locus-tag	class	description
HG576_RS00015	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HG576_RS00020	COG0288	reversible hydration of carbon dioxide
HG576_RS00025	COG0284	orotidine-5'-phosphate decarboxylase activity
HG576_RS00070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HG576_RS00075	COG0358	DNA primase activity
HG576_RS00080	COG0482	sulfurtransferase activity
HG576_RS00115	COG0835	chemotaxis
HG576_RS00115	COG0784	Response regulator, receiver
HG576_RS00125	COG0671	phosphoesterase, PA-phosphatase related
HG576_RS00130	COG2194	sulfuric ester hydrolase activity
HG576_RS00145	COG0372	Belongs to the citrate synthase family
HG576_RS00150	COG0538	isocitrate dehydrogenase activity
HG576_RS00170	COG0589	response to stress
HG576_RS00175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HG576_RS00180	COG0542	response to heat
HG576_RS00185	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HG576_RS00230	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HG576_RS00250	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HG576_RS00255	COG2957	Belongs to the agmatine deiminase family
HG576_RS00270	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG576_RS00275	COG0506	proline dehydrogenase activity
HG576_RS00275	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HG576_RS00275	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HG576_RS00345	COG1674	ftsk spoiiie
HG576_RS00375	COG0804	urea catabolic process
HG576_RS00380	COG0832	Belongs to the urease beta subunit family
HG576_RS00380	COG0831	urea catabolic process
HG576_RS00435	COG0840	transmembrane signaling receptor activity
HG576_RS00465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG576_RS00470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HG576_RS00475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HG576_RS00505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG576_RS00515	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HG576_RS00520	COG0840	transmembrane signaling receptor activity
HG576_RS00525	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HG576_RS00540	COG1216	Glycosyl transferase, family 2
HG576_RS00550	COG0737	Belongs to the 5'-nucleotidase family
HG576_RS00560	COG0626	cystathionine gamma-synthase activity
HG576_RS00565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HG576_RS00585	COG1420	regulation of RNA biosynthetic process
HG576_RS00605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HG576_RS00610	COG0551	DNA topoisomerase type I activity
HG576_RS00610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HG576_RS00615	COG0731	radical SAM domain protein
HG576_RS00630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HG576_RS00630	COG0574	Belongs to the PEP-utilizing enzyme family
HG576_RS00645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HG576_RS00655	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HG576_RS00675	COG1760	l-serine dehydratase
HG576_RS00680	COG0814	amino acid
HG576_RS00685	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HG576_RS00690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG576_RS00700	COG1139	Iron-sulfur cluster binding protein
HG576_RS00705	COG0247	lactate metabolic process
HG576_RS00710	COG1620	l-lactate permease
HG576_RS00715	COG1620	l-lactate permease
HG576_RS00720	COG1194	a g-specific adenine glycosylase
HG576_RS00725	COG0471	metal ion transport
HG576_RS00730	COG3278	Belongs to the heme-copper respiratory oxidase family
HG576_RS00810	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG576_RS00815	COG0217	transcriptional regulatory protein
HG576_RS00820	COG0113	porphobilinogen synthase activity
HG576_RS00825	COG0642	Histidine kinase
HG576_RS00830	COG0745	RESPONSE REGULATOR receiver
HG576_RS00845	COG0826	peptidase U32
HG576_RS00860	COG0303	'Molybdopterin
HG576_RS00875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HG576_RS00880	COG0191	fructose-bisphosphate aldolase activity
HG576_RS00885	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HG576_RS00890	COG2089	acid synthase
HG576_RS00895	COG1136	(ABC) transporter
HG576_RS00900	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HG576_RS00910	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HG576_RS00940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HG576_RS00945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HG576_RS00950	COG1053	succinate dehydrogenase
HG576_RS00965	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HG576_RS00970	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG576_RS00980	COG0105	UTP biosynthetic process
