locus-tag	class	description
HPAKL117_RS00020	COG0288	reversible hydration of carbon dioxide
HPAKL117_RS00075	COG0358	DNA primase activity
HPAKL117_RS00080	COG0482	sulfurtransferase activity
HPAKL117_RS00110	COG0784	Response regulator, receiver
HPAKL117_RS00110	COG0835	chemotaxis
HPAKL117_RS00120	COG0671	phosphoesterase, PA-phosphatase related
HPAKL117_RS00125	COG2194	sulfuric ester hydrolase activity
HPAKL117_RS00135	COG0372	Belongs to the citrate synthase family
HPAKL117_RS00140	COG0538	isocitrate dehydrogenase activity
HPAKL117_RS00160	COG0589	response to stress
HPAKL117_RS00165	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPAKL117_RS00220	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HPAKL117_RS00235	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HPAKL117_RS00240	COG2957	Belongs to the agmatine deiminase family
HPAKL117_RS00275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPAKL117_RS00280	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPAKL117_RS00280	COG0506	proline dehydrogenase activity
HPAKL117_RS00280	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPAKL117_RS00350	COG1674	ftsk spoiiie
HPAKL117_RS00365	COG0830	nickel cation binding
HPAKL117_RS00380	COG0804	urea catabolic process
HPAKL117_RS00385	COG0832	Belongs to the urease beta subunit family
HPAKL117_RS00385	COG0831	urea catabolic process
HPAKL117_RS00395	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPAKL117_RS00410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPAKL117_RS00430	COG0840	transmembrane signaling receptor activity
HPAKL117_RS00460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPAKL117_RS00465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPAKL117_RS00470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPAKL117_RS00505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPAKL117_RS00515	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPAKL117_RS00520	COG0840	transmembrane signaling receptor activity
HPAKL117_RS00525	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPAKL117_RS00545	COG0737	Belongs to the 5'-nucleotidase family
HPAKL117_RS00555	COG0626	cystathionine gamma-synthase activity
HPAKL117_RS00560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPAKL117_RS00575	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPAKL117_RS00580	COG1420	regulation of RNA biosynthetic process
HPAKL117_RS00600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPAKL117_RS00605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPAKL117_RS00605	COG0551	DNA topoisomerase type I activity
HPAKL117_RS00610	COG0731	radical SAM domain protein
HPAKL117_RS00620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPAKL117_RS00620	COG0574	Belongs to the PEP-utilizing enzyme family
HPAKL117_RS00635	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HPAKL117_RS00670	COG1760	l-serine dehydratase
HPAKL117_RS00675	COG0814	amino acid
HPAKL117_RS00680	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HPAKL117_RS00690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPAKL117_RS00700	COG1139	Iron-sulfur cluster binding protein
HPAKL117_RS00705	COG0247	lactate metabolic process
HPAKL117_RS00710	COG1620	l-lactate permease
HPAKL117_RS00715	COG1620	l-lactate permease
HPAKL117_RS00720	COG1194	a g-specific adenine glycosylase
HPAKL117_RS00725	COG0471	metal ion transport
HPAKL117_RS00730	COG3278	Belongs to the heme-copper respiratory oxidase family
HPAKL117_RS00810	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPAKL117_RS00820	COG0113	porphobilinogen synthase activity
HPAKL117_RS00825	COG0642	Histidine kinase
HPAKL117_RS00830	COG0745	RESPONSE REGULATOR receiver
HPAKL117_RS00845	COG0826	peptidase U32
HPAKL117_RS00860	COG0303	'Molybdopterin
HPAKL117_RS00880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPAKL117_RS00885	COG0191	fructose-bisphosphate aldolase activity
HPAKL117_RS00895	COG2089	acid synthase
HPAKL117_RS00900	COG1136	(ABC) transporter
HPAKL117_RS00905	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPAKL117_RS00960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPAKL117_RS00965	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPAKL117_RS00970	COG1053	succinate dehydrogenase
HPAKL117_RS00985	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPAKL117_RS00990	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPAKL117_RS01050	COG0489	protein tyrosine kinase activity
