locus-tag	class	description
HGK50_RS00020	COG0288	reversible hydration of carbon dioxide
HGK50_RS00070	COG0358	DNA primase activity
HGK50_RS00110	COG0835	chemotaxis
HGK50_RS00110	COG0784	Response regulator, receiver
HGK50_RS00120	COG0671	phosphoesterase, PA-phosphatase related
HGK50_RS00125	COG2194	sulfuric ester hydrolase activity
HGK50_RS00135	COG0372	Belongs to the citrate synthase family
HGK50_RS00140	COG0538	isocitrate dehydrogenase activity
HGK50_RS00160	COG0589	response to stress
HGK50_RS00165	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HGK50_RS00220	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HGK50_RS00235	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HGK50_RS00265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HGK50_RS00270	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HGK50_RS00270	COG0506	proline dehydrogenase activity
HGK50_RS00270	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HGK50_RS00335	COG0830	nickel cation binding
HGK50_RS00355	COG0831	urea catabolic process
HGK50_RS00355	COG0832	Belongs to the urease beta subunit family
HGK50_RS00380	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HGK50_RS00400	COG0840	transmembrane signaling receptor activity
HGK50_RS00430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HGK50_RS00435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HGK50_RS00440	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HGK50_RS00475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGK50_RS00485	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HGK50_RS00495	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HGK50_RS00505	COG1216	Glycosyl transferase, family 2
HGK50_RS00515	COG0737	Belongs to the 5'-nucleotidase family
HGK50_RS00525	COG0626	cystathionine gamma-synthase activity
HGK50_RS00530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HGK50_RS00550	COG1420	regulation of RNA biosynthetic process
HGK50_RS00570	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HGK50_RS00580	COG0731	radical SAM domain protein
HGK50_RS00590	COG0574	Belongs to the PEP-utilizing enzyme family
HGK50_RS00590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HGK50_RS00600	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HGK50_RS00630	COG1760	l-serine dehydratase
HGK50_RS00635	COG0814	amino acid
HGK50_RS00640	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HGK50_RS00645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HGK50_RS00655	COG1139	Iron-sulfur cluster binding protein
HGK50_RS00660	COG0247	lactate metabolic process
HGK50_RS00665	COG1620	l-lactate permease
HGK50_RS00670	COG1620	l-lactate permease
HGK50_RS00675	COG1194	a g-specific adenine glycosylase
HGK50_RS00680	COG0471	metal ion transport
HGK50_RS00685	COG3278	Belongs to the heme-copper respiratory oxidase family
HGK50_RS00735	COG0148	phosphopyruvate hydratase activity
HGK50_RS00765	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HGK50_RS00775	COG0113	porphobilinogen synthase activity
HGK50_RS00780	COG0642	Histidine kinase
HGK50_RS00785	COG0745	RESPONSE REGULATOR receiver
HGK50_RS00800	COG0826	peptidase U32
HGK50_RS00815	COG0303	'Molybdopterin
HGK50_RS00830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HGK50_RS00835	COG0191	fructose-bisphosphate aldolase activity
HGK50_RS00845	COG2089	acid synthase
HGK50_RS00850	COG1136	(ABC) transporter
HGK50_RS00855	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HGK50_RS00900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGK50_RS00905	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HGK50_RS00910	COG1053	succinate dehydrogenase
HGK50_RS00925	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HGK50_RS00985	COG0489	protein tyrosine kinase activity
HGK50_RS01000	COG0326	Molecular chaperone. Has ATPase activity
HGK50_RS01005	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HGK50_RS01020	COG0471	metal ion transport
HGK50_RS01025	COG0575	Belongs to the CDS family
HGK50_RS01035	COG1881	PFAM PEBP family protein
HGK50_RS01045	COG1104	cysteine desulfurase activity
HGK50_RS01060	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HGK50_RS01065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGK50_RS01065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGK50_RS01070	COG0730	response to heat
HGK50_RS01080	COG0659	secondary active sulfate transmembrane transporter activity
HGK50_RS01110	COG0754	glutathionylspermidine amidase activity
HGK50_RS01120	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HGK50_RS01160	COG0783	Belongs to the Dps family
HGK50_RS01165	COG0642	Histidine kinase
HGK50_RS01170	COG3951	Flagellar rod assembly protein muramidase FlgJ
HGK50_RS01195	COG4172	Belongs to the ABC transporter superfamily