HG576_RS01000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HG576_RS01015	COG0489	protein tyrosine kinase activity
HG576_RS01030	COG0326	Molecular chaperone. Has ATPase activity
HG576_RS01035	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG576_RS01050	COG0471	metal ion transport
HG576_RS01055	COG0575	Belongs to the CDS family
HG576_RS01075	COG1881	PFAM PEBP family protein
HG576_RS01100	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HG576_RS01105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG576_RS01105	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG576_RS01110	COG0730	response to heat
HG576_RS01120	COG0659	secondary active sulfate transmembrane transporter activity
HG576_RS01150	COG0754	glutathionylspermidine amidase activity
HG576_RS01160	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG576_RS01180	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HG576_RS01200	COG0783	Belongs to the Dps family
HG576_RS01205	COG0642	Histidine kinase
HG576_RS01210	COG3951	Flagellar rod assembly protein muramidase FlgJ
HG576_RS01235	COG4172	Belongs to the ABC transporter superfamily
HG576_RS01240	COG4239	(ABC) transporter, permease
HG576_RS01275	COG0750	zinc metalloprotease
HG576_RS01305	COG0542	response to heat
HG576_RS01310	COG0785	Cytochrome C biogenesis protein
HG576_RS01315	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HG576_RS01320	COG0402	S-adenosylhomocysteine deaminase activity
HG576_RS01355	COG0727	PFAM Uncharacterised protein family (UPF0153)
HG576_RS01365	COG0134	indole-3-glycerol-phosphate synthase activity
HG576_RS01375	COG0248	Ppx GppA phosphatase
HG576_RS01380	COG0859	PFAM glycosyl transferase family 9
HG576_RS01390	COG0343	queuine tRNA-ribosyltransferase activity
HG576_RS01410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HG576_RS01415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG576_RS01435	COG0019	diaminopimelate decarboxylase activity
HG576_RS01450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG576_RS01475	COG0747	negative chemotaxis
HG576_RS01480	COG0601	transmembrane transport
HG576_RS01485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HG576_RS01490	COG0444	Belongs to the ABC transporter superfamily
HG576_RS01495	COG4608	Belongs to the ABC transporter superfamily
HG576_RS01530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG576_RS01535	COG0726	polysaccharide deacetylase
HG576_RS01555	COG0523	cobalamin synthesis protein
HG576_RS01580	COG0748	coenzyme F420 binding
HG576_RS01615	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HG576_RS01620	COG3980	spore coat polysaccharide biosynthesis protein
HG576_RS01625	COG3980	spore coat polysaccharide biosynthesis protein
HG576_RS01630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HG576_RS01635	COG1663	tetraacyldisaccharide 4'-kinase activity
HG576_RS01655	COG2894	cell division
HG576_RS01665	COG0758	DNA mediated transformation
HG576_RS01665	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HG576_RS01670	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HG576_RS01675	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG576_RS01690	COG0564	pseudouridine synthase activity
HG576_RS01695	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HG576_RS01695	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HG576_RS01700	COG0504	CTP synthase activity
HG576_RS01710	COG1766	The M ring may be actively involved in energy transduction
HG576_RS01715	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG576_RS01725	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HG576_RS01745	COG4786	Flagellar basal body rod
HG576_RS01750	COG0477	Major facilitator Superfamily
HG576_RS01755	COG1674	ftsk spoiiie
HG576_RS01765	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HG576_RS01770	COG0196	riboflavin kinase activity
HG576_RS01775	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HG576_RS01795	COG1132	(ABC) transporter
HG576_RS01810	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HG576_RS01825	COG2608	mercury ion transmembrane transporter activity
HG576_RS01835	COG1183	phosphatidylcholine synthase activity
HG576_RS01845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG576_RS01850	COG2264	protein methyltransferase activity
HG576_RS01855	COG0745	RESPONSE REGULATOR receiver
HG576_RS01880	COG0357	Ribosomal RNA small subunit methyltransferase G
HG576_RS01890	COG0805	protein transport
HG576_RS01895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HG576_RS01930	COG0850	regulation of cytokinetic process
HG576_RS01945	COG0083	homoserine kinase activity
HG576_RS01960	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HG576_RS01975	COG1408	metallophosphoesterase
