locus-tag	class	description
HK442_RS00020	COG0708	Exodeoxyribonuclease III
HK442_RS00035	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HK442_RS00070	COG0195	Participates in both transcription termination and antitermination
HK442_RS00075	COG1921	L-seryl-tRNASec selenium transferase activity
HK442_RS00095	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HK442_RS00100	COG0348	domain, Protein
HK442_RS00110	COG0786	glutamate:sodium symporter activity
HK442_RS00170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HK442_RS00175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HK442_RS00185	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HK442_RS00190	COG0306	phosphate transporter
HK442_RS00195	COG1253	flavin adenine dinucleotide binding
HK442_RS00205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HK442_RS00220	COG1739	Uncharacterized protein family UPF0029
HK442_RS00230	COG2226	methyltransferase
HK442_RS00245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HK442_RS00265	COG0163	prenyltransferase activity
HK442_RS00270	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HK442_RS00295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HK442_RS00295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HK442_RS00305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HK442_RS00315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HK442_RS00320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HK442_RS00345	COG0587	DNA-directed DNA polymerase activity
HK442_RS00350	COG1187	pseudouridine synthase activity
HK442_RS00355	COG3118	belongs to the thioredoxin family
HK442_RS00380	COG0732	type I restriction modification DNA specificity domain
HK442_RS00455	COG4962	Type ii secretion system protein e
HK442_RS00475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HK442_RS00500	COG1192	Involved in chromosome partitioning
HK442_RS00550	COG4974	Belongs to the 'phage' integrase family
HK442_RS00565	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HK442_RS00575	COG4772	TonB-dependent receptor
HK442_RS00580	COG0010	Belongs to the arginase family
HK442_RS00585	COG0686	Belongs to the AlaDH PNT family
HK442_RS00605	COG0497	DNA recombination
HK442_RS00620	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HK442_RS00630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HK442_RS00665	COG0723	plastoquinol--plastocyanin reductase activity
HK442_RS00670	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HK442_RS00680	COG0739	heme binding
HK442_RS00690	COG0285	dihydrofolate synthase activity
HK442_RS00700	COG0495	leucyl-tRNA aminoacylation
HK442_RS00710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HK442_RS00715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HK442_RS00720	COG1862	Preprotein translocase
HK442_RS00725	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HK442_RS00745	COG0768	penicillin binding
HK442_RS00760	COG1558	bacterial-type flagellum-dependent cell motility
HK442_RS00770	COG0772	Belongs to the SEDS family
HK442_RS00785	COG0450	alkyl hydroperoxide reductase
HK442_RS00795	COG0768	penicillin binding
HK442_RS00820	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HK442_RS00825	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HK442_RS00830	COG0741	lytic transglycosylase activity
HK442_RS00830	COG1388	LysM domain
HK442_RS00835	COG0084	hydrolase, TatD family'
HK442_RS00840	COG0307	riboflavin synthase, alpha
HK442_RS00855	COG2011	ABC-type metal ion transport system permease component
HK442_RS00870	COG0671	phosphoesterase, PA-phosphatase related
HK442_RS00875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HK442_RS00895	COG4786	Flagellar basal body rod
HK442_RS00910	COG4735	regulation of single-species biofilm formation
HK442_RS00915	COG4735	regulation of single-species biofilm formation
HK442_RS00930	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HK442_RS00935	COG0288	reversible hydration of carbon dioxide
HK442_RS00940	COG0284	orotidine-5'-phosphate decarboxylase activity
HK442_RS00990	COG0358	DNA primase activity
HK442_RS00995	COG0482	sulfurtransferase activity
HK442_RS01030	COG0835	chemotaxis
HK442_RS01030	COG0784	Response regulator, receiver
HK442_RS01040	COG0671	phosphoesterase, PA-phosphatase related
HK442_RS01045	COG2194	sulfuric ester hydrolase activity
HK442_RS01065	COG0372	Belongs to the citrate synthase family
HK442_RS01070	COG0538	isocitrate dehydrogenase activity
HK442_RS01080	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HK442_RS01090	COG0589	response to stress