HGK50_RS01200	COG4239	(ABC) transporter, permease
HGK50_RS01235	COG0750	zinc metalloprotease
HGK50_RS01270	COG0785	Cytochrome C biogenesis protein
HGK50_RS01275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HGK50_RS01280	COG0402	S-adenosylhomocysteine deaminase activity
HGK50_RS01315	COG0727	PFAM Uncharacterised protein family (UPF0153)
HGK50_RS01325	COG0134	indole-3-glycerol-phosphate synthase activity
HGK50_RS01335	COG0248	Ppx GppA phosphatase
HGK50_RS01340	COG0859	PFAM glycosyl transferase family 9
HGK50_RS01370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HGK50_RS01375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HGK50_RS01395	COG0019	diaminopimelate decarboxylase activity
HGK50_RS01410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HGK50_RS01435	COG0747	negative chemotaxis
HGK50_RS01440	COG0601	transmembrane transport
HGK50_RS01445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGK50_RS01450	COG0444	Belongs to the ABC transporter superfamily
HGK50_RS01455	COG4608	Belongs to the ABC transporter superfamily
HGK50_RS01475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HGK50_RS01490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HGK50_RS01505	COG0523	cobalamin synthesis protein
HGK50_RS01515	COG0748	coenzyme F420 binding
HGK50_RS01550	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HGK50_RS01555	COG3980	spore coat polysaccharide biosynthesis protein
HGK50_RS01560	COG3980	spore coat polysaccharide biosynthesis protein
HGK50_RS01565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HGK50_RS01570	COG1663	tetraacyldisaccharide 4'-kinase activity
HGK50_RS01590	COG2894	cell division
HGK50_RS01600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HGK50_RS01600	COG0758	DNA mediated transformation
HGK50_RS01610	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HGK50_RS01655	COG0564	pseudouridine synthase activity
HGK50_RS01660	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HGK50_RS01660	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HGK50_RS01665	COG0504	CTP synthase activity
HGK50_RS01675	COG1766	The M ring may be actively involved in energy transduction
HGK50_RS01680	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGK50_RS01690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HGK50_RS01710	COG4786	Flagellar basal body rod
HGK50_RS01715	COG0477	Major facilitator Superfamily
HGK50_RS01720	COG1674	ftsk spoiiie
HGK50_RS01730	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HGK50_RS01735	COG0196	riboflavin kinase activity
HGK50_RS01740	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HGK50_RS01760	COG1132	(ABC) transporter
HGK50_RS01775	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HGK50_RS01795	COG2608	mercury ion transmembrane transporter activity
HGK50_RS01800	COG2217	Heavy metal translocating P-type atpase
HGK50_RS01805	COG1183	phosphatidylcholine synthase activity
HGK50_RS01815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HGK50_RS01825	COG0745	RESPONSE REGULATOR receiver
HGK50_RS01850	COG0357	Ribosomal RNA small subunit methyltransferase G
HGK50_RS01860	COG0805	protein transport
HGK50_RS01905	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HGK50_RS01915	COG0083	homoserine kinase activity
HGK50_RS01945	COG1408	metallophosphoesterase
HGK50_RS01950	COG0745	RESPONSE REGULATOR receiver
HGK50_RS01955	COG2404	hydrolase activity, acting on ester bonds
HGK50_RS01960	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HGK50_RS01980	COG0006	proline dipeptidase activity
HGK50_RS01985	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HGK50_RS01990	COG1419	protein localization to endoplasmic reticulum
HGK50_RS01995	COG0455	bacterial-type flagellum organization
HGK50_RS02010	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGK50_RS02015	COG1776	CheC inhibitor of MCP methylation
HGK50_RS02015	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGK50_RS02030	COG0735	belongs to the Fur family
HGK50_RS02035	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HGK50_RS02035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HGK50_RS02040	COG0789	Transcriptional regulator
HGK50_RS02045	COG0484	heat shock protein binding
HGK50_RS02060	COG0745	RESPONSE REGULATOR receiver
HGK50_RS02065	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HGK50_RS02065	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HGK50_RS02075	COG0833	amino acid
HGK50_RS02080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HGK50_RS02090	COG1028	Short-chain dehydrogenase reductase Sdr
HGK50_RS02110	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HGK50_RS02130	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HGK50_RS02210	COG1217	gtp-binding protein TYPA