HG576_RS01980	COG0745	RESPONSE REGULATOR receiver
HG576_RS01990	COG2404	hydrolase activity, acting on ester bonds
HG576_RS01995	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG576_RS02015	COG0006	proline dipeptidase activity
HG576_RS02020	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HG576_RS02025	COG1419	protein localization to endoplasmic reticulum
HG576_RS02030	COG0455	bacterial-type flagellum organization
HG576_RS02045	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG576_RS02050	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG576_RS02050	COG1776	CheC inhibitor of MCP methylation
HG576_RS02065	COG0735	belongs to the Fur family
HG576_RS02070	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG576_RS02070	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HG576_RS02075	COG0789	Transcriptional regulator
HG576_RS02080	COG0484	heat shock protein binding
HG576_RS02095	COG0745	RESPONSE REGULATOR receiver
HG576_RS02110	COG0833	amino acid
HG576_RS02115	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HG576_RS02125	COG1028	Short-chain dehydrogenase reductase Sdr
HG576_RS02145	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HG576_RS02165	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HG576_RS02170	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HG576_RS02255	COG1217	gtp-binding protein TYPA
HG576_RS02320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HG576_RS02330	COG0824	Thioesterase
HG576_RS02335	COG0733	neurotransmitter:sodium symporter activity
HG576_RS02340	COG0733	neurotransmitter:sodium symporter activity
HG576_RS02350	COG0592	DNA-directed DNA polymerase activity
HG576_RS02355	COG0187	DNA topoisomerase II activity
HG576_RS02370	COG0741	lytic transglycosylase activity
HG576_RS02370	COG0739	heme binding
HG576_RS02370	COG1196	nuclear chromosome segregation
HG576_RS02385	COG0277	FAD linked oxidase domain protein
HG576_RS02410	COG3451	type IV secretory pathway VirB4
HG576_RS02490	COG2948	multi-organism process
HG576_RS02535	COG0174	glutamine synthetase
HG576_RS02545	COG4974	Belongs to the 'phage' integrase family
HG576_RS02550	COG3550	peptidyl-serine autophosphorylation
HG576_RS02620	COG1192	Involved in chromosome partitioning
HG576_RS02645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HG576_RS02675	COG0675	Transposase, IS605 OrfB family
HG576_RS02695	COG1607	acyl-coa hydrolase
HG576_RS02700	COG0300	oxidoreductase activity
HG576_RS02705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HG576_RS02710	COG1120	ATPase activity
HG576_RS02730	COG0728	peptidoglycan biosynthetic process
HG576_RS02740	COG0632	four-way junction helicase activity
HG576_RS02765	COG0753	catalase activity
HG576_RS02780	COG2824	Alkylphosphonate utilization operon protein PhnA
HG576_RS02785	COG2134	cdp-diacylglycerol pyrophosphatase
HG576_RS02790	COG1749	Flagellar hook protein flgE
HG576_RS02795	COG0375	protein maturation
HG576_RS02815	COG0756	dUTP diphosphatase activity
HG576_RS02830	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HG576_RS02840	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HG576_RS02845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG576_RS02865	COG0488	(ABC) transporter
HG576_RS02875	COG0671	phosphoesterase, PA-phosphatase related
HG576_RS02895	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HG576_RS02900	COG0351	phosphomethylpyrimidine kinase
HG576_RS02915	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HG576_RS02920	COG1086	Polysaccharide biosynthesis protein
HG576_RS02945	COG0776	regulation of translation
HG576_RS02965	COG0237	dephospho-CoA kinase activity
HG576_RS02975	COG0516	GMP reductase activity
HG576_RS02975	COG0517	IMP dehydrogenase activity
HG576_RS02985	COG0724	RNA recognition motif
HG576_RS02995	COG0492	ferredoxin-NADP+ reductase activity
HG576_RS03000	COG3118	belongs to the thioredoxin family
HG576_RS03005	COG0792	nuclease activity
HG576_RS03010	COG0460	homoserine dehydrogenase
HG576_RS03030	COG0517	IMP dehydrogenase activity
HG576_RS03030	COG1125	glycine betaine transport
HG576_RS03035	COG1732	Glycine betaine
HG576_RS03045	COG1360	Flagellar Motor Protein
HG576_RS03050	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HG576_RS03055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HG576_RS03080	COG1580	Controls the rotational direction of flagella during chemotaxis
HG576_RS03085	COG0736	holo-[acyl-carrier-protein] synthase activity
HG576_RS03105	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG576_RS03105	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG576_RS03125	COG0314	molybdopterin synthase activity
