locus-tag	class	description
HPAKL86_RS00020	COG0288	reversible hydration of carbon dioxide
HPAKL86_RS00065	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HPAKL86_RS00120	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPAKL86_RS00125	COG0589	response to stress
HPAKL86_RS00145	COG0538	isocitrate dehydrogenase activity
HPAKL86_RS00150	COG0372	Belongs to the citrate synthase family
HPAKL86_RS00175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPAKL86_RS00180	COG0671	phosphoesterase, PA-phosphatase related
HPAKL86_RS00225	COG0799	negative regulation of ribosome biogenesis
HPAKL86_RS00250	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HPAKL86_RS00255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPAKL86_RS00290	COG0708	Exodeoxyribonuclease III
HPAKL86_RS00305	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPAKL86_RS00340	COG0133	tryptophan synthase activity
HPAKL86_RS00345	COG0135	phosphoribosylanthranilate isomerase activity
HPAKL86_RS00345	COG0134	indole-3-glycerol-phosphate synthase activity
HPAKL86_RS00355	COG0512	Glutamine amidotransferase of anthranilate synthase
HPAKL86_RS00360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPAKL86_RS00385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPAKL86_RS00430	COG0497	DNA recombination
HPAKL86_RS00450	COG0686	Belongs to the AlaDH PNT family
HPAKL86_RS00455	COG0833	amino acid
HPAKL86_RS00460	COG0010	Belongs to the arginase family
HPAKL86_RS00495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPAKL86_RS00505	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HPAKL86_RS00510	COG0306	phosphate transporter
HPAKL86_RS00515	COG1253	flavin adenine dinucleotide binding
HPAKL86_RS00525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPAKL86_RS00540	COG1739	Uncharacterized protein family UPF0029
HPAKL86_RS00545	COG1981	membrane
HPAKL86_RS00550	COG2226	methyltransferase
HPAKL86_RS00585	COG0163	prenyltransferase activity
HPAKL86_RS00590	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPAKL86_RS00625	COG1295	ribonuclease BN
HPAKL86_RS00635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPAKL86_RS00660	COG0287	Prephenate dehydrogenase
HPAKL86_RS00665	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPAKL86_RS00670	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPAKL86_RS00675	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HPAKL86_RS00680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPAKL86_RS00690	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPAKL86_RS00695	COG1077	Cell shape determining protein MreB Mrl
HPAKL86_RS00715	COG0768	penicillin binding
HPAKL86_RS00725	COG1558	bacterial-type flagellum-dependent cell motility
HPAKL86_RS00730	COG1815	bacterial-type flagellum-dependent cell motility
HPAKL86_RS00735	COG0772	Belongs to the SEDS family
HPAKL86_RS00745	COG0450	alkyl hydroperoxide reductase
HPAKL86_RS00755	COG0768	penicillin binding
HPAKL86_RS00780	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HPAKL86_RS00785	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPAKL86_RS00795	COG0084	hydrolase, TatD family'
HPAKL86_RS00800	COG0307	riboflavin synthase, alpha
HPAKL86_RS00815	COG2011	ABC-type metal ion transport system permease component
HPAKL86_RS00820	COG2194	sulfuric ester hydrolase activity
HPAKL86_RS00825	COG0671	phosphoesterase, PA-phosphatase related
HPAKL86_RS00835	COG0784	Response regulator, receiver
HPAKL86_RS00835	COG0835	chemotaxis
HPAKL86_RS00865	COG0587	DNA-directed DNA polymerase activity
HPAKL86_RS00870	COG1187	pseudouridine synthase activity
HPAKL86_RS00875	COG3118	belongs to the thioredoxin family
HPAKL86_RS00880	COG0114	fumarate hydratase activity
HPAKL86_RS00910	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPAKL86_RS00970	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPAKL86_RS01005	COG0201	protein transport
HPAKL86_RS01010	COG0024	Methionine aminopeptidase
HPAKL86_RS01015	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPAKL86_RS01040	COG0202	RNA polymerase activity
HPAKL86_RS01080	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPAKL86_RS01090	COG0706	membrane insertase activity
HPAKL86_RS01100	COG0594	ribonuclease P activity
HPAKL86_RS01110	COG0848	biopolymer transport protein
