locus-tag	class	description
HPKB_RS00015	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPKB_RS00020	COG0288	reversible hydration of carbon dioxide
HPKB_RS00070	COG0459	protein refolding
HPKB_RS00085	COG0482	sulfurtransferase activity
HPKB_RS00115	COG0784	Response regulator, receiver
HPKB_RS00115	COG0835	chemotaxis
HPKB_RS00125	COG0671	phosphoesterase, PA-phosphatase related
HPKB_RS00130	COG2194	sulfuric ester hydrolase activity
HPKB_RS00145	COG0287	Prephenate dehydrogenase
HPKB_RS00150	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPKB_RS00155	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPKB_RS00165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPKB_RS00175	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPKB_RS00180	COG1077	Cell shape determining protein MreB Mrl
HPKB_RS00190	COG0745	RESPONSE REGULATOR receiver
HPKB_RS00195	COG0642	Histidine kinase
HPKB_RS00200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPKB_RS00200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPKB_RS00205	COG0305	Participates in initiation and elongation during chromosome replication
HPKB_RS00215	COG0109	protoheme IX farnesyltransferase activity
HPKB_RS00235	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPKB_RS00240	COG0157	Belongs to the NadC ModD family
HPKB_RS00260	COG0793	Belongs to the peptidase S41A family
HPKB_RS00270	COG0204	Acyl-transferase
HPKB_RS00280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPKB_RS00285	COG0126	phosphoglycerate kinase activity
HPKB_RS00290	COG0598	Magnesium transport protein CorA
HPKB_RS00295	COG0861	Integral membrane protein TerC family
HPKB_RS00325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPKB_RS00330	COG0506	proline dehydrogenase activity
HPKB_RS00330	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPKB_RS00330	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPKB_RS00405	COG0830	nickel cation binding
HPKB_RS00440	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPKB_RS00455	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPKB_RS00480	COG0840	transmembrane signaling receptor activity
HPKB_RS00500	COG0579	oxidoreductase
HPKB_RS00510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPKB_RS00515	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPKB_RS00520	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPKB_RS00555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPKB_RS00565	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPKB_RS00570	COG0840	transmembrane signaling receptor activity
HPKB_RS00575	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPKB_RS00590	COG0840	transmembrane signaling receptor activity
HPKB_RS00595	COG0737	Belongs to the 5'-nucleotidase family
HPKB_RS00605	COG0626	cystathionine gamma-synthase activity
HPKB_RS00610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPKB_RS00625	COG1420	regulation of RNA biosynthetic process
HPKB_RS00645	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPKB_RS00650	COG0551	DNA topoisomerase type I activity
HPKB_RS00650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPKB_RS00655	COG0731	radical SAM domain protein
HPKB_RS00665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPKB_RS00665	COG0574	Belongs to the PEP-utilizing enzyme family
HPKB_RS00680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HPKB_RS00715	COG1760	l-serine dehydratase
HPKB_RS00720	COG0814	amino acid
HPKB_RS00725	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HPKB_RS00735	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPKB_RS00745	COG1139	Iron-sulfur cluster binding protein
HPKB_RS00750	COG0247	lactate metabolic process
HPKB_RS00755	COG1620	l-lactate permease
HPKB_RS00760	COG1620	l-lactate permease
HPKB_RS00765	COG1194	a g-specific adenine glycosylase
HPKB_RS00770	COG0471	metal ion transport
HPKB_RS00775	COG3278	Belongs to the heme-copper respiratory oxidase family
HPKB_RS00825	COG0148	phosphopyruvate hydratase activity
HPKB_RS00855	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPKB_RS00865	COG0113	porphobilinogen synthase activity
HPKB_RS00870	COG0642	Histidine kinase
HPKB_RS00875	COG0745	RESPONSE REGULATOR receiver
HPKB_RS00890	COG0826	peptidase U32
HPKB_RS00910	COG0303	'Molybdopterin
HPKB_RS00925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPKB_RS00930	COG0191	fructose-bisphosphate aldolase activity
HPKB_RS00955	COG2089	acid synthase
HPKB_RS00960	COG1136	(ABC) transporter
HPKB_RS00965	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPKB_RS01015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPKB_RS01020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPKB_RS01025	COG1053	succinate dehydrogenase
