locus-tag	class	description
HK440_RS00020	COG0708	Exodeoxyribonuclease III
HK440_RS00035	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HK440_RS00070	COG0195	Participates in both transcription termination and antitermination
HK440_RS00075	COG1921	L-seryl-tRNASec selenium transferase activity
HK440_RS00095	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HK440_RS00100	COG0348	domain, Protein
HK440_RS00110	COG0786	glutamate:sodium symporter activity
HK440_RS00170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HK440_RS00175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HK440_RS00185	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HK440_RS00190	COG0306	phosphate transporter
HK440_RS00195	COG1253	flavin adenine dinucleotide binding
HK440_RS00205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HK440_RS00220	COG1739	Uncharacterized protein family UPF0029
HK440_RS00230	COG2226	methyltransferase
HK440_RS00245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HK440_RS00265	COG0163	prenyltransferase activity
HK440_RS00270	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HK440_RS00295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HK440_RS00295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HK440_RS00305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HK440_RS00315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HK440_RS00320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HK440_RS00345	COG0587	DNA-directed DNA polymerase activity
HK440_RS00350	COG1187	pseudouridine synthase activity
HK440_RS00355	COG3118	belongs to the thioredoxin family
HK440_RS00380	COG0732	type I restriction modification DNA specificity domain
HK440_RS00455	COG4962	Type ii secretion system protein e
HK440_RS00480	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HK440_RS00505	COG1192	Involved in chromosome partitioning
HK440_RS00560	COG4974	Belongs to the 'phage' integrase family
HK440_RS00575	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HK440_RS00585	COG4772	TonB-dependent receptor
HK440_RS00590	COG0010	Belongs to the arginase family
HK440_RS00595	COG0686	Belongs to the AlaDH PNT family
HK440_RS00615	COG0497	DNA recombination
HK440_RS00630	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HK440_RS00640	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HK440_RS00675	COG0723	plastoquinol--plastocyanin reductase activity
HK440_RS00680	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HK440_RS00690	COG0739	heme binding
HK440_RS00700	COG0285	dihydrofolate synthase activity
HK440_RS00710	COG0495	leucyl-tRNA aminoacylation
HK440_RS00720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HK440_RS00725	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HK440_RS00730	COG1862	Preprotein translocase
HK440_RS00735	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HK440_RS00755	COG0768	penicillin binding
HK440_RS00770	COG1558	bacterial-type flagellum-dependent cell motility
HK440_RS00780	COG0772	Belongs to the SEDS family
HK440_RS00795	COG0450	alkyl hydroperoxide reductase
HK440_RS00805	COG0768	penicillin binding
HK440_RS00830	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HK440_RS00835	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HK440_RS00840	COG0741	lytic transglycosylase activity
HK440_RS00840	COG1388	LysM domain
HK440_RS00845	COG0084	hydrolase, TatD family'
HK440_RS00850	COG0307	riboflavin synthase, alpha
HK440_RS00865	COG2011	ABC-type metal ion transport system permease component
HK440_RS00880	COG0671	phosphoesterase, PA-phosphatase related
HK440_RS00885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HK440_RS00905	COG4786	Flagellar basal body rod
HK440_RS00920	COG4735	regulation of single-species biofilm formation
HK440_RS00925	COG4735	regulation of single-species biofilm formation
HK440_RS00940	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HK440_RS00945	COG0288	reversible hydration of carbon dioxide
HK440_RS00950	COG0284	orotidine-5'-phosphate decarboxylase activity
HK440_RS01000	COG0358	DNA primase activity
HK440_RS01005	COG0482	sulfurtransferase activity
HK440_RS01040	COG0784	Response regulator, receiver
HK440_RS01040	COG0835	chemotaxis
HK440_RS01050	COG0671	phosphoesterase, PA-phosphatase related
HK440_RS01055	COG2194	sulfuric ester hydrolase activity
HK440_RS01075	COG0372	Belongs to the citrate synthase family
HK440_RS01080	COG0538	isocitrate dehydrogenase activity
HK440_RS01090	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HK440_RS01105	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HK440_RS01110	COG0542	response to heat