HG576_RS03130	COG0521	Mo-molybdopterin cofactor biosynthetic process
HG576_RS03155	COG0740	serine-type endopeptidase activity
HG576_RS03160	COG0242	peptide deformylase activity
HG576_RS03165	COG0606	chelatase, subunit chli
HG576_RS03170	COG2217	Heavy metal translocating P-type atpase
HG576_RS03185	COG3041	Addiction module toxin RelE StbE family
HG576_RS03245	COG1049	propionate catabolic process, 2-methylcitrate cycle
HG576_RS03255	COG0528	UMP kinase activity
HG576_RS03260	COG1758	RNA polymerase activity
HG576_RS03270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HG576_RS03280	COG0860	N-Acetylmuramoyl-L-alanine amidase
HG576_RS03290	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG576_RS03320	COG0552	protein localization to endoplasmic reticulum
HG576_RS03340	COG0534	Mate efflux family protein
HG576_RS03345	COG2056	Na+-H+ antiporter family
HG576_RS03375	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HG576_RS03395	COG2884	Cell division ATP-binding protein ftsE
HG576_RS03400	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HG576_RS03410	COG0564	pseudouridine synthase activity
HG576_RS03415	COG1162	GTPase activity
HG576_RS03425	COG0772	Belongs to the SEDS family
HG576_RS03435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG576_RS03445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HG576_RS03460	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HG576_RS03465	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HG576_RS03470	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HG576_RS03510	COG0037	tRNA processing
HG576_RS03515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG576_RS03530	COG0252	asparaginase activity
HG576_RS03535	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HG576_RS03555	COG1279	arginine transmembrane transporter activity
HG576_RS03560	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HG576_RS03570	COG1137	ATPase activity
HG576_RS03575	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HG576_RS03580	COG3177	Filamentation induced by cAMP protein fic
HG576_RS03595	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HG576_RS03615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HG576_RS03620	COG2204	response regulator
HG576_RS03630	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HG576_RS03635	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HG576_RS03645	COG0183	Belongs to the thiolase family
HG576_RS03650	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HG576_RS03655	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HG576_RS03660	COG2031	fatty acid transporter
HG576_RS03670	COG0145	ligase activity
HG576_RS03675	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HG576_RS03680	COG4647	ligase activity
HG576_RS03700	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HG576_RS03710	COG1338	Plays a role in the flagellum-specific transport system
HG576_RS03715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HG576_RS03740	COG0730	response to heat
HG576_RS03750	COG4974	Belongs to the 'phage' integrase family
HG576_RS03795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG576_RS03810	COG0571	ribonuclease III activity
HG576_RS03815	COG0328	RNA-DNA hybrid ribonuclease activity
HG576_RS03830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HG576_RS03840	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HG576_RS03845	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HG576_RS03850	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HG576_RS03855	COG1528	Iron-storage protein
HG576_RS03860	COG0560	Phosphoserine phosphatase
HG576_RS03875	COG1027	Aspartate ammonia-lyase
HG576_RS03895	COG0741	lytic transglycosylase activity
HG576_RS03900	COG0762	integral membrane protein
HG576_RS03945	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HG576_RS03950	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HG576_RS03955	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HG576_RS03960	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HG576_RS03965	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HG576_RS03970	COG2249	NAD(P)H dehydrogenase (quinone) activity
HG576_RS03985	COG2171	N-acyltransferase activity
HG576_RS03995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HG576_RS04010	COG1193	negative regulation of DNA recombination
HG576_RS04015	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HG576_RS04025	COG3306	glycosyltransferase involved in LPS biosynthesis
HG576_RS04030	COG0563	adenylate kinase activity
HG576_RS04040	COG0835	chemotaxis
HG576_RS04040	COG0784	Response regulator, receiver
