locus-tag	class	description
U064_RS00010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
U064_RS00015	COG2877	3-deoxy-8-phosphooctulonate synthase activity
U064_RS00020	COG0288	reversible hydration of carbon dioxide
U064_RS00065	COG0459	protein refolding
U064_RS00070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
U064_RS00075	COG0358	DNA primase activity
U064_RS00080	COG0482	sulfurtransferase activity
U064_RS00110	COG0784	Response regulator, receiver
U064_RS00110	COG0835	chemotaxis
U064_RS00120	COG0671	phosphoesterase, PA-phosphatase related
U064_RS00125	COG2194	sulfuric ester hydrolase activity
U064_RS00135	COG0372	Belongs to the citrate synthase family
U064_RS00140	COG0538	isocitrate dehydrogenase activity
U064_RS00150	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
U064_RS00160	COG0589	response to stress
U064_RS00165	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
U064_RS00170	COG0542	response to heat
U064_RS00220	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
U064_RS00245	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
U064_RS00250	COG2957	Belongs to the agmatine deiminase family
U064_RS00275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
U064_RS00310	COG0157	Belongs to the NadC ModD family
U064_RS00315	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
U064_RS00335	COG0109	protoheme IX farnesyltransferase activity
U064_RS00345	COG0305	Participates in initiation and elongation during chromosome replication
U064_RS00350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
U064_RS00350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
U064_RS00355	COG0642	Histidine kinase
U064_RS00360	COG0745	RESPONSE REGULATOR receiver
U064_RS00365	COG2189	Belongs to the N(4) N(6)-methyltransferase family
U064_RS00380	COG1077	Cell shape determining protein MreB Mrl
U064_RS00385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
U064_RS00395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
U064_RS00400	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
U064_RS00405	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U064_RS00410	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
U064_RS00415	COG0287	Prephenate dehydrogenase
U064_RS00425	COG2189	Belongs to the N(4) N(6)-methyltransferase family
U064_RS00430	COG3421	Type III restriction
U064_RS00440	COG1295	ribonuclease BN
U064_RS00500	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
U064_RS00505	COG0799	negative regulation of ribosome biogenesis
U064_RS00545	COG0505	Belongs to the CarA family
U064_RS00560	COG0697	spore germination
U064_RS00570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
U064_RS00585	COG0527	aspartate kinase activity
U064_RS00590	COG0494	nUDIX hydrolase
U064_RS00595	COG2863	cytochrome
U064_RS00600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
U064_RS00625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
U064_RS00630	COG1131	(ABC) transporter
U064_RS00640	COG0151	Belongs to the GarS family
U064_RS00650	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
U064_RS00680	COG1045	serine acetyltransferase
U064_RS00700	COG1132	(ABC) transporter
U064_RS00745	COG0250	Participates in transcription elongation, termination and antitermination
U064_RS00775	COG0085	RNA polymerase activity
U064_RS00775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
U064_RS00800	COG0859	PFAM glycosyl transferase family 9
U064_RS00805	COG0124	histidyl-tRNA synthetase
U064_RS00810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
U064_RS00840	COG0569	domain protein
U064_RS00840	COG0475	glutathione-regulated potassium exporter activity
U064_RS00845	COG0037	tRNA processing
U064_RS00850	COG2814	Major facilitator Superfamily
U064_RS00860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
U064_RS00865	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
U064_RS00870	COG0813	purine-nucleoside phosphorylase activity
U064_RS00885	COG2252	PERMEase
U064_RS00890	COG0738	Major facilitator superfamily
U064_RS00905	COG1126	abc transporter atp-binding protein
U064_RS00910	COG0765	amino acid transport
U064_RS00920	COG1966	Carbon starvation protein
U064_RS00940	COG0492	ferredoxin-NADP+ reductase activity
U064_RS00955	COG0716	FMN binding
U064_RS00965	COG2184	nucleotidyltransferase activity
U064_RS00970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
U064_RS00985	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
U064_RS00995	COG0525	valine-tRNA ligase activity
U064_RS01000	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
U064_RS01015	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
U064_RS01020	COG0336	Belongs to the RNA methyltransferase TrmD family
U064_RS01025	COG0335	large ribosomal subunit rRNA binding
