locus-tag	class	description
HM1_RS00010	COG3852	Histidine kinase
HM1_RS00030	COG3853	Toxic anion resistance protein (TelA)
HM1_RS00105	COG3344	reverse transcriptase
HM1_RS00250	COG0519	Catalyzes the synthesis of GMP from XMP
HM1_RS00250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HM1_RS00255	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HM1_RS00270	COG0521	Mo-molybdopterin cofactor biosynthetic process
HM1_RS00280	COG0315	cyclic pyranopterin monophosphate synthase activity
HM1_RS00285	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HM1_RS00300	COG0347	Belongs to the P(II) protein family
HM1_RS00310	COG0730	response to heat
HM1_RS00315	COG1960	acyl-CoA dehydrogenase activity
HM1_RS00320	COG0183	Belongs to the thiolase family
HM1_RS00325	COG1024	Enoyl-CoA hydratase
HM1_RS00325	COG1250	3-hydroxyacyl-CoA dehydrogenase
HM1_RS00330	COG1309	transcriptional regulator
HM1_RS00335	COG0318	PFAM AMP-dependent synthetase and ligase
HM1_RS00345	COG0205	6-phosphofructokinase activity
HM1_RS00350	COG0825	malonyl-CoA metabolic process
HM1_RS00355	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HM1_RS00385	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HM1_RS00390	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HM1_RS00395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HM1_RS00400	COG1247	-acetyltransferase
HM1_RS00410	COG0318	PFAM AMP-dependent synthetase and ligase
HM1_RS00420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HM1_RS00425	COG2873	o-acetylhomoserine
HM1_RS00430	COG2333	competence protein COMEC
HM1_RS00430	COG0658	competence protein
HM1_RS00455	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HM1_RS00460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HM1_RS00485	COG0297	glycogen (starch) synthase activity
HM1_RS00490	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HM1_RS00495	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HM1_RS00550	COG1592	Rubrerythrin
HM1_RS00560	COG0084	hydrolase, TatD family'
HM1_RS00605	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HM1_RS00620	COG3693	PFAM glycoside hydrolase, family 10
HM1_RS00640	COG3693	PFAM glycoside hydrolase, family 10
HM1_RS00680	COG3344	reverse transcriptase
HM1_RS00690	COG0745	RESPONSE REGULATOR receiver
HM1_RS00785	COG0739	heme binding
HM1_RS00805	COG4974	Belongs to the 'phage' integrase family
HM1_RS00810	COG4974	Belongs to the 'phage' integrase family
HM1_RS00900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HM1_RS00915	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HM1_RS00935	COG2088	sporulation resulting in formation of a cellular spore
HM1_RS01030	COG3706	GGDEF domain
HM1_RS01030	COG2203	Gaf domain
HM1_RS01030	COG5001	Diguanylate cyclase
HM1_RS01030	COG4251	negative regulation of phosphorylation
HM1_RS01045	COG1164	Oligoendopeptidase f
HM1_RS01080	COG3842	ATPase activity
HM1_RS01085	COG0426	domain, Protein
HM1_RS01100	COG1595	DNA-templated transcription, initiation
HM1_RS01115	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HM1_RS01120	COG2002	toxin-antitoxin pair type II binding
HM1_RS01130	COG0826	peptidase U32
HM1_RS01135	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HM1_RS01140	COG3906	Belongs to the UPF0473 family
HM1_RS01145	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HM1_RS01155	COG4472	Bacterial protein of unknown function (DUF965)
HM1_RS01160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HM1_RS01165	COG4822	anaerobic cobalamin biosynthetic process
HM1_RS01185	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HM1_RS01225	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HM1_RS01230	COG1518	maintenance of DNA repeat elements
HM1_RS01230	COG1468	defense response to virus
HM1_RS01260	COG1203	CRISPR-associated helicase, Cas3
HM1_RS01265	COG0011	TIGRFAM Protein of
HM1_RS01280	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HM1_RS01305	COG1067	ATP-dependent peptidase activity
HM1_RS01335	COG0411	ABC transporter
HM1_RS01345	COG0559	Belongs to the binding-protein-dependent transport system permease family
HM1_RS01355	COG0683	leucine binding
HM1_RS01365	COG0367	asparagine synthase
HM1_RS01405	COG0697	spore germination
HM1_RS01410	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HM1_RS01415	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HM1_RS01420	COG1067	ATP-dependent peptidase activity
HM1_RS01420	COG0470	DNA polymerase III
HM1_RS01425	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HM1_RS01430	COG0740	serine-type endopeptidase activity
HM1_RS01435	COG0544	peptidyl-prolyl cis-trans isomerase activity
HM1_RS01460	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HM1_RS01475	COG1924	4 iron, 4 sulfur cluster binding
HM1_RS01485	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HM1_RS01495	COG0428	transporter
HM1_RS01500	COG0730	response to heat
HM1_RS01520	COG2076	Multidrug Resistance protein
HM1_RS01535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HM1_RS01540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HM1_RS01550	COG4869	propanediol catabolic process
HM1_RS01565	COG1776	CheC inhibitor of MCP methylation
HM1_RS01585	COG0720	synthase
HM1_RS01590	COG0613	PHP domain protein
HM1_RS01595	COG1773	rubredoxin
HM1_RS01595	COG1592	Rubrerythrin
HM1_RS01605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HM1_RS01620	COG1136	(ABC) transporter
HM1_RS01625	COG0577	efflux transmembrane transporter activity
HM1_RS01625	COG1136	(ABC) transporter
HM1_RS01635	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HM1_RS01650	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HM1_RS01665	COG0861	Integral membrane protein TerC family
HM1_RS01695	COG0840	transmembrane signaling receptor activity
HM1_RS01715	COG2176	DNA-directed DNA polymerase activity
HM1_RS01720	COG1408	metallophosphoesterase
HM1_RS01725	COG3424	synthase
HM1_RS01730	COG1755	Isoprenylcysteine carboxyl methyltransferase
HM1_RS01750	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HM1_RS01780	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HM1_RS01785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HM1_RS01790	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HM1_RS01800	COG2183	response to ionizing radiation
HM1_RS01820	COG0116	Belongs to the methyltransferase superfamily
HM1_RS01840	COG3344	reverse transcriptase
HM1_RS01855	COG0511	ligase activity, forming carbon-carbon bonds
HM1_RS01865	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM1_RS01865	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM1_RS01870	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM1_RS01870	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM1_RS01875	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HM1_RS01880	COG0045	succinate-CoA ligase (ADP-forming) activity
HM1_RS01885	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HM1_RS01890	COG1053	succinate dehydrogenase
HM1_RS01895	COG2009	succinate dehydrogenase
HM1_RS01900	COG0492	ferredoxin-NADP+ reductase activity
HM1_RS01905	COG1620	l-lactate permease
HM1_RS01920	COG0277	FAD linked oxidase domain protein
HM1_RS01925	COG1139	Iron-sulfur cluster binding protein
HM1_RS01930	COG1556	Lactate utilization protein
HM1_RS01950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HM1_RS01950	COG0674	pyruvate-flavodoxin oxidoreductase activity
HM1_RS01960	COG0842	Transport permease protein
HM1_RS01975	COG1234	tRNA 3'-trailer cleavage
HM1_RS01980	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HM1_RS01990	COG4632	Exopolysaccharide biosynthesis protein
HM1_RS01990	COG5434	Belongs to the glycosyl hydrolase 28 family
HM1_RS01995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HM1_RS02000	COG0427	acetyl-CoA hydrolase
HM1_RS02005	COG0861	Integral membrane protein TerC family
HM1_RS02050	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HM1_RS02075	COG1924	4 iron, 4 sulfur cluster binding
HM1_RS02100	COG0697	spore germination
HM1_RS02115	COG1191	sigma factor activity
HM1_RS02120	COG2172	sigma factor antagonist activity
HM1_RS02125	COG1366	Belongs to the anti-sigma-factor antagonist family
HM1_RS02130	COG1686	Belongs to the peptidase S11 family
HM1_RS02150	COG4974	Belongs to the 'phage' integrase family
HM1_RS02170	COG1300	Membrane
HM1_RS02185	COG2195	Cleaves the N-terminal amino acid of tripeptides
HM1_RS02195	COG0840	transmembrane signaling receptor activity
HM1_RS02200	COG0745	RESPONSE REGULATOR receiver
HM1_RS02205	COG0750	zinc metalloprotease
HM1_RS02210	COG0497	DNA recombination
HM1_RS02215	COG1438	arginine binding
HM1_RS02230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HM1_RS02240	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HM1_RS02245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HM1_RS02260	COG1722	exodeoxyribonuclease VII activity
HM1_RS02265	COG1570	exodeoxyribonuclease VII activity
HM1_RS02270	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HM1_RS02270	COG0493	'glutamate synthase
HM1_RS02280	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HM1_RS02285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HM1_RS02295	COG1302	Protein conserved in bacteria
HM1_RS02300	COG0439	Biotin carboxylase
HM1_RS02355	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HM1_RS02360	COG0006	proline dipeptidase activity
HM1_RS02365	COG0312	modulator of DNA gyrase
HM1_RS02370	COG0312	modulator of DNA gyrase
HM1_RS02385	COG4970	Tfp pilus assembly protein FimT
HM1_RS02415	COG1459	type II secretion system
HM1_RS02440	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HM1_RS02450	COG1459	type II secretion system
HM1_RS02460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HM1_RS02465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HM1_RS02470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HM1_RS02475	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HM1_RS02480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HM1_RS02485	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HM1_RS02490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HM1_RS02495	COG0284	orotidine-5'-phosphate decarboxylase activity