HK440_RS01160	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HK440_RS01180	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HK440_RS01185	COG2957	Belongs to the agmatine deiminase family
HK440_RS01200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HK440_RS01275	COG0830	nickel cation binding
HK440_RS01290	COG0804	urea catabolic process
HK440_RS01340	COG0840	transmembrane signaling receptor activity
HK440_RS01370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HK440_RS01375	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HK440_RS01380	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HK440_RS01410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HK440_RS01420	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HK440_RS01425	COG0840	transmembrane signaling receptor activity
HK440_RS01430	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HK440_RS01440	COG1216	Glycosyl transferase, family 2
HK440_RS01450	COG0737	Belongs to the 5'-nucleotidase family
HK440_RS01460	COG0626	cystathionine gamma-synthase activity
HK440_RS01465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HK440_RS01485	COG1420	regulation of RNA biosynthetic process
HK440_RS01505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HK440_RS01510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HK440_RS01510	COG0551	DNA topoisomerase type I activity
HK440_RS01515	COG0731	radical SAM domain protein
HK440_RS01525	COG0574	Belongs to the PEP-utilizing enzyme family
HK440_RS01525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HK440_RS01535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HK440_RS01565	COG1760	l-serine dehydratase
HK440_RS01570	COG0814	amino acid
HK440_RS01575	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HK440_RS01580	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HK440_RS01590	COG1139	Iron-sulfur cluster binding protein
HK440_RS01595	COG0247	lactate metabolic process
HK440_RS01600	COG1620	l-lactate permease
HK440_RS01605	COG1620	l-lactate permease
HK440_RS01610	COG1194	a g-specific adenine glycosylase
HK440_RS01615	COG0471	metal ion transport
HK440_RS01620	COG3278	Belongs to the heme-copper respiratory oxidase family
HK440_RS01670	COG0148	phosphopyruvate hydratase activity
HK440_RS01700	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HK440_RS01710	COG0113	porphobilinogen synthase activity
HK440_RS01715	COG0642	Histidine kinase
HK440_RS01720	COG0745	RESPONSE REGULATOR receiver
HK440_RS01750	COG0303	'Molybdopterin
HK440_RS01765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HK440_RS01770	COG0191	fructose-bisphosphate aldolase activity
HK440_RS01785	COG0489	protein tyrosine kinase activity
HK440_RS01825	COG0105	UTP biosynthetic process
HK440_RS01835	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HK440_RS01840	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HK440_RS01855	COG1053	succinate dehydrogenase
HK440_RS01860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HK440_RS01865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HK440_RS01900	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HK440_RS01905	COG1136	(ABC) transporter
HK440_RS01910	COG2089	acid synthase
HK440_RS01925	COG0326	Molecular chaperone. Has ATPase activity
HK440_RS01930	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HK440_RS01945	COG0471	metal ion transport
HK440_RS01950	COG0575	Belongs to the CDS family
HK440_RS01960	COG1881	PFAM PEBP family protein
HK440_RS01970	COG1104	cysteine desulfurase activity
HK440_RS01985	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HK440_RS01990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HK440_RS01990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HK440_RS01995	COG0730	response to heat
HK440_RS02005	COG0659	secondary active sulfate transmembrane transporter activity
HK440_RS02035	COG0754	glutathionylspermidine amidase activity
HK440_RS02085	COG0783	Belongs to the Dps family
HK440_RS02090	COG0642	Histidine kinase
HK440_RS02095	COG3951	Flagellar rod assembly protein muramidase FlgJ
HK440_RS02120	COG4172	Belongs to the ABC transporter superfamily
HK440_RS02160	COG0750	zinc metalloprotease
HK440_RS02210	COG0542	response to heat
HK440_RS02215	COG0785	Cytochrome C biogenesis protein
HK440_RS02220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HK440_RS02225	COG0402	S-adenosylhomocysteine deaminase activity
HK440_RS02260	COG0727	PFAM Uncharacterised protein family (UPF0153)
