locus-tag	class	description
HGI45_RS00015	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HGI45_RS00020	COG0288	reversible hydration of carbon dioxide
HGI45_RS00025	COG0284	orotidine-5'-phosphate decarboxylase activity
HGI45_RS00075	COG0358	DNA primase activity
HGI45_RS00080	COG0482	sulfurtransferase activity
HGI45_RS00115	COG0784	Response regulator, receiver
HGI45_RS00115	COG0835	chemotaxis
HGI45_RS00125	COG0671	phosphoesterase, PA-phosphatase related
HGI45_RS00130	COG2194	sulfuric ester hydrolase activity
HGI45_RS00140	COG0372	Belongs to the citrate synthase family
HGI45_RS00145	COG0538	isocitrate dehydrogenase activity
HGI45_RS00155	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HGI45_RS00165	COG0589	response to stress
HGI45_RS00170	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HGI45_RS00175	COG0542	response to heat
HGI45_RS00225	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HGI45_RS00250	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HGI45_RS00255	COG2957	Belongs to the agmatine deiminase family
HGI45_RS00295	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HGI45_RS00365	COG0830	nickel cation binding
HGI45_RS00370	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HGI45_RS00380	COG0804	urea catabolic process
HGI45_RS00385	COG0832	Belongs to the urease beta subunit family
HGI45_RS00385	COG0831	urea catabolic process
HGI45_RS00400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HGI45_RS00410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HGI45_RS00435	COG0840	transmembrane signaling receptor activity
HGI45_RS00465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HGI45_RS00470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HGI45_RS00475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HGI45_RS00505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGI45_RS00515	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HGI45_RS00520	COG0840	transmembrane signaling receptor activity
HGI45_RS00525	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HGI45_RS00545	COG0737	Belongs to the 5'-nucleotidase family
HGI45_RS00555	COG0626	cystathionine gamma-synthase activity
HGI45_RS00560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HGI45_RS00580	COG1420	regulation of RNA biosynthetic process
HGI45_RS00600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HGI45_RS00605	COG0551	DNA topoisomerase type I activity
HGI45_RS00605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HGI45_RS00610	COG0731	radical SAM domain protein
HGI45_RS00620	COG0574	Belongs to the PEP-utilizing enzyme family
HGI45_RS00620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HGI45_RS00630	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HGI45_RS00660	COG1760	l-serine dehydratase
HGI45_RS00665	COG0814	amino acid
HGI45_RS00670	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HGI45_RS00675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HGI45_RS00685	COG1139	Iron-sulfur cluster binding protein
HGI45_RS00690	COG0247	lactate metabolic process
HGI45_RS00695	COG1620	l-lactate permease
HGI45_RS00700	COG1620	l-lactate permease
HGI45_RS00705	COG1194	a g-specific adenine glycosylase
HGI45_RS00710	COG0471	metal ion transport
HGI45_RS00715	COG3278	Belongs to the heme-copper respiratory oxidase family
HGI45_RS00780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HGI45_RS00795	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HGI45_RS00800	COG0217	transcriptional regulatory protein
HGI45_RS00805	COG0113	porphobilinogen synthase activity
HGI45_RS00810	COG0642	Histidine kinase
HGI45_RS00815	COG0745	RESPONSE REGULATOR receiver
HGI45_RS00830	COG0826	peptidase U32
HGI45_RS00845	COG0303	'Molybdopterin
HGI45_RS00860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HGI45_RS00865	COG0191	fructose-bisphosphate aldolase activity
HGI45_RS00870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HGI45_RS00895	COG2089	acid synthase
HGI45_RS00900	COG1136	(ABC) transporter
HGI45_RS00905	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HGI45_RS00945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGI45_RS00950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HGI45_RS00955	COG1053	succinate dehydrogenase
HGI45_RS00965	COG0149	triose-phosphate isomerase activity
HGI45_RS00970	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HGI45_RS00980	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HGI45_RS00985	COG0105	UTP biosynthetic process
HGI45_RS01000	COG0416	fatty acid biosynthetic process
HGI45_RS01040	COG0326	Molecular chaperone. Has ATPase activity
HGI45_RS01045	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HGI45_RS01060	COG0471	metal ion transport
HGI45_RS01065	COG0575	Belongs to the CDS family
HGI45_RS01070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HGI45_RS01080	COG1881	PFAM PEBP family protein
HGI45_RS01090	COG1104	cysteine desulfurase activity