HPAKL86_RS01115	COG0811	peptide transport
HPAKL86_RS01125	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPAKL86_RS01135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPAKL86_RS01170	COG0616	signal peptide processing
HPAKL86_RS01175	COG0788	formyltetrahydrofolate deformylase activity
HPAKL86_RS01195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPAKL86_RS01200	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPAKL86_RS01205	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPAKL86_RS01210	COG2863	cytochrome
HPAKL86_RS01215	COG0494	nUDIX hydrolase
HPAKL86_RS01220	COG0527	aspartate kinase activity
HPAKL86_RS01235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPAKL86_RS01245	COG0697	spore germination
HPAKL86_RS01260	COG0505	Belongs to the CarA family
HPAKL86_RS01285	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPAKL86_RS01290	COG1131	(ABC) transporter
HPAKL86_RS01300	COG0151	Belongs to the GarS family
HPAKL86_RS01310	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPAKL86_RS01345	COG1132	(ABC) transporter
HPAKL86_RS01390	COG0250	Participates in transcription elongation, termination and antitermination
HPAKL86_RS01410	COG0222	ribosome binding
HPAKL86_RS01420	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HPAKL86_RS01440	COG0859	PFAM glycosyl transferase family 9
HPAKL86_RS01450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPAKL86_RS01465	COG0489	protein tyrosine kinase activity
HPAKL86_RS01480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPAKL86_RS01485	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPAKL86_RS01485	COG0506	proline dehydrogenase activity
HPAKL86_RS01485	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPAKL86_RS01545	COG1674	ftsk spoiiie
HPAKL86_RS01550	COG0829	nickel cation binding
HPAKL86_RS01560	COG0830	nickel cation binding
HPAKL86_RS01575	COG0804	urea catabolic process
HPAKL86_RS01590	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPAKL86_RS01605	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPAKL86_RS01615	COG0840	transmembrane signaling receptor activity
HPAKL86_RS01645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPAKL86_RS01650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPAKL86_RS01655	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPAKL86_RS01685	COG0326	Molecular chaperone. Has ATPase activity
HPAKL86_RS01690	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPAKL86_RS01705	COG0471	metal ion transport
HPAKL86_RS01710	COG0575	Belongs to the CDS family
HPAKL86_RS01720	COG1881	PFAM PEBP family protein
HPAKL86_RS01730	COG1104	cysteine desulfurase activity
HPAKL86_RS01740	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPAKL86_RS01745	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPAKL86_RS01745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPAKL86_RS01750	COG0730	response to heat
HPAKL86_RS01770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPAKL86_RS01780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPAKL86_RS01785	COG0840	transmembrane signaling receptor activity
HPAKL86_RS01790	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPAKL86_RS01795	COG0731	radical SAM domain protein
HPAKL86_RS01800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPAKL86_RS01800	COG0551	DNA topoisomerase type I activity
HPAKL86_RS01805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPAKL86_RS01820	COG1420	regulation of RNA biosynthetic process
HPAKL86_RS01825	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPAKL86_RS01840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPAKL86_RS01845	COG0626	cystathionine gamma-synthase activity
HPAKL86_RS01855	COG0737	Belongs to the 5'-nucleotidase family
HPAKL86_RS01865	COG1216	Glycosyl transferase, family 2
HPAKL86_RS01875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPAKL86_RS01875	COG0574	Belongs to the PEP-utilizing enzyme family
HPAKL86_RS01890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HPAKL86_RS01940	COG0012	GTP binding
HPAKL86_RS01965	COG0698	ribose 5-phosphate isomerase
HPAKL86_RS01970	COG1994	Peptidase M50
HPAKL86_RS01975	COG0681	Belongs to the peptidase S26 family
HPAKL86_RS02015	COG1776	CheC inhibitor of MCP methylation
