locus-tag	class	description
HPSH169_RS00020	COG0288	reversible hydration of carbon dioxide
HPSH169_RS00025	COG0288	reversible hydration of carbon dioxide
HPSH169_RS00075	COG0358	DNA primase activity
HPSH169_RS00080	COG0482	sulfurtransferase activity
HPSH169_RS00110	COG0835	chemotaxis
HPSH169_RS00110	COG0784	Response regulator, receiver
HPSH169_RS00120	COG0671	phosphoesterase, PA-phosphatase related
HPSH169_RS00125	COG2194	sulfuric ester hydrolase activity
HPSH169_RS00135	COG0372	Belongs to the citrate synthase family
HPSH169_RS00140	COG0538	isocitrate dehydrogenase activity
HPSH169_RS00160	COG0589	response to stress
HPSH169_RS00165	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPSH169_RS00220	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HPSH169_RS00235	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HPSH169_RS00240	COG2957	Belongs to the agmatine deiminase family
HPSH169_RS00275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPSH169_RS00280	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPSH169_RS00280	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPSH169_RS00280	COG0506	proline dehydrogenase activity
HPSH169_RS00320	COG0830	nickel cation binding
HPSH169_RS00360	COG0268	Binds directly to 16S ribosomal RNA
HPSH169_RS00365	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPSH169_RS00385	COG0840	transmembrane signaling receptor activity
HPSH169_RS00420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPSH169_RS00425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPSH169_RS00430	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPSH169_RS00465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPSH169_RS00475	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPSH169_RS00480	COG0840	transmembrane signaling receptor activity
HPSH169_RS00485	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPSH169_RS00495	COG1216	Glycosyl transferase, family 2
HPSH169_RS00505	COG0737	Belongs to the 5'-nucleotidase family
HPSH169_RS00515	COG0626	cystathionine gamma-synthase activity
HPSH169_RS00520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPSH169_RS00540	COG1420	regulation of RNA biosynthetic process
HPSH169_RS00560	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPSH169_RS00565	COG0551	DNA topoisomerase type I activity
HPSH169_RS00565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPSH169_RS00570	COG0731	radical SAM domain protein
HPSH169_RS00585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPSH169_RS00585	COG0574	Belongs to the PEP-utilizing enzyme family
HPSH169_RS00600	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HPSH169_RS00635	COG1760	l-serine dehydratase
HPSH169_RS00640	COG0814	amino acid
HPSH169_RS00645	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HPSH169_RS00655	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPSH169_RS00665	COG1139	Iron-sulfur cluster binding protein
HPSH169_RS00670	COG0247	lactate metabolic process
HPSH169_RS00675	COG1620	l-lactate permease
HPSH169_RS00680	COG1620	l-lactate permease
HPSH169_RS00685	COG1194	a g-specific adenine glycosylase
HPSH169_RS00690	COG0471	metal ion transport
HPSH169_RS00695	COG3278	Belongs to the heme-copper respiratory oxidase family
HPSH169_RS00775	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPSH169_RS00785	COG0113	porphobilinogen synthase activity
HPSH169_RS00790	COG0642	Histidine kinase
HPSH169_RS00795	COG0745	RESPONSE REGULATOR receiver
HPSH169_RS00810	COG0826	peptidase U32
HPSH169_RS00825	COG0303	'Molybdopterin
HPSH169_RS00840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPSH169_RS00845	COG0191	fructose-bisphosphate aldolase activity
HPSH169_RS00855	COG2089	acid synthase
HPSH169_RS00860	COG1136	(ABC) transporter
HPSH169_RS00865	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPSH169_RS00915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPSH169_RS00920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPSH169_RS00925	COG1053	succinate dehydrogenase
HPSH169_RS00940	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPSH169_RS00995	COG0489	protein tyrosine kinase activity
HPSH169_RS01040	COG3451	type IV secretory pathway VirB4
HPSH169_RS01045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPSH169_RS01080	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HPSH169_RS01105	COG3041	Addiction module toxin RelE StbE family