HPAKL117_RS01070	COG0326	Molecular chaperone. Has ATPase activity
HPAKL117_RS01085	COG0471	metal ion transport
HPAKL117_RS01090	COG0575	Belongs to the CDS family
HPAKL117_RS01105	COG1881	PFAM PEBP family protein
HPAKL117_RS01115	COG1104	cysteine desulfurase activity
HPAKL117_RS01130	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPAKL117_RS01135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPAKL117_RS01135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPAKL117_RS01140	COG0730	response to heat
HPAKL117_RS01150	COG0659	secondary active sulfate transmembrane transporter activity
HPAKL117_RS01180	COG0754	glutathionylspermidine amidase activity
HPAKL117_RS01190	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPAKL117_RS01230	COG0783	Belongs to the Dps family
HPAKL117_RS01235	COG0642	Histidine kinase
HPAKL117_RS01240	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPAKL117_RS01265	COG4172	Belongs to the ABC transporter superfamily
HPAKL117_RS01270	COG4239	(ABC) transporter, permease
HPAKL117_RS01305	COG0750	zinc metalloprotease
HPAKL117_RS01325	COG0542	response to heat
HPAKL117_RS01330	COG0785	Cytochrome C biogenesis protein
HPAKL117_RS01335	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPAKL117_RS01340	COG0402	S-adenosylhomocysteine deaminase activity
HPAKL117_RS01375	COG0727	PFAM Uncharacterised protein family (UPF0153)
HPAKL117_RS01385	COG0134	indole-3-glycerol-phosphate synthase activity
HPAKL117_RS01395	COG0248	Ppx GppA phosphatase
HPAKL117_RS01400	COG0859	PFAM glycosyl transferase family 9
HPAKL117_RS01430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPAKL117_RS01435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPAKL117_RS01455	COG0019	diaminopimelate decarboxylase activity
HPAKL117_RS01470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPAKL117_RS01495	COG0747	negative chemotaxis
HPAKL117_RS01500	COG0601	transmembrane transport
HPAKL117_RS01505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPAKL117_RS01510	COG0444	Belongs to the ABC transporter superfamily
HPAKL117_RS01515	COG4608	Belongs to the ABC transporter superfamily
HPAKL117_RS01535	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPAKL117_RS01550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPAKL117_RS01565	COG0523	cobalamin synthesis protein
HPAKL117_RS01575	COG0748	coenzyme F420 binding
HPAKL117_RS01610	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPAKL117_RS01615	COG3980	spore coat polysaccharide biosynthesis protein
HPAKL117_RS01620	COG3980	spore coat polysaccharide biosynthesis protein
HPAKL117_RS01625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPAKL117_RS01650	COG2894	cell division
HPAKL117_RS01660	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPAKL117_RS01660	COG0758	DNA mediated transformation
HPAKL117_RS01665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPAKL117_RS01670	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPAKL117_RS01685	COG0564	pseudouridine synthase activity
HPAKL117_RS01690	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HPAKL117_RS01690	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPAKL117_RS01695	COG0504	CTP synthase activity
HPAKL117_RS01705	COG1766	The M ring may be actively involved in energy transduction
HPAKL117_RS01710	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPAKL117_RS01720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPAKL117_RS01740	COG4786	Flagellar basal body rod
HPAKL117_RS01745	COG0477	Major facilitator Superfamily
HPAKL117_RS01750	COG1674	ftsk spoiiie
HPAKL117_RS01760	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPAKL117_RS01765	COG0196	riboflavin kinase activity
HPAKL117_RS01770	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPAKL117_RS01790	COG1132	(ABC) transporter
HPAKL117_RS01810	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HPAKL117_RS01825	COG2608	mercury ion transmembrane transporter activity
HPAKL117_RS01830	COG2217	Heavy metal translocating P-type atpase
HPAKL117_RS01835	COG1183	phosphatidylcholine synthase activity
HPAKL117_RS01845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPAKL117_RS01855	COG0745	RESPONSE REGULATOR receiver
HPAKL117_RS01880	COG0357	Ribosomal RNA small subunit methyltransferase G
HPAKL117_RS01890	COG0805	protein transport
HPAKL117_RS01935	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPAKL117_RS01945	COG0083	homoserine kinase activity
HPAKL117_RS01970	COG1408	metallophosphoesterase
