locus-tag	class	description
HPSA_RS00005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPSA_RS00010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPSA_RS00015	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPSA_RS00020	COG0288	reversible hydration of carbon dioxide
HPSA_RS00070	COG0459	protein refolding
HPSA_RS00080	COG0358	DNA primase activity
HPSA_RS00085	COG0482	sulfurtransferase activity
HPSA_RS00115	COG0784	Response regulator, receiver
HPSA_RS00115	COG0835	chemotaxis
HPSA_RS00125	COG0671	phosphoesterase, PA-phosphatase related
HPSA_RS00130	COG2194	sulfuric ester hydrolase activity
HPSA_RS00145	COG0372	Belongs to the citrate synthase family
HPSA_RS00150	COG0538	isocitrate dehydrogenase activity
HPSA_RS00160	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPSA_RS00170	COG0589	response to stress
HPSA_RS00175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPSA_RS00185	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HPSA_RS00190	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPSA_RS00230	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HPSA_RS00250	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HPSA_RS00275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPSA_RS00280	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPSA_RS00280	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPSA_RS00280	COG0506	proline dehydrogenase activity
HPSA_RS00355	COG0829	nickel cation binding
HPSA_RS00365	COG0830	nickel cation binding
HPSA_RS00370	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HPSA_RS00385	COG0832	Belongs to the urease beta subunit family
HPSA_RS00385	COG0831	urea catabolic process
HPSA_RS00395	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPSA_RS00400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPSA_RS00405	COG0268	Binds directly to 16S ribosomal RNA
HPSA_RS00410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPSA_RS00430	COG0840	transmembrane signaling receptor activity
HPSA_RS00450	COG0579	oxidoreductase
HPSA_RS00460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPSA_RS00465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPSA_RS00470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPSA_RS00505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPSA_RS00515	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPSA_RS00520	COG0840	transmembrane signaling receptor activity
HPSA_RS00525	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPSA_RS00535	COG1216	Glycosyl transferase, family 2
HPSA_RS00540	COG0840	transmembrane signaling receptor activity
HPSA_RS00550	COG0626	cystathionine gamma-synthase activity
HPSA_RS00555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPSA_RS00565	COG0443	Heat shock 70 kDa protein
HPSA_RS00570	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPSA_RS00575	COG1420	regulation of RNA biosynthetic process
HPSA_RS00595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPSA_RS00600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPSA_RS00600	COG0551	DNA topoisomerase type I activity
HPSA_RS00605	COG0731	radical SAM domain protein
HPSA_RS00615	COG0574	Belongs to the PEP-utilizing enzyme family
HPSA_RS00615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPSA_RS00625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPSA_RS00630	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HPSA_RS00640	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPSA_RS00660	COG1760	l-serine dehydratase
HPSA_RS00665	COG0814	amino acid
HPSA_RS00670	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HPSA_RS00680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPSA_RS00690	COG1139	Iron-sulfur cluster binding protein
HPSA_RS00695	COG0247	lactate metabolic process
HPSA_RS00700	COG1620	l-lactate permease
HPSA_RS00705	COG1620	l-lactate permease
HPSA_RS00710	COG1194	a g-specific adenine glycosylase
HPSA_RS00715	COG0471	metal ion transport
HPSA_RS00720	COG3278	Belongs to the heme-copper respiratory oxidase family
HPSA_RS00765	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPSA_RS00770	COG0148	phosphopyruvate hydratase activity
HPSA_RS00800	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPSA_RS00810	COG0217	transcriptional regulatory protein
HPSA_RS00815	COG0113	porphobilinogen synthase activity
HPSA_RS00820	COG0642	Histidine kinase
HPSA_RS00825	COG0745	RESPONSE REGULATOR receiver
HPSA_RS00840	COG0826	peptidase U32
HPSA_RS00855	COG0303	'Molybdopterin
HPSA_RS00875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPSA_RS00880	COG0191	fructose-bisphosphate aldolase activity
HPSA_RS00890	COG2089	acid synthase
HPSA_RS00895	COG1136	(ABC) transporter
HPSA_RS00900	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPSA_RS00915	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPSA_RS00940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPSA_RS00945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPSA_RS00950	COG1053	succinate dehydrogenase
HPSA_RS00960	COG0149	triose-phosphate isomerase activity
HPSA_RS00965	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPSA_RS00970	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPSA_RS00980	COG0105	UTP biosynthetic process