HGI45_RS01105	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HGI45_RS01110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGI45_RS01110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGI45_RS01115	COG0730	response to heat
HGI45_RS01125	COG0659	secondary active sulfate transmembrane transporter activity
HGI45_RS01155	COG0754	glutathionylspermidine amidase activity
HGI45_RS01165	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HGI45_RS01175	COG0181	hydroxymethylbilane synthase activity
HGI45_RS01205	COG0783	Belongs to the Dps family
HGI45_RS01210	COG0642	Histidine kinase
HGI45_RS01215	COG3951	Flagellar rod assembly protein muramidase FlgJ
HGI45_RS01240	COG4172	Belongs to the ABC transporter superfamily
HGI45_RS01245	COG4239	(ABC) transporter, permease
HGI45_RS01280	COG0750	zinc metalloprotease
HGI45_RS01285	COG1570	exodeoxyribonuclease VII activity
HGI45_RS01310	COG0542	response to heat
HGI45_RS01315	COG0785	Cytochrome C biogenesis protein
HGI45_RS01320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HGI45_RS01325	COG0402	S-adenosylhomocysteine deaminase activity
HGI45_RS01335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HGI45_RS01360	COG0727	PFAM Uncharacterised protein family (UPF0153)
HGI45_RS01370	COG0134	indole-3-glycerol-phosphate synthase activity
HGI45_RS01380	COG0248	Ppx GppA phosphatase
HGI45_RS01385	COG0859	PFAM glycosyl transferase family 9
HGI45_RS01405	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HGI45_RS01415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HGI45_RS01420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HGI45_RS01440	COG0019	diaminopimelate decarboxylase activity
HGI45_RS01455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HGI45_RS01475	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HGI45_RS01480	COG0747	negative chemotaxis
HGI45_RS01485	COG0601	transmembrane transport
HGI45_RS01490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGI45_RS01495	COG0444	Belongs to the ABC transporter superfamily
HGI45_RS01500	COG4608	Belongs to the ABC transporter superfamily
HGI45_RS01505	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HGI45_RS01520	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HGI45_RS01535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HGI45_RS01540	COG0726	polysaccharide deacetylase
HGI45_RS01550	COG0523	cobalamin synthesis protein
HGI45_RS01565	COG3842	ATPase activity
HGI45_RS01570	COG0748	coenzyme F420 binding
HGI45_RS01605	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HGI45_RS01610	COG3980	spore coat polysaccharide biosynthesis protein
HGI45_RS01615	COG3980	spore coat polysaccharide biosynthesis protein
HGI45_RS01620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HGI45_RS01625	COG1663	tetraacyldisaccharide 4'-kinase activity
HGI45_RS01630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HGI45_RS01645	COG2894	cell division
HGI45_RS01655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HGI45_RS01655	COG0758	DNA mediated transformation
HGI45_RS01660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HGI45_RS01665	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HGI45_RS01680	COG0564	pseudouridine synthase activity
HGI45_RS01685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HGI45_RS01685	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HGI45_RS01690	COG0504	CTP synthase activity
HGI45_RS01700	COG1766	The M ring may be actively involved in energy transduction
HGI45_RS01705	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGI45_RS01715	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HGI45_RS01740	COG4786	Flagellar basal body rod
HGI45_RS01745	COG0477	Major facilitator Superfamily
HGI45_RS01750	COG1674	ftsk spoiiie
HGI45_RS01760	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HGI45_RS01765	COG0196	riboflavin kinase activity
HGI45_RS01770	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HGI45_RS01780	COG0540	Belongs to the ATCase OTCase family
HGI45_RS01790	COG1132	(ABC) transporter
HGI45_RS01805	COG1106	Psort location Cytoplasmic, score
HGI45_RS01815	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HGI45_RS01830	COG2608	mercury ion transmembrane transporter activity
HGI45_RS01840	COG1183	phosphatidylcholine synthase activity
HGI45_RS01850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HGI45_RS01855	COG2264	protein methyltransferase activity
HGI45_RS01860	COG0745	RESPONSE REGULATOR receiver
HGI45_RS01885	COG0357	Ribosomal RNA small subunit methyltransferase G
HGI45_RS01890	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HGI45_RS01895	COG0805	protein transport
HGI45_RS01900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HGI45_RS01910	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HGI45_RS01935	COG0850	regulation of cytokinetic process
HGI45_RS01950	COG0083	homoserine kinase activity
HGI45_RS01985	COG0745	RESPONSE REGULATOR receiver
