locus-tag	class	description
HG574_RS00015	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HG574_RS00020	COG0288	reversible hydration of carbon dioxide
HG574_RS00025	COG0284	orotidine-5'-phosphate decarboxylase activity
HG574_RS00070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HG574_RS00075	COG0358	DNA primase activity
HG574_RS00080	COG0482	sulfurtransferase activity
HG574_RS00115	COG0784	Response regulator, receiver
HG574_RS00115	COG0835	chemotaxis
HG574_RS00125	COG0671	phosphoesterase, PA-phosphatase related
HG574_RS00130	COG2194	sulfuric ester hydrolase activity
HG574_RS00140	COG0372	Belongs to the citrate synthase family
HG574_RS00145	COG0538	isocitrate dehydrogenase activity
HG574_RS00155	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HG574_RS00180	COG1598	PFAM Uncharacterised protein family UPF0150
HG574_RS00185	COG0589	response to stress
HG574_RS00190	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HG574_RS00195	COG0542	response to heat
HG574_RS00200	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HG574_RS00265	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HG574_RS00270	COG2957	Belongs to the agmatine deiminase family
HG574_RS00300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG574_RS00385	COG0804	urea catabolic process
HG574_RS00390	COG0831	urea catabolic process
HG574_RS00390	COG0832	Belongs to the urease beta subunit family
HG574_RS00410	COG0268	Binds directly to 16S ribosomal RNA
HG574_RS00435	COG0840	transmembrane signaling receptor activity
HG574_RS00465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG574_RS00470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HG574_RS00475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HG574_RS00505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG574_RS00515	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HG574_RS00520	COG0840	transmembrane signaling receptor activity
HG574_RS00525	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HG574_RS00535	COG1216	Glycosyl transferase, family 2
HG574_RS00545	COG0737	Belongs to the 5'-nucleotidase family
HG574_RS00555	COG0626	cystathionine gamma-synthase activity
HG574_RS00560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HG574_RS00580	COG1420	regulation of RNA biosynthetic process
HG574_RS00600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HG574_RS00610	COG0731	radical SAM domain protein
HG574_RS00620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HG574_RS00620	COG0574	Belongs to the PEP-utilizing enzyme family
HG574_RS00630	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HG574_RS00640	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HG574_RS00660	COG1760	l-serine dehydratase
HG574_RS00665	COG0814	amino acid
HG574_RS00670	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HG574_RS00675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG574_RS00685	COG1139	Iron-sulfur cluster binding protein
HG574_RS00690	COG0247	lactate metabolic process
HG574_RS00695	COG1620	l-lactate permease
HG574_RS00700	COG1620	l-lactate permease
HG574_RS00705	COG1194	a g-specific adenine glycosylase
HG574_RS00710	COG0471	metal ion transport
HG574_RS00715	COG3278	Belongs to the heme-copper respiratory oxidase family
HG574_RS00765	COG0148	phosphopyruvate hydratase activity
HG574_RS00795	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG574_RS00800	COG0217	transcriptional regulatory protein
HG574_RS00805	COG0113	porphobilinogen synthase activity
HG574_RS00815	COG0745	RESPONSE REGULATOR receiver
HG574_RS00830	COG0826	peptidase U32
HG574_RS00845	COG0303	'Molybdopterin
HG574_RS00860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HG574_RS00865	COG0191	fructose-bisphosphate aldolase activity
HG574_RS00870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HG574_RS00890	COG2089	acid synthase
HG574_RS00895	COG1136	(ABC) transporter
HG574_RS00900	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HG574_RS00930	COG2862	Uncharacterized protein family, UPF0114
HG574_RS00935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HG574_RS00940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HG574_RS00945	COG1053	succinate dehydrogenase
HG574_RS00955	COG0149	triose-phosphate isomerase activity
HG574_RS00960	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HG574_RS00995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HG574_RS01015	COG0489	protein tyrosine kinase activity
HG574_RS01030	COG0326	Molecular chaperone. Has ATPase activity
HG574_RS01035	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG574_RS01045	COG0445	tRNA wobble uridine modification
HG574_RS01050	COG0471	metal ion transport
HG574_RS01055	COG0575	Belongs to the CDS family