HPAKL86_RS02015	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPAKL86_RS02020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPAKL86_RS02025	COG1918	ferrous iron import across plasma membrane
HPAKL86_RS02045	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPAKL86_RS02045	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPAKL86_RS02050	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPAKL86_RS02085	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPAKL86_RS02090	COG0156	8-amino-7-oxononanoate synthase activity
HPAKL86_RS02095	COG0840	transmembrane signaling receptor activity
HPAKL86_RS02115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPAKL86_RS02180	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPAKL86_RS02220	COG0783	Belongs to the Dps family
HPAKL86_RS02225	COG0642	Histidine kinase
HPAKL86_RS02230	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPAKL86_RS02255	COG4172	Belongs to the ABC transporter superfamily
HPAKL86_RS02260	COG4239	(ABC) transporter, permease
HPAKL86_RS02295	COG0750	zinc metalloprotease
HPAKL86_RS02315	COG0492	ferredoxin-NADP+ reductase activity
HPAKL86_RS02330	COG0716	FMN binding
HPAKL86_RS02340	COG2184	nucleotidyltransferase activity
HPAKL86_RS02345	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPAKL86_RS02360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPAKL86_RS02370	COG0525	valine-tRNA ligase activity
HPAKL86_RS02375	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPAKL86_RS02395	COG0336	Belongs to the RNA methyltransferase TrmD family
HPAKL86_RS02410	COG1115	amino acid carrier protein
HPAKL86_RS02415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPAKL86_RS02420	COG0251	oxidation-reduction process
HPAKL86_RS02450	COG1757	Na H antiporter
HPAKL86_RS02460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPAKL86_RS02465	COG0765	amino acid transport
HPAKL86_RS02500	COG1749	Flagellar hook protein flgE
HPAKL86_RS02500	COG1749	Flagellar hook protein flgE
HPAKL86_RS02505	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HPAKL86_RS02515	COG0280	phosphate acetyltransferase
HPAKL86_RS02520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPAKL86_RS02530	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HPAKL86_RS02535	COG0298	carbon dioxide binding
HPAKL86_RS02540	COG0409	Hydrogenase expression formation protein
HPAKL86_RS02570	COG1607	acyl-coa hydrolase
HPAKL86_RS02575	COG0300	oxidoreductase activity
HPAKL86_RS02580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPAKL86_RS02585	COG1120	ATPase activity
HPAKL86_RS02605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPAKL86_RS02620	COG0542	response to heat
HPAKL86_RS02625	COG0785	Cytochrome C biogenesis protein
HPAKL86_RS02630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPAKL86_RS02635	COG0402	S-adenosylhomocysteine deaminase activity
HPAKL86_RS02670	COG0727	PFAM Uncharacterised protein family (UPF0153)
HPAKL86_RS02680	COG0134	indole-3-glycerol-phosphate synthase activity
HPAKL86_RS02685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPAKL86_RS02690	COG0248	Ppx GppA phosphatase
HPAKL86_RS02695	COG0859	PFAM glycosyl transferase family 9
HPAKL86_RS02725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPAKL86_RS02730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPAKL86_RS02750	COG0019	diaminopimelate decarboxylase activity
HPAKL86_RS02765	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPAKL86_RS02770	COG2134	cdp-diacylglycerol pyrophosphatase
HPAKL86_RS02775	COG1749	Flagellar hook protein flgE
HPAKL86_RS02780	COG0375	protein maturation
HPAKL86_RS02800	COG0756	dUTP diphosphatase activity
HPAKL86_RS02825	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPAKL86_RS02830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPAKL86_RS02850	COG0488	(ABC) transporter
HPAKL86_RS02860	COG0671	phosphoesterase, PA-phosphatase related
HPAKL86_RS02880	COG2089	acid synthase
HPAKL86_RS02890	COG1083	cytidylyl-transferase
HPAKL86_RS02910	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPAKL86_RS02915	COG1086	Polysaccharide biosynthesis protein
HPAKL86_RS02940	COG0776	regulation of translation
HPAKL86_RS02960	COG0237	dephospho-CoA kinase activity
HPAKL86_RS02970	COG0517	IMP dehydrogenase activity