U064_RS01110	COG3550	peptidyl-serine autophosphorylation
U064_RS01115	COG4974	Belongs to the 'phage' integrase family
U064_RS01140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
U064_RS01200	COG0788	formyltetrahydrofolate deformylase activity
U064_RS01220	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
U064_RS01225	COG0517	IMP dehydrogenase activity
U064_RS01225	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
U064_RS01245	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
U064_RS01250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
U064_RS01255	COG4962	Type ii secretion system protein e
U064_RS01260	COG1157	protein secretion by the type III secretion system
U064_RS01265	COG1987	bacterial-type flagellum assembly
U064_RS01270	COG0812	UDP-N-acetylmuramate dehydrogenase activity
U064_RS01290	COG0793	Belongs to the peptidase S41A family
U064_RS01300	COG0204	Acyl-transferase
U064_RS01310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
U064_RS01315	COG0126	phosphoglycerate kinase activity
U064_RS01320	COG0598	Magnesium transport protein CorA
U064_RS01325	COG0861	Integral membrane protein TerC family
U064_RS01340	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
U064_RS01345	COG0848	biopolymer transport protein
U064_RS01350	COG0811	peptide transport
U064_RS01355	COG0864	Transcriptional regulator
U064_RS01360	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
U064_RS01370	COG0482	sulfurtransferase activity
U064_RS01380	COG0484	heat shock protein binding
U064_RS01385	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
U064_RS01390	COG1687	branched-chain amino acid
U064_RS01395	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U064_RS01400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U064_RS01415	COG0114	fumarate hydratase activity
U064_RS01445	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
U064_RS01460	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
U064_RS01465	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
U064_RS01470	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
U064_RS01485	COG0255	Belongs to the universal ribosomal protein uL29 family
U064_RS01540	COG0201	protein transport
U064_RS01545	COG0024	Methionine aminopeptidase
U064_RS01550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
U064_RS01575	COG0202	RNA polymerase activity
U064_RS01595	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
U064_RS01600	COG2353	YceI-like domain
U064_RS01610	COG0859	PFAM glycosyl transferase family 9
U064_RS01620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
U064_RS01625	COG0512	Glutamine amidotransferase of anthranilate synthase
U064_RS01630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
U064_RS01635	COG0135	phosphoribosylanthranilate isomerase activity
U064_RS01635	COG0134	indole-3-glycerol-phosphate synthase activity
U064_RS01640	COG0133	tryptophan synthase activity
U064_RS01645	COG0159	tryptophan synthase activity
U064_RS01655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
U064_RS01665	COG1007	ATP synthesis coupled electron transport
U064_RS01675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
U064_RS01685	COG0839	Belongs to the complex I subunit 6 family
U064_RS01730	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
U064_RS01735	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
U064_RS01750	COG0233	cytoplasmic translational termination
U064_RS01755	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
U064_RS01765	COG0180	Tryptophanyl-tRNA synthetase
U064_RS01770	COG4166	transmembrane transport
U064_RS01775	COG4174	ABC transporter (Permease)
U064_RS01795	COG1466	dna polymerase III delta subunit
U064_RS01800	COG0360	Binds together with S18 to 16S ribosomal RNA
U064_RS01805	COG0629	single-stranded DNA binding
U064_RS01835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
U064_RS01840	COG0424	maF-like protein
U064_RS01850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
U064_RS01910	COG3041	Addiction module toxin RelE StbE family
U064_RS01935	COG1192	Involved in chromosome partitioning
U064_RS02000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
U064_RS02005	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
U064_RS02005	COG0506	proline dehydrogenase activity
U064_RS02005	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
U064_RS02070	COG0830	nickel cation binding
U064_RS02100	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
U064_RS02105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
U064_RS02135	COG0840	transmembrane signaling receptor activity
U064_RS02155	COG0579	oxidoreductase
U064_RS02165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
U064_RS02170	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
U064_RS02175	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
