locus-tag	class	description
HG581_RS00020	COG0288	reversible hydration of carbon dioxide
HG581_RS00065	COG0459	protein refolding
HG581_RS00075	COG0358	DNA primase activity
HG581_RS00080	COG0482	sulfurtransferase activity
HG581_RS00115	COG0784	Response regulator, receiver
HG581_RS00115	COG0835	chemotaxis
HG581_RS00125	COG0671	phosphoesterase, PA-phosphatase related
HG581_RS00130	COG2194	sulfuric ester hydrolase activity
HG581_RS00140	COG0372	Belongs to the citrate synthase family
HG581_RS00145	COG0538	isocitrate dehydrogenase activity
HG581_RS00165	COG0589	response to stress
HG581_RS00170	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HG581_RS00175	COG0542	response to heat
HG581_RS00180	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HG581_RS00225	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HG581_RS00245	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HG581_RS00275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG581_RS00280	COG0506	proline dehydrogenase activity
HG581_RS00280	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HG581_RS00280	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HG581_RS00370	COG0804	urea catabolic process
HG581_RS00375	COG0832	Belongs to the urease beta subunit family
HG581_RS00375	COG0831	urea catabolic process
HG581_RS00395	COG0268	Binds directly to 16S ribosomal RNA
HG581_RS00420	COG0840	transmembrane signaling receptor activity
HG581_RS00450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG581_RS00455	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HG581_RS00460	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HG581_RS00495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG581_RS00505	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HG581_RS00515	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HG581_RS00525	COG1216	Glycosyl transferase, family 2
HG581_RS00535	COG0737	Belongs to the 5'-nucleotidase family
HG581_RS00545	COG0626	cystathionine gamma-synthase activity
HG581_RS00550	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HG581_RS00570	COG1420	regulation of RNA biosynthetic process
HG581_RS00590	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HG581_RS00595	COG0551	DNA topoisomerase type I activity
HG581_RS00595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HG581_RS00600	COG0731	radical SAM domain protein
HG581_RS00610	COG0574	Belongs to the PEP-utilizing enzyme family
HG581_RS00610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HG581_RS00620	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HG581_RS00650	COG1760	l-serine dehydratase
HG581_RS00655	COG0814	amino acid
HG581_RS00660	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HG581_RS00665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG581_RS00675	COG1139	Iron-sulfur cluster binding protein
HG581_RS00680	COG0247	lactate metabolic process
HG581_RS00685	COG1620	l-lactate permease
HG581_RS00690	COG1620	l-lactate permease
HG581_RS00695	COG1194	a g-specific adenine glycosylase
HG581_RS00700	COG0471	metal ion transport
HG581_RS00705	COG3278	Belongs to the heme-copper respiratory oxidase family
HG581_RS00745	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HG581_RS00755	COG0148	phosphopyruvate hydratase activity
HG581_RS00785	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG581_RS00795	COG0113	porphobilinogen synthase activity
HG581_RS00800	COG0642	Histidine kinase
HG581_RS00805	COG0745	RESPONSE REGULATOR receiver
HG581_RS00820	COG0826	peptidase U32
HG581_RS00835	COG0303	'Molybdopterin
HG581_RS00850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HG581_RS00855	COG0191	fructose-bisphosphate aldolase activity
HG581_RS00870	COG0489	protein tyrosine kinase activity
HG581_RS00910	COG0105	UTP biosynthetic process
HG581_RS00915	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HG581_RS00925	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HG581_RS00940	COG1053	succinate dehydrogenase
HG581_RS00945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HG581_RS00950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HG581_RS00980	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HG581_RS00990	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HG581_RS00995	COG1136	(ABC) transporter
HG581_RS01000	COG2089	acid synthase
HG581_RS01015	COG0326	Molecular chaperone. Has ATPase activity
HG581_RS01020	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG581_RS01030	COG0445	tRNA wobble uridine modification
HG581_RS01035	COG0471	metal ion transport
HG581_RS01040	COG0575	Belongs to the CDS family
HG581_RS01050	COG1881	PFAM PEBP family protein