HPSA_RS00995	COG0416	fatty acid biosynthetic process
HPSA_RS01000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPSA_RS01020	COG0489	protein tyrosine kinase activity
HPSA_RS01040	COG0326	Molecular chaperone. Has ATPase activity
HPSA_RS01045	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPSA_RS01050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPSA_RS01055	COG0445	tRNA wobble uridine modification
HPSA_RS01060	COG0471	metal ion transport
HPSA_RS01065	COG0575	Belongs to the CDS family
HPSA_RS01085	COG1881	PFAM PEBP family protein
HPSA_RS01110	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPSA_RS01115	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPSA_RS01115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPSA_RS01120	COG0730	response to heat
HPSA_RS01130	COG0659	secondary active sulfate transmembrane transporter activity
HPSA_RS01145	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPSA_RS01160	COG0754	glutathionylspermidine amidase activity
HPSA_RS01170	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPSA_RS01180	COG0181	hydroxymethylbilane synthase activity
HPSA_RS01185	COG0442	prolyl-tRNA aminoacylation
HPSA_RS01210	COG0783	Belongs to the Dps family
HPSA_RS01215	COG0642	Histidine kinase
HPSA_RS01220	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPSA_RS01225	COG1706	bacterial-type flagellum-dependent cell motility
HPSA_RS01245	COG4172	Belongs to the ABC transporter superfamily
HPSA_RS01250	COG4239	(ABC) transporter, permease
HPSA_RS01270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPSA_RS01285	COG0750	zinc metalloprotease
HPSA_RS01290	COG1570	exodeoxyribonuclease VII activity
HPSA_RS01315	COG0542	response to heat
HPSA_RS01320	COG0785	Cytochrome C biogenesis protein
HPSA_RS01325	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPSA_RS01330	COG0402	S-adenosylhomocysteine deaminase activity
HPSA_RS01340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPSA_RS01365	COG0727	PFAM Uncharacterised protein family (UPF0153)
HPSA_RS01380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPSA_RS01385	COG0248	Ppx GppA phosphatase
HPSA_RS01390	COG0859	PFAM glycosyl transferase family 9
HPSA_RS01400	COG0343	queuine tRNA-ribosyltransferase activity
HPSA_RS01420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPSA_RS01425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPSA_RS01445	COG0019	diaminopimelate decarboxylase activity
HPSA_RS01460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPSA_RS01465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPSA_RS01475	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPSA_RS01485	COG0747	negative chemotaxis
HPSA_RS01490	COG0601	transmembrane transport
HPSA_RS01495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPSA_RS01500	COG0444	Belongs to the ABC transporter superfamily
HPSA_RS01505	COG4608	Belongs to the ABC transporter superfamily
HPSA_RS01540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPSA_RS01545	COG0726	polysaccharide deacetylase
HPSA_RS01555	COG0523	cobalamin synthesis protein
HPSA_RS01570	COG0748	coenzyme F420 binding
HPSA_RS01575	COG0018	arginyl-trna synthetase
HPSA_RS01580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPSA_RS01605	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPSA_RS01610	COG3980	spore coat polysaccharide biosynthesis protein
HPSA_RS01615	COG3980	spore coat polysaccharide biosynthesis protein
HPSA_RS01620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPSA_RS01625	COG1663	tetraacyldisaccharide 4'-kinase activity
HPSA_RS01630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPSA_RS01640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPSA_RS01645	COG2894	cell division
HPSA_RS01650	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPSA_RS01655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPSA_RS01655	COG0758	DNA mediated transformation
HPSA_RS01680	COG0564	pseudouridine synthase activity
HPSA_RS01685	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HPSA_RS01685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPSA_RS01690	COG0504	CTP synthase activity
HPSA_RS01700	COG1766	The M ring may be actively involved in energy transduction
HPSA_RS01705	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPSA_RS01715	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPSA_RS01740	COG4786	Flagellar basal body rod
HPSA_RS01745	COG0477	Major facilitator Superfamily
HPSA_RS01750	COG0737	Belongs to the 5'-nucleotidase family
HPSA_RS01755	COG1674	ftsk spoiiie
HPSA_RS01765	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPSA_RS01770	COG0196	riboflavin kinase activity
HPSA_RS01775	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HPSA_RS01785	COG0540	Belongs to the ATCase OTCase family
HPSA_RS01795	COG1132	(ABC) transporter
HPSA_RS01820	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HPSA_RS01840	COG2608	mercury ion transmembrane transporter activity
HPSA_RS01850	COG1183	phosphatidylcholine synthase activity
HPSA_RS01860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPSA_RS01865	COG2264	protein methyltransferase activity