HK440_RS02270	COG0134	indole-3-glycerol-phosphate synthase activity
HK440_RS02280	COG0248	Ppx GppA phosphatase
HK440_RS02285	COG0859	PFAM glycosyl transferase family 9
HK440_RS02315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HK440_RS02320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HK440_RS02340	COG0019	diaminopimelate decarboxylase activity
HK440_RS02355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HK440_RS02395	COG0747	negative chemotaxis
HK440_RS02400	COG0601	transmembrane transport
HK440_RS02405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HK440_RS02410	COG0444	Belongs to the ABC transporter superfamily
HK440_RS02415	COG4608	Belongs to the ABC transporter superfamily
HK440_RS02450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HK440_RS02465	COG0523	cobalamin synthesis protein
HK440_RS02475	COG0748	coenzyme F420 binding
HK440_RS02485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HK440_RS02510	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HK440_RS02515	COG3980	spore coat polysaccharide biosynthesis protein
HK440_RS02520	COG3980	spore coat polysaccharide biosynthesis protein
HK440_RS02525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HK440_RS02530	COG1663	tetraacyldisaccharide 4'-kinase activity
HK440_RS02550	COG2894	cell division
HK440_RS02560	COG0758	DNA mediated transformation
HK440_RS02560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HK440_RS02565	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HK440_RS02570	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HK440_RS02585	COG0564	pseudouridine synthase activity
HK440_RS02590	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HK440_RS02590	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HK440_RS02595	COG0504	CTP synthase activity
HK440_RS02605	COG1766	The M ring may be actively involved in energy transduction
HK440_RS02610	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HK440_RS02620	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HK440_RS02645	COG3842	ATPase activity
HK440_RS02655	COG4786	Flagellar basal body rod
HK440_RS02660	COG0477	Major facilitator Superfamily
HK440_RS02665	COG0675	Transposase, IS605 OrfB family
HK440_RS02675	COG1674	ftsk spoiiie
HK440_RS02685	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HK440_RS02690	COG0196	riboflavin kinase activity
HK440_RS02695	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HK440_RS02715	COG1132	(ABC) transporter
HK440_RS02730	COG1106	Psort location Cytoplasmic, score
HK440_RS02740	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HK440_RS02760	COG2608	mercury ion transmembrane transporter activity
HK440_RS02765	COG2217	Heavy metal translocating P-type atpase
HK440_RS02770	COG1183	phosphatidylcholine synthase activity
HK440_RS02780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HK440_RS02785	COG2264	protein methyltransferase activity
HK440_RS02790	COG0745	RESPONSE REGULATOR receiver
HK440_RS02815	COG0357	Ribosomal RNA small subunit methyltransferase G
HK440_RS02825	COG0805	protein transport
HK440_RS02870	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HK440_RS02880	COG0083	homoserine kinase activity
HK440_RS02895	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HK440_RS02910	COG1408	metallophosphoesterase
HK440_RS02915	COG0745	RESPONSE REGULATOR receiver
HK440_RS02920	COG2404	hydrolase activity, acting on ester bonds
HK440_RS02925	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HK440_RS02930	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HK440_RS02945	COG0006	proline dipeptidase activity
HK440_RS02950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HK440_RS02955	COG1419	protein localization to endoplasmic reticulum
HK440_RS02960	COG0455	bacterial-type flagellum organization
HK440_RS02975	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HK440_RS02980	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HK440_RS02980	COG1776	CheC inhibitor of MCP methylation
HK440_RS02995	COG0735	belongs to the Fur family
HK440_RS03000	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HK440_RS03000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HK440_RS03005	COG0789	Transcriptional regulator
HK440_RS03010	COG0484	heat shock protein binding
HK440_RS03025	COG0745	RESPONSE REGULATOR receiver
HK440_RS03030	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HK440_RS03030	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HK440_RS03040	COG0833	amino acid
