locus-tag	class	description
E2K99_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E2K99_RS00025	COG0537	adenosine 5'-monophosphoramidase activity
E2K99_RS00045	COG5001	Diguanylate cyclase
E2K99_RS00045	COG3300	MHYT domain
E2K99_RS00070	COG2733	membrane
E2K99_RS00075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E2K99_RS00110	COG0840	transmembrane signaling receptor activity
E2K99_RS00115	COG0430	RNA-3'-phosphate cyclase activity
E2K99_RS00120	COG1690	Belongs to the RtcB family
E2K99_RS00130	COG4650	regulator
E2K99_RS00135	COG3541	Predicted nucleotidyltransferase
E2K99_RS00150	COG2814	Major facilitator Superfamily
E2K99_RS00165	COG0840	transmembrane signaling receptor activity
E2K99_RS00175	COG0427	acetyl-CoA hydrolase
E2K99_RS00180	COG0583	DNA-binding transcription factor activity
E2K99_RS00215	COG0505	Belongs to the CarA family
E2K99_RS00220	COG0583	DNA-binding transcription factor activity
E2K99_RS00225	COG1063	alcohol dehydrogenase
E2K99_RS00235	COG2814	Major facilitator Superfamily
E2K99_RS00240	COG0583	DNA-binding transcription factor activity
E2K99_RS00270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E2K99_RS00280	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E2K99_RS00285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2K99_RS00300	COG3158	transport of potassium into the cell
E2K99_RS00305	COG1522	sequence-specific DNA binding
E2K99_RS00310	COG2423	ornithine cyclodeaminase activity
E2K99_RS00325	COG0765	amino acid transport
E2K99_RS00360	COG5000	phosphorelay sensor kinase activity
E2K99_RS00370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E2K99_RS00370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E2K99_RS00385	COG1297	OPT oligopeptide transporter protein
E2K99_RS00390	COG4589	Belongs to the CDS family
E2K99_RS00405	COG2267	carboxylic ester hydrolase activity
E2K99_RS00410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E2K99_RS00415	COG1280	lysine exporter protein (LysE YggA)
E2K99_RS00420	COG0606	chelatase, subunit chli
E2K99_RS00500	COG1815	bacterial-type flagellum-dependent cell motility
E2K99_RS00515	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2K99_RS00520	COG0745	RESPONSE REGULATOR receiver
E2K99_RS00585	COG2194	sulfuric ester hydrolase activity
E2K99_RS00615	COG0606	chelatase, subunit chli
E2K99_RS00630	COG0347	Belongs to the P(II) protein family
E2K99_RS00635	COG0004	ammonium transporteR
E2K99_RS00645	COG0189	ligase activity
E2K99_RS00655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E2K99_RS00660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E2K99_RS00665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E2K99_RS00675	COG2814	Major facilitator Superfamily
E2K99_RS00695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E2K99_RS00715	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E2K99_RS00720	COG0081	regulation of translation
E2K99_RS00725	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E2K99_RS00730	COG0222	ribosome binding
E2K99_RS00735	COG0085	RNA polymerase activity
E2K99_RS00740	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E2K99_RS00750	COG3720	iron ion transport
E2K99_RS00755	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E2K99_RS00760	COG0049	tRNA binding
E2K99_RS00765	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E2K99_RS00770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E2K99_RS00775	COG0051	transcription antitermination factor activity, RNA binding
E2K99_RS00780	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E2K99_RS00785	COG0088	Forms part of the polypeptide exit tunnel
E2K99_RS00790	COG0089	rRNA binding
E2K99_RS00795	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E2K99_RS00800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E2K99_RS00805	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E2K99_RS00810	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E2K99_RS00815	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E2K99_RS00820	COG0255	Belongs to the universal ribosomal protein uL29 family
E2K99_RS00825	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E2K99_RS00830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E2K99_RS00835	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E2K99_RS00840	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E2K99_RS00845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E2K99_RS00850	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E2K99_RS00855	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E2K99_RS00860	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E2K99_RS00865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E2K99_RS00870	COG1841	ribosomal large subunit assembly
E2K99_RS00875	COG0200	Binds to the 23S rRNA
E2K99_RS00880	COG0201	protein transport
E2K99_RS00885	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E2K99_RS00890	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E2K99_RS00895	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E2K99_RS00900	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E2K99_RS00905	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E2K99_RS00910	COG0202	RNA polymerase activity
E2K99_RS00915	COG0203	ribosomal protein L17
E2K99_RS00920	COG1324	tolerance protein
E2K99_RS00925	COG4232	protein-disulfide reductase activity
E2K99_RS00930	COG0450	alkyl hydroperoxide reductase
E2K99_RS00980	COG0583	DNA-binding transcription factor activity
E2K99_RS00985	COG1454	alcohol dehydrogenase
E2K99_RS00990	COG1012	belongs to the aldehyde dehydrogenase family
E2K99_RS01000	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E2K99_RS01005	COG1595	DNA-templated transcription, initiation
E2K99_RS01015	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E2K99_RS01025	COG1333	cytochrome c biogenesis protein
E2K99_RS01030	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E2K99_RS01035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E2K99_RS01050	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E2K99_RS01060	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E2K99_RS01070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E2K99_RS01075	COG0588	phosphoglycerate mutase activity
E2K99_RS01080	COG4942	peptidase
E2K99_RS01085	COG0793	Belongs to the peptidase S41A family
E2K99_RS01090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E2K99_RS01105	COG4206	TonB-dependent receptor
E2K99_RS01115	COG1917	Cupin 2, conserved barrel domain protein
E2K99_RS01115	COG4977	sequence-specific DNA binding
E2K99_RS01145	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2K99_RS01175	COG3179	chitinase
E2K99_RS01185	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E2K99_RS01185	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E2K99_RS01185	COG0506	proline dehydrogenase activity
E2K99_RS01190	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E2K99_RS01195	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E2K99_RS01205	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2K99_RS01215	COG2165	general secretion pathway protein
E2K99_RS01220	COG1965	Belongs to the frataxin family
E2K99_RS01250	COG3387	PFAM Glycoside hydrolase 15-related
E2K99_RS01255	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E2K99_RS01270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E2K99_RS01280	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E2K99_RS01290	COG0494	nUDIX hydrolase
E2K99_RS01295	COG3568	Endonuclease Exonuclease Phosphatase
E2K99_RS01300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2K99_RS01305	COG0183	Belongs to the thiolase family
E2K99_RS01340	COG1960	acyl-CoA dehydrogenase activity
E2K99_RS01345	COG1024	Enoyl-CoA hydratase
E2K99_RS01345	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2K99_RS01350	COG0183	Belongs to the thiolase family
E2K99_RS01355	COG1024	Enoyl-CoA hydratase
E2K99_RS01360	COG1522	sequence-specific DNA binding
E2K99_RS01365	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E2K99_RS01385	COG3300	MHYT domain
E2K99_RS01385	COG5001	Diguanylate cyclase
E2K99_RS01405	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E2K99_RS01415	COG5001	Diguanylate cyclase
E2K99_RS01415	COG4251	negative regulation of phosphorylation
E2K99_RS01415	COG2203	Gaf domain
E2K99_RS01415	COG3706	GGDEF domain
E2K99_RS01420	COG1309	transcriptional regulator
E2K99_RS01430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2K99_RS01450	COG0395	ABC-type sugar transport system, permease component
E2K99_RS01460	COG1653	transport
E2K99_RS01485	COG2814	Major facilitator Superfamily
E2K99_RS01490	COG4251	negative regulation of phosphorylation
E2K99_RS01490	COG3706	GGDEF domain
E2K99_RS01490	COG5001	Diguanylate cyclase
E2K99_RS01490	COG2203	Gaf domain
E2K99_RS01530	COG0811	peptide transport
E2K99_RS01570	COG4221	oxidoreductase activity
E2K99_RS01575	COG0443	Heat shock 70 kDa protein
E2K99_RS01585	COG2271	Major facilitator Superfamily
E2K99_RS01595	COG0656	L-ascorbic acid biosynthetic process
E2K99_RS01620	COG1234	tRNA 3'-trailer cleavage
E2K99_RS01625	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E2K99_RS01645	COG0659	secondary active sulfate transmembrane transporter activity
E2K99_RS01660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2K99_RS01665	COG0657	acetylesterase activity
E2K99_RS01675	COG2207	Transcriptional regulator
E2K99_RS01680	COG0667	Aldo Keto reductase
E2K99_RS01690	COG4804	nuclease activity
E2K99_RS01710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2K99_RS01735	COG2001	Belongs to the MraZ family
E2K99_RS01740	COG0275	rRNA processing
E2K99_RS01745	COG3116	cell division
E2K99_RS01755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E2K99_RS01760	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E2K99_RS01765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E2K99_RS01770	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E2K99_RS01780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E2K99_RS01785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E2K99_RS01790	COG1181	Belongs to the D-alanine--D-alanine ligase family
E2K99_RS01795	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E2K99_RS01805	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E2K99_RS01810	COG0678	peroxiredoxin activity
E2K99_RS01815	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E2K99_RS01825	COG1196	nuclear chromosome segregation
E2K99_RS01825	COG0741	lytic transglycosylase activity
E2K99_RS01825	COG0739	heme binding
E2K99_RS01830	COG0653	protein targeting
E2K99_RS01845	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E2K99_RS01855	COG0494	nUDIX hydrolase
E2K99_RS01860	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E2K99_RS01865	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E2K99_RS01890	COG4536	flavin adenine dinucleotide binding
E2K99_RS01905	COG3842	ATPase activity
E2K99_RS01910	COG1176	ABC-type spermidine putrescine transport system, permease component I
E2K99_RS01915	COG1177	transmembrane transport
E2K99_RS01945	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E2K99_RS02050	COG0210	DNA helicase
E2K99_RS02085	COG0142	geranyltranstransferase activity
E2K99_RS02090	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E2K99_RS02095	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E2K99_RS02100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E2K99_RS02105	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E2K99_RS02115	COG0494	nUDIX hydrolase
E2K99_RS02120	COG0442	prolyl-tRNA aminoacylation
E2K99_RS02135	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E2K99_RS02140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2K99_RS02145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2K99_RS02165	COG3023	N-Acetylmuramoyl-L-alanine amidase
E2K99_RS02205	COG0762	integral membrane protein
E2K99_RS02215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E2K99_RS02225	COG2264	protein methyltransferase activity
E2K99_RS02230	COG0439	Biotin carboxylase
E2K99_RS02235	COG0511	ligase activity, forming carbon-carbon bonds
E2K99_RS02240	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E2K99_RS02245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E2K99_RS02255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E2K99_RS02260	COG3150	esterase
E2K99_RS02265	COG3161	chorismate lyase activity
E2K99_RS02270	COG0557	exoribonuclease II activity
E2K99_RS02280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E2K99_RS02285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E2K99_RS02300	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E2K99_RS02315	COG1490	D-aminoacyl-tRNA deacylase activity
E2K99_RS02335	COG3550	peptidyl-serine autophosphorylation
E2K99_RS02345	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E2K99_RS02350	COG0138	bifunctional purine biosynthesis protein purh
E2K99_RS02375	COG0415	Belongs to the DNA photolyase family
E2K99_RS02380	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E2K99_RS02385	COG2354	Protein conserved in bacteria
E2K99_RS02390	COG0632	four-way junction helicase activity
E2K99_RS02395	COG2255	four-way junction helicase activity
E2K99_RS02405	COG1671	Belongs to the UPF0178 family
E2K99_RS02415	COG0525	valine-tRNA ligase activity
E2K99_RS02420	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E2K99_RS02430	COG2022	thiamine diphosphate biosynthetic process
E2K99_RS02435	COG0351	phosphomethylpyrimidine kinase
E2K99_RS02440	COG0352	thiamine-phosphate diphosphorylase activity
E2K99_RS02460	COG0783	Belongs to the Dps family
E2K99_RS02475	COG0210	DNA helicase
E2K99_RS02500	COG1175	transmembrane transport
E2K99_RS02515	COG3842	ATPase activity
E2K99_RS02520	COG0246	Mannitol dehydrogenase
E2K99_RS02525	COG1070	Carbohydrate kinase
E2K99_RS02535	COG0840	transmembrane signaling receptor activity
E2K99_RS02545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E2K99_RS02560	COG1611	Belongs to the LOG family
E2K99_RS02565	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E2K99_RS02565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E2K99_RS02570	COG0840	transmembrane signaling receptor activity
E2K99_RS02575	COG0412	Dienelactone hydrolase
E2K99_RS02590	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
E2K99_RS02605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2K99_RS02615	COG1678	Uncharacterized ACR, COG1678
E2K99_RS02620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E2K99_RS02625	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E2K99_RS02630	COG0540	Belongs to the ATCase OTCase family
E2K99_RS02645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E2K99_RS02655	COG1091	dTDP-4-dehydrorhamnose reductase activity
E2K99_RS02680	COG0438	transferase activity, transferring glycosyl groups
E2K99_RS02685	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E2K99_RS02715	COG0463	Glycosyl transferase, family 2
E2K99_RS02750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E2K99_RS02760	COG0859	PFAM glycosyl transferase family 9
E2K99_RS02815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2K99_RS02820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2K99_RS02825	COG1309	transcriptional regulator
E2K99_RS02830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E2K99_RS02835	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E2K99_RS02870	COG1968	undecaprenyl-diphosphatase activity
E2K99_RS02875	COG1968	undecaprenyl-diphosphatase activity
E2K99_RS02880	COG0514	ATP-dependent DNA helicase (RecQ)
E2K99_RS02890	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E2K99_RS02955	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E2K99_RS02960	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E2K99_RS02965	COG1278	Cold shock
E2K99_RS02975	COG0583	DNA-binding transcription factor activity
E2K99_RS02980	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS02985	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E2K99_RS02990	COG2860	membrane
E2K99_RS03000	COG0840	transmembrane signaling receptor activity
E2K99_RS03015	COG0500	methyltransferase
E2K99_RS03035	COG2378	regulation of single-species biofilm formation
E2K99_RS03050	COG0583	DNA-binding transcription factor activity
E2K99_RS03070	COG1971	Probably functions as a manganese efflux pump
E2K99_RS03080	COG0129	dihydroxy-acid dehydratase activity
E2K99_RS03085	COG0628	permease
E2K99_RS03090	COG0346	lactoylglutathione lyase activity
E2K99_RS03100	COG2814	Major facilitator Superfamily
E2K99_RS03105	COG0840	transmembrane signaling receptor activity
E2K99_RS03150	COG0784	Response regulator, receiver
E2K99_RS03150	COG4191	Histidine kinase
E2K99_RS03155	COG3300	MHYT domain