HM1_RS02520	COG3773	Cell wall hydrolase
HM1_RS02540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HM1_RS02550	COG2814	Major facilitator Superfamily
HM1_RS02555	COG1566	PFAM secretion protein HlyD family protein
HM1_RS02560	COG1566	PFAM secretion protein HlyD family protein
HM1_RS02565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HM1_RS02575	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
HM1_RS02580	COG2119	membrane
HM1_RS02590	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HM1_RS02595	COG0564	pseudouridine synthase activity
HM1_RS02610	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HM1_RS02615	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HM1_RS02625	COG0310	cobalt ion transport
HM1_RS02650	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HM1_RS02665	COG0351	phosphomethylpyrimidine kinase
HM1_RS02675	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HM1_RS02680	COG0784	Response regulator, receiver
HM1_RS02680	COG3437	response regulator, receiver
HM1_RS02685	COG1151	hydroxylamine reductase activity
HM1_RS02690	COG0318	PFAM AMP-dependent synthetase and ligase
HM1_RS02705	COG1929	Belongs to the glycerate kinase type-1 family
HM1_RS02710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HM1_RS02720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HM1_RS02740	COG1857	crispr-associated protein
HM1_RS02775	COG2719	SpoVR family
HM1_RS02780	COG0489	protein tyrosine kinase activity
HM1_RS02785	COG0765	amino acid transport
HM1_RS02790	COG0765	amino acid transport
HM1_RS02795	COG3344	reverse transcriptase
HM1_RS02800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HM1_RS02820	COG2718	Belongs to the UPF0229 family
HM1_RS02825	COG2766	serine protein kinase
HM1_RS02830	COG0840	transmembrane signaling receptor activity
HM1_RS02835	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HM1_RS02925	COG0326	Molecular chaperone. Has ATPase activity
HM1_RS02950	COG3546	catalase activity
HM1_RS02955	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HM1_RS02970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HM1_RS02975	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HM1_RS02980	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HM1_RS02985	COG0148	phosphopyruvate hydratase activity
HM1_RS02990	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HM1_RS03000	COG0149	triose-phosphate isomerase activity
HM1_RS03005	COG0126	phosphoglycerate kinase activity
HM1_RS03015	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HM1_RS03020	COG0110	maltose O-acetyltransferase activity
HM1_RS03025	COG1481	regulation of sporulation
HM1_RS03030	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HM1_RS03035	COG1660	Displays ATPase and GTPase activities
HM1_RS03040	COG1640	4-alpha-glucanotransferase
HM1_RS03050	COG1950	PFAM Membrane protein of
HM1_RS03055	COG0322	excinuclease ABC activity
HM1_RS03060	COG0166	Belongs to the GPI family
HM1_RS03075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HM1_RS03085	COG0556	nucleotide-excision repair
HM1_RS03095	COG4191	Histidine kinase
HM1_RS03105	COG3901	Regulator of nitric oxide reductase transcription
HM1_RS03105	COG0348	domain, Protein
HM1_RS03125	COG0798	PFAM Bile acid sodium symporter
HM1_RS03155	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HM1_RS03175	COG3409	Peptidoglycan-binding domain 1 protein
HM1_RS03175	COG0793	Belongs to the peptidase S41A family
HM1_RS03180	COG0739	heme binding
HM1_RS03185	COG2177	Part of the ABC transporter FtsEX involved in
HM1_RS03190	COG2884	Cell division ATP-binding protein ftsE
HM1_RS03195	COG3958	Transketolase
HM1_RS03200	COG3959	Transketolase, thiamine diphosphate binding domain
HM1_RS03205	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HM1_RS03210	COG0653	protein targeting
HM1_RS03220	COG2604	Protein of unknown function DUF115
HM1_RS03225	COG1126	abc transporter atp-binding protein
HM1_RS03230	COG0765	amino acid transport
HM1_RS03245	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HM1_RS03250	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HM1_RS03265	COG1728	Protein conserved in bacteria
HM1_RS03300	COG1028	Short-chain dehydrogenase reductase Sdr
HM1_RS03310	COG2089	acid synthase
HM1_RS03315	COG0562	UDP-galactopyranose mutase
HM1_RS03325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HM1_RS03340	COG0463	Glycosyl transferase, family 2
HM1_RS03380	COG0438	transferase activity, transferring glycosyl groups
HM1_RS03460	COG1516	flagellar protein fliS
HM1_RS03470	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HM1_RS03480	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HM1_RS03485	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HM1_RS03495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HM1_RS03540	COG2197	response regulator
HM1_RS03555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HM1_RS03565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HM1_RS03580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HM1_RS03585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HM1_RS03615	COG2076	Multidrug Resistance protein
HM1_RS03630	COG0463	Glycosyl transferase, family 2
HM1_RS03645	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HM1_RS03650	COG1959	2 iron, 2 sulfur cluster binding
HM1_RS03655	COG4208	sulfate ABC transporter
HM1_RS03660	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HM1_RS03665	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HM1_RS03680	COG0175	sulfate reduction
HM1_RS03695	COG0579	oxidoreductase
HM1_RS03740	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HM1_RS03750	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HM1_RS03755	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HM1_RS03790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HM1_RS03805	COG0438	transferase activity, transferring glycosyl groups
HM1_RS03850	COG1595	DNA-templated transcription, initiation
HM1_RS03860	COG1404	Belongs to the peptidase S8 family
HM1_RS03875	COG2373	Large extracellular alpha-helical protein
HM1_RS03900	COG4786	Flagellar basal body rod
HM1_RS03905	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HM1_RS03915	COG1609	Transcriptional regulator
HM1_RS03925	COG2385	sporulation resulting in formation of a cellular spore
HM1_RS03930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HM1_RS03945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HM1_RS03950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HM1_RS03955	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HM1_RS03960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HM1_RS03965	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HM1_RS03970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HM1_RS03975	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HM1_RS03980	COG0356	it plays a direct role in the translocation of protons across the membrane
HM1_RS03995	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HM1_RS04005	COG2131	deaminase
HM1_RS04010	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HM1_RS04015	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HM1_RS04020	COG4475	Protein of unknown function (DUF436)
HM1_RS04025	COG0698	ribose 5-phosphate isomerase
HM1_RS04035	COG1971	Probably functions as a manganese efflux pump
HM1_RS04040	COG0009	L-threonylcarbamoyladenylate synthase
HM1_RS04045	COG2890	protein-(glutamine-N5) methyltransferase activity
HM1_RS04050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HM1_RS04055	COG3872	metal-dependent enzyme
HM1_RS04060	COG0254	rRNA binding
HM1_RS04065	COG0739	heme binding
HM1_RS04075	COG1494	fructose-1,6-bisphosphatase
HM1_RS04080	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HM1_RS04105	COG0616	signal peptide processing
HM1_RS04110	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HM1_RS04120	COG0504	CTP synthase activity
HM1_RS04130	COG0018	arginyl-trna synthetase
HM1_RS04140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HM1_RS04145	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HM1_RS04165	COG0583	DNA-binding transcription factor activity
HM1_RS04170	COG2855	membrane
HM1_RS04175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HM1_RS04205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HM1_RS04215	COG2323	membrane
HM1_RS04235	COG2002	toxin-antitoxin pair type II binding
HM1_RS04250	COG0493	'glutamate synthase
HM1_RS04255	COG0070	glutamate synthase
HM1_RS04255	COG0069	glutamate synthase activity
HM1_RS04255	COG0067	glutamate synthase
HM1_RS04260	COG1671	Belongs to the UPF0178 family
HM1_RS04265	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HM1_RS04270	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HM1_RS04275	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HM1_RS04275	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HM1_RS04305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HM1_RS04325	COG0351	phosphomethylpyrimidine kinase
HM1_RS04345	COG0464	growth
HM1_RS04375	COG1252	NADH dehydrogenase
HM1_RS04410	COG1643	Atp-dependent helicase
HM1_RS04425	COG0493	'glutamate synthase
HM1_RS04430	COG2414	aldehyde ferredoxin oxidoreductase
HM1_RS04440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HM1_RS04450	COG0436	Aminotransferase
HM1_RS04455	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HM1_RS04470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HM1_RS04475	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HM1_RS04480	COG2264	protein methyltransferase activity
HM1_RS04485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HM1_RS04500	COG0492	ferredoxin-NADP+ reductase activity
HM1_RS04515	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HM1_RS04530	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HM1_RS04535	COG0288	reversible hydration of carbon dioxide
HM1_RS04540	COG0305	Participates in initiation and elongation during chromosome replication
HM1_RS04545	COG0470	DNA polymerase III
HM1_RS04545	COG1067	ATP-dependent peptidase activity
HM1_RS04550	COG0359	binds to the 23S rRNA
HM1_RS04555	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HM1_RS04565	COG0629	single-stranded DNA binding
HM1_RS04570	COG0012	GTP binding
HM1_RS04585	COG0668	transmembrane transport
HM1_RS04600	COG1362	aminopeptidase activity
HM1_RS04625	COG4581	dead DEAH box helicase
HM1_RS04635	COG0701	Predicted permease
HM1_RS04640	COG0640	Transcriptional regulator
HM1_RS04650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HM1_RS04655	COG2814	Major facilitator Superfamily
HM1_RS04660	COG2707	UPF0756 membrane protein
HM1_RS04665	COG2045	Belongs to the ComB family
HM1_RS04670	COG1809	phosphosulfolactate synthase activity
HM1_RS04675	COG0726	polysaccharide deacetylase
HM1_RS04685	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HM1_RS04700	COG0697	spore germination
HM1_RS04705	COG3344	reverse transcriptase
HM1_RS04710	COG3344	reverse transcriptase
HM1_RS04770	COG3949	Membrane
HM1_RS04795	COG1811	Na channel or pump
HM1_RS04800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HM1_RS04805	COG1475	DNA binding
HM1_RS04810	COG1192	Involved in chromosome partitioning
HM1_RS04820	COG0445	tRNA wobble uridine modification
HM1_RS04825	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HM1_RS04830	COG1847	R3H domain protein
HM1_RS04835	COG0706	membrane insertase activity
HM1_RS04840	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HM1_RS04845	COG0594	ribonuclease P activity
HM1_RS04850	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HM1_RS04855	COG0592	DNA-directed DNA polymerase activity
HM1_RS04860	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HM1_RS04870	COG0187	DNA topoisomerase II activity
HM1_RS04875	COG1960	acyl-CoA dehydrogenase activity
HM1_RS04880	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM1_RS04880	COG1703	isobutyryl-CoA mutase activity
HM1_RS04880	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM1_RS04885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HM1_RS04890	COG0183	Belongs to the thiolase family
HM1_RS04895	COG1250	3-hydroxyacyl-CoA dehydrogenase
HM1_RS04900	COG1960	acyl-CoA dehydrogenase activity
HM1_RS04905	COG1024	Enoyl-CoA hydratase
HM1_RS04910	COG2086	electron transfer activity
HM1_RS04915	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HM1_RS04920	COG0247	lactate metabolic process
HM1_RS04920	COG2181	nitrate reductase activity
HM1_RS04925	COG0778	Nitroreductase
HM1_RS04960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HM1_RS04965	COG1309	transcriptional regulator
HM1_RS04970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HM1_RS04975	COG1131	(ABC) transporter
HM1_RS05010	COG1984	allophanate hydrolase subunit 2
HM1_RS05015	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HM1_RS05025	COG0347	Belongs to the P(II) protein family
HM1_RS05035	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HM1_RS05040	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HM1_RS05045	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HM1_RS05050	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HM1_RS05055	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HM1_RS05065	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
HM1_RS05070	COG1433	Dinitrogenase iron-molybdenum cofactor
HM1_RS05070	COG0535	radical SAM domain protein
HM1_RS05075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HM1_RS05085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HM1_RS05090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HM1_RS05105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HM1_RS05110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HM1_RS05115	COG3706	GGDEF domain
HM1_RS05115	COG2203	Gaf domain
HM1_RS05115	COG5001	Diguanylate cyclase
HM1_RS05115	COG4251	negative regulation of phosphorylation
HM1_RS05135	COG0840	transmembrane signaling receptor activity
HM1_RS05140	COG3290	protein histidine kinase activity
HM1_RS05140	COG3829	transcription factor binding
HM1_RS05145	COG2376	Dihydroxyacetone kinase
HM1_RS05150	COG1461	Dihydroxyacetone kinase
HM1_RS05175	COG0489	protein tyrosine kinase activity
HM1_RS05180	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
HM1_RS05215	COG0590	tRNA wobble adenosine to inosine editing
HM1_RS05225	COG3177	Filamentation induced by cAMP protein fic
HM1_RS05245	COG0438	transferase activity, transferring glycosyl groups
HM1_RS05270	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HM1_RS05275	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HM1_RS05285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HM1_RS05285	COG1013	pyruvate-flavodoxin oxidoreductase activity
HM1_RS05285	COG0674	pyruvate-flavodoxin oxidoreductase activity
HM1_RS05285	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HM1_RS05325	COG1993	acr, cog1993
HM1_RS05330	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HM1_RS05335	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HM1_RS05360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HM1_RS05370	COG1404	Belongs to the peptidase S8 family
HM1_RS05375	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HM1_RS05415	COG0640	Transcriptional regulator
HM1_RS05420	COG0798	PFAM Bile acid sodium symporter
HM1_RS05430	COG1122	ATPase activity
HM1_RS05435	COG1122	ATPase activity
HM1_RS05440	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HM1_RS05455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HM1_RS05465	COG3443	Belongs to the bacterial solute-binding protein 9 family
HM1_RS05465	COG0803	Belongs to the bacterial solute-binding protein 9 family
HM1_RS05490	COG0741	lytic transglycosylase activity
HM1_RS05490	COG0739	heme binding
HM1_RS05490	COG1196	nuclear chromosome segregation
HM1_RS05500	COG1982	Orn Lys Arg decarboxylase major
HM1_RS05505	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HM1_RS05510	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HM1_RS05515	COG1774	PSP1 C-terminal conserved region
HM1_RS05520	COG4467	Involved in initiation control of chromosome replication
HM1_RS05525	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HM1_RS05530	COG2002	toxin-antitoxin pair type II binding
HM1_RS05540	COG0084	hydrolase, TatD family'
HM1_RS05550	COG3583	domain protein
HM1_RS05550	COG3584	3D domain protein
HM1_RS05555	COG3344	reverse transcriptase
HM1_RS05570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HM1_RS05580	COG0004	ammonium transporteR
HM1_RS05595	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HM1_RS05600	COG1802	Transcriptional regulator
HM1_RS05605	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HM1_RS05625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HM1_RS05630	COG2088	sporulation resulting in formation of a cellular spore
HM1_RS05640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HM1_RS05645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HM1_RS05655	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HM1_RS05660	COG0193	aminoacyl-tRNA hydrolase activity
HM1_RS05670	COG3437	response regulator, receiver
HM1_RS05675	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HM1_RS05680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HM1_RS05685	COG2002	toxin-antitoxin pair type II binding
HM1_RS05695	COG3956	TIGRFAM MazG family protein
HM1_RS05700	COG0776	regulation of translation
HM1_RS05705	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HM1_RS05725	COG0248	Ppx GppA phosphatase
HM1_RS05780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HM1_RS05805	COG1719	4-vinyl reductase, 4VR
HM1_RS05820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HM1_RS05830	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HM1_RS05835	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HM1_RS05840	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HM1_RS05845	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HM1_RS05855	COG1429	ligase activity, forming nitrogen-metal bonds
HM1_RS05875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HM1_RS05880	COG0105	UTP biosynthetic process
HM1_RS05885	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HM1_RS05895	COG1090	epimerase
HM1_RS05905	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HM1_RS05910	COG1418	mRNA catabolic process
HM1_RS05915	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HM1_RS05920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HM1_RS05925	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HM1_RS05930	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HM1_RS05935	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HM1_RS05940	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HM1_RS05950	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HM1_RS05950	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HM1_RS05960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HM1_RS05965	COG1335	isochorismatase
HM1_RS05970	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HM1_RS05985	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HM1_RS05990	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HM1_RS06015	COG0385	Bile acid
HM1_RS06030	COG5322	oxidoreductase activity
HM1_RS06030	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HM1_RS06035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HM1_RS06070	COG3344	reverse transcriptase
HM1_RS06090	COG0542	response to heat
HM1_RS06100	COG3880	PFAM UvrB UvrC protein
HM1_RS06105	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HM1_RS06110	COG0542	response to heat
HM1_RS06115	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HM1_RS06120	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HM1_RS06140	COG1329	Transcriptional regulator
HM1_RS06145	COG4956	integral membrane protein (PIN domain superfamily)
HM1_RS06155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HM1_RS06160	COG1045	serine acetyltransferase
HM1_RS06165	COG0215	cysteine-tRNA ligase activity
HM1_RS06170	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HM1_RS06175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HM1_RS06180	COG3688	RNA-binding protein containing a PIN domain
HM1_RS06190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HM1_RS06200	COG0250	Participates in transcription elongation, termination and antitermination
HM1_RS06205	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HM1_RS06210	COG0081	regulation of translation
HM1_RS06215	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HM1_RS06220	COG0222	ribosome binding
HM1_RS06225	COG0085	RNA polymerase activity
HM1_RS06230	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HM1_RS06235	COG1358	cellular component organization or biogenesis
HM1_RS06240	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HM1_RS06245	COG0049	tRNA binding
HM1_RS06250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HM1_RS06255	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HM1_RS06275	COG0051	transcription antitermination factor activity, RNA binding
HM1_RS06280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HM1_RS06285	COG0088	Forms part of the polypeptide exit tunnel
HM1_RS06290	COG0089	rRNA binding
HM1_RS06295	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HM1_RS06300	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HM1_RS06305	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HM1_RS06310	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HM1_RS06315	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HM1_RS06320	COG0255	Belongs to the universal ribosomal protein uL29 family
HM1_RS06325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HM1_RS06330	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HM1_RS06335	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HM1_RS06340	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HM1_RS06345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HM1_RS06350	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HM1_RS06355	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HM1_RS06360	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HM1_RS06365	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HM1_RS06370	COG1841	ribosomal large subunit assembly
HM1_RS06375	COG0200	Binds to the 23S rRNA
HM1_RS06380	COG0201	protein transport
HM1_RS06385	COG0563	adenylate kinase activity
HM1_RS06390	COG0024	Methionine aminopeptidase
HM1_RS06400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HM1_RS06405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HM1_RS06410	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HM1_RS06420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HM1_RS06425	COG0202	RNA polymerase activity
HM1_RS06430	COG0203	ribosomal protein L17
HM1_RS06435	COG1122	ATPase activity
HM1_RS06445	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HM1_RS06450	COG0101	tRNA pseudouridine synthase activity
HM1_RS06455	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HM1_RS06460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HM1_RS06465	COG0835	chemotaxis
HM1_RS06470	COG2198	Histidine kinase
HM1_RS06470	COG0643	Histidine kinase
HM1_RS06480	COG0840	transmembrane signaling receptor activity
HM1_RS06495	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HM1_RS06500	COG0459	protein refolding
HM1_RS06505	COG0860	N-Acetylmuramoyl-L-alanine amidase
HM1_RS06515	COG2078	PFAM AMMECR1 domain protein
HM1_RS06515	COG3885	ferrous iron binding
HM1_RS06530	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HM1_RS06535	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HM1_RS06540	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HM1_RS06545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HM1_RS06555	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HM1_RS06560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HM1_RS06610	COG0427	acetyl-CoA hydrolase
HM1_RS06615	COG3279	Response regulator of the LytR AlgR family
HM1_RS06625	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HM1_RS06650	COG0316	Belongs to the HesB IscA family
HM1_RS06695	COG0039	L-malate dehydrogenase activity
HM1_RS06735	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HM1_RS06750	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HM1_RS06755	COG0298	carbon dioxide binding
HM1_RS06760	COG0409	Hydrogenase expression formation protein
HM1_RS06765	COG0309	Hydrogenase expression formation protein (HypE)
HM1_RS06775	COG0693	protein deglycase activity
HM1_RS06780	COG0432	Pfam Uncharacterised protein family UPF0047
HM1_RS06785	COG0778	Nitroreductase
HM1_RS06790	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HM1_RS06810	COG1694	Mazg nucleotide pyrophosphohydrolase
HM1_RS06820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HM1_RS06820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HM1_RS06825	COG1131	(ABC) transporter
HM1_RS06830	COG0842	Transport permease protein
HM1_RS06835	COG0427	acetyl-CoA hydrolase
HM1_RS06840	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HM1_RS06845	COG1360	Flagellar Motor Protein
HM1_RS06855	COG2200	EAL domain
HM1_RS06860	COG0492	ferredoxin-NADP+ reductase activity
HM1_RS06870	COG0129	dihydroxy-acid dehydratase activity
HM1_RS06875	COG0440	acetolactate synthase activity
HM1_RS06880	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HM1_RS06885	COG0028	Belongs to the TPP enzyme family
HM1_RS06890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HM1_RS06895	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HM1_RS06900	COG0066	3-isopropylmalate dehydratase activity
HM1_RS06905	COG0473	3-isopropylmalate dehydrogenase activity
HM1_RS06910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HM1_RS06915	COG3856	small basic protein
HM1_RS06920	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HM1_RS06930	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HM1_RS06935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HM1_RS06945	COG1252	NADH dehydrogenase
HM1_RS06950	COG0583	DNA-binding transcription factor activity
HM1_RS06955	COG1773	rubredoxin
HM1_RS06955	COG1592	Rubrerythrin
HM1_RS06965	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HM1_RS06980	COG2205	protein histidine kinase activity
HM1_RS07010	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HM1_RS07015	COG1115	amino acid carrier protein
HM1_RS07020	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HM1_RS07025	COG0725	ABC transporter, periplasmic molybdate-binding protein
HM1_RS07030	COG3842	ATPase activity
HM1_RS07035	COG4149	molybdate abc transporter
HM1_RS07040	COG0861	Integral membrane protein TerC family
HM1_RS07145	COG1566	PFAM secretion protein HlyD family protein
HM1_RS07150	COG1846	Transcriptional regulator
HM1_RS07170	COG5002	protein histidine kinase activity
HM1_RS07175	COG0745	RESPONSE REGULATOR receiver
HM1_RS07195	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HM1_RS07195	COG2199	diguanylate cyclase activity
HM1_RS07205	COG0419	ATPase involved in DNA repair
HM1_RS07215	COG0728	peptidoglycan biosynthetic process
HM1_RS07220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HM1_RS07225	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HM1_RS07230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HM1_RS07235	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HM1_RS07240	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HM1_RS07250	COG0247	lactate metabolic process
HM1_RS07265	COG0126	phosphoglycerate kinase activity
HM1_RS07270	COG0149	triose-phosphate isomerase activity
HM1_RS07275	COG0148	phosphopyruvate hydratase activity
HM1_RS07300	COG0546	phosphoglycolate phosphatase activity
HM1_RS07305	COG0006	proline dipeptidase activity
HM1_RS07365	COG0778	Nitroreductase
HM1_RS07365	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HM1_RS07385	COG3344	reverse transcriptase
HM1_RS07390	COG3876	Protein conserved in bacteria
HM1_RS07395	COG3875	lactate racemase activity
HM1_RS07400	COG1691	(AIR) carboxylase
HM1_RS07410	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HM1_RS07415	COG0436	Aminotransferase
HM1_RS07420	COG1331	Highly conserved protein containing a thioredoxin domain
HM1_RS07425	COG0745	RESPONSE REGULATOR receiver
HM1_RS07430	COG2205	protein histidine kinase activity
HM1_RS07465	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HM1_RS07490	COG0840	transmembrane signaling receptor activity
HM1_RS07495	COG3344	reverse transcriptase
HM1_RS07505	COG2733	membrane
HM1_RS07510	COG2733	membrane
HM1_RS07515	COG5002	protein histidine kinase activity
HM1_RS07530	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HM1_RS07545	COG1966	Carbon starvation protein
HM1_RS07555	COG3275	phosphorelay sensor kinase activity
HM1_RS07560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HM1_RS07585	COG1606	tRNA processing
HM1_RS07600	COG1131	(ABC) transporter
HM1_RS07635	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HM1_RS07640	COG0360	Binds together with S18 to 16S ribosomal RNA
HM1_RS07650	COG2217	Heavy metal translocating P-type atpase
HM1_RS07655	COG1937	Protein conserved in bacteria
HM1_RS07660	COG2172	sigma factor antagonist activity
HM1_RS07670	COG0736	holo-[acyl-carrier-protein] synthase activity
HM1_RS07675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HM1_RS07675	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HM1_RS07680	COG0617	tRNA 3'-terminal CCA addition
HM1_RS07680	COG0517	IMP dehydrogenase activity
HM1_RS07680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HM1_RS07685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HM1_RS07690	COG0864	Transcriptional regulator
HM1_RS07695	COG2337	Toxic component of a toxin-antitoxin (TA) module
HM1_RS07700	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HM1_RS07720	COG2204	response regulator
HM1_RS07730	COG0802	atpase or kinase
HM1_RS07735	COG1214	PFAM Peptidase M22, glycoprotease
HM1_RS07740	COG0456	acetyltransferase
HM1_RS07745	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HM1_RS07745	COG0617	tRNA 3'-terminal CCA addition
HM1_RS07745	COG0517	IMP dehydrogenase activity
HM1_RS07755	COG2226	methyltransferase
HM1_RS07765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HM1_RS07770	COG0235	Class ii aldolase
HM1_RS07780	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HM1_RS07785	COG0626	cystathionine gamma-synthase activity
HM1_RS07790	COG0626	cystathionine gamma-synthase activity
HM1_RS07810	COG0437	4 iron, 4 sulfur cluster binding
HM1_RS07825	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HM1_RS07830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HM1_RS07845	COG3383	formate dehydrogenase (NAD+) activity
HM1_RS07855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HM1_RS07855	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HM1_RS07860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HM1_RS07865	COG0488	(ABC) transporter
HM1_RS07875	COG0237	dephospho-CoA kinase activity
HM1_RS07880	COG0741	lytic transglycosylase activity
HM1_RS07885	COG2323	membrane
HM1_RS07890	COG1215	transferase activity, transferring glycosyl groups
HM1_RS07900	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HM1_RS07945	COG2340	Cysteine-rich secretory protein family
HM1_RS07965	COG1842	Phage shock protein A
HM1_RS08005	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HM1_RS08015	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HM1_RS08040	COG1830	Aldolase
HM1_RS08050	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HM1_RS08055	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HM1_RS08060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HM1_RS08065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HM1_RS08070	COG0569	domain protein
HM1_RS08075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HM1_RS08080	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HM1_RS08085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HM1_RS08085	COG0072	phenylalanine-tRNA ligase activity
HM1_RS08095	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HM1_RS08095	COG1796	DNA polymerase
HM1_RS08105	COG1294	oxidase, subunit
HM1_RS08110	COG1271	oxidase subunit
HM1_RS08115	COG0826	peptidase U32
HM1_RS08120	COG1193	negative regulation of DNA recombination
HM1_RS08135	COG0745	RESPONSE REGULATOR receiver
HM1_RS08140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HM1_RS08145	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HM1_RS08200	COG0217	transcriptional regulatory protein
HM1_RS08205	COG1522	sequence-specific DNA binding
HM1_RS08215	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HM1_RS08225	COG2255	four-way junction helicase activity
HM1_RS08230	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HM1_RS08240	COG1191	sigma factor activity
HM1_RS08245	COG3693	PFAM glycoside hydrolase, family 10
HM1_RS08250	COG2385	sporulation resulting in formation of a cellular spore
HM1_RS08255	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HM1_RS08265	COG1862	Preprotein translocase
HM1_RS08280	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HM1_RS08285	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HM1_RS08290	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HM1_RS08295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HM1_RS08300	COG1490	D-aminoacyl-tRNA deacylase activity
HM1_RS08305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HM1_RS08310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HM1_RS08315	COG0124	histidyl-tRNA synthetase
HM1_RS08320	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HM1_RS08325	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HM1_RS08330	COG1937	Protein conserved in bacteria
HM1_RS08370	COG3845	ABC transporter
HM1_RS08385	COG1959	2 iron, 2 sulfur cluster binding
HM1_RS08390	COG1104	cysteine desulfurase activity
HM1_RS08395	COG0822	iron-sulfur transferase activity
HM1_RS08400	COG0482	sulfurtransferase activity
HM1_RS08415	COG0628	permease
HM1_RS08440	COG0601	transmembrane transport
HM1_RS08445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HM1_RS08460	COG0019	diaminopimelate decarboxylase activity
HM1_RS08465	COG0617	tRNA 3'-terminal CCA addition
HM1_RS08465	COG3620	sequence-specific DNA binding
HM1_RS08465	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HM1_RS08470	COG1994	Peptidase M50
HM1_RS08475	COG0180	Tryptophanyl-tRNA synthetase
HM1_RS08480	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HM1_RS08485	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HM1_RS08495	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HM1_RS08500	COG3404	Formiminotransferase-cyclodeaminase
HM1_RS08510	COG3874	Sporulation protein YtfJ
HM1_RS08515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HM1_RS08520	COG2715	membrane protein required for spore maturation
HM1_RS08525	COG0700	Nucleoside recognition
HM1_RS08535	COG1187	pseudouridine synthase activity
HM1_RS08540	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HM1_RS08555	COG2081	HI0933 family
HM1_RS08580	COG3344	reverse transcriptase
HM1_RS08590	COG5002	protein histidine kinase activity
HM1_RS08590	COG2205	protein histidine kinase activity
HM1_RS08590	COG0784	Response regulator, receiver
HM1_RS08625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HM1_RS08635	COG0135	phosphoribosylanthranilate isomerase activity
HM1_RS08640	COG0133	tryptophan synthase activity
HM1_RS08645	COG0159	tryptophan synthase activity
HM1_RS08650	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HM1_RS08660	COG0287	Prephenate dehydrogenase
HM1_RS08665	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HM1_RS08670	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HM1_RS08675	COG0204	Acyl-transferase
HM1_RS08680	COG0539	negative regulation of cytoplasmic translation
HM1_RS08680	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HM1_RS08705	COG4492	Belongs to the UPF0735 family
HM1_RS08710	COG0460	homoserine dehydrogenase
HM1_RS08715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HM1_RS08720	COG0083	homoserine kinase activity
HM1_RS08750	COG2226	methyltransferase
HM1_RS08755	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HM1_RS08760	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HM1_RS08765	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HM1_RS08770	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HM1_RS08775	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HM1_RS08780	COG0805	protein transport
HM1_RS08790	COG1776	CheC inhibitor of MCP methylation
HM1_RS08795	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HM1_RS08810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HM1_RS08815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HM1_RS08825	COG1333	cytochrome c biogenesis protein
HM1_RS08830	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HM1_RS08835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HM1_RS08835	COG1648	precorrin-2 dehydrogenase activity
HM1_RS08845	COG0181	hydroxymethylbilane synthase activity
HM1_RS08855	COG0535	radical SAM domain protein
HM1_RS08860	COG0113	porphobilinogen synthase activity
HM1_RS08865	COG0535	radical SAM domain protein
HM1_RS08870	COG1522	sequence-specific DNA binding
HM1_RS08875	COG1522	sequence-specific DNA binding
HM1_RS08880	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HM1_RS08905	COG0028	Belongs to the TPP enzyme family
HM1_RS08910	COG0440	acetolactate synthase activity
HM1_RS08915	COG1304	FMN binding
HM1_RS08935	COG1160	GTP binding
HM1_RS08940	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HM1_RS08945	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HM1_RS08950	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HM1_RS08955	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HM1_RS08960	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HM1_RS08965	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HM1_RS08970	COG0358	DNA primase activity
HM1_RS08975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HM1_RS08985	COG2384	SAM-dependent methyltransferase
HM1_RS08990	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HM1_RS09020	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HM1_RS09025	COG1763	Mo-molybdopterin cofactor biosynthetic process
HM1_RS09040	COG1233	COG1233 Phytoene dehydrogenase and related
HM1_RS09080	COG1401	restriction endodeoxyribonuclease activity
HM1_RS09085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HM1_RS09090	COG0745	RESPONSE REGULATOR receiver
HM1_RS09125	COG2201	protein-glutamate methylesterase activity
HM1_RS09140	COG2022	thiamine diphosphate biosynthetic process
HM1_RS09150	COG1131	(ABC) transporter
HM1_RS09155	COG0842	Transport permease protein
HM1_RS09160	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HM1_RS09175	COG2362	D-Aminopeptidase
HM1_RS09180	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HM1_RS09185	COG0438	transferase activity, transferring glycosyl groups
HM1_RS09200	COG0735	belongs to the Fur family
HM1_RS09215	COG2234	aminopeptidase activity
HM1_RS09220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HM1_RS09225	COG0163	prenyltransferase activity
HM1_RS09230	COG2001	Belongs to the MraZ family
HM1_RS09235	COG0275	rRNA processing
HM1_RS09245	COG0768	penicillin binding
HM1_RS09250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HM1_RS09255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HM1_RS09260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HM1_RS09265	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HM1_RS09270	COG0772	Belongs to the SEDS family
HM1_RS09275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HM1_RS09280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HM1_RS09285	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HM1_RS09290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HM1_RS09300	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HM1_RS09310	COG1191	sigma factor activity
HM1_RS09315	COG1191	sigma factor activity
HM1_RS09320	COG1873	PFAM PRC-barrel domain
HM1_RS09325	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HM1_RS09330	COG1328	CTP reductase activity
HM1_RS09345	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HM1_RS09350	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HM1_RS09355	COG2738	Putative neutral zinc metallopeptidase
HM1_RS09360	COG0602	queuosine metabolic process
HM1_RS09365	COG1496	oxidoreductase activity
HM1_RS09370	COG0745	RESPONSE REGULATOR receiver
HM1_RS09375	COG5002	protein histidine kinase activity
HM1_RS09385	COG2200	EAL domain
HM1_RS09390	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HM1_RS09395	COG0573	inorganic phosphate transmembrane transporter activity
HM1_RS09400	COG0581	inorganic phosphate transmembrane transporter activity
HM1_RS09410	COG0704	Plays a role in the regulation of phosphate uptake
HM1_RS09415	COG2233	PERMEase
HM1_RS09425	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HM1_RS09430	COG1799	cell septum assembly
HM1_RS09435	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HM1_RS09440	COG0762	integral membrane protein
HM1_RS09455	COG1872	DUF167
HM1_RS09460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HM1_RS09465	COG4869	propanediol catabolic process
HM1_RS09475	COG2848	UPF0210 protein
HM1_RS09495	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HM1_RS09500	COG0564	pseudouridine synthase activity
HM1_RS09505	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HM1_RS09510	COG0540	Belongs to the ATCase OTCase family
HM1_RS09515	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HM1_RS09520	COG0505	Belongs to the CarA family
HM1_RS09525	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HM1_RS09530	COG0543	2 iron, 2 sulfur cluster binding
HM1_RS09535	COG0167	dihydroorotate dehydrogenase activity
HM1_RS09555	COG0840	transmembrane signaling receptor activity
HM1_RS09560	COG0840	transmembrane signaling receptor activity
HM1_RS09575	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HM1_RS09580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HM1_RS09585	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HM1_RS09590	COG1561	YicC-like family, N-terminal region
HM1_RS09600	COG2052	Domain of unknown function (DUF370)
HM1_RS09605	COG0194	GDP metabolic process
HM1_RS09610	COG1758	RNA polymerase activity
HM1_RS09615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HM1_RS09625	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HM1_RS09630	COG0242	peptide deformylase activity
HM1_RS09635	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HM1_RS09645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HM1_RS09645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HM1_RS09650	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HM1_RS09660	COG0515	serine threonine protein kinase
HM1_RS09660	COG2815	serine threonine protein kinase
HM1_RS09665	COG1162	GTPase activity
HM1_RS09670	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HM1_RS09675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HM1_RS09675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HM1_RS09685	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HM1_RS09685	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HM1_RS09690	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HM1_RS09695	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HM1_RS09700	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HM1_RS09710	COG1302	Protein conserved in bacteria
HM1_RS09715	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HM1_RS09725	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HM1_RS09730	COG0742	ribosomal rna small subunit methyltransferase
HM1_RS09735	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HM1_RS09750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HM1_RS09760	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HM1_RS09770	COG0416	fatty acid biosynthetic process
HM1_RS09780	COG2070	2-Nitropropane dioxygenase
HM1_RS09785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HM1_RS09790	COG1028	Short-chain dehydrogenase reductase Sdr
HM1_RS09795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM1_RS09800	COG2070	2-Nitropropane dioxygenase
HM1_RS09805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HM1_RS09810	COG0571	ribonuclease III activity
HM1_RS09825	COG2359	stage V sporulation protein S
HM1_RS09830	COG1196	nuclear chromosome segregation
HM1_RS09835	COG0552	protein localization to endoplasmic reticulum
HM1_RS09845	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HM1_RS09850	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HM1_RS09855	COG0402	S-adenosylhomocysteine deaminase activity
HM1_RS09865	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HM1_RS09870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HM1_RS09875	COG0228	four-way junction DNA binding
HM1_RS09885	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HM1_RS09890	COG0336	Belongs to the RNA methyltransferase TrmD family
HM1_RS09895	COG4752	Belongs to the RNA methyltransferase TrmD family
HM1_RS09900	COG0335	large ribosomal subunit rRNA binding
HM1_RS09905	COG0681	Belongs to the peptidase S26 family
HM1_RS09910	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HM1_RS09920	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HM1_RS09930	COG2257	FlhB HrpN YscU SpaS Family
HM1_RS09935	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HM1_RS09940	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HM1_RS09945	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HM1_RS09950	COG0649	NAD binding
HM1_RS09955	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HM1_RS09960	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HM1_RS09975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HM1_RS09980	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HM1_RS09985	COG1007	ATP synthesis coupled electron transport
HM1_RS09990	COG0792	nuclease activity
HM1_RS10000	COG0758	DNA mediated transformation
HM1_RS10005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HM1_RS10010	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HM1_RS10015	COG4974	Belongs to the 'phage' integrase family
HM1_RS10020	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HM1_RS10025	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HM1_RS10035	COG1815	bacterial-type flagellum-dependent cell motility
HM1_RS10045	COG1677	Flagellar hook-basal body complex protein FliE
HM1_RS10055	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HM1_RS10065	COG1157	protein secretion by the type III secretion system
HM1_RS10100	COG1582	Flagellar protein (FlbD)
HM1_RS10110	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HM1_RS10115	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HM1_RS10115	COG1776	CheC inhibitor of MCP methylation
HM1_RS10125	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HM1_RS10125	COG1776	CheC inhibitor of MCP methylation
HM1_RS10130	COG2201	protein-glutamate methylesterase activity
HM1_RS10140	COG1338	Plays a role in the flagellum-specific transport system
HM1_RS10145	COG1987	bacterial-type flagellum assembly
HM1_RS10155	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HM1_RS10160	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HM1_RS10165	COG1419	protein localization to endoplasmic reticulum
HM1_RS10170	COG0455	bacterial-type flagellum organization
HM1_RS10175	COG2201	protein-glutamate methylesterase activity
HM1_RS10180	COG0643	Histidine kinase
HM1_RS10180	COG2198	Histidine kinase
HM1_RS10200	COG1191	sigma factor activity
HM1_RS10225	COG0052	Belongs to the universal ribosomal protein uS2 family
HM1_RS10230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HM1_RS10235	COG0528	UMP kinase activity
HM1_RS10240	COG0233	cytoplasmic translational termination
HM1_RS10255	COG4589	Belongs to the CDS family
HM1_RS10260	COG0628	permease
HM1_RS10265	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HM1_RS10270	COG0750	zinc metalloprotease
HM1_RS10275	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HM1_RS10280	COG0442	prolyl-tRNA aminoacylation
HM1_RS10295	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HM1_RS10300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HM1_RS10325	COG1176	ABC-type spermidine putrescine transport system, permease component I
HM1_RS10330	COG1177	transmembrane transport
HM1_RS10335	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HM1_RS10480	COG0779	Required for maturation of 30S ribosomal subunits
HM1_RS10485	COG0195	Participates in both transcription termination and antitermination
HM1_RS10490	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HM1_RS10500	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HM1_RS10500	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HM1_RS10505	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HM1_RS10515	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HM1_RS10520	COG0196	riboflavin kinase activity
HM1_RS10535	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HM1_RS10540	COG1185	polyribonucleotide nucleotidyltransferase activity
HM1_RS10550	COG1686	Belongs to the peptidase S11 family
HM1_RS10555	COG0612	Peptidase, M16
HM1_RS10560	COG1873	PFAM PRC-barrel domain
HM1_RS10570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HM1_RS10575	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HM1_RS10580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HM1_RS10585	COG0527	aspartate kinase activity
HM1_RS10590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HM1_RS10595	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HM1_RS10600	COG0740	serine-type endopeptidase activity
HM1_RS10610	COG1674	ftsk spoiiie
HM1_RS10610	COG4980	gas vesicle protein
HM1_RS10620	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HM1_RS10625	COG1426	Protein conserved in bacteria
HM1_RS10630	COG1666	GTP binding
HM1_RS10640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HM1_RS10645	COG2957	Belongs to the agmatine deiminase family
HM1_RS10715	COG1793	dna ligase
HM1_RS10715	COG3285	dna ligase
HM1_RS10720	COG1793	dna ligase
HM1_RS10730	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HM1_RS10735	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HM1_RS10745	COG1268	BioY protein
HM1_RS10750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HM1_RS10755	COG2186	Transcriptional regulator
HM1_RS10765	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HM1_RS10800	COG0726	polysaccharide deacetylase
HM1_RS10815	COG0454	-acetyltransferase
HM1_RS10820	COG0517	IMP dehydrogenase activity
HM1_RS10825	COG0123	including yeast histone deacetylase and acetoin utilization protein
HM1_RS10835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HM1_RS10840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HM1_RS10850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HM1_RS10855	COG1546	Belongs to the CinA family
HM1_RS10855	COG1058	Belongs to the CinA family
HM1_RS10860	COG0513	Belongs to the DEAD box helicase family
HM1_RS10875	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HM1_RS10885	COG1418	mRNA catabolic process
HM1_RS10895	COG1692	metallophosphoesterase
HM1_RS10900	COG2359	stage V sporulation protein S
HM1_RS10910	COG0436	Aminotransferase
HM1_RS10920	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HM1_RS10975	COG1492	cobalamin metabolic process
HM1_RS10980	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HM1_RS10985	COG1797	cobyrinic acid a,c-diamide synthase activity
HM1_RS10990	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HM1_RS10995	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HM1_RS11010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HM1_RS11015	COG0406	alpha-ribazole phosphatase activity
HM1_RS11025	COG0517	IMP dehydrogenase activity
HM1_RS11025	COG0516	GMP reductase activity
HM1_RS11035	COG0561	phosphatase activity
HM1_RS11050	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HM1_RS11060	COG1217	gtp-binding protein TYPA
HM1_RS11065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HM1_RS11070	COG1869	D-ribose catabolic process
HM1_RS11075	COG1129	ABC transporter
HM1_RS11080	COG1172	Belongs to the binding-protein-dependent transport system permease family
HM1_RS11085	COG1879	ABC-type sugar transport system periplasmic component
HM1_RS11090	COG1121	(ABC) transporter
HM1_RS11095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HM1_RS11100	COG0735	belongs to the Fur family
HM1_RS11110	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HM1_RS11120	COG0268	Binds directly to 16S ribosomal RNA
HM1_RS11135	COG0728	peptidoglycan biosynthetic process
HM1_RS11140	COG0481	GTPase activity
HM1_RS11145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HM1_RS11150	COG1420	regulation of RNA biosynthetic process
HM1_RS11155	COG0459	protein refolding
HM1_RS11160	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HM1_RS11165	COG0443	Heat shock 70 kDa protein
HM1_RS11170	COG0484	heat shock protein binding
HM1_RS11175	COG2264	protein methyltransferase activity
HM1_RS11180	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HM1_RS11185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HM1_RS11190	COG0537	adenosine 5'-monophosphoramidase activity
HM1_RS11195	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HM1_RS11200	COG1610	YqeY-like protein
HM1_RS11215	COG1702	phosphate starvation-inducible protein PhoH
HM1_RS11220	COG1480	7TM receptor with intracellular HD hydrolase
HM1_RS11225	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HM1_RS11230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HM1_RS11240	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HM1_RS11245	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HM1_RS11250	COG1381	Involved in DNA repair and RecF pathway recombination
HM1_RS11265	COG0752	glycyl-tRNA synthetase alpha subunit
HM1_RS11270	COG0751	glycine-tRNA ligase activity
HM1_RS11275	COG0517	IMP dehydrogenase activity
HM1_RS11280	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HM1_RS11285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HM1_RS11285	COG0574	Belongs to the PEP-utilizing enzyme family
HM1_RS11290	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HM1_RS11315	COG0849	cell division
HM1_RS11325	COG0756	dUTP diphosphatase activity
HM1_RS11330	COG2088	sporulation resulting in formation of a cellular spore
HM1_RS11335	COG2088	sporulation resulting in formation of a cellular spore
HM1_RS11345	COG0662	Cupin 2, conserved barrel domain protein
HM1_RS11370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HM1_RS11380	COG1376	ErfK ybiS ycfS ynhG family protein
HM1_RS11410	COG0646	methionine synthase
HM1_RS11410	COG1410	methionine synthase
HM1_RS11425	COG1522	sequence-specific DNA binding
HM1_RS11430	COG0436	Aminotransferase
HM1_RS11435	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HM1_RS11440	COG2221	Nitrite and sulphite reductase 4Fe-4S
HM1_RS11450	COG1921	L-seryl-tRNASec selenium transferase activity
HM1_RS11455	COG0709	Synthesizes selenophosphate from selenide and ATP
HM1_RS11460	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HM1_RS11465	COG3773	Cell wall hydrolase
HM1_RS11465	COG3409	Peptidoglycan-binding domain 1 protein
HM1_RS11475	COG3409	Peptidoglycan-binding domain 1 protein
HM1_RS11475	COG3773	Cell wall hydrolase
HM1_RS11480	COG2959	enzyme of heme biosynthesis
HM1_RS11485	COG4869	propanediol catabolic process
HM1_RS11495	COG3279	Response regulator of the LytR AlgR family
HM1_RS11555	COG0840	transmembrane signaling receptor activity
HM1_RS11565	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HM1_RS11565	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HM1_RS11570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HM1_RS11580	COG1361	Conserved repeat domain
HM1_RS11580	COG2911	Protein conserved in bacteria
HM1_RS11580	COG3266	domain, Protein
HM1_RS11590	COG1316	TRANSCRIPTIONal
HM1_RS11595	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HM1_RS11600	COG0560	Phosphoserine phosphatase
HM1_RS11600	COG3830	Belongs to the UPF0237 family
HM1_RS11610	COG1183	phosphatidylcholine synthase activity
HM1_RS11635	COG0735	belongs to the Fur family
HM1_RS11640	COG3344	reverse transcriptase
HM1_RS11650	COG0602	queuosine metabolic process
HM1_RS11655	COG0302	gtp cyclohydrolase
HM1_RS11665	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HM1_RS11675	COG2244	polysaccharide biosynthetic process
HM1_RS11680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HM1_RS11685	COG0613	PHP domain protein
HM1_RS11690	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HM1_RS11700	COG1615	UPF0182 protein
HM1_RS11720	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HM1_RS11725	COG1181	Belongs to the D-alanine--D-alanine ligase family
HM1_RS11735	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HM1_RS11740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HM1_RS11745	COG3344	reverse transcriptase
HM1_RS11750	COG0464	growth
HM1_RS11765	COG1923	regulation of RNA biosynthetic process
HM1_RS11770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HM1_RS11775	COG2136	Putative SAM-dependent methyltransferase
HM1_RS11775	COG2521	methyltransferase
HM1_RS11780	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HM1_RS11785	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HM1_RS11790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HM1_RS11795	COG5002	protein histidine kinase activity
HM1_RS11840	COG3344	reverse transcriptase
HM1_RS11845	COG0785	Cytochrome C biogenesis protein
HM1_RS11855	COG1404	Belongs to the peptidase S8 family
HM1_RS11860	COG0598	Magnesium transport protein CorA
HM1_RS11870	COG0840	transmembrane signaling receptor activity
HM1_RS11885	COG0189	ligase activity
HM1_RS11890	COG0189	ligase activity
HM1_RS11900	COG1366	Belongs to the anti-sigma-factor antagonist family
HM1_RS11905	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HM1_RS11910	COG3344	reverse transcriptase
HM1_RS11915	COG0277	FAD linked oxidase domain protein
HM1_RS11920	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HM1_RS11925	COG2086	electron transfer activity
HM1_RS11930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HM1_RS11940	COG0531	amino acid
HM1_RS11960	COG0643	Histidine kinase
HM1_RS11960	COG2198	Histidine kinase
HM1_RS11960	COG0784	Response regulator, receiver
HM1_RS11965	COG2201	protein-glutamate methylesterase activity
HM1_RS11990	COG1012	belongs to the aldehyde dehydrogenase family
HM1_RS11990	COG1454	alcohol dehydrogenase
HM1_RS11995	COG3437	response regulator, receiver
HM1_RS11995	COG3850	Histidine kinase
HM1_RS11995	COG4999	Histidine kinase
HM1_RS11995	COG2205	protein histidine kinase activity
HM1_RS12015	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HM1_RS12015	COG3608	succinylglutamate desuccinylase aspartoacylase
HM1_RS12020	COG3608	succinylglutamate desuccinylase aspartoacylase
HM1_RS12020	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HM1_RS12030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HM1_RS12040	COG0549	Belongs to the carbamate kinase family
HM1_RS12045	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HM1_RS12050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HM1_RS12055	COG2080	2 iron, 2 sulfur cluster binding
HM1_RS12060	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HM1_RS12065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HM1_RS12075	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HM1_RS12075	COG0493	'glutamate synthase
HM1_RS12080	COG0402	S-adenosylhomocysteine deaminase activity
HM1_RS12090	COG1584	GPR1 FUN34 yaaH family protein
HM1_RS12100	COG0488	(ABC) transporter
HM1_RS12110	COG3344	reverse transcriptase
HM1_RS12135	COG3279	Response regulator of the LytR AlgR family
HM1_RS12140	COG3275	phosphorelay sensor kinase activity
HM1_RS12145	COG2610	gluconate transmembrane transporter activity
HM1_RS12150	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HM1_RS12155	COG3395	kinase activity
HM1_RS12160	COG1349	DNA-binding transcription factor activity
HM1_RS12170	COG0303	'Molybdopterin
HM1_RS12175	COG1910	domain protein
HM1_RS12180	COG0495	leucyl-tRNA aminoacylation
HM1_RS12190	COG0586	Pfam SNARE associated Golgi protein
HM1_RS12195	COG2226	methyltransferase
HM1_RS12205	COG1846	Transcriptional regulator
HM1_RS12205	COG1940	carbohydrate kinase activity
HM1_RS12215	COG1132	(ABC) transporter
HM1_RS12230	COG0402	S-adenosylhomocysteine deaminase activity
HM1_RS12235	COG1079	Belongs to the binding-protein-dependent transport system permease family
HM1_RS12245	COG3845	ABC transporter
HM1_RS12260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HM1_RS12270	COG0799	negative regulation of ribosome biogenesis
HM1_RS12275	COG1713	HD superfamily hydrolase involved in NAD metabolism
HM1_RS12280	COG0724	RNA recognition motif
HM1_RS12285	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HM1_RS12290	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HM1_RS12295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HM1_RS12300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HM1_RS12310	COG3344	reverse transcriptase
HM1_RS12315	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HM1_RS12320	COG2868	ribosomal protein
HM1_RS12325	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HM1_RS12330	COG1530	ribonuclease E activity
HM1_RS12355	COG0531	amino acid
HM1_RS12370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HM1_RS12380	COG0772	Belongs to the SEDS family
HM1_RS12385	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HM1_RS12390	COG2894	cell division
HM1_RS12395	COG0850	regulation of cytokinetic process
HM1_RS12415	COG1077	Cell shape determining protein MreB Mrl
HM1_RS12420	COG2003	Belongs to the UPF0758 family
HM1_RS12425	COG0424	maF-like protein
HM1_RS12440	COG5012	cobalamin binding
HM1_RS12455	COG3069	C4-dicarboxylate transmembrane transporter activity
HM1_RS12485	COG0306	phosphate transporter
HM1_RS12495	COG0285	dihydrofolate synthase activity
HM1_RS12500	COG0525	valine-tRNA ligase activity
HM1_RS12505	COG1703	isobutyryl-CoA mutase activity
HM1_RS12515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HM1_RS12520	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HM1_RS12530	COG0039	L-malate dehydrogenase activity
HM1_RS12535	COG0861	Integral membrane protein TerC family
HM1_RS12555	COG1013	pyruvate-flavodoxin oxidoreductase activity
HM1_RS12565	COG0674	pyruvate-flavodoxin oxidoreductase activity
HM1_RS12565	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HM1_RS12585	COG5298	Protein conserved in bacteria
HM1_RS12605	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HM1_RS12610	COG0688	phosphatidylethanolamine metabolic process
HM1_RS12620	COG1785	Belongs to the alkaline phosphatase family
HM1_RS12650	COG3383	formate dehydrogenase (NAD+) activity
HM1_RS12655	COG0840	transmembrane signaling receptor activity
HM1_RS12680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HM1_RS12690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HM1_RS12695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HM1_RS12705	COG4224	UPF0291 protein
HM1_RS12735	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HM1_RS12735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HM1_RS12760	COG0328	RNA-DNA hybrid ribonuclease activity
HM1_RS12775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HM1_RS12780	COG0745	RESPONSE REGULATOR receiver
HM1_RS12830	COG0842	Transport permease protein
HM1_RS12970	COG1595	DNA-templated transcription, initiation
HM1_RS13000	COG1404	Belongs to the peptidase S8 family
HM1_RS13005	COG0464	growth
HM1_RS13015	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HM1_RS13035	COG3584	3D domain protein
HM1_RS13035	COG1388	LysM domain
HM1_RS13115	COG0740	serine-type endopeptidase activity
HM1_RS13120	COG4695	Portal protein
HM1_RS13125	COG1802	Transcriptional regulator
HM1_RS13125	COG4626	Terminase
HM1_RS13270	COG1595	DNA-templated transcription, initiation
HM1_RS13355	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HM1_RS13355	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HM1_RS13405	COG1475	DNA binding
HM1_RS13440	COG4974	Belongs to the 'phage' integrase family
HM1_RS13445	COG4974	Belongs to the 'phage' integrase family
HM1_RS13465	COG4626	Terminase
HM1_RS13465	COG1802	Transcriptional regulator
HM1_RS13470	COG4695	Portal protein
HM1_RS13475	COG0740	serine-type endopeptidase activity
HM1_RS13540	COG3858	chitin binding
HM1_RS13590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HM1_RS13600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HM1_RS13620	COG1543	Belongs to the glycosyl hydrolase 57 family
HM1_RS13635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HM1_RS13645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HM1_RS13650	COG1074	ATP-dependent DNA helicase activity
HM1_RS13655	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HM1_RS13660	COG3481	metal-dependent phosphohydrolase, HD sub domain
HM1_RS13670	COG1122	ATPase activity
HM1_RS13680	COG0310	cobalt ion transport
HM1_RS13700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HM1_RS13730	COG0640	Transcriptional regulator
HM1_RS13755	COG1489	DNA binding
HM1_RS13760	COG0840	transmembrane signaling receptor activity
HM1_RS13765	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HM1_RS13770	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HM1_RS13775	COG0154	amidase activity
HM1_RS13780	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HM1_RS13790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HM1_RS13815	COG2814	Major facilitator Superfamily
HM1_RS13820	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HM1_RS13825	COG1242	4 iron, 4 sulfur cluster binding
HM1_RS13840	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HM1_RS13850	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HM1_RS13850	COG0140	phosphoribosyl-ATP diphosphatase activity
HM1_RS13855	COG0107	imidazoleglycerol-phosphate synthase activity
HM1_RS13860	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HM1_RS13865	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HM1_RS13870	COG0131	Imidazoleglycerol-phosphate dehydratase
HM1_RS13890	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HM1_RS13895	COG4496	protein, YerC YecD
HM1_RS13910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HM1_RS13915	COG1388	LysM domain
HM1_RS13915	COG0791	NLP P60 protein
HM1_RS13920	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HM1_RS13940	COG3290	protein histidine kinase activity
HM1_RS13940	COG0840	transmembrane signaling receptor activity
HM1_RS13965	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HM1_RS13980	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HM1_RS14015	COG1846	Transcriptional regulator
HM1_RS14050	COG2814	Major facilitator Superfamily
HM1_RS14055	COG5001	Diguanylate cyclase
HM1_RS14055	COG5002	protein histidine kinase activity
HM1_RS14065	COG1136	(ABC) transporter
HM1_RS14065	COG0577	efflux transmembrane transporter activity
HM1_RS14070	COG1136	(ABC) transporter
HM1_RS14085	COG3344	reverse transcriptase
HM1_RS14090	COG0860	N-Acetylmuramoyl-L-alanine amidase
HM1_RS14100	COG0517	IMP dehydrogenase activity
HM1_RS14105	COG0151	Belongs to the GarS family
HM1_RS14110	COG0138	bifunctional purine biosynthesis protein purh
HM1_RS14115	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HM1_RS14120	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HM1_RS14125	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HM1_RS14135	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HM1_RS14140	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HM1_RS14145	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HM1_RS14150	COG2252	PERMEase
HM1_RS14170	COG0697	spore germination
HM1_RS14185	COG2088	sporulation resulting in formation of a cellular spore
HM1_RS14200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HM1_RS14210	COG1396	sequence-specific DNA binding
HM1_RS14225	COG0352	thiamine-phosphate diphosphorylase activity
HM1_RS14240	COG3693	PFAM glycoside hydrolase, family 10
HM1_RS14245	COG3693	PFAM glycoside hydrolase, family 10
HM1_RS14255	COG3693	PFAM glycoside hydrolase, family 10
HM1_RS14260	COG0732	type I restriction modification DNA specificity domain
HM1_RS14270	COG0840	transmembrane signaling receptor activity
HM1_RS14290	COG0840	transmembrane signaling receptor activity
HM1_RS14320	COG2204	response regulator
HM1_RS14325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM1_RS14330	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HM1_RS14335	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HM1_RS14360	COG2720	vancomycin resistance protein
HM1_RS14395	COG4786	Flagellar basal body rod
HM1_RS14395	COG1256	bacterial-type flagellum assembly
HM1_RS14405	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HM1_RS14415	COG0438	transferase activity, transferring glycosyl groups
HM1_RS14420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HM1_RS14435	COG3852	Histidine kinase
HM1_RS14460	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HM1_RS14465	COG0739	heme binding
HM1_RS14475	COG0784	Response regulator, receiver
HM1_RS14475	COG3437	response regulator, receiver
HM1_RS14480	COG4999	Histidine kinase
HM1_RS14480	COG3437	response regulator, receiver
HM1_RS14480	COG3850	Histidine kinase
HM1_RS14480	COG2205	protein histidine kinase activity
HM1_RS14485	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HM1_RS14500	COG1388	LysM domain
HM1_RS14500	COG3584	3D domain protein
HM1_RS14515	COG2244	polysaccharide biosynthetic process
HM1_RS14555	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HM1_RS14595	COG3852	Histidine kinase
HM1_RS14605	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HM1_RS14610	COG3279	Response regulator of the LytR AlgR family
HM1_RS14640	COG5002	protein histidine kinase activity
HM1_RS14640	COG3850	Histidine kinase
HM1_RS14645	COG0632	four-way junction helicase activity
HM1_RS14660	COG3858	chitin binding
HM1_RS14665	COG0793	Belongs to the peptidase S41A family
HM1_RS14685	COG2302	S4 RNA-binding domain
HM1_RS14705	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HM1_RS14725	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HM1_RS14735	COG1388	LysM domain
HM1_RS14735	COG3584	3D domain protein
HM1_RS14745	COG0726	polysaccharide deacetylase
HM1_RS14755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HM1_RS14760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HM1_RS14765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HM1_RS14785	COG3942	CHAP domain
HM1_RS14785	COG1388	LysM domain
HM1_RS14790	COG0598	Magnesium transport protein CorA
HM1_RS14795	COG5002	protein histidine kinase activity
HM1_RS14795	COG5002	protein histidine kinase activity
HM1_RS14850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family