locus-tag	class	description
EE66_RS00005	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EE66_RS00010	COG0848	biopolymer transport protein
EE66_RS00015	COG0811	peptide transport
EE66_RS00045	COG0484	heat shock protein binding
EE66_RS00050	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EE66_RS00055	COG1687	branched-chain amino acid
EE66_RS00060	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EE66_RS00065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EE66_RS00080	COG0114	fumarate hydratase activity
EE66_RS00110	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EE66_RS00135	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EE66_RS00150	COG0255	Belongs to the universal ribosomal protein uL29 family
EE66_RS00170	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EE66_RS00205	COG0201	protein transport
EE66_RS00210	COG0024	Methionine aminopeptidase
EE66_RS00215	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EE66_RS00235	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EE66_RS00240	COG0202	RNA polymerase activity
EE66_RS00260	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EE66_RS00265	COG2353	YceI-like domain
EE66_RS00275	COG0859	PFAM glycosyl transferase family 9
EE66_RS00280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EE66_RS00285	COG0512	Glutamine amidotransferase of anthranilate synthase
EE66_RS00290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EE66_RS00295	COG0134	indole-3-glycerol-phosphate synthase activity
EE66_RS00295	COG0135	phosphoribosylanthranilate isomerase activity
EE66_RS00300	COG0133	tryptophan synthase activity
EE66_RS00325	COG1007	ATP synthesis coupled electron transport
EE66_RS00335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EE66_RS00340	COG0713	ATP synthesis coupled electron transport
EE66_RS00345	COG0839	Belongs to the complex I subunit 6 family
EE66_RS00380	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EE66_RS00390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EE66_RS00395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EE66_RS00415	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EE66_RS00425	COG0180	Tryptophanyl-tRNA synthetase
EE66_RS00430	COG4166	transmembrane transport
EE66_RS00435	COG4174	ABC transporter (Permease)
EE66_RS00450	COG0557	exoribonuclease II activity
EE66_RS00455	COG1466	dna polymerase III delta subunit
EE66_RS00465	COG0629	single-stranded DNA binding
EE66_RS00490	COG0424	maF-like protein
EE66_RS00510	COG0505	Belongs to the CarA family
EE66_RS00525	COG0697	spore germination
EE66_RS00540	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EE66_RS00555	COG0527	aspartate kinase activity
EE66_RS00565	COG2863	cytochrome
EE66_RS00570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EE66_RS00595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EE66_RS00600	COG1131	(ABC) transporter
EE66_RS00610	COG0151	Belongs to the GarS family
EE66_RS00620	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EE66_RS00650	COG1045	serine acetyltransferase
EE66_RS00670	COG1132	(ABC) transporter
EE66_RS00715	COG0250	Participates in transcription elongation, termination and antitermination
EE66_RS00770	COG0859	PFAM glycosyl transferase family 9
EE66_RS00780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EE66_RS00795	COG2814	Major facilitator Superfamily
EE66_RS00805	COG0475	glutathione-regulated potassium exporter activity
EE66_RS00805	COG0569	domain protein
EE66_RS00810	COG0037	tRNA processing
EE66_RS00815	COG2814	Major facilitator Superfamily
EE66_RS00825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EE66_RS00850	COG2252	PERMEase
EE66_RS00855	COG0738	Major facilitator superfamily
EE66_RS00870	COG1126	abc transporter atp-binding protein
EE66_RS00875	COG0765	amino acid transport
EE66_RS00885	COG1966	Carbon starvation protein
EE66_RS00895	COG0166	Belongs to the GPI family
EE66_RS00920	COG0716	FMN binding
EE66_RS00930	COG2184	nucleotidyltransferase activity
EE66_RS00935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EE66_RS00950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EE66_RS00960	COG0525	valine-tRNA ligase activity
EE66_RS00965	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EE66_RS00985	COG0336	Belongs to the RNA methyltransferase TrmD family
EE66_RS01015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EE66_RS01020	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EE66_RS01020	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EE66_RS01025	COG1192	Involved in chromosome partitioning
EE66_RS01030	COG1475	DNA binding
EE66_RS01060	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EE66_RS01070	COG0811	peptide transport
EE66_RS01075	COG0848	biopolymer transport protein
EE66_RS01085	COG0823	Involved in the tonB-independent uptake of proteins
EE66_RS01090	COG2885	chlorophyll binding