HPKB_RS01040	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPKB_RS01045	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPKB_RS01095	COG0489	protein tyrosine kinase activity
HPKB_RS01115	COG0326	Molecular chaperone. Has ATPase activity
HPKB_RS01120	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPKB_RS01135	COG0471	metal ion transport
HPKB_RS01140	COG0575	Belongs to the CDS family
HPKB_RS01160	COG1881	PFAM PEBP family protein
HPKB_RS01170	COG1104	cysteine desulfurase activity
HPKB_RS01185	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPKB_RS01190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPKB_RS01190	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPKB_RS01195	COG0730	response to heat
HPKB_RS01205	COG0659	secondary active sulfate transmembrane transporter activity
HPKB_RS01235	COG0754	glutathionylspermidine amidase activity
HPKB_RS01245	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPKB_RS01255	COG0181	hydroxymethylbilane synthase activity
HPKB_RS01285	COG0783	Belongs to the Dps family
HPKB_RS01290	COG0642	Histidine kinase
HPKB_RS01295	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPKB_RS01320	COG4172	Belongs to the ABC transporter superfamily
HPKB_RS01325	COG4239	(ABC) transporter, permease
HPKB_RS01360	COG0750	zinc metalloprotease
HPKB_RS01390	COG0542	response to heat
HPKB_RS01395	COG0785	Cytochrome C biogenesis protein
HPKB_RS01400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPKB_RS01405	COG0402	S-adenosylhomocysteine deaminase activity
HPKB_RS01440	COG0727	PFAM Uncharacterised protein family (UPF0153)
HPKB_RS01450	COG0134	indole-3-glycerol-phosphate synthase activity
HPKB_RS01460	COG0248	Ppx GppA phosphatase
HPKB_RS01465	COG0859	PFAM glycosyl transferase family 9
HPKB_RS01495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPKB_RS01500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPKB_RS01520	COG0019	diaminopimelate decarboxylase activity
HPKB_RS01560	COG0747	negative chemotaxis
HPKB_RS01565	COG0601	transmembrane transport
HPKB_RS01570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPKB_RS01575	COG0444	Belongs to the ABC transporter superfamily
HPKB_RS01580	COG4608	Belongs to the ABC transporter superfamily
HPKB_RS01615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPKB_RS01620	COG0726	polysaccharide deacetylase
HPKB_RS01630	COG0523	cobalamin synthesis protein
HPKB_RS01640	COG0748	coenzyme F420 binding
HPKB_RS01675	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPKB_RS01680	COG3980	spore coat polysaccharide biosynthesis protein
HPKB_RS01685	COG3980	spore coat polysaccharide biosynthesis protein
HPKB_RS01690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPKB_RS01695	COG1663	tetraacyldisaccharide 4'-kinase activity
HPKB_RS01715	COG2894	cell division
HPKB_RS01725	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPKB_RS01725	COG0758	DNA mediated transformation
HPKB_RS01730	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPKB_RS01785	COG0564	pseudouridine synthase activity
HPKB_RS01790	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPKB_RS01790	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HPKB_RS01795	COG0504	CTP synthase activity
HPKB_RS01805	COG1766	The M ring may be actively involved in energy transduction
HPKB_RS01810	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPKB_RS01820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPKB_RS01845	COG4786	Flagellar basal body rod
HPKB_RS01850	COG0477	Major facilitator Superfamily
HPKB_RS01855	COG1674	ftsk spoiiie
HPKB_RS01865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPKB_RS01870	COG0196	riboflavin kinase activity
HPKB_RS01895	COG1132	(ABC) transporter
HPKB_RS01910	COG1106	Psort location Cytoplasmic, score
HPKB_RS01920	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HPKB_RS01940	COG2608	mercury ion transmembrane transporter activity
HPKB_RS01945	COG2217	Heavy metal translocating P-type atpase
HPKB_RS01950	COG1183	phosphatidylcholine synthase activity
HPKB_RS01960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPKB_RS01970	COG0745	RESPONSE REGULATOR receiver
HPKB_RS01995	COG0357	Ribosomal RNA small subunit methyltransferase G
HPKB_RS02005	COG0805	protein transport
HPKB_RS02050	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPKB_RS02060	COG0083	homoserine kinase activity
HPKB_RS02090	COG1408	metallophosphoesterase
HPKB_RS02095	COG0745	RESPONSE REGULATOR receiver
HPKB_RS02100	COG2404	hydrolase activity, acting on ester bonds
HPKB_RS02105	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPKB_RS02125	COG0006	proline dipeptidase activity
HPKB_RS02130	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPKB_RS02140	COG0455	bacterial-type flagellum organization