HG576_RS04045	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HG576_RS04100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HG576_RS04110	COG0840	transmembrane signaling receptor activity
HG576_RS04115	COG0156	8-amino-7-oxononanoate synthase activity
HG576_RS04120	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HG576_RS04155	COG1013	pyruvate-flavodoxin oxidoreductase activity
HG576_RS04160	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HG576_RS04160	COG0674	pyruvate-flavodoxin oxidoreductase activity
HG576_RS04180	COG1918	ferrous iron import across plasma membrane
HG576_RS04185	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HG576_RS04190	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG576_RS04190	COG1776	CheC inhibitor of MCP methylation
HG576_RS04225	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HG576_RS04230	COG0681	Belongs to the peptidase S26 family
HG576_RS04235	COG1994	Peptidase M50
HG576_RS04240	COG0698	ribose 5-phosphate isomerase
HG576_RS04265	COG0012	GTP binding
HG576_RS04275	COG0628	permease
HG576_RS04305	COG1028	Short-chain dehydrogenase reductase Sdr
HG576_RS04310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HG576_RS04315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG576_RS04320	COG0825	malonyl-CoA metabolic process
HG576_RS04340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HG576_RS04345	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HG576_RS04355	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HG576_RS04375	COG1842	Phage shock protein A
HG576_RS04440	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HG576_RS04475	COG0409	Hydrogenase expression formation protein
HG576_RS04480	COG0409	Hydrogenase expression formation protein
HG576_RS04485	COG0298	carbon dioxide binding
HG576_RS04490	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HG576_RS04515	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HG576_RS04520	COG1749	Flagellar hook protein flgE
HG576_RS04520	COG1749	Flagellar hook protein flgE
HG576_RS04565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HG576_RS04570	COG0670	Belongs to the BI1 family
HG576_RS04575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG576_RS04590	COG1942	4-Oxalocrotonate Tautomerase
HG576_RS04605	COG0501	Belongs to the peptidase M48B family
HG576_RS04615	COG0142	geranyltranstransferase activity
HG576_RS04620	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HG576_RS04630	COG0720	synthase
HG576_RS04635	COG0602	queuosine metabolic process
HG576_RS04660	COG0765	amino acid transport
HG576_RS04665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HG576_RS04675	COG1115	amino acid carrier protein
HG576_RS04680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG576_RS04685	COG0251	oxidation-reduction process
HG576_RS04710	COG1757	Na H antiporter
HG576_RS04730	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HG576_RS04740	COG1058	Belongs to the CinA family
HG576_RS04740	COG1546	Belongs to the CinA family
HG576_RS04755	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HG576_RS04760	COG0564	pseudouridine synthase activity
HG576_RS04765	COG1519	Transferase
HG576_RS04775	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HG576_RS04780	COG0752	glycyl-tRNA synthetase alpha subunit
HG576_RS04785	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HG576_RS04795	COG1160	GTP binding
HG576_RS04805	COG3309	Virulence-associated protein D
HG576_RS04840	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HG576_RS04850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HG576_RS04860	COG0849	cell division
HG576_RS04865	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HG576_RS04880	COG0668	transmembrane transport
HG576_RS04920	COG1166	arginine decarboxylase activity
HG576_RS04945	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG576_RS04945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG576_RS04950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HG576_RS04955	COG0668	transmembrane transport
HG576_RS05005	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG576_RS05010	COG0537	adenosine 5'-monophosphoramidase activity
HG576_RS05020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG576_RS05020	COG0072	phenylalanine-tRNA ligase activity
HG576_RS05025	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HG576_RS05035	COG0539	negative regulation of cytoplasmic translation
HG576_RS05035	COG1185	polyribonucleotide nucleotidyltransferase activity
HG576_RS05045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HG576_RS05050	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HG576_RS05055	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HG576_RS05065	COG0784	Response regulator, receiver