HG574_RS01060	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HG574_RS01070	COG1881	PFAM PEBP family protein
HG574_RS01095	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HG574_RS01100	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG574_RS01100	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG574_RS01105	COG0730	response to heat
HG574_RS01115	COG0659	secondary active sulfate transmembrane transporter activity
HG574_RS01145	COG0754	glutathionylspermidine amidase activity
HG574_RS01155	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG574_RS01195	COG0783	Belongs to the Dps family
HG574_RS01200	COG0642	Histidine kinase
HG574_RS01205	COG3951	Flagellar rod assembly protein muramidase FlgJ
HG574_RS01230	COG4172	Belongs to the ABC transporter superfamily
HG574_RS01235	COG4239	(ABC) transporter, permease
HG574_RS01270	COG0750	zinc metalloprotease
HG574_RS01275	COG1570	exodeoxyribonuclease VII activity
HG574_RS01300	COG0542	response to heat
HG574_RS01305	COG0785	Cytochrome C biogenesis protein
HG574_RS01310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HG574_RS01315	COG0402	S-adenosylhomocysteine deaminase activity
HG574_RS01350	COG0727	PFAM Uncharacterised protein family (UPF0153)
HG574_RS01360	COG0134	indole-3-glycerol-phosphate synthase activity
HG574_RS01370	COG0248	Ppx GppA phosphatase
HG574_RS01375	COG0859	PFAM glycosyl transferase family 9
HG574_RS01405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HG574_RS01410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG574_RS01430	COG0019	diaminopimelate decarboxylase activity
HG574_RS01445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG574_RS01470	COG0747	negative chemotaxis
HG574_RS01475	COG0601	transmembrane transport
HG574_RS01480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HG574_RS01485	COG0444	Belongs to the ABC transporter superfamily
HG574_RS01490	COG4608	Belongs to the ABC transporter superfamily
HG574_RS01530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG574_RS01535	COG0726	polysaccharide deacetylase
HG574_RS01555	COG0523	cobalamin synthesis protein
HG574_RS01565	COG0748	coenzyme F420 binding
HG574_RS01575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HG574_RS01600	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HG574_RS01605	COG3980	spore coat polysaccharide biosynthesis protein
HG574_RS01610	COG3980	spore coat polysaccharide biosynthesis protein
HG574_RS01615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HG574_RS01620	COG1663	tetraacyldisaccharide 4'-kinase activity
HG574_RS01640	COG2894	cell division
HG574_RS01645	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HG574_RS01650	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HG574_RS01650	COG0758	DNA mediated transformation
HG574_RS01660	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG574_RS01675	COG0564	pseudouridine synthase activity
HG574_RS01680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HG574_RS01680	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HG574_RS01685	COG0504	CTP synthase activity
HG574_RS01695	COG1766	The M ring may be actively involved in energy transduction
HG574_RS01700	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG574_RS01710	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HG574_RS01735	COG4786	Flagellar basal body rod
HG574_RS01740	COG0477	Major facilitator Superfamily
HG574_RS01745	COG1674	ftsk spoiiie
HG574_RS01755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HG574_RS01760	COG0196	riboflavin kinase activity
HG574_RS01765	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HG574_RS01785	COG1132	(ABC) transporter
HG574_RS01800	COG1106	Psort location Cytoplasmic, score
HG574_RS01810	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HG574_RS01830	COG2608	mercury ion transmembrane transporter activity
HG574_RS01840	COG1183	phosphatidylcholine synthase activity
HG574_RS01850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG574_RS01855	COG2264	protein methyltransferase activity
HG574_RS01860	COG0745	RESPONSE REGULATOR receiver
HG574_RS01885	COG0357	Ribosomal RNA small subunit methyltransferase G
HG574_RS01895	COG0805	protein transport
HG574_RS01910	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HG574_RS01950	COG0083	homoserine kinase activity
HG574_RS01980	COG1408	metallophosphoesterase
HG574_RS01985	COG0745	RESPONSE REGULATOR receiver
HG574_RS01990	COG2404	hydrolase activity, acting on ester bonds
HG574_RS01995	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG574_RS02000	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HG574_RS02015	COG0006	proline dipeptidase activity