HPKB_RS02155	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPKB_RS02160	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPKB_RS02160	COG1776	CheC inhibitor of MCP methylation
HPKB_RS02175	COG0735	belongs to the Fur family
HPKB_RS02180	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HPKB_RS02180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPKB_RS02185	COG0789	Transcriptional regulator
HPKB_RS02190	COG0484	heat shock protein binding
HPKB_RS02205	COG0745	RESPONSE REGULATOR receiver
HPKB_RS02210	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPKB_RS02210	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPKB_RS02220	COG0833	amino acid
HPKB_RS02225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPKB_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
HPKB_RS02255	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPKB_RS02275	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HPKB_RS02310	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPKB_RS02310	COG0475	glutathione-regulated potassium exporter activity
HPKB_RS02340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPKB_RS02360	COG1217	gtp-binding protein TYPA
HPKB_RS02425	COG0753	catalase activity
HPKB_RS02440	COG2824	Alkylphosphonate utilization operon protein PhnA
HPKB_RS02445	COG2134	cdp-diacylglycerol pyrophosphatase
HPKB_RS02450	COG1749	Flagellar hook protein flgE
HPKB_RS02455	COG0375	protein maturation
HPKB_RS02470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPKB_RS02475	COG0756	dUTP diphosphatase activity
HPKB_RS02500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPKB_RS02505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPKB_RS02535	COG0671	phosphoesterase, PA-phosphatase related
HPKB_RS02560	COG0351	phosphomethylpyrimidine kinase
HPKB_RS02575	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPKB_RS02580	COG1086	Polysaccharide biosynthesis protein
HPKB_RS02610	COG0776	regulation of translation
HPKB_RS02630	COG0237	dephospho-CoA kinase activity
HPKB_RS02640	COG0516	GMP reductase activity
HPKB_RS02640	COG0517	IMP dehydrogenase activity
HPKB_RS02650	COG0724	RNA recognition motif
HPKB_RS02660	COG0492	ferredoxin-NADP+ reductase activity
HPKB_RS02665	COG3118	belongs to the thioredoxin family
HPKB_RS02675	COG0460	homoserine dehydrogenase
HPKB_RS02695	COG0517	IMP dehydrogenase activity
HPKB_RS02695	COG1125	glycine betaine transport
HPKB_RS02700	COG1732	Glycine betaine
HPKB_RS02720	COG1360	Flagellar Motor Protein
HPKB_RS02725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPKB_RS02730	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPKB_RS02735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPKB_RS02755	COG1580	Controls the rotational direction of flagella during chemotaxis
HPKB_RS02760	COG0736	holo-[acyl-carrier-protein] synthase activity
HPKB_RS02780	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPKB_RS02780	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPKB_RS02800	COG0314	molybdopterin synthase activity
HPKB_RS02805	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPKB_RS02840	COG0606	chelatase, subunit chli
HPKB_RS02845	COG2217	Heavy metal translocating P-type atpase
HPKB_RS02880	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPKB_RS02925	COG1758	RNA polymerase activity
HPKB_RS02930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPKB_RS02935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPKB_RS02940	COG0126	phosphoglycerate kinase activity
HPKB_RS02945	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPKB_RS02955	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPKB_RS02980	COG0552	protein localization to endoplasmic reticulum
HPKB_RS03000	COG0534	Mate efflux family protein
HPKB_RS03005	COG2056	Na+-H+ antiporter family
HPKB_RS03035	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPKB_RS03055	COG2884	Cell division ATP-binding protein ftsE
HPKB_RS03060	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPKB_RS03070	COG0564	pseudouridine synthase activity
HPKB_RS03075	COG1162	GTPase activity
HPKB_RS03085	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPKB_RS03095	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPKB_RS03110	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPKB_RS03115	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPKB_RS03120	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPKB_RS03160	COG0037	tRNA processing
HPKB_RS03165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPKB_RS03185	COG0252	asparaginase activity
HPKB_RS03190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPKB_RS03215	COG1279	arginine transmembrane transporter activity