HK442_RS01095	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HK442_RS01100	COG0542	response to heat
HK442_RS01150	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HK442_RS01165	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HK442_RS01170	COG2957	Belongs to the agmatine deiminase family
HK442_RS01185	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HK442_RS01260	COG0830	nickel cation binding
HK442_RS01275	COG0804	urea catabolic process
HK442_RS01325	COG0840	transmembrane signaling receptor activity
HK442_RS01355	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HK442_RS01360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HK442_RS01365	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HK442_RS01400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HK442_RS01410	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HK442_RS01415	COG0840	transmembrane signaling receptor activity
HK442_RS01420	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HK442_RS01430	COG1216	Glycosyl transferase, family 2
HK442_RS01440	COG0737	Belongs to the 5'-nucleotidase family
HK442_RS01450	COG0626	cystathionine gamma-synthase activity
HK442_RS01455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HK442_RS01475	COG1420	regulation of RNA biosynthetic process
HK442_RS01495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HK442_RS01500	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HK442_RS01500	COG0551	DNA topoisomerase type I activity
HK442_RS01505	COG0731	radical SAM domain protein
HK442_RS01515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HK442_RS01515	COG0574	Belongs to the PEP-utilizing enzyme family
HK442_RS01525	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HK442_RS01555	COG1760	l-serine dehydratase
HK442_RS01560	COG0814	amino acid
HK442_RS01565	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HK442_RS01570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HK442_RS01580	COG1139	Iron-sulfur cluster binding protein
HK442_RS01585	COG0247	lactate metabolic process
HK442_RS01590	COG1620	l-lactate permease
HK442_RS01595	COG1620	l-lactate permease
HK442_RS01600	COG1194	a g-specific adenine glycosylase
HK442_RS01605	COG0471	metal ion transport
HK442_RS01610	COG3278	Belongs to the heme-copper respiratory oxidase family
HK442_RS01660	COG0148	phosphopyruvate hydratase activity
HK442_RS01690	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HK442_RS01700	COG0113	porphobilinogen synthase activity
HK442_RS01705	COG0642	Histidine kinase
HK442_RS01710	COG0745	RESPONSE REGULATOR receiver
HK442_RS01740	COG0303	'Molybdopterin
HK442_RS01755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HK442_RS01760	COG0191	fructose-bisphosphate aldolase activity
HK442_RS01775	COG0489	protein tyrosine kinase activity
HK442_RS01815	COG0105	UTP biosynthetic process
HK442_RS01825	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HK442_RS01830	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HK442_RS01845	COG1053	succinate dehydrogenase
HK442_RS01850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HK442_RS01855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HK442_RS01890	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HK442_RS01895	COG1136	(ABC) transporter
HK442_RS01900	COG2089	acid synthase
HK442_RS01915	COG0326	Molecular chaperone. Has ATPase activity
HK442_RS01920	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HK442_RS01935	COG0471	metal ion transport
HK442_RS01940	COG0575	Belongs to the CDS family
HK442_RS01950	COG1881	PFAM PEBP family protein
HK442_RS01960	COG1104	cysteine desulfurase activity
HK442_RS01975	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HK442_RS01980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HK442_RS01980	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HK442_RS01985	COG0730	response to heat
HK442_RS01995	COG0659	secondary active sulfate transmembrane transporter activity
HK442_RS02025	COG0754	glutathionylspermidine amidase activity
HK442_RS02075	COG0783	Belongs to the Dps family
HK442_RS02080	COG0642	Histidine kinase
HK442_RS02085	COG3951	Flagellar rod assembly protein muramidase FlgJ
HK442_RS02110	COG4172	Belongs to the ABC transporter superfamily
HK442_RS02150	COG0750	zinc metalloprotease
HK442_RS02200	COG0542	response to heat
HK442_RS02205	COG0785	Cytochrome C biogenesis protein
HK442_RS02210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HK442_RS02215	COG0402	S-adenosylhomocysteine deaminase activity