HGI45_RS01990	COG2404	hydrolase activity, acting on ester bonds
HGI45_RS01995	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HGI45_RS02000	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HGI45_RS02015	COG0006	proline dipeptidase activity
HGI45_RS02020	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HGI45_RS02025	COG1419	protein localization to endoplasmic reticulum
HGI45_RS02030	COG0455	bacterial-type flagellum organization
HGI45_RS02045	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGI45_RS02050	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGI45_RS02050	COG1776	CheC inhibitor of MCP methylation
HGI45_RS02065	COG0735	belongs to the Fur family
HGI45_RS02070	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HGI45_RS02070	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HGI45_RS02075	COG0789	Transcriptional regulator
HGI45_RS02080	COG0484	heat shock protein binding
HGI45_RS02095	COG0745	RESPONSE REGULATOR receiver
HGI45_RS02110	COG0833	amino acid
HGI45_RS02115	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HGI45_RS02125	COG1028	Short-chain dehydrogenase reductase Sdr
HGI45_RS02130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HGI45_RS02140	COG0167	dihydroorotate dehydrogenase activity
HGI45_RS02145	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HGI45_RS02245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HGI45_RS02265	COG1217	gtp-binding protein TYPA
HGI45_RS02345	COG0824	Thioesterase
HGI45_RS02350	COG0733	neurotransmitter:sodium symporter activity
HGI45_RS02355	COG0733	neurotransmitter:sodium symporter activity
HGI45_RS02365	COG0592	DNA-directed DNA polymerase activity
HGI45_RS02370	COG0187	DNA topoisomerase II activity
HGI45_RS02385	COG0739	heme binding
HGI45_RS02400	COG0277	FAD linked oxidase domain protein
HGI45_RS02415	COG0174	glutamine synthetase
HGI45_RS02430	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HGI45_RS02570	COG3451	type IV secretory pathway VirB4
HGI45_RS02590	COG1842	Phage shock protein A
HGI45_RS02610	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HGI45_RS02620	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HGI45_RS02650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HGI45_RS02660	COG1028	Short-chain dehydrogenase reductase Sdr
HGI45_RS02690	COG0628	permease
HGI45_RS02700	COG0012	GTP binding
HGI45_RS02725	COG0698	ribose 5-phosphate isomerase
HGI45_RS02730	COG1994	Peptidase M50
HGI45_RS02735	COG0681	Belongs to the peptidase S26 family
HGI45_RS02740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HGI45_RS02760	COG0418	dihydroorotase activity
HGI45_RS02775	COG1776	CheC inhibitor of MCP methylation
HGI45_RS02775	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGI45_RS02780	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HGI45_RS02785	COG1918	ferrous iron import across plasma membrane
HGI45_RS02805	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HGI45_RS02805	COG0674	pyruvate-flavodoxin oxidoreductase activity
HGI45_RS02810	COG1013	pyruvate-flavodoxin oxidoreductase activity
HGI45_RS02845	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HGI45_RS02850	COG0156	8-amino-7-oxononanoate synthase activity
HGI45_RS02855	COG0840	transmembrane signaling receptor activity
HGI45_RS02870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HGI45_RS02910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HGI45_RS02930	COG4974	Belongs to the 'phage' integrase family
HGI45_RS02950	COG3550	peptidyl-serine autophosphorylation
HGI45_RS02990	COG1192	Involved in chromosome partitioning
HGI45_RS03015	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HGI45_RS03040	COG4962	Type ii secretion system protein e
HGI45_RS03090	COG1607	acyl-coa hydrolase
HGI45_RS03095	COG0300	oxidoreductase activity
HGI45_RS03100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGI45_RS03105	COG1120	ATPase activity
HGI45_RS03120	COG0728	peptidoglycan biosynthetic process
HGI45_RS03130	COG0632	four-way junction helicase activity
HGI45_RS03145	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HGI45_RS03155	COG0753	catalase activity
HGI45_RS03170	COG2824	Alkylphosphonate utilization operon protein PhnA
HGI45_RS03180	COG1749	Flagellar hook protein flgE
HGI45_RS03185	COG0375	protein maturation
HGI45_RS03195	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HGI45_RS03200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HGI45_RS03205	COG0756	dUTP diphosphatase activity
HGI45_RS03220	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HGI45_RS03230	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HGI45_RS03235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGI45_RS03250	COG0516	GMP reductase activity
HGI45_RS03255	COG0488	(ABC) transporter
HGI45_RS03265	COG0671	phosphoesterase, PA-phosphatase related
HGI45_RS03290	COG0351	phosphomethylpyrimidine kinase
HGI45_RS03295	COG0352	thiamine-phosphate diphosphorylase activity