HPSH169_RS01130	COG1192	Involved in chromosome partitioning
HPSH169_RS01170	COG0582	viral genome integration into host DNA
HPSH169_RS01175	COG0326	Molecular chaperone. Has ATPase activity
HPSH169_RS01180	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPSH169_RS01195	COG0471	metal ion transport
HPSH169_RS01200	COG0575	Belongs to the CDS family
HPSH169_RS01220	COG1881	PFAM PEBP family protein
HPSH169_RS01230	COG1104	cysteine desulfurase activity
HPSH169_RS01245	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPSH169_RS01250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPSH169_RS01250	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPSH169_RS01255	COG0730	response to heat
HPSH169_RS01265	COG0659	secondary active sulfate transmembrane transporter activity
HPSH169_RS01295	COG0754	glutathionylspermidine amidase activity
HPSH169_RS01305	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPSH169_RS01345	COG0783	Belongs to the Dps family
HPSH169_RS01350	COG0642	Histidine kinase
HPSH169_RS01355	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPSH169_RS01380	COG4172	Belongs to the ABC transporter superfamily
HPSH169_RS01385	COG4239	(ABC) transporter, permease
HPSH169_RS01420	COG0750	zinc metalloprotease
HPSH169_RS01460	COG0542	response to heat
HPSH169_RS01465	COG0785	Cytochrome C biogenesis protein
HPSH169_RS01470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPSH169_RS01475	COG0402	S-adenosylhomocysteine deaminase activity
HPSH169_RS01510	COG0727	PFAM Uncharacterised protein family (UPF0153)
HPSH169_RS01520	COG0134	indole-3-glycerol-phosphate synthase activity
HPSH169_RS01530	COG0248	Ppx GppA phosphatase
HPSH169_RS01535	COG0859	PFAM glycosyl transferase family 9
HPSH169_RS01565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPSH169_RS01570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPSH169_RS01590	COG0019	diaminopimelate decarboxylase activity
HPSH169_RS01605	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPSH169_RS01630	COG0747	negative chemotaxis
HPSH169_RS01635	COG0601	transmembrane transport
HPSH169_RS01640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPSH169_RS01645	COG0444	Belongs to the ABC transporter superfamily
HPSH169_RS01650	COG4608	Belongs to the ABC transporter superfamily
HPSH169_RS01685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPSH169_RS01690	COG0726	polysaccharide deacetylase
HPSH169_RS01710	COG0523	cobalamin synthesis protein
HPSH169_RS01720	COG0748	coenzyme F420 binding
HPSH169_RS01755	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPSH169_RS01760	COG3980	spore coat polysaccharide biosynthesis protein
HPSH169_RS01765	COG3980	spore coat polysaccharide biosynthesis protein
HPSH169_RS01770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPSH169_RS01775	COG1663	tetraacyldisaccharide 4'-kinase activity
HPSH169_RS01795	COG2894	cell division
HPSH169_RS01805	COG0758	DNA mediated transformation
HPSH169_RS01805	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPSH169_RS01855	COG0564	pseudouridine synthase activity
HPSH169_RS01860	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPSH169_RS01860	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HPSH169_RS01865	COG0504	CTP synthase activity
HPSH169_RS01875	COG1766	The M ring may be actively involved in energy transduction
HPSH169_RS01880	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPSH169_RS01890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPSH169_RS01915	COG4786	Flagellar basal body rod
HPSH169_RS01920	COG0477	Major facilitator Superfamily
HPSH169_RS01925	COG1674	ftsk spoiiie
HPSH169_RS01935	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPSH169_RS01940	COG0196	riboflavin kinase activity
HPSH169_RS01945	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPSH169_RS01965	COG1132	(ABC) transporter
HPSH169_RS01980	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HPSH169_RS02000	COG2608	mercury ion transmembrane transporter activity
HPSH169_RS02005	COG2217	Heavy metal translocating P-type atpase
HPSH169_RS02010	COG1183	phosphatidylcholine synthase activity
HPSH169_RS02020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPSH169_RS02030	COG0745	RESPONSE REGULATOR receiver