HPKB_RS03220	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPKB_RS03230	COG1137	ATPase activity
HPKB_RS03235	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPKB_RS03250	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HPKB_RS03270	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPKB_RS03280	COG2204	response regulator
HPKB_RS03290	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPKB_RS03295	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPKB_RS03310	COG4647	ligase activity
HPKB_RS03315	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HPKB_RS03320	COG0145	ligase activity
HPKB_RS03330	COG2031	fatty acid transporter
HPKB_RS03335	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPKB_RS03340	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPKB_RS03345	COG0183	Belongs to the thiolase family
HPKB_RS03370	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HPKB_RS03380	COG1338	Plays a role in the flagellum-specific transport system
HPKB_RS03405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPKB_RS03415	COG0730	response to heat
HPKB_RS03425	COG4974	Belongs to the 'phage' integrase family
HPKB_RS03460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPKB_RS03470	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPKB_RS03475	COG0571	ribonuclease III activity
HPKB_RS03505	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HPKB_RS03510	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPKB_RS03515	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HPKB_RS03520	COG1528	Iron-storage protein
HPKB_RS03525	COG0560	Phosphoserine phosphatase
HPKB_RS03545	COG1027	Aspartate ammonia-lyase
HPKB_RS03570	COG0762	integral membrane protein
HPKB_RS03580	COG0778	Nitroreductase
HPKB_RS03585	COG0617	tRNA 3'-terminal CCA addition
HPKB_RS03610	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HPKB_RS03615	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HPKB_RS03620	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HPKB_RS03625	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HPKB_RS03630	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HPKB_RS03635	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPKB_RS03650	COG2171	N-acyltransferase activity
HPKB_RS03660	COG0436	Aminotransferase
HPKB_RS03675	COG1193	negative regulation of DNA recombination
HPKB_RS03680	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPKB_RS03710	COG0784	Response regulator, receiver
HPKB_RS03710	COG0835	chemotaxis
HPKB_RS03725	COG1131	(ABC) transporter
HPKB_RS03735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPKB_RS03775	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPKB_RS03785	COG0840	transmembrane signaling receptor activity
HPKB_RS03790	COG0156	8-amino-7-oxononanoate synthase activity
HPKB_RS03795	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPKB_RS03825	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPKB_RS03830	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPKB_RS03830	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPKB_RS03850	COG1918	ferrous iron import across plasma membrane
HPKB_RS03855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPKB_RS03860	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPKB_RS03860	COG1776	CheC inhibitor of MCP methylation
HPKB_RS03900	COG0681	Belongs to the peptidase S26 family
HPKB_RS03905	COG1994	Peptidase M50
HPKB_RS03910	COG0698	ribose 5-phosphate isomerase
HPKB_RS03935	COG0012	GTP binding
HPKB_RS03945	COG0628	permease
HPKB_RS03950	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPKB_RS03975	COG1028	Short-chain dehydrogenase reductase Sdr
HPKB_RS03985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPKB_RS04010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPKB_RS04015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPKB_RS04025	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPKB_RS04040	COG1842	Phage shock protein A
HPKB_RS04060	COG3451	type IV secretory pathway VirB4
HPKB_RS04205	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPKB_RS04215	COG0359	binds to the 23S rRNA
HPKB_RS04220	COG3586	endonuclease activity
HPKB_RS04225	COG0174	glutamine synthetase
HPKB_RS04245	COG0277	FAD linked oxidase domain protein
HPKB_RS04260	COG1196	nuclear chromosome segregation
HPKB_RS04260	COG0741	lytic transglycosylase activity
HPKB_RS04260	COG0739	heme binding
HPKB_RS04275	COG0187	DNA topoisomerase II activity
HPKB_RS04280	COG0592	DNA-directed DNA polymerase activity
HPKB_RS04290	COG0733	neurotransmitter:sodium symporter activity
HPKB_RS04295	COG0733	neurotransmitter:sodium symporter activity
HPKB_RS04300	COG0824	Thioesterase