EE66_RS01100	COG1047	Peptidyl-prolyl cis-trans
EE66_RS01130	COG0405	Gamma-glutamyltransferase
EE66_RS01145	COG0556	nucleotide-excision repair
EE66_RS01155	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EE66_RS01160	COG1013	pyruvate-flavodoxin oxidoreductase activity
EE66_RS01165	COG0674	pyruvate-flavodoxin oxidoreductase activity
EE66_RS01175	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EE66_RS01195	COG1064	alcohol dehydrogenase
EE66_RS01205	COG0363	glucosamine-6-phosphate deaminase activity
EE66_RS01210	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EE66_RS01215	COG0129	dihydroxy-acid dehydratase activity
EE66_RS01220	COG0800	Aldolase
EE66_RS01225	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EE66_RS01230	COG4221	oxidoreductase activity
EE66_RS01265	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EE66_RS01270	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EE66_RS01280	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EE66_RS01300	COG0439	Biotin carboxylase
EE66_RS01305	COG0511	ligase activity, forming carbon-carbon bonds
EE66_RS01320	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EE66_RS01340	COG1333	cytochrome c biogenesis protein
EE66_RS01340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EE66_RS01350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EE66_RS01355	COG2890	protein-(glutamine-N5) methyltransferase activity
EE66_RS01360	COG0501	Belongs to the peptidase M48B family
EE66_RS01385	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EE66_RS01395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EE66_RS01400	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EE66_RS01405	COG0835	chemotaxis
EE66_RS01410	COG2198	Histidine kinase
EE66_RS01410	COG0784	Response regulator, receiver
EE66_RS01410	COG0643	Histidine kinase
EE66_RS01415	COG0784	Response regulator, receiver
EE66_RS01415	COG0835	chemotaxis
EE66_RS01425	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EE66_RS01430	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EE66_RS01435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EE66_RS01445	COG1185	polyribonucleotide nucleotidyltransferase activity
EE66_RS01445	COG0539	negative regulation of cytoplasmic translation
EE66_RS01460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EE66_RS01460	COG0072	phenylalanine-tRNA ligase activity
EE66_RS01470	COG0537	adenosine 5'-monophosphoramidase activity
EE66_RS01475	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EE66_RS01535	COG0668	transmembrane transport
EE66_RS01540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EE66_RS01545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EE66_RS01545	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EE66_RS01570	COG1166	arginine decarboxylase activity
EE66_RS01580	COG0668	transmembrane transport
EE66_RS01585	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EE66_RS01590	COG0849	cell division
EE66_RS01600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EE66_RS01605	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EE66_RS01610	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EE66_RS01645	COG3309	Virulence-associated protein D
EE66_RS01685	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EE66_RS01695	COG1519	Transferase
EE66_RS01700	COG0564	pseudouridine synthase activity
EE66_RS01720	COG1546	Belongs to the CinA family
EE66_RS01720	COG1058	Belongs to the CinA family
EE66_RS01730	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EE66_RS01750	COG1757	Na H antiporter
EE66_RS01780	COG0251	oxidation-reduction process
EE66_RS01785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EE66_RS01790	COG1115	amino acid carrier protein
EE66_RS01800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EE66_RS01805	COG0765	amino acid transport
EE66_RS01835	COG0602	queuosine metabolic process
EE66_RS01840	COG0720	synthase
EE66_RS01855	COG0142	geranyltranstransferase activity
EE66_RS01880	COG1942	4-Oxalocrotonate Tautomerase
EE66_RS01890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EE66_RS01895	COG0670	Belongs to the BI1 family
EE66_RS01900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EE66_RS01945	COG1749	Flagellar hook protein flgE
EE66_RS01945	COG1749	Flagellar hook protein flgE
EE66_RS01950	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EE66_RS01960	COG0280	phosphate acetyltransferase
EE66_RS01985	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EE66_RS01990	COG0298	carbon dioxide binding
EE66_RS01995	COG0409	Hydrogenase expression formation protein
EE66_RS02030	COG1607	acyl-coa hydrolase
EE66_RS02035	COG0300	oxidoreductase activity
EE66_RS02040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EE66_RS02045	COG1120	ATPase activity
EE66_RS02060	COG0728	peptidoglycan biosynthetic process
EE66_RS02100	COG0753	catalase activity