HPSH169_RS02055	COG0357	Ribosomal RNA small subunit methyltransferase G
HPSH169_RS02065	COG0805	protein transport
HPSH169_RS02110	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPSH169_RS02120	COG0083	homoserine kinase activity
HPSH169_RS02150	COG1408	metallophosphoesterase
HPSH169_RS02160	COG0745	RESPONSE REGULATOR receiver
HPSH169_RS02165	COG2404	hydrolase activity, acting on ester bonds
HPSH169_RS02170	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPSH169_RS02190	COG0006	proline dipeptidase activity
HPSH169_RS02195	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPSH169_RS02200	COG1419	protein localization to endoplasmic reticulum
HPSH169_RS02205	COG0455	bacterial-type flagellum organization
HPSH169_RS02220	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPSH169_RS02225	COG1776	CheC inhibitor of MCP methylation
HPSH169_RS02225	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPSH169_RS02240	COG0735	belongs to the Fur family
HPSH169_RS02245	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPSH169_RS02245	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HPSH169_RS02250	COG0789	Transcriptional regulator
HPSH169_RS02255	COG0484	heat shock protein binding
HPSH169_RS02270	COG0745	RESPONSE REGULATOR receiver
HPSH169_RS02285	COG0833	amino acid
HPSH169_RS02290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPSH169_RS02300	COG1028	Short-chain dehydrogenase reductase Sdr
HPSH169_RS02320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPSH169_RS02420	COG1217	gtp-binding protein TYPA
HPSH169_RS02490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPSH169_RS02500	COG0824	Thioesterase
HPSH169_RS02505	COG0733	neurotransmitter:sodium symporter activity
HPSH169_RS02510	COG0733	neurotransmitter:sodium symporter activity
HPSH169_RS02520	COG0592	DNA-directed DNA polymerase activity
HPSH169_RS02525	COG0187	DNA topoisomerase II activity
HPSH169_RS02535	COG0739	heme binding
HPSH169_RS02535	COG1196	nuclear chromosome segregation
HPSH169_RS02535	COG0741	lytic transglycosylase activity
HPSH169_RS02550	COG0277	FAD linked oxidase domain protein
HPSH169_RS02560	COG0174	glutamine synthetase
HPSH169_RS02720	COG3451	type IV secretory pathway VirB4
HPSH169_RS02740	COG1842	Phage shock protein A
HPSH169_RS02755	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPSH169_RS02765	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPSH169_RS02770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPSH169_RS02795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPSH169_RS02840	COG0628	permease
HPSH169_RS02850	COG0012	GTP binding
HPSH169_RS02860	COG0586	Pfam SNARE associated Golgi protein
HPSH169_RS02875	COG0698	ribose 5-phosphate isomerase
HPSH169_RS02880	COG1994	Peptidase M50
HPSH169_RS02885	COG0681	Belongs to the peptidase S26 family
HPSH169_RS02925	COG1776	CheC inhibitor of MCP methylation
HPSH169_RS02925	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPSH169_RS02930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPSH169_RS02935	COG1918	ferrous iron import across plasma membrane
HPSH169_RS02955	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPSH169_RS02955	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPSH169_RS02960	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPSH169_RS02990	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPSH169_RS02995	COG0156	8-amino-7-oxononanoate synthase activity
HPSH169_RS03000	COG0840	transmembrane signaling receptor activity
HPSH169_RS03010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPSH169_RS03060	COG1131	(ABC) transporter
HPSH169_RS03075	COG0784	Response regulator, receiver
HPSH169_RS03075	COG0835	chemotaxis
HPSH169_RS03090	COG3306	glycosyltransferase involved in LPS biosynthesis
HPSH169_RS03100	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPSH169_RS03105	COG1193	negative regulation of DNA recombination
HPSH169_RS03120	COG0436	Aminotransferase
HPSH169_RS03130	COG2171	N-acyltransferase activity
HPSH169_RS03145	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPSH169_RS03150	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HPSH169_RS03155	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HPSH169_RS03160	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HPSH169_RS03165	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HPSH169_RS03170	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HPSH169_RS03195	COG0617	tRNA 3'-terminal CCA addition