E2K99_RS03155	COG5001	Diguanylate cyclase
E2K99_RS03160	COG3546	catalase activity
E2K99_RS03165	COG0428	transporter
E2K99_RS03195	COG1063	alcohol dehydrogenase
E2K99_RS03200	COG0840	transmembrane signaling receptor activity
E2K99_RS03205	COG2199	diguanylate cyclase activity
E2K99_RS03205	COG2200	EAL domain
E2K99_RS03205	COG2203	Gaf domain
E2K99_RS03235	COG0004	ammonium transporteR
E2K99_RS03240	COG2207	Transcriptional regulator
E2K99_RS03245	COG0300	oxidoreductase activity
E2K99_RS03255	COG1414	Transcriptional regulator
E2K99_RS03260	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS03265	COG2271	Major facilitator Superfamily
E2K99_RS03270	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS03280	COG0583	DNA-binding transcription factor activity
E2K99_RS03285	COG3384	dioxygenase
E2K99_RS03305	COG1981	membrane
E2K99_RS03310	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E2K99_RS03325	COG0495	leucyl-tRNA aminoacylation
E2K99_RS03330	COG1609	Transcriptional regulator
E2K99_RS03340	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E2K99_RS03350	COG3842	ATPase activity
E2K99_RS03355	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E2K99_RS03375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E2K99_RS03380	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2K99_RS03385	COG0735	belongs to the Fur family
E2K99_RS03390	COG1420	regulation of RNA biosynthetic process
E2K99_RS03405	COG0497	DNA recombination
E2K99_RS03410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E2K99_RS03415	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E2K99_RS03420	COG0443	Heat shock 70 kDa protein
E2K99_RS03425	COG0484	heat shock protein binding
E2K99_RS03430	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E2K99_RS03435	COG1428	Deoxynucleoside kinase
E2K99_RS03450	COG1366	Belongs to the anti-sigma-factor antagonist family
E2K99_RS03455	COG0643	Histidine kinase
E2K99_RS03455	COG2198	Histidine kinase
E2K99_RS03460	COG0840	transmembrane signaling receptor activity
E2K99_RS03465	COG0835	chemotaxis
E2K99_RS03475	COG2201	protein-glutamate methylesterase activity
E2K99_RS03480	COG4251	negative regulation of phosphorylation
E2K99_RS03480	COG5001	Diguanylate cyclase
E2K99_RS03480	COG2203	Gaf domain
E2K99_RS03480	COG3706	GGDEF domain
E2K99_RS03490	COG0617	tRNA 3'-terminal CCA addition
E2K99_RS03500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E2K99_RS03505	COG0628	permease
E2K99_RS03525	COG2308	Evidence 4 Homologs of previously reported genes of
E2K99_RS03550	COG2307	Protein conserved in bacteria
E2K99_RS03550	COG2308	Evidence 4 Homologs of previously reported genes of
E2K99_RS03555	COG1305	Transglutaminase-like
E2K99_RS03560	COG2814	Major facilitator Superfamily
E2K99_RS03565	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E2K99_RS03575	COG0642	Histidine kinase
E2K99_RS03595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2K99_RS03600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2K99_RS03630	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E2K99_RS03635	COG0861	Integral membrane protein TerC family
E2K99_RS03645	COG0315	cyclic pyranopterin monophosphate synthase activity
E2K99_RS03650	COG4783	chaperone-mediated protein folding
E2K99_RS03690	COG0126	phosphoglycerate kinase activity
E2K99_RS03695	COG0469	pyruvate kinase activity
E2K99_RS03705	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E2K99_RS03710	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E2K99_RS03715	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E2K99_RS03720	COG0009	L-threonylcarbamoyladenylate synthase
E2K99_RS03725	COG3047	cAMP biosynthetic process
E2K99_RS03730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E2K99_RS03735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2K99_RS03740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E2K99_RS03745	COG0259	pyridoxamine-phosphate oxidase activity
E2K99_RS03750	COG2353	YceI-like domain
E2K99_RS03760	COG3038	cytochrome b561
E2K99_RS03815	COG0482	sulfurtransferase activity
E2K99_RS03830	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
E2K99_RS03850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2K99_RS03855	COG0006	proline dipeptidase activity
E2K99_RS03870	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E2K99_RS03875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2K99_RS03880	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E2K99_RS03885	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E2K99_RS03895	COG5001	Diguanylate cyclase
E2K99_RS03905	COG0038	chloride channel
E2K99_RS03925	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E2K99_RS03930	COG0751	glycine-tRNA ligase activity
E2K99_RS03935	COG0752	glycyl-tRNA synthetase alpha subunit
E2K99_RS03940	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E2K99_RS03945	COG4535	Mg2 and Co2 transporter CorC
E2K99_RS03950	COG0840	transmembrane signaling receptor activity
E2K99_RS03955	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E2K99_RS03960	COG1702	phosphate starvation-inducible protein PhoH
E2K99_RS03965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E2K99_RS03975	COG1335	isochorismatase
E2K99_RS03985	COG1879	ABC-type sugar transport system periplasmic component
E2K99_RS03990	COG1129	ABC transporter
E2K99_RS03995	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2K99_RS04010	COG4251	negative regulation of phosphorylation
E2K99_RS04010	COG5001	Diguanylate cyclase
E2K99_RS04010	COG2203	Gaf domain
E2K99_RS04010	COG3706	GGDEF domain
E2K99_RS04015	COG1464	Belongs to the NlpA lipoprotein family
E2K99_RS04030	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E2K99_RS04035	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E2K99_RS04045	COG2202	Pas domain
E2K99_RS04045	COG2200	EAL domain
E2K99_RS04045	COG2199	diguanylate cyclase activity
E2K99_RS04050	COG0586	Pfam SNARE associated Golgi protein
E2K99_RS04055	COG0860	N-Acetylmuramoyl-L-alanine amidase
E2K99_RS04060	COG0802	atpase or kinase
E2K99_RS04065	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E2K99_RS04080	COG4566	intracellular signal transduction
E2K99_RS04115	COG4974	Belongs to the 'phage' integrase family
E2K99_RS04120	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E2K99_RS04125	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E2K99_RS04130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E2K99_RS04135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E2K99_RS04150	COG0534	Mate efflux family protein
E2K99_RS04160	COG0254	rRNA binding
E2K99_RS04165	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E2K99_RS04180	COG1074	ATP-dependent DNA helicase activity
E2K99_RS04190	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E2K99_RS04195	COG2081	HI0933 family
E2K99_RS04200	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E2K99_RS04215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E2K99_RS04245	COG0583	DNA-binding transcription factor activity
E2K99_RS04255	COG0277	FAD linked oxidase domain protein
E2K99_RS04260	COG0583	DNA-binding transcription factor activity
E2K99_RS04265	COG1012	belongs to the aldehyde dehydrogenase family
E2K99_RS04275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2K99_RS04285	COG3829	transcription factor binding
E2K99_RS04295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2K99_RS04310	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2K99_RS04345	COG1595	DNA-templated transcription, initiation
E2K99_RS04355	COG0471	metal ion transport
E2K99_RS04390	COG3842	ATPase activity
E2K99_RS04405	COG0395	ABC-type sugar transport system, permease component
E2K99_RS04420	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E2K99_RS04430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2K99_RS04455	COG2144	transferase activity, transferring acyl groups
E2K99_RS04460	COG0438	transferase activity, transferring glycosyl groups
E2K99_RS04470	COG2072	flavoprotein involved in K transport
E2K99_RS04480	COG2223	nitrite transmembrane transporter activity
E2K99_RS04485	COG2207	Transcriptional regulator
E2K99_RS04500	COG1960	acyl-CoA dehydrogenase activity
E2K99_RS04520	COG4681	YaeQ
E2K99_RS04535	COG2951	lytic endotransglycosylase activity
E2K99_RS04540	COG0123	including yeast histone deacetylase and acetoin utilization protein
E2K99_RS04550	COG0477	Major facilitator Superfamily
E2K99_RS04555	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E2K99_RS04565	COG2011	ABC-type metal ion transport system permease component
E2K99_RS04570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E2K99_RS04590	COG0459	protein refolding
E2K99_RS04595	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E2K99_RS04600	COG4772	TonB-dependent receptor
E2K99_RS04610	COG1595	DNA-templated transcription, initiation
E2K99_RS04615	COG3712	iron ion homeostasis
E2K99_RS04650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2K99_RS04680	COG2831	hemolysin activation secretion protein
E2K99_RS04690	COG3210	domain, Protein
E2K99_RS04695	COG3210	domain, Protein
E2K99_RS04700	COG5001	Diguanylate cyclase
E2K99_RS04700	COG3300	MHYT domain
E2K99_RS04720	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2K99_RS04725	COG1129	ABC transporter
E2K99_RS04735	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2K99_RS04745	COG4154	Belongs to the RbsD FucU family
E2K99_RS04750	COG1012	belongs to the aldehyde dehydrogenase family
E2K99_RS04760	COG1349	DNA-binding transcription factor activity
E2K99_RS04765	COG0024	Methionine aminopeptidase
E2K99_RS04770	COG0583	DNA-binding transcription factor activity
E2K99_RS04775	COG1819	glycosyl
E2K99_RS04780	COG2223	nitrite transmembrane transporter activity
E2K99_RS04795	COG4948	Mandelate Racemase Muconate Lactonizing
E2K99_RS04800	COG0800	Aldolase
E2K99_RS04805	COG3734	2-keto-3-deoxy-galactonokinase
E2K99_RS04820	COG1879	ABC-type sugar transport system periplasmic component
E2K99_RS04825	COG1129	ABC transporter
E2K99_RS04830	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2K99_RS04835	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2K99_RS04840	COG4213	ABC transporter substrate-binding protein
E2K99_RS04850	COG4214	carbohydrate transport
E2K99_RS04885	COG4948	Mandelate Racemase Muconate Lactonizing
E2K99_RS04890	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS04895	COG3254	rhamnose metabolic process
E2K99_RS04905	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2K99_RS04910	COG1879	ABC-type sugar transport system periplasmic component
E2K99_RS04915	COG3618	amidohydrolase
E2K99_RS04920	COG1309	transcriptional regulator
E2K99_RS04935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E2K99_RS04945	COG0300	oxidoreductase activity
E2K99_RS04970	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS04980	COG1879	ABC-type sugar transport system periplasmic component
E2K99_RS04985	COG1129	ABC transporter
E2K99_RS04990	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2K99_RS05025	COG5001	Diguanylate cyclase
E2K99_RS05040	COG0625	glutathione transferase activity
E2K99_RS05045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2K99_RS05045	COG1017	nitric oxide dioxygenase activity
E2K99_RS05050	COG0583	DNA-binding transcription factor activity
E2K99_RS05060	COG3550	peptidyl-serine autophosphorylation
E2K99_RS05075	COG1177	transmembrane transport
E2K99_RS05080	COG1176	ABC-type spermidine putrescine transport system, permease component I
E2K99_RS05090	COG3842	ATPase activity
E2K99_RS05095	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E2K99_RS05115	COG1253	flavin adenine dinucleotide binding
E2K99_RS05130	COG0405	Gamma-glutamyltransferase
E2K99_RS05135	COG1609	Transcriptional regulator
E2K99_RS05140	COG0583	DNA-binding transcription factor activity
E2K99_RS05155	COG1070	Carbohydrate kinase
E2K99_RS05160	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS05165	COG1063	alcohol dehydrogenase
E2K99_RS05175	COG0840	transmembrane signaling receptor activity
E2K99_RS05180	COG1063	alcohol dehydrogenase
E2K99_RS05195	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS05200	COG1879	ABC-type sugar transport system periplasmic component
E2K99_RS05205	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2K99_RS05210	COG1129	ABC transporter
E2K99_RS05215	COG0698	ribose 5-phosphate isomerase
E2K99_RS05220	COG2390	Transcriptional regulator
E2K99_RS05230	COG1737	Transcriptional regulator
E2K99_RS05235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E2K99_RS05245	COG0129	dihydroxy-acid dehydratase activity
E2K99_RS05250	COG0800	Aldolase
E2K99_RS05260	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E2K99_RS05265	COG0583	DNA-binding transcription factor activity
E2K99_RS05270	COG4654	Cytochrome c, class I
E2K99_RS05275	COG3958	Transketolase
E2K99_RS05280	COG3959	Transketolase, thiamine diphosphate binding domain
E2K99_RS05285	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E2K99_RS05290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E2K99_RS05295	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS05300	COG0583	DNA-binding transcription factor activity
E2K99_RS05310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2K99_RS05315	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E2K99_RS05320	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
E2K99_RS05340	COG2814	Major facilitator Superfamily
E2K99_RS05345	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E2K99_RS05360	COG2030	dehydratase
E2K99_RS05370	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E2K99_RS05375	COG1522	sequence-specific DNA binding
E2K99_RS05380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E2K99_RS05385	COG0454	-acetyltransferase
E2K99_RS05390	COG1012	belongs to the aldehyde dehydrogenase family
E2K99_RS05395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2K99_RS05400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2K99_RS05420	COG0747	negative chemotaxis
E2K99_RS05425	COG0601	transmembrane transport
E2K99_RS05430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2K99_RS05445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2K99_RS05450	COG0583	DNA-binding transcription factor activity
E2K99_RS05455	COG0251	oxidation-reduction process
E2K99_RS05465	COG1473	amidohydrolase
E2K99_RS05475	COG0583	DNA-binding transcription factor activity
E2K99_RS05485	COG0840	transmembrane signaling receptor activity
E2K99_RS05490	COG0583	DNA-binding transcription factor activity
E2K99_RS05495	COG1960	acyl-CoA dehydrogenase activity
E2K99_RS05500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2K99_RS05505	COG1024	Enoyl-CoA hydratase
E2K99_RS05510	COG1960	acyl-CoA dehydrogenase activity
E2K99_RS05515	COG1960	acyl-CoA dehydrogenase activity
E2K99_RS05520	COG0183	Belongs to the thiolase family
E2K99_RS05525	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2K99_RS05525	COG1024	Enoyl-CoA hydratase
E2K99_RS05560	COG0281	malic enzyme
E2K99_RS05560	COG0280	phosphate acetyltransferase
E2K99_RS05580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2K99_RS05590	COG1609	Transcriptional regulator
E2K99_RS05625	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E2K99_RS05630	COG1570	exodeoxyribonuclease VII activity
E2K99_RS05635	COG0811	peptide transport
E2K99_RS05640	COG0848	biopolymer transport protein
E2K99_RS05645	COG1663	tetraacyldisaccharide 4'-kinase activity
E2K99_RS05650	COG2835	tetraacyldisaccharide 4'-kinase activity
E2K99_RS05655	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E2K99_RS05660	COG0563	adenylate kinase activity
E2K99_RS05665	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E2K99_RS05690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E2K99_RS05695	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E2K99_RS05695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E2K99_RS05700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2K99_RS05705	COG0668	transmembrane transport
E2K99_RS05715	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E2K99_RS05720	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E2K99_RS05725	COG2003	Belongs to the UPF0758 family
E2K99_RS05730	COG1047	Peptidyl-prolyl cis-trans
E2K99_RS05735	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E2K99_RS05740	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2K99_RS05800	COG2193	ferroxidase activity
E2K99_RS05805	COG3237	CsbD-like
E2K99_RS05825	COG2201	protein-glutamate methylesterase activity
E2K99_RS05860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2K99_RS05870	COG1116	anion transmembrane transporter activity
E2K99_RS05875	COG2363	Small membrane protein
