locus-tag	class	description
hmeg3_RS00010	COG0583	DNA-binding transcription factor activity
hmeg3_RS00020	COG1012	belongs to the aldehyde dehydrogenase family
hmeg3_RS00055	COG1126	abc transporter atp-binding protein
hmeg3_RS00060	COG0765	amino acid transport
hmeg3_RS00065	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS00070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
hmeg3_RS00085	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
hmeg3_RS00090	COG1116	anion transmembrane transporter activity
hmeg3_RS00095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
hmeg3_RS00100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
hmeg3_RS00105	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS00120	COG1414	Transcriptional regulator
hmeg3_RS00125	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS00130	COG0028	Belongs to the TPP enzyme family
hmeg3_RS00135	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
hmeg3_RS00140	COG1012	belongs to the aldehyde dehydrogenase family
hmeg3_RS00190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
hmeg3_RS00205	COG0302	gtp cyclohydrolase
hmeg3_RS00220	COG2814	Major facilitator Superfamily
hmeg3_RS00225	COG2205	protein histidine kinase activity
hmeg3_RS00235	COG2204	response regulator
hmeg3_RS00275	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
hmeg3_RS00280	COG0830	nickel cation binding
hmeg3_RS00285	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
hmeg3_RS00290	COG0804	urea catabolic process
hmeg3_RS00295	COG0832	Belongs to the urease beta subunit family
hmeg3_RS00300	COG0831	urea catabolic process
hmeg3_RS00305	COG0829	nickel cation binding
hmeg3_RS00315	COG0411	ABC transporter
hmeg3_RS00340	COG1418	mRNA catabolic process
hmeg3_RS00345	COG1278	Cold shock
hmeg3_RS00355	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
hmeg3_RS00375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
hmeg3_RS00385	COG2824	Alkylphosphonate utilization operon protein PhnA
hmeg3_RS00390	COG0673	inositol 2-dehydrogenase activity
hmeg3_RS00400	COG0840	transmembrane signaling receptor activity
hmeg3_RS00410	COG4251	negative regulation of phosphorylation
hmeg3_RS00410	COG2203	Gaf domain
hmeg3_RS00410	COG3706	GGDEF domain
hmeg3_RS00410	COG5001	Diguanylate cyclase
hmeg3_RS00420	COG2814	Major facilitator Superfamily
hmeg3_RS00425	COG2188	Transcriptional regulator
hmeg3_RS00430	COG0747	negative chemotaxis
hmeg3_RS00440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
hmeg3_RS00445	COG4608	Belongs to the ABC transporter superfamily
hmeg3_RS00450	COG0444	Belongs to the ABC transporter superfamily
hmeg3_RS00455	COG0154	amidase activity
hmeg3_RS00470	COG0488	(ABC) transporter
hmeg3_RS00500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
hmeg3_RS00505	COG1017	nitric oxide dioxygenase activity
hmeg3_RS00505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
hmeg3_RS00510	COG0625	glutathione transferase activity
hmeg3_RS00515	COG0583	DNA-binding transcription factor activity
hmeg3_RS00525	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
hmeg3_RS00530	COG2223	nitrite transmembrane transporter activity
hmeg3_RS00550	COG2070	2-Nitropropane dioxygenase
hmeg3_RS00555	COG0840	transmembrane signaling receptor activity
hmeg3_RS00570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
hmeg3_RS00575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
hmeg3_RS00580	COG4770	biotin carboxylase activity
hmeg3_RS00590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
hmeg3_RS00595	COG3012	SEC-C Motif Domain Protein
hmeg3_RS00610	COG1960	acyl-CoA dehydrogenase activity
hmeg3_RS00615	COG0789	Transcriptional regulator
hmeg3_RS00625	COG0242	peptide deformylase activity
hmeg3_RS00635	COG0758	DNA mediated transformation
hmeg3_RS00640	COG2922	Belongs to the Smg family
hmeg3_RS00645	COG0551	DNA topoisomerase type I activity
hmeg3_RS00645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
hmeg3_RS00650	COG0708	Exodeoxyribonuclease III
hmeg3_RS00655	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
hmeg3_RS00665	COG2175	clavaminate synthase activity
hmeg3_RS00670	COG1309	transcriptional regulator
hmeg3_RS00680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
hmeg3_RS00700	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
hmeg3_RS00705	COG0154	amidase activity
hmeg3_RS00710	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
hmeg3_RS00715	COG1077	Cell shape determining protein MreB Mrl
hmeg3_RS00730	COG0768	penicillin binding
hmeg3_RS00735	COG0772	Belongs to the SEDS family
hmeg3_RS00750	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
hmeg3_RS00755	COG3107	peptidoglycan biosynthetic process
hmeg3_RS00760	COG0792	nuclease activity
hmeg3_RS00765	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
hmeg3_RS00780	COG0840	transmembrane signaling receptor activity
hmeg3_RS00790	COG0697	spore germination
hmeg3_RS00820	COG0559	Belongs to the binding-protein-dependent transport system permease family
hmeg3_RS00835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
hmeg3_RS00840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
hmeg3_RS00860	COG0583	DNA-binding transcription factor activity
hmeg3_RS00865	COG4566	intracellular signal transduction
hmeg3_RS00895	COG0625	glutathione transferase activity
hmeg3_RS00905	COG4221	oxidoreductase activity
hmeg3_RS00915	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
hmeg3_RS00950	COG1538	Outer membrane efflux protein
hmeg3_RS00955	COG2814	Major facilitator Superfamily
hmeg3_RS00960	COG1566	PFAM secretion protein HlyD family protein
hmeg3_RS00975	COG0840	transmembrane signaling receptor activity
hmeg3_RS00990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
hmeg3_RS01005	COG0840	transmembrane signaling receptor activity
hmeg3_RS01075	COG1846	Transcriptional regulator
hmeg3_RS01080	COG1960	acyl-CoA dehydrogenase activity
hmeg3_RS01120	COG0183	Belongs to the thiolase family
hmeg3_RS01125	COG1022	Amp-dependent synthetase and ligase
hmeg3_RS01130	COG1024	Enoyl-CoA hydratase
hmeg3_RS01135	COG0683	leucine binding
hmeg3_RS01145	COG1414	Transcriptional regulator
hmeg3_RS01155	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
hmeg3_RS01160	COG0183	Belongs to the thiolase family
hmeg3_RS01175	COG0411	ABC transporter
hmeg3_RS01185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
hmeg3_RS01195	COG0683	leucine binding
hmeg3_RS01225	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
hmeg3_RS01230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
hmeg3_RS01240	COG3485	protocatechuate 3,4-dioxygenase
hmeg3_RS01245	COG1414	Transcriptional regulator
hmeg3_RS01265	COG0840	transmembrane signaling receptor activity
hmeg3_RS01285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
hmeg3_RS01305	COG4638	Rieske (2fe-2S)
hmeg3_RS01310	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
hmeg3_RS01315	COG0543	2 iron, 2 sulfur cluster binding
hmeg3_RS01315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
hmeg3_RS01360	COG3706	GGDEF domain
hmeg3_RS01385	COG0840	transmembrane signaling receptor activity
hmeg3_RS01395	COG2175	clavaminate synthase activity
hmeg3_RS01430	COG0583	DNA-binding transcription factor activity
hmeg3_RS01450	COG0745	RESPONSE REGULATOR receiver
hmeg3_RS01455	COG5002	protein histidine kinase activity
hmeg3_RS01455	COG2198	Histidine kinase
hmeg3_RS01455	COG0784	Response regulator, receiver
hmeg3_RS01485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
hmeg3_RS01500	COG2207	Transcriptional regulator
hmeg3_RS01505	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS01515	COG1733	regulation of RNA biosynthetic process
hmeg3_RS01520	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
hmeg3_RS01525	COG4772	TonB-dependent receptor
hmeg3_RS01530	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS01540	COG0076	glutamate decarboxylase activity
hmeg3_RS01555	COG0477	Major facilitator Superfamily
hmeg3_RS01560	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
hmeg3_RS01565	COG0697	spore germination
hmeg3_RS01590	COG2814	Major facilitator Superfamily
hmeg3_RS01600	COG0456	acetyltransferase
hmeg3_RS01605	COG0840	transmembrane signaling receptor activity
hmeg3_RS01620	COG2197	response regulator
hmeg3_RS01630	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
hmeg3_RS01640	COG3706	GGDEF domain
hmeg3_RS01660	COG0129	dihydroxy-acid dehydratase activity
hmeg3_RS01675	COG0477	Major facilitator Superfamily
hmeg3_RS01680	COG3706	GGDEF domain
hmeg3_RS01705	COG0840	transmembrane signaling receptor activity
hmeg3_RS01730	COG4191	Histidine kinase
hmeg3_RS01735	COG0702	epimerase
hmeg3_RS01740	COG0604	alcohol dehydrogenase
hmeg3_RS01740	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS01740	COG3321	synthase
hmeg3_RS01745	COG0583	DNA-binding transcription factor activity
hmeg3_RS01750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
hmeg3_RS01760	COG1278	Cold shock
hmeg3_RS01805	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
hmeg3_RS01815	COG0765	amino acid transport
hmeg3_RS01820	COG0765	amino acid transport
hmeg3_RS01825	COG1126	abc transporter atp-binding protein
hmeg3_RS01835	COG4251	negative regulation of phosphorylation
hmeg3_RS01835	COG5001	Diguanylate cyclase
hmeg3_RS01835	COG2203	Gaf domain
hmeg3_RS01835	COG3706	GGDEF domain
hmeg3_RS01845	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS01870	COG0583	DNA-binding transcription factor activity
hmeg3_RS01875	COG0840	transmembrane signaling receptor activity
hmeg3_RS01895	COG1522	sequence-specific DNA binding
hmeg3_RS01900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
hmeg3_RS01905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
hmeg3_RS01920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
hmeg3_RS01930	COG1216	Glycosyl transferase, family 2
hmeg3_RS01985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