HPSH169_RS03200	COG0778	Nitroreductase
HPSH169_RS03210	COG0762	integral membrane protein
HPSH169_RS03235	COG1027	Aspartate ammonia-lyase
HPSH169_RS03255	COG0560	Phosphoserine phosphatase
HPSH169_RS03260	COG1528	Iron-storage protein
HPSH169_RS03265	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HPSH169_RS03270	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPSH169_RS03275	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HPSH169_RS03285	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPSH169_RS03300	COG0328	RNA-DNA hybrid ribonuclease activity
HPSH169_RS03305	COG0571	ribonuclease III activity
HPSH169_RS03320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPSH169_RS03355	COG4974	Belongs to the 'phage' integrase family
HPSH169_RS03365	COG0730	response to heat
HPSH169_RS03375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPSH169_RS03390	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPSH169_RS03395	COG1338	Plays a role in the flagellum-specific transport system
HPSH169_RS03420	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HPSH169_RS03445	COG0183	Belongs to the thiolase family
HPSH169_RS03450	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPSH169_RS03455	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPSH169_RS03460	COG2031	fatty acid transporter
HPSH169_RS03470	COG0145	ligase activity
HPSH169_RS03475	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HPSH169_RS03480	COG4647	ligase activity
HPSH169_RS03495	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPSH169_RS03500	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPSH169_RS03510	COG2204	response regulator
HPSH169_RS03520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPSH169_RS03540	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HPSH169_RS03555	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPSH169_RS03560	COG1137	ATPase activity
HPSH169_RS03570	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPSH169_RS03590	COG0252	asparaginase activity
HPSH169_RS03595	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPSH169_RS03610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPSH169_RS03615	COG0037	tRNA processing
HPSH169_RS03645	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPSH169_RS03650	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPSH169_RS03655	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPSH169_RS03670	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPSH169_RS03680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPSH169_RS03700	COG0564	pseudouridine synthase activity
HPSH169_RS03710	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPSH169_RS03715	COG1136	(ABC) transporter
HPSH169_RS03735	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPSH169_RS03750	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPSH169_RS03765	COG2056	Na+-H+ antiporter family
HPSH169_RS03770	COG0534	Mate efflux family protein
HPSH169_RS03790	COG0552	protein localization to endoplasmic reticulum
HPSH169_RS03810	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPSH169_RS03820	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPSH169_RS03830	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPSH169_RS03840	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPSH169_RS03845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPSH169_RS03865	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPSH169_RS03895	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPSH169_RS03925	COG2217	Heavy metal translocating P-type atpase
HPSH169_RS03930	COG0606	chelatase, subunit chli
HPSH169_RS03975	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPSH169_RS03980	COG0314	molybdopterin synthase activity
HPSH169_RS04000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPSH169_RS04000	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPSH169_RS04015	COG0736	holo-[acyl-carrier-protein] synthase activity
HPSH169_RS04020	COG1580	Controls the rotational direction of flagella during chemotaxis