EE66_RS02115	COG2824	Alkylphosphonate utilization operon protein PhnA
EE66_RS02125	COG2134	cdp-diacylglycerol pyrophosphatase
EE66_RS02130	COG1749	Flagellar hook protein flgE
EE66_RS02135	COG0375	protein maturation
EE66_RS02150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EE66_RS02155	COG0756	dUTP diphosphatase activity
EE66_RS02170	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EE66_RS02180	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EE66_RS02185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EE66_RS02205	COG0488	(ABC) transporter
EE66_RS02215	COG0671	phosphoesterase, PA-phosphatase related
EE66_RS02245	COG0351	phosphomethylpyrimidine kinase
EE66_RS02260	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EE66_RS02265	COG1086	Polysaccharide biosynthesis protein
EE66_RS02290	COG0776	regulation of translation
EE66_RS02310	COG0237	dephospho-CoA kinase activity
EE66_RS02320	COG0517	IMP dehydrogenase activity
EE66_RS02320	COG0516	GMP reductase activity
EE66_RS02330	COG0724	RNA recognition motif
EE66_RS02340	COG0492	ferredoxin-NADP+ reductase activity
EE66_RS02345	COG3118	belongs to the thioredoxin family
EE66_RS02355	COG0460	homoserine dehydrogenase
EE66_RS02375	COG1125	glycine betaine transport
EE66_RS02375	COG0517	IMP dehydrogenase activity
EE66_RS02380	COG1732	Glycine betaine
EE66_RS02390	COG1360	Flagellar Motor Protein
EE66_RS02395	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EE66_RS02400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EE66_RS02405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EE66_RS02425	COG1580	Controls the rotational direction of flagella during chemotaxis
EE66_RS02430	COG0736	holo-[acyl-carrier-protein] synthase activity
EE66_RS02460	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EE66_RS02460	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EE66_RS02480	COG0314	molybdopterin synthase activity
EE66_RS02485	COG0521	Mo-molybdopterin cofactor biosynthetic process
EE66_RS02520	COG0606	chelatase, subunit chli
EE66_RS02525	COG2217	Heavy metal translocating P-type atpase
EE66_RS02585	COG1049	propionate catabolic process, 2-methylcitrate cycle
EE66_RS02595	COG0528	UMP kinase activity
EE66_RS02600	COG1758	RNA polymerase activity
EE66_RS02605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EE66_RS02610	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EE66_RS02615	COG0126	phosphoglycerate kinase activity
EE66_RS02620	COG0860	N-Acetylmuramoyl-L-alanine amidase
EE66_RS02665	COG0552	protein localization to endoplasmic reticulum
EE66_RS02685	COG0534	Mate efflux family protein
EE66_RS02690	COG2056	Na+-H+ antiporter family
EE66_RS02720	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EE66_RS02740	COG2884	Cell division ATP-binding protein ftsE
EE66_RS02745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EE66_RS02755	COG0564	pseudouridine synthase activity
EE66_RS02765	COG0772	Belongs to the SEDS family
EE66_RS02775	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EE66_RS02785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EE66_RS02800	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EE66_RS02805	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EE66_RS02810	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EE66_RS02845	COG0037	tRNA processing
EE66_RS02850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EE66_RS02865	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EE66_RS02870	COG0252	asparaginase activity
EE66_RS02890	COG1279	arginine transmembrane transporter activity
EE66_RS02895	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EE66_RS02905	COG1137	ATPase activity
EE66_RS02910	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EE66_RS02920	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
EE66_RS02940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EE66_RS02945	COG2204	response regulator
EE66_RS02955	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EE66_RS02960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EE66_RS02975	COG4647	ligase activity
EE66_RS02980	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
EE66_RS02985	COG0145	ligase activity
EE66_RS02995	COG2031	fatty acid transporter
EE66_RS03000	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EE66_RS03005	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EE66_RS03010	COG0183	Belongs to the thiolase family
EE66_RS03020	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EE66_RS03030	COG1338	Plays a role in the flagellum-specific transport system
EE66_RS03060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EE66_RS03080	COG4974	Belongs to the 'phage' integrase family
EE66_RS03110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EE66_RS03120	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EE66_RS03125	COG0571	ribonuclease III activity