E2K99_RS05890	COG0659	secondary active sulfate transmembrane transporter activity
E2K99_RS05900	COG2186	Transcriptional regulator
E2K99_RS05905	COG1304	FMN binding
E2K99_RS05910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2K99_RS05935	COG0823	Involved in the tonB-independent uptake of proteins
E2K99_RS05955	COG0824	Thioesterase
E2K99_RS05960	COG4221	oxidoreductase activity
E2K99_RS05965	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E2K99_RS05970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E2K99_RS05995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E2K99_RS06000	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E2K99_RS06005	COG0343	queuine tRNA-ribosyltransferase activity
E2K99_RS06010	COG2198	Histidine kinase
E2K99_RS06010	COG0784	Response regulator, receiver
E2K99_RS06010	COG2205	protein histidine kinase activity
E2K99_RS06015	COG2197	response regulator
E2K99_RS06020	COG2205	protein histidine kinase activity
E2K99_RS06050	COG1862	Preprotein translocase
E2K99_RS06055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E2K99_RS06060	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E2K99_RS06065	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E2K99_RS06070	COG0697	spore germination
E2K99_RS06095	COG1864	DNA RNA non-specific endonuclease
E2K99_RS06095	COG3591	Belongs to the peptidase S1B family
E2K99_RS06100	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS06115	COG0438	transferase activity, transferring glycosyl groups
E2K99_RS06115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E2K99_RS06120	COG0840	transmembrane signaling receptor activity
E2K99_RS06140	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E2K99_RS06145	COG0573	inorganic phosphate transmembrane transporter activity
E2K99_RS06155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E2K99_RS06160	COG0704	Plays a role in the regulation of phosphate uptake
E2K99_RS06180	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS06200	COG1522	sequence-specific DNA binding
E2K99_RS06220	COG0765	amino acid transport
E2K99_RS06225	COG1126	abc transporter atp-binding protein
E2K99_RS06230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2K99_RS06235	COG0840	transmembrane signaling receptor activity
E2K99_RS06240	COG0583	DNA-binding transcription factor activity
E2K99_RS06255	COG0583	DNA-binding transcription factor activity
E2K99_RS06270	COG1733	regulation of RNA biosynthetic process
E2K99_RS06275	COG2207	Transcriptional regulator
E2K99_RS06280	COG4773	Receptor
E2K99_RS06310	COG0165	Argininosuccinate lyase
E2K99_RS06315	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS06320	COG0583	DNA-binding transcription factor activity
E2K99_RS06340	COG1215	transferase activity, transferring glycosyl groups
E2K99_RS06345	COG1215	transferase activity, transferring glycosyl groups
E2K99_RS06350	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
E2K99_RS06355	COG0457	Tetratricopeptide repeat
E2K99_RS06390	COG1196	nuclear chromosome segregation
E2K99_RS06405	COG1366	Belongs to the anti-sigma-factor antagonist family
E2K99_RS06410	COG1366	Belongs to the anti-sigma-factor antagonist family
E2K99_RS06415	COG2172	sigma factor antagonist activity
E2K99_RS06425	COG0784	Response regulator, receiver
E2K99_RS06425	COG2198	Histidine kinase
E2K99_RS06425	COG2205	protein histidine kinase activity
E2K99_RS06430	COG0784	Response regulator, receiver
E2K99_RS06430	COG2205	protein histidine kinase activity
E2K99_RS06435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E2K99_RS06440	COG4829	muconolactone delta-isomerase
E2K99_RS06455	COG3485	protocatechuate 3,4-dioxygenase
E2K99_RS06475	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS06480	COG0251	oxidation-reduction process
E2K99_RS06485	COG2814	Major facilitator Superfamily
E2K99_RS06490	COG3135	benzoate transporter
E2K99_RS06495	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E2K99_RS06500	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E2K99_RS06505	COG0840	transmembrane signaling receptor activity
E2K99_RS06510	COG3284	Transcriptional regulator
E2K99_RS06525	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E2K99_RS06540	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
E2K99_RS06545	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E2K99_RS06555	COG0840	transmembrane signaling receptor activity
E2K99_RS06560	COG4566	intracellular signal transduction
E2K99_RS06580	COG4638	Rieske (2fe-2S)
E2K99_RS06585	COG0154	amidase activity
E2K99_RS06595	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2K99_RS06600	COG4191	Histidine kinase
E2K99_RS06615	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS06640	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E2K99_RS06675	COG3384	dioxygenase
E2K99_RS06685	COG0583	DNA-binding transcription factor activity
E2K99_RS06690	COG2828	Protein conserved in bacteria
E2K99_RS06695	COG2159	amidohydrolase
E2K99_RS06705	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2K99_RS06715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2K99_RS06720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2K99_RS06740	COG2271	Major facilitator Superfamily
E2K99_RS06745	COG0154	amidase activity
E2K99_RS06770	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E2K99_RS06775	COG2990	Protein conserved in bacteria
E2K99_RS06780	COG4774	siderophore transport
E2K99_RS06785	COG3712	iron ion homeostasis
E2K99_RS06795	COG2203	Gaf domain
E2K99_RS06795	COG4251	negative regulation of phosphorylation
E2K99_RS06795	COG5001	Diguanylate cyclase
E2K99_RS06795	COG3706	GGDEF domain
E2K99_RS06800	COG0840	transmembrane signaling receptor activity
E2K99_RS06810	COG0840	transmembrane signaling receptor activity
E2K99_RS06815	COG5001	Diguanylate cyclase
E2K99_RS06815	COG1716	ATPase activity
E2K99_RS06830	COG0745	RESPONSE REGULATOR receiver
E2K99_RS06830	COG3292	Two component regulator propeller
E2K99_RS06830	COG2205	protein histidine kinase activity
E2K99_RS06840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E2K99_RS06880	COG1739	Uncharacterized protein family UPF0029
E2K99_RS06890	COG1752	Esterase of the alpha-beta hydrolase superfamily
E2K99_RS06895	COG0791	NLP P60 protein
E2K99_RS06900	COG3193	protein, possibly involved in utilization of glycolate and propanediol
E2K99_RS06905	COG0505	Belongs to the CarA family
E2K99_RS06910	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E2K99_RS06915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E2K99_RS06920	COG1534	Rna-binding protein
E2K99_RS06925	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E2K99_RS06930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E2K99_RS06935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E2K99_RS06940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E2K99_RS06950	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E2K99_RS06950	COG2010	Cytochrome c
E2K99_RS06965	COG0488	(ABC) transporter
E2K99_RS06975	COG0728	peptidoglycan biosynthetic process
E2K99_RS06980	COG0268	Binds directly to 16S ribosomal RNA
E2K99_RS07000	COG1278	Cold shock
E2K99_RS07005	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E2K99_RS07010	COG0542	response to heat
E2K99_RS07020	COG0756	dUTP diphosphatase activity
E2K99_RS07025	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E2K99_RS07030	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E2K99_RS07035	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E2K99_RS07040	COG0196	riboflavin kinase activity
E2K99_RS07045	COG1802	Transcriptional regulator
E2K99_RS07060	COG3845	ABC transporter
E2K99_RS07065	COG1335	isochorismatase
E2K99_RS07070	COG1079	Belongs to the binding-protein-dependent transport system permease family
E2K99_RS07085	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E2K99_RS07090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2K99_RS07110	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E2K99_RS07120	COG0454	-acetyltransferase
E2K99_RS07120	COG0456	acetyltransferase
E2K99_RS07125	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E2K99_RS07135	COG2226	methyltransferase
E2K99_RS07140	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E2K99_RS07150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E2K99_RS07155	COG0312	modulator of DNA gyrase
E2K99_RS07160	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E2K99_RS07180	COG1666	GTP binding
E2K99_RS07185	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E2K99_RS07190	COG3123	guanosine phosphorylase activity
E2K99_RS07195	COG0137	argininosuccinate synthase activity
E2K99_RS07200	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E2K99_RS07210	COG1162	GTPase activity
E2K99_RS07215	COG2154	pterin-4-alpha-carbinolamine dehydratase
E2K99_RS07220	COG0501	Belongs to the peptidase M48B family
E2K99_RS07225	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E2K99_RS07230	COG3318	Belongs to the UPF0149 family
E2K99_RS07230	COG3012	SEC-C Motif Domain Protein
E2K99_RS07240	COG0519	Catalyzes the synthesis of GMP from XMP
E2K99_RS07245	COG1674	ftsk spoiiie
E2K99_RS07245	COG1674	ftsk spoiiie
E2K99_RS07255	COG1295	ribonuclease BN
E2K99_RS07280	COG0243	molybdopterin cofactor binding
E2K99_RS07310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2K99_RS07345	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E2K99_RS07350	COG2918	glutathione biosynthetic process
E2K99_RS07355	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E2K99_RS07360	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2K99_RS07365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2K99_RS07375	COG0840	transmembrane signaling receptor activity
E2K99_RS07390	COG0583	DNA-binding transcription factor activity
E2K99_RS07410	COG0473	3-isopropylmalate dehydrogenase activity
E2K99_RS07415	COG0676	glucose-6-phosphate 1-epimerase activity
E2K99_RS07420	COG0583	DNA-binding transcription factor activity
E2K99_RS07430	COG1910	domain protein
E2K99_RS07435	COG2223	nitrite transmembrane transporter activity
E2K99_RS07450	COG3383	formate dehydrogenase (NAD+) activity
E2K99_RS07455	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E2K99_RS07495	COG0583	DNA-binding transcription factor activity
E2K99_RS07500	COG2329	Antibiotic biosynthesis monooxygenase
E2K99_RS07515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2K99_RS07520	COG1116	anion transmembrane transporter activity
E2K99_RS07520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2K99_RS07545	COG1609	Transcriptional regulator
E2K99_RS07555	COG0765	amino acid transport
E2K99_RS07560	COG0765	amino acid transport
E2K99_RS07575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E2K99_RS07595	COG1960	acyl-CoA dehydrogenase activity
E2K99_RS07605	COG0228	four-way junction DNA binding
E2K99_RS07610	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E2K99_RS07615	COG0336	Belongs to the RNA methyltransferase TrmD family
E2K99_RS07620	COG0335	large ribosomal subunit rRNA binding
E2K99_RS07630	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E2K99_RS07640	COG0114	fumarate hydratase activity
E2K99_RS07690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2K99_RS07695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2K99_RS07700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2K99_RS07710	COG0512	Glutamine amidotransferase of anthranilate synthase
E2K99_RS07710	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E2K99_RS07715	COG0477	Major facilitator Superfamily
E2K99_RS07720	COG0697	spore germination
E2K99_RS07725	COG0598	Magnesium transport protein CorA
E2K99_RS07740	COG0601	transmembrane transport
E2K99_RS07745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2K99_RS07750	COG4172	Belongs to the ABC transporter superfamily
E2K99_RS07760	COG4251	negative regulation of phosphorylation
E2K99_RS07760	COG5001	Diguanylate cyclase
E2K99_RS07760	COG2203	Gaf domain
E2K99_RS07760	COG3706	GGDEF domain
E2K99_RS07785	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
E2K99_RS07815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E2K99_RS07830	COG5001	Diguanylate cyclase
E2K99_RS07830	COG3706	GGDEF domain
E2K99_RS07830	COG4251	negative regulation of phosphorylation
E2K99_RS07830	COG2203	Gaf domain
E2K99_RS07850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2K99_RS07860	COG0745	RESPONSE REGULATOR receiver
E2K99_RS07870	COG0745	RESPONSE REGULATOR receiver
E2K99_RS07885	COG0840	transmembrane signaling receptor activity
E2K99_RS07905	COG3093	addiction module antidote protein HigA
E2K99_RS07915	COG2011	ABC-type metal ion transport system permease component
E2K99_RS07925	COG1104	cysteine desulfurase activity
E2K99_RS07930	COG0583	DNA-binding transcription factor activity
E2K99_RS07935	COG2072	flavoprotein involved in K transport
E2K99_RS07940	COG0601	transmembrane transport
E2K99_RS07945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2K99_RS07950	COG0444	Belongs to the ABC transporter superfamily
E2K99_RS07955	COG4608	Belongs to the ABC transporter superfamily
E2K99_RS07960	COG0747	negative chemotaxis
E2K99_RS07985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2K99_RS07990	COG0583	DNA-binding transcription factor activity
E2K99_RS08000	COG1045	serine acetyltransferase
E2K99_RS08020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2K99_RS08050	COG0318	PFAM AMP-dependent synthetase and ligase
E2K99_RS08060	COG2132	Multicopper oxidase
E2K99_RS08080	COG0789	Transcriptional regulator
E2K99_RS08085	COG2267	carboxylic ester hydrolase activity
E2K99_RS08090	COG0673	inositol 2-dehydrogenase activity
E2K99_RS08095	COG0789	Transcriptional regulator
E2K99_RS08100	COG2217	Heavy metal translocating P-type atpase
E2K99_RS08120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E2K99_RS08160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E2K99_RS08165	COG2878	Part of a membrane complex involved in electron transport
E2K99_RS08175	COG0492	ferredoxin-NADP+ reductase activity
E2K99_RS08180	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E2K99_RS08190	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E2K99_RS08240	COG1546	Belongs to the CinA family
E2K99_RS08240	COG1058	Belongs to the CinA family
E2K99_RS08250	COG0123	including yeast histone deacetylase and acetoin utilization protein
E2K99_RS08265	COG2226	methyltransferase
E2K99_RS08280	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E2K99_RS08295	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E2K99_RS08300	COG0431	NADPH-dependent FMN reductase
E2K99_RS08305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2K99_RS08310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2K99_RS08315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2K99_RS08320	COG1116	anion transmembrane transporter activity
E2K99_RS08325	COG3585	molybdate ion transport
E2K99_RS08340	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E2K99_RS08345	COG4208	sulfate ABC transporter
E2K99_RS08350	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E2K99_RS08355	COG0583	DNA-binding transcription factor activity
E2K99_RS08425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2K99_RS08430	COG2814	Major facilitator Superfamily
E2K99_RS08445	COG1522	sequence-specific DNA binding
E2K99_RS08450	COG2169	Transcriptional regulator
E2K99_RS08450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E2K99_RS08470	COG2831	hemolysin activation secretion protein
E2K99_RS08480	COG3210	domain, Protein
E2K99_RS08480	COG3210	domain, Protein
E2K99_RS08495	COG1879	ABC-type sugar transport system periplasmic component
E2K99_RS08500	COG1129	ABC transporter
E2K99_RS08505	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2K99_RS08515	COG3386	PFAM SMP-30 Gluconolaconase
E2K99_RS08530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2K99_RS08540	COG0243	molybdopterin cofactor binding
E2K99_RS08550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2K99_RS08570	COG4771	TonB-dependent receptor
E2K99_RS08595	COG1477	protein flavinylation
E2K99_RS08600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E2K99_RS08605	COG1253	flavin adenine dinucleotide binding
E2K99_RS08680	COG0513	Belongs to the DEAD box helicase family
E2K99_RS08695	COG0483	inositol monophosphate 1-phosphatase activity
E2K99_RS08710	COG1187	pseudouridine synthase activity
E2K99_RS08725	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E2K99_RS08735	COG2833	Protein of unknown function (DUF455)
E2K99_RS08745	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E2K99_RS08770	COG0028	Belongs to the TPP enzyme family
E2K99_RS08780	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E2K99_RS08795	COG0688	phosphatidylethanolamine metabolic process