HPAKL86_RS02970	COG0516	GMP reductase activity
HPAKL86_RS02980	COG0724	RNA recognition motif
HPAKL86_RS02985	COG1106	Psort location Cytoplasmic, score
HPAKL86_RS03000	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HPAKL86_RS03020	COG2608	mercury ion transmembrane transporter activity
HPAKL86_RS03025	COG2217	Heavy metal translocating P-type atpase
HPAKL86_RS03030	COG1183	phosphatidylcholine synthase activity
HPAKL86_RS03040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPAKL86_RS03050	COG0745	RESPONSE REGULATOR receiver
HPAKL86_RS03075	COG0357	Ribosomal RNA small subunit methyltransferase G
HPAKL86_RS03085	COG0805	protein transport
HPAKL86_RS03130	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPAKL86_RS03140	COG0083	homoserine kinase activity
HPAKL86_RS03170	COG1408	metallophosphoesterase
HPAKL86_RS03180	COG0745	RESPONSE REGULATOR receiver
HPAKL86_RS03185	COG2404	hydrolase activity, acting on ester bonds
HPAKL86_RS03190	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPAKL86_RS03210	COG0006	proline dipeptidase activity
HPAKL86_RS03215	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPAKL86_RS03220	COG1419	protein localization to endoplasmic reticulum
HPAKL86_RS03225	COG0455	bacterial-type flagellum organization
HPAKL86_RS03240	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPAKL86_RS03245	COG1776	CheC inhibitor of MCP methylation
HPAKL86_RS03245	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPAKL86_RS03260	COG0735	belongs to the Fur family
HPAKL86_RS03265	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPAKL86_RS03265	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HPAKL86_RS03270	COG0789	Transcriptional regulator
HPAKL86_RS03275	COG0484	heat shock protein binding
HPAKL86_RS03290	COG0745	RESPONSE REGULATOR receiver
HPAKL86_RS03305	COG0833	amino acid
HPAKL86_RS03310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPAKL86_RS03320	COG1028	Short-chain dehydrogenase reductase Sdr
HPAKL86_RS03340	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPAKL86_RS03425	COG1217	gtp-binding protein TYPA
HPAKL86_RS03460	COG0602	queuosine metabolic process
HPAKL86_RS03465	COG0720	synthase
HPAKL86_RS03480	COG0142	geranyltranstransferase activity
HPAKL86_RS03505	COG1942	4-Oxalocrotonate Tautomerase
HPAKL86_RS03520	COG0523	cobalamin synthesis protein
HPAKL86_RS03530	COG0748	coenzyme F420 binding
HPAKL86_RS03540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPAKL86_RS03565	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPAKL86_RS03570	COG3980	spore coat polysaccharide biosynthesis protein
HPAKL86_RS03575	COG3980	spore coat polysaccharide biosynthesis protein
HPAKL86_RS03580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPAKL86_RS03585	COG1663	tetraacyldisaccharide 4'-kinase activity
HPAKL86_RS03605	COG2894	cell division
HPAKL86_RS03615	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPAKL86_RS03615	COG0758	DNA mediated transformation
HPAKL86_RS03625	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPAKL86_RS03640	COG0564	pseudouridine synthase activity
HPAKL86_RS03645	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPAKL86_RS03645	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HPAKL86_RS03650	COG0504	CTP synthase activity
HPAKL86_RS03660	COG1766	The M ring may be actively involved in energy transduction
HPAKL86_RS03665	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPAKL86_RS03675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPAKL86_RS03700	COG2204	response regulator
HPAKL86_RS03710	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPAKL86_RS03715	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPAKL86_RS03725	COG0183	Belongs to the thiolase family
HPAKL86_RS03730	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPAKL86_RS03735	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPAKL86_RS03740	COG2031	fatty acid transporter
HPAKL86_RS03755	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HPAKL86_RS03760	COG4647	ligase activity
HPAKL86_RS03765	COG0252	asparaginase activity