HPSH169_RS04040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPSH169_RS04045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPSH169_RS04050	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPSH169_RS04055	COG1360	Flagellar Motor Protein
HPSH169_RS04065	COG1732	Glycine betaine
HPSH169_RS04070	COG0517	IMP dehydrogenase activity
HPSH169_RS04070	COG1125	glycine betaine transport
HPSH169_RS04090	COG0460	homoserine dehydrogenase
HPSH169_RS04100	COG3118	belongs to the thioredoxin family
HPSH169_RS04105	COG0492	ferredoxin-NADP+ reductase activity
HPSH169_RS04115	COG0724	RNA recognition motif
HPSH169_RS04125	COG0516	GMP reductase activity
HPSH169_RS04125	COG0517	IMP dehydrogenase activity
HPSH169_RS04135	COG0237	dephospho-CoA kinase activity
HPSH169_RS04155	COG0776	regulation of translation
HPSH169_RS04180	COG1086	Polysaccharide biosynthesis protein
HPSH169_RS04185	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPSH169_RS04205	COG1083	cytidylyl-transferase
HPSH169_RS04215	COG2089	acid synthase
HPSH169_RS04245	COG0671	phosphoesterase, PA-phosphatase related
HPSH169_RS04255	COG0488	(ABC) transporter
HPSH169_RS04275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPSH169_RS04280	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPSH169_RS04290	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HPSH169_RS04325	COG0375	protein maturation
HPSH169_RS04330	COG1749	Flagellar hook protein flgE
HPSH169_RS04335	COG2134	cdp-diacylglycerol pyrophosphatase
HPSH169_RS04340	COG2824	Alkylphosphonate utilization operon protein PhnA
HPSH169_RS04355	COG0753	catalase activity
HPSH169_RS04390	COG0728	peptidoglycan biosynthetic process
HPSH169_RS04405	COG1120	ATPase activity
HPSH169_RS04410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPSH169_RS04415	COG0300	oxidoreductase activity
HPSH169_RS04420	COG1607	acyl-coa hydrolase
HPSH169_RS04455	COG0409	Hydrogenase expression formation protein
HPSH169_RS04460	COG0298	carbon dioxide binding
HPSH169_RS04465	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HPSH169_RS04480	COG0280	phosphate acetyltransferase
HPSH169_RS04490	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HPSH169_RS04495	COG1749	Flagellar hook protein flgE
HPSH169_RS04495	COG1749	Flagellar hook protein flgE
HPSH169_RS04540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPSH169_RS04545	COG0670	Belongs to the BI1 family
HPSH169_RS04550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPSH169_RS04565	COG1942	4-Oxalocrotonate Tautomerase
HPSH169_RS04590	COG0142	geranyltranstransferase activity
HPSH169_RS04605	COG0720	synthase
HPSH169_RS04610	COG0602	queuosine metabolic process
HPSH169_RS04620	COG1842	Phage shock protein A
HPSH169_RS04650	COG0765	amino acid transport
HPSH169_RS04655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPSH169_RS04665	COG1115	amino acid carrier protein
HPSH169_RS04670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPSH169_RS04675	COG0251	oxidation-reduction process
HPSH169_RS04705	COG1757	Na H antiporter
HPSH169_RS04725	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPSH169_RS04735	COG1058	Belongs to the CinA family
HPSH169_RS04735	COG1546	Belongs to the CinA family
HPSH169_RS04755	COG0564	pseudouridine synthase activity
HPSH169_RS04760	COG1519	Transferase
HPSH169_RS04760	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPSH169_RS04770	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPSH169_RS04810	COG3309	Virulence-associated protein D
HPSH169_RS04845	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPSH169_RS04855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPSH169_RS04865	COG0849	cell division
HPSH169_RS04870	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPSH169_RS04885	COG0668	transmembrane transport
HPSH169_RS04895	COG1570	exodeoxyribonuclease VII activity
HPSH169_RS04975	COG1166	arginine decarboxylase activity
HPSH169_RS05000	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPSH169_RS05000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPSH169_RS05005	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPSH169_RS05010	COG0668	transmembrane transport
HPSH169_RS05065	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPSH169_RS05070	COG0537	adenosine 5'-monophosphoramidase activity
HPSH169_RS05080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPSH169_RS05080	COG0072	phenylalanine-tRNA ligase activity
