locus-tag	class	description
HK440_RS00020	ENOG4105CGK	Exodeoxyribonuclease III
HK440_RS00035	ENOG4105CB5	ATP-dependent DNA helicase recG
HK440_RS00040	ENOG4107QMH	DNA methylase
HK440_RS00070	ENOG4105CHV	Transcription elongation factor NusA
HK440_RS00075	ENOG4105C1Y	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity)
HK440_RS00095	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HK440_RS00100	ENOG4105C58	cytochrome c oxidase accessory protein ccog
HK440_RS00110	ENOG4105D6U	Sodium Glutamate Symporter
HK440_RS00120	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
HK440_RS00170	ENOG4107V25	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HK440_RS00175	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HK440_RS00185	ENOG41083MR	nifu domain-containing protein
HK440_RS00190	ENOG4105CJ3	phosphate transporter
HK440_RS00195	ENOG4105C37	(CBS) domain
HK440_RS00205	ENOG4107V40	secretion protein, HlyD family
HK440_RS00220	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HK440_RS00225	ENOG4108YXA	Membrane
HK440_RS00230	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HK440_RS00245	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HK440_RS00265	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
HK440_RS00270	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HK440_RS00295	ENOG4105C2M	dna polymerase I
HK440_RS00305	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HK440_RS00320	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HK440_RS00340	ENOG4105CA0	peroxidase
HK440_RS00345	ENOG4105C0B	DNA polymerase III (alpha subunit)
HK440_RS00350	ENOG4105FE9	pseudouridine synthase
HK440_RS00355	ENOG4105K63	Thioredoxin
HK440_RS00380	ENOG41060B8	Type I Restriction
HK440_RS00480	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HK440_RS00505	ENOG4107QJE	Chromosome Partitioning Protein
HK440_RS00560	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HK440_RS00575	ENOG4105DZR	Type I site-specific deoxyribonuclease
HK440_RS00585	ENOG4105GAV	receptor
HK440_RS00590	ENOG41088SP	formiminoglutamate hydrolase
HK440_RS00595	ENOG4105DCF	alanine dehydrogenase
HK440_RS00615	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HK440_RS00630	ENOG4105EUU	Sel1 domain protein repeat-containing protein
HK440_RS00640	ENOG4105DJV	ribulose-phosphate 3-epimerase
HK440_RS00670	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HK440_RS00675	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HK440_RS00680	ENOG4108JA2	transcriptioN-repair coupling factor
HK440_RS00690	ENOG4105DR5	peptidase
HK440_RS00700	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HK440_RS00710	ENOG4105C8T	Leucyl-tRNA synthetase
HK440_RS00720	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HK440_RS00725	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HK440_RS00730	ENOG4105VIE	preprotein translocase, subunit YajC
HK440_RS00735	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HK440_RS00740	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
HK440_RS00755	ENOG4105CJN	penicillin-binding protein
HK440_RS00770	ENOG4108ZC9	flagellar basal-body rod protein flgc
HK440_RS00780	ENOG4105CNI	cell division protein FtsW
HK440_RS00795	ENOG4105D3R	alkyl hydroperoxide reductase
HK440_RS00800	ENOG4105D01	(LipO)protein
HK440_RS00805	ENOG4105CJN	penicillin-binding protein
HK440_RS00835	ENOG4105K6T	rare lipoprotein A
HK440_RS00840	ENOG4105E9H	Lytic Murein transglycosylase
HK440_RS00845	ENOG4105F8V	Hydrolase, tatD family
HK440_RS00850	ENOG4108R6K	riboflavin synthase, subunit alpha
HK440_RS00865	ENOG4108UMI	ABC transporter, permease
HK440_RS00880	ENOG4105P1V	phosphoesterase PA-phosphatase related protein
HK440_RS00885	ENOG4105ESV	Glycosyl transferase, family 4
HK440_RS00905	ENOG4105CGA	flagellar basal-body rod protein FlgG
HK440_RS00920	ENOG4108QDQ	Ubiquinol-cytochrome C chaperone 
HK440_RS00925	ENOG4108QDQ	Ubiquinol-cytochrome C chaperone 
HK440_RS00940	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HK440_RS00950	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
HK440_RS01000	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HK440_RS01005	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HK440_RS01055	ENOG4105DIJ	Phosphoethanolamine transferase
HK440_RS01070	ENOG4105D7V	transposase
HK440_RS01075	ENOG4105BZN	citrate synthase
HK440_RS01080	ENOG4108HMX	isocitrate dehydrogenase (NADP)