E2K99_RS08800	COG1183	phosphatidylcholine synthase activity
E2K99_RS08825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2K99_RS08845	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E2K99_RS08850	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E2K99_RS08870	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E2K99_RS08875	COG1185	polyribonucleotide nucleotidyltransferase activity
E2K99_RS08880	COG1252	NADH dehydrogenase
E2K99_RS08900	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E2K99_RS08905	COG1984	allophanate hydrolase subunit 2
E2K99_RS08910	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E2K99_RS08925	COG0149	triose-phosphate isomerase activity
E2K99_RS08930	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E2K99_RS08940	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2K99_RS08945	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2K99_RS08950	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2K99_RS08955	COG0649	NAD binding
E2K99_RS08970	COG1034	ATP synthesis coupled electron transport
E2K99_RS08975	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E2K99_RS08980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2K99_RS08990	COG0713	ATP synthesis coupled electron transport
E2K99_RS09005	COG1007	ATP synthesis coupled electron transport
E2K99_RS09015	COG0494	nUDIX hydrolase
E2K99_RS09075	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E2K99_RS09095	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS09135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2K99_RS09170	COG0697	spore germination
E2K99_RS09180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2K99_RS09190	COG1942	4-Oxalocrotonate Tautomerase
E2K99_RS09200	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E2K99_RS09215	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E2K99_RS09230	COG0071	Belongs to the small heat shock protein (HSP20) family
E2K99_RS09240	COG1538	Outer membrane efflux protein
E2K99_RS09245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2K99_RS09250	COG0842	Transport permease protein
E2K99_RS09250	COG1129	ABC transporter
E2K99_RS09255	COG0842	Transport permease protein
E2K99_RS09310	COG0583	DNA-binding transcription factor activity
E2K99_RS09325	COG4172	Belongs to the ABC transporter superfamily
E2K99_RS09330	COG0747	negative chemotaxis
E2K99_RS09365	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E2K99_RS09380	COG0405	Gamma-glutamyltransferase
E2K99_RS09385	COG4608	Belongs to the ABC transporter superfamily
E2K99_RS09390	COG0444	Belongs to the ABC transporter superfamily
E2K99_RS09395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2K99_RS09410	COG1846	Transcriptional regulator
E2K99_RS09420	COG0400	carboxylic ester hydrolase activity
E2K99_RS09430	COG0521	Mo-molybdopterin cofactor biosynthetic process
E2K99_RS09435	COG3028	Belongs to the UPF0307 family
E2K99_RS09440	COG0312	modulator of DNA gyrase
E2K99_RS09450	COG0477	Major facilitator Superfamily
E2K99_RS09455	COG0415	Belongs to the DNA photolyase family
E2K99_RS09460	COG0840	transmembrane signaling receptor activity
E2K99_RS09470	COG0557	exoribonuclease II activity
E2K99_RS09475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E2K99_RS09480	COG1045	serine acetyltransferase
E2K99_RS09485	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E2K99_RS09490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E2K99_RS09510	COG0215	cysteine-tRNA ligase activity
E2K99_RS09520	COG0825	malonyl-CoA metabolic process
E2K99_RS09525	COG0037	tRNA processing
E2K99_RS09545	COG1280	lysine exporter protein (LysE YggA)
E2K99_RS09555	COG3755	Protein conserved in bacteria
E2K99_RS09565	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E2K99_RS09580	COG0303	'Molybdopterin
E2K99_RS09585	COG0746	molybdenum cofactor guanylyltransferase activity
E2K99_RS09590	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E2K99_RS09595	COG1530	ribonuclease E activity
E2K99_RS09620	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E2K99_RS09625	COG0248	Ppx GppA phosphatase
E2K99_RS09630	COG1840	ABC-type Fe3 transport system, periplasmic component
E2K99_RS09650	COG1012	belongs to the aldehyde dehydrogenase family
E2K99_RS09660	COG3284	Transcriptional regulator
E2K99_RS09675	COG2840	Smr protein MutS2
E2K99_RS09685	COG0492	ferredoxin-NADP+ reductase activity
E2K99_RS09690	COG1674	ftsk spoiiie
E2K99_RS09695	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E2K99_RS09705	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E2K99_RS09725	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E2K99_RS09740	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E2K99_RS09745	COG5001	Diguanylate cyclase
E2K99_RS09745	COG3300	MHYT domain
E2K99_RS09780	COG0424	maF-like protein
E2K99_RS09790	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E2K99_RS09795	COG0416	fatty acid biosynthetic process
E2K99_RS09800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E2K99_RS09815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E2K99_RS09820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E2K99_RS09845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2K99_RS09855	COG0481	GTPase activity
E2K99_RS09860	COG0681	Belongs to the peptidase S26 family
E2K99_RS09865	COG0571	ribonuclease III activity
E2K99_RS09870	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E2K99_RS09875	COG1381	Involved in DNA repair and RecF pathway recombination
E2K99_RS09880	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E2K99_RS09885	COG0736	holo-[acyl-carrier-protein] synthase activity
E2K99_RS09895	COG0322	excinuclease ABC activity
E2K99_RS09930	COG0835	chemotaxis
E2K99_RS09930	COG0784	Response regulator, receiver
E2K99_RS09935	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E2K99_RS09940	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E2K99_RS09960	COG1966	Carbon starvation protein
E2K99_RS09965	COG2879	small protein
E2K99_RS09980	COG4251	negative regulation of phosphorylation
E2K99_RS09980	COG3706	GGDEF domain
E2K99_RS09980	COG5001	Diguanylate cyclase
E2K99_RS09980	COG2203	Gaf domain
E2K99_RS09990	COG0501	Belongs to the peptidase M48B family
E2K99_RS09995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E2K99_RS09995	COG4651	solute:proton antiporter activity
E2K99_RS10000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E2K99_RS10030	COG0251	oxidation-reduction process
E2K99_RS10035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E2K99_RS10055	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E2K99_RS10060	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E2K99_RS10065	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E2K99_RS10070	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E2K99_RS10075	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E2K99_RS10080	COG0072	phenylalanine-tRNA ligase activity
E2K99_RS10080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2K99_RS10085	COG0776	regulation of translation
E2K99_RS10165	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E2K99_RS10185	COG1045	serine acetyltransferase
E2K99_RS10190	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E2K99_RS10200	COG1929	Belongs to the glycerate kinase type-1 family
E2K99_RS10250	COG1475	DNA binding
E2K99_RS10260	COG2974	May be involved in recombination
E2K99_RS10285	COG1525	nuclease
E2K99_RS10325	COG1802	Transcriptional regulator
E2K99_RS10325	COG4626	Terminase
E2K99_RS10410	COG4695	Portal protein
E2K99_RS10415	COG0740	serine-type endopeptidase activity
E2K99_RS10515	COG3179	chitinase
E2K99_RS10555	COG1230	cation diffusion facilitator family transporter
E2K99_RS10570	COG1215	transferase activity, transferring glycosyl groups
E2K99_RS10590	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E2K99_RS10595	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E2K99_RS10600	COG2201	protein-glutamate methylesterase activity
E2K99_RS10605	COG0745	RESPONSE REGULATOR receiver
E2K99_RS10615	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E2K99_RS10620	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E2K99_RS10655	COG1815	bacterial-type flagellum-dependent cell motility
E2K99_RS10665	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E2K99_RS10670	COG1749	Flagellar hook protein flgE
E2K99_RS10675	COG4787	bacterial-type flagellum-dependent cell motility
E2K99_RS10685	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E2K99_RS10690	COG1706	bacterial-type flagellum-dependent cell motility
E2K99_RS10695	COG1705	Flagellar rod assembly protein muramidase FlgJ
E2K99_RS10695	COG3951	Flagellar rod assembly protein muramidase FlgJ
E2K99_RS10700	COG1256	bacterial-type flagellum assembly
E2K99_RS10705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E2K99_RS10710	COG1538	Outer membrane efflux protein
E2K99_RS10715	COG1136	(ABC) transporter
E2K99_RS10715	COG0577	efflux transmembrane transporter activity
E2K99_RS10720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2K99_RS10735	COG1338	Plays a role in the flagellum-specific transport system
E2K99_RS10745	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E2K99_RS10755	COG1580	Controls the rotational direction of flagella during chemotaxis
E2K99_RS10770	COG1157	protein secretion by the type III secretion system
E2K99_RS10790	COG1677	Flagellar hook-basal body complex protein FliE
E2K99_RS10795	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
E2K99_RS10800	COG2257	FlhB HrpN YscU SpaS Family
E2K99_RS10845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E2K99_RS10850	COG0360	Binds together with S18 to 16S ribosomal RNA
E2K99_RS10860	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E2K99_RS10865	COG0359	binds to the 23S rRNA
E2K99_RS10870	COG0305	Participates in initiation and elongation during chromosome replication
E2K99_RS10880	COG0306	phosphate transporter
E2K99_RS10885	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E2K99_RS10890	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E2K99_RS10905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2K99_RS10905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E2K99_RS10910	COG0463	Glycosyl transferase, family 2
E2K99_RS10915	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E2K99_RS10920	COG2076	Multidrug Resistance protein
E2K99_RS10935	COG0436	Aminotransferase
E2K99_RS10955	COG0303	'Molybdopterin
E2K99_RS10960	COG3739	integral membrane protein
E2K99_RS10980	COG0314	molybdopterin synthase activity
E2K99_RS10985	COG1914	H( )-stimulated, divalent metal cation uptake system
E2K99_RS11000	COG1566	PFAM secretion protein HlyD family protein
E2K99_RS11020	COG0583	DNA-binding transcription factor activity
E2K99_RS11025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E2K99_RS11030	COG0542	response to heat
E2K99_RS11040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2K99_RS11045	COG1289	transmembrane transporter activity
E2K99_RS11050	COG2224	Isocitrate lyase
E2K99_RS11060	COG4149	molybdate abc transporter
E2K99_RS11065	COG0725	ABC transporter, periplasmic molybdate-binding protein
E2K99_RS11075	COG0038	chloride channel
E2K99_RS11080	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E2K99_RS11085	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E2K99_RS11095	COG1803	Methylglyoxal synthase
E2K99_RS11110	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E2K99_RS11115	COG0583	DNA-binding transcription factor activity
E2K99_RS11125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E2K99_RS11130	COG1758	RNA polymerase activity
E2K99_RS11140	COG1561	YicC-like family, N-terminal region
E2K99_RS11145	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E2K99_RS11150	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E2K99_RS11155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E2K99_RS11170	COG2032	superoxide dismutase activity
E2K99_RS11190	COG0527	aspartate kinase activity
E2K99_RS11200	COG0583	DNA-binding transcription factor activity
E2K99_RS11210	COG1214	PFAM Peptidase M22, glycoprotease
E2K99_RS11220	COG1573	uracil-dna glycosylase
E2K99_RS11230	COG2814	Major facilitator Superfamily
E2K99_RS11235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E2K99_RS11265	COG0765	amino acid transport
E2K99_RS11270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2K99_RS11275	COG0488	(ABC) transporter
E2K99_RS11280	COG2890	protein-(glutamine-N5) methyltransferase activity
E2K99_RS11285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2K99_RS11290	COG1393	Belongs to the ArsC family
E2K99_RS11295	COG2171	N-acyltransferase activity
E2K99_RS11305	COG0840	transmembrane signaling receptor activity
E2K99_RS11320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E2K99_RS11325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E2K99_RS11330	COG0242	peptide deformylase activity
E2K99_RS11335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E2K99_RS11335	COG0189	ligase activity
E2K99_RS11340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E2K99_RS11340	COG1181	Belongs to the D-alanine--D-alanine ligase family
E2K99_RS11345	COG1132	(ABC) transporter
E2K99_RS11355	COG1187	pseudouridine synthase activity
E2K99_RS11360	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E2K99_RS11365	COG0024	Methionine aminopeptidase
E2K99_RS11370	COG0052	Belongs to the universal ribosomal protein uS2 family
E2K99_RS11375	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E2K99_RS11380	COG0528	UMP kinase activity
E2K99_RS11385	COG0233	cytoplasmic translational termination
E2K99_RS11390	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E2K99_RS11395	COG0575	Belongs to the CDS family
E2K99_RS11400	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E2K99_RS11405	COG0750	zinc metalloprotease
E2K99_RS11420	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E2K99_RS11425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E2K99_RS11430	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E2K99_RS11440	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E2K99_RS11445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E2K99_RS11455	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E2K99_RS11475	COG0330	HflC and HflK could
E2K99_RS11485	COG2205	protein histidine kinase activity
E2K99_RS11490	COG0745	RESPONSE REGULATOR receiver
E2K99_RS11505	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E2K99_RS11515	COG2914	Belongs to the UPF0125 (RnfH) family
E2K99_RS11520	COG0517	IMP dehydrogenase activity
E2K99_RS11520	COG0516	GMP reductase activity
E2K99_RS11525	COG0519	Catalyzes the synthesis of GMP from XMP
E2K99_RS11525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E2K99_RS11555	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E2K99_RS11560	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E2K99_RS11575	COG2851	Citrate transporter
E2K99_RS11580	COG0583	DNA-binding transcription factor activity
E2K99_RS11590	COG0784	Response regulator, receiver
E2K99_RS11600	COG2198	Histidine kinase
E2K99_RS11600	COG0643	Histidine kinase
E2K99_RS11605	COG2201	protein-glutamate methylesterase activity
E2K99_RS11610	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E2K99_RS11620	COG2201	protein-glutamate methylesterase activity
E2K99_RS11625	COG0835	chemotaxis
E2K99_RS11630	COG0840	transmembrane signaling receptor activity
E2K99_RS11645	COG2244	polysaccharide biosynthetic process
E2K99_RS11650	COG0463	Glycosyl transferase, family 2
E2K99_RS11660	COG2197	response regulator
E2K99_RS11665	COG0477	Major facilitator Superfamily
E2K99_RS11675	COG1840	ABC-type Fe3 transport system, periplasmic component
E2K99_RS11680	COG4149	molybdate abc transporter
E2K99_RS11685	COG3842	ATPase activity
E2K99_RS11695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2K99_RS11720	COG4181	ATPase activity
E2K99_RS11730	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E2K99_RS11730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E2K99_RS11735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2K99_RS11740	COG0047	phosphoribosylformylglycinamidine synthase activity
E2K99_RS11740	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E2K99_RS11755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2K99_RS11765	COG2917	probably involved in intracellular septation
E2K99_RS11770	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2K99_RS11775	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E2K99_RS11790	COG0411	ABC transporter
E2K99_RS11805	COG1215	transferase activity, transferring glycosyl groups
E2K99_RS11810	COG2271	Major facilitator Superfamily