HK440_RS03045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HK440_RS03055	COG1028	Short-chain dehydrogenase reductase Sdr
HK440_RS03060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HK440_RS03075	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HK440_RS03245	COG2824	Alkylphosphonate utilization operon protein PhnA
HK440_RS03255	COG1749	Flagellar hook protein flgE
HK440_RS03260	COG0375	protein maturation
HK440_RS03275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HK440_RS03280	COG0756	dUTP diphosphatase activity
HK440_RS03295	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HK440_RS03305	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HK440_RS03310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HK440_RS03315	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HK440_RS03315	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HK440_RS03320	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HK440_RS03330	COG1696	Membrane protein involved in D-alanine export
HK440_RS03340	COG0488	(ABC) transporter
HK440_RS03350	COG0671	phosphoesterase, PA-phosphatase related
HK440_RS03395	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HK440_RS03400	COG0351	phosphomethylpyrimidine kinase
HK440_RS03415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HK440_RS03420	COG1086	Polysaccharide biosynthesis protein
HK440_RS03445	COG0776	regulation of translation
HK440_RS03465	COG0237	dephospho-CoA kinase activity
HK440_RS03475	COG0517	IMP dehydrogenase activity
HK440_RS03475	COG0516	GMP reductase activity
HK440_RS03485	COG0724	RNA recognition motif
HK440_RS03495	COG0492	ferredoxin-NADP+ reductase activity
HK440_RS03500	COG3118	belongs to the thioredoxin family
HK440_RS03510	COG0460	homoserine dehydrogenase
HK440_RS03530	COG0517	IMP dehydrogenase activity
HK440_RS03530	COG1125	glycine betaine transport
HK440_RS03535	COG1732	Glycine betaine
HK440_RS03545	COG1360	Flagellar Motor Protein
HK440_RS03550	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HK440_RS03555	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HK440_RS03560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HK440_RS03580	COG1580	Controls the rotational direction of flagella during chemotaxis
HK440_RS03585	COG0736	holo-[acyl-carrier-protein] synthase activity
HK440_RS03605	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HK440_RS03605	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HK440_RS03625	COG0314	molybdopterin synthase activity
HK440_RS03630	COG0521	Mo-molybdopterin cofactor biosynthetic process
HK440_RS03665	COG0606	chelatase, subunit chli
HK440_RS03670	COG2217	Heavy metal translocating P-type atpase
HK440_RS03675	COG0732	type I restriction modification DNA specificity domain
HK440_RS03695	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HK440_RS03725	COG1049	propionate catabolic process, 2-methylcitrate cycle
HK440_RS03735	COG0528	UMP kinase activity
HK440_RS03740	COG1758	RNA polymerase activity
HK440_RS03745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HK440_RS03750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HK440_RS03760	COG0860	N-Acetylmuramoyl-L-alanine amidase
HK440_RS03770	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HK440_RS03775	COG0746	molybdenum cofactor guanylyltransferase activity
HK440_RS03780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HK440_RS03805	COG0552	protein localization to endoplasmic reticulum
HK440_RS03825	COG0534	Mate efflux family protein
HK440_RS03830	COG2056	Na+-H+ antiporter family
HK440_RS03860	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HK440_RS03880	COG2884	Cell division ATP-binding protein ftsE
HK440_RS03885	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HK440_RS03895	COG0564	pseudouridine synthase activity
HK440_RS03900	COG1162	GTPase activity
HK440_RS03910	COG0772	Belongs to the SEDS family
HK440_RS03920	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HK440_RS03930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HK440_RS03945	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HK440_RS03950	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HK440_RS03955	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HK440_RS03995	COG0037	tRNA processing
HK440_RS04000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HK440_RS04015	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HK440_RS04020	COG0252	asparaginase activity
HK440_RS04040	COG1279	arginine transmembrane transporter activity
HK440_RS04045	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HK440_RS04055	COG1137	ATPase activity