HG576_RS05065	COG0835	chemotaxis
HG576_RS05070	COG2198	Histidine kinase
HG576_RS05070	COG0784	Response regulator, receiver
HG576_RS05070	COG0643	Histidine kinase
HG576_RS05075	COG0835	chemotaxis
HG576_RS05080	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HG576_RS05085	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HG576_RS05095	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HG576_RS05120	COG0501	Belongs to the peptidase M48B family
HG576_RS05125	COG2890	protein-(glutamine-N5) methyltransferase activity
HG576_RS05130	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HG576_RS05140	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HG576_RS05140	COG1333	cytochrome c biogenesis protein
HG576_RS05160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HG576_RS05175	COG0511	ligase activity, forming carbon-carbon bonds
HG576_RS05180	COG0439	Biotin carboxylase
HG576_RS05200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HG576_RS05210	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG576_RS05250	COG4221	oxidoreductase activity
HG576_RS05255	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG576_RS05260	COG0800	Aldolase
HG576_RS05265	COG0129	dihydroxy-acid dehydratase activity
HG576_RS05270	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HG576_RS05275	COG0363	glucosamine-6-phosphate deaminase activity
HG576_RS05280	COG0837	glucose binding
HG576_RS05285	COG1064	alcohol dehydrogenase
HG576_RS05315	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HG576_RS05325	COG0674	pyruvate-flavodoxin oxidoreductase activity
HG576_RS05330	COG1013	pyruvate-flavodoxin oxidoreductase activity
HG576_RS05335	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HG576_RS05370	COG0405	Gamma-glutamyltransferase
HG576_RS05400	COG1047	Peptidyl-prolyl cis-trans
HG576_RS05410	COG2885	chlorophyll binding
HG576_RS05415	COG0823	Involved in the tonB-independent uptake of proteins
HG576_RS05425	COG0848	biopolymer transport protein
HG576_RS05430	COG0811	peptide transport
HG576_RS05435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HG576_RS05445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HG576_RS05470	COG1475	DNA binding
HG576_RS05475	COG1192	Involved in chromosome partitioning
HG576_RS05485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HG576_RS05515	COG0335	large ribosomal subunit rRNA binding
HG576_RS05520	COG0336	Belongs to the RNA methyltransferase TrmD family
HG576_RS05535	COG0228	four-way junction DNA binding
HG576_RS05540	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HG576_RS05545	COG0525	valine-tRNA ligase activity
HG576_RS05570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HG576_RS05575	COG2184	nucleotidyltransferase activity
HG576_RS05585	COG0716	FMN binding
HG576_RS05600	COG0492	ferredoxin-NADP+ reductase activity
HG576_RS05620	COG1966	Carbon starvation protein
HG576_RS05630	COG0765	amino acid transport
HG576_RS05635	COG1126	abc transporter atp-binding protein
HG576_RS05650	COG0738	Major facilitator superfamily
HG576_RS05655	COG2252	PERMEase
HG576_RS05675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HG576_RS05685	COG2814	Major facilitator Superfamily
HG576_RS05690	COG0037	tRNA processing
HG576_RS05695	COG0475	glutathione-regulated potassium exporter activity
HG576_RS05695	COG0569	domain protein
HG576_RS05700	COG0534	Mate efflux family protein
HG576_RS05730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HG576_RS05740	COG0859	PFAM glycosyl transferase family 9
HG576_RS05750	COG0667	Aldo Keto reductase
HG576_RS05770	COG0085	RNA polymerase activity
HG576_RS05770	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HG576_RS05785	COG0081	regulation of translation
HG576_RS05795	COG0250	Participates in transcription elongation, termination and antitermination
HG576_RS05815	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HG576_RS05840	COG1132	(ABC) transporter
HG576_RS05860	COG1045	serine acetyltransferase
HG576_RS05890	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HG576_RS05900	COG0151	Belongs to the GarS family
HG576_RS05905	COG1131	(ABC) transporter
HG576_RS05910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HG576_RS05935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG576_RS05940	COG2863	cytochrome
HG576_RS05950	COG0527	aspartate kinase activity
HG576_RS05965	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HG576_RS05975	COG0697	spore germination
HG576_RS05990	COG0505	Belongs to the CarA family
HG576_RS06005	COG0424	maF-like protein