HPSH169_RS05095	COG0539	negative regulation of cytoplasmic translation
HPSH169_RS05095	COG1185	polyribonucleotide nucleotidyltransferase activity
HPSH169_RS05105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPSH169_RS05110	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPSH169_RS05115	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPSH169_RS05125	COG0835	chemotaxis
HPSH169_RS05125	COG0784	Response regulator, receiver
HPSH169_RS05130	COG0784	Response regulator, receiver
HPSH169_RS05130	COG2198	Histidine kinase
HPSH169_RS05130	COG0643	Histidine kinase
HPSH169_RS05135	COG0835	chemotaxis
HPSH169_RS05140	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HPSH169_RS05145	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPSH169_RS05155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPSH169_RS05180	COG0501	Belongs to the peptidase M48B family
HPSH169_RS05185	COG2890	protein-(glutamine-N5) methyltransferase activity
HPSH169_RS05190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPSH169_RS05200	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPSH169_RS05200	COG1333	cytochrome c biogenesis protein
HPSH169_RS05220	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPSH169_RS05235	COG0511	ligase activity, forming carbon-carbon bonds
HPSH169_RS05240	COG0439	Biotin carboxylase
HPSH169_RS05260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPSH169_RS05270	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPSH169_RS05275	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPSH169_RS05310	COG4221	oxidoreductase activity
HPSH169_RS05315	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPSH169_RS05320	COG0800	Aldolase
HPSH169_RS05325	COG0129	dihydroxy-acid dehydratase activity
HPSH169_RS05330	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPSH169_RS05335	COG0363	glucosamine-6-phosphate deaminase activity
HPSH169_RS05345	COG1064	alcohol dehydrogenase
HPSH169_RS05370	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPSH169_RS05380	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPSH169_RS05385	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPSH169_RS05390	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPSH169_RS05415	COG0405	Gamma-glutamyltransferase
HPSH169_RS05445	COG1047	Peptidyl-prolyl cis-trans
HPSH169_RS05455	COG2885	chlorophyll binding
HPSH169_RS05460	COG0823	Involved in the tonB-independent uptake of proteins
HPSH169_RS05470	COG0848	biopolymer transport protein
HPSH169_RS05475	COG0811	peptide transport
HPSH169_RS05485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPSH169_RS05515	COG1475	DNA binding
HPSH169_RS05520	COG1192	Involved in chromosome partitioning
HPSH169_RS05530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPSH169_RS05585	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPSH169_RS05590	COG0525	valine-tRNA ligase activity
HPSH169_RS05615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPSH169_RS05620	COG2184	nucleotidyltransferase activity
HPSH169_RS05630	COG0716	FMN binding
HPSH169_RS05645	COG0492	ferredoxin-NADP+ reductase activity
HPSH169_RS05670	COG0166	Belongs to the GPI family
HPSH169_RS05680	COG1966	Carbon starvation protein
HPSH169_RS05690	COG0765	amino acid transport
HPSH169_RS05695	COG1126	abc transporter atp-binding protein
HPSH169_RS05710	COG0738	Major facilitator superfamily
HPSH169_RS05715	COG2252	PERMEase
HPSH169_RS05735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPSH169_RS05745	COG2814	Major facilitator Superfamily
HPSH169_RS05750	COG0037	tRNA processing
HPSH169_RS05755	COG0569	domain protein
HPSH169_RS05755	COG0475	glutathione-regulated potassium exporter activity
HPSH169_RS05760	COG0534	Mate efflux family protein
HPSH169_RS05765	COG2814	Major facilitator Superfamily
HPSH169_RS05780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPSH169_RS05790	COG0859	PFAM glycosyl transferase family 9
HPSH169_RS05850	COG0250	Participates in transcription elongation, termination and antitermination
HPSH169_RS05895	COG1132	(ABC) transporter
HPSH169_RS05910	COG1045	serine acetyltransferase
HPSH169_RS05940	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPSH169_RS05950	COG0151	Belongs to the GarS family
HPSH169_RS05960	COG1131	(ABC) transporter
