locus-tag	class	description
HG568_RS00015	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HG568_RS00020	COG0288	reversible hydration of carbon dioxide
HG568_RS00060	COG0459	protein refolding
HG568_RS00070	COG0358	DNA primase activity
HG568_RS00075	COG0482	sulfurtransferase activity
HG568_RS00110	COG0835	chemotaxis
HG568_RS00110	COG0784	Response regulator, receiver
HG568_RS00120	COG0671	phosphoesterase, PA-phosphatase related
HG568_RS00125	COG2194	sulfuric ester hydrolase activity
HG568_RS00135	COG0372	Belongs to the citrate synthase family
HG568_RS00140	COG0538	isocitrate dehydrogenase activity
HG568_RS00165	COG0589	response to stress
HG568_RS00170	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HG568_RS00225	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HG568_RS00240	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HG568_RS00245	COG2957	Belongs to the agmatine deiminase family
HG568_RS00275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG568_RS00280	COG0506	proline dehydrogenase activity
HG568_RS00280	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HG568_RS00280	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HG568_RS00355	COG0830	nickel cation binding
HG568_RS00370	COG0804	urea catabolic process
HG568_RS00385	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HG568_RS00395	COG0268	Binds directly to 16S ribosomal RNA
HG568_RS00400	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HG568_RS00415	COG0840	transmembrane signaling receptor activity
HG568_RS00445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG568_RS00450	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HG568_RS00455	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HG568_RS00490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG568_RS00500	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HG568_RS00510	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HG568_RS00530	COG0737	Belongs to the 5'-nucleotidase family
HG568_RS00540	COG0626	cystathionine gamma-synthase activity
HG568_RS00545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HG568_RS00580	COG1420	regulation of RNA biosynthetic process
HG568_RS00600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HG568_RS00605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HG568_RS00605	COG0551	DNA topoisomerase type I activity
HG568_RS00610	COG0731	radical SAM domain protein
HG568_RS00625	COG0574	Belongs to the PEP-utilizing enzyme family
HG568_RS00625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HG568_RS00635	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HG568_RS00670	COG1760	l-serine dehydratase
HG568_RS00675	COG0814	amino acid
HG568_RS00680	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HG568_RS00685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG568_RS00695	COG1139	Iron-sulfur cluster binding protein
HG568_RS00700	COG0247	lactate metabolic process
HG568_RS00705	COG1620	l-lactate permease
HG568_RS00710	COG1620	l-lactate permease
HG568_RS00715	COG1194	a g-specific adenine glycosylase
HG568_RS00720	COG0471	metal ion transport
HG568_RS00725	COG3278	Belongs to the heme-copper respiratory oxidase family
HG568_RS00805	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG568_RS00815	COG0113	porphobilinogen synthase activity
HG568_RS00820	COG0642	Histidine kinase
HG568_RS00825	COG0745	RESPONSE REGULATOR receiver
HG568_RS00840	COG0826	peptidase U32
HG568_RS00855	COG0303	'Molybdopterin
HG568_RS00870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HG568_RS00875	COG0191	fructose-bisphosphate aldolase activity
HG568_RS00905	COG2089	acid synthase
HG568_RS00910	COG1136	(ABC) transporter
HG568_RS00915	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HG568_RS00955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HG568_RS00960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HG568_RS00965	COG1053	succinate dehydrogenase
HG568_RS00980	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HG568_RS00985	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG568_RS01035	COG0489	protein tyrosine kinase activity
HG568_RS01050	COG0326	Molecular chaperone. Has ATPase activity
HG568_RS01055	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG568_RS01070	COG0471	metal ion transport
HG568_RS01075	COG0575	Belongs to the CDS family
HG568_RS01095	COG1881	PFAM PEBP family protein
HG568_RS01105	COG1104	cysteine desulfurase activity
HG568_RS01120	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HG568_RS01125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG568_RS01125	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG568_RS01130	COG0730	response to heat
HG568_RS01140	COG0659	secondary active sulfate transmembrane transporter activity
HG568_RS01170	COG0754	glutathionylspermidine amidase activity
HG568_RS01180	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG568_RS01190	COG0181	hydroxymethylbilane synthase activity
HG568_RS01195	COG0442	prolyl-tRNA aminoacylation