HG581_RS01075	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HG581_RS01080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG581_RS01080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG581_RS01085	COG0730	response to heat
HG581_RS01095	COG0659	secondary active sulfate transmembrane transporter activity
HG581_RS01125	COG0754	glutathionylspermidine amidase activity
HG581_RS01135	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG581_RS01145	COG0181	hydroxymethylbilane synthase activity
HG581_RS01175	COG0783	Belongs to the Dps family
HG581_RS01180	COG0642	Histidine kinase
HG581_RS01185	COG3951	Flagellar rod assembly protein muramidase FlgJ
HG581_RS01210	COG4172	Belongs to the ABC transporter superfamily
HG581_RS01215	COG4239	(ABC) transporter, permease
HG581_RS01250	COG0750	zinc metalloprotease
HG581_RS01255	COG1570	exodeoxyribonuclease VII activity
HG581_RS01280	COG0542	response to heat
HG581_RS01285	COG0785	Cytochrome C biogenesis protein
HG581_RS01290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HG581_RS01295	COG0402	S-adenosylhomocysteine deaminase activity
HG581_RS01330	COG0727	PFAM Uncharacterised protein family (UPF0153)
HG581_RS01340	COG0134	indole-3-glycerol-phosphate synthase activity
HG581_RS01350	COG0248	Ppx GppA phosphatase
HG581_RS01355	COG0859	PFAM glycosyl transferase family 9
HG581_RS01375	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HG581_RS01385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HG581_RS01390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG581_RS01410	COG0019	diaminopimelate decarboxylase activity
HG581_RS01425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG581_RS01450	COG0747	negative chemotaxis
HG581_RS01455	COG0601	transmembrane transport
HG581_RS01460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HG581_RS01465	COG0444	Belongs to the ABC transporter superfamily
HG581_RS01470	COG4608	Belongs to the ABC transporter superfamily
HG581_RS01505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG581_RS01510	COG0726	polysaccharide deacetylase
HG581_RS01520	COG0523	cobalamin synthesis protein
HG581_RS01530	COG0748	coenzyme F420 binding
HG581_RS01545	COG0194	GDP metabolic process
HG581_RS01565	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HG581_RS01570	COG3980	spore coat polysaccharide biosynthesis protein
HG581_RS01575	COG3980	spore coat polysaccharide biosynthesis protein
HG581_RS01580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HG581_RS01585	COG1663	tetraacyldisaccharide 4'-kinase activity
HG581_RS01605	COG2894	cell division
HG581_RS01615	COG0758	DNA mediated transformation
HG581_RS01615	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HG581_RS01620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HG581_RS01625	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG581_RS01640	COG0564	pseudouridine synthase activity
HG581_RS01645	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HG581_RS01645	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HG581_RS01650	COG0504	CTP synthase activity
HG581_RS01660	COG1766	The M ring may be actively involved in energy transduction
HG581_RS01665	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG581_RS01675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HG581_RS01695	COG4786	Flagellar basal body rod
HG581_RS01700	COG0477	Major facilitator Superfamily
HG581_RS01705	COG1674	ftsk spoiiie
HG581_RS01715	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HG581_RS01720	COG0196	riboflavin kinase activity
HG581_RS01725	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HG581_RS01745	COG1132	(ABC) transporter
HG581_RS01760	COG1106	Psort location Cytoplasmic, score
HG581_RS01770	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HG581_RS01785	COG2608	mercury ion transmembrane transporter activity
HG581_RS01790	COG2217	Heavy metal translocating P-type atpase
HG581_RS01795	COG1183	phosphatidylcholine synthase activity
HG581_RS01805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG581_RS01810	COG2264	protein methyltransferase activity
HG581_RS01815	COG0745	RESPONSE REGULATOR receiver
HG581_RS01840	COG0357	Ribosomal RNA small subunit methyltransferase G
HG581_RS01850	COG0805	protein transport
HG581_RS01855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HG581_RS01890	COG0850	regulation of cytokinetic process
HG581_RS01905	COG0083	homoserine kinase activity
HG581_RS01925	COG0779	Required for maturation of 30S ribosomal subunits
HG581_RS01935	COG1408	metallophosphoesterase
HG581_RS01940	COG0745	RESPONSE REGULATOR receiver
HG581_RS01950	COG2404	hydrolase activity, acting on ester bonds
