837	glucose binding
D4K63_RS04645	COG1064	alcohol dehydrogenase
D4K63_RS04665	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D4K63_RS04675	COG0674	pyruvate-flavodoxin oxidoreductase activity
D4K63_RS04680	COG1013	pyruvate-flavodoxin oxidoreductase activity
D4K63_RS04685	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D4K63_RS04715	COG0632	four-way junction helicase activity
D4K63_RS04725	COG0728	peptidoglycan biosynthetic process
D4K63_RS04730	COG0215	cysteine-tRNA ligase activity
D4K63_RS04745	COG1120	ATPase activity
D4K63_RS04750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D4K63_RS04755	COG0300	oxidoreductase activity
D4K63_RS04760	COG1607	acyl-coa hydrolase
D4K63_RS04795	COG0409	Hydrogenase expression formation protein
D4K63_RS04800	COG0298	carbon dioxide binding
D4K63_RS04805	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D4K63_RS04825	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D4K63_RS04840	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D4K63_RS04845	COG1749	Flagellar hook protein flgE
D4K63_RS04845	COG1749	Flagellar hook protein flgE
D4K63_RS04895	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D4K63_RS04900	COG0670	Belongs to the BI1 family
D4K63_RS04905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D4K63_RS04920	COG1942	4-Oxalocrotonate Tautomerase
D4K63_RS04930	COG0585	pseudouridine synthase activity
D4K63_RS04935	COG0501	Belongs to the peptidase M48B family
D4K63_RS04945	COG0142	geranyltranstransferase activity
D4K63_RS04960	COG0720	synthase
D4K63_RS04965	COG0602	queuosine metabolic process
D4K63_RS04980	COG0477	Major facilitator Superfamily
D4K63_RS04995	COG0765	amino acid transport
D4K63_RS05000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D4K63_RS05010	COG1115	amino acid carrier protein
D4K63_RS05015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D4K63_RS05020	COG0251	oxidation-reduction process
D4K63_RS05045	COG1757	Na H antiporter
D4K63_RS05070	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D4K63_RS05080	COG1546	Belongs to the CinA family
D4K63_RS05080	COG1058	Belongs to the CinA family
D4K63_RS05110	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D4K63_RS05115	COG0564	pseudouridine synthase activity
D4K63_RS05120	COG1519	Transferase
D4K63_RS05130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D4K63_RS05140	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D4K63_RS05165	COG3309	Virulence-associated protein D
D4K63_RS05190	COG0751	glycine-tRNA ligase activity
D4K63_RS05200	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D4K63_RS05210	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D4K63_RS05220	COG0849	cell division
D4K63_RS05225	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D4K63_RS05265	COG0668	transmembrane transport
D4K63_RS05380	COG1166	arginine decarboxylase activity
D4K63_RS05395	COG0500	methyltransferase
D4K63_RS05405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D4K63_RS05405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D4K63_RS05410	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D4K63_RS05415	COG0668	transmembrane transport
D4K63_RS05465	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D4K63_RS05470	COG0537	adenosine 5'-monophosphoramidase activity
D4K63_RS05480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D4K63_RS05480	COG0072	phenylalanine-tRNA ligase activity
D4K63_RS05495	COG0539	negative regulation of cytoplasmic translation
D4K63_RS05495	COG1185	polyribonucleotide nucleotidyltransferase activity
D4K63_RS05505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D4K63_RS05510	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D4K63_RS05515	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D4K63_RS05525	COG0784	Response regulator, receiver
D4K63_RS05525	COG0835	chemotaxis
D4K63_RS05530	COG0784	Response regulator, receiver
D4K63_RS05530	COG0643	Histidine kinase
D4K63_RS05530	COG2198	Histidine kinase
D4K63_RS05535	COG0835	chemotaxis
D4K63_RS05540	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D4K63_RS05545	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D4K63_RS05555	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D4K63_RS05580	COG0501	Belongs to the peptidase M48B family
D4K63_RS05585	COG2890	protein-(glutamine-N5) methyltransferase activity
D4K63_RS05590	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D4K63_RS05600	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D4K63_RS05600	COG1333	cytochrome c biogenesis protein
D4K63_RS05620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D4K63_RS05635	COG0511	ligase activity, forming carbon-carbon bonds
D4K63_RS05640	COG0439	Biotin carboxylase