HG568_RS01220	COG0783	Belongs to the Dps family
HG568_RS01225	COG0642	Histidine kinase
HG568_RS01230	COG3951	Flagellar rod assembly protein muramidase FlgJ
HG568_RS01255	COG4172	Belongs to the ABC transporter superfamily
HG568_RS01260	COG4239	(ABC) transporter, permease
HG568_RS01295	COG0750	zinc metalloprotease
HG568_RS01315	COG0542	response to heat
HG568_RS01320	COG0785	Cytochrome C biogenesis protein
HG568_RS01325	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HG568_RS01330	COG0402	S-adenosylhomocysteine deaminase activity
HG568_RS01365	COG0727	PFAM Uncharacterised protein family (UPF0153)
HG568_RS01375	COG0134	indole-3-glycerol-phosphate synthase activity
HG568_RS01385	COG0248	Ppx GppA phosphatase
HG568_RS01390	COG0859	PFAM glycosyl transferase family 9
HG568_RS01420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HG568_RS01425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG568_RS01445	COG0019	diaminopimelate decarboxylase activity
HG568_RS01460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG568_RS01485	COG0747	negative chemotaxis
HG568_RS01490	COG0601	transmembrane transport
HG568_RS01495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HG568_RS01500	COG0444	Belongs to the ABC transporter superfamily
HG568_RS01525	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HG568_RS01540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG568_RS01545	COG0726	polysaccharide deacetylase
HG568_RS01555	COG0523	cobalamin synthesis protein
HG568_RS01565	COG0748	coenzyme F420 binding
HG568_RS01600	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HG568_RS01605	COG3980	spore coat polysaccharide biosynthesis protein
HG568_RS01610	COG3980	spore coat polysaccharide biosynthesis protein
HG568_RS01615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HG568_RS01620	COG1663	tetraacyldisaccharide 4'-kinase activity
HG568_RS01640	COG2894	cell division
HG568_RS01660	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG568_RS01700	COG0564	pseudouridine synthase activity
HG568_RS01705	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HG568_RS01705	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HG568_RS01710	COG0504	CTP synthase activity
HG568_RS01720	COG1766	The M ring may be actively involved in energy transduction
HG568_RS01725	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG568_RS01735	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HG568_RS01755	COG4786	Flagellar basal body rod
HG568_RS01760	COG0477	Major facilitator Superfamily
HG568_RS01765	COG1674	ftsk spoiiie
HG568_RS01775	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HG568_RS01780	COG0196	riboflavin kinase activity
HG568_RS01785	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HG568_RS01805	COG1132	(ABC) transporter
HG568_RS01820	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HG568_RS01840	COG2608	mercury ion transmembrane transporter activity
HG568_RS01845	COG2217	Heavy metal translocating P-type atpase
HG568_RS01850	COG1183	phosphatidylcholine synthase activity
HG568_RS01860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG568_RS01870	COG0745	RESPONSE REGULATOR receiver
HG568_RS01895	COG0357	Ribosomal RNA small subunit methyltransferase G
HG568_RS01905	COG0805	protein transport
HG568_RS01950	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HG568_RS01960	COG0083	homoserine kinase activity
HG568_RS01990	COG1408	metallophosphoesterase
HG568_RS01995	COG0745	RESPONSE REGULATOR receiver
HG568_RS02000	COG2404	hydrolase activity, acting on ester bonds
HG568_RS02005	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG568_RS02010	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HG568_RS02025	COG0006	proline dipeptidase activity
HG568_RS02030	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HG568_RS02035	COG1419	protein localization to endoplasmic reticulum
HG568_RS02040	COG0455	bacterial-type flagellum organization
HG568_RS02055	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG568_RS02060	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG568_RS02060	COG1776	CheC inhibitor of MCP methylation
HG568_RS02075	COG0735	belongs to the Fur family
HG568_RS02080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG568_RS02080	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HG568_RS02085	COG0789	Transcriptional regulator
HG568_RS02090	COG0484	heat shock protein binding
HG568_RS02105	COG0745	RESPONSE REGULATOR receiver
HG568_RS02120	COG0833	amino acid
HG568_RS02125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HG568_RS02135	COG1028	Short-chain dehydrogenase reductase Sdr
HG568_RS02155	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HG568_RS02180	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HG568_RS02260	COG1217	gtp-binding protein TYPA
HG568_RS02325	COG0753	catalase activity
HG568_RS02340	COG2824	Alkylphosphonate utilization operon protein PhnA
HG568_RS02345	COG2134	cdp-diacylglycerol pyrophosphatase