EE66_RS03145	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EE66_RS03155	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EE66_RS03160	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EE66_RS03165	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EE66_RS03170	COG1528	Iron-storage protein
EE66_RS03175	COG0560	Phosphoserine phosphatase
EE66_RS03190	COG1027	Aspartate ammonia-lyase
EE66_RS03215	COG0762	integral membrane protein
EE66_RS03225	COG0778	Nitroreductase
EE66_RS03230	COG0617	tRNA 3'-terminal CCA addition
EE66_RS03250	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EE66_RS03255	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EE66_RS03260	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
EE66_RS03265	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
EE66_RS03270	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
EE66_RS03275	COG2249	NAD(P)H dehydrogenase (quinone) activity
EE66_RS03290	COG2171	N-acyltransferase activity
EE66_RS03300	COG0436	Aminotransferase
EE66_RS03315	COG1193	negative regulation of DNA recombination
EE66_RS03320	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EE66_RS03335	COG3306	glycosyltransferase involved in LPS biosynthesis
EE66_RS03345	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EE66_RS03350	COG0784	Response regulator, receiver
EE66_RS03350	COG0835	chemotaxis
EE66_RS03365	COG1131	(ABC) transporter
EE66_RS03415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EE66_RS03425	COG0840	transmembrane signaling receptor activity
EE66_RS03430	COG0156	8-amino-7-oxononanoate synthase activity
EE66_RS03435	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EE66_RS03470	COG1013	pyruvate-flavodoxin oxidoreductase activity
EE66_RS03475	COG0674	pyruvate-flavodoxin oxidoreductase activity
EE66_RS03475	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EE66_RS03495	COG1918	ferrous iron import across plasma membrane
EE66_RS03500	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EE66_RS03505	COG1776	CheC inhibitor of MCP methylation
EE66_RS03505	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EE66_RS03545	COG0681	Belongs to the peptidase S26 family
EE66_RS03550	COG1994	Peptidase M50
EE66_RS03555	COG0698	ribose 5-phosphate isomerase
EE66_RS03580	COG0012	GTP binding
EE66_RS03590	COG0628	permease
EE66_RS03620	COG1028	Short-chain dehydrogenase reductase Sdr
EE66_RS03635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EE66_RS03665	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EE66_RS03675	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EE66_RS03690	COG1842	Phage shock protein A
EE66_RS03710	COG3451	type IV secretory pathway VirB4
EE66_RS03875	COG3586	endonuclease activity
EE66_RS03880	COG0174	glutamine synthetase
EE66_RS03895	COG0277	FAD linked oxidase domain protein
EE66_RS03910	COG1196	nuclear chromosome segregation
EE66_RS03910	COG0741	lytic transglycosylase activity
EE66_RS03910	COG0739	heme binding
EE66_RS03930	COG0187	DNA topoisomerase II activity
EE66_RS03935	COG0592	DNA-directed DNA polymerase activity
EE66_RS03945	COG0733	neurotransmitter:sodium symporter activity
EE66_RS03950	COG0733	neurotransmitter:sodium symporter activity
EE66_RS03955	COG0824	Thioesterase
EE66_RS03965	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EE66_RS04040	COG1217	gtp-binding protein TYPA
EE66_RS04135	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EE66_RS04155	COG1028	Short-chain dehydrogenase reductase Sdr
EE66_RS04165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EE66_RS04170	COG0833	amino acid
EE66_RS04185	COG0745	RESPONSE REGULATOR receiver
EE66_RS04200	COG0484	heat shock protein binding
EE66_RS04205	COG0789	Transcriptional regulator
EE66_RS04210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EE66_RS04210	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EE66_RS04215	COG0735	belongs to the Fur family
EE66_RS04230	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EE66_RS04230	COG1776	CheC inhibitor of MCP methylation
EE66_RS04235	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EE66_RS04250	COG0455	bacterial-type flagellum organization
EE66_RS04255	COG1419	protein localization to endoplasmic reticulum
EE66_RS04260	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EE66_RS04265	COG0006	proline dipeptidase activity
EE66_RS04285	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EE66_RS04290	COG2404	hydrolase activity, acting on ester bonds
EE66_RS04295	COG0745	RESPONSE REGULATOR receiver
EE66_RS04300	COG1408	metallophosphoesterase
EE66_RS04330	COG0083	homoserine kinase activity
EE66_RS04340	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EE66_RS04385	COG0805	protein transport
EE66_RS04395	COG0357	Ribosomal RNA small subunit methyltransferase G
EE66_RS04420	COG0745	RESPONSE REGULATOR receiver