hmeg3_RS01995	COG0037	tRNA processing
hmeg3_RS02025	COG0642	Histidine kinase
hmeg3_RS02030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
hmeg3_RS02040	COG2249	NAD(P)H dehydrogenase (quinone) activity
hmeg3_RS02045	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
hmeg3_RS02110	COG5002	protein histidine kinase activity
hmeg3_RS02115	COG0745	RESPONSE REGULATOR receiver
hmeg3_RS02130	COG2372	response to copper ion
hmeg3_RS02140	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
hmeg3_RS02145	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
hmeg3_RS02150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
hmeg3_RS02220	COG5002	protein histidine kinase activity
hmeg3_RS02225	COG0745	RESPONSE REGULATOR receiver
hmeg3_RS02230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
hmeg3_RS02275	COG0243	molybdopterin cofactor binding
hmeg3_RS02280	COG0723	plastoquinol--plastocyanin reductase activity
hmeg3_RS02285	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
hmeg3_RS02295	COG4191	Histidine kinase
hmeg3_RS02295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
hmeg3_RS02325	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
hmeg3_RS02330	COG0640	Transcriptional regulator
hmeg3_RS02335	COG2072	flavoprotein involved in K transport
hmeg3_RS02345	COG0431	NADPH-dependent FMN reductase
hmeg3_RS02360	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
hmeg3_RS02365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
hmeg3_RS02415	COG0356	it plays a direct role in the translocation of protons across the membrane
hmeg3_RS02425	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
hmeg3_RS02430	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
hmeg3_RS02435	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
hmeg3_RS02440	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
hmeg3_RS02445	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
hmeg3_RS02450	COG0355	proton-transporting ATP synthase activity, rotational mechanism
hmeg3_RS02460	COG1832	CoA-binding protein
hmeg3_RS02465	COG2326	polyphosphate kinase activity
hmeg3_RS02480	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
hmeg3_RS02485	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
hmeg3_RS02495	COG0018	arginyl-trna synthetase
hmeg3_RS02505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
hmeg3_RS02510	COG0300	oxidoreductase activity
hmeg3_RS02515	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
hmeg3_RS02520	COG0583	DNA-binding transcription factor activity
hmeg3_RS02530	COG1335	isochorismatase
hmeg3_RS02535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
hmeg3_RS02550	COG2271	Major facilitator Superfamily
hmeg3_RS02560	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
hmeg3_RS02565	COG2719	SpoVR family
hmeg3_RS02570	COG2718	Belongs to the UPF0229 family
hmeg3_RS02575	COG2766	serine protein kinase
hmeg3_RS02580	COG0230	Belongs to the bacterial ribosomal protein bL34 family
hmeg3_RS02585	COG0594	ribonuclease P activity
hmeg3_RS02590	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
hmeg3_RS02595	COG0706	membrane insertase activity
hmeg3_RS02600	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
hmeg3_RS02620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
hmeg3_RS02625	COG1309	transcriptional regulator
hmeg3_RS02630	COG2974	May be involved in recombination
hmeg3_RS02635	COG3121	Chaperone
hmeg3_RS02640	COG3539	Fimbrial protein
hmeg3_RS02645	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
hmeg3_RS02650	COG2900	Belongs to the SlyX family
hmeg3_RS02660	COG0765	amino acid transport
hmeg3_RS02675	COG0210	DNA helicase
hmeg3_RS02690	COG0583	DNA-binding transcription factor activity
hmeg3_RS02720	COG3842	ATPase activity
hmeg3_RS02725	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
hmeg3_RS02730	COG0252	asparaginase activity
hmeg3_RS02750	COG0604	alcohol dehydrogenase
hmeg3_RS02750	COG3321	synthase
hmeg3_RS02760	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
hmeg3_RS02775	COG3634	alkyl hydroperoxide reductase activity
hmeg3_RS02780	COG1686	Belongs to the peptidase S11 family
hmeg3_RS02785	COG2945	thiolester hydrolase activity
hmeg3_RS02800	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
hmeg3_RS02800	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
hmeg3_RS02810	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
hmeg3_RS02820	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
hmeg3_RS02840	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
hmeg3_RS02850	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
hmeg3_RS02860	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
hmeg3_RS02865	COG1560	Kdo2-lipid A biosynthetic process
hmeg3_RS02875	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
hmeg3_RS02880	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
hmeg3_RS02885	COG1950	PFAM Membrane protein of
hmeg3_RS02915	COG0617	tRNA 3'-terminal CCA addition
hmeg3_RS02925	COG3186	Phenylalanine-4-hydroxylase
hmeg3_RS02935	COG2890	protein-(glutamine-N5) methyltransferase activity
hmeg3_RS02940	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
hmeg3_RS02945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
hmeg3_RS02950	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
hmeg3_RS02965	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
hmeg3_RS02975	COG0850	regulation of cytokinetic process
hmeg3_RS02995	COG4603	Belongs to the binding-protein-dependent transport system permease family
hmeg3_RS03000	COG3845	ABC transporter
hmeg3_RS03005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
hmeg3_RS03045	COG1953	Uracil, thiamine, allantoin
hmeg3_RS03060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
hmeg3_RS03065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
hmeg3_RS03080	COG0765	amino acid transport
hmeg3_RS03085	COG0765	amino acid transport
hmeg3_RS03095	COG2186	Transcriptional regulator
hmeg3_RS03105	COG2186	Transcriptional regulator
hmeg3_RS03110	COG2084	Dehydrogenase
hmeg3_RS03115	COG3395	kinase activity
hmeg3_RS03120	COG0235	Class ii aldolase
hmeg3_RS03125	COG2271	Major facilitator Superfamily
hmeg3_RS03130	COG3622	Belongs to the hyi family
hmeg3_RS03140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
hmeg3_RS03150	COG0193	aminoacyl-tRNA hydrolase activity
hmeg3_RS03155	COG2183	response to ionizing radiation
hmeg3_RS03170	COG0232	Belongs to the dGTPase family. Type 2 subfamily
hmeg3_RS03175	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
hmeg3_RS03210	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
hmeg3_RS03235	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
hmeg3_RS03250	COG2984	ABC transporter substrate binding protein
hmeg3_RS03260	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
hmeg3_RS03270	COG1040	competence protein
hmeg3_RS03275	COG2226	methyltransferase
hmeg3_RS03295	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
hmeg3_RS03325	COG1612	heme a metabolic process
hmeg3_RS03330	COG0109	protoheme IX farnesyltransferase activity
hmeg3_RS03335	COG1999	signal sequence binding
hmeg3_RS03340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
hmeg3_RS03345	COG2177	Part of the ABC transporter FtsEX involved in
hmeg3_RS03350	COG2884	Cell division ATP-binding protein ftsE
hmeg3_RS03360	COG0612	Peptidase, M16
hmeg3_RS03370	COG0612	Peptidase, M16
hmeg3_RS03375	COG0742	ribosomal rna small subunit methyltransferase
hmeg3_RS03380	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
hmeg3_RS03385	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
hmeg3_RS03415	COG2814	Major facilitator Superfamily
hmeg3_RS03420	COG0012	GTP binding
hmeg3_RS03425	COG1127	ABC transporter
hmeg3_RS03430	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
hmeg3_RS03435	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
hmeg3_RS03440	COG2853	Lipoprotein
hmeg3_RS03455	COG1131	(ABC) transporter
hmeg3_RS03460	COG0842	Transport permease protein
hmeg3_RS03465	COG0271	Belongs to the BolA IbaG family
hmeg3_RS03470	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
hmeg3_RS03475	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
hmeg3_RS03480	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
hmeg3_RS03490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
hmeg3_RS03495	COG0131	Imidazoleglycerol-phosphate dehydratase
hmeg3_RS03500	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
hmeg3_RS03505	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
hmeg3_RS03510	COG0107	imidazoleglycerol-phosphate synthase activity
hmeg3_RS03515	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
hmeg3_RS03520	COG0140	phosphoribosyl-ATP diphosphatase activity
hmeg3_RS03530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
hmeg3_RS03535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
hmeg3_RS03540	COG0805	protein transport
hmeg3_RS03550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
hmeg3_RS03555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
hmeg3_RS03560	COG1970	mechanosensitive ion channel activity
hmeg3_RS03565	COG0723	plastoquinol--plastocyanin reductase activity
hmeg3_RS03570	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
hmeg3_RS03575	COG2857	Cytochrome c1
hmeg3_RS03580	COG0625	glutathione transferase activity
hmeg3_RS03585	COG2969	positive regulation of protein catabolic process
hmeg3_RS03610	COG4191	Histidine kinase
hmeg3_RS03635	COG5002	protein histidine kinase activity
hmeg3_RS03640	COG4251	negative regulation of phosphorylation
hmeg3_RS03645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
hmeg3_RS03670	COG2144	transferase activity, transferring acyl groups
hmeg3_RS03675	COG0438	transferase activity, transferring glycosyl groups
hmeg3_RS03695	COG0583	DNA-binding transcription factor activity
hmeg3_RS03700	COG2271	Major facilitator Superfamily