HG568_RS02350	COG1749	Flagellar hook protein flgE
HG568_RS02355	COG0375	protein maturation
HG568_RS02375	COG0756	dUTP diphosphatase activity
HG568_RS02390	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HG568_RS02400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HG568_RS02405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG568_RS02425	COG0488	(ABC) transporter
HG568_RS02435	COG0671	phosphoesterase, PA-phosphatase related
HG568_RS02445	COG0732	type I restriction modification DNA specificity domain
HG568_RS02460	COG0351	phosphomethylpyrimidine kinase
HG568_RS02475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HG568_RS02480	COG1086	Polysaccharide biosynthesis protein
HG568_RS02505	COG0776	regulation of translation
HG568_RS02525	COG0237	dephospho-CoA kinase activity
HG568_RS02535	COG0516	GMP reductase activity
HG568_RS02535	COG0517	IMP dehydrogenase activity
HG568_RS02545	COG0724	RNA recognition motif
HG568_RS02555	COG0492	ferredoxin-NADP+ reductase activity
HG568_RS02560	COG3118	belongs to the thioredoxin family
HG568_RS02570	COG0460	homoserine dehydrogenase
HG568_RS02590	COG0517	IMP dehydrogenase activity
HG568_RS02590	COG1125	glycine betaine transport
HG568_RS02595	COG1732	Glycine betaine
HG568_RS02605	COG1360	Flagellar Motor Protein
HG568_RS02610	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HG568_RS02615	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HG568_RS02620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG568_RS02640	COG1580	Controls the rotational direction of flagella during chemotaxis
HG568_RS02645	COG0736	holo-[acyl-carrier-protein] synthase activity
HG568_RS02660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG568_RS02660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG568_RS02680	COG0314	molybdopterin synthase activity
HG568_RS02685	COG0521	Mo-molybdopterin cofactor biosynthetic process
HG568_RS02690	COG0315	cyclic pyranopterin monophosphate synthase activity
HG568_RS02720	COG0606	chelatase, subunit chli
HG568_RS02725	COG2217	Heavy metal translocating P-type atpase
HG568_RS02750	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HG568_RS02780	COG1049	propionate catabolic process, 2-methylcitrate cycle
HG568_RS02795	COG1758	RNA polymerase activity
HG568_RS02800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HG568_RS02805	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HG568_RS02815	COG0860	N-Acetylmuramoyl-L-alanine amidase
HG568_RS02825	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG568_RS02830	COG0746	molybdenum cofactor guanylyltransferase activity
HG568_RS02835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HG568_RS02855	COG0552	protein localization to endoplasmic reticulum
HG568_RS02875	COG0534	Mate efflux family protein
HG568_RS02880	COG2056	Na+-H+ antiporter family
HG568_RS02910	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HG568_RS02930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HG568_RS02935	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HG568_RS02945	COG0564	pseudouridine synthase activity
HG568_RS02955	COG0772	Belongs to the SEDS family
HG568_RS02965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG568_RS02975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HG568_RS02990	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HG568_RS02995	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HG568_RS03000	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HG568_RS03030	COG0037	tRNA processing
HG568_RS03035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG568_RS03050	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HG568_RS03055	COG0252	asparaginase activity
HG568_RS03075	COG1279	arginine transmembrane transporter activity
HG568_RS03080	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HG568_RS03090	COG1137	ATPase activity
HG568_RS03095	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HG568_RS03105	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HG568_RS03125	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HG568_RS03130	COG2204	response regulator
HG568_RS03140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HG568_RS03145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HG568_RS03155	COG4647	ligase activity
HG568_RS03160	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HG568_RS03165	COG0145	ligase activity
HG568_RS03175	COG2031	fatty acid transporter
HG568_RS03180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HG568_RS03185	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HG568_RS03190	COG0183	Belongs to the thiolase family
HG568_RS03200	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HG568_RS03210	COG1338	Plays a role in the flagellum-specific transport system
HG568_RS03215	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HG568_RS03230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG568_RS03240	COG0730	response to heat