EE66_RS04430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EE66_RS04440	COG1183	phosphatidylcholine synthase activity
EE66_RS04445	COG2217	Heavy metal translocating P-type atpase
EE66_RS04450	COG2608	mercury ion transmembrane transporter activity
EE66_RS04470	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
EE66_RS04480	COG1106	Psort location Cytoplasmic, score
EE66_RS04495	COG1132	(ABC) transporter
EE66_RS04515	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EE66_RS04520	COG0196	riboflavin kinase activity
EE66_RS04525	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EE66_RS04535	COG1674	ftsk spoiiie
EE66_RS04540	COG0477	Major facilitator Superfamily
EE66_RS04545	COG4786	Flagellar basal body rod
EE66_RS04560	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EE66_RS04570	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EE66_RS04575	COG1766	The M ring may be actively involved in energy transduction
EE66_RS04585	COG0504	CTP synthase activity
EE66_RS04590	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EE66_RS04590	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EE66_RS04595	COG0564	pseudouridine synthase activity
EE66_RS04645	COG0758	DNA mediated transformation
EE66_RS04645	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EE66_RS04655	COG2894	cell division
EE66_RS04675	COG1663	tetraacyldisaccharide 4'-kinase activity
EE66_RS04680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EE66_RS04685	COG3980	spore coat polysaccharide biosynthesis protein
EE66_RS04690	COG3980	spore coat polysaccharide biosynthesis protein
EE66_RS04695	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EE66_RS04730	COG0748	coenzyme F420 binding
EE66_RS04740	COG0523	cobalamin synthesis protein
EE66_RS04760	COG0726	polysaccharide deacetylase
EE66_RS04765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EE66_RS04780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EE66_RS04800	COG4608	Belongs to the ABC transporter superfamily
EE66_RS04805	COG0444	Belongs to the ABC transporter superfamily
EE66_RS04810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EE66_RS04815	COG0601	transmembrane transport
EE66_RS04820	COG0747	negative chemotaxis
EE66_RS04845	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EE66_RS04860	COG0019	diaminopimelate decarboxylase activity
EE66_RS04880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EE66_RS04885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EE66_RS04915	COG0859	PFAM glycosyl transferase family 9
EE66_RS04920	COG0248	Ppx GppA phosphatase
EE66_RS04940	COG0727	PFAM Uncharacterised protein family (UPF0153)
EE66_RS04975	COG0402	S-adenosylhomocysteine deaminase activity
EE66_RS04980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EE66_RS04985	COG0785	Cytochrome C biogenesis protein
EE66_RS04990	COG0542	response to heat
EE66_RS05010	COG0750	zinc metalloprotease
EE66_RS05045	COG4239	(ABC) transporter, permease
EE66_RS05050	COG4172	Belongs to the ABC transporter superfamily
EE66_RS05075	COG3951	Flagellar rod assembly protein muramidase FlgJ
EE66_RS05080	COG0642	Histidine kinase
EE66_RS05085	COG0783	Belongs to the Dps family
EE66_RS05125	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EE66_RS05135	COG0754	glutathionylspermidine amidase activity
EE66_RS05165	COG0659	secondary active sulfate transmembrane transporter activity
EE66_RS05175	COG0730	response to heat
EE66_RS05180	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EE66_RS05180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EE66_RS05185	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EE66_RS05200	COG1104	cysteine desulfurase activity
EE66_RS05210	COG1881	PFAM PEBP family protein
EE66_RS05230	COG0575	Belongs to the CDS family
EE66_RS05235	COG0471	metal ion transport
EE66_RS05255	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EE66_RS05260	COG0326	Molecular chaperone. Has ATPase activity
EE66_RS05280	COG0489	protein tyrosine kinase activity
EE66_RS05295	COG3041	Addiction module toxin RelE StbE family
EE66_RS05310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EE66_RS05330	COG0105	UTP biosynthetic process
EE66_RS05340	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EE66_RS05345	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EE66_RS05360	COG1053	succinate dehydrogenase
EE66_RS05365	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EE66_RS05370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EE66_RS05415	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EE66_RS05420	COG1136	(ABC) transporter
EE66_RS05425	COG2089	acid synthase
EE66_RS05435	COG0191	fructose-bisphosphate aldolase activity
EE66_RS05440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EE66_RS05470	COG0826	peptidase U32
EE66_RS05485	COG0745	RESPONSE REGULATOR receiver
EE66_RS05490	COG0642	Histidine kinase
EE66_RS05495	COG0113	porphobilinogen synthase activity