HGK50_RS02285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HGK50_RS02295	COG0824	Thioesterase
HGK50_RS02300	COG0733	neurotransmitter:sodium symporter activity
HGK50_RS02305	COG0733	neurotransmitter:sodium symporter activity
HGK50_RS02315	COG0592	DNA-directed DNA polymerase activity
HGK50_RS02320	COG0187	DNA topoisomerase II activity
HGK50_RS02335	COG1196	nuclear chromosome segregation
HGK50_RS02335	COG0741	lytic transglycosylase activity
HGK50_RS02335	COG0739	heme binding
HGK50_RS02350	COG0277	FAD linked oxidase domain protein
HGK50_RS02365	COG0174	glutamine synthetase
HGK50_RS02515	COG3451	type IV secretory pathway VirB4
HGK50_RS02535	COG1842	Phage shock protein A
HGK50_RS02545	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HGK50_RS02555	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HGK50_RS02560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HGK50_RS02590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HGK50_RS02600	COG1028	Short-chain dehydrogenase reductase Sdr
HGK50_RS02630	COG0628	permease
HGK50_RS02640	COG0012	GTP binding
HGK50_RS02655	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HGK50_RS02665	COG0698	ribose 5-phosphate isomerase
HGK50_RS02670	COG1994	Peptidase M50
HGK50_RS02675	COG0681	Belongs to the peptidase S26 family
HGK50_RS02715	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGK50_RS02715	COG1776	CheC inhibitor of MCP methylation
HGK50_RS02720	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HGK50_RS02725	COG1918	ferrous iron import across plasma membrane
HGK50_RS02745	COG0674	pyruvate-flavodoxin oxidoreductase activity
HGK50_RS02745	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HGK50_RS02750	COG1013	pyruvate-flavodoxin oxidoreductase activity
HGK50_RS02785	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HGK50_RS02790	COG0156	8-amino-7-oxononanoate synthase activity
HGK50_RS02805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HGK50_RS02870	COG0784	Response regulator, receiver
HGK50_RS02870	COG0835	chemotaxis
HGK50_RS02885	COG3306	glycosyltransferase involved in LPS biosynthesis
HGK50_RS02895	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HGK50_RS02910	COG1193	negative regulation of DNA recombination
HGK50_RS02925	COG0436	Aminotransferase
HGK50_RS02935	COG2171	N-acyltransferase activity
HGK50_RS02950	COG2249	NAD(P)H dehydrogenase (quinone) activity
HGK50_RS02955	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HGK50_RS02960	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HGK50_RS02965	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HGK50_RS02970	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HGK50_RS02975	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HGK50_RS03000	COG0617	tRNA 3'-terminal CCA addition
HGK50_RS03005	COG0778	Nitroreductase
HGK50_RS03040	COG1027	Aspartate ammonia-lyase
HGK50_RS03055	COG0560	Phosphoserine phosphatase
HGK50_RS03060	COG1528	Iron-storage protein
HGK50_RS03065	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HGK50_RS03075	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HGK50_RS03085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HGK50_RS03100	COG0328	RNA-DNA hybrid ribonuclease activity
HGK50_RS03105	COG0571	ribonuclease III activity
HGK50_RS03120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HGK50_RS03155	COG4974	Belongs to the 'phage' integrase family
HGK50_RS03175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGK50_RS03195	COG1338	Plays a role in the flagellum-specific transport system
HGK50_RS03205	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HGK50_RS03230	COG0183	Belongs to the thiolase family
HGK50_RS03235	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HGK50_RS03240	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HGK50_RS03245	COG2031	fatty acid transporter
HGK50_RS03260	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HGK50_RS03265	COG4647	ligase activity
HGK50_RS03280	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HGK50_RS03285	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HGK50_RS03295	COG2204	response regulator
HGK50_RS03315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HGK50_RS03335	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HGK50_RS03355	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HGK50_RS03360	COG1137	ATPase activity
HGK50_RS03370	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HGK50_RS03390	COG0252	asparaginase activity
HGK50_RS03395	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HGK50_RS03410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HGK50_RS03415	COG0037	tRNA processing