HPAKL117_RS01975	COG0745	RESPONSE REGULATOR receiver
HPAKL117_RS01980	COG2404	hydrolase activity, acting on ester bonds
HPAKL117_RS01985	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPAKL117_RS02005	COG0006	proline dipeptidase activity
HPAKL117_RS02010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPAKL117_RS02015	COG1419	protein localization to endoplasmic reticulum
HPAKL117_RS02020	COG0455	bacterial-type flagellum organization
HPAKL117_RS02035	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPAKL117_RS02040	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPAKL117_RS02040	COG1776	CheC inhibitor of MCP methylation
HPAKL117_RS02055	COG0735	belongs to the Fur family
HPAKL117_RS02060	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPAKL117_RS02060	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HPAKL117_RS02065	COG0789	Transcriptional regulator
HPAKL117_RS02070	COG0484	heat shock protein binding
HPAKL117_RS02085	COG0745	RESPONSE REGULATOR receiver
HPAKL117_RS02100	COG0833	amino acid
HPAKL117_RS02105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPAKL117_RS02115	COG1028	Short-chain dehydrogenase reductase Sdr
HPAKL117_RS02135	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPAKL117_RS02165	COG4974	Belongs to the 'phage' integrase family
HPAKL117_RS02170	COG3177	Filamentation induced by cAMP protein fic
HPAKL117_RS02210	COG1192	Involved in chromosome partitioning
HPAKL117_RS02225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPAKL117_RS02250	COG4962	Type ii secretion system protein e
HPAKL117_RS02290	COG3451	type IV secretory pathway VirB4
HPAKL117_RS02375	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPAKL117_RS02400	COG1217	gtp-binding protein TYPA
HPAKL117_RS02465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPAKL117_RS02475	COG0824	Thioesterase
HPAKL117_RS02480	COG0733	neurotransmitter:sodium symporter activity
HPAKL117_RS02485	COG0733	neurotransmitter:sodium symporter activity
HPAKL117_RS02495	COG0592	DNA-directed DNA polymerase activity
HPAKL117_RS02500	COG0187	DNA topoisomerase II activity
HPAKL117_RS02515	COG1196	nuclear chromosome segregation
HPAKL117_RS02515	COG0741	lytic transglycosylase activity
HPAKL117_RS02515	COG0739	heme binding
HPAKL117_RS02530	COG0277	FAD linked oxidase domain protein
HPAKL117_RS02545	COG0174	glutamine synthetase
HPAKL117_RS02550	COG3586	endonuclease activity
HPAKL117_RS02590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPAKL117_RS02600	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPAKL117_RS02605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPAKL117_RS02630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPAKL117_RS02640	COG1028	Short-chain dehydrogenase reductase Sdr
HPAKL117_RS02670	COG0628	permease
HPAKL117_RS02680	COG0012	GTP binding
HPAKL117_RS02705	COG0698	ribose 5-phosphate isomerase
HPAKL117_RS02710	COG1994	Peptidase M50
HPAKL117_RS02715	COG0681	Belongs to the peptidase S26 family
HPAKL117_RS02720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPAKL117_RS02755	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPAKL117_RS02755	COG1776	CheC inhibitor of MCP methylation
HPAKL117_RS02760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPAKL117_RS02765	COG1918	ferrous iron import across plasma membrane
HPAKL117_RS02785	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPAKL117_RS02785	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPAKL117_RS02790	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPAKL117_RS02815	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPAKL117_RS02820	COG0156	8-amino-7-oxononanoate synthase activity
HPAKL117_RS02825	COG0840	transmembrane signaling receptor activity
HPAKL117_RS02830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPAKL117_RS02880	COG1122	ATPase activity
HPAKL117_RS02895	COG0835	chemotaxis
HPAKL117_RS02895	COG0784	Response regulator, receiver
HPAKL117_RS02920	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPAKL117_RS02925	COG1193	negative regulation of DNA recombination
HPAKL117_RS02940	COG0436	Aminotransferase
HPAKL117_RS02950	COG2171	N-acyltransferase activity
HPAKL117_RS02965	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPAKL117_RS02970	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HPAKL117_RS02975	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HPAKL117_RS02980	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HPAKL117_RS02985	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HPAKL117_RS02990	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HPAKL117_RS03015	COG0617	tRNA 3'-terminal CCA addition