HG574_RS02020	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HG574_RS02025	COG1419	protein localization to endoplasmic reticulum
HG574_RS02030	COG0455	bacterial-type flagellum organization
HG574_RS02045	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG574_RS02050	COG1776	CheC inhibitor of MCP methylation
HG574_RS02050	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG574_RS02065	COG0735	belongs to the Fur family
HG574_RS02070	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG574_RS02070	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HG574_RS02075	COG0789	Transcriptional regulator
HG574_RS02080	COG0484	heat shock protein binding
HG574_RS02095	COG0745	RESPONSE REGULATOR receiver
HG574_RS02100	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HG574_RS02100	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HG574_RS02110	COG0833	amino acid
HG574_RS02115	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HG574_RS02125	COG1028	Short-chain dehydrogenase reductase Sdr
HG574_RS02130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG574_RS02140	COG0167	dihydroorotate dehydrogenase activity
HG574_RS02145	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HG574_RS02175	COG4974	Belongs to the 'phage' integrase family
HG574_RS02230	COG1192	Involved in chromosome partitioning
HG574_RS02275	COG1598	PFAM Uncharacterised protein family UPF0150
HG574_RS02375	COG1217	gtp-binding protein TYPA
HG574_RS02445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HG574_RS02450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HG574_RS02460	COG0824	Thioesterase
HG574_RS02465	COG0733	neurotransmitter:sodium symporter activity
HG574_RS02470	COG0733	neurotransmitter:sodium symporter activity
HG574_RS02480	COG0592	DNA-directed DNA polymerase activity
HG574_RS02485	COG0187	DNA topoisomerase II activity
HG574_RS02560	COG0174	glutamine synthetase
HG574_RS02685	COG3451	type IV secretory pathway VirB4
HG574_RS02710	COG0277	FAD linked oxidase domain protein
HG574_RS02725	COG1196	nuclear chromosome segregation
HG574_RS02725	COG0741	lytic transglycosylase activity
HG574_RS02725	COG0739	heme binding
HG574_RS02745	COG1842	Phage shock protein A
HG574_RS02765	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HG574_RS02775	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HG574_RS02805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG574_RS02815	COG1028	Short-chain dehydrogenase reductase Sdr
HG574_RS02840	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HG574_RS02845	COG0628	permease
HG574_RS02855	COG0012	GTP binding
HG574_RS02860	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HG574_RS02880	COG0698	ribose 5-phosphate isomerase
HG574_RS02885	COG1994	Peptidase M50
HG574_RS02890	COG0681	Belongs to the peptidase S26 family
HG574_RS02930	COG1776	CheC inhibitor of MCP methylation
HG574_RS02930	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG574_RS02935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HG574_RS02940	COG1918	ferrous iron import across plasma membrane
HG574_RS02960	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HG574_RS02960	COG0674	pyruvate-flavodoxin oxidoreductase activity
HG574_RS02965	COG1013	pyruvate-flavodoxin oxidoreductase activity
HG574_RS03000	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HG574_RS03005	COG0156	8-amino-7-oxononanoate synthase activity
HG574_RS03010	COG0840	transmembrane signaling receptor activity
HG574_RS03020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HG574_RS03070	COG1131	(ABC) transporter
HG574_RS03085	COG0835	chemotaxis
HG574_RS03085	COG0784	Response regulator, receiver
HG574_RS03100	COG3306	glycosyltransferase involved in LPS biosynthesis
HG574_RS03115	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HG574_RS03120	COG1193	negative regulation of DNA recombination
HG574_RS03135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HG574_RS03145	COG2171	N-acyltransferase activity
HG574_RS03160	COG2249	NAD(P)H dehydrogenase (quinone) activity
HG574_RS03165	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HG574_RS03170	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HG574_RS03175	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HG574_RS03180	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HG574_RS03185	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HG574_RS03205	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HG574_RS03210	COG0617	tRNA 3'-terminal CCA addition
HG574_RS03235	COG1598	PFAM Uncharacterised protein family UPF0150
HG574_RS03250	COG0778	Nitroreductase
HG574_RS03260	COG0762	integral membrane protein
HG574_RS03285	COG1027	Aspartate ammonia-lyase
HG574_RS03300	COG0560	Phosphoserine phosphatase
HG574_RS03305	COG1528	Iron-storage protein