HK442_RS02250	COG0727	PFAM Uncharacterised protein family (UPF0153)
HK442_RS02260	COG0134	indole-3-glycerol-phosphate synthase activity
HK442_RS02270	COG0248	Ppx GppA phosphatase
HK442_RS02275	COG0859	PFAM glycosyl transferase family 9
HK442_RS02305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HK442_RS02310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HK442_RS02330	COG0019	diaminopimelate decarboxylase activity
HK442_RS02345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HK442_RS02385	COG0747	negative chemotaxis
HK442_RS02390	COG0601	transmembrane transport
HK442_RS02395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HK442_RS02400	COG0444	Belongs to the ABC transporter superfamily
HK442_RS02405	COG4608	Belongs to the ABC transporter superfamily
HK442_RS02440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HK442_RS02455	COG0523	cobalamin synthesis protein
HK442_RS02465	COG0748	coenzyme F420 binding
HK442_RS02475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HK442_RS02500	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HK442_RS02505	COG3980	spore coat polysaccharide biosynthesis protein
HK442_RS02510	COG3980	spore coat polysaccharide biosynthesis protein
HK442_RS02515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HK442_RS02520	COG1663	tetraacyldisaccharide 4'-kinase activity
HK442_RS02540	COG2894	cell division
HK442_RS02550	COG0758	DNA mediated transformation
HK442_RS02550	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HK442_RS02555	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HK442_RS02560	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HK442_RS02575	COG0564	pseudouridine synthase activity
HK442_RS02580	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HK442_RS02580	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HK442_RS02585	COG0504	CTP synthase activity
HK442_RS02595	COG1766	The M ring may be actively involved in energy transduction
HK442_RS02600	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HK442_RS02610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HK442_RS02635	COG3842	ATPase activity
HK442_RS02645	COG4786	Flagellar basal body rod
HK442_RS02650	COG0477	Major facilitator Superfamily
HK442_RS02655	COG0675	Transposase, IS605 OrfB family
HK442_RS02665	COG1674	ftsk spoiiie
HK442_RS02675	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HK442_RS02680	COG0196	riboflavin kinase activity
HK442_RS02685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HK442_RS02705	COG1132	(ABC) transporter
HK442_RS02720	COG1106	Psort location Cytoplasmic, score
HK442_RS02730	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HK442_RS02750	COG2608	mercury ion transmembrane transporter activity
HK442_RS02755	COG2217	Heavy metal translocating P-type atpase
HK442_RS02760	COG1183	phosphatidylcholine synthase activity
HK442_RS02770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HK442_RS02775	COG2264	protein methyltransferase activity
HK442_RS02780	COG0745	RESPONSE REGULATOR receiver
HK442_RS02805	COG0357	Ribosomal RNA small subunit methyltransferase G
HK442_RS02815	COG0805	protein transport
HK442_RS02860	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HK442_RS02870	COG0083	homoserine kinase activity
HK442_RS02885	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HK442_RS02900	COG1408	metallophosphoesterase
HK442_RS02905	COG0745	RESPONSE REGULATOR receiver
HK442_RS02910	COG2404	hydrolase activity, acting on ester bonds
HK442_RS02915	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HK442_RS02920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HK442_RS02935	COG0006	proline dipeptidase activity
HK442_RS02940	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HK442_RS02945	COG1419	protein localization to endoplasmic reticulum
HK442_RS02950	COG0455	bacterial-type flagellum organization
HK442_RS02965	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HK442_RS02970	COG1776	CheC inhibitor of MCP methylation
HK442_RS02970	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HK442_RS02985	COG0735	belongs to the Fur family
HK442_RS02990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HK442_RS02990	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HK442_RS02995	COG0789	Transcriptional regulator
HK442_RS03000	COG0484	heat shock protein binding
HK442_RS03015	COG0745	RESPONSE REGULATOR receiver
HK442_RS03020	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HK442_RS03020	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HK442_RS03030	COG0833	amino acid