D4K63_RS05660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D4K63_RS05670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D4K63_RS05675	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D4K63_RS05710	COG4221	oxidoreductase activity
D4K63_RS05725	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D4K63_RS05735	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D4K63_RS05740	COG1766	The M ring may be actively involved in energy transduction
D4K63_RS05755	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D4K63_RS05755	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D4K63_RS05760	COG0564	pseudouridine synthase activity
D4K63_RS05820	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D4K63_RS05820	COG0758	DNA mediated transformation
D4K63_RS05830	COG2894	cell division
D4K63_RS05835	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D4K63_RS05845	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D4K63_RS05855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D4K63_RS05860	COG3980	spore coat polysaccharide biosynthesis protein
D4K63_RS05865	COG3980	spore coat polysaccharide biosynthesis protein
D4K63_RS05870	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D4K63_RS05895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D4K63_RS05905	COG0748	coenzyme F420 binding
D4K63_RS05940	COG0523	cobalamin synthesis protein
D4K63_RS05950	COG0726	polysaccharide deacetylase
D4K63_RS05955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D4K63_RS05990	COG4608	Belongs to the ABC transporter superfamily
D4K63_RS05995	COG0444	Belongs to the ABC transporter superfamily
D4K63_RS06000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D4K63_RS06005	COG0601	transmembrane transport
D4K63_RS06010	COG0747	negative chemotaxis
D4K63_RS06035	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D4K63_RS06050	COG0019	diaminopimelate decarboxylase activity
D4K63_RS06070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D4K63_RS06075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D4K63_RS06095	COG0343	queuine tRNA-ribosyltransferase activity
D4K63_RS06105	COG0859	PFAM glycosyl transferase family 9
D4K63_RS06110	COG0248	Ppx GppA phosphatase
D4K63_RS06120	COG0134	indole-3-glycerol-phosphate synthase activity
D4K63_RS06130	COG0727	PFAM Uncharacterised protein family (UPF0153)
D4K63_RS06165	COG0402	S-adenosylhomocysteine deaminase activity
D4K63_RS06170	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D4K63_RS06175	COG0785	Cytochrome C biogenesis protein
D4K63_RS06180	COG0542	response to heat
D4K63_RS06210	COG0750	zinc metalloprotease
D4K63_RS06245	COG4239	(ABC) transporter, permease
D4K63_RS06250	COG4172	Belongs to the ABC transporter superfamily
D4K63_RS06275	COG3951	Flagellar rod assembly protein muramidase FlgJ
D4K63_RS06280	COG0642	Histidine kinase
D4K63_RS06285	COG0783	Belongs to the Dps family
D4K63_RS06300	COG0142	geranyltranstransferase activity
D4K63_RS06310	COG0442	prolyl-tRNA aminoacylation
D4K63_RS06325	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D4K63_RS06335	COG0754	glutathionylspermidine amidase activity
D4K63_RS06365	COG0659	secondary active sulfate transmembrane transporter activity
D4K63_RS06375	COG0730	response to heat
D4K63_RS06380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D4K63_RS06380	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D4K63_RS06385	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D4K63_RS06410	COG1881	PFAM PEBP family protein
D4K63_RS06415	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D4K63_RS06420	COG0575	Belongs to the CDS family
D4K63_RS06425	COG0471	metal ion transport
D4K63_RS06440	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D4K63_RS06445	COG0326	Molecular chaperone. Has ATPase activity
D4K63_RS06465	COG0489	protein tyrosine kinase activity
D4K63_RS06525	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D4K63_RS06530	COG0149	triose-phosphate isomerase activity
D4K63_RS06540	COG1053	succinate dehydrogenase
D4K63_RS06545	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D4K63_RS06550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D4K63_RS06600	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D4K63_RS06605	COG1136	(ABC) transporter
D4K63_RS06610	COG2089	acid synthase
D4K63_RS06620	COG0191	fructose-bisphosphate aldolase activity
D4K63_RS06625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D4K63_RS06645	COG0303	'Molybdopterin
D4K63_RS06660	COG0826	peptidase U32
D4K63_RS06675	COG0745	RESPONSE REGULATOR receiver
D4K63_RS06685	COG0113	porphobilinogen synthase activity
D4K63_RS06690	COG0217	transcriptional regulatory protein
D4K63_RS06715	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D4K63_RS06745	COG0148	phosphopyruvate hydratase activity