HG581_RS01955	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG581_RS01960	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HG581_RS01975	COG0006	proline dipeptidase activity
HG581_RS01980	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HG581_RS01985	COG1419	protein localization to endoplasmic reticulum
HG581_RS01990	COG0455	bacterial-type flagellum organization
HG581_RS02005	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG581_RS02010	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG581_RS02010	COG1776	CheC inhibitor of MCP methylation
HG581_RS02025	COG0735	belongs to the Fur family
HG581_RS02030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG581_RS02030	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HG581_RS02035	COG0789	Transcriptional regulator
HG581_RS02040	COG0484	heat shock protein binding
HG581_RS02055	COG0745	RESPONSE REGULATOR receiver
HG581_RS02060	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HG581_RS02060	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HG581_RS02070	COG0833	amino acid
HG581_RS02075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HG581_RS02085	COG1028	Short-chain dehydrogenase reductase Sdr
HG581_RS02090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG581_RS02100	COG0167	dihydroorotate dehydrogenase activity
HG581_RS02105	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HG581_RS02210	COG1217	gtp-binding protein TYPA
HG581_RS02270	COG3451	type IV secretory pathway VirB4
HG581_RS02305	COG4962	Type ii secretion system protein e
HG581_RS02325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HG581_RS02350	COG1192	Involved in chromosome partitioning
HG581_RS02400	COG3550	peptidyl-serine autophosphorylation
HG581_RS02405	COG4974	Belongs to the 'phage' integrase family
HG581_RS02475	COG0824	Thioesterase
HG581_RS02480	COG0733	neurotransmitter:sodium symporter activity
HG581_RS02485	COG0733	neurotransmitter:sodium symporter activity
HG581_RS02495	COG0592	DNA-directed DNA polymerase activity
HG581_RS02500	COG0187	DNA topoisomerase II activity
HG581_RS02515	COG0741	lytic transglycosylase activity
HG581_RS02515	COG1196	nuclear chromosome segregation
HG581_RS02515	COG0739	heme binding
HG581_RS02530	COG0277	FAD linked oxidase domain protein
HG581_RS02585	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HG581_RS02590	COG0359	binds to the 23S rRNA
HG581_RS02600	COG0174	glutamine synthetase
HG581_RS02615	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HG581_RS02625	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HG581_RS02630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HG581_RS02655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG581_RS02665	COG1028	Short-chain dehydrogenase reductase Sdr
HG581_RS02690	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HG581_RS02695	COG0628	permease
HG581_RS02705	COG0012	GTP binding
HG581_RS02730	COG0698	ribose 5-phosphate isomerase
HG581_RS02735	COG1994	Peptidase M50
HG581_RS02740	COG0681	Belongs to the peptidase S26 family
HG581_RS02780	COG1776	CheC inhibitor of MCP methylation
HG581_RS02780	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG581_RS02785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HG581_RS02790	COG1918	ferrous iron import across plasma membrane
HG581_RS02810	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HG581_RS02810	COG0674	pyruvate-flavodoxin oxidoreductase activity
HG581_RS02815	COG1013	pyruvate-flavodoxin oxidoreductase activity
HG581_RS02855	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HG581_RS02860	COG0156	8-amino-7-oxononanoate synthase activity
HG581_RS02865	COG0840	transmembrane signaling receptor activity
HG581_RS02875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HG581_RS02915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG581_RS02925	COG1131	(ABC) transporter
HG581_RS02940	COG0835	chemotaxis
HG581_RS02940	COG0784	Response regulator, receiver
HG581_RS02950	COG0563	adenylate kinase activity
HG581_RS02975	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HG581_RS02980	COG1193	negative regulation of DNA recombination
HG581_RS02995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HG581_RS03005	COG2171	N-acyltransferase activity
HG581_RS03020	COG2249	NAD(P)H dehydrogenase (quinone) activity
HG581_RS03025	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HG581_RS03030	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HG581_RS03035	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HG581_RS03040	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HG581_RS03045	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HG581_RS03075	COG2084	Dehydrogenase
HG581_RS03080	COG0778	Nitroreductase