HK442_RS03035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HK442_RS03045	COG1028	Short-chain dehydrogenase reductase Sdr
HK442_RS03050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HK442_RS03065	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HK442_RS03235	COG2824	Alkylphosphonate utilization operon protein PhnA
HK442_RS03245	COG1749	Flagellar hook protein flgE
HK442_RS03250	COG0375	protein maturation
HK442_RS03265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HK442_RS03270	COG0756	dUTP diphosphatase activity
HK442_RS03285	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HK442_RS03295	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HK442_RS03300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HK442_RS03305	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HK442_RS03305	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HK442_RS03310	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HK442_RS03320	COG1696	Membrane protein involved in D-alanine export
HK442_RS03330	COG0488	(ABC) transporter
HK442_RS03340	COG0671	phosphoesterase, PA-phosphatase related
HK442_RS03385	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HK442_RS03390	COG0351	phosphomethylpyrimidine kinase
HK442_RS03405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HK442_RS03410	COG1086	Polysaccharide biosynthesis protein
HK442_RS03435	COG0776	regulation of translation
HK442_RS03455	COG0237	dephospho-CoA kinase activity
HK442_RS03465	COG0517	IMP dehydrogenase activity
HK442_RS03465	COG0516	GMP reductase activity
HK442_RS03475	COG0724	RNA recognition motif
HK442_RS03485	COG0492	ferredoxin-NADP+ reductase activity
HK442_RS03490	COG3118	belongs to the thioredoxin family
HK442_RS03500	COG0460	homoserine dehydrogenase
HK442_RS03520	COG1125	glycine betaine transport
HK442_RS03520	COG0517	IMP dehydrogenase activity
HK442_RS03525	COG1732	Glycine betaine
HK442_RS03535	COG1360	Flagellar Motor Protein
HK442_RS03540	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HK442_RS03545	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HK442_RS03550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HK442_RS03570	COG1580	Controls the rotational direction of flagella during chemotaxis
HK442_RS03575	COG0736	holo-[acyl-carrier-protein] synthase activity
HK442_RS03595	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HK442_RS03595	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HK442_RS03615	COG0314	molybdopterin synthase activity
HK442_RS03620	COG0521	Mo-molybdopterin cofactor biosynthetic process
HK442_RS03655	COG0606	chelatase, subunit chli
HK442_RS03660	COG2217	Heavy metal translocating P-type atpase
HK442_RS03665	COG0732	type I restriction modification DNA specificity domain
HK442_RS03685	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HK442_RS03715	COG1049	propionate catabolic process, 2-methylcitrate cycle
HK442_RS03725	COG0528	UMP kinase activity
HK442_RS03730	COG1758	RNA polymerase activity
HK442_RS03735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HK442_RS03740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HK442_RS03750	COG0860	N-Acetylmuramoyl-L-alanine amidase
HK442_RS03760	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HK442_RS03765	COG0746	molybdenum cofactor guanylyltransferase activity
HK442_RS03770	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HK442_RS03795	COG0552	protein localization to endoplasmic reticulum
HK442_RS03815	COG0534	Mate efflux family protein
HK442_RS03820	COG2056	Na+-H+ antiporter family
HK442_RS03850	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HK442_RS03870	COG2884	Cell division ATP-binding protein ftsE
HK442_RS03875	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HK442_RS03885	COG0564	pseudouridine synthase activity
HK442_RS03890	COG1162	GTPase activity
HK442_RS03900	COG0772	Belongs to the SEDS family
HK442_RS03910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HK442_RS03920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HK442_RS03935	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HK442_RS03940	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HK442_RS03945	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HK442_RS03985	COG0037	tRNA processing
HK442_RS03990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HK442_RS04005	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HK442_RS04010	COG0252	asparaginase activity
HK442_RS04030	COG1279	arginine transmembrane transporter activity