HGI45_RS03305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HGI45_RS03310	COG1086	Polysaccharide biosynthesis protein
HGI45_RS03335	COG0776	regulation of translation
HGI45_RS03340	COG1160	GTP binding
HGI45_RS03350	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HGI45_RS03355	COG0237	dephospho-CoA kinase activity
HGI45_RS03360	COG0154	amidase activity
HGI45_RS03365	COG0516	GMP reductase activity
HGI45_RS03365	COG0517	IMP dehydrogenase activity
HGI45_RS03375	COG0724	RNA recognition motif
HGI45_RS03385	COG0492	ferredoxin-NADP+ reductase activity
HGI45_RS03390	COG3118	belongs to the thioredoxin family
HGI45_RS03400	COG0460	homoserine dehydrogenase
HGI45_RS03420	COG0517	IMP dehydrogenase activity
HGI45_RS03420	COG1125	glycine betaine transport
HGI45_RS03425	COG1732	Glycine betaine
HGI45_RS03435	COG1360	Flagellar Motor Protein
HGI45_RS03440	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HGI45_RS03445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HGI45_RS03495	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HGI45_RS03495	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HGI45_RS03515	COG0314	molybdopterin synthase activity
HGI45_RS03520	COG0521	Mo-molybdopterin cofactor biosynthetic process
HGI45_RS03525	COG0315	cyclic pyranopterin monophosphate synthase activity
HGI45_RS03555	COG0606	chelatase, subunit chli
HGI45_RS03560	COG2217	Heavy metal translocating P-type atpase
HGI45_RS03615	COG1049	propionate catabolic process, 2-methylcitrate cycle
HGI45_RS03625	COG0528	UMP kinase activity
HGI45_RS03630	COG1758	RNA polymerase activity
HGI45_RS03640	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HGI45_RS03650	COG0860	N-Acetylmuramoyl-L-alanine amidase
HGI45_RS03660	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HGI45_RS03695	COG0552	protein localization to endoplasmic reticulum
HGI45_RS03715	COG0534	Mate efflux family protein
HGI45_RS03720	COG2056	Na+-H+ antiporter family
HGI45_RS03735	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HGI45_RS03750	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HGI45_RS03770	COG2884	Cell division ATP-binding protein ftsE
HGI45_RS03775	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HGI45_RS03785	COG0564	pseudouridine synthase activity
HGI45_RS03790	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HGI45_RS03800	COG0772	Belongs to the SEDS family
HGI45_RS03810	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HGI45_RS03820	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HGI45_RS03830	COG1181	Belongs to the D-alanine--D-alanine ligase family
HGI45_RS03835	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HGI45_RS03840	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HGI45_RS03845	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HGI45_RS03850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HGI45_RS03875	COG0037	tRNA processing
HGI45_RS03880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HGI45_RS03895	COG0252	asparaginase activity
HGI45_RS03900	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HGI45_RS03925	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HGI45_RS03935	COG1137	ATPase activity
HGI45_RS03940	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HGI45_RS03945	COG3177	Filamentation induced by cAMP protein fic
HGI45_RS03960	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HGI45_RS03980	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HGI45_RS03985	COG2204	response regulator
HGI45_RS03995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HGI45_RS04000	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HGI45_RS04010	COG0183	Belongs to the thiolase family
HGI45_RS04015	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HGI45_RS04020	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HGI45_RS04025	COG2031	fatty acid transporter
HGI45_RS04035	COG0145	ligase activity
HGI45_RS04040	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HGI45_RS04045	COG4647	ligase activity
HGI45_RS04065	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HGI45_RS04075	COG1338	Plays a role in the flagellum-specific transport system
HGI45_RS04080	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HGI45_RS04095	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGI45_RS04105	COG0730	response to heat
HGI45_RS04115	COG4974	Belongs to the 'phage' integrase family
HGI45_RS04140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HGI45_RS04160	COG0328	RNA-DNA hybrid ribonuclease activity
HGI45_RS04175	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HGI45_RS04185	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HGI45_RS04190	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGI45_RS04195	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HGI45_RS04200	COG1528	Iron-storage protein
HGI45_RS04205	COG0560	Phosphoserine phosphatase
HGI45_RS04220	COG1027	Aspartate ammonia-lyase