HG574_RS03310	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HG574_RS03315	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HG574_RS03320	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HG574_RS03330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HG574_RS03345	COG0328	RNA-DNA hybrid ribonuclease activity
HG574_RS03365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG574_RS03405	COG4974	Belongs to the 'phage' integrase family
HG574_RS03415	COG0730	response to heat
HG574_RS03425	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG574_RS03440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HG574_RS03445	COG1338	Plays a role in the flagellum-specific transport system
HG574_RS03455	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HG574_RS03475	COG4647	ligase activity
HG574_RS03480	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HG574_RS03485	COG0145	ligase activity
HG574_RS03495	COG2031	fatty acid transporter
HG574_RS03500	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HG574_RS03505	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HG574_RS03510	COG0183	Belongs to the thiolase family
HG574_RS03520	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HG574_RS03525	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HG574_RS03535	COG2204	response regulator
HG574_RS03540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HG574_RS03550	COG0275	rRNA processing
HG574_RS03560	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HG574_RS03575	COG3177	Filamentation induced by cAMP protein fic
HG574_RS03580	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HG574_RS03585	COG1137	ATPase activity
HG574_RS03595	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HG574_RS03600	COG1279	arginine transmembrane transporter activity
HG574_RS03620	COG0252	asparaginase activity
HG574_RS03625	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HG574_RS03640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG574_RS03645	COG0037	tRNA processing
HG574_RS03675	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HG574_RS03680	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HG574_RS03685	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HG574_RS03700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HG574_RS03710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG574_RS03720	COG0772	Belongs to the SEDS family
HG574_RS03730	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HG574_RS03735	COG0564	pseudouridine synthase activity
HG574_RS03745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HG574_RS03750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HG574_RS03770	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HG574_RS03785	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HG574_RS03800	COG2056	Na+-H+ antiporter family
HG574_RS03805	COG0534	Mate efflux family protein
HG574_RS03825	COG0552	protein localization to endoplasmic reticulum
HG574_RS03845	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HG574_RS03855	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG574_RS03865	COG0860	N-Acetylmuramoyl-L-alanine amidase
HG574_RS03875	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HG574_RS03880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HG574_RS03885	COG1758	RNA polymerase activity
HG574_RS03890	COG0528	UMP kinase activity
HG574_RS03900	COG1049	propionate catabolic process, 2-methylcitrate cycle
HG574_RS03955	COG2217	Heavy metal translocating P-type atpase
HG574_RS03960	COG0606	chelatase, subunit chli
HG574_RS03975	COG0544	peptidyl-prolyl cis-trans isomerase activity
HG574_RS03990	COG0315	cyclic pyranopterin monophosphate synthase activity
HG574_RS03995	COG0521	Mo-molybdopterin cofactor biosynthetic process
HG574_RS04000	COG0314	molybdopterin synthase activity
HG574_RS04020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG574_RS04020	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG574_RS04040	COG0736	holo-[acyl-carrier-protein] synthase activity
HG574_RS04045	COG1580	Controls the rotational direction of flagella during chemotaxis
HG574_RS04065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG574_RS04070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HG574_RS04075	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HG574_RS04080	COG1360	Flagellar Motor Protein
HG574_RS04095	COG0517	IMP dehydrogenase activity
HG574_RS04095	COG1125	glycine betaine transport
HG574_RS04110	COG0322	excinuclease ABC activity
HG574_RS04115	COG0460	homoserine dehydrogenase
HG574_RS04125	COG3118	belongs to the thioredoxin family
HG574_RS04130	COG0492	ferredoxin-NADP+ reductase activity
HG574_RS04140	COG0724	RNA recognition motif