HPSH169_RS05965	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPSH169_RS05990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPSH169_RS05995	COG2863	cytochrome
HPSH169_RS06005	COG0527	aspartate kinase activity
HPSH169_RS06020	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPSH169_RS06030	COG0697	spore germination
HPSH169_RS06045	COG0505	Belongs to the CarA family
HPSH169_RS06090	COG0629	single-stranded DNA binding
HPSH169_RS06100	COG1466	dna polymerase III delta subunit
HPSH169_RS06105	COG0557	exoribonuclease II activity
HPSH169_RS06120	COG4174	ABC transporter (Permease)
HPSH169_RS06125	COG4166	transmembrane transport
HPSH169_RS06130	COG0180	Tryptophanyl-tRNA synthetase
HPSH169_RS06140	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPSH169_RS06160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPSH169_RS06165	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPSH169_RS06175	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPSH169_RS06210	COG0839	Belongs to the complex I subunit 6 family
HPSH169_RS06220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPSH169_RS06230	COG1007	ATP synthesis coupled electron transport
HPSH169_RS06255	COG0133	tryptophan synthase activity
HPSH169_RS06260	COG0135	phosphoribosylanthranilate isomerase activity
HPSH169_RS06260	COG0134	indole-3-glycerol-phosphate synthase activity
HPSH169_RS06270	COG0512	Glutamine amidotransferase of anthranilate synthase
HPSH169_RS06275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPSH169_RS06280	COG0859	PFAM glycosyl transferase family 9
HPSH169_RS06290	COG2353	YceI-like domain
HPSH169_RS06295	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HPSH169_RS06315	COG0202	RNA polymerase activity
HPSH169_RS06340	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPSH169_RS06345	COG0024	Methionine aminopeptidase
HPSH169_RS06350	COG0201	protein transport
HPSH169_RS06385	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPSH169_RS06405	COG0255	Belongs to the universal ribosomal protein uL29 family
HPSH169_RS06445	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPSH169_RS06475	COG0114	fumarate hydratase activity
HPSH169_RS06495	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPSH169_RS06500	COG1687	branched-chain amino acid
HPSH169_RS06505	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HPSH169_RS06510	COG0484	heat shock protein binding
HPSH169_RS06530	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPSH169_RS06540	COG0811	peptide transport
HPSH169_RS06545	COG0848	biopolymer transport protein
HPSH169_RS06550	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPSH169_RS06560	COG0861	Integral membrane protein TerC family
HPSH169_RS06565	COG0598	Magnesium transport protein CorA
HPSH169_RS06570	COG0126	phosphoglycerate kinase activity
HPSH169_RS06575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPSH169_RS06585	COG0204	Acyl-transferase
HPSH169_RS06595	COG0793	Belongs to the peptidase S41A family
HPSH169_RS06630	COG0157	Belongs to the NadC ModD family
HPSH169_RS06635	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPSH169_RS06655	COG0109	protoheme IX farnesyltransferase activity
HPSH169_RS06665	COG0305	Participates in initiation and elongation during chromosome replication
HPSH169_RS06670	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPSH169_RS06670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPSH169_RS06675	COG0642	Histidine kinase
HPSH169_RS06680	COG0745	RESPONSE REGULATOR receiver
HPSH169_RS06715	COG1077	Cell shape determining protein MreB Mrl
HPSH169_RS06720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPSH169_RS06745	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPSH169_RS06750	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPSH169_RS06755	COG0287	Prephenate dehydrogenase
HPSH169_RS06770	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HPSH169_RS06785	COG1295	ribonuclease BN
HPSH169_RS06820	COG0799	negative regulation of ribosome biogenesis
HPSH169_RS06845	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPSH169_RS06850	COG1987	bacterial-type flagellum assembly
HPSH169_RS06855	COG1157	protein secretion by the type III secretion system
HPSH169_RS06860	COG4962	Type ii secretion system protein e