HGK50_RS03455	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HGK50_RS03460	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HGK50_RS03465	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HGK50_RS03480	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HGK50_RS03490	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HGK50_RS03500	COG0772	Belongs to the SEDS family
HGK50_RS03510	COG0564	pseudouridine synthase activity
HGK50_RS03525	COG2884	Cell division ATP-binding protein ftsE
HGK50_RS03545	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HGK50_RS03575	COG2056	Na+-H+ antiporter family
HGK50_RS03580	COG0534	Mate efflux family protein
HGK50_RS03600	COG0552	protein localization to endoplasmic reticulum
HGK50_RS03625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HGK50_RS03635	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HGK50_RS03645	COG0860	N-Acetylmuramoyl-L-alanine amidase
HGK50_RS03655	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HGK50_RS03660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HGK50_RS03680	COG1049	propionate catabolic process, 2-methylcitrate cycle
HGK50_RS03710	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HGK50_RS03730	COG0732	type I restriction modification DNA specificity domain
HGK50_RS03735	COG2217	Heavy metal translocating P-type atpase
HGK50_RS03740	COG0606	chelatase, subunit chli
HGK50_RS03775	COG0521	Mo-molybdopterin cofactor biosynthetic process
HGK50_RS03780	COG0314	molybdopterin synthase activity
HGK50_RS03800	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HGK50_RS03800	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HGK50_RS03825	COG1580	Controls the rotational direction of flagella during chemotaxis
HGK50_RS03845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGK50_RS03850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HGK50_RS03855	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HGK50_RS03860	COG1360	Flagellar Motor Protein
HGK50_RS03870	COG1732	Glycine betaine
HGK50_RS03875	COG1125	glycine betaine transport
HGK50_RS03875	COG0517	IMP dehydrogenase activity
HGK50_RS03895	COG0460	homoserine dehydrogenase
HGK50_RS03905	COG3118	belongs to the thioredoxin family
HGK50_RS03910	COG0492	ferredoxin-NADP+ reductase activity
HGK50_RS03920	COG0724	RNA recognition motif
HGK50_RS03930	COG0517	IMP dehydrogenase activity
HGK50_RS03930	COG0516	GMP reductase activity
HGK50_RS03940	COG0237	dephospho-CoA kinase activity
HGK50_RS03960	COG0776	regulation of translation
HGK50_RS03985	COG1086	Polysaccharide biosynthesis protein
HGK50_RS03990	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HGK50_RS04005	COG0351	phosphomethylpyrimidine kinase
HGK50_RS04020	COG0732	type I restriction modification DNA specificity domain
HGK50_RS04150	COG0358	DNA primase activity
HGK50_RS04180	COG0582	viral genome integration into host DNA
HGK50_RS04190	COG0671	phosphoesterase, PA-phosphatase related
HGK50_RS04200	COG0488	(ABC) transporter
HGK50_RS04220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGK50_RS04225	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HGK50_RS04235	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HGK50_RS04270	COG0375	protein maturation
HGK50_RS04275	COG1749	Flagellar hook protein flgE
HGK50_RS04280	COG2134	cdp-diacylglycerol pyrophosphatase
HGK50_RS04285	COG2824	Alkylphosphonate utilization operon protein PhnA
HGK50_RS04300	COG0753	catalase activity
HGK50_RS04360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGK50_RS04365	COG0300	oxidoreductase activity
HGK50_RS04370	COG1607	acyl-coa hydrolase
HGK50_RS04375	COG3041	Addiction module toxin RelE StbE family
HGK50_RS04405	COG0409	Hydrogenase expression formation protein
HGK50_RS04410	COG0298	carbon dioxide binding
HGK50_RS04415	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HGK50_RS04430	COG0280	phosphate acetyltransferase
HGK50_RS04440	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HGK50_RS04445	COG1749	Flagellar hook protein flgE
HGK50_RS04445	COG1749	Flagellar hook protein flgE
HGK50_RS04490	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HGK50_RS04495	COG0670	Belongs to the BI1 family
HGK50_RS04500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HGK50_RS04515	COG1942	4-Oxalocrotonate Tautomerase
HGK50_RS04540	COG0142	geranyltranstransferase activity
HGK50_RS04555	COG0720	synthase
HGK50_RS04560	COG0602	queuosine metabolic process
HGK50_RS04600	COG0765	amino acid transport
HGK50_RS04605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGK50_RS04615	COG1115	amino acid carrier protein
HGK50_RS04620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGK50_RS04625	COG0251	oxidation-reduction process
HGK50_RS04655	COG1757	Na H antiporter