HG574_RS04150	COG0516	GMP reductase activity
HG574_RS04150	COG0517	IMP dehydrogenase activity
HG574_RS04160	COG0237	dephospho-CoA kinase activity
HG574_RS04180	COG0776	regulation of translation
HG574_RS04205	COG1086	Polysaccharide biosynthesis protein
HG574_RS04210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HG574_RS04220	COG0352	thiamine-phosphate diphosphorylase activity
HG574_RS04225	COG0351	phosphomethylpyrimidine kinase
HG574_RS04240	COG0732	type I restriction modification DNA specificity domain
HG574_RS04250	COG0671	phosphoesterase, PA-phosphatase related
HG574_RS04265	COG0488	(ABC) transporter
HG574_RS04285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG574_RS04290	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HG574_RS04300	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HG574_RS04315	COG0756	dUTP diphosphatase activity
HG574_RS04335	COG0375	protein maturation
HG574_RS04340	COG1749	Flagellar hook protein flgE
HG574_RS04345	COG2134	cdp-diacylglycerol pyrophosphatase
HG574_RS04350	COG2824	Alkylphosphonate utilization operon protein PhnA
HG574_RS04365	COG0753	catalase activity
HG574_RS04395	COG0632	four-way junction helicase activity
HG574_RS04405	COG0728	peptidoglycan biosynthetic process
HG574_RS04410	COG0215	cysteine-tRNA ligase activity
HG574_RS04425	COG1120	ATPase activity
HG574_RS04430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HG574_RS04435	COG0300	oxidoreductase activity
HG574_RS04440	COG1607	acyl-coa hydrolase
HG574_RS04460	COG3041	Addiction module toxin RelE StbE family
HG574_RS04500	COG0409	Hydrogenase expression formation protein
HG574_RS04505	COG0409	Hydrogenase expression formation protein
HG574_RS04510	COG0298	carbon dioxide binding
HG574_RS04515	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HG574_RS04535	COG0280	phosphate acetyltransferase
HG574_RS04545	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HG574_RS04550	COG1749	Flagellar hook protein flgE
HG574_RS04550	COG1749	Flagellar hook protein flgE
HG574_RS04595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HG574_RS04600	COG0670	Belongs to the BI1 family
HG574_RS04605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG574_RS04620	COG1942	4-Oxalocrotonate Tautomerase
HG574_RS04635	COG0501	Belongs to the peptidase M48B family
HG574_RS04645	COG0142	geranyltranstransferase activity
HG574_RS04650	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HG574_RS04660	COG0720	synthase
HG574_RS04665	COG0602	queuosine metabolic process
HG574_RS04680	COG0477	Major facilitator Superfamily
HG574_RS04695	COG0765	amino acid transport
HG574_RS04700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HG574_RS04705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HG574_RS04710	COG1115	amino acid carrier protein
HG574_RS04715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG574_RS04720	COG0251	oxidation-reduction process
HG574_RS04745	COG1757	Na H antiporter
HG574_RS04765	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HG574_RS04775	COG1546	Belongs to the CinA family
HG574_RS04775	COG1058	Belongs to the CinA family
HG574_RS04790	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HG574_RS04795	COG0564	pseudouridine synthase activity
HG574_RS04800	COG1519	Transferase
HG574_RS04810	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HG574_RS04815	COG0752	glycyl-tRNA synthetase alpha subunit
HG574_RS04820	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HG574_RS04830	COG1160	GTP binding
HG574_RS04835	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HG574_RS04870	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HG574_RS04880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HG574_RS04890	COG0849	cell division
HG574_RS04895	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HG574_RS04900	COG0668	transmembrane transport
HG574_RS04935	COG1166	arginine decarboxylase activity
HG574_RS04950	COG0500	methyltransferase
HG574_RS04960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG574_RS04960	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG574_RS04965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HG574_RS04970	COG0668	transmembrane transport
HG574_RS05020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG574_RS05025	COG0537	adenosine 5'-monophosphoramidase activity
HG574_RS05035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG574_RS05035	COG0072	phenylalanine-tRNA ligase activity
HG574_RS05040	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HG574_RS05050	COG1185	polyribonucleotide nucleotidyltransferase activity
HG574_RS05050	COG0539	negative regulation of cytoplasmic translation