hmeg3_RS03705	COG0154	amidase activity
hmeg3_RS03715	COG0840	transmembrane signaling receptor activity
hmeg3_RS03720	COG1522	sequence-specific DNA binding
hmeg3_RS03730	COG0454	-acetyltransferase
hmeg3_RS03735	COG1012	belongs to the aldehyde dehydrogenase family
hmeg3_RS03740	COG0473	3-isopropylmalate dehydrogenase activity
hmeg3_RS03745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
hmeg3_RS03750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
hmeg3_RS03770	COG0601	transmembrane transport
hmeg3_RS03775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
hmeg3_RS03790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
hmeg3_RS03800	COG1473	amidohydrolase
hmeg3_RS03805	COG1522	sequence-specific DNA binding
hmeg3_RS03810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
hmeg3_RS03825	COG3121	Chaperone
hmeg3_RS03845	COG2515	1-aminocyclopropane-1-carboxylate deaminase
hmeg3_RS03850	COG1522	sequence-specific DNA binding
hmeg3_RS03860	COG0747	negative chemotaxis
hmeg3_RS03875	COG0444	Belongs to the ABC transporter superfamily
hmeg3_RS03880	COG4608	Belongs to the ABC transporter superfamily
hmeg3_RS03885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
hmeg3_RS03890	COG1473	amidohydrolase
hmeg3_RS03900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
hmeg3_RS03905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
hmeg3_RS03910	COG1309	transcriptional regulator
hmeg3_RS03920	COG3474	cytochrome
hmeg3_RS03945	COG0747	negative chemotaxis
hmeg3_RS03950	COG4172	Belongs to the ABC transporter superfamily
hmeg3_RS03970	COG0583	DNA-binding transcription factor activity
hmeg3_RS03980	COG5001	Diguanylate cyclase
hmeg3_RS03980	COG4251	negative regulation of phosphorylation
hmeg3_RS03980	COG2203	Gaf domain
hmeg3_RS03980	COG3706	GGDEF domain
hmeg3_RS03990	COG0840	transmembrane signaling receptor activity
hmeg3_RS03995	COG1522	sequence-specific DNA binding
hmeg3_RS04005	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS04010	COG0163	prenyltransferase activity
hmeg3_RS04015	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
hmeg3_RS04020	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
hmeg3_RS04025	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
hmeg3_RS04030	COG1137	ATPase activity
hmeg3_RS04035	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
hmeg3_RS04045	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
hmeg3_RS04050	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
hmeg3_RS04050	COG0517	IMP dehydrogenase activity
hmeg3_RS04065	COG0840	transmembrane signaling receptor activity
hmeg3_RS04085	COG2814	Major facilitator Superfamily
hmeg3_RS04090	COG0629	single-stranded DNA binding
hmeg3_RS04110	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS04115	COG0583	DNA-binding transcription factor activity
hmeg3_RS04120	COG0625	glutathione transferase activity
hmeg3_RS04135	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
hmeg3_RS04140	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
hmeg3_RS04185	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
hmeg3_RS04205	COG0300	oxidoreductase activity
hmeg3_RS04225	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
hmeg3_RS04230	COG2119	membrane
hmeg3_RS04235	COG0252	asparaginase activity
hmeg3_RS04240	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
hmeg3_RS04250	COG0477	Major facilitator Superfamily
hmeg3_RS04260	COG0583	DNA-binding transcription factor activity
hmeg3_RS04270	COG0861	Integral membrane protein TerC family
hmeg3_RS04280	COG0067	glutamate synthase
hmeg3_RS04280	COG0069	glutamate synthase activity
hmeg3_RS04280	COG0070	glutamate synthase
hmeg3_RS04295	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
hmeg3_RS04300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
hmeg3_RS04310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
hmeg3_RS04315	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
hmeg3_RS04325	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
hmeg3_RS04330	COG1194	a g-specific adenine glycosylase
hmeg3_RS04335	COG1660	Displays ATPase and GTPase activities
hmeg3_RS04340	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
hmeg3_RS04355	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
hmeg3_RS04355	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
hmeg3_RS04360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
hmeg3_RS04365	COG1238	metal cluster binding
hmeg3_RS04390	COG1247	-acetyltransferase
hmeg3_RS04395	COG2226	methyltransferase
hmeg3_RS04410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
hmeg3_RS04415	COG0477	Major facilitator Superfamily
hmeg3_RS04425	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS04430	COG0134	indole-3-glycerol-phosphate synthase activity
hmeg3_RS04435	COG1280	lysine exporter protein (LysE YggA)
hmeg3_RS04440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
hmeg3_RS04445	COG0512	Glutamine amidotransferase of anthranilate synthase
hmeg3_RS04455	COG0546	phosphoglycolate phosphatase activity
hmeg3_RS04460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
hmeg3_RS04465	COG2967	ApaG domain
hmeg3_RS04470	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
hmeg3_RS04480	COG1024	Enoyl-CoA hydratase
hmeg3_RS04510	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
hmeg3_RS04520	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS04530	COG2721	sulfolactate sulfo-lyase activity
hmeg3_RS04545	COG0765	amino acid transport
hmeg3_RS04550	COG0765	amino acid transport
hmeg3_RS04580	COG1473	amidohydrolase
hmeg3_RS04585	COG0601	transmembrane transport
hmeg3_RS04595	COG0444	Belongs to the ABC transporter superfamily
hmeg3_RS04600	COG4608	Belongs to the ABC transporter superfamily
hmeg3_RS04620	COG0243	molybdopterin cofactor binding
hmeg3_RS04630	COG0318	PFAM AMP-dependent synthetase and ligase
hmeg3_RS04635	COG0800	Aldolase
hmeg3_RS04640	COG3734	2-keto-3-deoxy-galactonokinase
hmeg3_RS04645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
hmeg3_RS04650	COG1607	acyl-coa hydrolase
hmeg3_RS04655	COG5265	(ABC) transporter
hmeg3_RS04665	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
hmeg3_RS04670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
hmeg3_RS04680	COG0765	amino acid transport
hmeg3_RS04685	COG0765	amino acid transport
hmeg3_RS04690	COG1126	abc transporter atp-binding protein
hmeg3_RS04695	COG0418	dihydroorotase activity
hmeg3_RS04710	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
hmeg3_RS04715	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
hmeg3_RS04720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
hmeg3_RS04735	COG0316	Belongs to the HesB IscA family
hmeg3_RS04740	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
hmeg3_RS04745	COG0351	phosphomethylpyrimidine kinase
hmeg3_RS04750	COG1773	rubredoxin
hmeg3_RS04770	COG0840	transmembrane signaling receptor activity
hmeg3_RS04775	COG0784	Response regulator, receiver
hmeg3_RS04775	COG0643	Histidine kinase
hmeg3_RS04775	COG2198	Histidine kinase
hmeg3_RS04775	COG0784	Response regulator, receiver
hmeg3_RS04775	COG2198	Histidine kinase
hmeg3_RS04775	COG0643	Histidine kinase
hmeg3_RS04805	COG1722	exodeoxyribonuclease VII activity
hmeg3_RS04810	COG0142	geranyltranstransferase activity
hmeg3_RS04820	COG2096	Adenosyltransferase
hmeg3_RS04830	COG0277	FAD linked oxidase domain protein
hmeg3_RS04835	COG0583	DNA-binding transcription factor activity
hmeg3_RS04840	COG0277	FAD linked oxidase domain protein
hmeg3_RS04845	COG0277	FAD linked oxidase domain protein
hmeg3_RS04850	COG0247	lactate metabolic process
hmeg3_RS04875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
hmeg3_RS04880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
hmeg3_RS04890	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS04900	COG0583	DNA-binding transcription factor activity
hmeg3_RS04905	COG3284	Transcriptional regulator
hmeg3_RS04910	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
hmeg3_RS04920	COG0386	Belongs to the glutathione peroxidase family
hmeg3_RS04940	COG4942	peptidase
hmeg3_RS04945	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
hmeg3_RS04950	COG1653	transport
hmeg3_RS04955	COG1175	transmembrane transport
hmeg3_RS04960	COG0395	ABC-type sugar transport system, permease component
hmeg3_RS04970	COG0251	oxidation-reduction process
hmeg3_RS04975	COG0583	DNA-binding transcription factor activity
hmeg3_RS04980	COG0179	Fumarylacetoacetate (FAA) hydrolase
hmeg3_RS04985	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
hmeg3_RS05000	COG0625	glutathione transferase activity
hmeg3_RS05010	COG0583	DNA-binding transcription factor activity
hmeg3_RS05030	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
hmeg3_RS05035	COG0343	queuine tRNA-ribosyltransferase activity
hmeg3_RS05045	COG4948	Mandelate Racemase Muconate Lactonizing
hmeg3_RS05050	COG2186	Transcriptional regulator
hmeg3_RS05060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
hmeg3_RS05065	COG1862	Preprotein translocase
hmeg3_RS05070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
hmeg3_RS05075	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
hmeg3_RS05080	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
hmeg3_RS05085	COG3550	peptidyl-serine autophosphorylation
hmeg3_RS05090	COG0405	Gamma-glutamyltransferase
hmeg3_RS05095	COG1609	Transcriptional regulator
hmeg3_RS05105	COG1070	Carbohydrate kinase
hmeg3_RS05110	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS05115	COG1063	alcohol dehydrogenase
hmeg3_RS05130	COG0628	permease
hmeg3_RS05135	COG2203	Gaf domain
hmeg3_RS05135	COG5001	Diguanylate cyclase
hmeg3_RS05135	COG4251	negative regulation of phosphorylation
hmeg3_RS05135	COG3706	GGDEF domain
hmeg3_RS05140	COG1902	pentaerythritol trinitrate reductase activity
hmeg3_RS05150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