HG568_RS03250	COG4974	Belongs to the 'phage' integrase family
HG568_RS03290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG568_RS03305	COG0571	ribonuclease III activity
HG568_RS03310	COG0328	RNA-DNA hybrid ribonuclease activity
HG568_RS03325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HG568_RS03335	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HG568_RS03340	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HG568_RS03345	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HG568_RS03350	COG1528	Iron-storage protein
HG568_RS03355	COG0560	Phosphoserine phosphatase
HG568_RS03370	COG1027	Aspartate ammonia-lyase
HG568_RS03405	COG0778	Nitroreductase
HG568_RS03410	COG0617	tRNA 3'-terminal CCA addition
HG568_RS03435	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HG568_RS03440	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HG568_RS03445	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HG568_RS03450	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HG568_RS03455	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HG568_RS03460	COG2249	NAD(P)H dehydrogenase (quinone) activity
HG568_RS03475	COG2171	N-acyltransferase activity
HG568_RS03485	COG0436	Aminotransferase
HG568_RS03500	COG1193	negative regulation of DNA recombination
HG568_RS03505	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HG568_RS03520	COG3306	glycosyltransferase involved in LPS biosynthesis
HG568_RS03535	COG0835	chemotaxis
HG568_RS03535	COG0784	Response regulator, receiver
HG568_RS03550	COG1131	(ABC) transporter
HG568_RS03560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG568_RS03600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HG568_RS03610	COG0840	transmembrane signaling receptor activity
HG568_RS03615	COG0156	8-amino-7-oxononanoate synthase activity
HG568_RS03620	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HG568_RS03655	COG1013	pyruvate-flavodoxin oxidoreductase activity
HG568_RS03660	COG0674	pyruvate-flavodoxin oxidoreductase activity
HG568_RS03660	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HG568_RS03680	COG1918	ferrous iron import across plasma membrane
HG568_RS03685	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HG568_RS03690	COG1776	CheC inhibitor of MCP methylation
HG568_RS03690	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG568_RS03730	COG0681	Belongs to the peptidase S26 family
HG568_RS03735	COG1994	Peptidase M50
HG568_RS03740	COG0698	ribose 5-phosphate isomerase
HG568_RS03760	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HG568_RS03765	COG0012	GTP binding
HG568_RS03775	COG0628	permease
HG568_RS03805	COG1028	Short-chain dehydrogenase reductase Sdr
HG568_RS03815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG568_RS03845	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HG568_RS03855	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HG568_RS03865	COG1842	Phage shock protein A
HG568_RS03885	COG3451	type IV secretory pathway VirB4
HG568_RS04045	COG0174	glutamine synthetase
HG568_RS04060	COG0277	FAD linked oxidase domain protein
HG568_RS04075	COG1196	nuclear chromosome segregation
HG568_RS04075	COG0741	lytic transglycosylase activity
HG568_RS04075	COG0739	heme binding
HG568_RS04090	COG0187	DNA topoisomerase II activity
HG568_RS04095	COG0592	DNA-directed DNA polymerase activity
HG568_RS04105	COG0733	neurotransmitter:sodium symporter activity
HG568_RS04110	COG0733	neurotransmitter:sodium symporter activity
HG568_RS04115	COG0824	Thioesterase
HG568_RS04125	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HG568_RS04170	COG0728	peptidoglycan biosynthetic process
HG568_RS04185	COG1120	ATPase activity
HG568_RS04190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HG568_RS04195	COG0300	oxidoreductase activity
HG568_RS04200	COG1607	acyl-coa hydrolase
HG568_RS04205	COG3041	Addiction module toxin RelE StbE family
HG568_RS04235	COG0409	Hydrogenase expression formation protein
HG568_RS04240	COG0298	carbon dioxide binding
HG568_RS04245	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HG568_RS04255	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HG568_RS04260	COG0280	phosphate acetyltransferase
HG568_RS04270	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HG568_RS04275	COG1749	Flagellar hook protein flgE
HG568_RS04275	COG1749	Flagellar hook protein flgE
HG568_RS04320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HG568_RS04325	COG0670	Belongs to the BI1 family
HG568_RS04330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG568_RS04345	COG1942	4-Oxalocrotonate Tautomerase
HG568_RS04370	COG0142	geranyltranstransferase activity
HG568_RS04385	COG0720	synthase
HG568_RS04390	COG0602	queuosine metabolic process
HG568_RS04415	COG0765	amino acid transport
HG568_RS04420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HG568_RS04430	COG1115	amino acid carrier protein
HG568_RS04435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG568_RS04440	COG0251	oxidation-reduction process