EE66_RS05505	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EE66_RS05535	COG0148	phosphopyruvate hydratase activity
EE66_RS05585	COG3278	Belongs to the heme-copper respiratory oxidase family
EE66_RS05590	COG0471	metal ion transport
EE66_RS05595	COG1194	a g-specific adenine glycosylase
EE66_RS05600	COG1620	l-lactate permease
EE66_RS05605	COG1620	l-lactate permease
EE66_RS05610	COG0247	lactate metabolic process
EE66_RS05615	COG1139	Iron-sulfur cluster binding protein
EE66_RS05625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EE66_RS05640	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EE66_RS05645	COG0814	amino acid
EE66_RS05650	COG1760	l-serine dehydratase
EE66_RS05685	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EE66_RS05690	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EE66_RS05725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EE66_RS05735	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EE66_RS05740	COG0840	transmembrane signaling receptor activity
EE66_RS05745	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EE66_RS05765	COG0737	Belongs to the 5'-nucleotidase family
EE66_RS05775	COG0626	cystathionine gamma-synthase activity
EE66_RS05780	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EE66_RS05795	COG1420	regulation of RNA biosynthetic process
EE66_RS05815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EE66_RS05820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EE66_RS05820	COG0551	DNA topoisomerase type I activity
EE66_RS05825	COG0731	radical SAM domain protein
EE66_RS05840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EE66_RS05840	COG0574	Belongs to the PEP-utilizing enzyme family
EE66_RS05855	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EE66_RS05890	COG3451	type IV secretory pathway VirB4
EE66_RS05950	COG1192	Involved in chromosome partitioning
EE66_RS05965	COG4974	Belongs to the 'phage' integrase family
EE66_RS06000	COG1192	Involved in chromosome partitioning
EE66_RS06025	COG3041	Addiction module toxin RelE StbE family
EE66_RS06085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EE66_RS06090	COG3451	type IV secretory pathway VirB4
EE66_RS06150	COG3550	peptidyl-serine autophosphorylation
EE66_RS06155	COG4974	Belongs to the 'phage' integrase family
EE66_RS06160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EE66_RS06190	COG0840	transmembrane signaling receptor activity
EE66_RS06215	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EE66_RS06230	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EE66_RS06240	COG0831	urea catabolic process
EE66_RS06240	COG0832	Belongs to the urease beta subunit family
EE66_RS06245	COG0804	urea catabolic process
EE66_RS06260	COG0830	nickel cation binding
EE66_RS06330	COG0506	proline dehydrogenase activity
EE66_RS06330	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EE66_RS06330	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EE66_RS06335	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EE66_RS06360	COG2957	Belongs to the agmatine deiminase family
EE66_RS06365	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EE66_RS06380	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EE66_RS06430	COG0542	response to heat
EE66_RS06435	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EE66_RS06440	COG0589	response to stress
EE66_RS06465	COG0538	isocitrate dehydrogenase activity
EE66_RS06470	COG0372	Belongs to the citrate synthase family
EE66_RS06480	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EE66_RS06495	COG1295	ribonuclease BN
EE66_RS06505	COG0799	negative regulation of ribosome biogenesis
EE66_RS06530	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EE66_RS06535	COG1987	bacterial-type flagellum assembly
EE66_RS06540	COG1157	protein secretion by the type III secretion system
EE66_RS06545	COG4962	Type ii secretion system protein e
EE66_RS06555	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EE66_RS06575	COG0517	IMP dehydrogenase activity
EE66_RS06575	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EE66_RS06580	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EE66_RS06605	COG0788	formyltetrahydrofolate deformylase activity
EE66_RS06645	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EE66_RS06650	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EE66_RS06655	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EE66_RS06665	COG0811	peptide transport
EE66_RS06670	COG0848	biopolymer transport protein
EE66_RS06690	COG0706	membrane insertase activity
EE66_RS06730	COG3118	belongs to the thioredoxin family
EE66_RS06735	COG1187	pseudouridine synthase activity
EE66_RS06740	COG0587	DNA-directed DNA polymerase activity