HK440_RS04060	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HK440_RS04085	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HK440_RS04105	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HK440_RS04115	COG2204	response regulator
HK440_RS04125	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HK440_RS04130	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HK440_RS04145	COG4647	ligase activity
HK440_RS04150	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HK440_RS04155	COG0145	ligase activity
HK440_RS04165	COG2031	fatty acid transporter
HK440_RS04170	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HK440_RS04175	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HK440_RS04180	COG0183	Belongs to the thiolase family
HK440_RS04190	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HK440_RS04200	COG1338	Plays a role in the flagellum-specific transport system
HK440_RS04205	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HK440_RS04220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HK440_RS04230	COG0730	response to heat
HK440_RS04240	COG4974	Belongs to the 'phage' integrase family
HK440_RS04275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HK440_RS04285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HK440_RS04295	COG0328	RNA-DNA hybrid ribonuclease activity
HK440_RS04310	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HK440_RS04320	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HK440_RS04325	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HK440_RS04330	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HK440_RS04335	COG1528	Iron-storage protein
HK440_RS04340	COG0560	Phosphoserine phosphatase
HK440_RS04355	COG1027	Aspartate ammonia-lyase
HK440_RS04385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HK440_RS04425	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HK440_RS04430	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HK440_RS04435	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HK440_RS04440	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HK440_RS04445	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HK440_RS04450	COG2249	NAD(P)H dehydrogenase (quinone) activity
HK440_RS04465	COG2171	N-acyltransferase activity
HK440_RS04475	COG0436	Aminotransferase
HK440_RS04490	COG1193	negative regulation of DNA recombination
HK440_RS04495	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HK440_RS04510	COG0563	adenylate kinase activity
HK440_RS04520	COG0835	chemotaxis
HK440_RS04520	COG0784	Response regulator, receiver
HK440_RS04535	COG1131	(ABC) transporter
HK440_RS04545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HK440_RS04585	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HK440_RS04595	COG0840	transmembrane signaling receptor activity
HK440_RS04600	COG0156	8-amino-7-oxononanoate synthase activity
HK440_RS04605	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HK440_RS04645	COG1013	pyruvate-flavodoxin oxidoreductase activity
HK440_RS04650	COG0674	pyruvate-flavodoxin oxidoreductase activity
HK440_RS04650	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HK440_RS04670	COG1918	ferrous iron import across plasma membrane
HK440_RS04675	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HK440_RS04680	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HK440_RS04680	COG1776	CheC inhibitor of MCP methylation
HK440_RS04715	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HK440_RS04720	COG0681	Belongs to the peptidase S26 family
HK440_RS04725	COG1994	Peptidase M50
HK440_RS04730	COG0698	ribose 5-phosphate isomerase
HK440_RS04750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HK440_RS04755	COG0012	GTP binding
HK440_RS04765	COG0628	permease
HK440_RS04795	COG1028	Short-chain dehydrogenase reductase Sdr
HK440_RS04805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HK440_RS04830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HK440_RS04835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HK440_RS04845	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HK440_RS04860	COG0174	glutamine synthetase
HK440_RS04935	COG0277	FAD linked oxidase domain protein
HK440_RS04950	COG0741	lytic transglycosylase activity
HK440_RS04950	COG1196	nuclear chromosome segregation
HK440_RS04950	COG0739	heme binding
HK440_RS04960	COG0187	DNA topoisomerase II activity
HK440_RS04965	COG0592	DNA-directed DNA polymerase activity
HK440_RS04975	COG0733	neurotransmitter:sodium symporter activity
HK440_RS04980	COG0733	neurotransmitter:sodium symporter activity
