locus-tag	class	description
HG570_RS00020	COG0288	reversible hydration of carbon dioxide
HG570_RS00060	COG0459	protein refolding
HG570_RS00065	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HG570_RS00070	COG0358	DNA primase activity
HG570_RS00075	COG0482	sulfurtransferase activity
HG570_RS00110	COG0835	chemotaxis
HG570_RS00110	COG0784	Response regulator, receiver
HG570_RS00120	COG0671	phosphoesterase, PA-phosphatase related
HG570_RS00125	COG2194	sulfuric ester hydrolase activity
HG570_RS00135	COG0372	Belongs to the citrate synthase family
HG570_RS00140	COG0538	isocitrate dehydrogenase activity
HG570_RS00160	COG0589	response to stress
HG570_RS00165	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HG570_RS00170	COG0542	response to heat
HG570_RS00220	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HG570_RS00235	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HG570_RS00260	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG570_RS00265	COG0506	proline dehydrogenase activity
HG570_RS00265	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HG570_RS00265	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HG570_RS00315	COG1674	ftsk spoiiie
HG570_RS00330	COG0830	nickel cation binding
HG570_RS00345	COG0804	urea catabolic process
HG570_RS00350	COG0832	Belongs to the urease beta subunit family
HG570_RS00350	COG0831	urea catabolic process
HG570_RS00360	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HG570_RS00375	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HG570_RS00390	COG0840	transmembrane signaling receptor activity
HG570_RS00425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG570_RS00430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HG570_RS00435	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HG570_RS00470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG570_RS00480	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HG570_RS00490	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HG570_RS00505	COG0840	transmembrane signaling receptor activity
HG570_RS00510	COG0737	Belongs to the 5'-nucleotidase family
HG570_RS00520	COG0626	cystathionine gamma-synthase activity
HG570_RS00525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HG570_RS00545	COG1420	regulation of RNA biosynthetic process
HG570_RS00565	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HG570_RS00570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HG570_RS00570	COG0551	DNA topoisomerase type I activity
HG570_RS00575	COG0731	radical SAM domain protein
HG570_RS00590	COG0574	Belongs to the PEP-utilizing enzyme family
HG570_RS00590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HG570_RS00600	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HG570_RS00630	COG1760	l-serine dehydratase
HG570_RS00635	COG0814	amino acid
HG570_RS00640	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HG570_RS00645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG570_RS00655	COG1139	Iron-sulfur cluster binding protein
HG570_RS00660	COG0247	lactate metabolic process
HG570_RS00665	COG1620	l-lactate permease
HG570_RS00670	COG1620	l-lactate permease
HG570_RS00675	COG1194	a g-specific adenine glycosylase
HG570_RS00680	COG0471	metal ion transport
HG570_RS00685	COG3278	Belongs to the heme-copper respiratory oxidase family
HG570_RS00765	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG570_RS00775	COG0113	porphobilinogen synthase activity
HG570_RS00780	COG0642	Histidine kinase
HG570_RS00785	COG0745	RESPONSE REGULATOR receiver
HG570_RS00800	COG0826	peptidase U32
HG570_RS00815	COG0303	'Molybdopterin
HG570_RS00830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HG570_RS00835	COG0191	fructose-bisphosphate aldolase activity
HG570_RS00845	COG2089	acid synthase
HG570_RS00850	COG1136	(ABC) transporter
HG570_RS00855	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HG570_RS00895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HG570_RS00900	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HG570_RS00905	COG1053	succinate dehydrogenase
HG570_RS00920	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HG570_RS00925	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG570_RS00980	COG0489	protein tyrosine kinase activity
HG570_RS00995	COG0326	Molecular chaperone. Has ATPase activity
HG570_RS01000	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG570_RS01015	COG0471	metal ion transport
HG570_RS01020	COG0575	Belongs to the CDS family
HG570_RS01035	COG1881	PFAM PEBP family protein
HG570_RS01045	COG1104	cysteine desulfurase activity
HG570_RS01060	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HG570_RS01065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG570_RS01065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG570_RS01075	COG0730	response to heat
HG570_RS01085	COG0659	secondary active sulfate transmembrane transporter activity