U064_RS02210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
U064_RS02220	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
U064_RS02225	COG0840	transmembrane signaling receptor activity
U064_RS02230	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
U064_RS02240	COG1216	Glycosyl transferase, family 2
U064_RS02250	COG0737	Belongs to the 5'-nucleotidase family
U064_RS02260	COG0626	cystathionine gamma-synthase activity
U064_RS02265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
U064_RS02280	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
U064_RS02285	COG1420	regulation of RNA biosynthetic process
U064_RS02305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
U064_RS02310	COG0551	DNA topoisomerase type I activity
U064_RS02310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
U064_RS02315	COG0731	radical SAM domain protein
U064_RS02330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
U064_RS02330	COG0574	Belongs to the PEP-utilizing enzyme family
U064_RS02345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
U064_RS02355	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
U064_RS02380	COG1760	l-serine dehydratase
U064_RS02385	COG0814	amino acid
U064_RS02390	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
U064_RS02400	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
U064_RS02410	COG1139	Iron-sulfur cluster binding protein
U064_RS02415	COG0247	lactate metabolic process
U064_RS02420	COG1620	l-lactate permease
U064_RS02425	COG1620	l-lactate permease
U064_RS02430	COG1194	a g-specific adenine glycosylase
U064_RS02435	COG0471	metal ion transport
U064_RS02440	COG3278	Belongs to the heme-copper respiratory oxidase family
U064_RS02490	COG0148	phosphopyruvate hydratase activity
U064_RS02520	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
U064_RS02530	COG0217	transcriptional regulatory protein
U064_RS02535	COG0113	porphobilinogen synthase activity
U064_RS02540	COG0642	Histidine kinase
U064_RS02545	COG0745	RESPONSE REGULATOR receiver
U064_RS02560	COG0826	peptidase U32
U064_RS02575	COG0303	'Molybdopterin
U064_RS02590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
U064_RS02595	COG0191	fructose-bisphosphate aldolase activity
U064_RS02605	COG0270	DNA (cytosine-5-)-methyltransferase activity
U064_RS02630	COG2089	acid synthase
U064_RS02635	COG1136	(ABC) transporter
U064_RS02640	COG0815	Transfers the fatty acyl group on membrane lipoproteins
U064_RS02650	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
U064_RS02655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
U064_RS02690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
U064_RS02695	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
U064_RS02700	COG1053	succinate dehydrogenase
U064_RS02710	COG0149	triose-phosphate isomerase activity
U064_RS02715	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
U064_RS02720	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
U064_RS02745	COG0416	fatty acid biosynthetic process
U064_RS02750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
U064_RS02770	COG0489	protein tyrosine kinase activity
U064_RS02790	COG0326	Molecular chaperone. Has ATPase activity
U064_RS02795	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
U064_RS02805	COG0445	tRNA wobble uridine modification
U064_RS02810	COG0471	metal ion transport
U064_RS02815	COG0575	Belongs to the CDS family
U064_RS02835	COG1881	PFAM PEBP family protein
U064_RS02860	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
U064_RS02865	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
U064_RS02865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
U064_RS02875	COG0730	response to heat
U064_RS02885	COG0659	secondary active sulfate transmembrane transporter activity
U064_RS02915	COG0754	glutathionylspermidine amidase activity
U064_RS02925	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
U064_RS02940	COG0442	prolyl-tRNA aminoacylation
U064_RS02965	COG0783	Belongs to the Dps family
U064_RS02970	COG0642	Histidine kinase
U064_RS02975	COG3951	Flagellar rod assembly protein muramidase FlgJ
U064_RS02980	COG1706	bacterial-type flagellum-dependent cell motility
U064_RS03000	COG4172	Belongs to the ABC transporter superfamily
U064_RS03005	COG4239	(ABC) transporter, permease
U064_RS03025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
U064_RS03040	COG0750	zinc metalloprotease
U064_RS03045	COG1570	exodeoxyribonuclease VII activity
U064_RS03060	COG0542	response to heat
U064_RS03065	COG0785	Cytochrome C biogenesis protein
U064_RS03070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
U064_RS03075	COG0402	S-adenosylhomocysteine deaminase activity
U064_RS03110	COG0727	PFAM Uncharacterised protein family (UPF0153)