HGI45_RS04255	COG0778	Nitroreductase
HGI45_RS04260	COG2084	Dehydrogenase
HGI45_RS04270	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HGI45_RS04290	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HGI45_RS04295	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HGI45_RS04300	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HGI45_RS04305	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HGI45_RS04310	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HGI45_RS04315	COG2249	NAD(P)H dehydrogenase (quinone) activity
HGI45_RS04330	COG2171	N-acyltransferase activity
HGI45_RS04340	COG0436	Aminotransferase
HGI45_RS04345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HGI45_RS04355	COG1193	negative regulation of DNA recombination
HGI45_RS04360	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HGI45_RS04370	COG3306	glycosyltransferase involved in LPS biosynthesis
HGI45_RS04385	COG0784	Response regulator, receiver
HGI45_RS04385	COG0835	chemotaxis
HGI45_RS04390	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HGI45_RS04440	COG3041	Addiction module toxin RelE StbE family
HGI45_RS04470	COG0409	Hydrogenase expression formation protein
HGI45_RS04475	COG0298	carbon dioxide binding
HGI45_RS04480	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HGI45_RS04495	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HGI45_RS04500	COG0280	phosphate acetyltransferase
HGI45_RS04505	COG0280	phosphate acetyltransferase
HGI45_RS04515	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HGI45_RS04520	COG1749	Flagellar hook protein flgE
HGI45_RS04520	COG1749	Flagellar hook protein flgE
HGI45_RS04565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HGI45_RS04570	COG0670	Belongs to the BI1 family
HGI45_RS04575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HGI45_RS04590	COG1942	4-Oxalocrotonate Tautomerase
HGI45_RS04600	COG0585	pseudouridine synthase activity
HGI45_RS04605	COG0501	Belongs to the peptidase M48B family
HGI45_RS04615	COG0142	geranyltranstransferase activity
HGI45_RS04630	COG0720	synthase
HGI45_RS04635	COG0602	queuosine metabolic process
HGI45_RS04645	COG0358	DNA primase activity
HGI45_RS04675	COG0582	viral genome integration into host DNA
HGI45_RS04695	COG0477	Major facilitator Superfamily
HGI45_RS04710	COG0765	amino acid transport
HGI45_RS04715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGI45_RS04720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HGI45_RS04725	COG1115	amino acid carrier protein
HGI45_RS04730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGI45_RS04735	COG0251	oxidation-reduction process
HGI45_RS04775	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HGI45_RS04780	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HGI45_RS04790	COG1546	Belongs to the CinA family
HGI45_RS04790	COG1058	Belongs to the CinA family
HGI45_RS04800	COG0778	Nitroreductase
HGI45_RS04805	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HGI45_RS04810	COG0564	pseudouridine synthase activity
HGI45_RS04815	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HGI45_RS04815	COG1519	Transferase
HGI45_RS04825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HGI45_RS04830	COG0752	glycyl-tRNA synthetase alpha subunit
HGI45_RS04835	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HGI45_RS04880	COG0751	glycine-tRNA ligase activity
HGI45_RS04890	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HGI45_RS04895	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HGI45_RS04900	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HGI45_RS04905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HGI45_RS04910	COG0849	cell division
HGI45_RS04915	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HGI45_RS04925	COG0668	transmembrane transport
HGI45_RS04940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HGI45_RS04975	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HGI45_RS05025	COG1192	Involved in chromosome partitioning
HGI45_RS05115	COG1598	PFAM Uncharacterised protein family UPF0150
HGI45_RS05125	COG1166	arginine decarboxylase activity
HGI45_RS05150	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGI45_RS05150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGI45_RS05155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HGI45_RS05160	COG0668	transmembrane transport
HGI45_RS05210	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HGI45_RS05215	COG0537	adenosine 5'-monophosphoramidase activity
HGI45_RS05225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGI45_RS05225	COG0072	phenylalanine-tRNA ligase activity
HGI45_RS05240	COG1185	polyribonucleotide nucleotidyltransferase activity
HGI45_RS05240	COG0539	negative regulation of cytoplasmic translation
HGI45_RS05250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HGI45_RS05255	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HGI45_RS05260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HGI45_RS05270	COG0784	Response regulator, receiver