HG574_RS05060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HG574_RS05065	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HG574_RS05070	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HG574_RS05080	COG0835	chemotaxis
HG574_RS05080	COG0784	Response regulator, receiver
HG574_RS05085	COG2198	Histidine kinase
HG574_RS05085	COG0784	Response regulator, receiver
HG574_RS05085	COG0643	Histidine kinase
HG574_RS05090	COG0835	chemotaxis
HG574_RS05095	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HG574_RS05100	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HG574_RS05110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HG574_RS05135	COG0501	Belongs to the peptidase M48B family
HG574_RS05140	COG2890	protein-(glutamine-N5) methyltransferase activity
HG574_RS05145	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HG574_RS05155	COG1333	cytochrome c biogenesis protein
HG574_RS05155	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HG574_RS05165	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HG574_RS05175	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HG574_RS05190	COG0511	ligase activity, forming carbon-carbon bonds
HG574_RS05195	COG0439	Biotin carboxylase
HG574_RS05215	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HG574_RS05225	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG574_RS05240	COG0101	tRNA pseudouridine synthase activity
HG574_RS05265	COG4221	oxidoreductase activity
HG574_RS05270	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG574_RS05275	COG0800	Aldolase
HG574_RS05280	COG0129	dihydroxy-acid dehydratase activity
HG574_RS05285	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HG574_RS05290	COG0363	glucosamine-6-phosphate deaminase activity
HG574_RS05300	COG1064	alcohol dehydrogenase
HG574_RS05325	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HG574_RS05335	COG0674	pyruvate-flavodoxin oxidoreductase activity
HG574_RS05340	COG1013	pyruvate-flavodoxin oxidoreductase activity
HG574_RS05345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HG574_RS05355	COG0556	nucleotide-excision repair
HG574_RS05375	COG0405	Gamma-glutamyltransferase
HG574_RS05405	COG1047	Peptidyl-prolyl cis-trans
HG574_RS05415	COG2885	chlorophyll binding
HG574_RS05420	COG0823	Involved in the tonB-independent uptake of proteins
HG574_RS05430	COG0848	biopolymer transport protein
HG574_RS05435	COG0811	peptide transport
HG574_RS05440	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HG574_RS05450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HG574_RS05475	COG1475	DNA binding
HG574_RS05480	COG1192	Involved in chromosome partitioning
HG574_RS05490	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HG574_RS05525	COG0336	Belongs to the RNA methyltransferase TrmD family
HG574_RS05530	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HG574_RS05545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HG574_RS05550	COG0525	valine-tRNA ligase activity
HG574_RS05575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HG574_RS05580	COG2184	nucleotidyltransferase activity
HG574_RS05590	COG0716	FMN binding
HG574_RS05605	COG0492	ferredoxin-NADP+ reductase activity
HG574_RS05625	COG1966	Carbon starvation protein
HG574_RS05635	COG0765	amino acid transport
HG574_RS05640	COG1126	abc transporter atp-binding protein
HG574_RS05655	COG0738	Major facilitator superfamily
HG574_RS05660	COG2252	PERMEase
HG574_RS05680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HG574_RS05690	COG2814	Major facilitator Superfamily
HG574_RS05695	COG0037	tRNA processing
HG574_RS05700	COG0475	glutathione-regulated potassium exporter activity
HG574_RS05700	COG0569	domain protein
HG574_RS05745	COG0124	histidyl-tRNA synthetase
HG574_RS05750	COG0859	PFAM glycosyl transferase family 9
HG574_RS05760	COG0667	Aldo Keto reductase
HG574_RS05765	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG574_RS05780	COG0085	RNA polymerase activity
HG574_RS05780	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HG574_RS05805	COG0250	Participates in transcription elongation, termination and antitermination
HG574_RS05850	COG1132	(ABC) transporter
HG574_RS05875	COG1045	serine acetyltransferase
HG574_RS05905	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HG574_RS05915	COG0151	Belongs to the GarS family
HG574_RS05930	COG1131	(ABC) transporter
HG574_RS05935	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HG574_RS05955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HG574_RS05960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG574_RS05965	COG2863	cytochrome
HG574_RS05975	COG0527	aspartate kinase activity
HG574_RS05990	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HG574_RS06000	COG0697	spore germination
HG574_RS06015	COG0505	Belongs to the CarA family