HPAKL117_RS03025	COG0778	Nitroreductase
HPAKL117_RS03035	COG0762	integral membrane protein
HPAKL117_RS03060	COG1027	Aspartate ammonia-lyase
HPAKL117_RS03075	COG0560	Phosphoserine phosphatase
HPAKL117_RS03080	COG1528	Iron-storage protein
HPAKL117_RS03085	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HPAKL117_RS03090	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPAKL117_RS03095	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HPAKL117_RS03140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPAKL117_RS03180	COG4974	Belongs to the 'phage' integrase family
HPAKL117_RS03190	COG0730	response to heat
HPAKL117_RS03200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPAKL117_RS03225	COG1338	Plays a role in the flagellum-specific transport system
HPAKL117_RS03235	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HPAKL117_RS03245	COG0183	Belongs to the thiolase family
HPAKL117_RS03250	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPAKL117_RS03255	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPAKL117_RS03260	COG2031	fatty acid transporter
HPAKL117_RS03270	COG0145	ligase activity
HPAKL117_RS03275	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HPAKL117_RS03280	COG4647	ligase activity
HPAKL117_RS03295	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPAKL117_RS03300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPAKL117_RS03310	COG2204	response regulator
HPAKL117_RS03320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPAKL117_RS03340	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HPAKL117_RS03355	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPAKL117_RS03360	COG1137	ATPase activity
HPAKL117_RS03370	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPAKL117_RS03375	COG1279	arginine transmembrane transporter activity
HPAKL117_RS03395	COG0252	asparaginase activity
HPAKL117_RS03400	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPAKL117_RS03420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPAKL117_RS03425	COG0037	tRNA processing
HPAKL117_RS03460	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPAKL117_RS03465	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPAKL117_RS03470	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPAKL117_RS03475	COG1181	Belongs to the D-alanine--D-alanine ligase family
HPAKL117_RS03485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPAKL117_RS03495	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPAKL117_RS03510	COG0564	pseudouridine synthase activity
HPAKL117_RS03520	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPAKL117_RS03525	COG2884	Cell division ATP-binding protein ftsE
HPAKL117_RS03545	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPAKL117_RS03575	COG2056	Na+-H+ antiporter family
HPAKL117_RS03580	COG0534	Mate efflux family protein
HPAKL117_RS03600	COG0552	protein localization to endoplasmic reticulum
HPAKL117_RS03625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPAKL117_RS03635	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPAKL117_RS03645	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPAKL117_RS03655	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPAKL117_RS03660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPAKL117_RS03665	COG1758	RNA polymerase activity
HPAKL117_RS03680	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPAKL117_RS03710	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPAKL117_RS03740	COG2217	Heavy metal translocating P-type atpase
HPAKL117_RS03745	COG0606	chelatase, subunit chli
HPAKL117_RS03780	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPAKL117_RS03785	COG0314	molybdopterin synthase activity
HPAKL117_RS03805	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPAKL117_RS03805	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPAKL117_RS03825	COG1580	Controls the rotational direction of flagella during chemotaxis
HPAKL117_RS03845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPAKL117_RS03850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPAKL117_RS03855	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPAKL117_RS03860	COG1360	Flagellar Motor Protein
HPAKL117_RS03880	COG1732	Glycine betaine
HPAKL117_RS03885	COG1125	glycine betaine transport