HK442_RS04035	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HK442_RS04045	COG1137	ATPase activity
HK442_RS04050	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HK442_RS04075	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HK442_RS04095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HK442_RS04105	COG2204	response regulator
HK442_RS04115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HK442_RS04120	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HK442_RS04135	COG4647	ligase activity
HK442_RS04140	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HK442_RS04145	COG0145	ligase activity
HK442_RS04155	COG2031	fatty acid transporter
HK442_RS04160	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HK442_RS04165	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HK442_RS04170	COG0183	Belongs to the thiolase family
HK442_RS04180	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HK442_RS04190	COG1338	Plays a role in the flagellum-specific transport system
HK442_RS04195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HK442_RS04210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HK442_RS04220	COG0730	response to heat
HK442_RS04230	COG4974	Belongs to the 'phage' integrase family
HK442_RS04265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HK442_RS04275	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HK442_RS04285	COG0328	RNA-DNA hybrid ribonuclease activity
HK442_RS04300	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HK442_RS04310	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HK442_RS04315	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HK442_RS04320	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HK442_RS04325	COG1528	Iron-storage protein
HK442_RS04330	COG0560	Phosphoserine phosphatase
HK442_RS04345	COG1027	Aspartate ammonia-lyase
HK442_RS04375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HK442_RS04415	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HK442_RS04420	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HK442_RS04425	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HK442_RS04430	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HK442_RS04435	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HK442_RS04440	COG2249	NAD(P)H dehydrogenase (quinone) activity
HK442_RS04455	COG2171	N-acyltransferase activity
HK442_RS04465	COG0436	Aminotransferase
HK442_RS04480	COG1193	negative regulation of DNA recombination
HK442_RS04485	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HK442_RS04500	COG0563	adenylate kinase activity
HK442_RS04510	COG0835	chemotaxis
HK442_RS04510	COG0784	Response regulator, receiver
HK442_RS04525	COG1131	(ABC) transporter
HK442_RS04535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HK442_RS04575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HK442_RS04585	COG0840	transmembrane signaling receptor activity
HK442_RS04590	COG0156	8-amino-7-oxononanoate synthase activity
HK442_RS04595	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HK442_RS04635	COG1013	pyruvate-flavodoxin oxidoreductase activity
HK442_RS04640	COG0674	pyruvate-flavodoxin oxidoreductase activity
HK442_RS04640	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HK442_RS04660	COG1918	ferrous iron import across plasma membrane
HK442_RS04665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HK442_RS04670	COG1776	CheC inhibitor of MCP methylation
HK442_RS04670	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HK442_RS04705	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HK442_RS04710	COG0681	Belongs to the peptidase S26 family
HK442_RS04715	COG1994	Peptidase M50
HK442_RS04720	COG0698	ribose 5-phosphate isomerase
HK442_RS04740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HK442_RS04745	COG0012	GTP binding
HK442_RS04755	COG0628	permease
HK442_RS04785	COG1028	Short-chain dehydrogenase reductase Sdr
HK442_RS04795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HK442_RS04820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HK442_RS04825	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HK442_RS04835	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HK442_RS04850	COG0174	glutamine synthetase
HK442_RS04925	COG0277	FAD linked oxidase domain protein
HK442_RS04940	COG0739	heme binding
HK442_RS04940	COG0741	lytic transglycosylase activity
HK442_RS04940	COG1196	nuclear chromosome segregation
HK442_RS04950	COG0187	DNA topoisomerase II activity
HK442_RS04955	COG0592	DNA-directed DNA polymerase activity
HK442_RS04965	COG0733	neurotransmitter:sodium symporter activity