HPSA_RS01870	COG0745	RESPONSE REGULATOR receiver
HPSA_RS01895	COG0357	Ribosomal RNA small subunit methyltransferase G
HPSA_RS01900	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPSA_RS01905	COG0805	protein transport
HPSA_RS01910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPSA_RS01915	COG2255	four-way junction helicase activity
HPSA_RS01920	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPSA_RS01960	COG0083	homoserine kinase activity
HPSA_RS01975	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPSA_RS01980	COG0779	Required for maturation of 30S ribosomal subunits
HPSA_RS01985	COG1408	metallophosphoesterase
HPSA_RS01990	COG0745	RESPONSE REGULATOR receiver
HPSA_RS01995	COG2404	hydrolase activity, acting on ester bonds
HPSA_RS02000	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPSA_RS02020	COG0006	proline dipeptidase activity
HPSA_RS02025	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPSA_RS02030	COG1419	protein localization to endoplasmic reticulum
HPSA_RS02035	COG0455	bacterial-type flagellum organization
HPSA_RS02050	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPSA_RS02055	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPSA_RS02055	COG1776	CheC inhibitor of MCP methylation
HPSA_RS02070	COG0735	belongs to the Fur family
HPSA_RS02075	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HPSA_RS02075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPSA_RS02080	COG0789	Transcriptional regulator
HPSA_RS02085	COG0484	heat shock protein binding
HPSA_RS02100	COG0745	RESPONSE REGULATOR receiver
HPSA_RS02105	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPSA_RS02105	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPSA_RS02115	COG0833	amino acid
HPSA_RS02120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPSA_RS02130	COG1028	Short-chain dehydrogenase reductase Sdr
HPSA_RS02145	COG0167	dihydroorotate dehydrogenase activity
HPSA_RS02150	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPSA_RS02225	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPSA_RS02230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPSA_RS02250	COG1217	gtp-binding protein TYPA
HPSA_RS02260	COG1217	gtp-binding protein TYPA
HPSA_RS02315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPSA_RS02320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPSA_RS02330	COG0824	Thioesterase
HPSA_RS02335	COG0733	neurotransmitter:sodium symporter activity
HPSA_RS02340	COG0733	neurotransmitter:sodium symporter activity
HPSA_RS02350	COG0592	DNA-directed DNA polymerase activity
HPSA_RS02355	COG0187	DNA topoisomerase II activity
HPSA_RS02370	COG0739	heme binding
HPSA_RS02370	COG0741	lytic transglycosylase activity
HPSA_RS02370	COG1196	nuclear chromosome segregation
HPSA_RS02385	COG0277	FAD linked oxidase domain protein
HPSA_RS02390	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPSA_RS02435	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPSA_RS02440	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPSA_RS02445	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPSA_RS02460	COG0174	glutamine synthetase
HPSA_RS02470	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPSA_RS02475	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPSA_RS02485	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPSA_RS02490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPSA_RS02510	COG0825	malonyl-CoA metabolic process
HPSA_RS02515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPSA_RS02525	COG1028	Short-chain dehydrogenase reductase Sdr
HPSA_RS02550	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPSA_RS02555	COG0628	permease
HPSA_RS02565	COG0012	GTP binding
HPSA_RS02580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPSA_RS02590	COG0698	ribose 5-phosphate isomerase
HPSA_RS02595	COG1994	Peptidase M50
HPSA_RS02600	COG0681	Belongs to the peptidase S26 family
HPSA_RS02605	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPSA_RS02625	COG0418	dihydroorotase activity
HPSA_RS02640	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPSA_RS02640	COG1776	CheC inhibitor of MCP methylation
HPSA_RS02645	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPSA_RS02650	COG1918	ferrous iron import across plasma membrane
HPSA_RS02670	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPSA_RS02670	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPSA_RS02675	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPSA_RS02720	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPSA_RS02725	COG0156	8-amino-7-oxononanoate synthase activity
HPSA_RS02730	COG0840	transmembrane signaling receptor activity
HPSA_RS02745	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPSA_RS02805	COG0784	Response regulator, receiver
HPSA_RS02805	COG0835	chemotaxis
HPSA_RS02810	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPSA_RS02820	COG3306	glycosyltransferase involved in LPS biosynthesis
HPSA_RS02830	COG3306	glycosyltransferase involved in LPS biosynthesis
HPSA_RS02840	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPSA_RS02845	COG1193	negative regulation of DNA recombination