HK440_RS04985	COG0824	Thioesterase
HK440_RS04995	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HK440_RS05045	COG0632	four-way junction helicase activity
HK440_RS05055	COG0728	peptidoglycan biosynthetic process
HK440_RS05060	COG0215	cysteine-tRNA ligase activity
HK440_RS05070	COG1120	ATPase activity
HK440_RS05075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HK440_RS05080	COG0300	oxidoreductase activity
HK440_RS05085	COG1607	acyl-coa hydrolase
HK440_RS05120	COG0409	Hydrogenase expression formation protein
HK440_RS05125	COG0298	carbon dioxide binding
HK440_RS05130	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HK440_RS05145	COG0280	phosphate acetyltransferase
HK440_RS05150	COG0280	phosphate acetyltransferase
HK440_RS05160	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HK440_RS05165	COG1749	Flagellar hook protein flgE
HK440_RS05165	COG1749	Flagellar hook protein flgE
HK440_RS05215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HK440_RS05220	COG0670	Belongs to the BI1 family
HK440_RS05225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HK440_RS05240	COG1942	4-Oxalocrotonate Tautomerase
HK440_RS05250	COG0585	pseudouridine synthase activity
HK440_RS05265	COG0142	geranyltranstransferase activity
HK440_RS05270	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HK440_RS05280	COG0720	synthase
HK440_RS05285	COG0602	queuosine metabolic process
HK440_RS05315	COG0765	amino acid transport
HK440_RS05320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HK440_RS05330	COG1115	amino acid carrier protein
HK440_RS05335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HK440_RS05340	COG0251	oxidation-reduction process
HK440_RS05365	COG1757	Na H antiporter
HK440_RS05385	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HK440_RS05395	COG1546	Belongs to the CinA family
HK440_RS05395	COG1058	Belongs to the CinA family
HK440_RS05410	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HK440_RS05415	COG0564	pseudouridine synthase activity
HK440_RS05420	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HK440_RS05420	COG1519	Transferase
HK440_RS05430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HK440_RS05450	COG1160	GTP binding
HK440_RS05490	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HK440_RS05500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HK440_RS05510	COG0849	cell division
HK440_RS05515	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HK440_RS05530	COG0668	transmembrane transport
HK440_RS05630	COG3451	type IV secretory pathway VirB4
HK440_RS05635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HK440_RS05675	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HK440_RS05700	COG3041	Addiction module toxin RelE StbE family
HK440_RS05725	COG1192	Involved in chromosome partitioning
HK440_RS05760	COG0582	viral genome integration into host DNA
HK440_RS05775	COG1598	PFAM Uncharacterised protein family UPF0150
HK440_RS05785	COG1166	arginine decarboxylase activity
HK440_RS05800	COG0500	methyltransferase
HK440_RS05810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HK440_RS05810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HK440_RS05815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HK440_RS05820	COG0668	transmembrane transport
HK440_RS05850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HK440_RS05850	COG0519	Catalyzes the synthesis of GMP from XMP
HK440_RS05870	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HK440_RS05875	COG0537	adenosine 5'-monophosphoramidase activity
HK440_RS05885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HK440_RS05885	COG0072	phenylalanine-tRNA ligase activity
HK440_RS05890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HK440_RS05900	COG1185	polyribonucleotide nucleotidyltransferase activity
HK440_RS05900	COG0539	negative regulation of cytoplasmic translation
HK440_RS05910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HK440_RS05915	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HK440_RS05920	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HK440_RS05930	COG0835	chemotaxis
HK440_RS05930	COG0784	Response regulator, receiver
HK440_RS05935	COG2198	Histidine kinase
HK440_RS05935	COG0784	Response regulator, receiver
HK440_RS05935	COG0643	Histidine kinase
HK440_RS05940	COG0835	chemotaxis
HK440_RS05945	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HK440_RS05950	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HK440_RS05960	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HK440_RS05985	COG0501	Belongs to the peptidase M48B family