HGI45_RS05270	COG0835	chemotaxis
HGI45_RS05275	COG2198	Histidine kinase
HGI45_RS05275	COG0784	Response regulator, receiver
HGI45_RS05275	COG0643	Histidine kinase
HGI45_RS05280	COG0835	chemotaxis
HGI45_RS05285	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HGI45_RS05290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HGI45_RS05300	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HGI45_RS05325	COG0501	Belongs to the peptidase M48B family
HGI45_RS05330	COG2890	protein-(glutamine-N5) methyltransferase activity
HGI45_RS05335	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HGI45_RS05345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HGI45_RS05345	COG1333	cytochrome c biogenesis protein
HGI45_RS05365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HGI45_RS05380	COG0511	ligase activity, forming carbon-carbon bonds
HGI45_RS05385	COG0439	Biotin carboxylase
HGI45_RS05415	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HGI45_RS05425	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGI45_RS05430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HGI45_RS05440	COG0101	tRNA pseudouridine synthase activity
HGI45_RS05470	COG4221	oxidoreductase activity
HGI45_RS05475	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HGI45_RS05480	COG0800	Aldolase
HGI45_RS05485	COG0129	dihydroxy-acid dehydratase activity
HGI45_RS05490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HGI45_RS05495	COG0363	glucosamine-6-phosphate deaminase activity
HGI45_RS05505	COG1064	alcohol dehydrogenase
HGI45_RS05530	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HGI45_RS05540	COG0674	pyruvate-flavodoxin oxidoreductase activity
HGI45_RS05545	COG1013	pyruvate-flavodoxin oxidoreductase activity
HGI45_RS05550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HGI45_RS05560	COG0556	nucleotide-excision repair
HGI45_RS05585	COG0405	Gamma-glutamyltransferase
HGI45_RS05615	COG1047	Peptidyl-prolyl cis-trans
HGI45_RS05625	COG2885	chlorophyll binding
HGI45_RS05630	COG0823	Involved in the tonB-independent uptake of proteins
HGI45_RS05640	COG0848	biopolymer transport protein
HGI45_RS05645	COG0811	peptide transport
HGI45_RS05685	COG1475	DNA binding
HGI45_RS05690	COG1192	Involved in chromosome partitioning
HGI45_RS05740	COG0336	Belongs to the RNA methyltransferase TrmD family
HGI45_RS05745	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HGI45_RS05760	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HGI45_RS05765	COG0525	valine-tRNA ligase activity
HGI45_RS05790	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HGI45_RS05795	COG2184	nucleotidyltransferase activity
HGI45_RS05800	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HGI45_RS05805	COG0716	FMN binding
HGI45_RS05820	COG0492	ferredoxin-NADP+ reductase activity
HGI45_RS05840	COG1966	Carbon starvation protein
HGI45_RS05850	COG0765	amino acid transport
HGI45_RS05855	COG1126	abc transporter atp-binding protein
HGI45_RS05870	COG0738	Major facilitator superfamily
HGI45_RS05875	COG2252	PERMEase
HGI45_RS05895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HGI45_RS05905	COG2814	Major facilitator Superfamily
HGI45_RS05910	COG0037	tRNA processing
HGI45_RS05915	COG0475	glutathione-regulated potassium exporter activity
HGI45_RS05915	COG0569	domain protein
HGI45_RS05940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HGI45_RS05945	COG0124	histidyl-tRNA synthetase
HGI45_RS05950	COG0859	PFAM glycosyl transferase family 9
HGI45_RS05960	COG0667	Aldo Keto reductase
HGI45_RS05980	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HGI45_RS05980	COG0085	RNA polymerase activity
HGI45_RS05995	COG0081	regulation of translation
HGI45_RS06005	COG0250	Participates in transcription elongation, termination and antitermination
HGI45_RS06050	COG1132	(ABC) transporter
HGI45_RS06070	COG1045	serine acetyltransferase
HGI45_RS06085	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HGI45_RS06090	COG1185	polyribonucleotide nucleotidyltransferase activity
HGI45_RS06100	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HGI45_RS06110	COG0151	Belongs to the GarS family
HGI45_RS06115	COG1131	(ABC) transporter
HGI45_RS06120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HGI45_RS06140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HGI45_RS06145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HGI45_RS06150	COG2863	cytochrome
HGI45_RS06160	COG0527	aspartate kinase activity
HGI45_RS06175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HGI45_RS06185	COG0697	spore germination
HGI45_RS06200	COG0505	Belongs to the CarA family
HGI45_RS06225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HGI45_RS06245	COG0629	single-stranded DNA binding
HGI45_RS06255	COG1466	dna polymerase III delta subunit
HGI45_RS06260	COG0557	exoribonuclease II activity
HGI45_RS06265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HGI45_RS06275	COG4174	ABC transporter (Permease)