HK440_RS01085	ENOG4105RX8	Protein of unknown function (DUF1523)
HK440_RS01090	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HK440_RS01105	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
HK440_RS01110	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HK440_RS01155	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
HK440_RS01160	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
HK440_RS01175	ENOG4105C45	hydrogenase expression formation protein (HypE)
HK440_RS01185	ENOG4105DWY	Agmatine deiminase
HK440_RS01200	ENOG4105CK7	Sodium proline symporter
HK440_RS01275	ENOG4108YH3	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
HK440_RS01285	ENOG4105IW1	AmiS UreI transporter
HK440_RS01290	ENOG4105CQM	Urea amidohydrolase subunit alpha
HK440_RS01340	ENOG4105C8Q	Methyl-accepting chemotaxis
HK440_RS01370	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HK440_RS01375	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HK440_RS01380	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HK440_RS01410	ENOG4105C5I	Dehydrogenase
HK440_RS01420	ENOG4107QID	Threonine synthase
HK440_RS01425	ENOG4105C8Q	Methyl-accepting chemotaxis
HK440_RS01430	ENOG4105WPN	DNA integration recombination invertion protein
HK440_RS01440	ENOG4105K64	Glycosyl transferase, family 2
HK440_RS01445	ENOG4105C8Q	Methyl-accepting chemotaxis
HK440_RS01450	ENOG4105CGH	5'-nucleotidase
HK440_RS01460	ENOG4105C28	cystathionine
HK440_RS01465	ENOG4105C6T	cysteine synthase
HK440_RS01505	ENOG4105I03	Flagellin
HK440_RS01510	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HK440_RS01515	ENOG41082XB	radical SAM domain protein
HK440_RS01525	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HK440_RS01535	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HK440_RS01565	ENOG4105EJQ	L-serine dehydratase
HK440_RS01570	ENOG4105C44	Serine transporter
HK440_RS01575	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
HK440_RS01580	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HK440_RS01585	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
HK440_RS01590	ENOG4107QR9	Iron-sulfur cluster binding protein
HK440_RS01595	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HK440_RS01600	ENOG4105DAA	L-lactate
HK440_RS01605	ENOG4105DAA	L-lactate
HK440_RS01610	ENOG4105CEN	a g-specific adenine glycosylase
HK440_RS01615	ENOG4107QPK	)-transporter
HK440_RS01620	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
HK440_RS01670	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HK440_RS01700	ENOG4105EUU	Sel1 domain protein repeat-containing protein
HK440_RS01710	ENOG4105D52	delta-aminolevulinic acid dehydratase
HK440_RS01735	ENOG4105CFP	Peptidase U32
HK440_RS01750	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HK440_RS01765	ENOG4105EIN	peptidylprolyl cis-trans isomerase
HK440_RS01770	ENOG4105D2N	Aldolase
HK440_RS01785	ENOG4105D1F	ATP-binding protein
HK440_RS01825	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HK440_RS01835	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HK440_RS01840	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
HK440_RS01850	ENOG4108S24	Fumarate reduCtase
HK440_RS01855	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
HK440_RS01860	ENOG4105E33	succinate dehydrogenase
HK440_RS01865	ENOG4107RZC	phospholipase d
HK440_RS01900	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HK440_RS01905	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HK440_RS01910	ENOG4105D2T	synthase
HK440_RS01925	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HK440_RS01930	ENOG4108730	Sel1 domain protein repeat-containing protein
HK440_RS01945	ENOG4105C8P	)-transporter
HK440_RS01950	ENOG4105KNE	Phosphatidate cytidylyltransferase
HK440_RS01960	ENOG4105KIS	phospholipid-binding protein
HK440_RS01970	ENOG4105C3J	Cysteine desulfurase
HK440_RS01985	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HK440_RS01990	ENOG4108F19	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HK440_RS01995	ENOG4108VCT	Sulfite exporter TauE/SafE
HK440_RS02005	ENOG4105CHH	sulfate transporter
HK440_RS02030	ENOG4108UHV	Lipoprotein
HK440_RS02035	ENOG4106032	Glutathionylspermidine synthase
HK440_RS02085	ENOG4108RMU	ferritin dps family protein
HK440_RS02095	ENOG4105YKR	
HK440_RS02120	ENOG4108JQ5	ABC transporter
HK440_RS02160	ENOG4105DZP	Membrane-associated zinc metalloprotease