HK440_RS05990	COG2890	protein-(glutamine-N5) methyltransferase activity
HK440_RS05995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HK440_RS06005	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HK440_RS06005	COG1333	cytochrome c biogenesis protein
HK440_RS06025	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HK440_RS06040	COG0511	ligase activity, forming carbon-carbon bonds
HK440_RS06045	COG0439	Biotin carboxylase
HK440_RS06075	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HK440_RS06085	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HK440_RS06145	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HK440_RS06150	COG0800	Aldolase
HK440_RS06155	COG0129	dihydroxy-acid dehydratase activity
HK440_RS06160	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HK440_RS06165	COG0363	glucosamine-6-phosphate deaminase activity
HK440_RS06175	COG1064	alcohol dehydrogenase
HK440_RS06195	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HK440_RS06205	COG0674	pyruvate-flavodoxin oxidoreductase activity
HK440_RS06210	COG1013	pyruvate-flavodoxin oxidoreductase activity
HK440_RS06215	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HK440_RS06225	COG0556	nucleotide-excision repair
HK440_RS06250	COG0405	Gamma-glutamyltransferase
HK440_RS06280	COG1047	Peptidyl-prolyl cis-trans
HK440_RS06290	COG2885	chlorophyll binding
HK440_RS06295	COG0823	Involved in the tonB-independent uptake of proteins
HK440_RS06305	COG0848	biopolymer transport protein
HK440_RS06310	COG0811	peptide transport
HK440_RS06320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HK440_RS06350	COG1475	DNA binding
HK440_RS06355	COG1192	Involved in chromosome partitioning
HK440_RS06365	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HK440_RS06405	COG0336	Belongs to the RNA methyltransferase TrmD family
HK440_RS06410	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HK440_RS06425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HK440_RS06430	COG0525	valine-tRNA ligase activity
HK440_RS06440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HK440_RS06455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HK440_RS06460	COG2184	nucleotidyltransferase activity
HK440_RS06470	COG0716	FMN binding
HK440_RS06485	COG0492	ferredoxin-NADP+ reductase activity
HK440_RS06495	COG0166	Belongs to the GPI family
HK440_RS06505	COG1966	Carbon starvation protein
HK440_RS06515	COG0765	amino acid transport
HK440_RS06520	COG1126	abc transporter atp-binding protein
HK440_RS06535	COG0738	Major facilitator superfamily
HK440_RS06540	COG2252	PERMEase
HK440_RS06570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HK440_RS06580	COG2814	Major facilitator Superfamily
HK440_RS06585	COG0037	tRNA processing
HK440_RS06590	COG0475	glutathione-regulated potassium exporter activity
HK440_RS06590	COG0569	domain protein
HK440_RS06615	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HK440_RS06620	COG0124	histidyl-tRNA synthetase
HK440_RS06635	COG0667	Aldo Keto reductase
HK440_RS06655	COG0085	RNA polymerase activity
HK440_RS06655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HK440_RS06680	COG0250	Participates in transcription elongation, termination and antitermination
HK440_RS06700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HK440_RS06725	COG1132	(ABC) transporter
HK440_RS06755	COG1045	serine acetyltransferase
HK440_RS06800	COG0151	Belongs to the GarS family
HK440_RS06815	COG1131	(ABC) transporter
HK440_RS06820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HK440_RS06845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HK440_RS06850	COG2863	cytochrome
HK440_RS06860	COG0527	aspartate kinase activity
HK440_RS06875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HK440_RS06885	COG0697	spore germination
HK440_RS06900	COG0505	Belongs to the CarA family
HK440_RS06915	COG0424	maF-like protein
HK440_RS06940	COG0629	single-stranded DNA binding
HK440_RS06950	COG1466	dna polymerase III delta subunit
HK440_RS06955	COG0557	exoribonuclease II activity
HK440_RS06960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HK440_RS06970	COG4174	ABC transporter (Permease)
HK440_RS06975	COG4166	transmembrane transport
HK440_RS06980	COG0180	Tryptophanyl-tRNA synthetase
HK440_RS06990	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HK440_RS07010	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HK440_RS07015	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HK440_RS07025	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HK440_RS07060	COG0839	Belongs to the complex I subunit 6 family