HGI45_RS06280	COG4166	transmembrane transport
HGI45_RS06285	COG0180	Tryptophanyl-tRNA synthetase
HGI45_RS06295	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HGI45_RS06300	COG0233	cytoplasmic translational termination
HGI45_RS06305	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HGI45_RS06315	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HGI45_RS06320	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGI45_RS06330	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGI45_RS06355	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HGI45_RS06365	COG0839	Belongs to the complex I subunit 6 family
HGI45_RS06375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HGI45_RS06385	COG1007	ATP synthesis coupled electron transport
HGI45_RS06420	COG0159	tryptophan synthase activity
HGI45_RS06425	COG0133	tryptophan synthase activity
HGI45_RS06430	COG0135	phosphoribosylanthranilate isomerase activity
HGI45_RS06430	COG0134	indole-3-glycerol-phosphate synthase activity
HGI45_RS06440	COG0512	Glutamine amidotransferase of anthranilate synthase
HGI45_RS06445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HGI45_RS06450	COG0859	PFAM glycosyl transferase family 9
HGI45_RS06460	COG2353	YceI-like domain
HGI45_RS06465	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HGI45_RS06495	COG0202	RNA polymerase activity
HGI45_RS06520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HGI45_RS06525	COG0024	Methionine aminopeptidase
HGI45_RS06530	COG0201	protein transport
HGI45_RS06570	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HGI45_RS06585	COG0255	Belongs to the universal ribosomal protein uL29 family
HGI45_RS06620	COG0088	Forms part of the polypeptide exit tunnel
HGI45_RS06625	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HGI45_RS06645	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HGI45_RS06655	COG0114	fumarate hydratase activity
HGI45_RS06675	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HGI45_RS06680	COG1687	branched-chain amino acid
HGI45_RS06685	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HGI45_RS06690	COG0484	heat shock protein binding
HGI45_RS06710	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HGI45_RS06720	COG0811	peptide transport
HGI45_RS06725	COG0848	biopolymer transport protein
HGI45_RS06730	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HGI45_RS06740	COG0861	Integral membrane protein TerC family
HGI45_RS06745	COG0598	Magnesium transport protein CorA
HGI45_RS06755	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HGI45_RS06765	COG0204	Acyl-transferase
HGI45_RS06775	COG0793	Belongs to the peptidase S41A family
HGI45_RS06810	COG0157	Belongs to the NadC ModD family
HGI45_RS06815	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HGI45_RS06835	COG0109	protoheme IX farnesyltransferase activity
HGI45_RS06845	COG0305	Participates in initiation and elongation during chromosome replication
HGI45_RS06850	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HGI45_RS06850	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HGI45_RS06855	COG0642	Histidine kinase
HGI45_RS06860	COG0745	RESPONSE REGULATOR receiver
HGI45_RS06880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HGI45_RS06885	COG2176	DNA-directed DNA polymerase activity
HGI45_RS06890	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HGI45_RS06905	COG0497	DNA recombination
HGI45_RS06925	COG0686	Belongs to the AlaDH PNT family
HGI45_RS06930	COG0833	amino acid
HGI45_RS06935	COG0010	Belongs to the arginase family
HGI45_RS06950	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HGI45_RS06960	COG0732	type I restriction modification DNA specificity domain
HGI45_RS06965	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HGI45_RS06970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HGI45_RS06985	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HGI45_RS07000	COG0708	Exodeoxyribonuclease III
HGI45_RS07015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HGI45_RS07050	COG0195	Participates in both transcription termination and antitermination
HGI45_RS07055	COG1921	L-seryl-tRNASec selenium transferase activity
HGI45_RS07075	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HGI45_RS07080	COG0348	domain, Protein
HGI45_RS07090	COG0786	glutamate:sodium symporter activity
HGI45_RS07100	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HGI45_RS07105	COG2217	Heavy metal translocating P-type atpase
HGI45_RS07135	COG0193	aminoacyl-tRNA hydrolase activity
HGI45_RS07145	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HGI45_RS07150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HGI45_RS07160	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HGI45_RS07165	COG0306	phosphate transporter
HGI45_RS07170	COG1253	flavin adenine dinucleotide binding
HGI45_RS07180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGI45_RS07195	COG1739	Uncharacterized protein family UPF0029