HK440_RS02170	ENOG4107QMH	DNA methylase
HK440_RS02185	ENOG4105UHH	
HK440_RS02195	ENOG4105D7V	transposase
HK440_RS02210	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HK440_RS02215	ENOG4107QIV	Cytochrome c biogenesis protein
HK440_RS02220	ENOG4105CD3	dihydroorotase
HK440_RS02225	ENOG4107SYB	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HK440_RS02260	ENOG4105QTX	Pfam:UPF0153
HK440_RS02270	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HK440_RS02280	ENOG4107R33	ppx gppa phosphatase
HK440_RS02285	ENOG4105DKP	glycosyl transferase, family 9
HK440_RS02315	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HK440_RS02320	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HK440_RS02340	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HK440_RS02355	ENOG4105CRQ	synthase (Component I)
HK440_RS02370	ENOG4105D7V	transposase
HK440_RS02395	ENOG4105DEF	Extracellular solute-binding protein, family 5
HK440_RS02400	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HK440_RS02405	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HK440_RS02410	ENOG4105C3U	ABC transporter
HK440_RS02415	ENOG4108JQ7	(ABC) transporter
HK440_RS02450	ENOG4105CQP	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
HK440_RS02465	ENOG4105CKI	cobalamin synthesis protein
HK440_RS02475	ENOG4108WHG	pyridoxamine 5'-phosphate
HK440_RS02485	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HK440_RS02510	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HK440_RS02515	ENOG4105F0R	Cytidylyltransferase
HK440_RS02520	ENOG4105F0R	Cytidylyltransferase
HK440_RS02525	ENOG4105VDT	-acetyltransferase
HK440_RS02530	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HK440_RS02550	ENOG4107QMS	site-determining protein
HK440_RS02565	ENOG4105GSH	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HK440_RS02570	ENOG4105EUU	Sel1 domain protein repeat-containing protein
HK440_RS02585	ENOG4105EI2	Pseudouridine synthase
HK440_RS02590	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HK440_RS02595	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HK440_RS02605	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HK440_RS02610	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HK440_RS02620	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HK440_RS02645	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HK440_RS02655	ENOG4105CGA	flagellar basal-body rod protein FlgG
HK440_RS02660	ENOG4105CSH	Transporter
HK440_RS02665	ENOG4105D7V	transposase
HK440_RS02675	ENOG4105CNU	cell division protein FtsK
HK440_RS02685	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HK440_RS02690	ENOG4105U1N	riboflavin
HK440_RS02695	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HK440_RS02715	ENOG4105BZ1	(ABC) transporter
HK440_RS02730	ENOG41090JH	(ATPase)-like protein
HK440_RS02740	ENOG4105D9G	High-affinity
HK440_RS02765	ENOG4105C59	p-type ATPase
HK440_RS02770	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
HK440_RS02780	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HK440_RS02785	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HK440_RS02815	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HK440_RS02825	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HK440_RS02870	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HK440_RS02880	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HK440_RS02910	ENOG4105DIN	metallophosphoesterase
HK440_RS02920	ENOG4108KA0	Inherit from COG: Phosphoesterase, DHHA1
HK440_RS02925	ENOG4105D7B	Flagellar biosynthesis protein flha
HK440_RS02930	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HK440_RS02945	ENOG4105DC7	peptidase M24
HK440_RS02950	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HK440_RS02955	ENOG4105FZW	flagellar biosynthesis regulator FlhF
HK440_RS02960	ENOG4107R21	site-determining protein
HK440_RS02970	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HK440_RS02975	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HK440_RS02980	ENOG4105DD5	Flagellar motor switch protein
HK440_RS02995	ENOG41090R7	Ferric uptake
HK440_RS03000	ENOG4105D1H	recombination factor protein RarA
HK440_RS03005	ENOG4105KNI	merR family transcriptional Regulator
HK440_RS03010	ENOG4105DVC	DnaJ domain protein
HK440_RS03020	ENOG4105C2M	dna polymerase I