HGK50_RS04675	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HGK50_RS04685	COG1546	Belongs to the CinA family
HGK50_RS04685	COG1058	Belongs to the CinA family
HGK50_RS04705	COG0564	pseudouridine synthase activity
HGK50_RS04710	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HGK50_RS04710	COG1519	Transferase
HGK50_RS04720	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HGK50_RS04770	COG0675	Transposase, IS605 OrfB family
HGK50_RS04780	COG3451	type IV secretory pathway VirB4
HGK50_RS04785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HGK50_RS04845	COG3041	Addiction module toxin RelE StbE family
HGK50_RS04870	COG3550	peptidyl-serine autophosphorylation
HGK50_RS04885	COG3177	Filamentation induced by cAMP protein fic
HGK50_RS04890	COG4974	Belongs to the 'phage' integrase family
HGK50_RS04910	COG3309	Virulence-associated protein D
HGK50_RS04945	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HGK50_RS04955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HGK50_RS04965	COG0849	cell division
HGK50_RS04970	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HGK50_RS04985	COG0668	transmembrane transport
HGK50_RS05000	COG0675	Transposase, IS605 OrfB family
HGK50_RS05025	COG1166	arginine decarboxylase activity
HGK50_RS05050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGK50_RS05050	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGK50_RS05055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HGK50_RS05060	COG0668	transmembrane transport
HGK50_RS05110	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HGK50_RS05115	COG0537	adenosine 5'-monophosphoramidase activity
HGK50_RS05125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGK50_RS05125	COG0072	phenylalanine-tRNA ligase activity
HGK50_RS05140	COG0539	negative regulation of cytoplasmic translation
HGK50_RS05140	COG1185	polyribonucleotide nucleotidyltransferase activity
HGK50_RS05150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HGK50_RS05155	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HGK50_RS05160	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HGK50_RS05170	COG0835	chemotaxis
HGK50_RS05170	COG0784	Response regulator, receiver
HGK50_RS05175	COG0643	Histidine kinase
HGK50_RS05175	COG2198	Histidine kinase
HGK50_RS05175	COG0784	Response regulator, receiver
HGK50_RS05180	COG0835	chemotaxis
HGK50_RS05185	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HGK50_RS05190	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HGK50_RS05200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HGK50_RS05225	COG0501	Belongs to the peptidase M48B family
HGK50_RS05230	COG2890	protein-(glutamine-N5) methyltransferase activity
HGK50_RS05245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HGK50_RS05245	COG1333	cytochrome c biogenesis protein
HGK50_RS05265	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HGK50_RS05280	COG0511	ligase activity, forming carbon-carbon bonds
HGK50_RS05285	COG0439	Biotin carboxylase
HGK50_RS05305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HGK50_RS05315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGK50_RS05320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HGK50_RS05355	COG4221	oxidoreductase activity
HGK50_RS05360	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HGK50_RS05365	COG0800	Aldolase
HGK50_RS05370	COG0129	dihydroxy-acid dehydratase activity
HGK50_RS05375	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HGK50_RS05380	COG0363	glucosamine-6-phosphate deaminase activity
HGK50_RS05390	COG1064	alcohol dehydrogenase
HGK50_RS05420	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HGK50_RS05430	COG0674	pyruvate-flavodoxin oxidoreductase activity
HGK50_RS05435	COG1013	pyruvate-flavodoxin oxidoreductase activity
HGK50_RS05440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HGK50_RS05470	COG0405	Gamma-glutamyltransferase
HGK50_RS05500	COG1047	Peptidyl-prolyl cis-trans
HGK50_RS05510	COG2885	chlorophyll binding
HGK50_RS05515	COG0823	Involved in the tonB-independent uptake of proteins
HGK50_RS05525	COG0848	biopolymer transport protein
HGK50_RS05530	COG0811	peptide transport
HGK50_RS05540	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HGK50_RS05570	COG1475	DNA binding
HGK50_RS05575	COG1192	Involved in chromosome partitioning
HGK50_RS05585	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HGK50_RS05630	COG0228	four-way junction DNA binding
HGK50_RS05635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HGK50_RS05640	COG0525	valine-tRNA ligase activity
HGK50_RS05665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HGK50_RS05670	COG2184	nucleotidyltransferase activity
HGK50_RS05690	COG0716	FMN binding
HGK50_RS05725	COG1966	Carbon starvation protein