HG581_RS03090	COG0762	integral membrane protein
HG581_RS03095	COG0741	lytic transglycosylase activity
HG581_RS03115	COG1027	Aspartate ammonia-lyase
HG581_RS03130	COG0560	Phosphoserine phosphatase
HG581_RS03135	COG1528	Iron-storage protein
HG581_RS03140	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HG581_RS03145	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HG581_RS03150	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HG581_RS03160	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HG581_RS03175	COG0328	RNA-DNA hybrid ribonuclease activity
HG581_RS03180	COG0571	ribonuclease III activity
HG581_RS03195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG581_RS03230	COG4974	Belongs to the 'phage' integrase family
HG581_RS03240	COG0730	response to heat
HG581_RS03250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG581_RS03275	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HG581_RS03280	COG1338	Plays a role in the flagellum-specific transport system
HG581_RS03290	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HG581_RS03315	COG0183	Belongs to the thiolase family
HG581_RS03320	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HG581_RS03325	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HG581_RS03330	COG2031	fatty acid transporter
HG581_RS03340	COG0145	ligase activity
HG581_RS03345	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HG581_RS03350	COG4647	ligase activity
HG581_RS03365	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HG581_RS03370	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HG581_RS03380	COG2204	response regulator
HG581_RS03395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HG581_RS03415	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HG581_RS03435	COG3177	Filamentation induced by cAMP protein fic
HG581_RS03440	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HG581_RS03445	COG1137	ATPase activity
HG581_RS03455	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HG581_RS03460	COG1279	arginine transmembrane transporter activity
HG581_RS03480	COG0252	asparaginase activity
HG581_RS03485	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HG581_RS03500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG581_RS03505	COG0037	tRNA processing
HG581_RS03535	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HG581_RS03540	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HG581_RS03545	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HG581_RS03550	COG1181	Belongs to the D-alanine--D-alanine ligase family
HG581_RS03560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HG581_RS03570	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG581_RS03580	COG0772	Belongs to the SEDS family
HG581_RS03590	COG0564	pseudouridine synthase activity
HG581_RS03605	COG2884	Cell division ATP-binding protein ftsE
HG581_RS03625	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HG581_RS03655	COG2056	Na+-H+ antiporter family
HG581_RS03660	COG0534	Mate efflux family protein
HG581_RS03680	COG0552	protein localization to endoplasmic reticulum
HG581_RS03700	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG581_RS03710	COG0860	N-Acetylmuramoyl-L-alanine amidase
HG581_RS03720	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HG581_RS03730	COG1758	RNA polymerase activity
HG581_RS03735	COG0528	UMP kinase activity
HG581_RS03745	COG1049	propionate catabolic process, 2-methylcitrate cycle
HG581_RS03795	COG0732	type I restriction modification DNA specificity domain
HG581_RS03800	COG2217	Heavy metal translocating P-type atpase
HG581_RS03805	COG0606	chelatase, subunit chli
HG581_RS03815	COG0740	serine-type endopeptidase activity
HG581_RS03840	COG0521	Mo-molybdopterin cofactor biosynthetic process
HG581_RS03845	COG0314	molybdopterin synthase activity
HG581_RS03865	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG581_RS03865	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG581_RS03885	COG0736	holo-[acyl-carrier-protein] synthase activity
HG581_RS03890	COG1580	Controls the rotational direction of flagella during chemotaxis
HG581_RS03910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG581_RS03915	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HG581_RS03920	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HG581_RS03925	COG1360	Flagellar Motor Protein
HG581_RS03935	COG1732	Glycine betaine
HG581_RS03940	COG0517	IMP dehydrogenase activity
HG581_RS03940	COG1125	glycine betaine transport
HG581_RS03960	COG0460	homoserine dehydrogenase
HG581_RS03965	COG0792	nuclease activity
HG581_RS03970	COG3118	belongs to the thioredoxin family
HG581_RS03975	COG0492	ferredoxin-NADP+ reductase activity