HG568_RS04470	COG1757	Na H antiporter
HG568_RS04490	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HG568_RS04500	COG1546	Belongs to the CinA family
HG568_RS04500	COG1058	Belongs to the CinA family
HG568_RS04520	COG0564	pseudouridine synthase activity
HG568_RS04525	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HG568_RS04525	COG1519	Transferase
HG568_RS04535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HG568_RS04555	COG1160	GTP binding
HG568_RS04565	COG3309	Virulence-associated protein D
HG568_RS04600	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HG568_RS04605	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HG568_RS04610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HG568_RS04620	COG0849	cell division
HG568_RS04625	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HG568_RS04640	COG0668	transmembrane transport
HG568_RS04680	COG4962	Type ii secretion system protein e
HG568_RS04705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HG568_RS04730	COG1192	Involved in chromosome partitioning
HG568_RS04780	COG3177	Filamentation induced by cAMP protein fic
HG568_RS04785	COG4974	Belongs to the 'phage' integrase family
HG568_RS04820	COG1166	arginine decarboxylase activity
HG568_RS04835	COG0500	methyltransferase
HG568_RS04845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG568_RS04845	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG568_RS04850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HG568_RS04855	COG0668	transmembrane transport
HG568_RS04905	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG568_RS04910	COG0537	adenosine 5'-monophosphoramidase activity
HG568_RS04920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG568_RS04920	COG0072	phenylalanine-tRNA ligase activity
HG568_RS04925	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HG568_RS04935	COG0539	negative regulation of cytoplasmic translation
HG568_RS04935	COG1185	polyribonucleotide nucleotidyltransferase activity
HG568_RS04945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HG568_RS04950	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HG568_RS04955	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HG568_RS04965	COG0784	Response regulator, receiver
HG568_RS04965	COG0835	chemotaxis
HG568_RS04970	COG0643	Histidine kinase
HG568_RS04970	COG0784	Response regulator, receiver
HG568_RS04970	COG2198	Histidine kinase
HG568_RS04975	COG0835	chemotaxis
HG568_RS04980	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HG568_RS04985	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HG568_RS04995	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HG568_RS05020	COG0501	Belongs to the peptidase M48B family
HG568_RS05025	COG2890	protein-(glutamine-N5) methyltransferase activity
HG568_RS05030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HG568_RS05040	COG1333	cytochrome c biogenesis protein
HG568_RS05040	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HG568_RS05060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HG568_RS05080	COG0511	ligase activity, forming carbon-carbon bonds
HG568_RS05085	COG0439	Biotin carboxylase
HG568_RS05105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HG568_RS05115	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG568_RS05155	COG4221	oxidoreductase activity
HG568_RS05160	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG568_RS05165	COG0800	Aldolase
HG568_RS05170	COG0129	dihydroxy-acid dehydratase activity
HG568_RS05175	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HG568_RS05180	COG0363	glucosamine-6-phosphate deaminase activity
HG568_RS05190	COG1064	alcohol dehydrogenase
HG568_RS05215	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HG568_RS05225	COG0674	pyruvate-flavodoxin oxidoreductase activity
HG568_RS05230	COG1013	pyruvate-flavodoxin oxidoreductase activity
HG568_RS05235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HG568_RS05260	COG0405	Gamma-glutamyltransferase
HG568_RS05290	COG1047	Peptidyl-prolyl cis-trans
HG568_RS05300	COG2885	chlorophyll binding
HG568_RS05305	COG0823	Involved in the tonB-independent uptake of proteins
HG568_RS05315	COG0848	biopolymer transport protein
HG568_RS05320	COG0811	peptide transport
HG568_RS05330	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HG568_RS05335	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HG568_RS05360	COG1475	DNA binding
HG568_RS05365	COG1192	Involved in chromosome partitioning
HG568_RS05370	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HG568_RS05370	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HG568_RS05375	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HG568_RS05425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HG568_RS05430	COG0525	valine-tRNA ligase activity
HG568_RS05455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HG568_RS05460	COG2184	nucleotidyltransferase activity
HG568_RS05480	COG0716	FMN binding
HG568_RS05495	COG0492	ferredoxin-NADP+ reductase activity