HK442_RS04970	COG0733	neurotransmitter:sodium symporter activity
HK442_RS04975	COG0824	Thioesterase
HK442_RS04985	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HK442_RS05035	COG0632	four-way junction helicase activity
HK442_RS05045	COG0728	peptidoglycan biosynthetic process
HK442_RS05050	COG0215	cysteine-tRNA ligase activity
HK442_RS05060	COG1120	ATPase activity
HK442_RS05065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HK442_RS05070	COG0300	oxidoreductase activity
HK442_RS05075	COG1607	acyl-coa hydrolase
HK442_RS05110	COG0409	Hydrogenase expression formation protein
HK442_RS05115	COG0298	carbon dioxide binding
HK442_RS05120	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HK442_RS05135	COG0280	phosphate acetyltransferase
HK442_RS05140	COG0280	phosphate acetyltransferase
HK442_RS05150	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HK442_RS05155	COG1749	Flagellar hook protein flgE
HK442_RS05155	COG1749	Flagellar hook protein flgE
HK442_RS05205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HK442_RS05210	COG0670	Belongs to the BI1 family
HK442_RS05215	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HK442_RS05230	COG1942	4-Oxalocrotonate Tautomerase
HK442_RS05240	COG0585	pseudouridine synthase activity
HK442_RS05255	COG0142	geranyltranstransferase activity
HK442_RS05260	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HK442_RS05270	COG0720	synthase
HK442_RS05275	COG0602	queuosine metabolic process
HK442_RS05305	COG0765	amino acid transport
HK442_RS05310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HK442_RS05320	COG1115	amino acid carrier protein
HK442_RS05325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HK442_RS05330	COG0251	oxidation-reduction process
HK442_RS05355	COG1757	Na H antiporter
HK442_RS05375	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HK442_RS05385	COG1058	Belongs to the CinA family
HK442_RS05385	COG1546	Belongs to the CinA family
HK442_RS05400	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HK442_RS05405	COG0564	pseudouridine synthase activity
HK442_RS05410	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HK442_RS05410	COG1519	Transferase
HK442_RS05420	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HK442_RS05440	COG1160	GTP binding
HK442_RS05480	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HK442_RS05490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HK442_RS05500	COG0849	cell division
HK442_RS05505	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HK442_RS05520	COG0668	transmembrane transport
HK442_RS05620	COG3451	type IV secretory pathway VirB4
HK442_RS05625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HK442_RS05665	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HK442_RS05690	COG3041	Addiction module toxin RelE StbE family
HK442_RS05715	COG1192	Involved in chromosome partitioning
HK442_RS05750	COG0582	viral genome integration into host DNA
HK442_RS05765	COG1598	PFAM Uncharacterised protein family UPF0150
HK442_RS05775	COG1166	arginine decarboxylase activity
HK442_RS05790	COG0500	methyltransferase
HK442_RS05800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HK442_RS05800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HK442_RS05805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HK442_RS05810	COG0668	transmembrane transport
HK442_RS05840	COG0519	Catalyzes the synthesis of GMP from XMP
HK442_RS05840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HK442_RS05860	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HK442_RS05865	COG0537	adenosine 5'-monophosphoramidase activity
HK442_RS05875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HK442_RS05875	COG0072	phenylalanine-tRNA ligase activity
HK442_RS05880	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HK442_RS05890	COG0539	negative regulation of cytoplasmic translation
HK442_RS05890	COG1185	polyribonucleotide nucleotidyltransferase activity
HK442_RS05900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HK442_RS05905	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HK442_RS05910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HK442_RS05920	COG0835	chemotaxis
HK442_RS05920	COG0784	Response regulator, receiver
HK442_RS05925	COG0643	Histidine kinase
HK442_RS05925	COG2198	Histidine kinase
HK442_RS05925	COG0784	Response regulator, receiver
HK442_RS05930	COG0835	chemotaxis
HK442_RS05935	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HK442_RS05940	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HK442_RS05950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HK442_RS05975	COG0501	Belongs to the peptidase M48B family