HG570_RS01115	COG0754	glutathionylspermidine amidase activity
HG570_RS01125	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG570_RS01165	COG0783	Belongs to the Dps family
HG570_RS01170	COG0642	Histidine kinase
HG570_RS01175	COG3951	Flagellar rod assembly protein muramidase FlgJ
HG570_RS01200	COG4172	Belongs to the ABC transporter superfamily
HG570_RS01205	COG4239	(ABC) transporter, permease
HG570_RS01240	COG0750	zinc metalloprotease
HG570_RS01270	COG0542	response to heat
HG570_RS01275	COG0785	Cytochrome C biogenesis protein
HG570_RS01280	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HG570_RS01285	COG0402	S-adenosylhomocysteine deaminase activity
HG570_RS01320	COG0727	PFAM Uncharacterised protein family (UPF0153)
HG570_RS01330	COG0134	indole-3-glycerol-phosphate synthase activity
HG570_RS01340	COG0248	Ppx GppA phosphatase
HG570_RS01345	COG0859	PFAM glycosyl transferase family 9
HG570_RS01375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HG570_RS01380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG570_RS01400	COG0019	diaminopimelate decarboxylase activity
HG570_RS01415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG570_RS01440	COG0747	negative chemotaxis
HG570_RS01445	COG0601	transmembrane transport
HG570_RS01450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HG570_RS01455	COG0444	Belongs to the ABC transporter superfamily
HG570_RS01460	COG4608	Belongs to the ABC transporter superfamily
HG570_RS01480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HG570_RS01495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG570_RS01520	COG0523	cobalamin synthesis protein
HG570_RS01530	COG0748	coenzyme F420 binding
HG570_RS01540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HG570_RS01565	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HG570_RS01570	COG3980	spore coat polysaccharide biosynthesis protein
HG570_RS01575	COG3980	spore coat polysaccharide biosynthesis protein
HG570_RS01580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HG570_RS01585	COG1663	tetraacyldisaccharide 4'-kinase activity
HG570_RS01605	COG2894	cell division
HG570_RS01610	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HG570_RS01615	COG0758	DNA mediated transformation
HG570_RS01615	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HG570_RS01660	COG0564	pseudouridine synthase activity
HG570_RS01665	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HG570_RS01665	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HG570_RS01670	COG0504	CTP synthase activity
HG570_RS01680	COG1766	The M ring may be actively involved in energy transduction
HG570_RS01685	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG570_RS01695	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HG570_RS01710	COG4786	Flagellar basal body rod
HG570_RS01715	COG0477	Major facilitator Superfamily
HG570_RS01720	COG1674	ftsk spoiiie
HG570_RS01730	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HG570_RS01735	COG0196	riboflavin kinase activity
HG570_RS01740	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HG570_RS01760	COG1132	(ABC) transporter
HG570_RS01775	COG1106	Psort location Cytoplasmic, score
HG570_RS01785	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HG570_RS01800	COG2608	mercury ion transmembrane transporter activity
HG570_RS01805	COG2217	Heavy metal translocating P-type atpase
HG570_RS01810	COG1183	phosphatidylcholine synthase activity
HG570_RS01820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG570_RS01830	COG0745	RESPONSE REGULATOR receiver
HG570_RS01855	COG0357	Ribosomal RNA small subunit methyltransferase G
HG570_RS01865	COG0805	protein transport
HG570_RS01920	COG0083	homoserine kinase activity
HG570_RS01950	COG1408	metallophosphoesterase
HG570_RS01955	COG0745	RESPONSE REGULATOR receiver
HG570_RS01960	COG2404	hydrolase activity, acting on ester bonds
HG570_RS01965	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG570_RS01970	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HG570_RS01985	COG0006	proline dipeptidase activity
HG570_RS01990	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HG570_RS01995	COG1419	protein localization to endoplasmic reticulum
HG570_RS02000	COG0455	bacterial-type flagellum organization
HG570_RS02015	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG570_RS02020	COG1776	CheC inhibitor of MCP methylation
HG570_RS02020	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG570_RS02035	COG0735	belongs to the Fur family
HG570_RS02040	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG570_RS02040	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HG570_RS02045	COG0789	Transcriptional regulator
HG570_RS02050	COG0484	heat shock protein binding
HG570_RS02065	COG0745	RESPONSE REGULATOR receiver
HG570_RS02080	COG0833	amino acid