HPKB_RS04310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPKB_RS04365	COG0728	peptidoglycan biosynthetic process
HPKB_RS04380	COG1120	ATPase activity
HPKB_RS04385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPKB_RS04390	COG0300	oxidoreductase activity
HPKB_RS04395	COG1607	acyl-coa hydrolase
HPKB_RS04400	COG3041	Addiction module toxin RelE StbE family
HPKB_RS04435	COG0409	Hydrogenase expression formation protein
HPKB_RS04440	COG0298	carbon dioxide binding
HPKB_RS04445	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HPKB_RS04475	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HPKB_RS04525	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPKB_RS04530	COG0670	Belongs to the BI1 family
HPKB_RS04535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPKB_RS04550	COG1942	4-Oxalocrotonate Tautomerase
HPKB_RS04575	COG0142	geranyltranstransferase activity
HPKB_RS04590	COG0720	synthase
HPKB_RS04595	COG0602	queuosine metabolic process
HPKB_RS04610	COG0477	Major facilitator Superfamily
HPKB_RS04625	COG0765	amino acid transport
HPKB_RS04630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPKB_RS04640	COG1115	amino acid carrier protein
HPKB_RS04645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPKB_RS04680	COG1757	Na H antiporter
HPKB_RS04700	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPKB_RS04710	COG1546	Belongs to the CinA family
HPKB_RS04710	COG1058	Belongs to the CinA family
HPKB_RS04735	COG1519	Transferase
HPKB_RS04735	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPKB_RS04745	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPKB_RS04775	COG3309	Virulence-associated protein D
HPKB_RS04810	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPKB_RS04815	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPKB_RS04820	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPKB_RS04830	COG0849	cell division
HPKB_RS04835	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPKB_RS04840	COG0668	transmembrane transport
HPKB_RS04880	COG1166	arginine decarboxylase activity
HPKB_RS04895	COG0500	methyltransferase
HPKB_RS04905	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPKB_RS04905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPKB_RS04910	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPKB_RS04915	COG0668	transmembrane transport
HPKB_RS04960	COG0243	molybdopterin cofactor binding
HPKB_RS04975	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPKB_RS04980	COG0537	adenosine 5'-monophosphoramidase activity
HPKB_RS04990	COG0072	phenylalanine-tRNA ligase activity
HPKB_RS04990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPKB_RS05005	COG1185	polyribonucleotide nucleotidyltransferase activity
HPKB_RS05005	COG0539	negative regulation of cytoplasmic translation
HPKB_RS05015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPKB_RS05020	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPKB_RS05025	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPKB_RS05035	COG0835	chemotaxis
HPKB_RS05035	COG0784	Response regulator, receiver
HPKB_RS05040	COG0643	Histidine kinase
HPKB_RS05040	COG0784	Response regulator, receiver
HPKB_RS05040	COG2198	Histidine kinase
HPKB_RS05045	COG0835	chemotaxis
HPKB_RS05050	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HPKB_RS05065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPKB_RS05090	COG0501	Belongs to the peptidase M48B family
HPKB_RS05095	COG2890	protein-(glutamine-N5) methyltransferase activity
HPKB_RS05100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPKB_RS05110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPKB_RS05110	COG1333	cytochrome c biogenesis protein
HPKB_RS05130	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPKB_RS05145	COG0511	ligase activity, forming carbon-carbon bonds
HPKB_RS05150	COG0439	Biotin carboxylase
HPKB_RS05170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPKB_RS05180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPKB_RS05185	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPKB_RS05195	COG0101	tRNA pseudouridine synthase activity
HPKB_RS05220	COG4221	oxidoreductase activity
HPKB_RS05225	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPKB_RS05230	COG0800	Aldolase
HPKB_RS05235	COG0129	dihydroxy-acid dehydratase activity
HPKB_RS05240	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPKB_RS05245	COG0363	glucosamine-6-phosphate deaminase activity
HPKB_RS05255	COG1064	alcohol dehydrogenase
HPKB_RS05280	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPKB_RS05290	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPKB_RS05295	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPKB_RS05300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPKB_RS05330	COG0405	Gamma-glutamyltransferase