hmeg3_RS05150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
hmeg3_RS05200	COG2321	neutral zinc metallopeptidase
hmeg3_RS05215	COG0667	Aldo Keto reductase
hmeg3_RS05220	COG0840	transmembrane signaling receptor activity
hmeg3_RS05235	COG0559	Belongs to the binding-protein-dependent transport system permease family
hmeg3_RS05240	COG0559	Belongs to the binding-protein-dependent transport system permease family
hmeg3_RS05250	COG0410	ABC transporter
hmeg3_RS05255	COG4336	lyase activity
hmeg3_RS05275	COG0840	transmembrane signaling receptor activity
hmeg3_RS05295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
hmeg3_RS05305	COG1741	Belongs to the pirin family
hmeg3_RS05310	COG0583	DNA-binding transcription factor activity
hmeg3_RS05315	COG2207	Transcriptional regulator
hmeg3_RS05320	COG4191	Histidine kinase
hmeg3_RS05360	COG0783	Belongs to the Dps family
hmeg3_RS05370	COG4566	intracellular signal transduction
hmeg3_RS05385	COG0840	transmembrane signaling receptor activity
hmeg3_RS05390	COG3850	Histidine kinase
hmeg3_RS05395	COG2197	response regulator
hmeg3_RS05415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
hmeg3_RS05420	COG4191	Histidine kinase
hmeg3_RS05425	COG4566	intracellular signal transduction
hmeg3_RS05445	COG2925	Exonuclease
hmeg3_RS05460	COG2329	Antibiotic biosynthesis monooxygenase
hmeg3_RS05470	COG2233	PERMEase
hmeg3_RS05500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
hmeg3_RS05530	COG0584	glycerophosphoryl diester phosphodiesterase
hmeg3_RS05545	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
hmeg3_RS05555	COG0425	Belongs to the sulfur carrier protein TusA family
hmeg3_RS05560	COG0069	glutamate synthase activity
hmeg3_RS05570	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
hmeg3_RS05575	COG1187	pseudouridine synthase activity
hmeg3_RS05580	COG0779	Required for maturation of 30S ribosomal subunits
hmeg3_RS05585	COG2251	uridine kinase activity
hmeg3_RS05585	COG0195	Participates in both transcription termination and antitermination
hmeg3_RS05590	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
hmeg3_RS05595	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
hmeg3_RS05610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
hmeg3_RS05620	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
hmeg3_RS05625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
hmeg3_RS05630	COG0436	Aminotransferase
hmeg3_RS05635	COG0741	lytic transglycosylase activity
hmeg3_RS05640	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
hmeg3_RS05650	COG5002	protein histidine kinase activity
hmeg3_RS05660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
hmeg3_RS05675	COG1609	Transcriptional regulator
hmeg3_RS05680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
hmeg3_RS05695	COG1850	ribulose-bisphosphate carboxylase activity
hmeg3_RS05705	COG1960	acyl-CoA dehydrogenase activity
hmeg3_RS05725	COG4681	YaeQ
hmeg3_RS05730	COG2079	MmgE PrpD family protein
hmeg3_RS05750	COG0010	Belongs to the arginase family
hmeg3_RS05770	COG2951	lytic endotransglycosylase activity
hmeg3_RS05775	COG0123	including yeast histone deacetylase and acetoin utilization protein
hmeg3_RS05785	COG0477	Major facilitator Superfamily
hmeg3_RS05790	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
hmeg3_RS05810	COG2011	ABC-type metal ion transport system permease component
hmeg3_RS05815	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
hmeg3_RS05825	COG0459	protein refolding
hmeg3_RS05830	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
hmeg3_RS05835	COG4948	Mandelate Racemase Muconate Lactonizing
hmeg3_RS05840	COG2814	Major facilitator Superfamily
hmeg3_RS05850	COG0579	oxidoreductase
hmeg3_RS05855	COG5001	Diguanylate cyclase
hmeg3_RS05855	COG4251	negative regulation of phosphorylation
hmeg3_RS05855	COG2203	Gaf domain
hmeg3_RS05855	COG3706	GGDEF domain
hmeg3_RS05865	COG0784	Response regulator, receiver
hmeg3_RS05865	COG0835	chemotaxis
hmeg3_RS05880	COG0387	Pfam Sodium calcium exchanger
hmeg3_RS05885	COG3530	Putative quorum-sensing-regulated virulence factor
hmeg3_RS05890	COG2203	Gaf domain
hmeg3_RS05890	COG3706	GGDEF domain
hmeg3_RS05890	COG4251	negative regulation of phosphorylation
hmeg3_RS05890	COG5001	Diguanylate cyclase
hmeg3_RS05915	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
hmeg3_RS05915	COG2885	chlorophyll binding
hmeg3_RS05920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
hmeg3_RS05935	COG1408	metallophosphoesterase
hmeg3_RS05945	COG0477	Major facilitator Superfamily
hmeg3_RS05950	COG0583	DNA-binding transcription factor activity
hmeg3_RS05955	COG1902	pentaerythritol trinitrate reductase activity
hmeg3_RS05970	COG1309	transcriptional regulator
hmeg3_RS05975	COG2130	NADP-dependent
hmeg3_RS05980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
hmeg3_RS06010	COG0559	Belongs to the binding-protein-dependent transport system permease family
hmeg3_RS06045	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
hmeg3_RS06050	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
hmeg3_RS06055	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
hmeg3_RS06060	COG2205	protein histidine kinase activity
hmeg3_RS06065	COG0745	RESPONSE REGULATOR receiver
hmeg3_RS06100	COG1116	anion transmembrane transporter activity
hmeg3_RS06120	COG1253	flavin adenine dinucleotide binding
hmeg3_RS06125	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS06130	COG4689	acetoacetate decarboxylase
hmeg3_RS06145	COG0297	glycogen (starch) synthase activity
hmeg3_RS06150	COG0840	transmembrane signaling receptor activity
hmeg3_RS06175	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
hmeg3_RS06180	COG0573	inorganic phosphate transmembrane transporter activity
hmeg3_RS06185	COG0581	inorganic phosphate transmembrane transporter activity
hmeg3_RS06190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
hmeg3_RS06195	COG0704	Plays a role in the regulation of phosphate uptake
hmeg3_RS06205	COG5002	protein histidine kinase activity
hmeg3_RS06215	COG2207	Transcriptional regulator
hmeg3_RS06230	COG1012	belongs to the aldehyde dehydrogenase family
hmeg3_RS06260	COG2084	Dehydrogenase
hmeg3_RS06265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
hmeg3_RS06275	COG2223	nitrite transmembrane transporter activity
hmeg3_RS06280	COG0596	Alpha beta hydrolase
hmeg3_RS06310	COG1764	response to oxidative stress
hmeg3_RS06315	COG1846	Transcriptional regulator
hmeg3_RS06330	COG0583	DNA-binding transcription factor activity
hmeg3_RS06340	COG0840	transmembrane signaling receptor activity
hmeg3_RS06345	COG2271	Major facilitator Superfamily
hmeg3_RS06350	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS06375	COG0280	phosphate acetyltransferase
hmeg3_RS06375	COG0281	malic enzyme
hmeg3_RS06390	COG1846	Transcriptional regulator
hmeg3_RS06395	COG1309	transcriptional regulator
hmeg3_RS06415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
hmeg3_RS06420	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS06430	COG4191	Histidine kinase
hmeg3_RS06430	COG0784	Response regulator, receiver
hmeg3_RS06460	COG0500	methyltransferase
hmeg3_RS06470	COG0745	RESPONSE REGULATOR receiver
hmeg3_RS06475	COG2205	protein histidine kinase activity
hmeg3_RS06500	COG1309	transcriptional regulator
hmeg3_RS06505	COG1752	Esterase of the alpha-beta hydrolase superfamily
hmeg3_RS06510	COG0791	NLP P60 protein
hmeg3_RS06515	COG3193	protein, possibly involved in utilization of glycolate and propanediol
hmeg3_RS06520	COG0505	Belongs to the CarA family
hmeg3_RS06525	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
hmeg3_RS06530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
hmeg3_RS06535	COG1534	Rna-binding protein
hmeg3_RS06540	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
hmeg3_RS06545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
hmeg3_RS06550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
hmeg3_RS06555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
hmeg3_RS06590	COG0488	(ABC) transporter
hmeg3_RS06600	COG0728	peptidoglycan biosynthetic process
hmeg3_RS06605	COG0268	Binds directly to 16S ribosomal RNA
hmeg3_RS06630	COG1278	Cold shock
hmeg3_RS06635	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
hmeg3_RS06640	COG0542	response to heat
hmeg3_RS06650	COG0756	dUTP diphosphatase activity
hmeg3_RS06655	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
hmeg3_RS06660	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
hmeg3_RS06665	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
hmeg3_RS06670	COG0196	riboflavin kinase activity
hmeg3_RS06705	COG0454	-acetyltransferase
hmeg3_RS06710	COG1802	Transcriptional regulator
hmeg3_RS06725	COG3845	ABC transporter
hmeg3_RS06730	COG1335	isochorismatase
hmeg3_RS06735	COG1079	Belongs to the binding-protein-dependent transport system permease family
hmeg3_RS06755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
hmeg3_RS06760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
hmeg3_RS06775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
hmeg3_RS06790	COG0456	acetyltransferase
hmeg3_RS06795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
hmeg3_RS06805	COG2226	methyltransferase
hmeg3_RS06810	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
hmeg3_RS06820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
hmeg3_RS06825	COG0312	modulator of DNA gyrase
hmeg3_RS06830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
hmeg3_RS06835	COG0745	RESPONSE REGULATOR receiver
hmeg3_RS06840	COG5002	protein histidine kinase activity
hmeg3_RS06850	COG1666	GTP binding
hmeg3_RS06855	COG0812	UDP-N-acetylmuramate dehydrogenase activity
hmeg3_RS06860	COG3123	guanosine phosphorylase activity
hmeg3_RS06865	COG0137	argininosuccinate synthase activity
hmeg3_RS06875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
hmeg3_RS06890	COG2154	pterin-4-alpha-carbinolamine dehydratase