EE66_RS06765	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EE66_RS06770	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EE66_RS06780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EE66_RS06790	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EE66_RS06790	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EE66_RS06815	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EE66_RS06820	COG0163	prenyltransferase activity
EE66_RS06855	COG2226	methyltransferase
EE66_RS06860	COG1981	membrane
EE66_RS06865	COG1739	Uncharacterized protein family UPF0029
EE66_RS06880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EE66_RS06890	COG1253	flavin adenine dinucleotide binding
EE66_RS06895	COG0306	phosphate transporter
EE66_RS06900	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EE66_RS06910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EE66_RS06960	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EE66_RS06970	COG0786	glutamate:sodium symporter activity
EE66_RS06980	COG0348	domain, Protein
EE66_RS06985	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EE66_RS07005	COG1921	L-seryl-tRNASec selenium transferase activity
EE66_RS07010	COG0195	Participates in both transcription termination and antitermination
EE66_RS07045	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EE66_RS07060	COG0708	Exodeoxyribonuclease III
EE66_RS07090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EE66_RS07095	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
EE66_RS07130	COG0010	Belongs to the arginase family
EE66_RS07135	COG0833	amino acid
EE66_RS07140	COG0686	Belongs to the AlaDH PNT family
EE66_RS07160	COG0497	DNA recombination
EE66_RS07195	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EE66_RS07230	COG1074	ATP-dependent DNA helicase activity
EE66_RS07240	COG1862	Preprotein translocase
EE66_RS07245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EE66_RS07250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EE66_RS07260	COG0495	leucyl-tRNA aminoacylation
EE66_RS07270	COG0285	dihydrofolate synthase activity
EE66_RS07280	COG0739	heme binding
EE66_RS07290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EE66_RS07295	COG0723	plastoquinol--plastocyanin reductase activity
EE66_RS07320	COG0768	penicillin binding
EE66_RS07330	COG1558	bacterial-type flagellum-dependent cell motility
EE66_RS07335	COG1815	bacterial-type flagellum-dependent cell motility
EE66_RS07340	COG0772	Belongs to the SEDS family
EE66_RS07350	COG0450	alkyl hydroperoxide reductase
EE66_RS07360	COG0768	penicillin binding
EE66_RS07385	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EE66_RS07390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EE66_RS07395	COG0741	lytic transglycosylase activity
EE66_RS07395	COG1388	LysM domain
EE66_RS07400	COG0084	hydrolase, TatD family'
EE66_RS07405	COG0307	riboflavin synthase, alpha
EE66_RS07420	COG2011	ABC-type metal ion transport system permease component
EE66_RS07430	COG0671	phosphoesterase, PA-phosphatase related
EE66_RS07435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EE66_RS07465	COG4786	Flagellar basal body rod
EE66_RS07475	COG4735	regulation of single-species biofilm formation
EE66_RS07495	COG0288	reversible hydration of carbon dioxide
EE66_RS07540	COG0459	protein refolding
EE66_RS07550	COG0358	DNA primase activity
EE66_RS07555	COG0482	sulfurtransferase activity
EE66_RS07590	COG0835	chemotaxis
EE66_RS07590	COG0784	Response regulator, receiver
EE66_RS07600	COG0671	phosphoesterase, PA-phosphatase related
EE66_RS07605	COG2194	sulfuric ester hydrolase activity
EE66_RS07620	COG0287	Prephenate dehydrogenase
EE66_RS07625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EE66_RS07630	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EE66_RS07635	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
EE66_RS07640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EE66_RS07650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EE66_RS07655	COG1077	Cell shape determining protein MreB Mrl
EE66_RS07660	COG1792	Involved in formation and maintenance of cell shape
EE66_RS07675	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EE66_RS07690	COG0745	RESPONSE REGULATOR receiver
EE66_RS07695	COG0642	Histidine kinase
EE66_RS07700	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EE66_RS07700	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EE66_RS07705	COG0305	Participates in initiation and elongation during chromosome replication
EE66_RS07715	COG0109	protoheme IX farnesyltransferase activity
EE66_RS07735	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EE66_RS07740	COG0157	Belongs to the NadC ModD family
EE66_RS07750	COG0793	Belongs to the peptidase S41A family
EE66_RS07760	COG0204	Acyl-transferase
EE66_RS07770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EE66_RS07775	COG0126	phosphoglycerate kinase activity
EE66_RS07780	COG0598	Magnesium transport protein CorA
EE66_RS07785	COG0861	Integral membrane protein TerC family