HG574_RS06035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HG574_RS06055	COG0629	single-stranded DNA binding
HG574_RS06065	COG1466	dna polymerase III delta subunit
HG574_RS06070	COG0557	exoribonuclease II activity
HG574_RS06085	COG4174	ABC transporter (Permease)
HG574_RS06090	COG4166	transmembrane transport
HG574_RS06095	COG0180	Tryptophanyl-tRNA synthetase
HG574_RS06105	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HG574_RS06110	COG0233	cytoplasmic translational termination
HG574_RS06125	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG574_RS06130	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG574_RS06140	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG574_RS06165	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HG574_RS06175	COG0839	Belongs to the complex I subunit 6 family
HG574_RS06185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HG574_RS06195	COG1007	ATP synthesis coupled electron transport
HG574_RS06220	COG0133	tryptophan synthase activity
HG574_RS06225	COG0135	phosphoribosylanthranilate isomerase activity
HG574_RS06225	COG0134	indole-3-glycerol-phosphate synthase activity
HG574_RS06230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HG574_RS06235	COG0512	Glutamine amidotransferase of anthranilate synthase
HG574_RS06240	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG574_RS06245	COG0859	PFAM glycosyl transferase family 9
HG574_RS06255	COG2353	YceI-like domain
HG574_RS06260	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HG574_RS06290	COG0202	RNA polymerase activity
HG574_RS06315	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HG574_RS06320	COG0024	Methionine aminopeptidase
HG574_RS06325	COG0201	protein transport
HG574_RS06340	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HG574_RS06345	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HG574_RS06360	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG574_RS06365	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HG574_RS06395	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HG574_RS06415	COG0088	Forms part of the polypeptide exit tunnel
HG574_RS06420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HG574_RS06450	COG0114	fumarate hydratase activity
HG574_RS06465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG574_RS06475	COG1687	branched-chain amino acid
HG574_RS06480	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HG574_RS06485	COG0484	heat shock protein binding
HG574_RS06500	COG0482	sulfurtransferase activity
HG574_RS06515	COG0864	Transcriptional regulator
HG574_RS06520	COG0811	peptide transport
HG574_RS06525	COG0848	biopolymer transport protein
HG574_RS06530	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HG574_RS06540	COG0861	Integral membrane protein TerC family
HG574_RS06545	COG0598	Magnesium transport protein CorA
HG574_RS06550	COG0126	phosphoglycerate kinase activity
HG574_RS06555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG574_RS06570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HG574_RS06575	COG0204	Acyl-transferase
HG574_RS06585	COG0793	Belongs to the peptidase S41A family
HG574_RS06605	COG0157	Belongs to the NadC ModD family
HG574_RS06610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HG574_RS06630	COG0109	protoheme IX farnesyltransferase activity
HG574_RS06640	COG0305	Participates in initiation and elongation during chromosome replication
HG574_RS06645	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HG574_RS06645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HG574_RS06650	COG0642	Histidine kinase
HG574_RS06655	COG0745	RESPONSE REGULATOR receiver
HG574_RS06660	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HG574_RS06670	COG1792	Involved in formation and maintenance of cell shape
HG574_RS06675	COG1077	Cell shape determining protein MreB Mrl
HG574_RS06680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HG574_RS06695	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HG574_RS06705	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HG574_RS06710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HG574_RS06715	COG0287	Prephenate dehydrogenase
HG574_RS06725	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HG574_RS06740	COG1295	ribonuclease BN
HG574_RS06775	COG0799	negative regulation of ribosome biogenesis
HG574_RS06780	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HG574_RS06800	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HG574_RS06805	COG1987	bacterial-type flagellum assembly
HG574_RS06810	COG1157	protein secretion by the type III secretion system
HG574_RS06815	COG4962	Type ii secretion system protein e