HK440_RS03025	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HK440_RS03030	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HK440_RS03035	ENOG4105C0H	protease
HK440_RS03040	ENOG4108IQI	permease
HK440_RS03045	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
HK440_RS03055	ENOG4105CAN	Short-chain dehydrogenase reductase Sdr
HK440_RS03060	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HK440_RS03075	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HK440_RS03130	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HK440_RS03140	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
HK440_RS03145	ENOG4105E0C	molybdate abc transporter
HK440_RS03175	ENOG4105CI3	gtp-binding protein typa
HK440_RS03225	ENOG4107RNH	Outer membrane receptor FepA
HK440_RS03245	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HK440_RS03255	ENOG4105BZE	flagellar hook protein, FlgE
HK440_RS03260	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
HK440_RS03275	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HK440_RS03280	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HK440_RS03290	ENOG4108TX7	
HK440_RS03295	ENOG4108VHG	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
HK440_RS03305	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
HK440_RS03310	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
HK440_RS03315	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HK440_RS03320	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HK440_RS03330	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HK440_RS03340	ENOG4105C5H	ABC transporter
HK440_RS03350	ENOG410841Q	phosphoesterase PA-phosphatase related protein
HK440_RS03360	ENOG4105DVF	Cytosine-specific methyltransferase
HK440_RS03375	ENOG4105D7V	transposase
HK440_RS03395	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
HK440_RS03400	ENOG4105DWF	phosphomethylpyrimidine kinase
HK440_RS03415	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HK440_RS03420	ENOG4105C5E	polysaccharide biosynthesis protein
HK440_RS03445	ENOG410841J	DNA-binding protein Hu
HK440_RS03465	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HK440_RS03475	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HK440_RS03485	ENOG4105VFU	Rna-binding protein
HK440_RS03495	ENOG4105C3M	thioredoxin reductase
HK440_RS03500	ENOG4105K63	Thioredoxin
HK440_RS03510	ENOG4105D6E	homoserine dehydrogenase
HK440_RS03530	ENOG4108IJ8	ABC transporter
HK440_RS03535	ENOG4108HQR	Glycine betaine
HK440_RS03545	ENOG4108SEK	ompa motb domain protein
HK440_RS03550	ENOG4105E14	MotA TolQ exbB proton channel
HK440_RS03555	ENOG4105D06	uba thif-type nad fad binding protein
HK440_RS03560	ENOG4107VMB	Beta-lactamase domain protein
HK440_RS03580	ENOG4105X6C	Flagellar basal body-associated protein FliL
HK440_RS03585	ENOG410829W	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HK440_RS03605	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HK440_RS03625	ENOG4108ZEX	molybdopterin converting factor, subunit 2
HK440_RS03630	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HK440_RS03665	ENOG4105C0P	Mg chelatase subunit ChlI
HK440_RS03670	ENOG4105C59	p-type ATPase
HK440_RS03675	ENOG41082EK	Restriction modification system DNA (Specificity
HK440_RS03695	ENOG4105ZGC	lipoprotein carrier protein
HK440_RS03725	ENOG4107QIJ	Aconitate hydratase 2
HK440_RS03735	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HK440_RS03745	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HK440_RS03750	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HK440_RS03760	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HK440_RS03770	ENOG4105D00	flagellar biosynthetic protein flhB
HK440_RS03775	ENOG41080AZ	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HK440_RS03780	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HK440_RS03805	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HK440_RS03825	ENOG4105UQX	Mate efflux family protein
HK440_RS03830	ENOG4105D3Y	Na H antiporter
HK440_RS03860	ENOG4107TPX	flagellar hook-associated
HK440_RS03880	ENOG4105CAK	Cell division ATP-binding protein ftsE
HK440_RS03885	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HK440_RS03895	ENOG4105C34	Pseudouridine synthase
HK440_RS03900	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HK440_RS03910	ENOG4105CNI	cell division protein FtsW
HK440_RS03920	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HK440_RS03930	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