hmeg3_RS06895	COG0501	Belongs to the peptidase M48B family
hmeg3_RS06900	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
hmeg3_RS06915	COG3012	SEC-C Motif Domain Protein
hmeg3_RS06915	COG3318	Belongs to the UPF0149 family
hmeg3_RS06925	COG0519	Catalyzes the synthesis of GMP from XMP
hmeg3_RS06940	COG1132	(ABC) transporter
hmeg3_RS06945	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
hmeg3_RS06950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
hmeg3_RS06955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
hmeg3_RS06960	COG2995	paraquat-inducible protein a
hmeg3_RS06965	COG2995	paraquat-inducible protein a
hmeg3_RS06970	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
hmeg3_RS06970	COG3008	intermembrane lipid transfer
hmeg3_RS06980	COG0513	Belongs to the DEAD box helicase family
hmeg3_RS06990	COG4166	transmembrane transport
hmeg3_RS06995	COG4174	ABC transporter (Permease)
hmeg3_RS07000	COG4239	(ABC) transporter, permease
hmeg3_RS07005	COG4172	Belongs to the ABC transporter superfamily
hmeg3_RS07010	COG1869	D-ribose catabolic process
hmeg3_RS07015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
hmeg3_RS07020	COG1609	Transcriptional regulator
hmeg3_RS07025	COG1172	Belongs to the binding-protein-dependent transport system permease family
hmeg3_RS07030	COG1129	ABC transporter
hmeg3_RS07040	COG1388	LysM domain
hmeg3_RS07040	COG0741	lytic transglycosylase activity
hmeg3_RS07045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
hmeg3_RS07055	COG0328	RNA-DNA hybrid ribonuclease activity
hmeg3_RS07060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
hmeg3_RS07080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
hmeg3_RS07085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
hmeg3_RS07095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
hmeg3_RS07105	COG3128	pkhd-type hydroxylase
hmeg3_RS07110	COG4774	siderophore transport
hmeg3_RS07130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
hmeg3_RS07140	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
hmeg3_RS07150	COG3706	GGDEF domain
hmeg3_RS07155	COG1742	UPF0060 membrane protein
hmeg3_RS07175	COG1704	LemA family
hmeg3_RS07180	COG0284	orotidine-5'-phosphate decarboxylase activity
hmeg3_RS07185	COG1546	Belongs to the CinA family
hmeg3_RS07190	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
hmeg3_RS07210	COG0400	carboxylic ester hydrolase activity
hmeg3_RS07220	COG0521	Mo-molybdopterin cofactor biosynthetic process
hmeg3_RS07225	COG3028	Belongs to the UPF0307 family
hmeg3_RS07230	COG0312	modulator of DNA gyrase
hmeg3_RS07240	COG0477	Major facilitator Superfamily
hmeg3_RS07245	COG1942	4-Oxalocrotonate Tautomerase
hmeg3_RS07250	COG0235	Class ii aldolase
hmeg3_RS07320	COG5001	Diguanylate cyclase
hmeg3_RS07320	COG2203	Gaf domain
hmeg3_RS07320	COG3706	GGDEF domain
hmeg3_RS07320	COG4251	negative regulation of phosphorylation
hmeg3_RS07345	COG1739	Uncharacterized protein family UPF0029
hmeg3_RS07375	COG1280	lysine exporter protein (LysE YggA)
hmeg3_RS07400	COG0840	transmembrane signaling receptor activity
hmeg3_RS07405	COG0477	Major facilitator Superfamily
hmeg3_RS07410	COG4191	Histidine kinase
hmeg3_RS07415	COG2204	response regulator
hmeg3_RS07435	COG1733	regulation of RNA biosynthetic process
hmeg3_RS07440	COG0500	methyltransferase
hmeg3_RS07525	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
hmeg3_RS07540	COG1473	amidohydrolase
hmeg3_RS07555	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS07595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
hmeg3_RS07615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
hmeg3_RS07635	COG0697	spore germination
hmeg3_RS07645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
hmeg3_RS07680	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
hmeg3_RS07680	COG2755	lipolytic protein G-D-S-L family
hmeg3_RS07700	COG0251	oxidation-reduction process
hmeg3_RS07705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
hmeg3_RS07720	COG4115	mRNA cleavage
hmeg3_RS07725	COG1802	Transcriptional regulator
hmeg3_RS07730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
hmeg3_RS07735	COG2271	Major facilitator Superfamily
hmeg3_RS07745	COG0247	lactate metabolic process
hmeg3_RS07750	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
hmeg3_RS07755	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
hmeg3_RS07760	COG0291	Belongs to the bacterial ribosomal protein bL35 family
hmeg3_RS07765	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
hmeg3_RS07770	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
hmeg3_RS07775	COG0072	phenylalanine-tRNA ligase activity
hmeg3_RS07775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
hmeg3_RS07780	COG0776	regulation of translation
hmeg3_RS07800	COG1442	glycosyl transferase family 8
hmeg3_RS07800	COG1216	Glycosyl transferase, family 2
hmeg3_RS07805	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
hmeg3_RS07810	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
hmeg3_RS07855	COG0489	protein tyrosine kinase activity
hmeg3_RS07855	COG3206	protein involved in exopolysaccharide biosynthesis
hmeg3_RS07870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
hmeg3_RS07875	COG1929	Belongs to the glycerate kinase type-1 family
hmeg3_RS07935	COG1136	(ABC) transporter
hmeg3_RS07950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
hmeg3_RS07955	COG0803	Belongs to the bacterial solute-binding protein 9 family
hmeg3_RS07965	COG0583	DNA-binding transcription factor activity
hmeg3_RS07990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
hmeg3_RS07995	COG0179	Fumarylacetoacetate (FAA) hydrolase
hmeg3_RS08010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
hmeg3_RS08025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
hmeg3_RS08035	COG0778	Nitroreductase
hmeg3_RS08040	COG0730	response to heat
hmeg3_RS08045	COG0840	transmembrane signaling receptor activity
hmeg3_RS08055	COG0556	nucleotide-excision repair
hmeg3_RS08075	COG1959	2 iron, 2 sulfur cluster binding
hmeg3_RS08090	COG0784	Response regulator, receiver
hmeg3_RS08090	COG4191	Histidine kinase
hmeg3_RS08110	COG0840	transmembrane signaling receptor activity
hmeg3_RS08120	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
hmeg3_RS08125	COG2201	protein-glutamate methylesterase activity
hmeg3_RS08130	COG0745	RESPONSE REGULATOR receiver
hmeg3_RS08135	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
hmeg3_RS08145	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
hmeg3_RS08160	COG1191	sigma factor activity
hmeg3_RS08165	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
hmeg3_RS08170	COG1360	Flagellar Motor Protein
hmeg3_RS08190	COG1815	bacterial-type flagellum-dependent cell motility
hmeg3_RS08195	COG1558	bacterial-type flagellum-dependent cell motility
hmeg3_RS08200	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
hmeg3_RS08220	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
hmeg3_RS08225	COG1706	bacterial-type flagellum-dependent cell motility
hmeg3_RS08230	COG3951	Flagellar rod assembly protein muramidase FlgJ
hmeg3_RS08230	COG1705	Flagellar rod assembly protein muramidase FlgJ
hmeg3_RS08245	COG1538	Outer membrane efflux protein
hmeg3_RS08250	COG1136	(ABC) transporter
hmeg3_RS08250	COG0577	efflux transmembrane transporter activity
hmeg3_RS08255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
hmeg3_RS08265	COG1987	bacterial-type flagellum assembly
hmeg3_RS08270	COG1338	Plays a role in the flagellum-specific transport system
hmeg3_RS08280	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
hmeg3_RS08290	COG1580	Controls the rotational direction of flagella during chemotaxis
hmeg3_RS08305	COG1157	protein secretion by the type III secretion system
hmeg3_RS08315	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
hmeg3_RS08320	COG1766	The M ring may be actively involved in energy transduction
hmeg3_RS08325	COG1677	Flagellar hook-basal body complex protein FliE
hmeg3_RS08330	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
hmeg3_RS08335	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
hmeg3_RS08350	COG1516	flagellar protein fliS
hmeg3_RS08355	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
hmeg3_RS08365	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
hmeg3_RS08375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
hmeg3_RS08380	COG0360	Binds together with S18 to 16S ribosomal RNA
hmeg3_RS08390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
hmeg3_RS08395	COG0359	binds to the 23S rRNA
hmeg3_RS08400	COG0305	Participates in initiation and elongation during chromosome replication
hmeg3_RS08410	COG0306	phosphate transporter
hmeg3_RS08415	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
hmeg3_RS08420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
hmeg3_RS08425	COG0726	polysaccharide deacetylase
hmeg3_RS08430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
hmeg3_RS08430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
hmeg3_RS08440	COG0463	Glycosyl transferase, family 2
hmeg3_RS08445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
hmeg3_RS08450	COG2076	Multidrug Resistance protein
hmeg3_RS08465	COG0436	Aminotransferase
hmeg3_RS08485	COG0583	DNA-binding transcription factor activity
hmeg3_RS08490	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
hmeg3_RS08505	COG1278	Cold shock
hmeg3_RS08510	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
hmeg3_RS08515	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
hmeg3_RS08520	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
hmeg3_RS08525	COG0560	Phosphoserine phosphatase
hmeg3_RS08560	COG0625	glutathione transferase activity
hmeg3_RS08570	COG1024	Enoyl-CoA hydratase
hmeg3_RS08575	COG0436	Aminotransferase
hmeg3_RS08595	COG3022	response to hydroperoxide
hmeg3_RS08600	COG0840	transmembrane signaling receptor activity