HPKB_RS05335	COG1749	Flagellar hook protein flgE
HPKB_RS05360	COG1047	Peptidyl-prolyl cis-trans
HPKB_RS05370	COG2885	chlorophyll binding
HPKB_RS05375	COG0823	Involved in the tonB-independent uptake of proteins
HPKB_RS05385	COG0848	biopolymer transport protein
HPKB_RS05390	COG0811	peptide transport
HPKB_RS05400	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPKB_RS05430	COG1475	DNA binding
HPKB_RS05435	COG1192	Involved in chromosome partitioning
HPKB_RS05440	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HPKB_RS05440	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HPKB_RS05445	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPKB_RS05485	COG0336	Belongs to the RNA methyltransferase TrmD family
HPKB_RS05505	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPKB_RS05510	COG0525	valine-tRNA ligase activity
HPKB_RS05520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPKB_RS05535	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPKB_RS05540	COG2184	nucleotidyltransferase activity
HPKB_RS05550	COG0716	FMN binding
HPKB_RS05595	COG0765	amino acid transport
HPKB_RS05600	COG1126	abc transporter atp-binding protein
HPKB_RS05615	COG0738	Major facilitator superfamily
HPKB_RS05620	COG2252	PERMEase
HPKB_RS05640	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPKB_RS05650	COG2814	Major facilitator Superfamily
HPKB_RS05655	COG0037	tRNA processing
HPKB_RS05660	COG0475	glutathione-regulated potassium exporter activity
HPKB_RS05660	COG0569	domain protein
HPKB_RS05670	COG2814	Major facilitator Superfamily
HPKB_RS05685	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPKB_RS05695	COG0859	PFAM glycosyl transferase family 9
HPKB_RS05745	COG0250	Participates in transcription elongation, termination and antitermination
HPKB_RS05790	COG1132	(ABC) transporter
HPKB_RS05810	COG1045	serine acetyltransferase
HPKB_RS05830	COG1185	polyribonucleotide nucleotidyltransferase activity
HPKB_RS05850	COG0151	Belongs to the GarS family
HPKB_RS05860	COG1131	(ABC) transporter
HPKB_RS05865	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPKB_RS05890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPKB_RS05895	COG2863	cytochrome
HPKB_RS05905	COG0527	aspartate kinase activity
HPKB_RS05920	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPKB_RS05930	COG0697	spore germination
HPKB_RS05945	COG0505	Belongs to the CarA family
HPKB_RS05960	COG0424	maF-like protein
HPKB_RS05985	COG0629	single-stranded DNA binding
HPKB_RS05995	COG1466	dna polymerase III delta subunit
HPKB_RS06000	COG0557	exoribonuclease II activity
HPKB_RS06015	COG4174	ABC transporter (Permease)
HPKB_RS06020	COG4166	transmembrane transport
HPKB_RS06025	COG0180	Tryptophanyl-tRNA synthetase
HPKB_RS06035	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPKB_RS06060	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPKB_RS06105	COG0839	Belongs to the complex I subunit 6 family
HPKB_RS06110	COG0713	ATP synthesis coupled electron transport
HPKB_RS06115	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPKB_RS06125	COG1007	ATP synthesis coupled electron transport
HPKB_RS06150	COG0133	tryptophan synthase activity
HPKB_RS06155	COG0134	indole-3-glycerol-phosphate synthase activity
HPKB_RS06155	COG0135	phosphoribosylanthranilate isomerase activity
HPKB_RS06165	COG0512	Glutamine amidotransferase of anthranilate synthase
HPKB_RS06170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPKB_RS06175	COG0859	PFAM glycosyl transferase family 9
HPKB_RS06185	COG2353	YceI-like domain
HPKB_RS06190	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HPKB_RS06210	COG0202	RNA polymerase activity
HPKB_RS06215	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPKB_RS06235	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPKB_RS06240	COG0024	Methionine aminopeptidase
HPKB_RS06280	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPKB_RS06300	COG0255	Belongs to the universal ribosomal protein uL29 family
HPKB_RS06315	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPKB_RS06340	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPKB_RS06370	COG0114	fumarate hydratase activity
HPKB_RS06390	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPKB_RS06395	COG1687	branched-chain amino acid
HPKB_RS06400	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HPKB_RS06405	COG0484	heat shock protein binding
HPKB_RS06435	COG0811	peptide transport
HPKB_RS06440	COG0848	biopolymer transport protein
HPKB_RS06445	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPKB_RS06455	COG2957	Belongs to the agmatine deiminase family