HG581_RS03985	COG0724	RNA recognition motif
HG581_RS03995	COG0517	IMP dehydrogenase activity
HG581_RS03995	COG0516	GMP reductase activity
HG581_RS04000	COG0154	amidase activity
HG581_RS04005	COG0237	dephospho-CoA kinase activity
HG581_RS04010	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HG581_RS04025	COG0776	regulation of translation
HG581_RS04050	COG1086	Polysaccharide biosynthesis protein
HG581_RS04055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HG581_RS04065	COG0352	thiamine-phosphate diphosphorylase activity
HG581_RS04070	COG0351	phosphomethylpyrimidine kinase
HG581_RS04075	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HG581_RS04080	COG0671	phosphoesterase, PA-phosphatase related
HG581_RS04090	COG0488	(ABC) transporter
HG581_RS04095	COG0516	GMP reductase activity
HG581_RS04100	COG1696	Membrane protein involved in D-alanine export
HG581_RS04120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG581_RS04125	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HG581_RS04150	COG0756	dUTP diphosphatase activity
HG581_RS04155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HG581_RS04170	COG0375	protein maturation
HG581_RS04175	COG1749	Flagellar hook protein flgE
HG581_RS04185	COG2824	Alkylphosphonate utilization operon protein PhnA
HG581_RS04200	COG0753	catalase activity
HG581_RS04210	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HG581_RS04225	COG0632	four-way junction helicase activity
HG581_RS04240	COG0728	peptidoglycan biosynthetic process
HG581_RS04255	COG1120	ATPase activity
HG581_RS04260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HG581_RS04265	COG0300	oxidoreductase activity
HG581_RS04270	COG1607	acyl-coa hydrolase
HG581_RS04300	COG0409	Hydrogenase expression formation protein
HG581_RS04310	COG0298	carbon dioxide binding
HG581_RS04315	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HG581_RS04335	COG0280	phosphate acetyltransferase
HG581_RS04345	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HG581_RS04350	COG1749	Flagellar hook protein flgE
HG581_RS04350	COG1749	Flagellar hook protein flgE
HG581_RS04395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HG581_RS04400	COG0670	Belongs to the BI1 family
HG581_RS04405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG581_RS04420	COG1942	4-Oxalocrotonate Tautomerase
HG581_RS04435	COG0501	Belongs to the peptidase M48B family
HG581_RS04445	COG0142	geranyltranstransferase activity
HG581_RS04460	COG0720	synthase
HG581_RS04465	COG0602	queuosine metabolic process
HG581_RS04490	COG0765	amino acid transport
HG581_RS04495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HG581_RS04505	COG1115	amino acid carrier protein
HG581_RS04510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG581_RS04515	COG0251	oxidation-reduction process
HG581_RS04540	COG1757	Na H antiporter
HG581_RS04560	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HG581_RS04570	COG1058	Belongs to the CinA family
HG581_RS04570	COG1546	Belongs to the CinA family
HG581_RS04585	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HG581_RS04590	COG0564	pseudouridine synthase activity
HG581_RS04595	COG1519	Transferase
HG581_RS04605	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HG581_RS04615	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HG581_RS04625	COG1160	GTP binding
HG581_RS04655	COG0751	glycine-tRNA ligase activity
HG581_RS04665	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HG581_RS04675	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HG581_RS04685	COG0849	cell division
HG581_RS04690	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HG581_RS04705	COG0668	transmembrane transport
HG581_RS04755	COG1598	PFAM Uncharacterised protein family UPF0150
HG581_RS04765	COG1166	arginine decarboxylase activity
HG581_RS04790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG581_RS04790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG581_RS04795	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HG581_RS04800	COG0668	transmembrane transport
HG581_RS04850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG581_RS04855	COG0537	adenosine 5'-monophosphoramidase activity
HG581_RS04865	COG0072	phenylalanine-tRNA ligase activity
HG581_RS04865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG581_RS04870	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HG581_RS04880	COG1185	polyribonucleotide nucleotidyltransferase activity
HG581_RS04880	COG0539	negative regulation of cytoplasmic translation
HG581_RS04890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HG581_RS04895	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HG581_RS04900	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HG581_RS04910	COG0784	Response regulator, receiver