HG576_RS06010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HG576_RS06030	COG0629	single-stranded DNA binding
HG576_RS06040	COG1466	dna polymerase III delta subunit
HG576_RS06045	COG0557	exoribonuclease II activity
HG576_RS06060	COG4174	ABC transporter (Permease)
HG576_RS06070	COG0180	Tryptophanyl-tRNA synthetase
HG576_RS06080	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HG576_RS06100	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG576_RS06105	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG576_RS06115	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG576_RS06140	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HG576_RS06145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG576_RS06150	COG0839	Belongs to the complex I subunit 6 family
HG576_RS06160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HG576_RS06170	COG1007	ATP synthesis coupled electron transport
HG576_RS06190	COG0159	tryptophan synthase activity
HG576_RS06195	COG0133	tryptophan synthase activity
HG576_RS06200	COG0135	phosphoribosylanthranilate isomerase activity
HG576_RS06200	COG0134	indole-3-glycerol-phosphate synthase activity
HG576_RS06205	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HG576_RS06210	COG0512	Glutamine amidotransferase of anthranilate synthase
HG576_RS06215	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG576_RS06220	COG0859	PFAM glycosyl transferase family 9
HG576_RS06230	COG2353	YceI-like domain
HG576_RS06235	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HG576_RS06265	COG0202	RNA polymerase activity
HG576_RS06290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HG576_RS06295	COG0024	Methionine aminopeptidase
HG576_RS06300	COG0201	protein transport
HG576_RS06315	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HG576_RS06335	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG576_RS06355	COG0255	Belongs to the universal ribosomal protein uL29 family
HG576_RS06390	COG0088	Forms part of the polypeptide exit tunnel
HG576_RS06395	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HG576_RS06425	COG0114	fumarate hydratase activity
HG576_RS06445	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HG576_RS06450	COG1687	branched-chain amino acid
HG576_RS06455	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HG576_RS06460	COG0484	heat shock protein binding
HG576_RS06475	COG0482	sulfurtransferase activity
HG576_RS06495	COG0811	peptide transport
HG576_RS06500	COG0848	biopolymer transport protein
HG576_RS06505	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HG576_RS06515	COG0861	Integral membrane protein TerC family
HG576_RS06520	COG0598	Magnesium transport protein CorA
HG576_RS06525	COG0126	phosphoglycerate kinase activity
HG576_RS06530	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG576_RS06540	COG0204	Acyl-transferase
HG576_RS06550	COG0793	Belongs to the peptidase S41A family
HG576_RS06570	COG0157	Belongs to the NadC ModD family
HG576_RS06575	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HG576_RS06595	COG0109	protoheme IX farnesyltransferase activity
HG576_RS06605	COG0305	Participates in initiation and elongation during chromosome replication
HG576_RS06610	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HG576_RS06610	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HG576_RS06615	COG0642	Histidine kinase
HG576_RS06620	COG0745	RESPONSE REGULATOR receiver
HG576_RS06640	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HG576_RS06645	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HG576_RS06660	COG1077	Cell shape determining protein MreB Mrl
HG576_RS06665	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HG576_RS06675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HG576_RS06685	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HG576_RS06690	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HG576_RS06695	COG0287	Prephenate dehydrogenase
HG576_RS06705	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HG576_RS06720	COG1295	ribonuclease BN
HG576_RS06760	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HG576_RS06765	COG0799	negative regulation of ribosome biogenesis
HG576_RS06770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HG576_RS06790	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HG576_RS06795	COG1987	bacterial-type flagellum assembly
HG576_RS06800	COG1157	protein secretion by the type III secretion system
HG576_RS06805	COG4962	Type ii secretion system protein e
HG576_RS06815	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HG576_RS06840	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HG576_RS06845	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HG576_RS06845	COG0517	IMP dehydrogenase activity