HPAKL86_RS03770	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPAKL86_RS03780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPAKL86_RS03795	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPAKL86_RS03830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPAKL86_RS03845	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPAKL86_RS03845	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPAKL86_RS03885	COG0606	chelatase, subunit chli
HPAKL86_RS03890	COG2217	Heavy metal translocating P-type atpase
HPAKL86_RS03920	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPAKL86_RS03945	COG0741	lytic transglycosylase activity
HPAKL86_RS03945	COG1196	nuclear chromosome segregation
HPAKL86_RS03945	COG0739	heme binding
HPAKL86_RS03960	COG0277	FAD linked oxidase domain protein
HPAKL86_RS03975	COG0174	glutamine synthetase
HPAKL86_RS03980	COG3586	endonuclease activity
HPAKL86_RS04020	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPAKL86_RS04030	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPAKL86_RS04060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPAKL86_RS04100	COG0628	permease
HPAKL86_RS04105	COG4786	Flagellar basal body rod
HPAKL86_RS04110	COG0477	Major facilitator Superfamily
HPAKL86_RS04115	COG1674	ftsk spoiiie
HPAKL86_RS04125	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPAKL86_RS04130	COG0196	riboflavin kinase activity
HPAKL86_RS04135	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPAKL86_RS04155	COG1132	(ABC) transporter
HPAKL86_RS04190	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPAKL86_RS04200	COG0824	Thioesterase
HPAKL86_RS04205	COG0733	neurotransmitter:sodium symporter activity
HPAKL86_RS04210	COG0733	neurotransmitter:sodium symporter activity
HPAKL86_RS04220	COG0592	DNA-directed DNA polymerase activity
HPAKL86_RS04225	COG0187	DNA topoisomerase II activity
HPAKL86_RS04255	COG1580	Controls the rotational direction of flagella during chemotaxis
HPAKL86_RS04260	COG0736	holo-[acyl-carrier-protein] synthase activity
HPAKL86_RS04270	COG0784	Response regulator, receiver
HPAKL86_RS04270	COG0835	chemotaxis
HPAKL86_RS04285	COG3306	glycosyltransferase involved in LPS biosynthesis
HPAKL86_RS04300	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPAKL86_RS04315	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HPAKL86_RS04320	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPAKL86_RS04325	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HPAKL86_RS04335	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPAKL86_RS04370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPAKL86_RS04400	COG4974	Belongs to the 'phage' integrase family
HPAKL86_RS04410	COG0730	response to heat
HPAKL86_RS04420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPAKL86_RS04430	COG1338	Plays a role in the flagellum-specific transport system
HPAKL86_RS04435	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HPAKL86_RS04465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPAKL86_RS04470	COG0617	tRNA 3'-terminal CCA addition
HPAKL86_RS04495	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HPAKL86_RS04500	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HPAKL86_RS04505	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HPAKL86_RS04510	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HPAKL86_RS04515	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HPAKL86_RS04520	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPAKL86_RS04540	COG0460	homoserine dehydrogenase
HPAKL86_RS04545	COG0792	nuclease activity
HPAKL86_RS04550	COG3118	belongs to the thioredoxin family
HPAKL86_RS04555	COG0492	ferredoxin-NADP+ reductase activity
HPAKL86_RS04575	COG2171	N-acyltransferase activity
HPAKL86_RS04585	COG0436	Aminotransferase
HPAKL86_RS04600	COG1193	negative regulation of DNA recombination
HPAKL86_RS04605	COG0517	IMP dehydrogenase activity
HPAKL86_RS04605	COG1125	glycine betaine transport
HPAKL86_RS04610	COG1732	Glycine betaine
HPAKL86_RS04615	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HPAKL86_RS04630	COG1360	Flagellar Motor Protein
HPAKL86_RS04635	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPAKL86_RS04640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPAKL86_RS04685	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPAKL86_RS04690	COG0670	Belongs to the BI1 family