HPSA_RS02860	COG0436	Aminotransferase
HPSA_RS02865	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPSA_RS02870	COG2171	N-acyltransferase activity
HPSA_RS02885	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPSA_RS02890	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HPSA_RS02895	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HPSA_RS02900	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HPSA_RS02905	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HPSA_RS02910	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HPSA_RS02930	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPSA_RS02935	COG0617	tRNA 3'-terminal CCA addition
HPSA_RS02945	COG0778	Nitroreductase
HPSA_RS02955	COG0762	integral membrane protein
HPSA_RS02980	COG1027	Aspartate ammonia-lyase
HPSA_RS02995	COG0560	Phosphoserine phosphatase
HPSA_RS03000	COG1528	Iron-storage protein
HPSA_RS03005	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HPSA_RS03015	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HPSA_RS03025	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPSA_RS03040	COG0328	RNA-DNA hybrid ribonuclease activity
HPSA_RS03045	COG0571	ribonuclease III activity
HPSA_RS03050	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPSA_RS03060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPSA_RS03100	COG4974	Belongs to the 'phage' integrase family
HPSA_RS03110	COG0730	response to heat
HPSA_RS03120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPSA_RS03135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPSA_RS03140	COG1338	Plays a role in the flagellum-specific transport system
HPSA_RS03150	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HPSA_RS03160	COG0183	Belongs to the thiolase family
HPSA_RS03165	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPSA_RS03170	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPSA_RS03175	COG2031	fatty acid transporter
HPSA_RS03185	COG0145	ligase activity
HPSA_RS03190	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HPSA_RS03195	COG4647	ligase activity
HPSA_RS03210	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPSA_RS03215	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPSA_RS03225	COG2204	response regulator
HPSA_RS03240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPSA_RS03250	COG0275	rRNA processing
HPSA_RS03265	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HPSA_RS03280	COG3177	Filamentation induced by cAMP protein fic
HPSA_RS03285	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPSA_RS03290	COG1137	ATPase activity
HPSA_RS03300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPSA_RS03305	COG1279	arginine transmembrane transporter activity
HPSA_RS03325	COG0252	asparaginase activity
HPSA_RS03330	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPSA_RS03345	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPSA_RS03350	COG0037	tRNA processing
HPSA_RS03375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPSA_RS03380	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPSA_RS03385	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPSA_RS03390	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPSA_RS03395	COG1181	Belongs to the D-alanine--D-alanine ligase family
HPSA_RS03405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPSA_RS03415	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPSA_RS03430	COG1162	GTPase activity
HPSA_RS03435	COG0564	pseudouridine synthase activity
HPSA_RS03445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPSA_RS03450	COG2884	Cell division ATP-binding protein ftsE
HPSA_RS03470	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPSA_RS03500	COG2056	Na+-H+ antiporter family
HPSA_RS03505	COG0534	Mate efflux family protein
HPSA_RS03525	COG0552	protein localization to endoplasmic reticulum
HPSA_RS03555	COG0746	molybdenum cofactor guanylyltransferase activity
HPSA_RS03560	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPSA_RS03570	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPSA_RS03580	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPSA_RS03590	COG1758	RNA polymerase activity
HPSA_RS03595	COG0528	UMP kinase activity
HPSA_RS03605	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPSA_RS03635	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPSA_RS03640	COG0653	protein targeting
HPSA_RS03660	COG2217	Heavy metal translocating P-type atpase
HPSA_RS03665	COG0606	chelatase, subunit chli
HPSA_RS03670	COG0242	peptide deformylase activity
HPSA_RS03680	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPSA_RS03695	COG0315	cyclic pyranopterin monophosphate synthase activity
HPSA_RS03700	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPSA_RS03705	COG0314	molybdopterin synthase activity
HPSA_RS03715	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPSA_RS03730	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPSA_RS03730	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPSA_RS03750	COG0736	holo-[acyl-carrier-protein] synthase activity
HPSA_RS03755	COG1580	Controls the rotational direction of flagella during chemotaxis