HPAKL117_RS03885	COG0517	IMP dehydrogenase activity
HPAKL117_RS03905	COG0460	homoserine dehydrogenase
HPAKL117_RS03915	COG3118	belongs to the thioredoxin family
HPAKL117_RS03920	COG0492	ferredoxin-NADP+ reductase activity
HPAKL117_RS03930	COG0724	RNA recognition motif
HPAKL117_RS03940	COG0517	IMP dehydrogenase activity
HPAKL117_RS03940	COG0516	GMP reductase activity
HPAKL117_RS03950	COG0237	dephospho-CoA kinase activity
HPAKL117_RS03970	COG0776	regulation of translation
HPAKL117_RS03995	COG1086	Polysaccharide biosynthesis protein
HPAKL117_RS04000	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPAKL117_RS04015	COG0351	phosphomethylpyrimidine kinase
HPAKL117_RS04040	COG0671	phosphoesterase, PA-phosphatase related
HPAKL117_RS04050	COG0488	(ABC) transporter
HPAKL117_RS04070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPAKL117_RS04075	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPAKL117_RS04085	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HPAKL117_RS04120	COG0375	protein maturation
HPAKL117_RS04125	COG1749	Flagellar hook protein flgE
HPAKL117_RS04130	COG2134	cdp-diacylglycerol pyrophosphatase
HPAKL117_RS04140	COG2824	Alkylphosphonate utilization operon protein PhnA
HPAKL117_RS04155	COG0753	catalase activity
HPAKL117_RS04200	COG0728	peptidoglycan biosynthetic process
HPAKL117_RS04205	COG0215	cysteine-tRNA ligase activity
HPAKL117_RS04215	COG1120	ATPase activity
HPAKL117_RS04220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPAKL117_RS04225	COG0300	oxidoreductase activity
HPAKL117_RS04230	COG1607	acyl-coa hydrolase
HPAKL117_RS04265	COG0409	Hydrogenase expression formation protein
HPAKL117_RS04270	COG0298	carbon dioxide binding
HPAKL117_RS04275	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HPAKL117_RS04295	COG0280	phosphate acetyltransferase
HPAKL117_RS04305	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HPAKL117_RS04310	COG1749	Flagellar hook protein flgE
HPAKL117_RS04310	COG1749	Flagellar hook protein flgE
HPAKL117_RS04355	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPAKL117_RS04360	COG0670	Belongs to the BI1 family
HPAKL117_RS04365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPAKL117_RS04380	COG1942	4-Oxalocrotonate Tautomerase
HPAKL117_RS04405	COG0142	geranyltranstransferase activity
HPAKL117_RS04420	COG0720	synthase
HPAKL117_RS04425	COG0602	queuosine metabolic process
HPAKL117_RS04455	COG0765	amino acid transport
HPAKL117_RS04460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPAKL117_RS04470	COG1115	amino acid carrier protein
HPAKL117_RS04475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPAKL117_RS04480	COG0251	oxidation-reduction process
HPAKL117_RS04510	COG1757	Na H antiporter
HPAKL117_RS04535	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPAKL117_RS04545	COG1546	Belongs to the CinA family
HPAKL117_RS04545	COG1058	Belongs to the CinA family
HPAKL117_RS04565	COG0564	pseudouridine synthase activity
HPAKL117_RS04570	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPAKL117_RS04570	COG1519	Transferase
HPAKL117_RS04580	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPAKL117_RS04605	COG1160	GTP binding
HPAKL117_RS04615	COG3309	Virulence-associated protein D
HPAKL117_RS04650	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPAKL117_RS04655	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPAKL117_RS04660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPAKL117_RS04670	COG0849	cell division
HPAKL117_RS04675	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPAKL117_RS04695	COG0668	transmembrane transport
HPAKL117_RS04705	COG1570	exodeoxyribonuclease VII activity
HPAKL117_RS04810	COG1166	arginine decarboxylase activity
HPAKL117_RS04835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPAKL117_RS04835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPAKL117_RS04840	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPAKL117_RS04845	COG0668	transmembrane transport
HPAKL117_RS04900	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPAKL117_RS04905	COG0537	adenosine 5'-monophosphoramidase activity
HPAKL117_RS04915	COG0072	phenylalanine-tRNA ligase activity
HPAKL117_RS04915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPAKL117_RS04930	COG0539	negative regulation of cytoplasmic translation
HPAKL117_RS04930	COG1185	polyribonucleotide nucleotidyltransferase activity