HGK50_RS05735	COG0765	amino acid transport
HGK50_RS05740	COG1126	abc transporter atp-binding protein
HGK50_RS05755	COG0738	Major facilitator superfamily
HGK50_RS05760	COG2252	PERMEase
HGK50_RS05780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HGK50_RS05790	COG2814	Major facilitator Superfamily
HGK50_RS05795	COG0037	tRNA processing
HGK50_RS05800	COG0475	glutathione-regulated potassium exporter activity
HGK50_RS05800	COG0569	domain protein
HGK50_RS05805	COG0534	Mate efflux family protein
HGK50_RS05810	COG2814	Major facilitator Superfamily
HGK50_RS05825	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HGK50_RS05835	COG0859	PFAM glycosyl transferase family 9
HGK50_RS05885	COG0250	Participates in transcription elongation, termination and antitermination
HGK50_RS05930	COG1132	(ABC) transporter
HGK50_RS05950	COG1045	serine acetyltransferase
HGK50_RS05965	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HGK50_RS05985	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HGK50_RS05995	COG0151	Belongs to the GarS family
HGK50_RS06000	COG1131	(ABC) transporter
HGK50_RS06005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HGK50_RS06030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HGK50_RS06035	COG2863	cytochrome
HGK50_RS06045	COG0527	aspartate kinase activity
HGK50_RS06060	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HGK50_RS06070	COG0697	spore germination
HGK50_RS06085	COG0505	Belongs to the CarA family
HGK50_RS06130	COG0629	single-stranded DNA binding
HGK50_RS06140	COG1466	dna polymerase III delta subunit
HGK50_RS06145	COG0557	exoribonuclease II activity
HGK50_RS06160	COG4174	ABC transporter (Permease)
HGK50_RS06165	COG4166	transmembrane transport
HGK50_RS06170	COG0180	Tryptophanyl-tRNA synthetase
HGK50_RS06180	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HGK50_RS06200	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HGK50_RS06205	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGK50_RS06215	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGK50_RS06250	COG0839	Belongs to the complex I subunit 6 family
HGK50_RS06260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HGK50_RS06270	COG1007	ATP synthesis coupled electron transport
HGK50_RS06295	COG0133	tryptophan synthase activity
HGK50_RS06300	COG0135	phosphoribosylanthranilate isomerase activity
HGK50_RS06300	COG0134	indole-3-glycerol-phosphate synthase activity
HGK50_RS06310	COG0512	Glutamine amidotransferase of anthranilate synthase
HGK50_RS06320	COG0859	PFAM glycosyl transferase family 9
HGK50_RS06330	COG2353	YceI-like domain
HGK50_RS06335	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HGK50_RS06360	COG0202	RNA polymerase activity
HGK50_RS06385	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HGK50_RS06390	COG0024	Methionine aminopeptidase
HGK50_RS06395	COG0201	protein transport
HGK50_RS06450	COG0255	Belongs to the universal ribosomal protein uL29 family
HGK50_RS06490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HGK50_RS06520	COG0114	fumarate hydratase activity
HGK50_RS06535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGK50_RS06540	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HGK50_RS06545	COG1687	branched-chain amino acid
HGK50_RS06550	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HGK50_RS06555	COG0484	heat shock protein binding
HGK50_RS06585	COG0811	peptide transport
HGK50_RS06590	COG0848	biopolymer transport protein
HGK50_RS06595	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HGK50_RS06605	COG0861	Integral membrane protein TerC family
HGK50_RS06610	COG0598	Magnesium transport protein CorA
HGK50_RS06615	COG0126	phosphoglycerate kinase activity
HGK50_RS06620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HGK50_RS06630	COG0204	Acyl-transferase
HGK50_RS06640	COG0793	Belongs to the peptidase S41A family
HGK50_RS06665	COG0157	Belongs to the NadC ModD family
HGK50_RS06670	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HGK50_RS06690	COG0109	protoheme IX farnesyltransferase activity
HGK50_RS06700	COG0305	Participates in initiation and elongation during chromosome replication
HGK50_RS06705	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HGK50_RS06705	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HGK50_RS06710	COG0642	Histidine kinase
HGK50_RS06715	COG0745	RESPONSE REGULATOR receiver
HGK50_RS06740	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HGK50_RS06755	COG1077	Cell shape determining protein MreB Mrl
HGK50_RS06760	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HGK50_RS06780	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGK50_RS06785	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HGK50_RS06790	COG0287	Prephenate dehydrogenase