E2K99_RS11820	COG1012	belongs to the aldehyde dehydrogenase family
E2K99_RS11825	COG2186	Transcriptional regulator
E2K99_RS11835	COG3706	GGDEF domain
E2K99_RS11840	COG0587	DNA-directed DNA polymerase activity
E2K99_RS11870	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
E2K99_RS11890	COG0693	protein deglycase activity
E2K99_RS11905	COG0028	Belongs to the TPP enzyme family
E2K99_RS11910	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
E2K99_RS11920	COG0322	excinuclease ABC activity
E2K99_RS11940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2K99_RS11950	COG1201	RNA secondary structure unwinding
E2K99_RS11955	COG1793	dna ligase
E2K99_RS11960	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E2K99_RS11960	COG1793	dna ligase
E2K99_RS11990	COG1802	Transcriptional regulator
E2K99_RS12000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2K99_RS12005	COG0765	amino acid transport
E2K99_RS12010	COG1126	abc transporter atp-binding protein
E2K99_RS12020	COG0402	S-adenosylhomocysteine deaminase activity
E2K99_RS12035	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E2K99_RS12040	COG1879	ABC-type sugar transport system periplasmic component
E2K99_RS12045	COG1129	ABC transporter
E2K99_RS12050	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2K99_RS12055	COG1609	Transcriptional regulator
E2K99_RS12060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E2K99_RS12065	COG1869	D-ribose catabolic process
E2K99_RS12070	COG0840	transmembrane signaling receptor activity
E2K99_RS12075	COG2982	Protein involved in outer membrane biogenesis
E2K99_RS12085	COG4191	Histidine kinase
E2K99_RS12085	COG0784	Response regulator, receiver
E2K99_RS12115	COG0640	Transcriptional regulator
E2K99_RS12125	COG0583	DNA-binding transcription factor activity
E2K99_RS12130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E2K99_RS12135	COG3002	Belongs to the UPF0753 family
E2K99_RS12140	COG4251	negative regulation of phosphorylation
E2K99_RS12140	COG5001	Diguanylate cyclase
E2K99_RS12140	COG2203	Gaf domain
E2K99_RS12140	COG3706	GGDEF domain
E2K99_RS12150	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
E2K99_RS12150	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
E2K99_RS12180	COG1464	Belongs to the NlpA lipoprotein family
E2K99_RS12200	COG2217	Heavy metal translocating P-type atpase
E2K99_RS12230	COG2132	Multicopper oxidase
E2K99_RS12235	COG0745	RESPONSE REGULATOR receiver
E2K99_RS12240	COG5002	protein histidine kinase activity
E2K99_RS12320	COG2814	Major facilitator Superfamily
E2K99_RS12360	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E2K99_RS12420	COG3093	addiction module antidote protein HigA
E2K99_RS12440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E2K99_RS12445	COG2011	ABC-type metal ion transport system permease component
E2K99_RS12450	COG4106	trans-aconitate 2-methyltransferase activity
E2K99_RS12490	COG5002	protein histidine kinase activity
E2K99_RS12495	COG0745	RESPONSE REGULATOR receiver
E2K99_RS12500	COG2132	Multicopper oxidase
E2K99_RS12530	COG2217	Heavy metal translocating P-type atpase
E2K99_RS12555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2K99_RS12560	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2K99_RS12570	COG2249	NAD(P)H dehydrogenase (quinone) activity
E2K99_RS12575	COG4264	IucA IucC family
E2K99_RS12580	COG2814	Major facilitator Superfamily
E2K99_RS12590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2K99_RS12595	COG0583	DNA-binding transcription factor activity
E2K99_RS12600	COG0626	cystathionine gamma-synthase activity
E2K99_RS12605	COG0765	amino acid transport
E2K99_RS12610	COG1126	abc transporter atp-binding protein
E2K99_RS12650	COG2372	response to copper ion
E2K99_RS12660	COG4774	siderophore transport
E2K99_RS12675	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
E2K99_RS12710	COG4774	siderophore transport
E2K99_RS12720	COG1595	DNA-templated transcription, initiation
E2K99_RS12725	COG4774	siderophore transport
E2K99_RS12735	COG1595	DNA-templated transcription, initiation
E2K99_RS12755	COG0642	Histidine kinase
E2K99_RS12805	COG0583	DNA-binding transcription factor activity
E2K99_RS12820	COG1176	ABC-type spermidine putrescine transport system, permease component I
E2K99_RS12830	COG3842	ATPase activity
E2K99_RS12835	COG1957	nucleoside hydrolase
E2K99_RS12840	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E2K99_RS12845	COG0840	transmembrane signaling receptor activity
E2K99_RS12855	COG2814	Major facilitator Superfamily
E2K99_RS12870	COG2944	sequence-specific DNA binding
E2K99_RS12875	COG0417	DNA replication proofreading
E2K99_RS12890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2K99_RS12895	COG0300	oxidoreductase activity
E2K99_RS12910	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E2K99_RS12915	COG2124	cytochrome p450
E2K99_RS12920	COG0156	8-amino-7-oxononanoate synthase activity
E2K99_RS12930	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E2K99_RS12940	COG4191	Histidine kinase
E2K99_RS12940	COG0784	Response regulator, receiver
E2K99_RS12965	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E2K99_RS12980	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E2K99_RS12985	COG1845	cytochrome c oxidase, subunit III
E2K99_RS12990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E2K99_RS12995	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E2K99_RS13000	COG0477	Major facilitator Superfamily
E2K99_RS13040	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E2K99_RS13045	COG0488	(ABC) transporter
E2K99_RS13055	COG1619	proteins homologs of microcin C7 resistance protein MccF
E2K99_RS13065	COG0720	synthase
E2K99_RS13070	COG0602	queuosine metabolic process
E2K99_RS13090	COG0038	chloride channel
E2K99_RS13110	COG0745	RESPONSE REGULATOR receiver
E2K99_RS13130	COG0643	Histidine kinase
E2K99_RS13130	COG2198	Histidine kinase
E2K99_RS13135	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS13145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2K99_RS13160	COG1309	transcriptional regulator
E2K99_RS13165	COG0681	Belongs to the peptidase S26 family
E2K99_RS13170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2K99_RS13185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2K99_RS13250	COG2204	response regulator
E2K99_RS13255	COG0784	Response regulator, receiver
E2K99_RS13260	COG4251	negative regulation of phosphorylation
E2K99_RS13270	COG0166	Belongs to the GPI family
E2K99_RS13280	COG1640	4-alpha-glucanotransferase
E2K99_RS13285	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E2K99_RS13295	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E2K99_RS13300	COG0297	glycogen (starch) synthase activity
E2K99_RS13305	COG3360	Dodecin
E2K99_RS13315	COG3604	Transcriptional regulator
E2K99_RS13330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E2K99_RS13345	COG4453	Protein conserved in bacteria
E2K99_RS13355	COG4302	ethanolamine ammonia-lyase activity
E2K99_RS13370	COG0531	amino acid
E2K99_RS13385	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
E2K99_RS13400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2K99_RS13405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2K99_RS13405	COG1116	anion transmembrane transporter activity
E2K99_RS13415	COG0642	Histidine kinase
E2K99_RS13425	COG2264	protein methyltransferase activity
E2K99_RS13435	COG1396	sequence-specific DNA binding
E2K99_RS13440	COG3550	peptidyl-serine autophosphorylation
E2K99_RS13445	COG1741	Belongs to the pirin family
E2K99_RS13460	COG0583	DNA-binding transcription factor activity
E2K99_RS13470	COG3550	peptidyl-serine autophosphorylation
E2K99_RS13475	COG4977	sequence-specific DNA binding
E2K99_RS13480	COG2814	Major facilitator Superfamily
E2K99_RS13490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E2K99_RS13495	COG0671	phosphoesterase, PA-phosphatase related
E2K99_RS13500	COG1597	lipid kinase activity
E2K99_RS13520	COG0523	cobalamin synthesis protein
E2K99_RS13525	COG1469	GTP cyclohydrolase I activity
E2K99_RS13550	COG1024	Enoyl-CoA hydratase
E2K99_RS13555	COG1960	acyl-CoA dehydrogenase activity
E2K99_RS13565	COG4251	negative regulation of phosphorylation
E2K99_RS13565	COG2203	Gaf domain
E2K99_RS13565	COG5001	Diguanylate cyclase
E2K99_RS13565	COG3706	GGDEF domain
E2K99_RS13575	COG0583	DNA-binding transcription factor activity
E2K99_RS13580	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS13600	COG0625	glutathione transferase activity
E2K99_RS13615	COG0436	Aminotransferase
E2K99_RS13655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E2K99_RS13665	COG2197	response regulator
E2K99_RS13670	COG4585	Histidine kinase
E2K99_RS13675	COG3852	Histidine kinase
E2K99_RS13695	COG3188	usher protein
E2K99_RS13710	COG0567	Dehydrogenase, E1 component
E2K99_RS13715	COG0840	transmembrane signaling receptor activity
E2K99_RS13735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E2K99_RS13740	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E2K99_RS13750	COG0740	serine-type endopeptidase activity
E2K99_RS13755	COG0544	peptidyl-prolyl cis-trans isomerase activity
E2K99_RS13760	COG3045	CreA protein
E2K99_RS13815	COG1304	FMN binding
E2K99_RS13825	COG0084	hydrolase, TatD family'
E2K99_RS13830	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E2K99_RS13835	COG4191	Histidine kinase
E2K99_RS13845	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E2K99_RS13850	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E2K99_RS13870	COG0584	glycerophosphoryl diester phosphodiesterase
E2K99_RS13875	COG3511	phospholipase C
E2K99_RS13880	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E2K99_RS13885	COG0848	biopolymer transport protein
E2K99_RS13890	COG0811	peptide transport
E2K99_RS13900	COG1609	Transcriptional regulator
E2K99_RS13905	COG1653	transport
E2K99_RS13915	COG0395	ABC-type sugar transport system, permease component
E2K99_RS13930	COG3311	Transcriptional regulator
E2K99_RS13935	COG1569	PIN domain
E2K99_RS13940	COG1301	dicarboxylic acid transport
E2K99_RS13965	COG0583	DNA-binding transcription factor activity
E2K99_RS13970	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E2K99_RS13975	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E2K99_RS13985	COG1454	alcohol dehydrogenase
E2K99_RS13995	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E2K99_RS14055	COG2198	Histidine kinase
E2K99_RS14055	COG0784	Response regulator, receiver
E2K99_RS14055	COG5002	protein histidine kinase activity
E2K99_RS14060	COG0745	RESPONSE REGULATOR receiver
E2K99_RS14065	COG0659	secondary active sulfate transmembrane transporter activity
E2K99_RS14080	COG1492	cobalamin metabolic process
E2K99_RS14100	COG0778	Nitroreductase
E2K99_RS14140	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E2K99_RS14150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E2K99_RS14150	COG1648	precorrin-2 dehydrogenase activity
E2K99_RS14165	COG3411	Ferredoxin
E2K99_RS14210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E2K99_RS14225	COG0633	Ferredoxin
E2K99_RS14225	COG3217	Mosc domain protein beta barrel domain protein
E2K99_RS14240	COG1607	acyl-coa hydrolase
E2K99_RS14245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E2K99_RS14285	COG3052	prosthetic group binding
E2K99_RS14305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E2K99_RS14310	COG1802	Transcriptional regulator
E2K99_RS14320	COG3550	peptidyl-serine autophosphorylation
E2K99_RS14395	COG1566	PFAM secretion protein HlyD family protein
E2K99_RS14400	COG2814	Major facilitator Superfamily
E2K99_RS14405	COG0583	DNA-binding transcription factor activity
E2K99_RS14410	COG0667	Aldo Keto reductase
E2K99_RS14425	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E2K99_RS14430	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E2K99_RS14445	COG0667	Aldo Keto reductase
E2K99_RS14455	COG2824	Alkylphosphonate utilization operon protein PhnA
E2K99_RS14465	COG0672	)-iron permease
E2K99_RS14470	COG4633	Protein conserved in bacteria
E2K99_RS14480	COG0840	transmembrane signaling receptor activity
E2K99_RS14520	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E2K99_RS14525	COG0148	phosphopyruvate hydratase activity
E2K99_RS14530	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E2K99_RS14535	COG0504	CTP synthase activity
E2K99_RS14550	COG0084	hydrolase, TatD family'
E2K99_RS14560	COG1136	(ABC) transporter
E2K99_RS14565	COG4591	ABC-type transport system involved in lipoprotein release permease component
E2K99_RS14570	COG0210	DNA helicase
E2K99_RS14580	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E2K99_RS14605	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E2K99_RS14640	COG0583	DNA-binding transcription factor activity
E2K99_RS14645	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E2K99_RS14675	COG1960	acyl-CoA dehydrogenase activity
E2K99_RS14680	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
E2K99_RS14685	COG0583	DNA-binding transcription factor activity
E2K99_RS14695	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS14710	COG3300	MHYT domain
E2K99_RS14710	COG5001	Diguanylate cyclase
E2K99_RS14725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2K99_RS14730	COG2274	protein secretion by the type I secretion system
E2K99_RS14770	COG3733	amine oxidase
E2K99_RS14780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E2K99_RS14800	COG0583	DNA-binding transcription factor activity
E2K99_RS14805	COG1346	cytolysis
E2K99_RS14825	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E2K99_RS14835	COG1215	transferase activity, transferring glycosyl groups
E2K99_RS14855	COG1881	PFAM PEBP family protein
E2K99_RS14870	COG1285	pathogenesis
E2K99_RS14875	COG1742	UPF0060 membrane protein
E2K99_RS14880	COG2223	nitrite transmembrane transporter activity
E2K99_RS14885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2K99_RS14890	COG2146	nitrite reductase [NAD(P)H] activity
E2K99_RS14895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2K99_RS14900	COG0243	molybdopterin cofactor binding
E2K99_RS14935	COG0840	transmembrane signaling receptor activity
E2K99_RS14940	COG0840	transmembrane signaling receptor activity
E2K99_RS14950	COG3064	Membrane
E2K99_RS14960	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E2K99_RS14970	COG2959	enzyme of heme biosynthesis
E2K99_RS14980	COG0181	hydroxymethylbilane synthase activity
E2K99_RS14985	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E2K99_RS15005	COG0165	Argininosuccinate lyase
E2K99_RS15060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2K99_RS15065	COG0235	Class ii aldolase
E2K99_RS15075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2K99_RS15100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E2K99_RS15110	COG0583	DNA-binding transcription factor activity
E2K99_RS15115	COG2814	Major facilitator Superfamily
E2K99_RS15125	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E2K99_RS15130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E2K99_RS15135	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E2K99_RS15140	COG0330	HflC and HflK could
E2K99_RS15145	COG0330	HflC and HflK could
E2K99_RS15150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E2K99_RS15155	COG1923	regulation of RNA biosynthetic process
E2K99_RS15160	COG1160	GTP binding
E2K99_RS15175	COG0124	histidyl-tRNA synthetase
E2K99_RS15180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E2K99_RS15190	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E2K99_RS15195	COG0105	UTP biosynthetic process
E2K99_RS15210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E2K99_RS15215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E2K99_RS15220	COG1388	LysM domain
E2K99_RS15220	COG4942	peptidase
E2K99_RS15225	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E2K99_RS15230	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E2K99_RS15240	COG1199	ATP-dependent helicase activity
E2K99_RS15255	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E2K99_RS15260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2K99_RS15265	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2K99_RS15270	COG0567	Dehydrogenase, E1 component
E2K99_RS15275	COG0372	Belongs to the citrate synthase family
E2K99_RS15280	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E2K99_RS15285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E2K99_RS15290	COG1053	succinate dehydrogenase
E2K99_RS15305	COG2188	Transcriptional regulator
E2K99_RS15310	COG0039	L-malate dehydrogenase activity
E2K99_RS15325	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E2K99_RS15335	COG0835	chemotaxis
E2K99_RS15345	COG0745	RESPONSE REGULATOR receiver
E2K99_RS15355	COG1360	Flagellar Motor Protein