HG581_RS04910	COG0835	chemotaxis
HG581_RS04915	COG0784	Response regulator, receiver
HG581_RS04915	COG0643	Histidine kinase
HG581_RS04915	COG2198	Histidine kinase
HG581_RS04920	COG0835	chemotaxis
HG581_RS04925	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HG581_RS04930	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HG581_RS04940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HG581_RS04965	COG0501	Belongs to the peptidase M48B family
HG581_RS04970	COG2890	protein-(glutamine-N5) methyltransferase activity
HG581_RS04975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HG581_RS04985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HG581_RS04985	COG1333	cytochrome c biogenesis protein
HG581_RS05005	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HG581_RS05030	COG0511	ligase activity, forming carbon-carbon bonds
HG581_RS05035	COG0439	Biotin carboxylase
HG581_RS05065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HG581_RS05075	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG581_RS05115	COG4221	oxidoreductase activity
HG581_RS05120	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG581_RS05125	COG0800	Aldolase
HG581_RS05130	COG0129	dihydroxy-acid dehydratase activity
HG581_RS05135	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HG581_RS05140	COG0363	glucosamine-6-phosphate deaminase activity
HG581_RS05150	COG1064	alcohol dehydrogenase
HG581_RS05170	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HG581_RS05180	COG0674	pyruvate-flavodoxin oxidoreductase activity
HG581_RS05185	COG1013	pyruvate-flavodoxin oxidoreductase activity
HG581_RS05190	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HG581_RS05200	COG0556	nucleotide-excision repair
HG581_RS05225	COG0405	Gamma-glutamyltransferase
HG581_RS05255	COG1047	Peptidyl-prolyl cis-trans
HG581_RS05265	COG2885	chlorophyll binding
HG581_RS05270	COG0823	Involved in the tonB-independent uptake of proteins
HG581_RS05280	COG0848	biopolymer transport protein
HG581_RS05285	COG0811	peptide transport
HG581_RS05300	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HG581_RS05315	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HG581_RS05325	COG1475	DNA binding
HG581_RS05330	COG1192	Involved in chromosome partitioning
HG581_RS05370	COG0336	Belongs to the RNA methyltransferase TrmD family
HG581_RS05385	COG0228	four-way junction DNA binding
HG581_RS05390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HG581_RS05395	COG0525	valine-tRNA ligase activity
HG581_RS05420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HG581_RS05435	COG0716	FMN binding
HG581_RS05450	COG0492	ferredoxin-NADP+ reductase activity
HG581_RS05470	COG1966	Carbon starvation protein
HG581_RS05480	COG0765	amino acid transport
HG581_RS05485	COG1126	abc transporter atp-binding protein
HG581_RS05500	COG0738	Major facilitator superfamily
HG581_RS05505	COG2252	PERMEase
HG581_RS05520	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HG581_RS05525	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HG581_RS05535	COG2814	Major facilitator Superfamily
HG581_RS05540	COG0037	tRNA processing
HG581_RS05545	COG0569	domain protein
HG581_RS05545	COG0475	glutathione-regulated potassium exporter activity
HG581_RS05555	COG2814	Major facilitator Superfamily
HG581_RS05575	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HG581_RS05580	COG0124	histidyl-tRNA synthetase
HG581_RS05585	COG0859	PFAM glycosyl transferase family 9
HG581_RS05595	COG0667	Aldo Keto reductase
HG581_RS05600	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG581_RS05640	COG0250	Participates in transcription elongation, termination and antitermination
HG581_RS05660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HG581_RS05685	COG1132	(ABC) transporter
HG581_RS05705	COG1045	serine acetyltransferase
HG581_RS05735	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HG581_RS05745	COG0151	Belongs to the GarS family
HG581_RS05760	COG1131	(ABC) transporter
HG581_RS05765	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HG581_RS05785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HG581_RS05790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG581_RS05795	COG2863	cytochrome
HG581_RS05805	COG0527	aspartate kinase activity
HG581_RS05820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HG581_RS05860	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HG581_RS05865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG581_RS05870	COG2863	cytochrome
HG581_RS05880	COG0527	aspartate kinase activity