HG568_RS05515	COG1966	Carbon starvation protein
HG568_RS05525	COG0765	amino acid transport
HG568_RS05530	COG1126	abc transporter atp-binding protein
HG568_RS05545	COG0738	Major facilitator superfamily
HG568_RS05550	COG2252	PERMEase
HG568_RS05570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HG568_RS05580	COG2814	Major facilitator Superfamily
HG568_RS05585	COG0037	tRNA processing
HG568_RS05590	COG0569	domain protein
HG568_RS05590	COG0475	glutathione-regulated potassium exporter activity
HG568_RS05615	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HG568_RS05625	COG0859	PFAM glycosyl transferase family 9
HG568_RS05675	COG0250	Participates in transcription elongation, termination and antitermination
HG568_RS05720	COG1132	(ABC) transporter
HG568_RS05740	COG1045	serine acetyltransferase
HG568_RS05770	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HG568_RS05780	COG0151	Belongs to the GarS family
HG568_RS05785	COG1131	(ABC) transporter
HG568_RS05790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HG568_RS05815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG568_RS05820	COG2863	cytochrome
HG568_RS05830	COG0527	aspartate kinase activity
HG568_RS05845	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HG568_RS05855	COG0697	spore germination
HG568_RS05870	COG0505	Belongs to the CarA family
HG568_RS05875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG568_RS05915	COG0629	single-stranded DNA binding
HG568_RS05925	COG1466	dna polymerase III delta subunit
HG568_RS05930	COG0557	exoribonuclease II activity
HG568_RS05945	COG4174	ABC transporter (Permease)
HG568_RS05950	COG4166	transmembrane transport
HG568_RS05955	COG0180	Tryptophanyl-tRNA synthetase
HG568_RS05965	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HG568_RS05975	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HG568_RS05985	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG568_RS05990	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG568_RS06000	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG568_RS06035	COG0839	Belongs to the complex I subunit 6 family
HG568_RS06045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HG568_RS06055	COG1007	ATP synthesis coupled electron transport
HG568_RS06080	COG0133	tryptophan synthase activity
HG568_RS06085	COG0135	phosphoribosylanthranilate isomerase activity
HG568_RS06085	COG0134	indole-3-glycerol-phosphate synthase activity
HG568_RS06095	COG0512	Glutamine amidotransferase of anthranilate synthase
HG568_RS06100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG568_RS06105	COG0859	PFAM glycosyl transferase family 9
HG568_RS06115	COG2353	YceI-like domain
HG568_RS06120	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HG568_RS06150	COG0202	RNA polymerase activity
HG568_RS06175	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HG568_RS06180	COG0024	Methionine aminopeptidase
HG568_RS06185	COG0201	protein transport
HG568_RS06220	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG568_RS06240	COG0255	Belongs to the universal ribosomal protein uL29 family
HG568_RS06280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HG568_RS06310	COG0114	fumarate hydratase activity
HG568_RS06330	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HG568_RS06335	COG1687	branched-chain amino acid
HG568_RS06340	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HG568_RS06345	COG0484	heat shock protein binding
HG568_RS06375	COG0811	peptide transport
HG568_RS06380	COG0848	biopolymer transport protein
HG568_RS06385	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HG568_RS06395	COG0861	Integral membrane protein TerC family
HG568_RS06400	COG0598	Magnesium transport protein CorA
HG568_RS06405	COG0126	phosphoglycerate kinase activity
HG568_RS06410	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG568_RS06420	COG0204	Acyl-transferase
HG568_RS06430	COG0793	Belongs to the peptidase S41A family
HG568_RS06460	COG0157	Belongs to the NadC ModD family
HG568_RS06465	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HG568_RS06485	COG0109	protoheme IX farnesyltransferase activity
HG568_RS06495	COG0305	Participates in initiation and elongation during chromosome replication
HG568_RS06500	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HG568_RS06500	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HG568_RS06505	COG0642	Histidine kinase
HG568_RS06510	COG0745	RESPONSE REGULATOR receiver
HG568_RS06525	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HG568_RS06530	COG0745	RESPONSE REGULATOR receiver
HG568_RS06535	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HG568_RS06550	COG1077	Cell shape determining protein MreB Mrl
HG568_RS06555	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HG568_RS06560	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG568_RS06565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HG568_RS06580	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HG568_RS06585	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HG568_RS06590	COG0287	Prephenate dehydrogenase