U064_RS03120	COG0134	indole-3-glycerol-phosphate synthase activity
U064_RS03130	COG0248	Ppx GppA phosphatase
U064_RS03135	COG0859	PFAM glycosyl transferase family 9
U064_RS03165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
U064_RS03170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
U064_RS03190	COG0019	diaminopimelate decarboxylase activity
U064_RS03205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
U064_RS03230	COG0747	negative chemotaxis
U064_RS03235	COG0601	transmembrane transport
U064_RS03240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U064_RS03245	COG0444	Belongs to the ABC transporter superfamily
U064_RS03250	COG4608	Belongs to the ABC transporter superfamily
U064_RS03285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
U064_RS03290	COG0726	polysaccharide deacetylase
U064_RS03310	COG0523	cobalamin synthesis protein
U064_RS03335	COG0748	coenzyme F420 binding
U064_RS03345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
U064_RS03370	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
U064_RS03375	COG3980	spore coat polysaccharide biosynthesis protein
U064_RS03380	COG3980	spore coat polysaccharide biosynthesis protein
U064_RS03385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U064_RS03395	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
U064_RS03405	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
U064_RS03410	COG2894	cell division
U064_RS03420	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
U064_RS03420	COG0758	DNA mediated transformation
U064_RS03425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
U064_RS03430	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
U064_RS03460	COG0668	transmembrane transport
U064_RS03490	COG0750	zinc metalloprotease
U064_RS03500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
U064_RS03505	COG0849	cell division
U064_RS03515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
U064_RS03525	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
U064_RS03585	COG0752	glycyl-tRNA synthetase alpha subunit
U064_RS03590	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
U064_RS03600	COG1519	Transferase
U064_RS03600	COG0220	tRNA (guanine-N7-)-methyltransferase activity
U064_RS03605	COG0564	pseudouridine synthase activity
U064_RS03625	COG1546	Belongs to the CinA family
U064_RS03625	COG1058	Belongs to the CinA family
U064_RS03635	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
U064_RS03655	COG1757	Na H antiporter
U064_RS03685	COG0251	oxidation-reduction process
U064_RS03690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
U064_RS03695	COG1115	amino acid carrier protein
U064_RS03705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U064_RS03710	COG0765	amino acid transport
U064_RS03720	COG0477	Major facilitator Superfamily
U064_RS03735	COG0602	queuosine metabolic process
U064_RS03740	COG0720	synthase
U064_RS03755	COG0142	geranyltranstransferase activity
U064_RS03765	COG0501	Belongs to the peptidase M48B family
U064_RS03780	COG1942	4-Oxalocrotonate Tautomerase
U064_RS03795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
U064_RS03800	COG0670	Belongs to the BI1 family
U064_RS03805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
U064_RS03855	COG1749	Flagellar hook protein flgE
U064_RS03855	COG1749	Flagellar hook protein flgE
U064_RS03860	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
U064_RS03890	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
U064_RS03895	COG0298	carbon dioxide binding
U064_RS03900	COG0409	Hydrogenase expression formation protein
U064_RS03935	COG1607	acyl-coa hydrolase
U064_RS03940	COG0300	oxidoreductase activity
U064_RS03945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U064_RS03950	COG1120	ATPase activity
U064_RS03965	COG0215	cysteine-tRNA ligase activity
U064_RS03970	COG0728	peptidoglycan biosynthetic process
U064_RS04020	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
U064_RS04030	COG0824	Thioesterase
U064_RS04035	COG0733	neurotransmitter:sodium symporter activity
U064_RS04040	COG0733	neurotransmitter:sodium symporter activity
U064_RS04050	COG0592	DNA-directed DNA polymerase activity
U064_RS04055	COG0187	DNA topoisomerase II activity
U064_RS04070	COG1196	nuclear chromosome segregation
U064_RS04070	COG0739	heme binding
U064_RS04070	COG0741	lytic transglycosylase activity
U064_RS04085	COG0277	FAD linked oxidase domain protein
U064_RS04100	COG0174	glutamine synthetase
U064_RS04105	COG3586	endonuclease activity
U064_RS04110	COG0359	binds to the 23S rRNA
U064_RS04265	COG3451	type IV secretory pathway VirB4
U064_RS04290	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
U064_RS04295	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
U064_RS04305	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