HPSA_RS03775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPSA_RS03780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPSA_RS03785	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPSA_RS03790	COG1360	Flagellar Motor Protein
HPSA_RS03800	COG1732	Glycine betaine
HPSA_RS03805	COG0517	IMP dehydrogenase activity
HPSA_RS03805	COG1125	glycine betaine transport
HPSA_RS03820	COG0322	excinuclease ABC activity
HPSA_RS03825	COG0460	homoserine dehydrogenase
HPSA_RS03830	COG0792	nuclease activity
HPSA_RS03835	COG3118	belongs to the thioredoxin family
HPSA_RS03840	COG0492	ferredoxin-NADP+ reductase activity
HPSA_RS03850	COG0724	RNA recognition motif
HPSA_RS03860	COG0517	IMP dehydrogenase activity
HPSA_RS03860	COG0516	GMP reductase activity
HPSA_RS03870	COG0237	dephospho-CoA kinase activity
HPSA_RS03885	COG1160	GTP binding
HPSA_RS03890	COG0776	regulation of translation
HPSA_RS03915	COG1086	Polysaccharide biosynthesis protein
HPSA_RS03920	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPSA_RS03930	COG0352	thiamine-phosphate diphosphorylase activity
HPSA_RS03935	COG0351	phosphomethylpyrimidine kinase
HPSA_RS03960	COG0671	phosphoesterase, PA-phosphatase related
HPSA_RS03970	COG0488	(ABC) transporter
HPSA_RS03980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPSA_RS03985	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPSA_RS03985	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPSA_RS03990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPSA_RS03995	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPSA_RS04005	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HPSA_RS04020	COG0756	dUTP diphosphatase activity
HPSA_RS04040	COG0375	protein maturation
HPSA_RS04045	COG1749	Flagellar hook protein flgE
HPSA_RS04050	COG2134	cdp-diacylglycerol pyrophosphatase
HPSA_RS04055	COG2824	Alkylphosphonate utilization operon protein PhnA
HPSA_RS04070	COG0753	catalase activity
HPSA_RS04090	COG0632	four-way junction helicase activity
HPSA_RS04100	COG0728	peptidoglycan biosynthetic process
HPSA_RS04105	COG0215	cysteine-tRNA ligase activity
HPSA_RS04120	COG1120	ATPase activity
HPSA_RS04125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPSA_RS04130	COG0300	oxidoreductase activity
HPSA_RS04135	COG1607	acyl-coa hydrolase
HPSA_RS04140	COG3309	Virulence-associated protein D
HPSA_RS04180	COG0409	Hydrogenase expression formation protein
HPSA_RS04185	COG0298	carbon dioxide binding
HPSA_RS04190	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HPSA_RS04205	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPSA_RS04210	COG0280	phosphate acetyltransferase
HPSA_RS04220	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HPSA_RS04225	COG1749	Flagellar hook protein flgE
HPSA_RS04225	COG1749	Flagellar hook protein flgE
HPSA_RS04270	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPSA_RS04275	COG0670	Belongs to the BI1 family
HPSA_RS04280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPSA_RS04295	COG1942	4-Oxalocrotonate Tautomerase
HPSA_RS04300	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPSA_RS04305	COG0585	pseudouridine synthase activity
HPSA_RS04310	COG0501	Belongs to the peptidase M48B family
HPSA_RS04315	COG0302	gtp cyclohydrolase
HPSA_RS04320	COG0142	geranyltranstransferase activity
HPSA_RS04335	COG0720	synthase
HPSA_RS04340	COG0602	queuosine metabolic process
HPSA_RS04360	COG0765	amino acid transport
HPSA_RS04365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPSA_RS04370	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPSA_RS04375	COG1115	amino acid carrier protein
HPSA_RS04380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPSA_RS04385	COG0251	oxidation-reduction process
HPSA_RS04415	COG1757	Na H antiporter
HPSA_RS04460	COG1192	Involved in chromosome partitioning
HPSA_RS04485	COG3041	Addiction module toxin RelE StbE family
HPSA_RS04510	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HPSA_RS04545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPSA_RS04550	COG3451	type IV secretory pathway VirB4
HPSA_RS04585	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPSA_RS04590	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPSA_RS04600	COG1546	Belongs to the CinA family
HPSA_RS04600	COG1058	Belongs to the CinA family
HPSA_RS04610	COG0778	Nitroreductase
HPSA_RS04615	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPSA_RS04620	COG0564	pseudouridine synthase activity
HPSA_RS04625	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPSA_RS04625	COG1519	Transferase
HPSA_RS04635	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPSA_RS04640	COG0752	glycyl-tRNA synthetase alpha subunit
HPSA_RS04645	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPSA_RS04660	COG1160	GTP binding
HPSA_RS04670	COG3309	Virulence-associated protein D
HPSA_RS04705	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPSA_RS04710	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPSA_RS04715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPSA_RS04725	COG0849	cell division
HPSA_RS04730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPSA_RS04750	COG0668	transmembrane transport
HPSA_RS04800	COG1166	arginine decarboxylase activity