HG568_RS06600	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HG568_RS06605	COG3421	Type III restriction
HG568_RS06640	COG1295	ribonuclease BN
HG568_RS06675	COG0799	negative regulation of ribosome biogenesis
HG568_RS06680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HG568_RS06700	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HG568_RS06705	COG1987	bacterial-type flagellum assembly
HG568_RS06710	COG1157	protein secretion by the type III secretion system
HG568_RS06715	COG4962	Type ii secretion system protein e
HG568_RS06725	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HG568_RS06745	COG0517	IMP dehydrogenase activity
HG568_RS06745	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HG568_RS06750	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HG568_RS06765	COG0732	type I restriction modification DNA specificity domain
HG568_RS06770	COG0788	formyltetrahydrofolate deformylase activity
HG568_RS06815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG568_RS06835	COG0811	peptide transport
HG568_RS06840	COG0848	biopolymer transport protein
HG568_RS06855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HG568_RS06860	COG0706	membrane insertase activity
HG568_RS06870	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG568_RS06905	COG3118	belongs to the thioredoxin family
HG568_RS06910	COG1187	pseudouridine synthase activity
HG568_RS06915	COG0587	DNA-directed DNA polymerase activity
HG568_RS06940	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HG568_RS06945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HG568_RS06955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HG568_RS06965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG568_RS06965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG568_RS06995	COG0163	prenyltransferase activity
HG568_RS07030	COG2226	methyltransferase
HG568_RS07035	COG1981	membrane
HG568_RS07040	COG1739	Uncharacterized protein family UPF0029
HG568_RS07055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG568_RS07065	COG1253	flavin adenine dinucleotide binding
HG568_RS07070	COG0306	phosphate transporter
HG568_RS07075	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HG568_RS07085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HG568_RS07115	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HG568_RS07135	COG2217	Heavy metal translocating P-type atpase
HG568_RS07140	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HG568_RS07150	COG0786	glutamate:sodium symporter activity
HG568_RS07160	COG0348	domain, Protein
HG568_RS07165	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HG568_RS07185	COG1921	L-seryl-tRNASec selenium transferase activity
HG568_RS07190	COG0195	Participates in both transcription termination and antitermination
HG568_RS07210	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HG568_RS07225	COG0708	Exodeoxyribonuclease III
HG568_RS07255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HG568_RS07260	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HG568_RS07300	COG0010	Belongs to the arginase family
HG568_RS07305	COG0833	amino acid
HG568_RS07310	COG0686	Belongs to the AlaDH PNT family
HG568_RS07330	COG0497	DNA recombination
HG568_RS07350	COG2176	DNA-directed DNA polymerase activity
HG568_RS07355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HG568_RS07400	COG1074	ATP-dependent DNA helicase activity
HG568_RS07410	COG1862	Preprotein translocase
HG568_RS07415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HG568_RS07420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HG568_RS07430	COG0495	leucyl-tRNA aminoacylation
HG568_RS07440	COG0285	dihydrofolate synthase activity
HG568_RS07450	COG0739	heme binding
HG568_RS07460	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HG568_RS07465	COG0723	plastoquinol--plastocyanin reductase activity
HG568_RS07490	COG0768	penicillin binding
HG568_RS07505	COG1558	bacterial-type flagellum-dependent cell motility
HG568_RS07510	COG1815	bacterial-type flagellum-dependent cell motility
HG568_RS07515	COG0772	Belongs to the SEDS family
HG568_RS07530	COG0450	alkyl hydroperoxide reductase
HG568_RS07540	COG0768	penicillin binding
HG568_RS07565	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HG568_RS07570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HG568_RS07575	COG1388	LysM domain
HG568_RS07575	COG0741	lytic transglycosylase activity
HG568_RS07580	COG0084	hydrolase, TatD family'
HG568_RS07585	COG0307	riboflavin synthase, alpha
HG568_RS07600	COG2011	ABC-type metal ion transport system permease component
HG568_RS07610	COG0671	phosphoesterase, PA-phosphatase related
HG568_RS07615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HG568_RS07635	COG4786	Flagellar basal body rod
HG568_RS07640	COG4735	regulation of single-species biofilm formation
HG568_RS07650	COG4735	regulation of single-species biofilm formation