E2K99_RS15380	COG0626	cystathionine gamma-synthase activity
E2K99_RS15390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E2K99_RS15400	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS15405	COG3243	poly(R)-hydroxyalkanoic acid synthase
E2K99_RS15435	COG0564	pseudouridine synthase activity
E2K99_RS15450	COG3022	response to hydroperoxide
E2K99_RS15470	COG0436	Aminotransferase
E2K99_RS15475	COG0625	glutathione transferase activity
E2K99_RS15480	COG3447	MASE1 domain protein
E2K99_RS15480	COG5002	protein histidine kinase activity
E2K99_RS15480	COG5001	Diguanylate cyclase
E2K99_RS15490	COG4251	negative regulation of phosphorylation
E2K99_RS15490	COG3706	GGDEF domain
E2K99_RS15490	COG2203	Gaf domain
E2K99_RS15490	COG5001	Diguanylate cyclase
E2K99_RS15495	COG2201	protein-glutamate methylesterase activity
E2K99_RS15520	COG0840	transmembrane signaling receptor activity
E2K99_RS15530	COG0560	Phosphoserine phosphatase
E2K99_RS15535	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E2K99_RS15540	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E2K99_RS15545	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E2K99_RS15550	COG1278	Cold shock
E2K99_RS15555	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E2K99_RS15560	COG0583	DNA-binding transcription factor activity
E2K99_RS15570	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E2K99_RS15590	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E2K99_RS15595	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E2K99_RS15600	COG0840	transmembrane signaling receptor activity
E2K99_RS15625	COG2814	Major facilitator Superfamily
E2K99_RS15660	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E2K99_RS15675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2K99_RS15680	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E2K99_RS15685	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E2K99_RS15700	COG0628	permease
E2K99_RS15720	COG1294	oxidase, subunit
E2K99_RS15735	COG1764	response to oxidative stress
E2K99_RS15740	COG1846	Transcriptional regulator
E2K99_RS15750	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E2K99_RS15755	COG2186	Transcriptional regulator
E2K99_RS15760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2K99_RS15780	COG0583	DNA-binding transcription factor activity
E2K99_RS15800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2K99_RS15805	COG1024	Enoyl-CoA hydratase
E2K99_RS15850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E2K99_RS15855	COG0489	protein tyrosine kinase activity
E2K99_RS15860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2K99_RS15860	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2K99_RS15870	COG2390	Transcriptional regulator
E2K99_RS15875	COG3842	ATPase activity
E2K99_RS15885	COG1175	transmembrane transport
E2K99_RS15890	COG0395	ABC-type sugar transport system, permease component
E2K99_RS15905	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E2K99_RS15910	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E2K99_RS15915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E2K99_RS15930	COG1120	ATPase activity
E2K99_RS15940	COG4774	siderophore transport
E2K99_RS15945	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E2K99_RS15950	COG0643	Histidine kinase
E2K99_RS15950	COG2198	Histidine kinase
E2K99_RS15950	COG0784	Response regulator, receiver
E2K99_RS15955	COG0583	DNA-binding transcription factor activity
E2K99_RS15960	COG0730	response to heat
E2K99_RS15965	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2K99_RS15975	COG0175	sulfate reduction
E2K99_RS15985	COG2895	sulfate adenylyltransferase (ATP) activity
E2K99_RS15995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2K99_RS16005	COG0795	lipopolysaccharide-transporting ATPase activity
E2K99_RS16010	COG0795	lipopolysaccharide-transporting ATPase activity
E2K99_RS16015	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E2K99_RS16025	COG1902	pentaerythritol trinitrate reductase activity
E2K99_RS16040	COG0708	Exodeoxyribonuclease III
E2K99_RS16050	COG1247	-acetyltransferase
E2K99_RS16085	COG0840	transmembrane signaling receptor activity
E2K99_RS16090	COG2204	response regulator
E2K99_RS16095	COG3852	Histidine kinase
E2K99_RS16100	COG0174	glutamine synthetase
E2K99_RS16110	COG0784	Response regulator, receiver
E2K99_RS16110	COG2205	protein histidine kinase activity
E2K99_RS16130	COG2975	iron-sulfur cluster assembly
E2K99_RS16140	COG0443	Heat shock 70 kDa protein
E2K99_RS16150	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E2K99_RS16155	COG0316	Belongs to the HesB IscA family
E2K99_RS16160	COG0822	iron-sulfur transferase activity
E2K99_RS16165	COG1104	cysteine desulfurase activity
E2K99_RS16175	COG2186	Transcriptional regulator
E2K99_RS16180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2K99_RS16190	COG2706	6-phosphogluconolactonase activity
E2K99_RS16195	COG2721	sulfolactate sulfo-lyase activity
E2K99_RS16200	COG2271	Major facilitator Superfamily
E2K99_RS16205	COG0701	Predicted permease
E2K99_RS16210	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E2K99_RS16215	COG0709	Synthesizes selenophosphate from selenide and ATP
E2K99_RS16245	COG0556	nucleotide-excision repair
E2K99_RS16265	COG0583	DNA-binding transcription factor activity
E2K99_RS16275	COG0803	Belongs to the bacterial solute-binding protein 9 family
E2K99_RS16280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E2K99_RS16295	COG1136	(ABC) transporter
E2K99_RS16320	COG1473	amidohydrolase
E2K99_RS16325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2K99_RS16330	COG4608	Belongs to the ABC transporter superfamily
E2K99_RS16335	COG0444	Belongs to the ABC transporter superfamily
E2K99_RS16340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2K99_RS16350	COG0747	negative chemotaxis
E2K99_RS16355	COG0583	DNA-binding transcription factor activity
E2K99_RS16395	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E2K99_RS16400	COG3047	cAMP biosynthetic process
E2K99_RS16410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E2K99_RS16445	COG3278	Belongs to the heme-copper respiratory oxidase family
E2K99_RS16455	COG2217	Heavy metal translocating P-type atpase
E2K99_RS16465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E2K99_RS16500	COG0697	spore germination
E2K99_RS16505	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E2K99_RS16510	COG2814	Major facilitator Superfamily
E2K99_RS16515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2K99_RS16530	COG3706	GGDEF domain
E2K99_RS16530	COG4251	negative regulation of phosphorylation
E2K99_RS16530	COG2203	Gaf domain
E2K99_RS16530	COG5001	Diguanylate cyclase
E2K99_RS16570	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E2K99_RS16575	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E2K99_RS16580	COG0167	dihydroorotate dehydrogenase activity
E2K99_RS16610	COG0840	transmembrane signaling receptor activity
E2K99_RS16615	COG2199	diguanylate cyclase activity
E2K99_RS16615	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E2K99_RS16625	COG4944	Protein of unknown function (DUF1109)
E2K99_RS16630	COG1595	DNA-templated transcription, initiation
E2K99_RS16645	COG3220	belongs to the UPF0276 family
E2K99_RS16675	COG0583	DNA-binding transcription factor activity
E2K99_RS16715	COG3128	pkhd-type hydroxylase
E2K99_RS16720	COG2986	histidine ammonia-lyase
E2K99_RS16730	COG0583	DNA-binding transcription factor activity
E2K99_RS16735	COG2233	PERMEase
E2K99_RS16750	COG0840	transmembrane signaling receptor activity
E2K99_RS16765	COG0469	pyruvate kinase activity
E2K99_RS16770	COG2084	Dehydrogenase
E2K99_RS16775	COG3622	Belongs to the hyi family
E2K99_RS16780	COG3960	tartronate-semialdehyde synthase activity
E2K99_RS16785	COG0583	DNA-binding transcription factor activity
E2K99_RS16790	COG2252	PERMEase
E2K99_RS16800	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E2K99_RS16810	COG0402	S-adenosylhomocysteine deaminase activity
E2K99_RS16825	COG1566	PFAM secretion protein HlyD family protein
E2K99_RS16830	COG2814	Major facilitator Superfamily
E2K99_RS16835	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E2K99_RS16845	COG1047	Peptidyl-prolyl cis-trans
E2K99_RS16850	COG2850	peptidyl-arginine hydroxylation
E2K99_RS16865	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E2K99_RS16870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2K99_RS16875	COG0180	Tryptophanyl-tRNA synthetase
E2K99_RS16880	COG1994	Peptidase M50
E2K99_RS16885	COG0009	L-threonylcarbamoyladenylate synthase
E2K99_RS16890	COG0501	Belongs to the peptidase M48B family
E2K99_RS16895	COG0613	PHP domain protein
E2K99_RS16900	COG0596	Alpha beta hydrolase
E2K99_RS16915	COG0626	cystathionine gamma-synthase activity
E2K99_RS16925	COG1286	toxin biosynthetic process
E2K99_RS16935	COG0285	dihydrofolate synthase activity
E2K99_RS16940	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E2K99_RS16945	COG0159	tryptophan synthase activity
E2K99_RS16950	COG0133	tryptophan synthase activity
E2K99_RS16955	COG0135	phosphoribosylanthranilate isomerase activity
E2K99_RS16960	COG0101	tRNA pseudouridine synthase activity
E2K99_RS16975	COG0473	3-isopropylmalate dehydrogenase activity
E2K99_RS16980	COG0066	3-isopropylmalate dehydratase activity
E2K99_RS16990	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E2K99_RS16995	COG4783	chaperone-mediated protein folding
E2K99_RS17000	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E2K99_RS17005	COG2814	Major facilitator Superfamily
E2K99_RS17020	COG1295	ribonuclease BN
E2K99_RS17040	COG0277	FAD linked oxidase domain protein
E2K99_RS17060	COG1178	ABC-type Fe3 transport system permease component
E2K99_RS17065	COG3842	ATPase activity
E2K99_RS17090	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
E2K99_RS17095	COG1116	anion transmembrane transporter activity
E2K99_RS17100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2K99_RS17105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2K99_RS17105	COG1116	anion transmembrane transporter activity
E2K99_RS17125	COG2186	Transcriptional regulator
E2K99_RS17135	COG1473	amidohydrolase
E2K99_RS17155	COG2814	Major facilitator Superfamily
E2K99_RS17160	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
E2K99_RS17175	COG0583	DNA-binding transcription factor activity
E2K99_RS17185	COG0457	Tetratricopeptide repeat
E2K99_RS17205	COG2814	Major facilitator Superfamily
E2K99_RS17215	COG0583	DNA-binding transcription factor activity
E2K99_RS17230	COG0025	NhaP-type Na H and K H
E2K99_RS17270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E2K99_RS17275	COG0791	NLP P60 protein
E2K99_RS17280	COG2186	Transcriptional regulator
E2K99_RS17315	COG3842	ATPase activity
E2K99_RS17330	COG3833	ABC-type maltose transport systems, permease component
E2K99_RS17360	COG4269	membrane
E2K99_RS17390	COG0789	Transcriptional regulator
E2K99_RS17395	COG0667	Aldo Keto reductase
E2K99_RS17420	COG2204	response regulator
E2K99_RS17430	COG0477	Major facilitator Superfamily
E2K99_RS17445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E2K99_RS17450	COG1546	Belongs to the CinA family
E2K99_RS17455	COG0284	orotidine-5'-phosphate decarboxylase activity
E2K99_RS17460	COG1704	LemA family
E2K99_RS17480	COG2027	D-alanyl-D-alanine carboxypeptidase
E2K99_RS17485	COG3706	GGDEF domain
E2K99_RS17495	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E2K99_RS17520	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2K99_RS17535	COG0252	asparaginase activity
E2K99_RS17550	COG0515	serine threonine protein kinase
E2K99_RS17550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E2K99_RS17555	COG1309	transcriptional regulator
E2K99_RS17580	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E2K99_RS17585	COG2205	protein histidine kinase activity
E2K99_RS17585	COG0784	Response regulator, receiver
E2K99_RS17585	COG2198	Histidine kinase
E2K99_RS17605	COG0642	Histidine kinase
E2K99_RS17615	COG4774	siderophore transport
E2K99_RS17620	COG3128	pkhd-type hydroxylase
E2K99_RS17630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2K99_RS17640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2K99_RS17645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2K99_RS17670	COG3833	ABC-type maltose transport systems, permease component
E2K99_RS17675	COG1063	alcohol dehydrogenase
E2K99_RS17680	COG3842	ATPase activity
E2K99_RS17685	COG4977	sequence-specific DNA binding
E2K99_RS17685	COG1917	Cupin 2, conserved barrel domain protein
E2K99_RS17690	COG1070	Carbohydrate kinase
E2K99_RS17710	COG0328	RNA-DNA hybrid ribonuclease activity
E2K99_RS17715	COG2226	methyltransferase
E2K99_RS17720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E2K99_RS17730	COG0741	lytic transglycosylase activity
E2K99_RS17730	COG1388	LysM domain
E2K99_RS17735	COG4172	Belongs to the ABC transporter superfamily
E2K99_RS17740	COG4239	(ABC) transporter, permease
E2K99_RS17745	COG4174	ABC transporter (Permease)
E2K99_RS17750	COG4166	transmembrane transport
E2K99_RS17760	COG0513	Belongs to the DEAD box helicase family
E2K99_RS17770	COG3008	intermembrane lipid transfer
E2K99_RS17770	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E2K99_RS17775	COG2995	paraquat-inducible protein a
E2K99_RS17780	COG2995	paraquat-inducible protein a
E2K99_RS17785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2K99_RS17790	COG0840	transmembrane signaling receptor activity
E2K99_RS17795	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E2K99_RS17800	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
E2K99_RS17805	COG1132	(ABC) transporter
E2K99_RS17810	COG1902	pentaerythritol trinitrate reductase activity
E2K99_RS17815	COG0586	Pfam SNARE associated Golgi protein
E2K99_RS17820	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS17825	COG3246	L-lysine catabolic process to acetate
E2K99_RS17850	COG3416	Protein conserved in bacteria
E2K99_RS17850	COG2943	transferase activity, transferring hexosyl groups
E2K99_RS17855	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
E2K99_RS17860	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E2K99_RS17885	COG0717	Belongs to the dCTP deaminase family
E2K99_RS17900	COG1643	Atp-dependent helicase
E2K99_RS17905	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E2K99_RS17905	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E2K99_RS17910	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E2K99_RS17915	COG0612	Peptidase, M16
E2K99_RS17925	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E2K99_RS17930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E2K99_RS17930	COG4651	solute:proton antiporter activity
E2K99_RS17935	COG1522	sequence-specific DNA binding
E2K99_RS17970	COG2171	N-acyltransferase activity
E2K99_RS17995	COG1280	lysine exporter protein (LysE YggA)
E2K99_RS18000	COG0784	Response regulator, receiver
E2K99_RS18045	COG0840	transmembrane signaling receptor activity
E2K99_RS18065	COG4251	negative regulation of phosphorylation
E2K99_RS18065	COG2203	Gaf domain
E2K99_RS18065	COG3706	GGDEF domain
E2K99_RS18065	COG5001	Diguanylate cyclase
E2K99_RS18075	COG0308	aminopeptidase N
E2K99_RS18100	COG0697	spore germination
E2K99_RS18105	COG0433	COG0433 Predicted ATPase
E2K99_RS18110	COG0217	transcriptional regulatory protein
E2K99_RS18115	COG0151	Belongs to the GarS family
E2K99_RS18120	COG0668	transmembrane transport
E2K99_RS18125	COG0408	coproporphyrinogen oxidase activity
E2K99_RS18130	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E2K99_RS18135	COG0799	negative regulation of ribosome biogenesis
E2K99_RS18140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E2K99_RS18145	COG0424	maF-like protein
E2K99_RS18175	COG0859	PFAM glycosyl transferase family 9
E2K99_RS18180	COG1132	(ABC) transporter
E2K99_RS18195	COG1054	Belongs to the UPF0176 family
E2K99_RS18205	COG1741	Belongs to the pirin family
E2K99_RS18210	COG0583	DNA-binding transcription factor activity
E2K99_RS18215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E2K99_RS18220	COG0513	Belongs to the DEAD box helicase family
E2K99_RS18245	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E2K99_RS18255	COG0436	Aminotransferase
E2K99_RS18260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E2K99_RS18265	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E2K99_RS18285	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E2K99_RS18290	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E2K99_RS18295	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E2K99_RS18305	COG0779	Required for maturation of 30S ribosomal subunits
E2K99_RS18310	COG1187	pseudouridine synthase activity