HK442_RS05980	COG2890	protein-(glutamine-N5) methyltransferase activity
HK442_RS05985	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HK442_RS05995	COG1333	cytochrome c biogenesis protein
HK442_RS05995	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HK442_RS06015	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HK442_RS06030	COG0511	ligase activity, forming carbon-carbon bonds
HK442_RS06035	COG0439	Biotin carboxylase
HK442_RS06065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HK442_RS06075	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HK442_RS06135	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HK442_RS06140	COG0800	Aldolase
HK442_RS06145	COG0129	dihydroxy-acid dehydratase activity
HK442_RS06150	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HK442_RS06155	COG0363	glucosamine-6-phosphate deaminase activity
HK442_RS06165	COG1064	alcohol dehydrogenase
HK442_RS06185	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HK442_RS06195	COG0674	pyruvate-flavodoxin oxidoreductase activity
HK442_RS06200	COG1013	pyruvate-flavodoxin oxidoreductase activity
HK442_RS06205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HK442_RS06215	COG0556	nucleotide-excision repair
HK442_RS06240	COG0405	Gamma-glutamyltransferase
HK442_RS06270	COG1047	Peptidyl-prolyl cis-trans
HK442_RS06280	COG2885	chlorophyll binding
HK442_RS06285	COG0823	Involved in the tonB-independent uptake of proteins
HK442_RS06295	COG0848	biopolymer transport protein
HK442_RS06300	COG0811	peptide transport
HK442_RS06310	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HK442_RS06340	COG1475	DNA binding
HK442_RS06345	COG1192	Involved in chromosome partitioning
HK442_RS06355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HK442_RS06395	COG0336	Belongs to the RNA methyltransferase TrmD family
HK442_RS06400	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HK442_RS06415	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HK442_RS06420	COG0525	valine-tRNA ligase activity
HK442_RS06430	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HK442_RS06445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HK442_RS06450	COG2184	nucleotidyltransferase activity
HK442_RS06460	COG0716	FMN binding
HK442_RS06475	COG0492	ferredoxin-NADP+ reductase activity
HK442_RS06485	COG0166	Belongs to the GPI family
HK442_RS06495	COG1966	Carbon starvation protein
HK442_RS06505	COG0765	amino acid transport
HK442_RS06510	COG1126	abc transporter atp-binding protein
HK442_RS06525	COG0738	Major facilitator superfamily
HK442_RS06530	COG2252	PERMEase
HK442_RS06570	COG2814	Major facilitator Superfamily
HK442_RS06575	COG0037	tRNA processing
HK442_RS06580	COG0569	domain protein
HK442_RS06580	COG0475	glutathione-regulated potassium exporter activity
HK442_RS06605	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HK442_RS06610	COG0124	histidyl-tRNA synthetase
HK442_RS06625	COG0667	Aldo Keto reductase
HK442_RS06645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HK442_RS06645	COG0085	RNA polymerase activity
HK442_RS06670	COG0250	Participates in transcription elongation, termination and antitermination
HK442_RS06690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HK442_RS06715	COG1132	(ABC) transporter
HK442_RS06735	COG1045	serine acetyltransferase
HK442_RS06780	COG0151	Belongs to the GarS family
HK442_RS06795	COG1131	(ABC) transporter
HK442_RS06800	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HK442_RS06825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HK442_RS06830	COG2863	cytochrome
HK442_RS06840	COG0527	aspartate kinase activity
HK442_RS06855	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HK442_RS06865	COG0697	spore germination
HK442_RS06880	COG0505	Belongs to the CarA family
HK442_RS06895	COG0424	maF-like protein
HK442_RS06920	COG0629	single-stranded DNA binding
HK442_RS06930	COG1466	dna polymerase III delta subunit
HK442_RS06935	COG0557	exoribonuclease II activity
HK442_RS06940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HK442_RS06950	COG4174	ABC transporter (Permease)
HK442_RS06955	COG4166	transmembrane transport
HK442_RS06960	COG0180	Tryptophanyl-tRNA synthetase
HK442_RS06970	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HK442_RS06990	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HK442_RS06995	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HK442_RS07005	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HK442_RS07040	COG0839	Belongs to the complex I subunit 6 family