hmeg3_RS08610	COG0564	pseudouridine synthase activity
hmeg3_RS08640	COG3243	poly(R)-hydroxyalkanoic acid synthase
hmeg3_RS08645	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS08655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
hmeg3_RS08665	COG0626	cystathionine gamma-synthase activity
hmeg3_RS08690	COG1360	Flagellar Motor Protein
hmeg3_RS08700	COG0745	RESPONSE REGULATOR receiver
hmeg3_RS08710	COG0835	chemotaxis
hmeg3_RS08725	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
hmeg3_RS08745	COG2188	Transcriptional regulator
hmeg3_RS08755	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
hmeg3_RS08760	COG1053	succinate dehydrogenase
hmeg3_RS08765	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
hmeg3_RS08770	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
hmeg3_RS08775	COG0372	Belongs to the citrate synthase family
hmeg3_RS08780	COG0567	Dehydrogenase, E1 component
hmeg3_RS08785	COG0508	dehydrogenase complex catalyzes the overall conversion of
hmeg3_RS08790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
hmeg3_RS08795	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
hmeg3_RS08810	COG1199	ATP-dependent helicase activity
hmeg3_RS08820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
hmeg3_RS08825	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
hmeg3_RS08830	COG4942	peptidase
hmeg3_RS08830	COG1388	LysM domain
hmeg3_RS08835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
hmeg3_RS08840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
hmeg3_RS08850	COG0105	UTP biosynthetic process
hmeg3_RS08855	COG0820	rRNA (adenine-C2-)-methyltransferase activity
hmeg3_RS08870	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
hmeg3_RS08875	COG0124	histidyl-tRNA synthetase
hmeg3_RS08890	COG1160	GTP binding
hmeg3_RS08895	COG1923	regulation of RNA biosynthetic process
hmeg3_RS08900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
hmeg3_RS08905	COG0330	HflC and HflK could
hmeg3_RS08910	COG0330	HflC and HflK could
hmeg3_RS08915	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
hmeg3_RS08920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
hmeg3_RS08925	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
hmeg3_RS08935	COG2814	Major facilitator Superfamily
hmeg3_RS08940	COG0583	DNA-binding transcription factor activity
hmeg3_RS08965	COG0557	exoribonuclease II activity
hmeg3_RS08970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
hmeg3_RS08975	COG1045	serine acetyltransferase
hmeg3_RS08980	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
hmeg3_RS08985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
hmeg3_RS09005	COG0215	cysteine-tRNA ligase activity
hmeg3_RS09015	COG0825	malonyl-CoA metabolic process
hmeg3_RS09020	COG0037	tRNA processing
hmeg3_RS09040	COG1280	lysine exporter protein (LysE YggA)
hmeg3_RS09060	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
hmeg3_RS09080	COG0303	'Molybdopterin
hmeg3_RS09085	COG0746	molybdenum cofactor guanylyltransferase activity
hmeg3_RS09090	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
hmeg3_RS09095	COG1530	ribonuclease E activity
hmeg3_RS09125	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
hmeg3_RS09130	COG0248	Ppx GppA phosphatase
hmeg3_RS09135	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
hmeg3_RS09140	COG3064	Membrane
hmeg3_RS09155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
hmeg3_RS09165	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
hmeg3_RS09180	COG1301	dicarboxylic acid transport
hmeg3_RS09220	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
hmeg3_RS09235	COG1136	(ABC) transporter
hmeg3_RS09245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
hmeg3_RS09250	COG0084	hydrolase, TatD family'
hmeg3_RS09260	COG2267	carboxylic ester hydrolase activity
hmeg3_RS09265	COG0504	CTP synthase activity
hmeg3_RS09270	COG2877	3-deoxy-8-phosphooctulonate synthase activity
hmeg3_RS09275	COG0148	phosphopyruvate hydratase activity
hmeg3_RS09280	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
hmeg3_RS09285	COG3201	nicotinamide mononucleotide transporter
hmeg3_RS09295	COG2197	response regulator
hmeg3_RS09325	COG0840	transmembrane signaling receptor activity
hmeg3_RS09330	COG0483	inositol monophosphate 1-phosphatase activity
hmeg3_RS09345	COG1012	belongs to the aldehyde dehydrogenase family
hmeg3_RS09355	COG1802	Transcriptional regulator
hmeg3_RS09360	COG1840	ABC-type Fe3 transport system, periplasmic component
hmeg3_RS09365	COG3842	ATPase activity
hmeg3_RS09375	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
hmeg3_RS09385	COG4633	Protein conserved in bacteria
hmeg3_RS09390	COG0672	)-iron permease
hmeg3_RS09410	COG0402	S-adenosylhomocysteine deaminase activity
hmeg3_RS09415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
hmeg3_RS09420	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
hmeg3_RS09425	COG4521	taurine ABC transporter
hmeg3_RS09430	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
hmeg3_RS09435	COG2011	ABC-type metal ion transport system permease component
hmeg3_RS09455	COG1116	anion transmembrane transporter activity
hmeg3_RS09465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
hmeg3_RS09475	COG2271	Major facilitator Superfamily
hmeg3_RS09490	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
hmeg3_RS09500	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS09510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
hmeg3_RS09515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
hmeg3_RS09525	COG1045	serine acetyltransferase
hmeg3_RS09545	COG0840	transmembrane signaling receptor activity
hmeg3_RS09550	COG1414	Transcriptional regulator
hmeg3_RS09565	COG0601	transmembrane transport
hmeg3_RS09570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
hmeg3_RS09580	COG4608	Belongs to the ABC transporter superfamily
hmeg3_RS09590	COG0582	viral genome integration into host DNA
hmeg3_RS09750	COG0527	aspartate kinase activity
hmeg3_RS09760	COG0583	DNA-binding transcription factor activity
hmeg3_RS09770	COG1214	PFAM Peptidase M22, glycoprotease
hmeg3_RS09775	COG0456	acetyltransferase
hmeg3_RS09780	COG1573	uracil-dna glycosylase
hmeg3_RS09795	COG0477	Major facilitator Superfamily
hmeg3_RS09800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
hmeg3_RS09830	COG0765	amino acid transport
hmeg3_RS09835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
hmeg3_RS09840	COG0488	(ABC) transporter
hmeg3_RS09845	COG2890	protein-(glutamine-N5) methyltransferase activity
hmeg3_RS09850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
hmeg3_RS09855	COG1393	Belongs to the ArsC family
hmeg3_RS09860	COG2171	N-acyltransferase activity
hmeg3_RS09870	COG0840	transmembrane signaling receptor activity
hmeg3_RS09885	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
hmeg3_RS09890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
hmeg3_RS09895	COG0242	peptide deformylase activity
hmeg3_RS09900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
hmeg3_RS09900	COG0189	ligase activity
hmeg3_RS09905	COG1181	Belongs to the D-alanine--D-alanine ligase family
hmeg3_RS09905	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
hmeg3_RS09910	COG1132	(ABC) transporter
hmeg3_RS09920	COG1187	pseudouridine synthase activity
hmeg3_RS09925	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
hmeg3_RS09930	COG0024	Methionine aminopeptidase
hmeg3_RS09935	COG0052	Belongs to the universal ribosomal protein uS2 family
hmeg3_RS09940	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
hmeg3_RS09945	COG0528	UMP kinase activity
hmeg3_RS09950	COG0233	cytoplasmic translational termination
hmeg3_RS09955	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
hmeg3_RS09960	COG0575	Belongs to the CDS family
hmeg3_RS09965	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
hmeg3_RS09970	COG0750	zinc metalloprotease
hmeg3_RS09975	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
hmeg3_RS09985	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
hmeg3_RS09990	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
hmeg3_RS09995	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
hmeg3_RS10000	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
hmeg3_RS10005	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
hmeg3_RS10010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
hmeg3_RS10020	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
hmeg3_RS10035	COG0330	HflC and HflK could
hmeg3_RS10040	COG2205	protein histidine kinase activity
hmeg3_RS10045	COG0745	RESPONSE REGULATOR receiver
hmeg3_RS10060	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
hmeg3_RS10065	COG2867	negative regulation of translational initiation
hmeg3_RS10070	COG2914	Belongs to the UPF0125 (RnfH) family
hmeg3_RS10080	COG0519	Catalyzes the synthesis of GMP from XMP
hmeg3_RS10080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
hmeg3_RS10085	COG1944	ATP diphosphatase activity
hmeg3_RS10100	COG1309	transcriptional regulator
hmeg3_RS10115	COG0602	queuosine metabolic process
hmeg3_RS10120	COG0720	synthase
hmeg3_RS10130	COG1619	proteins homologs of microcin C7 resistance protein MccF
hmeg3_RS10140	COG0488	(ABC) transporter
hmeg3_RS10145	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
hmeg3_RS10175	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
hmeg3_RS10180	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
hmeg3_RS10185	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
hmeg3_RS10190	COG2197	response regulator
hmeg3_RS10265	COG2851	Citrate transporter
hmeg3_RS10270	COG0583	DNA-binding transcription factor activity
hmeg3_RS10275	COG0477	Major facilitator Superfamily
hmeg3_RS10295	COG2153	protein acetylation
hmeg3_RS10300	COG1301	dicarboxylic acid transport
hmeg3_RS10320	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