HK440_RS03945	ENOG4108ZAI	phosphatidylglycerophosphatase a
HK440_RS03950	ENOG4107RIH	serine-glyoxylate aminotransferase
HK440_RS03955	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
HK440_RS03995	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HK440_RS04000	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HK440_RS04015	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
HK440_RS04020	ENOG4105HDK	L-asparaginase
HK440_RS04040	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
HK440_RS04045	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HK440_RS04055	ENOG4108IUZ	ABC transporter
HK440_RS04060	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HK440_RS04085	ENOG4107V4F	S-adenosyl-l-methionine hydroxide adenosyltransferase
HK440_RS04105	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HK440_RS04125	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HK440_RS04130	ENOG41080IJ	Diacylglycerol kinase
HK440_RS04145	ENOG4105HKX	acetone carboxylase, gamma subunit
HK440_RS04150	ENOG4107TYC	hydantoinase B oxoprolinase
HK440_RS04155	ENOG4107RID	5-oxoprolinase (ATP-hydrolyzing)
HK440_RS04165	ENOG4105CRW	Short chain fatty acid transporter
HK440_RS04170	ENOG4108IIH	CoA-transferase subunit B
HK440_RS04175	ENOG4107QP7	CoA-transferase subunit A
HK440_RS04180	ENOG4105CHU	acetyl-coa acetyltransferase
HK440_RS04190	ENOG4105CE1	Ferrous iron transport protein b
HK440_RS04200	ENOG4105CN7	Flagellar biosynthetic protein FliP
HK440_RS04205	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HK440_RS04220	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HK440_RS04225	ENOG4107R5Z	Oxidoreductase domain protein
HK440_RS04230	ENOG4105HF0	Membrane
HK440_RS04240	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HK440_RS04275	ENOG4105D4P	Coproporphyrinogen iii oxidase
HK440_RS04285	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HK440_RS04295	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HK440_RS04310	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HK440_RS04320	ENOG4105DKF	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)
HK440_RS04325	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HK440_RS04330	ENOG4105DVY	radical SAM domain protein
HK440_RS04335	ENOG41090A1	ferritin
HK440_RS04340	ENOG4105EAC	phosphoserine phosphatase
HK440_RS04355	ENOG4108IJ0	Aspartate ammonia-lyase
HK440_RS04370	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HK440_RS04375	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
HK440_RS04385	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HK440_RS04425	ENOG4108P97	
HK440_RS04430	ENOG4108USZ	hydrogenase
HK440_RS04435	ENOG4105X7T	Ni Fe-hydrogenase, b-type cytochrome subunit
HK440_RS04440	ENOG4105DPX	Hydrogenase, large subunit
HK440_RS04445	ENOG4105E3S	small subunit
HK440_RS04450	ENOG4105NF4	modulator of drug activity
HK440_RS04465	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
HK440_RS04475	ENOG4105CHM	Aminotransferase
HK440_RS04490	ENOG4105C98	muts2 protein
HK440_RS04495	ENOG4105NZ8	inorganic pyro-phosphatase
HK440_RS04510	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HK440_RS04535	ENOG4108M15	ABC transporter
HK440_RS04545	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HK440_RS04585	ENOG4105I03	Flagellin
HK440_RS04595	ENOG4108N3W	hemolysin secretion protein
HK440_RS04600	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HK440_RS04605	ENOG4108JQC	penicillin-binding protein 1A
HK440_RS04630	ENOG4107QMH	DNA methylase
HK440_RS04645	ENOG4105DQU	oxidoreductase, subunit beta
HK440_RS04650	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
HK440_RS04680	ENOG4105DD5	Flagellar motor switch protein
HK440_RS04715	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HK440_RS04720	ENOG4105C3F	Signal peptidase i
HK440_RS04725	ENOG4108Z4T	Peptidase M50
HK440_RS04730	ENOG4108YZG	isomerase
HK440_RS04750	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HK440_RS04755	ENOG4105C3G	gtp-binding protein
HK440_RS04765	ENOG4105F4G	Membrane
HK440_RS04775	ENOG4108KBJ	Inner membrane protein YkgB
HK440_RS04795	ENOG4105CHR	reductase
HK440_RS04805	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HK440_RS04830	ENOG4108RWN	rrna methyltransferase
HK440_RS04835	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HK440_RS04845	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HK440_RS04860	ENOG4105C5F	glutamine synthetase