HG570_RS02085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HG570_RS02095	COG1028	Short-chain dehydrogenase reductase Sdr
HG570_RS02115	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HG570_RS02135	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HG570_RS02215	COG1217	gtp-binding protein TYPA
HG570_RS02290	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HG570_RS02300	COG0824	Thioesterase
HG570_RS02305	COG0733	neurotransmitter:sodium symporter activity
HG570_RS02310	COG0733	neurotransmitter:sodium symporter activity
HG570_RS02320	COG0592	DNA-directed DNA polymerase activity
HG570_RS02325	COG0187	DNA topoisomerase II activity
HG570_RS02340	COG1196	nuclear chromosome segregation
HG570_RS02340	COG0741	lytic transglycosylase activity
HG570_RS02340	COG0739	heme binding
HG570_RS02355	COG0277	FAD linked oxidase domain protein
HG570_RS02370	COG0174	glutamine synthetase
HG570_RS02375	COG3586	endonuclease activity
HG570_RS02525	COG3451	type IV secretory pathway VirB4
HG570_RS02545	COG1842	Phage shock protein A
HG570_RS02555	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HG570_RS02565	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HG570_RS02595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG570_RS02605	COG1028	Short-chain dehydrogenase reductase Sdr
HG570_RS02635	COG0628	permease
HG570_RS02645	COG0012	GTP binding
HG570_RS02670	COG0698	ribose 5-phosphate isomerase
HG570_RS02675	COG1994	Peptidase M50
HG570_RS02680	COG0681	Belongs to the peptidase S26 family
HG570_RS02685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HG570_RS02720	COG1776	CheC inhibitor of MCP methylation
HG570_RS02720	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG570_RS02725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HG570_RS02730	COG1918	ferrous iron import across plasma membrane
HG570_RS02750	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HG570_RS02750	COG0674	pyruvate-flavodoxin oxidoreductase activity
HG570_RS02755	COG1013	pyruvate-flavodoxin oxidoreductase activity
HG570_RS02790	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HG570_RS02795	COG0156	8-amino-7-oxononanoate synthase activity
HG570_RS02800	COG0840	transmembrane signaling receptor activity
HG570_RS02810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HG570_RS02850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG570_RS02875	COG0784	Response regulator, receiver
HG570_RS02875	COG0835	chemotaxis
HG570_RS02890	COG3306	glycosyltransferase involved in LPS biosynthesis
HG570_RS02905	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HG570_RS02910	COG1193	negative regulation of DNA recombination
HG570_RS02925	COG0436	Aminotransferase
HG570_RS02935	COG2171	N-acyltransferase activity
HG570_RS02950	COG2249	NAD(P)H dehydrogenase (quinone) activity
HG570_RS02955	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HG570_RS02960	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HG570_RS02965	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HG570_RS02970	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HG570_RS02975	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HG570_RS03000	COG0617	tRNA 3'-terminal CCA addition
HG570_RS03005	COG0778	Nitroreductase
HG570_RS03010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG570_RS03040	COG1027	Aspartate ammonia-lyase
HG570_RS03055	COG0560	Phosphoserine phosphatase
HG570_RS03060	COG1528	Iron-storage protein
HG570_RS03065	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HG570_RS03075	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HG570_RS03100	COG0328	RNA-DNA hybrid ribonuclease activity
HG570_RS03105	COG0571	ribonuclease III activity
HG570_RS03120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG570_RS03155	COG4974	Belongs to the 'phage' integrase family
HG570_RS03165	COG0730	response to heat
HG570_RS03175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG570_RS03195	COG1338	Plays a role in the flagellum-specific transport system
HG570_RS03205	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HG570_RS03215	COG0183	Belongs to the thiolase family
HG570_RS03220	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HG570_RS03225	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HG570_RS03230	COG2031	fatty acid transporter
HG570_RS03240	COG0145	ligase activity
HG570_RS03245	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HG570_RS03250	COG4647	ligase activity
HG570_RS03260	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HG570_RS03265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HG570_RS03275	COG2204	response regulator
HG570_RS03285	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HG570_RS03305	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HG570_RS03325	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HG570_RS03330	COG1137	ATPase activity