U064_RS04310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
U064_RS04340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
U064_RS04350	COG1028	Short-chain dehydrogenase reductase Sdr
U064_RS04375	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
U064_RS04380	COG0628	permease
U064_RS04395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
U064_RS04415	COG0698	ribose 5-phosphate isomerase
U064_RS04420	COG1994	Peptidase M50
U064_RS04425	COG0681	Belongs to the peptidase S26 family
U064_RS04465	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
U064_RS04465	COG1776	CheC inhibitor of MCP methylation
U064_RS04470	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
U064_RS04475	COG1918	ferrous iron import across plasma membrane
U064_RS04495	COG0674	pyruvate-flavodoxin oxidoreductase activity
U064_RS04495	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
U064_RS04500	COG1013	pyruvate-flavodoxin oxidoreductase activity
U064_RS04535	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
U064_RS04540	COG0156	8-amino-7-oxononanoate synthase activity
U064_RS04545	COG0840	transmembrane signaling receptor activity
U064_RS04555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
U064_RS04595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
U064_RS04605	COG1131	(ABC) transporter
U064_RS04620	COG0784	Response regulator, receiver
U064_RS04620	COG0835	chemotaxis
U064_RS04625	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
U064_RS04640	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
U064_RS04645	COG1193	negative regulation of DNA recombination
U064_RS04660	COG0436	Aminotransferase
U064_RS04670	COG2171	N-acyltransferase activity
U064_RS04685	COG2249	NAD(P)H dehydrogenase (quinone) activity
U064_RS04690	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
U064_RS04695	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
U064_RS04700	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
U064_RS04705	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
U064_RS04710	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
U064_RS04735	COG0617	tRNA 3'-terminal CCA addition
U064_RS04745	COG2084	Dehydrogenase
U064_RS04750	COG0778	Nitroreductase
U064_RS04760	COG0762	integral membrane protein
U064_RS04785	COG1027	Aspartate ammonia-lyase
U064_RS04800	COG0560	Phosphoserine phosphatase
U064_RS04805	COG1528	Iron-storage protein
U064_RS04810	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
U064_RS04815	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U064_RS04820	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
U064_RS04830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
U064_RS04845	COG0328	RNA-DNA hybrid ribonuclease activity
U064_RS04850	COG0571	ribonuclease III activity
U064_RS04855	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
U064_RS04865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
U064_RS04910	COG4974	Belongs to the 'phage' integrase family
U064_RS04920	COG0730	response to heat
U064_RS04930	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
U064_RS04965	COG1338	Plays a role in the flagellum-specific transport system
U064_RS04975	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
U064_RS04985	COG0183	Belongs to the thiolase family
U064_RS04990	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
U064_RS04995	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
U064_RS05000	COG2031	fatty acid transporter
U064_RS05010	COG0145	ligase activity
U064_RS05015	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
U064_RS05020	COG4647	ligase activity
U064_RS05035	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
U064_RS05040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
U064_RS05050	COG2204	response regulator
U064_RS05070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
U064_RS05090	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
U064_RS05105	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
U064_RS05110	COG1137	ATPase activity
U064_RS05120	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
U064_RS05125	COG1279	arginine transmembrane transporter activity
U064_RS05145	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
U064_RS05150	COG0252	asparaginase activity
U064_RS05165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
U064_RS05170	COG0037	tRNA processing
U064_RS05200	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
U064_RS05205	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
U064_RS05210	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
U064_RS05215	COG1181	Belongs to the D-alanine--D-alanine ligase family
U064_RS05225	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
U064_RS05235	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