HK440_RS04935	ENOG4105CQB	FAD linked oxidase domain protein
HK440_RS04940	ENOG4105MRU	Plasminogen-binding protein
HK440_RS04950	ENOG4105E4C	Lytic transglycosylase catalytic
HK440_RS04960	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HK440_RS04965	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HK440_RS04970	ENOG4105HDD	phospholipase
HK440_RS04975	ENOG4105C8J	)-transporter
HK440_RS04980	ENOG4105C8J	)-transporter
HK440_RS04985	ENOG4107YD3	Thioesterase
HK440_RS04995	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HK440_RS05045	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HK440_RS05055	ENOG4105CJR	Integral membrane protein (MviN
HK440_RS05060	ENOG4105C8N	cysteinyl-tRNA synthetase
HK440_RS05070	ENOG4108F1U	ABC transporter
HK440_RS05075	ENOG4108I9K	permease protein
HK440_RS05080	ENOG4105E1F	short-chain dehydrogenase reductase
HK440_RS05085	ENOG4108S4H	thioesterase Superfamily protein
HK440_RS05120	ENOG4105CQS	hydrogenase expression formation protein HypD
HK440_RS05125	ENOG4105WRB	Hydrogenase assembly chaperone hypC hupF
HK440_RS05130	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
HK440_RS05145	ENOG4105C6K	Malic enzyme
HK440_RS05150	ENOG4105C6K	Malic enzyme
HK440_RS05160	ENOG4105W00	Flagellar hook capping protein
HK440_RS05165	ENOG4105BZE	flagellar hook protein, FlgE
HK440_RS05165	ENOG4105BZE	flagellar hook protein, FlgE
HK440_RS05175	ENOG4107U4J	modification
HK440_RS05215	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HK440_RS05220	ENOG4105HFZ	Membrane
HK440_RS05225	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HK440_RS05240	ENOG4105VSH	4-oxalocrotonate tautomerase
HK440_RS05250	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
HK440_RS05265	ENOG4105CTB	Polyprenyl synthetase
HK440_RS05270	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HK440_RS05285	ENOG4107XWN	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HK440_RS05315	ENOG4105E5Q	amino acid AbC transporter
HK440_RS05320	ENOG4105EAB	amino acid AbC transporter
HK440_RS05330	ENOG4105BZG	amino acid carrier protein
HK440_RS05335	ENOG4107QMZ	Dehydrogenase
HK440_RS05340	ENOG4105KME	endoribonuclease L-psp
HK440_RS05365	ENOG4107S6Z	Na H antiporter
HK440_RS05385	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HK440_RS05395	ENOG4105CEV	competence damage-inducible protein
HK440_RS05410	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HK440_RS05415	ENOG4105D3G	Pseudouridine synthase
HK440_RS05420	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HK440_RS05430	ENOG4105EGD	dinuclear metal center protein, YbgI family
HK440_RS05490	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HK440_RS05500	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HK440_RS05510	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HK440_RS05515	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HK440_RS05610	ENOG4105D7V	transposase
HK440_RS05630	ENOG4105EJX	conjugal transfer ATPase
HK440_RS05635	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HK440_RS05675	ENOG4108EHY	type IV secretion system
HK440_RS05725	ENOG4107QJE	Chromosome Partitioning Protein
HK440_RS05760	ENOG4108EU4	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HK440_RS05775	ENOG41071TK	Uncharacterised protein family (UPF0150)
HK440_RS05785	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
HK440_RS05800	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
HK440_RS05810	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HK440_RS05815	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HK440_RS05820	ENOG4105D64	Mechanosensitive ion channel
HK440_RS05850	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HK440_RS05860	ENOG4108J2R	molybdopterin oxidoreductase
HK440_RS05870	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HK440_RS05875	ENOG4105K59	histidine triad (HIT) protein
HK440_RS05885	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HK440_RS05890	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HK440_RS05900	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HK440_RS05910	ENOG4108JQ1	Dehydrogenase
HK440_RS05915	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HK440_RS05920	ENOG4105DFA	alanine racemase domain protein
HK440_RS05945	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