HPSH169_RS06870	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPSH169_RS06890	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPSH169_RS06890	COG0517	IMP dehydrogenase activity
HPSH169_RS06895	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPSH169_RS06910	COG0732	type I restriction modification DNA specificity domain
HPSH169_RS06915	COG0788	formyltetrahydrofolate deformylase activity
HPSH169_RS06965	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPSH169_RS06985	COG0811	peptide transport
HPSH169_RS06990	COG0848	biopolymer transport protein
HPSH169_RS07010	COG0706	membrane insertase activity
HPSH169_RS07050	COG3118	belongs to the thioredoxin family
HPSH169_RS07055	COG1187	pseudouridine synthase activity
HPSH169_RS07060	COG0587	DNA-directed DNA polymerase activity
HPSH169_RS07085	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPSH169_RS07090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPSH169_RS07100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPSH169_RS07110	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPSH169_RS07110	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPSH169_RS07145	COG0163	prenyltransferase activity
HPSH169_RS07180	COG2226	methyltransferase
HPSH169_RS07185	COG1981	membrane
HPSH169_RS07190	COG1739	Uncharacterized protein family UPF0029
HPSH169_RS07205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPSH169_RS07215	COG1253	flavin adenine dinucleotide binding
HPSH169_RS07220	COG0306	phosphate transporter
HPSH169_RS07225	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HPSH169_RS07235	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPSH169_RS07275	COG2217	Heavy metal translocating P-type atpase
HPSH169_RS07280	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HPSH169_RS07290	COG0786	glutamate:sodium symporter activity
HPSH169_RS07300	COG0348	domain, Protein
HPSH169_RS07305	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPSH169_RS07325	COG1921	L-seryl-tRNASec selenium transferase activity
HPSH169_RS07330	COG0195	Participates in both transcription termination and antitermination
HPSH169_RS07355	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPSH169_RS07370	COG0708	Exodeoxyribonuclease III
HPSH169_RS07405	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPSH169_RS07410	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HPSH169_RS07430	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HPSH169_RS07445	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HPSH169_RS07455	COG4772	TonB-dependent receptor
HPSH169_RS07460	COG0010	Belongs to the arginase family
HPSH169_RS07465	COG0686	Belongs to the AlaDH PNT family
HPSH169_RS07485	COG0497	DNA recombination
HPSH169_RS07525	COG2176	DNA-directed DNA polymerase activity
HPSH169_RS07530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPSH169_RS07570	COG1074	ATP-dependent DNA helicase activity
HPSH169_RS07580	COG1862	Preprotein translocase
HPSH169_RS07585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPSH169_RS07590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPSH169_RS07600	COG0495	leucyl-tRNA aminoacylation
HPSH169_RS07610	COG0285	dihydrofolate synthase activity
HPSH169_RS07620	COG0739	heme binding
HPSH169_RS07630	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPSH169_RS07635	COG0723	plastoquinol--plastocyanin reductase activity
HPSH169_RS07655	COG0768	penicillin binding
HPSH169_RS07665	COG1558	bacterial-type flagellum-dependent cell motility
HPSH169_RS07670	COG1815	bacterial-type flagellum-dependent cell motility
HPSH169_RS07675	COG0772	Belongs to the SEDS family
HPSH169_RS07690	COG0450	alkyl hydroperoxide reductase
HPSH169_RS07700	COG0768	penicillin binding
HPSH169_RS07725	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HPSH169_RS07730	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPSH169_RS07735	COG1388	LysM domain
HPSH169_RS07735	COG0741	lytic transglycosylase activity
HPSH169_RS07740	COG0084	hydrolase, TatD family'
HPSH169_RS07745	COG0307	riboflavin synthase, alpha
HPSH169_RS07760	COG2011	ABC-type metal ion transport system permease component
HPSH169_RS07770	COG0671	phosphoesterase, PA-phosphatase related
HPSH169_RS07775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPSH169_RS07795	COG4786	Flagellar basal body rod
HPSH169_RS07805	COG4735	regulation of single-species biofilm formation