HGI45_RS07200	COG1981	membrane
HGI45_RS07205	COG2226	methyltransferase
HGI45_RS07210	COG1722	exodeoxyribonuclease VII activity
HGI45_RS07230	COG0210	DNA helicase
HGI45_RS07240	COG0163	prenyltransferase activity
HGI45_RS07245	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HGI45_RS07275	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGI45_RS07275	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGI45_RS07285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HGI45_RS07295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HGI45_RS07300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HGI45_RS07325	COG0587	DNA-directed DNA polymerase activity
HGI45_RS07330	COG1187	pseudouridine synthase activity
HGI45_RS07335	COG3118	belongs to the thioredoxin family
HGI45_RS07365	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HGI45_RS07375	COG0706	membrane insertase activity
HGI45_RS07380	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HGI45_RS07385	COG0594	ribonuclease P activity
HGI45_RS07395	COG0848	biopolymer transport protein
HGI45_RS07400	COG0811	peptide transport
HGI45_RS07405	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HGI45_RS07410	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HGI45_RS07415	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HGI45_RS07420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HGI45_RS07465	COG0616	signal peptide processing
HGI45_RS07470	COG0788	formyltetrahydrofolate deformylase activity
HGI45_RS07480	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HGI45_RS07485	COG0517	IMP dehydrogenase activity
HGI45_RS07485	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HGI45_RS07490	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HGI45_RS07515	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HGI45_RS07520	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HGI45_RS07525	COG4962	Type ii secretion system protein e
HGI45_RS07530	COG1157	protein secretion by the type III secretion system
HGI45_RS07535	COG1987	bacterial-type flagellum assembly
HGI45_RS07540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HGI45_RS07560	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HGI45_RS07565	COG0799	negative regulation of ribosome biogenesis
HGI45_RS07570	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HGI45_RS07615	COG1295	ribonuclease BN
HGI45_RS07630	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HGI45_RS07640	COG0287	Prephenate dehydrogenase
HGI45_RS07645	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HGI45_RS07650	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGI45_RS07665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HGI45_RS07670	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HGI45_RS07675	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HGI45_RS07680	COG1077	Cell shape determining protein MreB Mrl
HGI45_RS07695	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HGI45_RS07710	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HGI45_RS07720	COG1074	ATP-dependent DNA helicase activity
HGI45_RS07730	COG1862	Preprotein translocase
HGI45_RS07735	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HGI45_RS07740	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HGI45_RS07750	COG0495	leucyl-tRNA aminoacylation
HGI45_RS07760	COG0285	dihydrofolate synthase activity
HGI45_RS07770	COG0739	heme binding
HGI45_RS07780	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HGI45_RS07785	COG0723	plastoquinol--plastocyanin reductase activity
HGI45_RS07805	COG1106	Psort location Cytoplasmic, score
HGI45_RS07810	COG0768	penicillin binding
HGI45_RS07825	COG1558	bacterial-type flagellum-dependent cell motility
HGI45_RS07830	COG1815	bacterial-type flagellum-dependent cell motility
HGI45_RS07835	COG0772	Belongs to the SEDS family
HGI45_RS07850	COG0450	alkyl hydroperoxide reductase
HGI45_RS07860	COG0768	penicillin binding
HGI45_RS07870	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HGI45_RS07885	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HGI45_RS07890	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HGI45_RS07895	COG0741	lytic transglycosylase activity
HGI45_RS07895	COG1388	LysM domain
HGI45_RS07900	COG0084	hydrolase, TatD family'
HGI45_RS07905	COG0307	riboflavin synthase, alpha
HGI45_RS07915	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HGI45_RS07920	COG2011	ABC-type metal ion transport system permease component
HGI45_RS07930	COG0671	phosphoesterase, PA-phosphatase related
HGI45_RS07935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HGI45_RS07945	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HGI45_RS07950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HGI45_RS07955	COG4786	Flagellar basal body rod
HGI45_RS07960	COG4735	regulation of single-species biofilm formation
HGI45_RS07970	COG4735	regulation of single-species biofilm formation