HPAKL117_RS04940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPAKL117_RS04945	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPAKL117_RS04950	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPAKL117_RS04960	COG0835	chemotaxis
HPAKL117_RS04960	COG0784	Response regulator, receiver
HPAKL117_RS04965	COG2198	Histidine kinase
HPAKL117_RS04965	COG0643	Histidine kinase
HPAKL117_RS04965	COG0784	Response regulator, receiver
HPAKL117_RS04970	COG0835	chemotaxis
HPAKL117_RS04975	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HPAKL117_RS04980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPAKL117_RS04990	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPAKL117_RS05015	COG0501	Belongs to the peptidase M48B family
HPAKL117_RS05020	COG2890	protein-(glutamine-N5) methyltransferase activity
HPAKL117_RS05025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPAKL117_RS05035	COG1333	cytochrome c biogenesis protein
HPAKL117_RS05035	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPAKL117_RS05055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPAKL117_RS05070	COG0511	ligase activity, forming carbon-carbon bonds
HPAKL117_RS05075	COG0439	Biotin carboxylase
HPAKL117_RS05095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPAKL117_RS05105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPAKL117_RS05110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPAKL117_RS05150	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPAKL117_RS05155	COG0800	Aldolase
HPAKL117_RS05160	COG0129	dihydroxy-acid dehydratase activity
HPAKL117_RS05165	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPAKL117_RS05170	COG0363	glucosamine-6-phosphate deaminase activity
HPAKL117_RS05180	COG1064	alcohol dehydrogenase
HPAKL117_RS05200	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPAKL117_RS05210	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPAKL117_RS05215	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPAKL117_RS05220	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPAKL117_RS05250	COG0405	Gamma-glutamyltransferase
HPAKL117_RS05285	COG1047	Peptidyl-prolyl cis-trans
HPAKL117_RS05295	COG2885	chlorophyll binding
HPAKL117_RS05300	COG0823	Involved in the tonB-independent uptake of proteins
HPAKL117_RS05310	COG0848	biopolymer transport protein
HPAKL117_RS05315	COG0811	peptide transport
HPAKL117_RS05325	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPAKL117_RS05355	COG1475	DNA binding
HPAKL117_RS05360	COG1192	Involved in chromosome partitioning
HPAKL117_RS05365	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HPAKL117_RS05365	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HPAKL117_RS05370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPAKL117_RS05420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPAKL117_RS05425	COG0525	valine-tRNA ligase activity
HPAKL117_RS05450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPAKL117_RS05475	COG0716	FMN binding
HPAKL117_RS05510	COG1966	Carbon starvation protein
HPAKL117_RS05520	COG0765	amino acid transport
HPAKL117_RS05525	COG1126	abc transporter atp-binding protein
HPAKL117_RS05545	COG0738	Major facilitator superfamily
HPAKL117_RS05550	COG2252	PERMEase
HPAKL117_RS05570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPAKL117_RS05580	COG2814	Major facilitator Superfamily
HPAKL117_RS05585	COG0037	tRNA processing
HPAKL117_RS05590	COG0569	domain protein
HPAKL117_RS05590	COG0475	glutathione-regulated potassium exporter activity
HPAKL117_RS05595	COG0534	Mate efflux family protein
HPAKL117_RS05615	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPAKL117_RS05625	COG0859	PFAM glycosyl transferase family 9
HPAKL117_RS05675	COG0250	Participates in transcription elongation, termination and antitermination
HPAKL117_RS05720	COG1132	(ABC) transporter
HPAKL117_RS05740	COG1045	serine acetyltransferase
HPAKL117_RS05780	COG0151	Belongs to the GarS family
HPAKL117_RS05790	COG1131	(ABC) transporter
HPAKL117_RS05795	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPAKL117_RS05820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPAKL117_RS05825	COG2863	cytochrome
HPAKL117_RS05835	COG0527	aspartate kinase activity
HPAKL117_RS05850	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPAKL117_RS05860	COG0697	spore germination
HPAKL117_RS05875	COG0505	Belongs to the CarA family
HPAKL117_RS05890	COG0424	maF-like protein
HPAKL117_RS05915	COG0629	single-stranded DNA binding
HPAKL117_RS05925	COG1466	dna polymerase III delta subunit
HPAKL117_RS05930	COG0557	exoribonuclease II activity