HG570_RS03340	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HG570_RS03345	COG1279	arginine transmembrane transporter activity
HG570_RS03360	COG0252	asparaginase activity
HG570_RS03365	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HG570_RS03380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG570_RS03385	COG0037	tRNA processing
HG570_RS03420	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HG570_RS03425	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HG570_RS03430	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HG570_RS03445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HG570_RS03455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG570_RS03465	COG0772	Belongs to the SEDS family
HG570_RS03470	COG1162	GTPase activity
HG570_RS03475	COG0564	pseudouridine synthase activity
HG570_RS03485	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HG570_RS03490	COG1136	(ABC) transporter
HG570_RS03510	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HG570_RS03540	COG2056	Na+-H+ antiporter family
HG570_RS03545	COG0534	Mate efflux family protein
HG570_RS03565	COG0552	protein localization to endoplasmic reticulum
HG570_RS03590	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HG570_RS03595	COG0746	molybdenum cofactor guanylyltransferase activity
HG570_RS03600	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG570_RS03610	COG0860	N-Acetylmuramoyl-L-alanine amidase
HG570_RS03620	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HG570_RS03625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HG570_RS03630	COG1758	RNA polymerase activity
HG570_RS03645	COG1049	propionate catabolic process, 2-methylcitrate cycle
HG570_RS03675	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HG570_RS03700	COG2217	Heavy metal translocating P-type atpase
HG570_RS03705	COG0606	chelatase, subunit chli
HG570_RS03735	COG0315	cyclic pyranopterin monophosphate synthase activity
HG570_RS03740	COG0521	Mo-molybdopterin cofactor biosynthetic process
HG570_RS03745	COG0314	molybdopterin synthase activity
HG570_RS03765	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG570_RS03765	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG570_RS03780	COG0736	holo-[acyl-carrier-protein] synthase activity
HG570_RS03785	COG1580	Controls the rotational direction of flagella during chemotaxis
HG570_RS03805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG570_RS03810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HG570_RS03815	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HG570_RS03820	COG1360	Flagellar Motor Protein
HG570_RS03830	COG1732	Glycine betaine
HG570_RS03835	COG1125	glycine betaine transport
HG570_RS03835	COG0517	IMP dehydrogenase activity
HG570_RS03855	COG0460	homoserine dehydrogenase
HG570_RS03865	COG3118	belongs to the thioredoxin family
HG570_RS03870	COG0492	ferredoxin-NADP+ reductase activity
HG570_RS03880	COG0724	RNA recognition motif
HG570_RS03890	COG0517	IMP dehydrogenase activity
HG570_RS03890	COG0516	GMP reductase activity
HG570_RS03900	COG0237	dephospho-CoA kinase activity
HG570_RS03920	COG0776	regulation of translation
HG570_RS03945	COG1086	Polysaccharide biosynthesis protein
HG570_RS03950	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HG570_RS03965	COG0351	phosphomethylpyrimidine kinase
HG570_RS03980	COG0732	type I restriction modification DNA specificity domain
HG570_RS03990	COG0671	phosphoesterase, PA-phosphatase related
HG570_RS04000	COG0488	(ABC) transporter
HG570_RS04020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG570_RS04025	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HG570_RS04035	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HG570_RS04070	COG0375	protein maturation
HG570_RS04075	COG1749	Flagellar hook protein flgE
HG570_RS04085	COG2824	Alkylphosphonate utilization operon protein PhnA
HG570_RS04100	COG0753	catalase activity
HG570_RS04135	COG0728	peptidoglycan biosynthetic process
HG570_RS04140	COG0215	cysteine-tRNA ligase activity
HG570_RS04150	COG1120	ATPase activity
HG570_RS04160	COG0300	oxidoreductase activity
HG570_RS04165	COG1607	acyl-coa hydrolase
HG570_RS04200	COG0409	Hydrogenase expression formation protein
HG570_RS04205	COG0298	carbon dioxide binding
HG570_RS04210	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HG570_RS04225	COG0280	phosphate acetyltransferase
HG570_RS04235	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HG570_RS04240	COG1749	Flagellar hook protein flgE
HG570_RS04240	COG1749	Flagellar hook protein flgE
HG570_RS04280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HG570_RS04285	COG0670	Belongs to the BI1 family
HG570_RS04290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG570_RS04305	COG1942	4-Oxalocrotonate Tautomerase
HG570_RS04330	COG0142	geranyltranstransferase activity
HG570_RS04345	COG0720	synthase