HK442_RS07050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HK442_RS07060	COG1007	ATP synthesis coupled electron transport
HK442_RS07100	COG0133	tryptophan synthase activity
HK442_RS07105	COG0135	phosphoribosylanthranilate isomerase activity
HK442_RS07105	COG0134	indole-3-glycerol-phosphate synthase activity
HK442_RS07110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HK442_RS07115	COG0512	Glutamine amidotransferase of anthranilate synthase
HK442_RS07120	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HK442_RS07135	COG0859	PFAM glycosyl transferase family 9
HK442_RS07145	COG2353	YceI-like domain
HK442_RS07150	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HK442_RS07185	COG0202	RNA polymerase activity
HK442_RS07210	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HK442_RS07215	COG0024	Methionine aminopeptidase
HK442_RS07220	COG0201	protein transport
HK442_RS07255	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HK442_RS07275	COG0255	Belongs to the universal ribosomal protein uL29 family
HK442_RS07315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HK442_RS07345	COG0114	fumarate hydratase activity
HK442_RS07360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HK442_RS07365	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HK442_RS07370	COG1687	branched-chain amino acid
HK442_RS07375	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HK442_RS07380	COG0484	heat shock protein binding
HK442_RS07415	COG0811	peptide transport
HK442_RS07420	COG0848	biopolymer transport protein
HK442_RS07425	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HK442_RS07435	COG0861	Integral membrane protein TerC family
HK442_RS07440	COG0598	Magnesium transport protein CorA
HK442_RS07445	COG0126	phosphoglycerate kinase activity
HK442_RS07450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HK442_RS07460	COG0204	Acyl-transferase
HK442_RS07470	COG0793	Belongs to the peptidase S41A family
HK442_RS07500	COG0157	Belongs to the NadC ModD family
HK442_RS07505	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HK442_RS07525	COG0109	protoheme IX farnesyltransferase activity
HK442_RS07535	COG0305	Participates in initiation and elongation during chromosome replication
HK442_RS07540	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HK442_RS07540	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HK442_RS07545	COG0642	Histidine kinase
HK442_RS07550	COG0745	RESPONSE REGULATOR receiver
HK442_RS07555	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HK442_RS07570	COG1077	Cell shape determining protein MreB Mrl
HK442_RS07575	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HK442_RS07595	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HK442_RS07600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HK442_RS07605	COG0287	Prephenate dehydrogenase
HK442_RS07615	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HK442_RS07620	COG3421	Type III restriction
HK442_RS07635	COG1295	ribonuclease BN
HK442_RS07675	COG0799	negative regulation of ribosome biogenesis
HK442_RS07680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HK442_RS07700	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HK442_RS07705	COG1987	bacterial-type flagellum assembly
HK442_RS07710	COG1157	protein secretion by the type III secretion system
HK442_RS07715	COG4962	Type ii secretion system protein e
HK442_RS07725	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HK442_RS07750	COG0517	IMP dehydrogenase activity
HK442_RS07750	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HK442_RS07760	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HK442_RS07770	COG0732	type I restriction modification DNA specificity domain
HK442_RS07775	COG0788	formyltetrahydrofolate deformylase activity
HK442_RS07820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HK442_RS07825	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HK442_RS07830	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HK442_RS07840	COG0811	peptide transport
HK442_RS07845	COG0848	biopolymer transport protein
HK442_RS07860	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HK442_RS07865	COG0706	membrane insertase activity
HK442_RS07875	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HK442_RS07905	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HK442_RS07910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HK442_RS07930	COG3177	Filamentation induced by cAMP protein fic