HK440_RS05950	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HK440_RS05960	ENOG4105C25	Primosomal protein n'
HK440_RS05985	ENOG4105D0M	Protease HtpX homolog
HK440_RS05990	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HK440_RS05995	ENOG4105D82	Glutamate dehydrogenase
HK440_RS06005	ENOG4105CRE	cytochrome C
HK440_RS06025	ENOG4107YV6	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HK440_RS06040	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HK440_RS06045	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HK440_RS06075	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HK440_RS06085	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HK440_RS06130	ENOG4105D7V	transposase
HK440_RS06145	ENOG4105EUU	Sel1 domain protein repeat-containing protein
HK440_RS06150	ENOG4108UHU	Aldolase
HK440_RS06155	ENOG4105C01	Dihydroxy-acid dehydratase
HK440_RS06160	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HK440_RS06165	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
HK440_RS06175	ENOG4105DQ4	alcohol dehydrogenase
HK440_RS06195	ENOG4105EJ5	oxidoreductase gamma subunit
HK440_RS06205	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
HK440_RS06210	ENOG4105DDK	oxidoreductase, beta subunit
HK440_RS06215	ENOG4107QTF	adenylosuccinate lyase
HK440_RS06225	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HK440_RS06250	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HK440_RS06255	ENOG4105BZE	flagellar hook protein, FlgE
HK440_RS06280	ENOG4108YZY	peptidylprolyl cis-trans isomerase
HK440_RS06290	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HK440_RS06305	ENOG4105M8F	Biopolymer transport protein exbD tolR
HK440_RS06310	ENOG4105E02	MotA TolQ exbB proton channel
HK440_RS06320	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HK440_RS06350	ENOG4105FA0	parb-like partition protein
HK440_RS06355	ENOG4107QJE	Chromosome Partitioning Protein
HK440_RS06365	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HK440_RS06405	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HK440_RS06410	ENOG4105V3S	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HK440_RS06425	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HK440_RS06430	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HK440_RS06440	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HK440_RS06455	ENOG4105II7	pyrroline-5-carboxylate reductase
HK440_RS06460	ENOG4105MZU	cell filamentation protein
HK440_RS06470	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
HK440_RS06485	ENOG4105CAY	ferredoxin--nadp reductase
HK440_RS06495	ENOG4107QP8	phosphohexose isomerase
HK440_RS06505	ENOG4105D22	carbon starvation protein
HK440_RS06510	ENOG4105E5Q	amino acid AbC transporter
HK440_RS06515	ENOG4105E5Q	amino acid AbC transporter
HK440_RS06520	ENOG4105CDA	abc transporter atp-binding protein
HK440_RS06535	ENOG4105EDR	glucose galactose transporter
HK440_RS06540	ENOG4105C7N	Xanthine uracil vitamin C permease
HK440_RS06570	ENOG4105D9N	nucleoside
HK440_RS06580	ENOG4107RDB	Major Facilitator
HK440_RS06585	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
HK440_RS06615	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HK440_RS06620	ENOG4105CUT	histidyl-tRNA synthetase
HK440_RS06635	ENOG4105CPC	Aldo Keto reductase
HK440_RS06655	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HK440_RS06680	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HK440_RS06700	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HK440_RS06725	ENOG4105BZ1	(ABC) transporter
HK440_RS06755	ENOG4105D7W	serine acetyltransferase
HK440_RS06790	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
HK440_RS06800	ENOG4105C12	Phosphoribosylglycinamide synthetase
HK440_RS06815	ENOG4105CZV	ABC transporter
HK440_RS06820	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HK440_RS06845	ENOG4105CSA	Coproporphyrinogen iii oxidase
HK440_RS06860	ENOG4105CFH	Aspartokinase
HK440_RS06875	ENOG4105EEI	dihydropteroate synthase
HK440_RS06885	ENOG4105DJP	Membrane
HK440_RS06900	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HK440_RS06915	ENOG4107YJQ	MAF-like protein
HK440_RS06940	ENOG4108UUM	single-stranded DNA-binding protein
HK440_RS06950	ENOG4108VMB	DNA polymerase III subunit delta'
HK440_RS06955	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HK440_RS06970	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