HPAKL86_RS04695	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPAKL86_RS04700	COG0726	polysaccharide deacetylase
HPAKL86_RS04705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPAKL86_RS04720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPAKL86_RS04740	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPAKL86_RS04750	COG1058	Belongs to the CinA family
HPAKL86_RS04750	COG1546	Belongs to the CinA family
HPAKL86_RS04760	COG0778	Nitroreductase
HPAKL86_RS04770	COG0564	pseudouridine synthase activity
HPAKL86_RS04775	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPAKL86_RS04775	COG1519	Transferase
HPAKL86_RS04785	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPAKL86_RS04800	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPAKL86_RS04815	COG3309	Virulence-associated protein D
HPAKL86_RS04850	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPAKL86_RS04860	COG1528	Iron-storage protein
HPAKL86_RS04865	COG0560	Phosphoserine phosphatase
HPAKL86_RS04880	COG1027	Aspartate ammonia-lyase
HPAKL86_RS04900	COG0741	lytic transglycosylase activity
HPAKL86_RS04905	COG0762	integral membrane protein
HPAKL86_RS04915	COG0037	tRNA processing
HPAKL86_RS04945	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPAKL86_RS04950	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPAKL86_RS04955	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPAKL86_RS04970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPAKL86_RS04980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPAKL86_RS05000	COG0564	pseudouridine synthase activity
HPAKL86_RS05010	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPAKL86_RS05015	COG2884	Cell division ATP-binding protein ftsE
HPAKL86_RS05035	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPAKL86_RS05065	COG2056	Na+-H+ antiporter family
HPAKL86_RS05070	COG0534	Mate efflux family protein
HPAKL86_RS05075	COG1418	mRNA catabolic process
HPAKL86_RS05090	COG0552	protein localization to endoplasmic reticulum
HPAKL86_RS05115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPAKL86_RS05125	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPAKL86_RS05135	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPAKL86_RS05150	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPAKL86_RS05160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPAKL86_RS05165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPAKL86_RS05170	COG1758	RNA polymerase activity
HPAKL86_RS05180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPAKL86_RS05190	COG0849	cell division
HPAKL86_RS05195	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPAKL86_RS05200	COG0668	transmembrane transport
HPAKL86_RS05255	COG1166	arginine decarboxylase activity
HPAKL86_RS05280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPAKL86_RS05280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPAKL86_RS05285	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPAKL86_RS05290	COG0668	transmembrane transport
HPAKL86_RS05300	COG0405	Gamma-glutamyltransferase
HPAKL86_RS05330	COG1047	Peptidyl-prolyl cis-trans
HPAKL86_RS05340	COG2885	chlorophyll binding
HPAKL86_RS05355	COG0848	biopolymer transport protein
HPAKL86_RS05360	COG0811	peptide transport
HPAKL86_RS05400	COG1475	DNA binding
HPAKL86_RS05405	COG1192	Involved in chromosome partitioning
HPAKL86_RS05410	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HPAKL86_RS05410	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HPAKL86_RS05415	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPAKL86_RS05450	COG4608	Belongs to the ABC transporter superfamily
HPAKL86_RS05455	COG0444	Belongs to the ABC transporter superfamily
HPAKL86_RS05460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPAKL86_RS05465	COG0601	transmembrane transport
HPAKL86_RS05470	COG0747	negative chemotaxis
HPAKL86_RS05490	COG2824	Alkylphosphonate utilization operon protein PhnA
HPAKL86_RS05505	COG0753	catalase activity
HPAKL86_RS05540	COG0728	peptidoglycan biosynthetic process
HPAKL86_RS05565	COG0439	Biotin carboxylase
HPAKL86_RS05570	COG0511	ligase activity, forming carbon-carbon bonds
HPAKL86_RS05585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPAKL86_RS05605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPAKL86_RS05605	COG1333	cytochrome c biogenesis protein