HK440_RS07070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HK440_RS07080	COG1007	ATP synthesis coupled electron transport
HK440_RS07120	COG0133	tryptophan synthase activity
HK440_RS07125	COG0135	phosphoribosylanthranilate isomerase activity
HK440_RS07125	COG0134	indole-3-glycerol-phosphate synthase activity
HK440_RS07130	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HK440_RS07135	COG0512	Glutamine amidotransferase of anthranilate synthase
HK440_RS07140	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HK440_RS07155	COG0859	PFAM glycosyl transferase family 9
HK440_RS07165	COG2353	YceI-like domain
HK440_RS07170	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HK440_RS07205	COG0202	RNA polymerase activity
HK440_RS07230	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HK440_RS07235	COG0024	Methionine aminopeptidase
HK440_RS07240	COG0201	protein transport
HK440_RS07275	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HK440_RS07295	COG0255	Belongs to the universal ribosomal protein uL29 family
HK440_RS07335	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HK440_RS07365	COG0114	fumarate hydratase activity
HK440_RS07380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HK440_RS07385	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HK440_RS07390	COG1687	branched-chain amino acid
HK440_RS07395	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HK440_RS07400	COG0484	heat shock protein binding
HK440_RS07435	COG0811	peptide transport
HK440_RS07440	COG0848	biopolymer transport protein
HK440_RS07445	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HK440_RS07455	COG0861	Integral membrane protein TerC family
HK440_RS07460	COG0598	Magnesium transport protein CorA
HK440_RS07465	COG0126	phosphoglycerate kinase activity
HK440_RS07470	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HK440_RS07480	COG0204	Acyl-transferase
HK440_RS07490	COG0793	Belongs to the peptidase S41A family
HK440_RS07515	COG0157	Belongs to the NadC ModD family
HK440_RS07520	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HK440_RS07540	COG0109	protoheme IX farnesyltransferase activity
HK440_RS07550	COG0305	Participates in initiation and elongation during chromosome replication
HK440_RS07555	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HK440_RS07555	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HK440_RS07560	COG0642	Histidine kinase
HK440_RS07565	COG0745	RESPONSE REGULATOR receiver
HK440_RS07570	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HK440_RS07585	COG1077	Cell shape determining protein MreB Mrl
HK440_RS07590	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HK440_RS07610	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HK440_RS07615	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HK440_RS07620	COG0287	Prephenate dehydrogenase
HK440_RS07630	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HK440_RS07635	COG3421	Type III restriction
HK440_RS07650	COG1295	ribonuclease BN
HK440_RS07690	COG0799	negative regulation of ribosome biogenesis
HK440_RS07695	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HK440_RS07715	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HK440_RS07720	COG1987	bacterial-type flagellum assembly
HK440_RS07725	COG1157	protein secretion by the type III secretion system
HK440_RS07730	COG4962	Type ii secretion system protein e
HK440_RS07740	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HK440_RS07765	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HK440_RS07765	COG0517	IMP dehydrogenase activity
HK440_RS07775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HK440_RS07785	COG0732	type I restriction modification DNA specificity domain
HK440_RS07790	COG0788	formyltetrahydrofolate deformylase activity
HK440_RS07835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HK440_RS07840	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HK440_RS07845	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HK440_RS07855	COG0811	peptide transport
HK440_RS07860	COG0848	biopolymer transport protein
HK440_RS07875	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HK440_RS07880	COG0706	membrane insertase activity
HK440_RS07890	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HK440_RS07920	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HK440_RS07925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HK440_RS07945	COG3177	Filamentation induced by cAMP protein fic