HG581_RS05895	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HG581_RS05905	COG0697	spore germination
HG581_RS05920	COG0505	Belongs to the CarA family
HG581_RS05940	COG0424	maF-like protein
HG581_RS05945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HG581_RS05965	COG0629	single-stranded DNA binding
HG581_RS05975	COG1466	dna polymerase III delta subunit
HG581_RS05980	COG0557	exoribonuclease II activity
HG581_RS05985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HG581_RS05995	COG4174	ABC transporter (Permease)
HG581_RS06000	COG4166	transmembrane transport
HG581_RS06005	COG0180	Tryptophanyl-tRNA synthetase
HG581_RS06015	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HG581_RS06035	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG581_RS06040	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG581_RS06075	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HG581_RS06085	COG0839	Belongs to the complex I subunit 6 family
HG581_RS06095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HG581_RS06105	COG1007	ATP synthesis coupled electron transport
HG581_RS06140	COG0159	tryptophan synthase activity
HG581_RS06145	COG0133	tryptophan synthase activity
HG581_RS06150	COG0135	phosphoribosylanthranilate isomerase activity
HG581_RS06150	COG0134	indole-3-glycerol-phosphate synthase activity
HG581_RS06155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HG581_RS06160	COG0512	Glutamine amidotransferase of anthranilate synthase
HG581_RS06165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG581_RS06180	COG0859	PFAM glycosyl transferase family 9
HG581_RS06190	COG2353	YceI-like domain
HG581_RS06195	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HG581_RS06225	COG0202	RNA polymerase activity
HG581_RS06250	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HG581_RS06255	COG0024	Methionine aminopeptidase
HG581_RS06260	COG0201	protein transport
HG581_RS06275	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HG581_RS06280	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HG581_RS06295	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG581_RS06315	COG0255	Belongs to the universal ribosomal protein uL29 family
HG581_RS06350	COG0088	Forms part of the polypeptide exit tunnel
HG581_RS06355	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HG581_RS06385	COG0114	fumarate hydratase activity
HG581_RS06400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG581_RS06410	COG1687	branched-chain amino acid
HG581_RS06415	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HG581_RS06420	COG0484	heat shock protein binding
HG581_RS06430	COG0482	sulfurtransferase activity
HG581_RS06440	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HG581_RS06450	COG0811	peptide transport
HG581_RS06455	COG0848	biopolymer transport protein
HG581_RS06460	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HG581_RS06470	COG0861	Integral membrane protein TerC family
HG581_RS06475	COG0598	Magnesium transport protein CorA
HG581_RS06480	COG0126	phosphoglycerate kinase activity
HG581_RS06485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG581_RS06495	COG0204	Acyl-transferase
HG581_RS06505	COG0793	Belongs to the peptidase S41A family
HG581_RS06525	COG0157	Belongs to the NadC ModD family
HG581_RS06530	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HG581_RS06550	COG0109	protoheme IX farnesyltransferase activity
HG581_RS06560	COG0305	Participates in initiation and elongation during chromosome replication
HG581_RS06565	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HG581_RS06565	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HG581_RS06570	COG0642	Histidine kinase
HG581_RS06575	COG0745	RESPONSE REGULATOR receiver
HG581_RS06585	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HG581_RS06600	COG1077	Cell shape determining protein MreB Mrl
HG581_RS06605	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HG581_RS06610	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG581_RS06615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HG581_RS06625	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HG581_RS06630	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HG581_RS06635	COG0287	Prephenate dehydrogenase
HG581_RS06645	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HG581_RS06670	COG1295	ribonuclease BN
HG581_RS06710	COG0799	negative regulation of ribosome biogenesis
HG581_RS06715	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HG581_RS06735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HG581_RS06740	COG1987	bacterial-type flagellum assembly
HG581_RS06745	COG1157	protein secretion by the type III secretion system
HG581_RS06750	COG4962	Type ii secretion system protein e