HG574_RS06825	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HG574_RS06845	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HG574_RS06850	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HG574_RS06855	COG0517	IMP dehydrogenase activity
HG574_RS06855	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HG574_RS06875	COG0788	formyltetrahydrofolate deformylase activity
HG574_RS06880	COG0616	signal peptide processing
HG574_RS06915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG574_RS06920	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG574_RS06925	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HG574_RS06930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HG574_RS06935	COG0811	peptide transport
HG574_RS06940	COG0848	biopolymer transport protein
HG574_RS06955	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HG574_RS06960	COG0706	membrane insertase activity
HG574_RS06970	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG574_RS07000	COG3118	belongs to the thioredoxin family
HG574_RS07005	COG1187	pseudouridine synthase activity
HG574_RS07010	COG0587	DNA-directed DNA polymerase activity
HG574_RS07035	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HG574_RS07040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HG574_RS07050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HG574_RS07060	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG574_RS07060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG574_RS07095	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HG574_RS07100	COG0163	prenyltransferase activity
HG574_RS07110	COG0210	DNA helicase
HG574_RS07120	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HG574_RS07135	COG2226	methyltransferase
HG574_RS07140	COG1981	membrane
HG574_RS07145	COG1739	Uncharacterized protein family UPF0029
HG574_RS07160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG574_RS07170	COG1253	flavin adenine dinucleotide binding
HG574_RS07175	COG0306	phosphate transporter
HG574_RS07180	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HG574_RS07190	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HG574_RS07200	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HG574_RS07245	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HG574_RS07255	COG0786	glutamate:sodium symporter activity
HG574_RS07265	COG0348	domain, Protein
HG574_RS07270	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HG574_RS07295	COG0195	Participates in both transcription termination and antitermination
HG574_RS07330	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HG574_RS07345	COG0708	Exodeoxyribonuclease III
HG574_RS07360	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HG574_RS07375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HG574_RS07380	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HG574_RS07400	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HG574_RS07415	COG0010	Belongs to the arginase family
HG574_RS07420	COG0833	amino acid
HG574_RS07425	COG0686	Belongs to the AlaDH PNT family
HG574_RS07445	COG0497	DNA recombination
HG574_RS07460	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG574_RS07465	COG2176	DNA-directed DNA polymerase activity
HG574_RS07470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HG574_RS07475	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HG574_RS07505	COG1074	ATP-dependent DNA helicase activity
HG574_RS07510	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HG574_RS07515	COG1862	Preprotein translocase
HG574_RS07520	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HG574_RS07525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HG574_RS07545	COG0285	dihydrofolate synthase activity
HG574_RS07555	COG0739	heme binding
HG574_RS07565	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HG574_RS07570	COG0723	plastoquinol--plastocyanin reductase activity
HG574_RS07595	COG0768	penicillin binding
HG574_RS07610	COG1558	bacterial-type flagellum-dependent cell motility
HG574_RS07620	COG0772	Belongs to the SEDS family
HG574_RS07635	COG0450	alkyl hydroperoxide reductase
HG574_RS07645	COG0768	penicillin binding
HG574_RS07670	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HG574_RS07675	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HG574_RS07680	COG0741	lytic transglycosylase activity
HG574_RS07680	COG1388	LysM domain
HG574_RS07685	COG0084	hydrolase, TatD family'
HG574_RS07690	COG0307	riboflavin synthase, alpha
HG574_RS07705	COG2011	ABC-type metal ion transport system permease component
HG574_RS07715	COG0671	phosphoesterase, PA-phosphatase related
HG574_RS07720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HG574_RS07740	COG4786	Flagellar basal body rod
HG574_RS07755	COG4735	regulation of single-species biofilm formation