HPSA_RS04815	COG0500	methyltransferase
HPSA_RS04825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPSA_RS04825	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPSA_RS04830	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPSA_RS04835	COG0668	transmembrane transport
HPSA_RS04870	COG0519	Catalyzes the synthesis of GMP from XMP
HPSA_RS04870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPSA_RS04890	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPSA_RS04895	COG0537	adenosine 5'-monophosphoramidase activity
HPSA_RS04905	COG0072	phenylalanine-tRNA ligase activity
HPSA_RS04905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPSA_RS04910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HPSA_RS04920	COG1185	polyribonucleotide nucleotidyltransferase activity
HPSA_RS04920	COG0539	negative regulation of cytoplasmic translation
HPSA_RS04930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPSA_RS04940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPSA_RS04950	COG0784	Response regulator, receiver
HPSA_RS04950	COG0835	chemotaxis
HPSA_RS04955	COG0784	Response regulator, receiver
HPSA_RS04955	COG0643	Histidine kinase
HPSA_RS04955	COG2198	Histidine kinase
HPSA_RS04960	COG0835	chemotaxis
HPSA_RS04965	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HPSA_RS04970	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPSA_RS04975	COG2226	methyltransferase
HPSA_RS04980	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPSA_RS05005	COG0501	Belongs to the peptidase M48B family
HPSA_RS05010	COG2890	protein-(glutamine-N5) methyltransferase activity
HPSA_RS05015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPSA_RS05025	COG1333	cytochrome c biogenesis protein
HPSA_RS05025	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPSA_RS05045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPSA_RS05060	COG0511	ligase activity, forming carbon-carbon bonds
HPSA_RS05065	COG0439	Biotin carboxylase
HPSA_RS05085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPSA_RS05095	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPSA_RS05140	COG4221	oxidoreductase activity
HPSA_RS05145	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPSA_RS05150	COG0800	Aldolase
HPSA_RS05155	COG0129	dihydroxy-acid dehydratase activity
HPSA_RS05160	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPSA_RS05165	COG0363	glucosamine-6-phosphate deaminase activity
HPSA_RS05175	COG1064	alcohol dehydrogenase
HPSA_RS05200	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPSA_RS05210	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPSA_RS05215	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPSA_RS05220	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPSA_RS05250	COG0405	Gamma-glutamyltransferase
HPSA_RS05285	COG1047	Peptidyl-prolyl cis-trans
HPSA_RS05295	COG2885	chlorophyll binding
HPSA_RS05310	COG0848	biopolymer transport protein
HPSA_RS05315	COG0811	peptide transport
HPSA_RS05320	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPSA_RS05345	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPSA_RS05355	COG1475	DNA binding
HPSA_RS05360	COG1192	Involved in chromosome partitioning
HPSA_RS05410	COG0336	Belongs to the RNA methyltransferase TrmD family
HPSA_RS05430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPSA_RS05435	COG0525	valine-tRNA ligase activity
HPSA_RS05445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPSA_RS05460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPSA_RS05465	COG2184	nucleotidyltransferase activity
HPSA_RS05475	COG0716	FMN binding
HPSA_RS05490	COG0492	ferredoxin-NADP+ reductase activity
HPSA_RS05500	COG0166	Belongs to the GPI family
HPSA_RS05520	COG1966	Carbon starvation protein
HPSA_RS05535	COG1126	abc transporter atp-binding protein
HPSA_RS05550	COG0738	Major facilitator superfamily
HPSA_RS05555	COG2252	PERMEase
HPSA_RS05575	COG0813	purine-nucleoside phosphorylase activity
HPSA_RS05580	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPSA_RS05585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPSA_RS05600	COG2814	Major facilitator Superfamily
HPSA_RS05605	COG0037	tRNA processing
HPSA_RS05610	COG0475	glutathione-regulated potassium exporter activity
HPSA_RS05610	COG0569	domain protein
HPSA_RS05635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPSA_RS05640	COG0124	histidyl-tRNA synthetase
HPSA_RS05660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPSA_RS05700	COG0250	Participates in transcription elongation, termination and antitermination
HPSA_RS05745	COG1132	(ABC) transporter
HPSA_RS05765	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPSA_RS05770	COG1185	polyribonucleotide nucleotidyltransferase activity
HPSA_RS05780	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPSA_RS05790	COG0151	Belongs to the GarS family
HPSA_RS05810	COG1131	(ABC) transporter
HPSA_RS05815	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPSA_RS05835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPSA_RS05840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPSA_RS05845	COG2863	cytochrome
HPSA_RS05855	COG0527	aspartate kinase activity