HPKB_RS06460	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HPKB_RS06480	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HPKB_RS06530	COG0542	response to heat
HPKB_RS06535	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPKB_RS06540	COG0589	response to stress
HPKB_RS06560	COG0538	isocitrate dehydrogenase activity
HPKB_RS06565	COG0372	Belongs to the citrate synthase family
HPKB_RS06590	COG1295	ribonuclease BN
HPKB_RS06635	COG0799	negative regulation of ribosome biogenesis
HPKB_RS06660	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPKB_RS06665	COG1987	bacterial-type flagellum assembly
HPKB_RS06670	COG1157	protein secretion by the type III secretion system
HPKB_RS06675	COG4962	Type ii secretion system protein e
HPKB_RS06685	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPKB_RS06705	COG0517	IMP dehydrogenase activity
HPKB_RS06705	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPKB_RS06710	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPKB_RS06735	COG0788	formyltetrahydrofolate deformylase activity
HPKB_RS06785	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPKB_RS06805	COG0811	peptide transport
HPKB_RS06810	COG0848	biopolymer transport protein
HPKB_RS06830	COG0706	membrane insertase activity
HPKB_RS06870	COG3118	belongs to the thioredoxin family
HPKB_RS06875	COG1187	pseudouridine synthase activity
HPKB_RS06905	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPKB_RS06910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPKB_RS06920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPKB_RS06930	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPKB_RS06930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPKB_RS06965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPKB_RS06970	COG0163	prenyltransferase activity
HPKB_RS07005	COG2226	methyltransferase
HPKB_RS07010	COG1981	membrane
HPKB_RS07015	COG1739	Uncharacterized protein family UPF0029
HPKB_RS07030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPKB_RS07040	COG1253	flavin adenine dinucleotide binding
HPKB_RS07045	COG0306	phosphate transporter
HPKB_RS07050	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HPKB_RS07060	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPKB_RS07110	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HPKB_RS07120	COG0786	glutamate:sodium symporter activity
HPKB_RS07130	COG0348	domain, Protein
HPKB_RS07135	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPKB_RS07155	COG1921	L-seryl-tRNASec selenium transferase activity
HPKB_RS07160	COG0195	Participates in both transcription termination and antitermination
HPKB_RS07190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPKB_RS07205	COG0708	Exodeoxyribonuclease III
HPKB_RS07240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPKB_RS07245	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HPKB_RS07250	COG0732	type I restriction modification DNA specificity domain
HPKB_RS07265	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HPKB_RS07280	COG0010	Belongs to the arginase family
HPKB_RS07285	COG0833	amino acid
HPKB_RS07290	COG0686	Belongs to the AlaDH PNT family
HPKB_RS07310	COG0497	DNA recombination
HPKB_RS07345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPKB_RS07385	COG1074	ATP-dependent DNA helicase activity
HPKB_RS07395	COG1862	Preprotein translocase
HPKB_RS07400	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPKB_RS07405	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPKB_RS07415	COG0495	leucyl-tRNA aminoacylation
HPKB_RS07425	COG0285	dihydrofolate synthase activity
HPKB_RS07435	COG0739	heme binding
HPKB_RS07445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPKB_RS07450	COG0723	plastoquinol--plastocyanin reductase activity
HPKB_RS07475	COG0768	penicillin binding
HPKB_RS07485	COG1558	bacterial-type flagellum-dependent cell motility
HPKB_RS07490	COG1815	bacterial-type flagellum-dependent cell motility
HPKB_RS07495	COG0772	Belongs to the SEDS family
HPKB_RS07510	COG0450	alkyl hydroperoxide reductase
HPKB_RS07520	COG0768	penicillin binding
HPKB_RS07545	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HPKB_RS07550	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPKB_RS07555	COG0741	lytic transglycosylase activity
HPKB_RS07555	COG1388	LysM domain
HPKB_RS07560	COG0084	hydrolase, TatD family'
HPKB_RS07565	COG0307	riboflavin synthase, alpha
HPKB_RS07580	COG2011	ABC-type metal ion transport system permease component
HPKB_RS07590	COG0671	phosphoesterase, PA-phosphatase related
HPKB_RS07595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPKB_RS07615	COG4786	Flagellar basal body rod
HPKB_RS07625	COG4735	regulation of single-species biofilm formation
HPKB_RS07655	COG0280	phosphate acetyltransferase