HG570_RS04350	COG0602	queuosine metabolic process
HG570_RS04375	COG0765	amino acid transport
HG570_RS04380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HG570_RS04390	COG1115	amino acid carrier protein
HG570_RS04395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG570_RS04400	COG0251	oxidation-reduction process
HG570_RS04430	COG1757	Na H antiporter
HG570_RS04450	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HG570_RS04460	COG1058	Belongs to the CinA family
HG570_RS04460	COG1546	Belongs to the CinA family
HG570_RS04480	COG0564	pseudouridine synthase activity
HG570_RS04485	COG1519	Transferase
HG570_RS04485	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HG570_RS04495	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HG570_RS04510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HG570_RS04525	COG3309	Virulence-associated protein D
HG570_RS04570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HG570_RS04580	COG0849	cell division
HG570_RS04585	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HG570_RS04600	COG0668	transmembrane transport
HG570_RS04695	COG1166	arginine decarboxylase activity
HG570_RS04720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG570_RS04720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG570_RS04725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HG570_RS04730	COG0668	transmembrane transport
HG570_RS04785	COG0537	adenosine 5'-monophosphoramidase activity
HG570_RS04795	COG0072	phenylalanine-tRNA ligase activity
HG570_RS04795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG570_RS04810	COG1185	polyribonucleotide nucleotidyltransferase activity
HG570_RS04810	COG0539	negative regulation of cytoplasmic translation
HG570_RS04820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HG570_RS04825	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HG570_RS04830	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HG570_RS04840	COG0835	chemotaxis
HG570_RS04840	COG0784	Response regulator, receiver
HG570_RS04845	COG2198	Histidine kinase
HG570_RS04845	COG0643	Histidine kinase
HG570_RS04845	COG0784	Response regulator, receiver
HG570_RS04850	COG0835	chemotaxis
HG570_RS04855	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HG570_RS04860	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HG570_RS04870	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HG570_RS04895	COG0501	Belongs to the peptidase M48B family
HG570_RS04900	COG2890	protein-(glutamine-N5) methyltransferase activity
HG570_RS04905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HG570_RS04915	COG1333	cytochrome c biogenesis protein
HG570_RS04915	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HG570_RS04935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HG570_RS04950	COG0511	ligase activity, forming carbon-carbon bonds
HG570_RS04955	COG0439	Biotin carboxylase
HG570_RS04975	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HG570_RS04985	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG570_RS04990	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HG570_RS05025	COG4221	oxidoreductase activity
HG570_RS05030	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HG570_RS05035	COG0800	Aldolase
HG570_RS05040	COG0129	dihydroxy-acid dehydratase activity
HG570_RS05045	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HG570_RS05050	COG0363	glucosamine-6-phosphate deaminase activity
HG570_RS05060	COG1064	alcohol dehydrogenase
HG570_RS05085	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HG570_RS05095	COG0674	pyruvate-flavodoxin oxidoreductase activity
HG570_RS05100	COG1013	pyruvate-flavodoxin oxidoreductase activity
HG570_RS05105	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HG570_RS05130	COG0405	Gamma-glutamyltransferase
HG570_RS05160	COG1047	Peptidyl-prolyl cis-trans
HG570_RS05170	COG2885	chlorophyll binding
HG570_RS05175	COG0823	Involved in the tonB-independent uptake of proteins
HG570_RS05185	COG0848	biopolymer transport protein
HG570_RS05190	COG0811	peptide transport
HG570_RS05200	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HG570_RS05230	COG1475	DNA binding
HG570_RS05235	COG1192	Involved in chromosome partitioning
HG570_RS05245	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HG570_RS05295	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HG570_RS05300	COG0525	valine-tRNA ligase activity
HG570_RS05325	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HG570_RS05350	COG3451	type IV secretory pathway VirB4
HG570_RS05360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HG570_RS05395	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HG570_RS05420	COG3041	Addiction module toxin RelE StbE family
HG570_RS05445	COG1192	Involved in chromosome partitioning
HG570_RS05480	COG4974	Belongs to the 'phage' integrase family
HG570_RS05485	COG2184	nucleotidyltransferase activity