D4K63_RS06795	COG3278	Belongs to the heme-copper respiratory oxidase family
D4K63_RS06800	COG0471	metal ion transport
D4K63_RS06805	COG1194	a g-specific adenine glycosylase
D4K63_RS06810	COG1620	l-lactate permease
D4K63_RS06815	COG1620	l-lactate permease
D4K63_RS06820	COG0247	lactate metabolic process
D4K63_RS06825	COG1139	Iron-sulfur cluster binding protein
D4K63_RS06835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D4K63_RS06845	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D4K63_RS06855	COG1760	l-serine dehydratase
D4K63_RS06885	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D4K63_RS06900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D4K63_RS06900	COG0574	Belongs to the PEP-utilizing enzyme family
D4K63_RS06910	COG0731	radical SAM domain protein
D4K63_RS06915	COG0551	DNA topoisomerase type I activity
D4K63_RS06915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D4K63_RS06920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D4K63_RS06940	COG1420	regulation of RNA biosynthetic process
D4K63_RS06960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D4K63_RS06965	COG0626	cystathionine gamma-synthase activity
D4K63_RS06975	COG0737	Belongs to the 5'-nucleotidase family
D4K63_RS06985	COG1216	Glycosyl transferase, family 2
D4K63_RS06995	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D4K63_RS07005	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D4K63_RS07015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D4K63_RS07050	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D4K63_RS07055	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D4K63_RS07060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D4K63_RS07090	COG0840	transmembrane signaling receptor activity
D4K63_RS07130	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D4K63_RS07145	COG0804	urea catabolic process
D4K63_RS07160	COG0830	nickel cation binding
D4K63_RS07170	COG0829	nickel cation binding
D4K63_RS07235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D4K63_RS07285	COG2957	Belongs to the agmatine deiminase family
D4K63_RS07290	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D4K63_RS07305	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D4K63_RS07355	COG0542	response to heat
D4K63_RS07360	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D4K63_RS07365	COG0589	response to stress
D4K63_RS07385	COG0538	isocitrate dehydrogenase activity
D4K63_RS07390	COG0372	Belongs to the citrate synthase family
D4K63_RS07405	COG2194	sulfuric ester hydrolase activity
D4K63_RS07410	COG0671	phosphoesterase, PA-phosphatase related
D4K63_RS07420	COG0835	chemotaxis
D4K63_RS07420	COG0784	Response regulator, receiver
D4K63_RS07455	COG0482	sulfurtransferase activity
D4K63_RS07460	COG0358	DNA primase activity
D4K63_RS07515	COG0284	orotidine-5'-phosphate decarboxylase activity
D4K63_RS07520	COG0288	reversible hydration of carbon dioxide
D4K63_RS07545	COG4735	regulation of single-species biofilm formation
D4K63_RS07560	COG4735	regulation of single-species biofilm formation
D4K63_RS07570	COG4786	Flagellar basal body rod
D4K63_RS07575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D4K63_RS07590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D4K63_RS07595	COG0671	phosphoesterase, PA-phosphatase related
D4K63_RS07610	COG2011	ABC-type metal ion transport system permease component
D4K63_RS07615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D4K63_RS07625	COG0307	riboflavin synthase, alpha
D4K63_RS07630	COG0084	hydrolase, TatD family'
D4K63_RS07635	COG1388	LysM domain
D4K63_RS07635	COG0741	lytic transglycosylase activity
D4K63_RS07640	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D4K63_RS07645	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D4K63_RS07670	COG0768	penicillin binding
D4K63_RS07680	COG0450	alkyl hydroperoxide reductase
D4K63_RS07695	COG0772	Belongs to the SEDS family
D4K63_RS07700	COG1815	bacterial-type flagellum-dependent cell motility
D4K63_RS07705	COG1558	bacterial-type flagellum-dependent cell motility
D4K63_RS07720	COG0768	penicillin binding
D4K63_RS07725	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D4K63_RS07735	COG1074	ATP-dependent DNA helicase activity
D4K63_RS07745	COG1862	Preprotein translocase
D4K63_RS07750	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D4K63_RS07755	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D4K63_RS07775	COG0285	dihydrofolate synthase activity
D4K63_RS07785	COG0739	heme binding
D4K63_RS07795	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D4K63_RS07800	COG0723	plastoquinol--plastocyanin reductase activity
D4K63_RS07840	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D4K63_RS07845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity