locus-tag	class	description
C2844_RS00005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2844_RS00010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2844_RS00015	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C2844_RS00020	COG0288	reversible hydration of carbon dioxide
C2844_RS00025	COG0284	orotidine-5'-phosphate decarboxylase activity
C2844_RS00030	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2844_RS00065	COG0459	protein refolding
C2844_RS00070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C2844_RS00080	COG0358	DNA primase activity
C2844_RS00085	COG0482	sulfurtransferase activity
C2844_RS00120	COG0784	Response regulator, receiver
C2844_RS00120	COG0835	chemotaxis
C2844_RS00130	COG0671	phosphoesterase, PA-phosphatase related
C2844_RS00135	COG2194	sulfuric ester hydrolase activity
C2844_RS00155	COG0372	Belongs to the citrate synthase family
C2844_RS00160	COG0538	isocitrate dehydrogenase activity
C2844_RS00170	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2844_RS00180	COG0589	response to stress
C2844_RS00185	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C2844_RS00190	COG0542	response to heat
C2844_RS00195	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C2844_RS00200	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2844_RS00240	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C2844_RS00260	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C2844_RS00265	COG2957	Belongs to the agmatine deiminase family
C2844_RS00295	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2844_RS00300	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2844_RS00300	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2844_RS00300	COG0506	proline dehydrogenase activity
C2844_RS00355	COG0829	nickel cation binding
C2844_RS00365	COG0830	nickel cation binding
C2844_RS00370	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C2844_RS00380	COG0804	urea catabolic process
C2844_RS00395	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2844_RS00400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2844_RS00405	COG0268	Binds directly to 16S ribosomal RNA
C2844_RS00410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2844_RS00435	COG0840	transmembrane signaling receptor activity
C2844_RS00455	COG0579	oxidoreductase
C2844_RS00465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2844_RS00470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2844_RS00475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2844_RS00510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2844_RS00520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2844_RS00525	COG0840	transmembrane signaling receptor activity
C2844_RS00530	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2844_RS00555	COG0737	Belongs to the 5'-nucleotidase family
C2844_RS00560	COG1854	S-ribosylhomocysteine lyase activity
C2844_RS00565	COG0626	cystathionine gamma-synthase activity
C2844_RS00570	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2844_RS00580	COG0443	Heat shock 70 kDa protein
C2844_RS00585	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2844_RS00590	COG1420	regulation of RNA biosynthetic process
C2844_RS00610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2844_RS00615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2844_RS00615	COG0551	DNA topoisomerase type I activity
C2844_RS00620	COG0731	radical SAM domain protein
C2844_RS00640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2844_RS00640	COG0574	Belongs to the PEP-utilizing enzyme family
C2844_RS00650	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2844_RS00655	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2844_RS00665	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2844_RS00705	COG1760	l-serine dehydratase
C2844_RS00710	COG0814	amino acid
C2844_RS00715	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C2844_RS00725	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2844_RS00735	COG1139	Iron-sulfur cluster binding protein
C2844_RS00740	COG0247	lactate metabolic process
C2844_RS00745	COG1620	l-lactate permease
C2844_RS00750	COG1620	l-lactate permease
C2844_RS00755	COG1194	a g-specific adenine glycosylase
C2844_RS00765	COG3278	Belongs to the heme-copper respiratory oxidase family
C2844_RS00810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2844_RS00815	COG0148	phosphopyruvate hydratase activity
C2844_RS00830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2844_RS00845	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2844_RS00850	COG0217	transcriptional regulatory protein
C2844_RS00855	COG0113	porphobilinogen synthase activity
C2844_RS00860	COG0642	Histidine kinase
C2844_RS00865	COG0745	RESPONSE REGULATOR receiver
C2844_RS00880	COG0826	peptidase U32
C2844_RS00890	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C2844_RS00895	COG0303	'Molybdopterin
C2844_RS00915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2844_RS00920	COG0191	fructose-bisphosphate aldolase activity
C2844_RS00930	COG2089	acid synthase
C2844_RS00935	COG1136	(ABC) transporter
C2844_RS00940	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C2844_RS00950	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2844_RS00955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2844_RS00980	COG2862	Uncharacterized protein family, UPF0114
C2844_RS00985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2844_RS00990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2844_RS00995	COG1053	succinate dehydrogenase
C2844_RS01005	COG0149	triose-phosphate isomerase activity
C2844_RS01010	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2844_RS01015	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2844_RS01020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C2844_RS01025	COG0105	UTP biosynthetic process
C2844_RS01040	COG0416	fatty acid biosynthetic process
C2844_RS01045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2844_RS01075	COG0489	protein tyrosine kinase activity
C2844_RS01090	COG0326	Molecular chaperone. Has ATPase activity
C2844_RS01095	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2844_RS01100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2844_RS01105	COG0445	tRNA wobble uridine modification
C2844_RS01110	COG0471	metal ion transport
C2844_RS01115	COG0575	Belongs to the CDS family
C2844_RS01120	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2844_RS01130	COG1881	PFAM PEBP family protein
C2844_RS01140	COG1104	cysteine desulfurase activity
C2844_RS01155	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2844_RS01160	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2844_RS01160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2844_RS01165	COG0730	response to heat
C2844_RS01175	COG0659	secondary active sulfate transmembrane transporter activity
C2844_RS01190	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C2844_RS01205	COG0754	glutathionylspermidine amidase activity
C2844_RS01215	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2844_RS01225	COG0181	hydroxymethylbilane synthase activity
C2844_RS01230	COG0442	prolyl-tRNA aminoacylation
C2844_RS01235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C2844_RS01255	COG0783	Belongs to the Dps family
C2844_RS01260	COG0642	Histidine kinase
C2844_RS01265	COG3951	Flagellar rod assembly protein muramidase FlgJ
C2844_RS01270	COG1706	bacterial-type flagellum-dependent cell motility
C2844_RS01275	COG0513	Belongs to the DEAD box helicase family
C2844_RS01290	COG4172	Belongs to the ABC transporter superfamily
C2844_RS01295	COG4239	(ABC) transporter, permease
C2844_RS01315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C2844_RS01330	COG0750	zinc metalloprotease
C2844_RS01335	COG1570	exodeoxyribonuclease VII activity
C2844_RS01360	COG0542	response to heat
C2844_RS01365	COG0785	Cytochrome C biogenesis protein
C2844_RS01370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2844_RS01375	COG0402	S-adenosylhomocysteine deaminase activity
C2844_RS01385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2844_RS01410	COG0727	PFAM Uncharacterised protein family (UPF0153)
C2844_RS01420	COG0134	indole-3-glycerol-phosphate synthase activity
C2844_RS01430	COG0248	Ppx GppA phosphatase
C2844_RS01435	COG0859	PFAM glycosyl transferase family 9
C2844_RS01445	COG0343	queuine tRNA-ribosyltransferase activity
C2844_RS01455	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2844_RS01465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2844_RS01470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2844_RS01490	COG0019	diaminopimelate decarboxylase activity
C2844_RS01505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2844_RS01530	COG0747	negative chemotaxis
C2844_RS01535	COG0601	transmembrane transport
C2844_RS01540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2844_RS01545	COG0444	Belongs to the ABC transporter superfamily
C2844_RS01550	COG4608	Belongs to the ABC transporter superfamily
C2844_RS01555	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2844_RS01570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2844_RS01585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2844_RS01590	COG0726	polysaccharide deacetylase
C2844_RS01600	COG0523	cobalamin synthesis protein
C2844_RS01610	COG3309	Virulence-associated protein D
C2844_RS01640	COG0748	coenzyme F420 binding
C2844_RS01645	COG0018	arginyl-trna synthetase
C2844_RS01650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2844_RS01655	COG0194	GDP metabolic process
C2844_RS01675	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C2844_RS01680	COG3980	spore coat polysaccharide biosynthesis protein
C2844_RS01685	COG3980	spore coat polysaccharide biosynthesis protein
C2844_RS01690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2844_RS01695	COG1663	tetraacyldisaccharide 4'-kinase activity
C2844_RS01700	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2844_RS01710	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2844_RS01715	COG2894	cell division
C2844_RS01720	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C2844_RS01725	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2844_RS01725	COG0758	DNA mediated transformation
C2844_RS01730	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2844_RS01785	COG0564	pseudouridine synthase activity
C2844_RS01790	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2844_RS01790	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C2844_RS01795	COG0504	CTP synthase activity
C2844_RS01805	COG1766	The M ring may be actively involved in energy transduction
C2844_RS01810	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2844_RS01820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2844_RS01825	COG0481	GTPase activity
C2844_RS01835	COG4221	oxidoreductase activity
C2844_RS01860	COG0101	tRNA pseudouridine synthase activity
C2844_RS01870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2844_RS01875	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2844_RS01885	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2844_RS01905	COG0439	Biotin carboxylase
C2844_RS01910	COG0511	ligase activity, forming carbon-carbon bonds
C2844_RS01925	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2844_RS01935	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2844_RS01945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2844_RS01945	COG1333	cytochrome c biogenesis protein
C2844_RS01955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2844_RS01960	COG2890	protein-(glutamine-N5) methyltransferase activity
C2844_RS01965	COG0501	Belongs to the peptidase M48B family
C2844_RS01990	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2844_RS01995	COG2226	methyltransferase
C2844_RS02000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2844_RS02005	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2844_RS02010	COG0835	chemotaxis
C2844_RS02015	COG0643	Histidine kinase
C2844_RS02015	COG0784	Response regulator, receiver
C2844_RS02015	COG2198	Histidine kinase
C2844_RS02020	COG0784	Response regulator, receiver
C2844_RS02020	COG0835	chemotaxis
C2844_RS02030	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2844_RS02035	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2844_RS02040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2844_RS02050	COG1185	polyribonucleotide nucleotidyltransferase activity
C2844_RS02050	COG0539	negative regulation of cytoplasmic translation
C2844_RS02060	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2844_RS02065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2844_RS02065	COG0072	phenylalanine-tRNA ligase activity
C2844_RS02070	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2844_RS02075	COG0537	adenosine 5'-monophosphoramidase activity
C2844_RS02080	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2844_RS02100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2844_RS02100	COG0519	Catalyzes the synthesis of GMP from XMP
C2844_RS02140	COG0668	transmembrane transport
C2844_RS02145	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2844_RS02150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2844_RS02150	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2844_RS02160	COG0500	methyltransferase
C2844_RS02175	COG1166	arginine decarboxylase activity
C2844_RS02260	COG0551	DNA topoisomerase type I activity
C2844_RS02260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2844_RS02265	COG3451	type IV secretory pathway VirB4
C2844_RS02370	COG3451	type IV secretory pathway VirB4
C2844_RS02400	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2844_RS02465	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C2844_RS02470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2844_RS02490	COG1217	gtp-binding protein TYPA
C2844_RS02560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2844_RS02565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2844_RS02575	COG0824	Thioesterase
C2844_RS02580	COG0733	neurotransmitter:sodium symporter activity
C2844_RS02585	COG0733	neurotransmitter:sodium symporter activity
C2844_RS02590	COG0733	neurotransmitter:sodium symporter activity
C2844_RS02600	COG0592	DNA-directed DNA polymerase activity
C2844_RS02605	COG0187	DNA topoisomerase II activity
C2844_RS02620	COG0739	heme binding
C2844_RS02620	COG0741	lytic transglycosylase activity
C2844_RS02620	COG1196	nuclear chromosome segregation
C2844_RS02635	COG0277	FAD linked oxidase domain protein
C2844_RS02640	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2844_RS02650	COG0174	glutamine synthetase
C2844_RS02660	COG0359	binds to the 23S rRNA
C2844_RS02665	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2844_RS02670	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2844_RS02675	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2844_RS02815	COG3451	type IV secretory pathway VirB4
C2844_RS02835	COG1842	Phage shock protein A
C2844_RS02845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2844_RS02850	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2844_RS02860	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2844_RS02885	COG0825	malonyl-CoA metabolic process
C2844_RS02890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2844_RS02895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2844_RS02900	COG1028	Short-chain dehydrogenase reductase Sdr
C2844_RS02925	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2844_RS02930	COG0628	permease
C2844_RS02940	COG0012	GTP binding
C2844_RS02945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2844_RS02955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2844_RS02965	COG0698	ribose 5-phosphate isomerase
C2844_RS02970	COG1994	Peptidase M50
C2844_RS02975	COG0681	Belongs to the peptidase S26 family
C2844_RS02980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2844_RS03000	COG0418	dihydroorotase activity
C2844_RS03015	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2844_RS03015	COG1776	CheC inhibitor of MCP methylation
C2844_RS03020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2844_RS03025	COG1918	ferrous iron import across plasma membrane
C2844_RS03045	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2844_RS03045	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2844_RS03050	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2844_RS03090	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2844_RS03095	COG0156	8-amino-7-oxononanoate synthase activity
C2844_RS03100	COG0840	transmembrane signaling receptor activity
C2844_RS03110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2844_RS03125	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2844_RS03165	COG1131	(ABC) transporter
C2844_RS03175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2844_RS03180	COG0784	Response regulator, receiver
C2844_RS03180	COG0835	chemotaxis
C2844_RS03185	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2844_RS03190	COG0563	adenylate kinase activity
C2844_RS03205	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C2844_RS03210	COG1193	negative regulation of DNA recombination
C2844_RS03220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2844_RS03225	COG0436	Aminotransferase
C2844_RS03230	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C2844_RS03235	COG2171	N-acyltransferase activity
C2844_RS03250	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2844_RS03255	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C2844_RS03260	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C2844_RS03265	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
C2844_RS03270	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2844_RS03275	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C2844_RS03295	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2844_RS03300	COG0617	tRNA 3'-terminal CCA addition
C2844_RS03310	COG0778	Nitroreductase
C2844_RS03315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2844_RS03320	COG0762	integral membrane protein
C2844_RS03340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2844_RS03345	COG1027	Aspartate ammonia-lyase
C2844_RS03360	COG0560	Phosphoserine phosphatase
C2844_RS03365	COG1528	Iron-storage protein
C2844_RS03370	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C2844_RS03375	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2844_RS03380	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C2844_RS03390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2844_RS03405	COG0328	RNA-DNA hybrid ribonuclease activity
C2844_RS03410	COG0571	ribonuclease III activity
C2844_RS03415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2844_RS03425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2844_RS03460	COG4974	Belongs to the 'phage' integrase family
C2844_RS03470	COG0730	response to heat
C2844_RS03480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2844_RS03495	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2844_RS03515	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C2844_RS03530	COG0183	Belongs to the thiolase family
C2844_RS03535	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2844_RS03540	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2844_RS03545	COG2031	fatty acid transporter
C2844_RS03555	COG0145	ligase activity
C2844_RS03560	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
C2844_RS03565	COG4647	ligase activity
C2844_RS03575	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2844_RS03580	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2844_RS03590	COG2204	response regulator
C2844_RS03595	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2844_RS03605	COG0275	rRNA processing
C2844_RS03615	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
C2844_RS03635	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2844_RS03640	COG1137	ATPase activity
C2844_RS03650	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2844_RS03655	COG1279	arginine transmembrane transporter activity
C2844_RS03675	COG0252	asparaginase activity
C2844_RS03680	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2844_RS03695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2844_RS03700	COG0037	tRNA processing
C2844_RS03725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2844_RS03730	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C2844_RS03735	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2844_RS03740	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2844_RS03745	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2844_RS03755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2844_RS03765	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2844_RS03775	COG0772	Belongs to the SEDS family
C2844_RS03785	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2844_RS03790	COG0564	pseudouridine synthase activity
C2844_RS03800	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2844_RS03805	COG2884	Cell division ATP-binding protein ftsE
C2844_RS03855	COG2056	Na+-H+ antiporter family
C2844_RS03860	COG0534	Mate efflux family protein
C2844_RS03865	COG1418	mRNA catabolic process
C2844_RS03880	COG0552	protein localization to endoplasmic reticulum
C2844_RS03905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2844_RS03910	COG0746	molybdenum cofactor guanylyltransferase activity
C2844_RS03915	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2844_RS03925	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2844_RS03935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2844_RS03940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2844_RS03945	COG1758	RNA polymerase activity
C2844_RS03950	COG0528	UMP kinase activity
C2844_RS03960	COG1049	propionate catabolic process, 2-methylcitrate cycle
C2844_RS03990	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2844_RS03995	COG0653	protein targeting
C2844_RS04020	COG2217	Heavy metal translocating P-type atpase
C2844_RS04025	COG0606	chelatase, subunit chli
C2844_RS04030	COG0242	peptide deformylase activity
C2844_RS04035	COG0740	serine-type endopeptidase activity
C2844_RS04040	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2844_RS04055	COG0315	cyclic pyranopterin monophosphate synthase activity
C2844_RS04060	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2844_RS04065	COG0314	molybdopterin synthase activity
C2844_RS04085	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2844_RS04085	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2844_RS04105	COG0736	holo-[acyl-carrier-protein] synthase activity
C2844_RS04110	COG1580	Controls the rotational direction of flagella during chemotaxis
C2844_RS04130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2844_RS04135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2844_RS04140	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2844_RS04145	COG1360	Flagellar Motor Protein
C2844_RS04155	COG1732	Glycine betaine
C2844_RS04160	COG0517	IMP dehydrogenase activity
C2844_RS04160	COG1125	glycine betaine transport
C2844_RS04175	COG0322	excinuclease ABC activity
C2844_RS04180	COG0460	homoserine dehydrogenase
C2844_RS04190	COG3118	belongs to the thioredoxin family
C2844_RS04195	COG0492	ferredoxin-NADP+ reductase activity
C2844_RS04205	COG0724	RNA recognition motif
C2844_RS04220	COG0516	GMP reductase activity
C2844_RS04220	COG0517	IMP dehydrogenase activity
C2844_RS04225	COG0154	amidase activity
C2844_RS04230	COG0237	dephospho-CoA kinase activity
C2844_RS04235	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C2844_RS04245	COG1160	GTP binding
C2844_RS04250	COG0776	regulation of translation
C2844_RS04275	COG1086	Polysaccharide biosynthesis protein
C2844_RS04280	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2844_RS04290	COG0352	thiamine-phosphate diphosphorylase activity
C2844_RS04295	COG0351	phosphomethylpyrimidine kinase
C2844_RS04300	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C2844_RS04325	COG0671	phosphoesterase, PA-phosphatase related
C2844_RS04335	COG0488	(ABC) transporter
C2844_RS04340	COG0516	GMP reductase activity
C2844_RS04345	COG1696	Membrane protein involved in D-alanine export
C2844_RS04355	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2844_RS04360	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C2844_RS04360	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C2844_RS04365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2844_RS04370	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2844_RS04380	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C2844_RS04395	COG0756	dUTP diphosphatase activity
C2844_RS04400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2844_RS04405	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2844_RS04415	COG0375	protein maturation
C2844_RS04420	COG1749	Flagellar hook protein flgE
C2844_RS04425	COG2134	cdp-diacylglycerol pyrophosphatase
C2844_RS04430	COG2824	Alkylphosphonate utilization operon protein PhnA
C2844_RS04445	COG0753	catalase activity
C2844_RS04455	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C2844_RS04485	COG0632	four-way junction helicase activity
C2844_RS04495	COG0728	peptidoglycan biosynthetic process
C2844_RS04500	COG0215	cysteine-tRNA ligase activity
C2844_RS04510	COG1120	ATPase activity
C2844_RS04515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2844_RS04520	COG0300	oxidoreductase activity
C2844_RS04525	COG1607	acyl-coa hydrolase
C2844_RS04530	COG3041	Addiction module toxin RelE StbE family
C2844_RS04540	COG3041	Addiction module toxin RelE StbE family
C2844_RS04575	COG0409	Hydrogenase expression formation protein
C2844_RS04580	COG0409	Hydrogenase expression formation protein
C2844_RS04585	COG0298	carbon dioxide binding
C2844_RS04590	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C2844_RS04625	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C2844_RS04630	COG1749	Flagellar hook protein flgE
C2844_RS04630	COG1749	Flagellar hook protein flgE
C2844_RS04685	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2844_RS04690	COG0670	Belongs to the BI1 family
C2844_RS04695	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2844_RS04710	COG1942	4-Oxalocrotonate Tautomerase
C2844_RS04720	COG0585	pseudouridine synthase activity
C2844_RS04725	COG0501	Belongs to the peptidase M48B family
C2844_RS04730	COG0302	gtp cyclohydrolase
C2844_RS04735	COG0142	geranyltranstransferase activity
C2844_RS04740	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C2844_RS04750	COG0720	synthase
C2844_RS04755	COG0602	queuosine metabolic process
C2844_RS04785	COG0765	amino acid transport
C2844_RS04790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2844_RS04795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2844_RS04800	COG1115	amino acid carrier protein
C2844_RS04805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2844_RS04810	COG0251	oxidation-reduction process
C2844_RS04840	COG1757	Na H antiporter
C2844_RS04860	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2844_RS04865	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2844_RS04875	COG1058	Belongs to the CinA family
C2844_RS04875	COG1546	Belongs to the CinA family
C2844_RS04885	COG0778	Nitroreductase
C2844_RS04895	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C2844_RS04900	COG0778	Nitroreductase
C2844_RS04905	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C2844_RS04910	COG0564	pseudouridine synthase activity
C2844_RS04915	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2844_RS04915	COG1519	Transferase
C2844_RS04925	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2844_RS04930	COG0752	glycyl-tRNA synthetase alpha subunit
C2844_RS04935	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2844_RS04940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2844_RS04955	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2844_RS04965	COG3309	Virulence-associated protein D
C2844_RS04990	COG0751	glycine-tRNA ligase activity
C2844_RS05000	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2844_RS05005	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2844_RS05010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2844_RS05020	COG0849	cell division
C2844_RS05025	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2844_RS05035	COG0750	zinc metalloprotease
C2844_RS05060	COG0668	transmembrane transport
C2844_RS05100	COG4974	Belongs to the 'phage' integrase family
C2844_RS05105	COG3550	peptidyl-serine autophosphorylation
C2844_RS05145	COG1192	Involved in chromosome partitioning
C2844_RS05205	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C2844_RS05210	COG0167	dihydroorotate dehydrogenase activity
C2844_RS05220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2844_RS05225	COG1028	Short-chain dehydrogenase reductase Sdr
C2844_RS05235	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2844_RS05240	COG0833	amino acid
C2844_RS05250	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C2844_RS05250	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2844_RS05255	COG0745	RESPONSE REGULATOR receiver
C2844_RS05275	COG0484	heat shock protein binding
C2844_RS05280	COG0789	Transcriptional regulator
C2844_RS05285	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C2844_RS05285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2844_RS05290	COG0735	belongs to the Fur family
C2844_RS05305	COG1776	CheC inhibitor of MCP methylation
C2844_RS05305	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2844_RS05310	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2844_RS05325	COG0455	bacterial-type flagellum organization
C2844_RS05330	COG1419	protein localization to endoplasmic reticulum
C2844_RS05335	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2844_RS05340	COG0006	proline dipeptidase activity
C2844_RS05355	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2844_RS05360	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2844_RS05365	COG2404	hydrolase activity, acting on ester bonds
C2844_RS05370	COG0745	RESPONSE REGULATOR receiver
C2844_RS05375	COG1408	metallophosphoesterase
C2844_RS05380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2844_RS05385	COG0779	Required for maturation of 30S ribosomal subunits
C2844_RS05390	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2844_RS05395	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C2844_RS05405	COG0083	homoserine kinase activity
C2844_RS05415	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C2844_RS05420	COG0850	regulation of cytokinetic process
C2844_RS05445	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2844_RS05450	COG2255	four-way junction helicase activity
C2844_RS05455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2844_RS05460	COG0805	protein transport
C2844_RS05465	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2844_RS05470	COG0357	Ribosomal RNA small subunit methyltransferase G
C2844_RS05495	COG0745	RESPONSE REGULATOR receiver
C2844_RS05500	COG2264	protein methyltransferase activity
C2844_RS05505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2844_RS05515	COG1183	phosphatidylcholine synthase activity
C2844_RS05520	COG2217	Heavy metal translocating P-type atpase
C2844_RS05525	COG2608	mercury ion transmembrane transporter activity
C2844_RS05545	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C2844_RS05555	COG1106	Psort location Cytoplasmic, score
C2844_RS05570	COG1132	(ABC) transporter
C2844_RS05580	COG0540	Belongs to the ATCase OTCase family
C2844_RS05590	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C2844_RS05595	COG0196	riboflavin kinase activity
C2844_RS05600	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2844_RS05610	COG1674	ftsk spoiiie
C2844_RS05620	COG0477	Major facilitator Superfamily
C2844_RS05625	COG4786	Flagellar basal body rod
C2844_RS05655	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2844_RS05660	COG0800	Aldolase
C2844_RS05665	COG0129	dihydroxy-acid dehydratase activity
C2844_RS05670	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2844_RS05675	COG0363	glucosamine-6-phosphate deaminase activity
C2844_RS05680	COG0837	glucose binding
C2844_RS05685	COG1064	alcohol dehydrogenase
C2844_RS05705	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2844_RS05715	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2844_RS05720	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2844_RS05725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2844_RS05735	COG0556	nucleotide-excision repair
C2844_RS05770	COG0405	Gamma-glutamyltransferase
C2844_RS05800	COG1047	Peptidyl-prolyl cis-trans
C2844_RS05810	COG2885	chlorophyll binding
C2844_RS05815	COG0823	Involved in the tonB-independent uptake of proteins
C2844_RS05825	COG0848	biopolymer transport protein
C2844_RS05830	COG0811	peptide transport
C2844_RS05835	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2844_RS05840	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2844_RS05845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2844_RS05860	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C2844_RS05870	COG1475	DNA binding
C2844_RS05875	COG1192	Involved in chromosome partitioning
C2844_RS05880	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C2844_RS05880	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C2844_RS05885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2844_RS05930	COG0336	Belongs to the RNA methyltransferase TrmD family
C2844_RS05935	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2844_RS05950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2844_RS05955	COG0525	valine-tRNA ligase activity
C2844_RS05965	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2844_RS05980	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2844_RS05985	COG2184	nucleotidyltransferase activity
C2844_RS05990	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2844_RS05995	COG0716	FMN binding
C2844_RS06010	COG0492	ferredoxin-NADP+ reductase activity
C2844_RS06020	COG0166	Belongs to the GPI family
C2844_RS06030	COG1966	Carbon starvation protein
C2844_RS06040	COG0765	amino acid transport
C2844_RS06045	COG1126	abc transporter atp-binding protein
C2844_RS06060	COG0738	Major facilitator superfamily
C2844_RS06065	COG2252	PERMEase
C2844_RS06080	COG0813	purine-nucleoside phosphorylase activity
C2844_RS06085	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C2844_RS06090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2844_RS06100	COG2814	Major facilitator Superfamily
C2844_RS06105	COG0037	tRNA processing
C2844_RS06110	COG0569	domain protein
C2844_RS06110	COG0475	glutathione-regulated potassium exporter activity
C2844_RS06115	COG0534	Mate efflux family protein
C2844_RS06120	COG2814	Major facilitator Superfamily
C2844_RS06140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2844_RS06145	COG0124	histidyl-tRNA synthetase
C2844_RS06150	COG0859	PFAM glycosyl transferase family 9
C2844_RS06160	COG0667	Aldo Keto reductase
C2844_RS06165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2844_RS06180	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2844_RS06180	COG0085	RNA polymerase activity
C2844_RS06190	COG0222	ribosome binding
C2844_RS06195	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2844_RS06210	COG0250	Participates in transcription elongation, termination and antitermination
C2844_RS06230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2844_RS06255	COG1132	(ABC) transporter
C2844_RS06275	COG1045	serine acetyltransferase
C2844_RS06295	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2844_RS06300	COG1185	polyribonucleotide nucleotidyltransferase activity
C2844_RS06320	COG0151	Belongs to the GarS family
C2844_RS06330	COG1131	(ABC) transporter
C2844_RS06335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2844_RS06355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2844_RS06360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2844_RS06365	COG2863	cytochrome
C2844_RS06370	COG0494	nUDIX hydrolase
C2844_RS06375	COG0527	aspartate kinase activity
C2844_RS06390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2844_RS06400	COG0697	spore germination
C2844_RS06415	COG0505	Belongs to the CarA family
C2844_RS06420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2844_RS06430	COG0424	maF-like protein
C2844_RS06435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2844_RS06460	COG0629	single-stranded DNA binding
C2844_RS06465	COG0360	Binds together with S18 to 16S ribosomal RNA
C2844_RS06470	COG1466	dna polymerase III delta subunit
C2844_RS06475	COG0557	exoribonuclease II activity
C2844_RS06480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2844_RS06490	COG4174	ABC transporter (Permease)
C2844_RS06495	COG4166	transmembrane transport
C2844_RS06500	COG0180	Tryptophanyl-tRNA synthetase
C2844_RS06510	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2844_RS06520	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2844_RS06535	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2844_RS06545	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2844_RS06550	COG0649	NAD binding
C2844_RS06570	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C2844_RS06575	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2844_RS06580	COG0839	Belongs to the complex I subunit 6 family
C2844_RS06585	COG0713	ATP synthesis coupled electron transport
C2844_RS06590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2844_RS06600	COG1007	ATP synthesis coupled electron transport
C2844_RS06620	COG0159	tryptophan synthase activity
C2844_RS06625	COG0133	tryptophan synthase activity
C2844_RS06630	COG0134	indole-3-glycerol-phosphate synthase activity
C2844_RS06630	COG0135	phosphoribosylanthranilate isomerase activity
C2844_RS06635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2844_RS06640	COG0512	Glutamine amidotransferase of anthranilate synthase
C2844_RS06645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2844_RS06660	COG0859	PFAM glycosyl transferase family 9
C2844_RS06670	COG2353	YceI-like domain
C2844_RS06675	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2844_RS06710	COG0202	RNA polymerase activity
C2844_RS06715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2844_RS06720	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2844_RS06735	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C2844_RS06740	COG0024	Methionine aminopeptidase
C2844_RS06745	COG0201	protein transport
C2844_RS06780	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C2844_RS06785	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C2844_RS06800	COG0255	Belongs to the universal ribosomal protein uL29 family
C2844_RS06810	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C2844_RS06815	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C2844_RS06820	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2844_RS06825	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2844_RS06835	COG0088	Forms part of the polypeptide exit tunnel
C2844_RS06840	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2844_RS06860	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2844_RS06870	COG0114	fumarate hydratase activity
C2844_RS06890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2844_RS06895	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2844_RS06900	COG1687	branched-chain amino acid
C2844_RS06905	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2844_RS06910	COG0484	heat shock protein binding
C2844_RS06925	COG0482	sulfurtransferase activity
C2844_RS06935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2844_RS06940	COG0864	Transcriptional regulator
C2844_RS06945	COG0811	peptide transport
C2844_RS06950	COG0848	biopolymer transport protein
C2844_RS06955	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C2844_RS06970	COG0861	Integral membrane protein TerC family
C2844_RS06975	COG0598	Magnesium transport protein CorA
C2844_RS06980	COG0126	phosphoglycerate kinase activity
C2844_RS06985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2844_RS06990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2844_RS06995	COG0204	Acyl-transferase
C2844_RS07005	COG0793	Belongs to the peptidase S41A family
C2844_RS07025	COG0157	Belongs to the NadC ModD family
C2844_RS07030	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2844_RS07035	COG0688	phosphatidylethanolamine metabolic process
C2844_RS07050	COG0109	protoheme IX farnesyltransferase activity
C2844_RS07060	COG0305	Participates in initiation and elongation during chromosome replication
C2844_RS07065	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2844_RS07065	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2844_RS07070	COG0642	Histidine kinase
C2844_RS07075	COG0745	RESPONSE REGULATOR receiver
C2844_RS07120	COG1792	Involved in formation and maintenance of cell shape
C2844_RS07125	COG1077	Cell shape determining protein MreB Mrl
C2844_RS07130	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C2844_RS07135	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2844_RS07140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2844_RS07150	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C2844_RS07155	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2844_RS07160	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2844_RS07165	COG0287	Prephenate dehydrogenase
C2844_RS07190	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C2844_RS07195	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2844_RS07235	COG0497	DNA recombination