hmeg3_RS10325	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
hmeg3_RS10330	COG0470	DNA polymerase III
hmeg3_RS10335	COG1247	-acetyltransferase
hmeg3_RS10350	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
hmeg3_RS10365	COG0084	hydrolase, TatD family'
hmeg3_RS10390	COG1562	ergosterol biosynthetic process
hmeg3_RS10400	COG0513	Belongs to the DEAD box helicase family
hmeg3_RS10420	COG1562	ergosterol biosynthetic process
hmeg3_RS10435	COG3045	CreA protein
hmeg3_RS10445	COG0544	peptidyl-prolyl cis-trans isomerase activity
hmeg3_RS10450	COG0740	serine-type endopeptidase activity
hmeg3_RS10455	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
hmeg3_RS10460	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
hmeg3_RS10515	COG4251	negative regulation of phosphorylation
hmeg3_RS10520	COG4585	Histidine kinase
hmeg3_RS10535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
hmeg3_RS10580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
hmeg3_RS10595	COG4181	ATPase activity
hmeg3_RS10605	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
hmeg3_RS10605	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
hmeg3_RS10610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
hmeg3_RS10620	COG0583	DNA-binding transcription factor activity
hmeg3_RS10625	COG0604	alcohol dehydrogenase
hmeg3_RS10630	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
hmeg3_RS10630	COG0047	phosphoribosylformylglycinamidine synthase activity
hmeg3_RS10645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
hmeg3_RS10655	COG2917	probably involved in intracellular septation
hmeg3_RS10660	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
hmeg3_RS10665	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
hmeg3_RS10680	COG2271	Major facilitator Superfamily
hmeg3_RS10690	COG1012	belongs to the aldehyde dehydrogenase family
hmeg3_RS10695	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS10715	COG1840	ABC-type Fe3 transport system, periplasmic component
hmeg3_RS10720	COG1178	ABC-type Fe3 transport system permease component
hmeg3_RS10725	COG3842	ATPase activity
hmeg3_RS10750	COG2871	sodium ion transport
hmeg3_RS10755	COG2203	Gaf domain
hmeg3_RS10755	COG3706	GGDEF domain
hmeg3_RS10755	COG4251	negative regulation of phosphorylation
hmeg3_RS10755	COG5001	Diguanylate cyclase
hmeg3_RS10780	COG2329	Antibiotic biosynthesis monooxygenase
hmeg3_RS10795	COG1960	acyl-CoA dehydrogenase activity
hmeg3_RS10800	COG1024	Enoyl-CoA hydratase
hmeg3_RS10815	COG0417	DNA replication proofreading
hmeg3_RS10820	COG3708	Transcriptional regulator
hmeg3_RS10820	COG2207	Transcriptional regulator
hmeg3_RS10840	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
hmeg3_RS10845	COG1597	lipid kinase activity
hmeg3_RS10850	COG0671	phosphoesterase, PA-phosphatase related
hmeg3_RS10855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
hmeg3_RS10860	COG1335	isochorismatase
hmeg3_RS10865	COG2814	Major facilitator Superfamily
hmeg3_RS10870	COG4977	sequence-specific DNA binding
hmeg3_RS10875	COG0583	DNA-binding transcription factor activity
hmeg3_RS10890	COG1741	Belongs to the pirin family
hmeg3_RS10895	COG0589	response to stress
hmeg3_RS10905	COG2890	protein-(glutamine-N5) methyltransferase activity
hmeg3_RS10915	COG0583	DNA-binding transcription factor activity
hmeg3_RS10930	COG0642	Histidine kinase
hmeg3_RS10940	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
hmeg3_RS10945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
hmeg3_RS10955	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
hmeg3_RS10960	COG0395	ABC-type sugar transport system, permease component
hmeg3_RS10970	COG1653	transport
hmeg3_RS10975	COG3842	ATPase activity
hmeg3_RS10980	COG1349	DNA-binding transcription factor activity
hmeg3_RS11005	COG0583	DNA-binding transcription factor activity
hmeg3_RS11010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
hmeg3_RS11015	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
hmeg3_RS11020	COG2971	BadF BadG BcrA BcrD
hmeg3_RS11025	COG3842	ATPase activity
hmeg3_RS11030	COG0395	ABC-type sugar transport system, permease component
hmeg3_RS11035	COG1175	transmembrane transport
hmeg3_RS11070	COG1104	cysteine desulfurase activity
hmeg3_RS11075	COG0583	DNA-binding transcription factor activity
hmeg3_RS11080	COG2072	flavoprotein involved in K transport
hmeg3_RS11085	COG0601	transmembrane transport
hmeg3_RS11090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
hmeg3_RS11095	COG0444	Belongs to the ABC transporter superfamily
hmeg3_RS11100	COG4608	Belongs to the ABC transporter superfamily
hmeg3_RS11105	COG0747	negative chemotaxis
hmeg3_RS11125	COG0509	glycine decarboxylation via glycine cleavage system
hmeg3_RS11130	COG0210	DNA helicase
hmeg3_RS11145	COG0583	DNA-binding transcription factor activity
hmeg3_RS11150	COG3193	protein, possibly involved in utilization of glycolate and propanediol
hmeg3_RS11175	COG1301	dicarboxylic acid transport
hmeg3_RS11185	COG2986	histidine ammonia-lyase
hmeg3_RS11190	COG0840	transmembrane signaling receptor activity
hmeg3_RS11200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
hmeg3_RS11205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
hmeg3_RS11210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
hmeg3_RS11225	COG3258	Cytochrome c
hmeg3_RS11235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
hmeg3_RS11240	COG0477	Major facilitator Superfamily
hmeg3_RS11245	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
hmeg3_RS11250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
hmeg3_RS11255	COG1845	cytochrome c oxidase, subunit III
hmeg3_RS11260	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
hmeg3_RS11265	COG3346	SURF1 family
hmeg3_RS11275	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
hmeg3_RS11285	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
hmeg3_RS11310	COG3360	Dodecin
hmeg3_RS11315	COG0297	glycogen (starch) synthase activity
hmeg3_RS11320	COG0366	Alpha amylase catalytic
hmeg3_RS11325	COG0366	Alpha amylase catalytic
hmeg3_RS11330	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
hmeg3_RS11345	COG1640	4-alpha-glucanotransferase
hmeg3_RS11365	COG3791	Glutathione-dependent formaldehyde-activating
hmeg3_RS11380	COG2198	Histidine kinase
hmeg3_RS11380	COG0643	Histidine kinase
hmeg3_RS11395	COG0745	RESPONSE REGULATOR receiver
hmeg3_RS11405	COG4302	ethanolamine ammonia-lyase activity
hmeg3_RS11420	COG0840	transmembrane signaling receptor activity
hmeg3_RS11435	COG2200	EAL domain
hmeg3_RS11470	COG0589	response to stress
hmeg3_RS11500	COG3706	GGDEF domain
hmeg3_RS11500	COG2203	Gaf domain
hmeg3_RS11500	COG4251	negative regulation of phosphorylation
hmeg3_RS11500	COG5001	Diguanylate cyclase
hmeg3_RS11505	COG0840	transmembrane signaling receptor activity
hmeg3_RS11510	COG0835	chemotaxis
hmeg3_RS11510	COG0784	Response regulator, receiver
hmeg3_RS11515	COG0840	transmembrane signaling receptor activity
hmeg3_RS11530	COG2198	Histidine kinase
hmeg3_RS11530	COG2205	protein histidine kinase activity
hmeg3_RS11530	COG0784	Response regulator, receiver
hmeg3_RS11545	COG2205	protein histidine kinase activity
hmeg3_RS11545	COG0784	Response regulator, receiver
hmeg3_RS11545	COG5002	protein histidine kinase activity
hmeg3_RS11565	COG3038	cytochrome b561
hmeg3_RS11580	COG2217	Heavy metal translocating P-type atpase
hmeg3_RS11590	COG3278	Belongs to the heme-copper respiratory oxidase family
hmeg3_RS11670	COG4774	siderophore transport
hmeg3_RS11690	COG0300	oxidoreductase activity
hmeg3_RS11690	COG0318	PFAM AMP-dependent synthetase and ligase
hmeg3_RS11690	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS11690	COG3321	synthase
hmeg3_RS11690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
hmeg3_RS11695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
hmeg3_RS11705	COG3597	protein domain associated with
hmeg3_RS11785	COG2207	Transcriptional regulator
hmeg3_RS11785	COG1917	Cupin 2, conserved barrel domain protein
hmeg3_RS11790	COG4221	oxidoreductase activity
hmeg3_RS11825	COG0789	Transcriptional regulator
hmeg3_RS11900	COG0840	transmembrane signaling receptor activity
hmeg3_RS11905	COG0642	Histidine kinase
hmeg3_RS11920	COG3038	cytochrome b561
hmeg3_RS11930	COG0671	phosphoesterase, PA-phosphatase related
hmeg3_RS11935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
hmeg3_RS11945	COG0038	chloride channel
hmeg3_RS11995	COG2985	domain, Protein
hmeg3_RS12005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
hmeg3_RS12020	COG1176	ABC-type spermidine putrescine transport system, permease component I
hmeg3_RS12025	COG1177	transmembrane transport
hmeg3_RS12045	COG2818	Glycosylase
hmeg3_RS12080	COG0667	Aldo Keto reductase
hmeg3_RS12095	COG1595	DNA-templated transcription, initiation
hmeg3_RS12100	COG0740	serine-type endopeptidase activity
hmeg3_RS12140	COG0791	NLP P60 protein
hmeg3_RS12145	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
hmeg3_RS12155	COG0765	amino acid transport
hmeg3_RS12160	COG0765	amino acid transport
hmeg3_RS12165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
hmeg3_RS12170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
hmeg3_RS12185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
hmeg3_RS12195	COG3047	cAMP biosynthetic process
hmeg3_RS12225	COG0835	chemotaxis
hmeg3_RS12225	COG0784	Response regulator, receiver
hmeg3_RS12235	COG0494	nUDIX hydrolase
hmeg3_RS12240	COG1349	DNA-binding transcription factor activity
hmeg3_RS12250	COG0840	transmembrane signaling receptor activity
hmeg3_RS12255	COG3604	Transcriptional regulator
hmeg3_RS12275	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
hmeg3_RS12285	COG1674	ftsk spoiiie
hmeg3_RS12295	COG3025	triphosphatase activity
hmeg3_RS12310	COG0596	Alpha beta hydrolase
hmeg3_RS12315	COG0583	DNA-binding transcription factor activity