HG570_RS05505	COG0716	FMN binding
HG570_RS05540	COG1966	Carbon starvation protein
HG570_RS05550	COG0765	amino acid transport
HG570_RS05555	COG1126	abc transporter atp-binding protein
HG570_RS05570	COG0738	Major facilitator superfamily
HG570_RS05575	COG2252	PERMEase
HG570_RS05595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HG570_RS05605	COG2814	Major facilitator Superfamily
HG570_RS05610	COG0037	tRNA processing
HG570_RS05615	COG0569	domain protein
HG570_RS05615	COG0475	glutathione-regulated potassium exporter activity
HG570_RS05625	COG2814	Major facilitator Superfamily
HG570_RS05640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HG570_RS05645	COG0124	histidyl-tRNA synthetase
HG570_RS05650	COG0859	PFAM glycosyl transferase family 9
HG570_RS05660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG570_RS05700	COG0250	Participates in transcription elongation, termination and antitermination
HG570_RS05745	COG1132	(ABC) transporter
HG570_RS05765	COG1045	serine acetyltransferase
HG570_RS05800	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HG570_RS05810	COG0151	Belongs to the GarS family
HG570_RS05815	COG1131	(ABC) transporter
HG570_RS05820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HG570_RS05845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG570_RS05850	COG2863	cytochrome
HG570_RS05860	COG0527	aspartate kinase activity
HG570_RS05875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HG570_RS05885	COG0697	spore germination
HG570_RS05900	COG0505	Belongs to the CarA family
HG570_RS05920	COG0424	maF-like protein
HG570_RS05945	COG0629	single-stranded DNA binding
HG570_RS05955	COG1466	dna polymerase III delta subunit
HG570_RS05960	COG0557	exoribonuclease II activity
HG570_RS05975	COG4174	ABC transporter (Permease)
HG570_RS05980	COG4166	transmembrane transport
HG570_RS05985	COG0180	Tryptophanyl-tRNA synthetase
HG570_RS05995	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HG570_RS06015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG570_RS06020	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG570_RS06030	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG570_RS06065	COG0839	Belongs to the complex I subunit 6 family
HG570_RS06075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HG570_RS06085	COG1007	ATP synthesis coupled electron transport
HG570_RS06095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG570_RS06110	COG0133	tryptophan synthase activity
HG570_RS06115	COG0135	phosphoribosylanthranilate isomerase activity
HG570_RS06115	COG0134	indole-3-glycerol-phosphate synthase activity
HG570_RS06120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HG570_RS06125	COG0512	Glutamine amidotransferase of anthranilate synthase
HG570_RS06130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG570_RS06135	COG0859	PFAM glycosyl transferase family 9
HG570_RS06145	COG2353	YceI-like domain
HG570_RS06170	COG0202	RNA polymerase activity
HG570_RS06195	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HG570_RS06200	COG0024	Methionine aminopeptidase
HG570_RS06205	COG0201	protein transport
HG570_RS06240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG570_RS06260	COG0255	Belongs to the universal ribosomal protein uL29 family
HG570_RS06300	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HG570_RS06330	COG0114	fumarate hydratase activity
HG570_RS06350	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HG570_RS06355	COG1687	branched-chain amino acid
HG570_RS06360	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HG570_RS06365	COG0484	heat shock protein binding
HG570_RS06395	COG0811	peptide transport
HG570_RS06400	COG0848	biopolymer transport protein
HG570_RS06405	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HG570_RS06415	COG0861	Integral membrane protein TerC family
HG570_RS06420	COG0598	Magnesium transport protein CorA
HG570_RS06425	COG0126	phosphoglycerate kinase activity
HG570_RS06430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG570_RS06440	COG0204	Acyl-transferase
HG570_RS06450	COG0793	Belongs to the peptidase S41A family
HG570_RS06475	COG0157	Belongs to the NadC ModD family
HG570_RS06480	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HG570_RS06500	COG0109	protoheme IX farnesyltransferase activity
HG570_RS06510	COG0305	Participates in initiation and elongation during chromosome replication
HG570_RS06515	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HG570_RS06515	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HG570_RS06520	COG0642	Histidine kinase
HG570_RS06525	COG0745	RESPONSE REGULATOR receiver
HG570_RS06530	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HG570_RS06545	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HG570_RS06560	COG1077	Cell shape determining protein MreB Mrl