U064_RS05250	COG0564	pseudouridine synthase activity
U064_RS05260	COG0220	tRNA (guanine-N7-)-methyltransferase activity
U064_RS05265	COG2884	Cell division ATP-binding protein ftsE
U064_RS05285	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
U064_RS05315	COG2056	Na+-H+ antiporter family
U064_RS05320	COG0534	Mate efflux family protein
U064_RS05325	COG1418	mRNA catabolic process
U064_RS05340	COG0552	protein localization to endoplasmic reticulum
U064_RS05365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
U064_RS05375	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
U064_RS05385	COG0860	N-Acetylmuramoyl-L-alanine amidase
U064_RS05390	COG0126	phosphoglycerate kinase activity
U064_RS05395	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
U064_RS05400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
U064_RS05405	COG1758	RNA polymerase activity
U064_RS05420	COG1049	propionate catabolic process, 2-methylcitrate cycle
U064_RS05455	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
U064_RS05480	COG2217	Heavy metal translocating P-type atpase
U064_RS05485	COG0606	chelatase, subunit chli
U064_RS05515	COG0315	cyclic pyranopterin monophosphate synthase activity
U064_RS05520	COG0521	Mo-molybdopterin cofactor biosynthetic process
U064_RS05525	COG0314	molybdopterin synthase activity
U064_RS05545	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
U064_RS05545	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
U064_RS05565	COG0736	holo-[acyl-carrier-protein] synthase activity
U064_RS05570	COG1580	Controls the rotational direction of flagella during chemotaxis
U064_RS05595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
U064_RS05600	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
U064_RS05605	COG1360	Flagellar Motor Protein
U064_RS05615	COG1732	Glycine betaine
U064_RS05620	COG0517	IMP dehydrogenase activity
U064_RS05620	COG1125	glycine betaine transport
U064_RS05635	COG0322	excinuclease ABC activity
U064_RS05640	COG0460	homoserine dehydrogenase
U064_RS05650	COG3118	belongs to the thioredoxin family
U064_RS05655	COG0492	ferredoxin-NADP+ reductase activity
U064_RS05665	COG0724	RNA recognition motif
U064_RS05675	COG0517	IMP dehydrogenase activity
U064_RS05675	COG0516	GMP reductase activity
U064_RS05685	COG0237	dephospho-CoA kinase activity
U064_RS05690	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
U064_RS05705	COG0776	regulation of translation
U064_RS05730	COG1086	Polysaccharide biosynthesis protein
U064_RS05735	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
U064_RS05745	COG0352	thiamine-phosphate diphosphorylase activity
U064_RS05750	COG0351	phosphomethylpyrimidine kinase
U064_RS05780	COG0671	phosphoesterase, PA-phosphatase related
U064_RS05790	COG0488	(ABC) transporter
U064_RS05795	COG0516	GMP reductase activity
U064_RS05800	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
U064_RS05805	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
U064_RS05805	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
U064_RS05810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
U064_RS05815	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
U064_RS05825	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
U064_RS05840	COG0756	dUTP diphosphatase activity
U064_RS05860	COG0375	protein maturation
U064_RS05865	COG1749	Flagellar hook protein flgE
U064_RS05870	COG2134	cdp-diacylglycerol pyrophosphatase
U064_RS05875	COG2824	Alkylphosphonate utilization operon protein PhnA
U064_RS05890	COG0753	catalase activity
U064_RS05900	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
U064_RS05955	COG1217	gtp-binding protein TYPA
U064_RS05980	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
U064_RS06035	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
U064_RS06050	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
U064_RS06070	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
U064_RS06085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
U064_RS06090	COG1028	Short-chain dehydrogenase reductase Sdr
U064_RS06100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
U064_RS06105	COG0833	amino acid
U064_RS06115	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
U064_RS06115	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
U064_RS06120	COG0745	RESPONSE REGULATOR receiver
U064_RS06135	COG0484	heat shock protein binding
U064_RS06140	COG0789	Transcriptional regulator
U064_RS06145	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
U064_RS06145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
U064_RS06150	COG0735	belongs to the Fur family
U064_RS06165	COG1776	CheC inhibitor of MCP methylation
U064_RS06165	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
U064_RS06170	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