HPAKL117_RS05945	COG4174	ABC transporter (Permease)
HPAKL117_RS05950	COG4166	transmembrane transport
HPAKL117_RS05955	COG0180	Tryptophanyl-tRNA synthetase
HPAKL117_RS05965	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPAKL117_RS05985	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPAKL117_RS05990	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPAKL117_RS06000	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPAKL117_RS06035	COG0839	Belongs to the complex I subunit 6 family
HPAKL117_RS06045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPAKL117_RS06055	COG1007	ATP synthesis coupled electron transport
HPAKL117_RS06080	COG0133	tryptophan synthase activity
HPAKL117_RS06085	COG0135	phosphoribosylanthranilate isomerase activity
HPAKL117_RS06085	COG0134	indole-3-glycerol-phosphate synthase activity
HPAKL117_RS06090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPAKL117_RS06095	COG0512	Glutamine amidotransferase of anthranilate synthase
HPAKL117_RS06100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPAKL117_RS06105	COG0859	PFAM glycosyl transferase family 9
HPAKL117_RS06115	COG2353	YceI-like domain
HPAKL117_RS06120	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HPAKL117_RS06140	COG0202	RNA polymerase activity
HPAKL117_RS06165	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPAKL117_RS06170	COG0024	Methionine aminopeptidase
HPAKL117_RS06175	COG0201	protein transport
HPAKL117_RS06210	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPAKL117_RS06230	COG0255	Belongs to the universal ribosomal protein uL29 family
HPAKL117_RS06240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPAKL117_RS06270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPAKL117_RS06300	COG0114	fumarate hydratase activity
HPAKL117_RS06320	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPAKL117_RS06325	COG1687	branched-chain amino acid
HPAKL117_RS06330	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HPAKL117_RS06335	COG0484	heat shock protein binding
HPAKL117_RS06365	COG0811	peptide transport
HPAKL117_RS06370	COG0848	biopolymer transport protein
HPAKL117_RS06375	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPAKL117_RS06385	COG0861	Integral membrane protein TerC family
HPAKL117_RS06390	COG0598	Magnesium transport protein CorA
HPAKL117_RS06395	COG0126	phosphoglycerate kinase activity
HPAKL117_RS06400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPAKL117_RS06410	COG0204	Acyl-transferase
HPAKL117_RS06420	COG0793	Belongs to the peptidase S41A family
HPAKL117_RS06445	COG0157	Belongs to the NadC ModD family
HPAKL117_RS06450	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPAKL117_RS06470	COG0109	protoheme IX farnesyltransferase activity
HPAKL117_RS06480	COG0305	Participates in initiation and elongation during chromosome replication
HPAKL117_RS06485	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPAKL117_RS06485	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPAKL117_RS06490	COG0642	Histidine kinase
HPAKL117_RS06495	COG0745	RESPONSE REGULATOR receiver
HPAKL117_RS06510	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HPAKL117_RS06535	COG1077	Cell shape determining protein MreB Mrl
HPAKL117_RS06540	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPAKL117_RS06555	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HPAKL117_RS06560	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPAKL117_RS06565	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPAKL117_RS06570	COG0287	Prephenate dehydrogenase
HPAKL117_RS06610	COG3041	Addiction module toxin RelE StbE family
HPAKL117_RS06635	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HPAKL117_RS06670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPAKL117_RS06675	COG3451	type IV secretory pathway VirB4
HPAKL117_RS06740	COG0799	negative regulation of ribosome biogenesis
HPAKL117_RS06765	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPAKL117_RS06770	COG1987	bacterial-type flagellum assembly
HPAKL117_RS06775	COG1157	protein secretion by the type III secretion system
HPAKL117_RS06780	COG4962	Type ii secretion system protein e
HPAKL117_RS06790	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPAKL117_RS06810	COG0517	IMP dehydrogenase activity
HPAKL117_RS06810	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPAKL117_RS06815	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPAKL117_RS06835	COG0788	formyltetrahydrofolate deformylase activity