HPAKL86_RS05615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPAKL86_RS05620	COG2890	protein-(glutamine-N5) methyltransferase activity
HPAKL86_RS05625	COG0501	Belongs to the peptidase M48B family
HPAKL86_RS05685	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPAKL86_RS05690	COG0537	adenosine 5'-monophosphoramidase activity
HPAKL86_RS05700	COG0072	phenylalanine-tRNA ligase activity
HPAKL86_RS05700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPAKL86_RS05715	COG0539	negative regulation of cytoplasmic translation
HPAKL86_RS05715	COG1185	polyribonucleotide nucleotidyltransferase activity
HPAKL86_RS05725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPAKL86_RS05730	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPAKL86_RS05735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPAKL86_RS05745	COG0784	Response regulator, receiver
HPAKL86_RS05745	COG0835	chemotaxis
HPAKL86_RS05750	COG0643	Histidine kinase
HPAKL86_RS05750	COG0784	Response regulator, receiver
HPAKL86_RS05750	COG2198	Histidine kinase
HPAKL86_RS05755	COG0835	chemotaxis
HPAKL86_RS05795	COG4221	oxidoreductase activity
HPAKL86_RS05800	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPAKL86_RS05805	COG0800	Aldolase
HPAKL86_RS05810	COG0129	dihydroxy-acid dehydratase activity
HPAKL86_RS05815	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPAKL86_RS05820	COG0363	glucosamine-6-phosphate deaminase activity
HPAKL86_RS05830	COG1064	alcohol dehydrogenase
HPAKL86_RS05850	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPAKL86_RS05860	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPAKL86_RS05865	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPAKL86_RS05870	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPAKL86_RS05895	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPAKL86_RS05900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPAKL86_RS05910	COG0101	tRNA pseudouridine synthase activity
HPAKL86_RS05930	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HPAKL86_RS05935	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPAKL86_RS05945	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPAKL86_RS05960	COG1966	Carbon starvation protein
HPAKL86_RS05970	COG0765	amino acid transport
HPAKL86_RS05975	COG1126	abc transporter atp-binding protein
HPAKL86_RS05990	COG0738	Major facilitator superfamily
HPAKL86_RS05995	COG2252	PERMEase
HPAKL86_RS06020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPAKL86_RS06030	COG2814	Major facilitator Superfamily
HPAKL86_RS06035	COG0037	tRNA processing
HPAKL86_RS06040	COG0475	glutathione-regulated potassium exporter activity
HPAKL86_RS06040	COG0569	domain protein
HPAKL86_RS06050	COG2814	Major facilitator Superfamily
HPAKL86_RS06120	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPAKL86_RS06125	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPAKL86_RS06140	COG1053	succinate dehydrogenase
HPAKL86_RS06145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPAKL86_RS06150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPAKL86_RS06195	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPAKL86_RS06200	COG1136	(ABC) transporter
HPAKL86_RS06205	COG2089	acid synthase
HPAKL86_RS06235	COG0191	fructose-bisphosphate aldolase activity
HPAKL86_RS06240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPAKL86_RS06270	COG0826	peptidase U32
HPAKL86_RS06285	COG0217	transcriptional regulatory protein
HPAKL86_RS06290	COG0113	porphobilinogen synthase activity
HPAKL86_RS06295	COG0642	Histidine kinase
HPAKL86_RS06300	COG0745	RESPONSE REGULATOR receiver
HPAKL86_RS06305	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPAKL86_RS06390	COG3278	Belongs to the heme-copper respiratory oxidase family
HPAKL86_RS06395	COG0471	metal ion transport
HPAKL86_RS06400	COG1194	a g-specific adenine glycosylase
HPAKL86_RS06405	COG1620	l-lactate permease
HPAKL86_RS06410	COG1620	l-lactate permease
HPAKL86_RS06415	COG0247	lactate metabolic process
HPAKL86_RS06420	COG1139	Iron-sulfur cluster binding protein
HPAKL86_RS06430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPAKL86_RS06440	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HPAKL86_RS06445	COG0814	amino acid
HPAKL86_RS06450	COG1760	l-serine dehydratase