HG576_RS06850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HG576_RS06865	COG0788	formyltetrahydrofolate deformylase activity
HG576_RS06870	COG0616	signal peptide processing
HG576_RS06905	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG576_RS06915	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HG576_RS06920	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HG576_RS06925	COG0811	peptide transport
HG576_RS06930	COG0848	biopolymer transport protein
HG576_RS06945	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HG576_RS06950	COG0706	membrane insertase activity
HG576_RS06960	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG576_RS06995	COG3118	belongs to the thioredoxin family
HG576_RS07000	COG1187	pseudouridine synthase activity
HG576_RS07005	COG0587	DNA-directed DNA polymerase activity
HG576_RS07030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HG576_RS07035	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HG576_RS07045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HG576_RS07055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG576_RS07055	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG576_RS07075	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HG576_RS07080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HG576_RS07085	COG0163	prenyltransferase activity
HG576_RS07095	COG0210	DNA helicase
HG576_RS07125	COG2226	methyltransferase
HG576_RS07130	COG1981	membrane
HG576_RS07135	COG1739	Uncharacterized protein family UPF0029
HG576_RS07150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG576_RS07160	COG1253	flavin adenine dinucleotide binding
HG576_RS07165	COG0306	phosphate transporter
HG576_RS07170	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HG576_RS07180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HG576_RS07185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HG576_RS07235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HG576_RS07245	COG0786	glutamate:sodium symporter activity
HG576_RS07255	COG0348	domain, Protein
HG576_RS07260	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HG576_RS07280	COG1921	L-seryl-tRNASec selenium transferase activity
HG576_RS07285	COG0195	Participates in both transcription termination and antitermination
HG576_RS07320	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HG576_RS07335	COG0708	Exodeoxyribonuclease III
HG576_RS07350	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HG576_RS07365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HG576_RS07370	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HG576_RS07375	COG0732	type I restriction modification DNA specificity domain
HG576_RS07390	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HG576_RS07400	COG4772	TonB-dependent receptor
HG576_RS07405	COG0010	Belongs to the arginase family
HG576_RS07415	COG0686	Belongs to the AlaDH PNT family
HG576_RS07435	COG0497	DNA recombination
HG576_RS07450	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG576_RS07460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HG576_RS07495	COG1074	ATP-dependent DNA helicase activity
HG576_RS07505	COG1862	Preprotein translocase
HG576_RS07510	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HG576_RS07515	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HG576_RS07535	COG0285	dihydrofolate synthase activity
HG576_RS07545	COG0739	heme binding
HG576_RS07555	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HG576_RS07560	COG0723	plastoquinol--plastocyanin reductase activity
HG576_RS07580	COG1106	Psort location Cytoplasmic, score
HG576_RS07585	COG0768	penicillin binding
HG576_RS07600	COG1558	bacterial-type flagellum-dependent cell motility
HG576_RS07605	COG1815	bacterial-type flagellum-dependent cell motility
HG576_RS07610	COG0772	Belongs to the SEDS family
HG576_RS07625	COG0450	alkyl hydroperoxide reductase
HG576_RS07635	COG0768	penicillin binding
HG576_RS07660	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HG576_RS07665	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HG576_RS07670	COG1388	LysM domain
HG576_RS07670	COG0741	lytic transglycosylase activity
HG576_RS07675	COG0084	hydrolase, TatD family'
HG576_RS07680	COG0307	riboflavin synthase, alpha
HG576_RS07690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HG576_RS07695	COG2011	ABC-type metal ion transport system permease component
HG576_RS07705	COG0671	phosphoesterase, PA-phosphatase related
HG576_RS07710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HG576_RS07730	COG4786	Flagellar basal body rod