HPSA_RS05870	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPSA_RS05880	COG0697	spore germination
HPSA_RS05895	COG0505	Belongs to the CarA family
HPSA_RS05920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPSA_RS05940	COG0629	single-stranded DNA binding
HPSA_RS05950	COG1466	dna polymerase III delta subunit
HPSA_RS05955	COG0557	exoribonuclease II activity
HPSA_RS05960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPSA_RS05970	COG4174	ABC transporter (Permease)
HPSA_RS05975	COG4166	transmembrane transport
HPSA_RS05980	COG0180	Tryptophanyl-tRNA synthetase
HPSA_RS05990	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPSA_RS05995	COG0233	cytoplasmic translational termination
HPSA_RS06000	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPSA_RS06010	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPSA_RS06015	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPSA_RS06020	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPSA_RS06025	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPSA_RS06050	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HPSA_RS06055	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPSA_RS06060	COG0839	Belongs to the complex I subunit 6 family
HPSA_RS06065	COG0713	ATP synthesis coupled electron transport
HPSA_RS06070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPSA_RS06075	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPSA_RS06080	COG1007	ATP synthesis coupled electron transport
HPSA_RS06105	COG0133	tryptophan synthase activity
HPSA_RS06110	COG0135	phosphoribosylanthranilate isomerase activity
HPSA_RS06110	COG0134	indole-3-glycerol-phosphate synthase activity
HPSA_RS06115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPSA_RS06120	COG0512	Glutamine amidotransferase of anthranilate synthase
HPSA_RS06125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPSA_RS06130	COG0859	PFAM glycosyl transferase family 9
HPSA_RS06140	COG2353	YceI-like domain
HPSA_RS06145	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HPSA_RS06170	COG0202	RNA polymerase activity
HPSA_RS06195	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPSA_RS06200	COG0024	Methionine aminopeptidase
HPSA_RS06205	COG0201	protein transport
HPSA_RS06260	COG0255	Belongs to the universal ribosomal protein uL29 family
HPSA_RS06275	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPSA_RS06280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPSA_RS06300	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPSA_RS06330	COG0114	fumarate hydratase activity
HPSA_RS06345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPSA_RS06355	COG1687	branched-chain amino acid
HPSA_RS06360	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HPSA_RS06365	COG0484	heat shock protein binding
HPSA_RS06375	COG0482	sulfurtransferase activity
HPSA_RS06385	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPSA_RS06395	COG0811	peptide transport
HPSA_RS06400	COG0848	biopolymer transport protein
HPSA_RS06405	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPSA_RS06425	COG1045	serine acetyltransferase
HPSA_RS06450	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPSA_RS06455	COG0799	negative regulation of ribosome biogenesis
HPSA_RS06460	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPSA_RS06480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPSA_RS06485	COG1987	bacterial-type flagellum assembly
HPSA_RS06490	COG1157	protein secretion by the type III secretion system
HPSA_RS06495	COG4962	Type ii secretion system protein e
HPSA_RS06505	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPSA_RS06530	COG0517	IMP dehydrogenase activity
HPSA_RS06530	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPSA_RS06540	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPSA_RS06560	COG0788	formyltetrahydrofolate deformylase activity
HPSA_RS06565	COG0616	signal peptide processing
HPSA_RS06600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPSA_RS06610	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPSA_RS06620	COG0811	peptide transport
HPSA_RS06625	COG0848	biopolymer transport protein
HPSA_RS06645	COG0706	membrane insertase activity
HPSA_RS06655	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPSA_RS06695	COG3118	belongs to the thioredoxin family
HPSA_RS06700	COG1187	pseudouridine synthase activity
HPSA_RS06705	COG0587	DNA-directed DNA polymerase activity
HPSA_RS06730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPSA_RS06735	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPSA_RS06745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPSA_RS06780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPSA_RS06785	COG0163	prenyltransferase activity
HPSA_RS06805	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPSA_RS06820	COG2226	methyltransferase
HPSA_RS06825	COG1981	membrane
HPSA_RS06830	COG1739	Uncharacterized protein family UPF0029
HPSA_RS06845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPSA_RS06855	COG1253	flavin adenine dinucleotide binding
HPSA_RS06860	COG0306	phosphate transporter
HPSA_RS06865	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HPSA_RS06875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPSA_RS06890	COG0193	aminoacyl-tRNA hydrolase activity