C2844_RS07240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2844_RS07255	COG0686	Belongs to the AlaDH PNT family
C2844_RS07260	COG0010	Belongs to the arginase family
C2844_RS07265	COG4772	TonB-dependent receptor
C2844_RS07275	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2844_RS07295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2844_RS07300	COG1295	ribonuclease BN
C2844_RS07345	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2844_RS07350	COG0799	negative regulation of ribosome biogenesis
C2844_RS07355	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2844_RS07370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2844_RS07375	COG1987	bacterial-type flagellum assembly
C2844_RS07380	COG1157	protein secretion by the type III secretion system
C2844_RS07385	COG4962	Type ii secretion system protein e
C2844_RS07390	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2844_RS07395	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2844_RS07415	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2844_RS07420	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2844_RS07420	COG0517	IMP dehydrogenase activity
C2844_RS07425	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2844_RS07430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2844_RS07450	COG0788	formyltetrahydrofolate deformylase activity
C2844_RS07495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2844_RS07500	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2844_RS07505	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2844_RS07515	COG0811	peptide transport
C2844_RS07520	COG0848	biopolymer transport protein
C2844_RS07530	COG0594	ribonuclease P activity
C2844_RS07535	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2844_RS07540	COG0706	membrane insertase activity
C2844_RS07550	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2844_RS07585	COG3118	belongs to the thioredoxin family
C2844_RS07590	COG1187	pseudouridine synthase activity
C2844_RS07620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2844_RS07625	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2844_RS07635	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2844_RS07645	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2844_RS07645	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2844_RS07665	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2844_RS07670	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2844_RS07675	COG0163	prenyltransferase activity
C2844_RS07695	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2844_RS07705	COG1722	exodeoxyribonuclease VII activity
C2844_RS07710	COG2226	methyltransferase
C2844_RS07715	COG1981	membrane
C2844_RS07720	COG1739	Uncharacterized protein family UPF0029
C2844_RS07735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2844_RS07745	COG1253	flavin adenine dinucleotide binding
C2844_RS07750	COG0306	phosphate transporter
C2844_RS07755	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2844_RS07765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2844_RS07770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2844_RS07775	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2844_RS07780	COG0193	aminoacyl-tRNA hydrolase activity
C2844_RS07810	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2844_RS07820	COG0786	glutamate:sodium symporter activity
C2844_RS07830	COG0348	domain, Protein
C2844_RS07835	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2844_RS07855	COG1921	L-seryl-tRNASec selenium transferase activity
C2844_RS07860	COG0195	Participates in both transcription termination and antitermination
C2844_RS07895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2844_RS07910	COG0708	Exodeoxyribonuclease III
C2844_RS07925	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2844_RS07940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2844_RS07945	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C2844_RS07990	COG0723	plastoquinol--plastocyanin reductase activity
C2844_RS07995	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2844_RS08005	COG0739	heme binding
C2844_RS08015	COG0285	dihydrofolate synthase activity
C2844_RS08025	COG0495	leucyl-tRNA aminoacylation
C2844_RS08035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2844_RS08040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2844_RS08045	COG1862	Preprotein translocase
C2844_RS08050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2844_RS08055	COG1074	ATP-dependent DNA helicase activity
C2844_RS08060	COG0052	Belongs to the universal ribosomal protein uS2 family
C2844_RS08065	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2844_RS08070	COG0768	penicillin binding
C2844_RS08085	COG1558	bacterial-type flagellum-dependent cell motility
C2844_RS08090	COG1815	bacterial-type flagellum-dependent cell motility
C2844_RS08095	COG0772	Belongs to the SEDS family
C2844_RS08110	COG0450	alkyl hydroperoxide reductase
C2844_RS08120	COG0768	penicillin binding
C2844_RS08130	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2844_RS08145	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2844_RS08150	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2844_RS08155	COG0741	lytic transglycosylase activity
C2844_RS08155	COG1388	LysM domain
C2844_RS08160	COG0084	hydrolase, TatD family'
C2844_RS08165	COG0307	riboflavin synthase, alpha
C2844_RS08175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2844_RS08180	COG2011	ABC-type metal ion transport system permease component
C2844_RS08195	COG0671	phosphoesterase, PA-phosphatase related
C2844_RS08200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2844_RS08205	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2844_RS08210	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2844_RS08215	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2844_RS08220	COG4786	Flagellar basal body rod