U064_RS06185	COG0455	bacterial-type flagellum organization
U064_RS06190	COG1419	protein localization to endoplasmic reticulum
U064_RS06195	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
U064_RS06200	COG0006	proline dipeptidase activity
U064_RS06220	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
U064_RS06225	COG2404	hydrolase activity, acting on ester bonds
U064_RS06230	COG0745	RESPONSE REGULATOR receiver
U064_RS06235	COG1408	metallophosphoesterase
U064_RS06245	COG0779	Required for maturation of 30S ribosomal subunits
U064_RS06250	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
U064_RS06265	COG0083	homoserine kinase activity
U064_RS06320	COG0805	protein transport
U064_RS06330	COG0357	Ribosomal RNA small subunit methyltransferase G
U064_RS06355	COG0745	RESPONSE REGULATOR receiver
U064_RS06365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
U064_RS06375	COG1183	phosphatidylcholine synthase activity
U064_RS06380	COG2217	Heavy metal translocating P-type atpase
U064_RS06385	COG2608	mercury ion transmembrane transporter activity
U064_RS06400	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
U064_RS06410	COG1106	Psort location Cytoplasmic, score
U064_RS06425	COG1132	(ABC) transporter
U064_RS06445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
U064_RS06450	COG0196	riboflavin kinase activity
U064_RS06455	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
U064_RS06465	COG1674	ftsk spoiiie
U064_RS06470	COG0477	Major facilitator Superfamily
U064_RS06475	COG4786	Flagellar basal body rod
U064_RS06500	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
U064_RS06510	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
U064_RS06515	COG1766	The M ring may be actively involved in energy transduction
U064_RS06525	COG0504	CTP synthase activity
U064_RS06530	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
U064_RS06530	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
U064_RS06535	COG0564	pseudouridine synthase activity
U064_RS06635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
U064_RS06640	COG3451	type IV secretory pathway VirB4
U064_RS06710	COG1166	arginine decarboxylase activity
U064_RS06725	COG0500	methyltransferase
U064_RS06735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U064_RS06735	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U064_RS06740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
U064_RS06745	COG0668	transmembrane transport
U064_RS06805	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
U064_RS06810	COG0537	adenosine 5'-monophosphoramidase activity
U064_RS06820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U064_RS06820	COG0072	phenylalanine-tRNA ligase activity
U064_RS06835	COG0539	negative regulation of cytoplasmic translation
U064_RS06835	COG1185	polyribonucleotide nucleotidyltransferase activity
U064_RS06845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
U064_RS06850	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
U064_RS06855	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
U064_RS06865	COG0835	chemotaxis
U064_RS06865	COG0784	Response regulator, receiver
U064_RS06870	COG0784	Response regulator, receiver
U064_RS06870	COG2198	Histidine kinase
U064_RS06870	COG0643	Histidine kinase
U064_RS06875	COG0835	chemotaxis
U064_RS06880	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
U064_RS06885	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
U064_RS06890	COG2226	methyltransferase
U064_RS06895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
U064_RS06920	COG0501	Belongs to the peptidase M48B family
U064_RS06925	COG2890	protein-(glutamine-N5) methyltransferase activity
U064_RS06930	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
U064_RS06940	COG1333	cytochrome c biogenesis protein
U064_RS06940	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
U064_RS06960	COG1385	rRNA (uridine-N3-)-methyltransferase activity
U064_RS06975	COG0511	ligase activity, forming carbon-carbon bonds
U064_RS06980	COG0439	Biotin carboxylase
U064_RS07010	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
U064_RS07020	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
U064_RS07025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
U064_RS07035	COG0101	tRNA pseudouridine synthase activity
U064_RS07060	COG4221	oxidoreductase activity
U064_RS07065	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
U064_RS07070	COG0800	Aldolase
U064_RS07075	COG0129	dihydroxy-acid dehydratase activity
U064_RS07080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
U064_RS07085	COG0363	glucosamine-6-phosphate deaminase activity
U064_RS07095	COG1064	alcohol dehydrogenase
U064_RS07120	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