HPSA_RS06925	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HPSA_RS06935	COG0786	glutamate:sodium symporter activity
HPSA_RS06945	COG0348	domain, Protein
HPSA_RS06950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPSA_RS06975	COG0195	Participates in both transcription termination and antitermination
HPSA_RS07010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPSA_RS07025	COG0708	Exodeoxyribonuclease III
HPSA_RS07060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPSA_RS07065	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HPSA_RS07085	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HPSA_RS07100	COG0010	Belongs to the arginase family
HPSA_RS07105	COG0686	Belongs to the AlaDH PNT family
HPSA_RS07110	COG1064	alcohol dehydrogenase
HPSA_RS07125	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPSA_RS07130	COG0497	DNA recombination
HPSA_RS07145	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPSA_RS07155	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPSA_RS07160	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HPSA_RS07180	COG1295	ribonuclease BN
HPSA_RS07185	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPSA_RS07190	COG3421	Type III restriction
HPSA_RS07195	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HPSA_RS07205	COG0287	Prephenate dehydrogenase
HPSA_RS07210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPSA_RS07215	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPSA_RS07220	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HPSA_RS07230	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPSA_RS07235	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPSA_RS07240	COG1077	Cell shape determining protein MreB Mrl
HPSA_RS07245	COG1792	Involved in formation and maintenance of cell shape
HPSA_RS07280	COG3451	type IV secretory pathway VirB4
HPSA_RS07285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPSA_RS07305	COG1754	DNA topoisomerase type I activity
HPSA_RS07305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPSA_RS07340	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HPSA_RS07380	COG1192	Involved in chromosome partitioning
HPSA_RS07440	COG0745	RESPONSE REGULATOR receiver
HPSA_RS07445	COG0642	Histidine kinase
HPSA_RS07450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPSA_RS07450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPSA_RS07455	COG0305	Participates in initiation and elongation during chromosome replication
HPSA_RS07465	COG0109	protoheme IX farnesyltransferase activity
HPSA_RS07485	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPSA_RS07490	COG0157	Belongs to the NadC ModD family
HPSA_RS07520	COG0793	Belongs to the peptidase S41A family
HPSA_RS07530	COG0204	Acyl-transferase
HPSA_RS07535	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPSA_RS07540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPSA_RS07545	COG0126	phosphoglycerate kinase activity
HPSA_RS07550	COG0598	Magnesium transport protein CorA
HPSA_RS07555	COG0861	Integral membrane protein TerC family
HPSA_RS07575	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPSA_RS07590	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPSA_RS07595	COG1862	Preprotein translocase
HPSA_RS07600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPSA_RS07605	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPSA_RS07615	COG0495	leucyl-tRNA aminoacylation
HPSA_RS07625	COG0285	dihydrofolate synthase activity
HPSA_RS07635	COG0739	heme binding
HPSA_RS07645	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPSA_RS07650	COG0723	plastoquinol--plastocyanin reductase activity
HPSA_RS07680	COG1106	Psort location Cytoplasmic, score
HPSA_RS07685	COG0768	penicillin binding
HPSA_RS07695	COG1558	bacterial-type flagellum-dependent cell motility
HPSA_RS07700	COG1815	bacterial-type flagellum-dependent cell motility
HPSA_RS07705	COG0772	Belongs to the SEDS family
HPSA_RS07720	COG0450	alkyl hydroperoxide reductase
HPSA_RS07735	COG0768	penicillin binding
HPSA_RS07745	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HPSA_RS07760	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HPSA_RS07765	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPSA_RS07770	COG1388	LysM domain
HPSA_RS07770	COG0741	lytic transglycosylase activity
HPSA_RS07775	COG0084	hydrolase, TatD family'
HPSA_RS07780	COG0307	riboflavin synthase, alpha
HPSA_RS07790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPSA_RS07795	COG2011	ABC-type metal ion transport system permease component
HPSA_RS07805	COG0671	phosphoesterase, PA-phosphatase related
HPSA_RS07810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPSA_RS07820	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPSA_RS07825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPSA_RS07830	COG4786	Flagellar basal body rod
HPSA_RS07835	COG4735	regulation of single-species biofilm formation
HPSA_RS07840	COG4735	regulation of single-species biofilm formation
HPSA_RS07850	COG4735	regulation of single-species biofilm formation
HPSA_RS07975	COG2194	sulfuric ester hydrolase activity