E2K99_RS18315	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E2K99_RS18325	COG0069	glutamate synthase activity
E2K99_RS18330	COG0425	Belongs to the sulfur carrier protein TusA family
E2K99_RS18335	COG0494	nUDIX hydrolase
E2K99_RS18340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E2K99_RS18350	COG0584	glycerophosphoryl diester phosphodiesterase
E2K99_RS18360	COG2972	Histidine kinase
E2K99_RS18365	COG3279	Response regulator of the LytR AlgR family
E2K99_RS18370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E2K99_RS18390	COG2233	PERMEase
E2K99_RS18400	COG2329	Antibiotic biosynthesis monooxygenase
E2K99_RS18415	COG2925	Exonuclease
E2K99_RS18425	COG1695	Transcriptional regulator
E2K99_RS18440	COG1960	acyl-CoA dehydrogenase activity
E2K99_RS18445	COG2321	neutral zinc metallopeptidase
E2K99_RS18460	COG2501	S4 domain
E2K99_RS18495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E2K99_RS18495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E2K99_RS18540	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E2K99_RS18545	COG4638	Rieske (2fe-2S)
E2K99_RS18580	COG2199	diguanylate cyclase activity
E2K99_RS18580	COG2200	EAL domain
E2K99_RS18580	COG2202	Pas domain
E2K99_RS18585	COG3121	Chaperone
E2K99_RS18595	COG3121	Chaperone
E2K99_RS18675	COG1501	Belongs to the glycosyl hydrolase 31 family
E2K99_RS18680	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E2K99_RS18685	COG1012	belongs to the aldehyde dehydrogenase family
E2K99_RS18700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2K99_RS18710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2K99_RS18715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2K99_RS18720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E2K99_RS18730	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E2K99_RS18735	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E2K99_RS18740	COG3706	GGDEF domain
E2K99_RS18750	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E2K99_RS18760	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E2K99_RS18770	COG0776	regulation of translation
E2K99_RS18780	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E2K99_RS18795	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E2K99_RS18810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E2K99_RS18840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E2K99_RS18845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E2K99_RS18870	COG2986	histidine ammonia-lyase
E2K99_RS18895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E2K99_RS18905	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS18910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E2K99_RS18930	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E2K99_RS18940	COG3485	protocatechuate 3,4-dioxygenase
E2K99_RS18960	COG3046	protein related to deoxyribodipyrimidine photolyase
E2K99_RS18970	COG2205	protein histidine kinase activity
E2K99_RS18970	COG0784	Response regulator, receiver
E2K99_RS18970	COG2198	Histidine kinase
E2K99_RS18985	COG0840	transmembrane signaling receptor activity
E2K99_RS18990	COG0784	Response regulator, receiver
E2K99_RS18990	COG0835	chemotaxis
E2K99_RS19000	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E2K99_RS19005	COG0840	transmembrane signaling receptor activity
E2K99_RS19010	COG4191	Histidine kinase
E2K99_RS19030	COG4566	intracellular signal transduction
E2K99_RS19070	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS19095	COG0745	RESPONSE REGULATOR receiver
E2K99_RS19110	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E2K99_RS19145	COG1082	Xylose isomerase domain protein TIM barrel
E2K99_RS19145	COG3185	4-Hydroxyphenylpyruvate dioxygenase
E2K99_RS19160	COG1414	Transcriptional regulator
E2K99_RS19165	COG1414	Transcriptional regulator
E2K99_RS19170	COG0778	Nitroreductase
E2K99_RS19175	COG0583	DNA-binding transcription factor activity
E2K99_RS19185	COG0840	transmembrane signaling receptor activity
E2K99_RS19200	COG1116	anion transmembrane transporter activity
E2K99_RS19220	COG1024	Enoyl-CoA hydratase
E2K99_RS19265	COG0745	RESPONSE REGULATOR receiver
E2K99_RS19270	COG2205	protein histidine kinase activity
E2K99_RS19275	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
E2K99_RS19280	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E2K99_RS19285	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E2K99_RS19350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2K99_RS19355	COG2130	NADP-dependent
E2K99_RS19360	COG1309	transcriptional regulator
E2K99_RS19370	COG4977	sequence-specific DNA binding
E2K99_RS19375	COG1408	metallophosphoesterase
E2K99_RS19390	COG0583	DNA-binding transcription factor activity
E2K99_RS19405	COG3842	ATPase activity
E2K99_RS19410	COG0395	ABC-type sugar transport system, permease component
E2K99_RS19415	COG1175	transmembrane transport
E2K99_RS19425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E2K99_RS19430	COG0500	methyltransferase
E2K99_RS19460	COG0386	Belongs to the glutathione peroxidase family
E2K99_RS19465	COG2105	PFAM AIG2 family protein
E2K99_RS19470	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E2K99_RS19480	COG3284	Transcriptional regulator
E2K99_RS19485	COG0583	DNA-binding transcription factor activity
E2K99_RS19505	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS19520	COG0183	Belongs to the thiolase family
E2K99_RS19545	COG3511	phospholipase C
E2K99_RS19550	COG0247	lactate metabolic process
E2K99_RS19555	COG0277	FAD linked oxidase domain protein
E2K99_RS19560	COG0277	FAD linked oxidase domain protein
E2K99_RS19565	COG0583	DNA-binding transcription factor activity
E2K99_RS19570	COG0277	FAD linked oxidase domain protein
E2K99_RS19575	COG2096	Adenosyltransferase
E2K99_RS19595	COG0142	geranyltranstransferase activity
E2K99_RS19600	COG1722	exodeoxyribonuclease VII activity
E2K99_RS19630	COG0643	Histidine kinase
E2K99_RS19630	COG2198	Histidine kinase
E2K99_RS19635	COG0840	transmembrane signaling receptor activity
E2K99_RS19640	COG0835	chemotaxis
E2K99_RS19645	COG1773	rubredoxin
E2K99_RS19655	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E2K99_RS19660	COG0316	Belongs to the HesB IscA family
E2K99_RS19675	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E2K99_RS19680	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E2K99_RS19685	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E2K99_RS19700	COG0418	dihydroorotase activity
E2K99_RS19705	COG1126	abc transporter atp-binding protein
E2K99_RS19710	COG0765	amino acid transport
E2K99_RS19715	COG0765	amino acid transport
E2K99_RS19725	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E2K99_RS19735	COG5265	(ABC) transporter
E2K99_RS19745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E2K99_RS19800	COG0318	PFAM AMP-dependent synthetase and ligase
E2K99_RS19810	COG0243	molybdopterin cofactor binding
E2K99_RS19825	COG1473	amidohydrolase
E2K99_RS19865	COG0765	amino acid transport
E2K99_RS19870	COG1126	abc transporter atp-binding protein
E2K99_RS19880	COG2721	sulfolactate sulfo-lyase activity
E2K99_RS19890	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS19900	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E2K99_RS19955	COG1024	Enoyl-CoA hydratase
E2K99_RS19965	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E2K99_RS19975	COG2967	ApaG domain
E2K99_RS19980	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E2K99_RS19985	COG0546	phosphoglycolate phosphatase activity
E2K99_RS19995	COG0512	Glutamine amidotransferase of anthranilate synthase
E2K99_RS20000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E2K99_RS20005	COG0134	indole-3-glycerol-phosphate synthase activity
E2K99_RS20010	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS20015	COG0583	DNA-binding transcription factor activity
E2K99_RS20020	COG0477	Major facilitator Superfamily
E2K99_RS20025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E2K99_RS20040	COG2226	methyltransferase
E2K99_RS20045	COG1247	-acetyltransferase
E2K99_RS20065	COG1238	metal cluster binding
E2K99_RS20070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E2K99_RS20075	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E2K99_RS20075	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E2K99_RS20090	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E2K99_RS20095	COG1660	Displays ATPase and GTPase activities
E2K99_RS20100	COG1194	a g-specific adenine glycosylase
E2K99_RS20105	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E2K99_RS20115	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E2K99_RS20120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E2K99_RS20130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E2K99_RS20135	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E2K99_RS20150	COG0070	glutamate synthase
E2K99_RS20150	COG0069	glutamate synthase activity
E2K99_RS20150	COG0067	glutamate synthase
E2K99_RS20160	COG0861	Integral membrane protein TerC family
E2K99_RS20170	COG0583	DNA-binding transcription factor activity
E2K99_RS20180	COG0477	Major facilitator Superfamily
E2K99_RS20185	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E2K99_RS20195	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
E2K99_RS20210	COG3038	cytochrome b561
E2K99_RS20240	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E2K99_RS20255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2K99_RS20290	COG0028	Belongs to the TPP enzyme family
E2K99_RS20300	COG2207	Transcriptional regulator
E2K99_RS20305	COG1012	belongs to the aldehyde dehydrogenase family
E2K99_RS20325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2K99_RS20330	COG0745	RESPONSE REGULATOR receiver
E2K99_RS20335	COG5002	protein histidine kinase activity
E2K99_RS20410	COG2194	sulfuric ester hydrolase activity
E2K99_RS20465	COG2814	Major facilitator Superfamily
E2K99_RS20525	COG5002	protein histidine kinase activity
E2K99_RS20530	COG0745	RESPONSE REGULATOR receiver
E2K99_RS20535	COG2132	Multicopper oxidase
E2K99_RS20565	COG2217	Heavy metal translocating P-type atpase
E2K99_RS20610	COG0629	single-stranded DNA binding
E2K99_RS20615	COG2814	Major facilitator Superfamily
E2K99_RS20630	COG5285	phytanoyl-CoA dioxygenase
E2K99_RS20635	COG0840	transmembrane signaling receptor activity
E2K99_RS20655	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E2K99_RS20665	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E2K99_RS20670	COG1137	ATPase activity
E2K99_RS20675	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E2K99_RS20680	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E2K99_RS20685	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E2K99_RS20695	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS20705	COG1522	sequence-specific DNA binding
E2K99_RS20720	COG2207	Transcriptional regulator
E2K99_RS20720	COG3708	Transcriptional regulator
E2K99_RS20730	COG0259	pyridoxamine-phosphate oxidase activity
E2K99_RS20745	COG1414	Transcriptional regulator
E2K99_RS20750	COG3485	protocatechuate 3,4-dioxygenase
E2K99_RS20755	COG3485	protocatechuate 3,4-dioxygenase
E2K99_RS20760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E2K99_RS20765	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E2K99_RS20810	COG0411	ABC transporter
E2K99_RS20815	COG4177	L-phenylalanine transmembrane transporter activity
E2K99_RS20825	COG0183	Belongs to the thiolase family
E2K99_RS20830	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E2K99_RS20840	COG1414	Transcriptional regulator
E2K99_RS20855	COG0683	leucine binding
E2K99_RS20860	COG1024	Enoyl-CoA hydratase
E2K99_RS20865	COG1022	Amp-dependent synthetase and ligase
E2K99_RS20870	COG0183	Belongs to the thiolase family
E2K99_RS20910	COG1960	acyl-CoA dehydrogenase activity
E2K99_RS20925	COG0840	transmembrane signaling receptor activity
E2K99_RS21005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E2K99_RS21100	COG1944	ATP diphosphatase activity
E2K99_RS21110	COG2969	positive regulation of protein catabolic process
E2K99_RS21115	COG0625	glutathione transferase activity
E2K99_RS21120	COG2857	Cytochrome c1
E2K99_RS21125	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E2K99_RS21130	COG0723	plastoquinol--plastocyanin reductase activity
E2K99_RS21135	COG1970	mechanosensitive ion channel activity
E2K99_RS21140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E2K99_RS21155	COG0805	protein transport
E2K99_RS21160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E2K99_RS21165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E2K99_RS21175	COG0140	phosphoribosyl-ATP diphosphatase activity
E2K99_RS21180	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E2K99_RS21185	COG0107	imidazoleglycerol-phosphate synthase activity
E2K99_RS21190	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E2K99_RS21200	COG0131	Imidazoleglycerol-phosphate dehydratase
E2K99_RS21205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E2K99_RS21215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E2K99_RS21220	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E2K99_RS21225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E2K99_RS21230	COG0271	Belongs to the BolA IbaG family
E2K99_RS21235	COG0842	Transport permease protein
E2K99_RS21240	COG1131	(ABC) transporter
E2K99_RS21255	COG2853	Lipoprotein
E2K99_RS21260	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E2K99_RS21265	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E2K99_RS21270	COG1127	ABC transporter
E2K99_RS21275	COG0012	GTP binding
E2K99_RS21295	COG0511	ligase activity, forming carbon-carbon bonds
E2K99_RS21300	COG0439	Biotin carboxylase
E2K99_RS21310	COG1984	allophanate hydrolase subunit 2
E2K99_RS21360	COG1012	belongs to the aldehyde dehydrogenase family
E2K99_RS21360	COG2030	dehydratase
E2K99_RS21365	COG0683	leucine binding
E2K99_RS21380	COG3396	Phenylacetate-CoA oxygenase
E2K99_RS21385	COG3460	Phenylacetate-CoA oxygenase
E2K99_RS21390	COG3396	Phenylacetate-CoA oxygenase
E2K99_RS21395	COG2151	metal-sulfur cluster biosynthetic enzyme
E2K99_RS21400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2K99_RS21405	COG1024	Enoyl-CoA hydratase
E2K99_RS21410	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2K99_RS21415	COG2050	protein possibly involved in aromatic compounds catabolism
E2K99_RS21425	COG0183	Belongs to the thiolase family
E2K99_RS21445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E2K99_RS21450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E2K99_RS21455	COG0742	ribosomal rna small subunit methyltransferase
E2K99_RS21460	COG0612	Peptidase, M16
E2K99_RS21470	COG0612	Peptidase, M16
E2K99_RS21480	COG2884	Cell division ATP-binding protein ftsE
E2K99_RS21490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E2K99_RS21495	COG1999	signal sequence binding
E2K99_RS21500	COG0109	protoheme IX farnesyltransferase activity
E2K99_RS21505	COG1612	heme a metabolic process
E2K99_RS21535	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E2K99_RS21555	COG2226	methyltransferase
E2K99_RS21560	COG1040	competence protein
E2K99_RS21580	COG2984	ABC transporter substrate binding protein
E2K99_RS21600	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E2K99_RS21615	COG0683	leucine binding
E2K99_RS21630	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E2K99_RS21675	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E2K99_RS21705	COG2183	response to ionizing radiation
E2K99_RS21710	COG0193	aminoacyl-tRNA hydrolase activity
E2K99_RS21720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2K99_RS21830	COG0579	oxidoreductase
E2K99_RS21835	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E2K99_RS21840	COG3622	Belongs to the hyi family
E2K99_RS21845	COG2271	Major facilitator Superfamily
E2K99_RS21850	COG0235	Class ii aldolase
E2K99_RS21855	COG3395	kinase activity
E2K99_RS21860	COG2084	Dehydrogenase
E2K99_RS21865	COG2186	Transcriptional regulator
E2K99_RS21880	COG2807	transmembrane transport
E2K99_RS21885	COG2207	Transcriptional regulator
E2K99_RS21890	COG3025	triphosphatase activity
E2K99_RS21900	COG0438	transferase activity, transferring glycosyl groups
E2K99_RS21935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2K99_RS21945	COG0765	amino acid transport
E2K99_RS21950	COG1126	abc transporter atp-binding protein
E2K99_RS21960	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E2K99_RS21970	COG1609	Transcriptional regulator
E2K99_RS21975	COG1953	Uracil, thiamine, allantoin
E2K99_RS22010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2K99_RS22015	COG3845	ABC transporter
E2K99_RS22020	COG4603	Belongs to the binding-protein-dependent transport system permease family
E2K99_RS22025	COG1079	Belongs to the binding-protein-dependent transport system permease family
E2K99_RS22035	COG0850	regulation of cytokinetic process
E2K99_RS22045	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E2K99_RS22050	COG0745	RESPONSE REGULATOR receiver
E2K99_RS22055	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E2K99_RS22060	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E2K99_RS22065	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E2K99_RS22070	COG2890	protein-(glutamine-N5) methyltransferase activity
E2K99_RS22080	COG1858	cytochrome C peroxidase
E2K99_RS22085	COG3186	Phenylalanine-4-hydroxylase
E2K99_RS22095	COG0617	tRNA 3'-terminal CCA addition
E2K99_RS22105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2K99_RS22125	COG1950	PFAM Membrane protein of
E2K99_RS22130	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E2K99_RS22135	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E2K99_RS22145	COG1560	Kdo2-lipid A biosynthetic process
E2K99_RS22150	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E2K99_RS22160	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2K99_RS22170	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E2K99_RS22190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E2K99_RS22200	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E2K99_RS22220	COG2945	thiolester hydrolase activity
E2K99_RS22225	COG1686	Belongs to the peptidase S11 family
E2K99_RS22235	COG0450	alkyl hydroperoxide reductase
E2K99_RS22240	COG0824	Thioesterase
E2K99_RS22245	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E2K99_RS22265	COG0252	asparaginase activity
E2K99_RS22270	COG0583	DNA-binding transcription factor activity
E2K99_RS22285	COG0210	DNA helicase
E2K99_RS22315	COG0765	amino acid transport
E2K99_RS22320	COG0493	'glutamate synthase
E2K99_RS22320	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E2K99_RS22330	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E2K99_RS22335	COG2974	May be involved in recombination
E2K99_RS22340	COG0579	oxidoreductase
E2K99_RS22345	COG1309	transcriptional regulator
E2K99_RS22350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E2K99_RS22365	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E2K99_RS22370	COG0706	membrane insertase activity
E2K99_RS22375	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E2K99_RS22380	COG0594	ribonuclease P activity
E2K99_RS22385	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E2K99_RS22390	COG2766	serine protein kinase
E2K99_RS22395	COG2718	Belongs to the UPF0229 family
E2K99_RS22400	COG2719	SpoVR family
E2K99_RS22415	COG2271	Major facilitator Superfamily
E2K99_RS22455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E2K99_RS22460	COG0300	oxidoreductase activity
E2K99_RS22465	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E2K99_RS22475	COG0018	arginyl-trna synthetase
E2K99_RS22480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E2K99_RS22485	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E2K99_RS22495	COG2326	polyphosphate kinase activity
E2K99_RS22500	COG1832	CoA-binding protein
E2K99_RS22505	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E2K99_RS22510	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E2K99_RS22515	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E2K99_RS22520	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E2K99_RS22525	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E2K99_RS22530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E2K99_RS22540	COG0356	it plays a direct role in the translocation of protons across the membrane
E2K99_RS22550	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E2K99_RS22565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E2K99_RS22590	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E2K99_RS22605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2K99_RS22610	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E2K99_RS22615	COG1088	dTDP-glucose 4,6-dehydratase activity
E2K99_RS22620	COG3959	Transketolase, thiamine diphosphate binding domain
E2K99_RS22625	COG3958	Transketolase
E2K99_RS22640	COG2226	methyltransferase
E2K99_RS22660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E2K99_RS22665	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E2K99_RS22665	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E2K99_RS22700	COG0540	Belongs to the ATCase OTCase family
E2K99_RS22715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E2K99_RS22775	COG1538	Outer membrane efflux protein
E2K99_RS22780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2K99_RS22820	COG2255	four-way junction helicase activity
E2K99_RS22890	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E2K99_RS22905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2K99_RS22910	COG0642	Histidine kinase
E2K99_RS22930	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS22945	COG1448	Aminotransferase
E2K99_RS22960	COG0583	DNA-binding transcription factor activity
E2K99_RS22965	COG0037	tRNA processing
E2K99_RS22980	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E2K99_RS22985	COG1522	sequence-specific DNA binding
E2K99_RS23020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2K99_RS23035	COG1137	ATPase activity
E2K99_RS23050	COG1079	Belongs to the binding-protein-dependent transport system permease family
E2K99_RS23095	COG0840	transmembrane signaling receptor activity
E2K99_RS23100	COG0583	DNA-binding transcription factor activity
E2K99_RS23105	COG0277	FAD linked oxidase domain protein
E2K99_RS23110	COG0247	lactate metabolic process
E2K99_RS23115	COG0277	FAD linked oxidase domain protein
E2K99_RS23125	COG2271	Major facilitator Superfamily
E2K99_RS23130	COG2272	Belongs to the type-B carboxylesterase lipase family
E2K99_RS23135	COG0583	DNA-binding transcription factor activity
E2K99_RS23140	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E2K99_RS23165	COG0183	Belongs to the thiolase family
E2K99_RS23185	COG3842	ATPase activity
E2K99_RS23190	COG1177	transmembrane transport
E2K99_RS23195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2K99_RS23205	COG0251	oxidation-reduction process
E2K99_RS23210	COG3048	D-serine ammonia-lyase activity
E2K99_RS23220	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E2K99_RS23240	COG0738	Major facilitator superfamily
E2K99_RS23245	COG0028	Belongs to the TPP enzyme family
E2K99_RS23255	COG1609	Transcriptional regulator
E2K99_RS23260	COG1346	cytolysis
E2K99_RS23265	COG1380	Effector of murein hydrolase LrgA
E2K99_RS23275	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS23285	COG2267	carboxylic ester hydrolase activity
E2K99_RS23295	COG1027	Aspartate ammonia-lyase
E2K99_RS23300	COG1609	Transcriptional regulator
E2K99_RS23305	COG1012	belongs to the aldehyde dehydrogenase family
E2K99_RS23320	COG2409	Drug exporters of the RND superfamily
E2K99_RS23335	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E2K99_RS23340	COG3938	Belongs to the proline racemase family
E2K99_RS23345	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E2K99_RS23350	COG1349	DNA-binding transcription factor activity
E2K99_RS23355	COG2223	nitrite transmembrane transporter activity
E2K99_RS23375	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E2K99_RS23390	COG2318	DinB family
E2K99_RS23420	COG0604	alcohol dehydrogenase
E2K99_RS23420	COG3321	synthase
E2K99_RS23445	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E2K99_RS23450	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2K99_RS23475	COG0583	DNA-binding transcription factor activity
E2K99_RS23490	COG2205	protein histidine kinase activity
E2K99_RS23515	COG3707	response regulator
E2K99_RS23525	COG4770	biotin carboxylase activity
E2K99_RS23540	COG3842	ATPase activity
E2K99_RS23620	COG1064	alcohol dehydrogenase
E2K99_RS23625	COG3608	succinylglutamate desuccinylase aspartoacylase
E2K99_RS23625	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E2K99_RS23660	COG2207	Transcriptional regulator
E2K99_RS23660	COG1609	Transcriptional regulator
E2K99_RS23665	COG4213	ABC transporter substrate-binding protein
E2K99_RS23670	COG1129	ABC transporter
E2K99_RS23675	COG4214	carbohydrate transport
E2K99_RS23685	COG0129	dihydroxy-acid dehydratase activity
E2K99_RS23695	COG5001	Diguanylate cyclase
E2K99_RS23695	COG3706	GGDEF domain
E2K99_RS23695	COG2203	Gaf domain
E2K99_RS23695	COG4251	negative regulation of phosphorylation
E2K99_RS23700	COG1686	Belongs to the peptidase S11 family
E2K99_RS23725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E2K99_RS23740	COG4566	intracellular signal transduction
E2K99_RS23760	COG0783	Belongs to the Dps family
E2K99_RS23775	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E2K99_RS23780	COG1335	isochorismatase
E2K99_RS23800	COG4191	Histidine kinase
E2K99_RS23805	COG2207	Transcriptional regulator
E2K99_RS23825	COG0583	DNA-binding transcription factor activity
E2K99_RS23830	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2K99_RS23840	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2K99_RS23845	COG3842	ATPase activity
E2K99_RS23855	COG1840	ABC-type Fe3 transport system, periplasmic component
E2K99_RS23875	COG0840	transmembrane signaling receptor activity
E2K99_RS23885	COG2986	histidine ammonia-lyase
E2K99_RS23895	COG1301	dicarboxylic acid transport
E2K99_RS23905	COG0840	transmembrane signaling receptor activity
E2K99_RS23920	COG0667	Aldo Keto reductase
E2K99_RS23935	COG1653	transport
E2K99_RS23945	COG1175	transmembrane transport
E2K99_RS23950	COG0395	ABC-type sugar transport system, permease component
E2K99_RS23955	COG3842	ATPase activity
E2K99_RS23960	COG2971	BadF BadG BcrA BcrD
E2K99_RS23970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E2K99_RS23975	COG0583	DNA-binding transcription factor activity
E2K99_RS23985	COG3064	Membrane
E2K99_RS24005	COG2010	Cytochrome c
E2K99_RS24015	COG0640	Transcriptional regulator
E2K99_RS24050	COG0625	glutathione transferase activity
E2K99_RS24065	COG0583	DNA-binding transcription factor activity
E2K99_RS24080	COG1056	cytidyltransferase-related domain
E2K99_RS24080	COG1051	belongs to the nudix hydrolase family
E2K99_RS24085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E2K99_RS24085	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E2K99_RS24090	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E2K99_RS24165	COG0477	Major facilitator Superfamily
E2K99_RS24170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E2K99_RS24180	COG1335	isochorismatase
E2K99_RS24185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2K99_RS24190	COG2194	sulfuric ester hydrolase activity
E2K99_RS24200	COG3618	amidohydrolase
E2K99_RS24205	COG2814	Major facilitator Superfamily
E2K99_RS24230	COG0625	glutathione transferase activity
E2K99_RS24235	COG2271	Major facilitator Superfamily
E2K99_RS24240	COG2186	Transcriptional regulator
E2K99_RS24245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2K99_RS24255	COG0765	amino acid transport
E2K99_RS24260	COG0765	amino acid transport
E2K99_RS24265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2K99_RS24280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2K99_RS24290	COG2205	protein histidine kinase activity
E2K99_RS24295	COG0745	RESPONSE REGULATOR receiver
E2K99_RS24300	COG0840	transmembrane signaling receptor activity
E2K99_RS24375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E2K99_RS24390	COG4221	oxidoreductase activity
E2K99_RS24395	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
E2K99_RS24400	COG2814	Major facilitator Superfamily
E2K99_RS24415	COG5001	Diguanylate cyclase
E2K99_RS24415	COG4251	negative regulation of phosphorylation
E2K99_RS24415	COG2203	Gaf domain
E2K99_RS24415	COG3706	GGDEF domain
E2K99_RS24430	COG4566	intracellular signal transduction
E2K99_RS24435	COG0583	DNA-binding transcription factor activity
E2K99_RS24445	COG2910	NAD(P)H-binding
E2K99_RS24485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2K99_RS24490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E2K99_RS24505	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2K99_RS24510	COG4177	L-phenylalanine transmembrane transporter activity
E2K99_RS24535	COG0840	transmembrane signaling receptor activity
E2K99_RS24540	COG2175	clavaminate synthase activity
E2K99_RS24550	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E2K99_RS24555	COG0154	amidase activity
E2K99_RS24560	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E2K99_RS24565	COG1077	Cell shape determining protein MreB Mrl
E2K99_RS24570	COG1792	Involved in formation and maintenance of cell shape
E2K99_RS24580	COG0768	penicillin binding
E2K99_RS24585	COG0772	Belongs to the SEDS family
E2K99_RS24590	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E2K99_RS24595	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E2K99_RS24600	COG3107	peptidoglycan biosynthetic process
E2K99_RS24605	COG0792	nuclease activity
E2K99_RS24610	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E2K99_RS24615	COG2823	Periplasmic or secreted lipoprotein
E2K99_RS24630	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E2K99_RS24635	COG0708	Exodeoxyribonuclease III
E2K99_RS24640	COG0551	DNA topoisomerase type I activity
E2K99_RS24640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E2K99_RS24645	COG2922	Belongs to the Smg family
E2K99_RS24650	COG0758	DNA mediated transformation
E2K99_RS24655	COG0242	peptide deformylase activity
E2K99_RS24670	COG1960	acyl-CoA dehydrogenase activity
E2K99_RS24680	COG3012	SEC-C Motif Domain Protein
E2K99_RS24685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E2K99_RS24740	COG3210	domain, Protein
E2K99_RS24745	COG2831	hemolysin activation secretion protein
E2K99_RS24750	COG2070	2-Nitropropane dioxygenase
E2K99_RS24760	COG0596	Alpha beta hydrolase
E2K99_RS24765	COG2223	nitrite transmembrane transporter activity
E2K99_RS24780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E2K99_RS24795	COG0318	PFAM AMP-dependent synthetase and ligase
E2K99_RS24815	COG0488	(ABC) transporter
E2K99_RS24825	COG2814	Major facilitator Superfamily
E2K99_RS24830	COG1653	transport
E2K99_RS24835	COG2203	Gaf domain
E2K99_RS24835	COG5001	Diguanylate cyclase
E2K99_RS24835	COG4251	negative regulation of phosphorylation
E2K99_RS24835	COG3706	GGDEF domain
E2K99_RS24860	COG0411	ABC transporter
E2K99_RS24870	COG0829	nickel cation binding
E2K99_RS24875	COG0831	urea catabolic process
E2K99_RS24880	COG0832	Belongs to the urease beta subunit family
E2K99_RS24885	COG0804	urea catabolic process
E2K99_RS24890	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
E2K99_RS24895	COG0830	nickel cation binding
E2K99_RS24900	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E2K99_RS24915	COG3639	organic phosphonate transmembrane transporter activity
E2K99_RS24920	COG3639	organic phosphonate transmembrane transporter activity
E2K99_RS24995	COG2823	Periplasmic or secreted lipoprotein
E2K99_RS25000	COG2204	response regulator
E2K99_RS25010	COG2205	protein histidine kinase activity
E2K99_RS25015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2K99_RS25020	COG2814	Major facilitator Superfamily
E2K99_RS25035	COG0302	gtp cyclohydrolase
E2K99_RS25060	COG1028	Short-chain dehydrogenase reductase Sdr
E2K99_RS25065	COG0765	amino acid transport
E2K99_RS25070	COG1126	abc transporter atp-binding protein
E2K99_RS25120	COG0697	spore germination
E2K99_RS25155	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
E2K99_RS25170	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E2K99_RS25170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2K99_RS25185	COG0523	cobalamin synthesis protein
E2K99_RS25190	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E2K99_RS25205	COG3177	Filamentation induced by cAMP protein fic
E2K99_RS25210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E2K99_RS25215	COG0321	lipoyl(octanoyl) transferase activity
E2K99_RS25225	COG0583	DNA-binding transcription factor activity
E2K99_RS25230	COG2921	Belongs to the UPF0250 family
E2K99_RS25245	COG4178	(ABC) transporter
E2K99_RS25250	COG0840	transmembrane signaling receptor activity
E2K99_RS25255	COG1418	mRNA catabolic process
E2K99_RS25260	COG1132	(ABC) transporter
E2K99_RS25280	COG1192	Involved in chromosome partitioning
E2K99_RS25290	COG3040	lipid binding
E2K99_RS25295	COG0357	Ribosomal RNA small subunit methyltransferase G
E2K99_RS25300	COG0445	tRNA wobble uridine modification
E2K99_RS25310	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2K99_RS25330	COG0411	ABC transporter
E2K99_RS25355	COG2982	Protein involved in outer membrane biogenesis
E2K99_RS25375	COG0121	glutamine amidotransferase