HG581_RS06760	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HG581_RS06785	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HG581_RS06785	COG0517	IMP dehydrogenase activity
HG581_RS06790	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HG581_RS06810	COG0788	formyltetrahydrofolate deformylase activity
HG581_RS06855	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG581_RS06865	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HG581_RS06875	COG0811	peptide transport
HG581_RS06880	COG0848	biopolymer transport protein
HG581_RS06895	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HG581_RS06900	COG0706	membrane insertase activity
HG581_RS06910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG581_RS07010	COG3041	Addiction module toxin RelE StbE family
HG581_RS07045	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HG581_RS07085	COG3451	type IV secretory pathway VirB4
HG581_RS07115	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HG581_RS07120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HG581_RS07135	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HG581_RS07150	COG0708	Exodeoxyribonuclease III
HG581_RS07165	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HG581_RS07210	COG0195	Participates in both transcription termination and antitermination
HG581_RS07235	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HG581_RS07240	COG0348	domain, Protein
HG581_RS07250	COG0786	glutamate:sodium symporter activity
HG581_RS07260	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HG581_RS07300	COG0193	aminoacyl-tRNA hydrolase activity
HG581_RS07310	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HG581_RS07315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HG581_RS07325	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HG581_RS07330	COG0306	phosphate transporter
HG581_RS07335	COG1253	flavin adenine dinucleotide binding
HG581_RS07345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG581_RS07360	COG1739	Uncharacterized protein family UPF0029
HG581_RS07365	COG1981	membrane
HG581_RS07370	COG2226	methyltransferase
HG581_RS07385	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HG581_RS07405	COG0163	prenyltransferase activity
HG581_RS07440	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG581_RS07440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG581_RS07450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HG581_RS07460	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HG581_RS07465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HG581_RS07490	COG0587	DNA-directed DNA polymerase activity
HG581_RS07495	COG1187	pseudouridine synthase activity
HG581_RS07500	COG3118	belongs to the thioredoxin family
HG581_RS07545	COG4772	TonB-dependent receptor
HG581_RS07550	COG0010	Belongs to the arginase family
HG581_RS07555	COG0833	amino acid
HG581_RS07560	COG0686	Belongs to the AlaDH PNT family
HG581_RS07580	COG0497	DNA recombination
HG581_RS07595	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG581_RS07605	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HG581_RS07640	COG0723	plastoquinol--plastocyanin reductase activity
HG581_RS07645	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HG581_RS07655	COG0739	heme binding
HG581_RS07665	COG0285	dihydrofolate synthase activity
HG581_RS07685	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HG581_RS07690	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HG581_RS07695	COG1862	Preprotein translocase
HG581_RS07705	COG1074	ATP-dependent DNA helicase activity
HG581_RS07720	COG0768	penicillin binding
HG581_RS07735	COG1558	bacterial-type flagellum-dependent cell motility
HG581_RS07740	COG1815	bacterial-type flagellum-dependent cell motility
HG581_RS07745	COG0772	Belongs to the SEDS family
HG581_RS07760	COG0450	alkyl hydroperoxide reductase
HG581_RS07770	COG0768	penicillin binding
HG581_RS07795	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HG581_RS07800	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HG581_RS07805	COG0741	lytic transglycosylase activity
HG581_RS07805	COG1388	LysM domain
HG581_RS07810	COG0084	hydrolase, TatD family'
HG581_RS07815	COG0307	riboflavin synthase, alpha
HG581_RS07830	COG2011	ABC-type metal ion transport system permease component
HG581_RS07840	COG0671	phosphoesterase, PA-phosphatase related
HG581_RS07845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HG581_RS07865	COG4786	Flagellar basal body rod
HG581_RS07870	COG4735	regulation of single-species biofilm formation
HG581_RS07890	COG4735	regulation of single-species biofilm formation
HG581_RS07895	COG4735	regulation of single-species biofilm formation