U064_RS07130	COG0674	pyruvate-flavodoxin oxidoreductase activity
U064_RS07135	COG1013	pyruvate-flavodoxin oxidoreductase activity
U064_RS07140	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
U064_RS07175	COG0405	Gamma-glutamyltransferase
U064_RS07205	COG1047	Peptidyl-prolyl cis-trans
U064_RS07215	COG2885	chlorophyll binding
U064_RS07220	COG0823	Involved in the tonB-independent uptake of proteins
U064_RS07230	COG0848	biopolymer transport protein
U064_RS07235	COG0811	peptide transport
U064_RS07275	COG1475	DNA binding
U064_RS07280	COG1192	Involved in chromosome partitioning
U064_RS07285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
U064_RS07285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
U064_RS07290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
U064_RS07320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
U064_RS07330	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
U064_RS07340	COG0811	peptide transport
U064_RS07345	COG0848	biopolymer transport protein
U064_RS07365	COG0706	membrane insertase activity
U064_RS07375	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
U064_RS07415	COG1187	pseudouridine synthase activity
U064_RS07420	COG0587	DNA-directed DNA polymerase activity
U064_RS07445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
U064_RS07450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
U064_RS07460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
U064_RS07470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
U064_RS07470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
U064_RS07490	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
U064_RS07500	COG0163	prenyltransferase activity
U064_RS07535	COG2226	methyltransferase
U064_RS07540	COG1981	membrane
U064_RS07545	COG1739	Uncharacterized protein family UPF0029
U064_RS07560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U064_RS07570	COG1253	flavin adenine dinucleotide binding
U064_RS07575	COG0306	phosphate transporter
U064_RS07580	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
U064_RS07590	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
U064_RS07595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
U064_RS07605	COG0193	aminoacyl-tRNA hydrolase activity
U064_RS07635	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
U064_RS07645	COG0786	glutamate:sodium symporter activity
U064_RS07655	COG0348	domain, Protein
U064_RS07660	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
U064_RS07680	COG1921	L-seryl-tRNASec selenium transferase activity
U064_RS07685	COG0195	Participates in both transcription termination and antitermination
U064_RS07690	COG1687	branched-chain amino acid
U064_RS07720	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
U064_RS07735	COG0708	Exodeoxyribonuclease III
U064_RS07770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
U064_RS07775	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
U064_RS07805	COG0010	Belongs to the arginase family
U064_RS07810	COG0686	Belongs to the AlaDH PNT family
U064_RS07830	COG0497	DNA recombination
U064_RS07870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
U064_RS07905	COG1074	ATP-dependent DNA helicase activity
U064_RS07910	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
U064_RS07915	COG1862	Preprotein translocase
U064_RS07920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
U064_RS07925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
U064_RS07935	COG0495	leucyl-tRNA aminoacylation
U064_RS07945	COG0285	dihydrofolate synthase activity
U064_RS07955	COG0739	heme binding
U064_RS07965	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
U064_RS07970	COG0723	plastoquinol--plastocyanin reductase activity
U064_RS07990	COG1106	Psort location Cytoplasmic, score
U064_RS07995	COG0768	penicillin binding
U064_RS08005	COG1558	bacterial-type flagellum-dependent cell motility
U064_RS08010	COG1815	bacterial-type flagellum-dependent cell motility
U064_RS08015	COG0772	Belongs to the SEDS family
U064_RS08030	COG0450	alkyl hydroperoxide reductase
U064_RS08040	COG0768	penicillin binding
U064_RS08065	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
U064_RS08070	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
U064_RS08075	COG0741	lytic transglycosylase activity
U064_RS08075	COG1388	LysM domain
U064_RS08080	COG0084	hydrolase, TatD family'
U064_RS08085	COG0307	riboflavin synthase, alpha
U064_RS08095	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
U064_RS08100	COG2011	ABC-type metal ion transport system permease component
U064_RS08115	COG0671	phosphoesterase, PA-phosphatase related
U064_RS08120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
U064_RS08140	COG4786	Flagellar basal body rod
U064_RS08160	COG4735	regulation of single-species biofilm formation