HGK50_RS06800	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HGK50_RS06805	COG3421	Type III restriction
HGK50_RS06815	COG1295	ribonuclease BN
HGK50_RS06850	COG0799	negative regulation of ribosome biogenesis
HGK50_RS06855	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HGK50_RS06875	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HGK50_RS06880	COG1987	bacterial-type flagellum assembly
HGK50_RS06885	COG1157	protein secretion by the type III secretion system
HGK50_RS06890	COG4962	Type ii secretion system protein e
HGK50_RS06900	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HGK50_RS06920	COG0517	IMP dehydrogenase activity
HGK50_RS06920	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HGK50_RS06925	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HGK50_RS06945	COG0788	formyltetrahydrofolate deformylase activity
HGK50_RS06950	COG0616	signal peptide processing
HGK50_RS06985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HGK50_RS06990	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HGK50_RS06995	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HGK50_RS07005	COG0811	peptide transport
HGK50_RS07010	COG0848	biopolymer transport protein
HGK50_RS07030	COG0706	membrane insertase activity
HGK50_RS07040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HGK50_RS07070	COG3118	belongs to the thioredoxin family
HGK50_RS07075	COG1187	pseudouridine synthase activity
HGK50_RS07080	COG0587	DNA-directed DNA polymerase activity
HGK50_RS07105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HGK50_RS07110	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HGK50_RS07120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HGK50_RS07130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGK50_RS07130	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGK50_RS07160	COG0163	prenyltransferase activity
HGK50_RS07195	COG2226	methyltransferase
HGK50_RS07200	COG1981	membrane
HGK50_RS07205	COG1739	Uncharacterized protein family UPF0029
HGK50_RS07220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGK50_RS07230	COG1253	flavin adenine dinucleotide binding
HGK50_RS07235	COG0306	phosphate transporter
HGK50_RS07240	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HGK50_RS07250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HGK50_RS07295	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HGK50_RS07320	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HGK50_RS07340	COG1921	L-seryl-tRNASec selenium transferase activity
HGK50_RS07345	COG0195	Participates in both transcription termination and antitermination
HGK50_RS07370	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HGK50_RS07385	COG0708	Exodeoxyribonuclease III
HGK50_RS07415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HGK50_RS07420	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HGK50_RS07425	COG0732	type I restriction modification DNA specificity domain
HGK50_RS07440	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HGK50_RS07450	COG4772	TonB-dependent receptor
HGK50_RS07460	COG0686	Belongs to the AlaDH PNT family
HGK50_RS07480	COG0497	DNA recombination
HGK50_RS07505	COG2176	DNA-directed DNA polymerase activity
HGK50_RS07510	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HGK50_RS07555	COG1074	ATP-dependent DNA helicase activity
HGK50_RS07565	COG1862	Preprotein translocase
HGK50_RS07570	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HGK50_RS07575	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HGK50_RS07585	COG0495	leucyl-tRNA aminoacylation
HGK50_RS07595	COG0285	dihydrofolate synthase activity
HGK50_RS07605	COG0739	heme binding
HGK50_RS07615	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HGK50_RS07620	COG0723	plastoquinol--plastocyanin reductase activity
HGK50_RS07640	COG0768	penicillin binding
HGK50_RS07655	COG1558	bacterial-type flagellum-dependent cell motility
HGK50_RS07660	COG1815	bacterial-type flagellum-dependent cell motility
HGK50_RS07665	COG0772	Belongs to the SEDS family
HGK50_RS07680	COG0450	alkyl hydroperoxide reductase
HGK50_RS07690	COG0768	penicillin binding
HGK50_RS07715	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HGK50_RS07720	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HGK50_RS07725	COG1388	LysM domain
HGK50_RS07725	COG0741	lytic transglycosylase activity
HGK50_RS07730	COG0084	hydrolase, TatD family'
HGK50_RS07735	COG0307	riboflavin synthase, alpha
HGK50_RS07750	COG2011	ABC-type metal ion transport system permease component
HGK50_RS07760	COG0671	phosphoesterase, PA-phosphatase related
HGK50_RS07765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HGK50_RS07785	COG4786	Flagellar basal body rod
HGK50_RS07800	COG4735	regulation of single-species biofilm formation