HPAKL86_RS06460	COG0754	glutathionylspermidine amidase activity
HPAKL86_RS06495	COG1045	serine acetyltransferase
HPAKL86_RS06515	COG0723	plastoquinol--plastocyanin reductase activity
HPAKL86_RS06520	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPAKL86_RS06530	COG0739	heme binding
HPAKL86_RS06540	COG0285	dihydrofolate synthase activity
HPAKL86_RS06550	COG0495	leucyl-tRNA aminoacylation
HPAKL86_RS06560	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPAKL86_RS06565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPAKL86_RS06570	COG1862	Preprotein translocase
HPAKL86_RS06580	COG1074	ATP-dependent DNA helicase activity
HPAKL86_RS06605	COG0793	Belongs to the peptidase S41A family
HPAKL86_RS06615	COG0204	Acyl-transferase
HPAKL86_RS06625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPAKL86_RS06630	COG1987	bacterial-type flagellum assembly
HPAKL86_RS06635	COG1157	protein secretion by the type III secretion system
HPAKL86_RS06640	COG4962	Type ii secretion system protein e
HPAKL86_RS06650	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPAKL86_RS06675	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPAKL86_RS06680	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPAKL86_RS06680	COG0517	IMP dehydrogenase activity
HPAKL86_RS06700	COG0424	maF-like protein
HPAKL86_RS06725	COG0629	single-stranded DNA binding
HPAKL86_RS06735	COG1466	dna polymerase III delta subunit
HPAKL86_RS06740	COG0557	exoribonuclease II activity
HPAKL86_RS06755	COG4174	ABC transporter (Permease)
HPAKL86_RS06760	COG4166	transmembrane transport
HPAKL86_RS06765	COG0180	Tryptophanyl-tRNA synthetase
HPAKL86_RS06775	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPAKL86_RS06795	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPAKL86_RS06800	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPAKL86_RS06810	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPAKL86_RS06845	COG0839	Belongs to the complex I subunit 6 family
HPAKL86_RS06855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPAKL86_RS06865	COG1007	ATP synthesis coupled electron transport
HPAKL86_RS06890	COG2353	YceI-like domain
HPAKL86_RS06900	COG0859	PFAM glycosyl transferase family 9
HPAKL86_RS06910	COG0157	Belongs to the NadC ModD family
HPAKL86_RS06915	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPAKL86_RS06935	COG0109	protoheme IX farnesyltransferase activity
HPAKL86_RS06945	COG0305	Participates in initiation and elongation during chromosome replication
HPAKL86_RS06950	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPAKL86_RS06950	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPAKL86_RS06955	COG0642	Histidine kinase
HPAKL86_RS06960	COG0745	RESPONSE REGULATOR receiver
HPAKL86_RS07000	COG2957	Belongs to the agmatine deiminase family
HPAKL86_RS07005	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HPAKL86_RS07025	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HPAKL86_RS07035	COG0786	glutamate:sodium symporter activity
HPAKL86_RS07045	COG0348	domain, Protein
HPAKL86_RS07050	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPAKL86_RS07070	COG1921	L-seryl-tRNASec selenium transferase activity
HPAKL86_RS07075	COG0195	Participates in both transcription termination and antitermination
HPAKL86_RS07100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPAKL86_RS07110	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPAKL86_RS07110	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPAKL86_RS07120	COG0482	sulfurtransferase activity
HPAKL86_RS07125	COG0358	DNA primase activity
HPAKL86_RS07135	COG0459	protein refolding
HPAKL86_RS07145	COG0861	Integral membrane protein TerC family
HPAKL86_RS07150	COG0598	Magnesium transport protein CorA
HPAKL86_RS07155	COG0126	phosphoglycerate kinase activity
HPAKL86_RS07160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPAKL86_RS07165	COG1687	branched-chain amino acid
HPAKL86_RS07170	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HPAKL86_RS07175	COG0484	heat shock protein binding
HPAKL86_RS07210	COG0811	peptide transport
HPAKL86_RS07215	COG0848	biopolymer transport protein
HPAKL86_RS07220	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPAKL86_RS07230	COG4786	Flagellar basal body rod