HG570_RS06565	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HG570_RS06570	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG570_RS06575	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HG570_RS06590	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HG570_RS06595	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HG570_RS06600	COG0287	Prephenate dehydrogenase
HG570_RS06610	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HG570_RS06615	COG3421	Type III restriction
HG570_RS06655	COG1295	ribonuclease BN
HG570_RS06700	COG0799	negative regulation of ribosome biogenesis
HG570_RS06705	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HG570_RS06725	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HG570_RS06730	COG1987	bacterial-type flagellum assembly
HG570_RS06735	COG1157	protein secretion by the type III secretion system
HG570_RS06740	COG4962	Type ii secretion system protein e
HG570_RS06750	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HG570_RS06770	COG0517	IMP dehydrogenase activity
HG570_RS06770	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HG570_RS06775	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HG570_RS06795	COG0788	formyltetrahydrofolate deformylase activity
HG570_RS06840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG570_RS06860	COG0811	peptide transport
HG570_RS06865	COG0848	biopolymer transport protein
HG570_RS06885	COG0706	membrane insertase activity
HG570_RS06925	COG3118	belongs to the thioredoxin family
HG570_RS06930	COG1187	pseudouridine synthase activity
HG570_RS06935	COG0587	DNA-directed DNA polymerase activity
HG570_RS06960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HG570_RS06965	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HG570_RS06975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HG570_RS06985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG570_RS06985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG570_RS07015	COG0163	prenyltransferase activity
HG570_RS07050	COG2226	methyltransferase
HG570_RS07055	COG1981	membrane
HG570_RS07060	COG1739	Uncharacterized protein family UPF0029
HG570_RS07075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG570_RS07085	COG1253	flavin adenine dinucleotide binding
HG570_RS07090	COG0306	phosphate transporter
HG570_RS07095	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HG570_RS07105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HG570_RS07135	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HG570_RS07160	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HG570_RS07170	COG0786	glutamate:sodium symporter activity
HG570_RS07180	COG0348	domain, Protein
HG570_RS07185	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HG570_RS07205	COG1921	L-seryl-tRNASec selenium transferase activity
HG570_RS07210	COG0195	Participates in both transcription termination and antitermination
HG570_RS07235	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HG570_RS07250	COG0708	Exodeoxyribonuclease III
HG570_RS07280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HG570_RS07285	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HG570_RS07310	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HG570_RS07325	COG0010	Belongs to the arginase family
HG570_RS07330	COG0833	amino acid
HG570_RS07335	COG0686	Belongs to the AlaDH PNT family
HG570_RS07355	COG0497	DNA recombination
HG570_RS07380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HG570_RS07420	COG1074	ATP-dependent DNA helicase activity
HG570_RS07430	COG1862	Preprotein translocase
HG570_RS07435	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HG570_RS07440	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HG570_RS07450	COG0495	leucyl-tRNA aminoacylation
HG570_RS07460	COG0285	dihydrofolate synthase activity
HG570_RS07470	COG0739	heme binding
HG570_RS07480	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HG570_RS07510	COG0768	penicillin binding
HG570_RS07525	COG1558	bacterial-type flagellum-dependent cell motility
HG570_RS07530	COG1815	bacterial-type flagellum-dependent cell motility
HG570_RS07535	COG0772	Belongs to the SEDS family
HG570_RS07550	COG0450	alkyl hydroperoxide reductase
HG570_RS07560	COG0768	penicillin binding
HG570_RS07585	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HG570_RS07590	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HG570_RS07595	COG1388	LysM domain
HG570_RS07595	COG0741	lytic transglycosylase activity
HG570_RS07600	COG0084	hydrolase, TatD family'
HG570_RS07605	COG0307	riboflavin synthase, alpha
HG570_RS07615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HG570_RS07620	COG2011	ABC-type metal ion transport system permease component
HG570_RS07630	COG0671	phosphoesterase, PA-phosphatase related
HG570_RS07655	COG4786	Flagellar basal body rod
HG570_RS07670	COG4735	regulation of single-species biofilm formation