HK440_RS06975	ENOG4105E43	Extracellular solute-binding protein, family 5
HK440_RS06980	ENOG4105C31	Tryptophanyl-tRNA synthetase
HK440_RS06990	ENOG4105NU9	Preprotein translocase subunit SecG
HK440_RS07010	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HK440_RS07015	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HK440_RS07025	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HK440_RS07070	ENOG4105D65	subunit l
HK440_RS07075	ENOG4105C8S	subunit m
HK440_RS07080	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HK440_RS07090	ENOG4107QKV	phosphomannomutase
HK440_RS07120	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HK440_RS07125	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HK440_RS07130	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HK440_RS07135	ENOG4105DDQ	anthranilate synthase
HK440_RS07140	ENOG4105CRQ	synthase (Component I)
HK440_RS07155	ENOG4105M5K	heptosyltransferase
HK440_RS07165	ENOG4108YYC	ycei family
HK440_RS07170	ENOG4105ETU	transcriptional activator (TenA
HK440_RS07190	ENOG4107XDY	Nicotinamide Mononucleotide Transporter
HK440_RS07205	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HK440_RS07230	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HK440_RS07235	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HK440_RS07240	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HK440_RS07275	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HK440_RS07295	ENOG41084HJ	50s ribosomal protein l29
HK440_RS07335	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HK440_RS07365	ENOG4105C9Q	fumarate hydratase class II
HK440_RS07380	ENOG4105EP1	Efflux transporter rnd family, mfp subunit
HK440_RS07385	ENOG4108IJF	Heavy metal efflux pump, CzcA
HK440_RS07395	ENOG4108UMN	azlc family
HK440_RS07400	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HK440_RS07435	ENOG4105M8K	biopolymer transport protein
HK440_RS07440	ENOG4105M15	transport protein ExbD
HK440_RS07445	ENOG41067XB	TonB family
HK440_RS07455	ENOG4105EE5	Membrane protein terC
HK440_RS07460	ENOG4105D7N	magnesium and cobalt transport protein CorA
HK440_RS07465	ENOG4105BZA	Phosphoglycerate kinase
HK440_RS07470	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HK440_RS07480	ENOG4105E9Q	Acyl-transferase
HK440_RS07490	ENOG4105CN1	protease
HK440_RS07515	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HK440_RS07520	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HK440_RS07540	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HK440_RS07550	ENOG4105CDU	Replicative dna helicase
HK440_RS07555	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HK440_RS07570	ENOG4107QMH	DNA methylase
HK440_RS07590	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HK440_RS07610	ENOG410901F	(LipO)protein
HK440_RS07615	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HK440_RS07630	ENOG4107QMH	DNA methylase
HK440_RS07635	ENOG4107J0C	type IIi
HK440_RS07650	ENOG4107S2Z	UPF0761 membrane protein
HK440_RS07690	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HK440_RS07695	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HK440_RS07715	ENOG4105D4A	Cell wall formation (By similarity)
HK440_RS07720	ENOG4105VS8	Flagellar biosynthetic protein fliq
HK440_RS07725	ENOG4108JIR	Flagellum-specific ATP synthase
HK440_RS07740	ENOG410854I	s4 domain protein
HK440_RS07765	ENOG4105C2X	Arabinose 5-phosphate isomerase
HK440_RS07775	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HK440_RS07785	ENOG41082EK	Restriction modification system DNA (Specificity
HK440_RS07790	ENOG4105CIY	formyltetrahydrofolate deformylase
HK440_RS07835	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HK440_RS07840	ENOG41085EF	Carbon storage regulator
HK440_RS07845	ENOG4107Z7S	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HK440_RS07855	ENOG4105M8K	biopolymer transport protein
HK440_RS07860	ENOG4105M15	transport protein ExbD
HK440_RS07875	ENOG4108512	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HK440_RS07880	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HK440_RS07890	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HK440_RS07920	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
HK440_RS07925	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HK440_RS07930	ENOG4106XI8	Protein of unknown function (DUF2443)
HK440_RS07960	ENOG4105D7V	transposase