HPAKL117_RS06840	COG0616	signal peptide processing
HPAKL117_RS06880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPAKL117_RS06890	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPAKL117_RS06900	COG0811	peptide transport
HPAKL117_RS06905	COG0848	biopolymer transport protein
HPAKL117_RS06925	COG0706	membrane insertase activity
HPAKL117_RS06935	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPAKL117_RS06965	COG3118	belongs to the thioredoxin family
HPAKL117_RS06970	COG1187	pseudouridine synthase activity
HPAKL117_RS06975	COG0587	DNA-directed DNA polymerase activity
HPAKL117_RS07000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPAKL117_RS07005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPAKL117_RS07015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPAKL117_RS07025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPAKL117_RS07025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPAKL117_RS07055	COG0163	prenyltransferase activity
HPAKL117_RS07090	COG2226	methyltransferase
HPAKL117_RS07095	COG1981	membrane
HPAKL117_RS07100	COG1739	Uncharacterized protein family UPF0029
HPAKL117_RS07115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPAKL117_RS07125	COG1253	flavin adenine dinucleotide binding
HPAKL117_RS07130	COG0306	phosphate transporter
HPAKL117_RS07135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HPAKL117_RS07145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPAKL117_RS07200	COG2217	Heavy metal translocating P-type atpase
HPAKL117_RS07205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HPAKL117_RS07215	COG0786	glutamate:sodium symporter activity
HPAKL117_RS07225	COG0348	domain, Protein
HPAKL117_RS07230	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPAKL117_RS07250	COG1921	L-seryl-tRNASec selenium transferase activity
HPAKL117_RS07255	COG0195	Participates in both transcription termination and antitermination
HPAKL117_RS07270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPAKL117_RS07285	COG0708	Exodeoxyribonuclease III
HPAKL117_RS07320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPAKL117_RS07325	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HPAKL117_RS07330	COG0732	type I restriction modification DNA specificity domain
HPAKL117_RS07340	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HPAKL117_RS07350	COG4772	TonB-dependent receptor
HPAKL117_RS07355	COG0010	Belongs to the arginase family
HPAKL117_RS07360	COG0833	amino acid
HPAKL117_RS07365	COG0686	Belongs to the AlaDH PNT family
HPAKL117_RS07385	COG0497	DNA recombination
HPAKL117_RS07440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPAKL117_RS07445	COG2176	DNA-directed DNA polymerase activity
HPAKL117_RS07480	COG0582	viral genome integration into host DNA
HPAKL117_RS07485	COG1295	ribonuclease BN
HPAKL117_RS07525	COG1074	ATP-dependent DNA helicase activity
HPAKL117_RS07535	COG1862	Preprotein translocase
HPAKL117_RS07540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPAKL117_RS07545	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPAKL117_RS07555	COG0495	leucyl-tRNA aminoacylation
HPAKL117_RS07565	COG0285	dihydrofolate synthase activity
HPAKL117_RS07575	COG0739	heme binding
HPAKL117_RS07585	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPAKL117_RS07590	COG0723	plastoquinol--plastocyanin reductase activity
HPAKL117_RS07610	COG0768	penicillin binding
HPAKL117_RS07620	COG1558	bacterial-type flagellum-dependent cell motility
HPAKL117_RS07625	COG1815	bacterial-type flagellum-dependent cell motility
HPAKL117_RS07630	COG0772	Belongs to the SEDS family
HPAKL117_RS07640	COG0450	alkyl hydroperoxide reductase
HPAKL117_RS07650	COG0768	penicillin binding
HPAKL117_RS07675	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HPAKL117_RS07680	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPAKL117_RS07685	COG1388	LysM domain
HPAKL117_RS07685	COG0741	lytic transglycosylase activity
HPAKL117_RS07690	COG0084	hydrolase, TatD family'
HPAKL117_RS07695	COG0307	riboflavin synthase, alpha
HPAKL117_RS07710	COG2011	ABC-type metal ion transport system permease component
HPAKL117_RS07725	COG0671	phosphoesterase, PA-phosphatase related
HPAKL117_RS07730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPAKL117_RS07750	COG4786	Flagellar basal body rod
HPAKL117_RS07765	COG4735	regulation of single-species biofilm formation
HPAKL117_RS07770	COG4735	regulation of single-species biofilm formation