hmeg3_RS12325	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
hmeg3_RS12360	COG1492	cobalamin metabolic process
hmeg3_RS12380	COG0778	Nitroreductase
hmeg3_RS12420	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
hmeg3_RS12425	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
hmeg3_RS12445	COG3411	Ferredoxin
hmeg3_RS12470	COG0840	transmembrane signaling receptor activity
hmeg3_RS12500	COG1210	Utp--glucose-1-phosphate uridylyltransferase
hmeg3_RS12530	COG0633	Ferredoxin
hmeg3_RS12530	COG3217	Mosc domain protein beta barrel domain protein
hmeg3_RS12540	COG0436	Aminotransferase
hmeg3_RS12545	COG0583	DNA-binding transcription factor activity
hmeg3_RS12575	COG1346	cytolysis
hmeg3_RS12585	COG1607	acyl-coa hydrolase
hmeg3_RS12590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
hmeg3_RS12595	COG1285	pathogenesis
hmeg3_RS12605	COG2203	Gaf domain
hmeg3_RS12605	COG5001	Diguanylate cyclase
hmeg3_RS12605	COG4251	negative regulation of phosphorylation
hmeg3_RS12605	COG3706	GGDEF domain
hmeg3_RS12635	COG3608	succinylglutamate desuccinylase aspartoacylase
hmeg3_RS12635	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
hmeg3_RS12650	COG0784	Response regulator, receiver
hmeg3_RS12655	COG2205	protein histidine kinase activity
hmeg3_RS12655	COG2202	Pas domain
hmeg3_RS12685	COG3052	prosthetic group binding
hmeg3_RS12705	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
hmeg3_RS12710	COG1802	Transcriptional regulator
hmeg3_RS12720	COG0583	DNA-binding transcription factor activity
hmeg3_RS12745	COG2375	cellular response to nickel ion
hmeg3_RS12755	COG0024	Methionine aminopeptidase
hmeg3_RS12770	COG0564	pseudouridine synthase activity
hmeg3_RS12775	COG3550	peptidyl-serine autophosphorylation
hmeg3_RS12845	COG1566	PFAM secretion protein HlyD family protein
hmeg3_RS12850	COG2814	Major facilitator Superfamily
hmeg3_RS12855	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
hmeg3_RS12870	COG0747	negative chemotaxis
hmeg3_RS12885	COG0667	Aldo Keto reductase
hmeg3_RS12910	COG1960	acyl-CoA dehydrogenase activity
hmeg3_RS12915	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
hmeg3_RS12930	COG0583	DNA-binding transcription factor activity
hmeg3_RS12975	COG1476	TRANSCRIPTIONal
hmeg3_RS12995	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
hmeg3_RS13000	COG0732	type I restriction modification DNA specificity domain
hmeg3_RS13005	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
hmeg3_RS13065	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
hmeg3_RS13070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
hmeg3_RS13090	COG0640	Transcriptional regulator
hmeg3_RS13095	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
hmeg3_RS13105	COG0431	NADPH-dependent FMN reductase
hmeg3_RS13125	COG3214	Protein conserved in bacteria
hmeg3_RS13130	COG0840	transmembrane signaling receptor activity
hmeg3_RS13145	COG3220	belongs to the UPF0276 family
hmeg3_RS13160	COG1309	transcriptional regulator
hmeg3_RS13165	COG1595	DNA-templated transcription, initiation
hmeg3_RS13170	COG4944	Protein of unknown function (DUF1109)
hmeg3_RS13185	COG2223	nitrite transmembrane transporter activity
hmeg3_RS13190	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
hmeg3_RS13195	COG2146	nitrite reductase [NAD(P)H] activity
hmeg3_RS13200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
hmeg3_RS13205	COG0243	molybdopterin cofactor binding
hmeg3_RS13210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
hmeg3_RS13220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
hmeg3_RS13225	COG4948	Mandelate Racemase Muconate Lactonizing
hmeg3_RS13250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
hmeg3_RS13255	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
hmeg3_RS13260	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
hmeg3_RS13265	COG1561	YicC-like family, N-terminal region
hmeg3_RS13275	COG1758	RNA polymerase activity
hmeg3_RS13280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
hmeg3_RS13285	COG0583	DNA-binding transcription factor activity
hmeg3_RS13290	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
hmeg3_RS13315	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
hmeg3_RS13320	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
hmeg3_RS13325	COG0038	chloride channel
hmeg3_RS13335	COG0725	ABC transporter, periplasmic molybdate-binding protein
hmeg3_RS13340	COG4149	molybdate abc transporter
hmeg3_RS13345	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
hmeg3_RS13350	COG2224	Isocitrate lyase
hmeg3_RS13360	COG1289	transmembrane transporter activity
hmeg3_RS13365	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
hmeg3_RS13370	COG0583	DNA-binding transcription factor activity
hmeg3_RS13375	COG3706	GGDEF domain
hmeg3_RS13380	COG0542	response to heat
hmeg3_RS13385	COG0431	NADPH-dependent FMN reductase
hmeg3_RS13390	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
hmeg3_RS13395	COG0583	DNA-binding transcription factor activity
hmeg3_RS13415	COG1566	PFAM secretion protein HlyD family protein
hmeg3_RS13425	COG0314	molybdopterin synthase activity
hmeg3_RS13450	COG0303	'Molybdopterin
hmeg3_RS13470	COG1280	lysine exporter protein (LysE YggA)
hmeg3_RS13490	COG0840	transmembrane signaling receptor activity
hmeg3_RS13510	COG0840	transmembrane signaling receptor activity
hmeg3_RS13520	COG0300	oxidoreductase activity
hmeg3_RS13540	COG0300	oxidoreductase activity
hmeg3_RS13545	COG0583	DNA-binding transcription factor activity
hmeg3_RS13575	COG1280	lysine exporter protein (LysE YggA)
hmeg3_RS13585	COG3706	GGDEF domain
hmeg3_RS13585	COG2203	Gaf domain
hmeg3_RS13585	COG4251	negative regulation of phosphorylation
hmeg3_RS13585	COG5001	Diguanylate cyclase
hmeg3_RS13595	COG0583	DNA-binding transcription factor activity
hmeg3_RS13605	COG0066	3-isopropylmalate dehydratase activity
hmeg3_RS13610	COG3493	citrate carrier protein
hmeg3_RS13620	COG2271	Major facilitator Superfamily
hmeg3_RS13625	COG0583	DNA-binding transcription factor activity
hmeg3_RS13630	COG0129	dihydroxy-acid dehydratase activity
hmeg3_RS13705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
hmeg3_RS13710	COG0494	nUDIX hydrolase
hmeg3_RS13720	COG1007	ATP synthesis coupled electron transport
hmeg3_RS13735	COG0713	ATP synthesis coupled electron transport
hmeg3_RS13745	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
hmeg3_RS13750	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
hmeg3_RS13755	COG1034	ATP synthesis coupled electron transport
hmeg3_RS13765	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
hmeg3_RS13770	COG0649	NAD binding
hmeg3_RS13775	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
hmeg3_RS13780	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
hmeg3_RS13785	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
hmeg3_RS13800	COG0149	triose-phosphate isomerase activity
hmeg3_RS13805	COG3321	synthase
hmeg3_RS13805	COG0604	alcohol dehydrogenase
hmeg3_RS13805	COG4221	oxidoreductase activity
hmeg3_RS13805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
hmeg3_RS13815	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
hmeg3_RS13820	COG1984	allophanate hydrolase subunit 2
hmeg3_RS13825	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
hmeg3_RS13845	COG1252	NADH dehydrogenase
hmeg3_RS13855	COG1185	polyribonucleotide nucleotidyltransferase activity
hmeg3_RS13860	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
hmeg3_RS13875	COG0251	oxidation-reduction process
hmeg3_RS13880	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
hmeg3_RS13905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
hmeg3_RS13915	COG3706	GGDEF domain
hmeg3_RS13935	COG1183	phosphatidylcholine synthase activity
hmeg3_RS13940	COG0688	phosphatidylethanolamine metabolic process
hmeg3_RS13950	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
hmeg3_RS13955	COG0440	acetolactate synthase activity
hmeg3_RS13960	COG0028	Belongs to the TPP enzyme family
hmeg3_RS13995	COG2833	Protein of unknown function (DUF455)
hmeg3_RS14005	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
hmeg3_RS14010	COG1187	pseudouridine synthase activity
hmeg3_RS14020	COG0483	inositol monophosphate 1-phosphatase activity
hmeg3_RS14030	COG2267	carboxylic ester hydrolase activity
hmeg3_RS14035	COG1733	regulation of RNA biosynthetic process
hmeg3_RS14050	COG0513	Belongs to the DEAD box helicase family
hmeg3_RS14090	COG0477	Major facilitator Superfamily
hmeg3_RS14110	COG1793	dna ligase
hmeg3_RS14115	COG1253	flavin adenine dinucleotide binding
hmeg3_RS14125	COG1477	protein flavinylation
hmeg3_RS14150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
hmeg3_RS14160	COG0243	molybdopterin cofactor binding
hmeg3_RS14180	COG0601	transmembrane transport
hmeg3_RS14185	COG0747	negative chemotaxis
hmeg3_RS14190	COG1846	Transcriptional regulator
hmeg3_RS14210	COG2223	nitrite transmembrane transporter activity
hmeg3_RS14215	COG3145	DNA-N1-methyladenine dioxygenase activity
hmeg3_RS14220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
hmeg3_RS14220	COG2169	Transcriptional regulator
hmeg3_RS14225	COG1522	sequence-specific DNA binding
hmeg3_RS14315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
hmeg3_RS14320	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
hmeg3_RS14325	COG0167	dihydroorotate dehydrogenase activity
hmeg3_RS14335	COG0765	amino acid transport
hmeg3_RS14350	COG2423	ornithine cyclodeaminase activity
hmeg3_RS14355	COG1522	sequence-specific DNA binding
hmeg3_RS14365	COG0583	DNA-binding transcription factor activity
hmeg3_RS14375	COG0583	DNA-binding transcription factor activity
hmeg3_RS14380	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
hmeg3_RS14385	COG4208	sulfate ABC transporter
hmeg3_RS14395	COG2186	Transcriptional regulator
hmeg3_RS14400	COG1904	glucuronate isomerase
hmeg3_RS14410	COG3842	ATPase activity
hmeg3_RS14425	COG0246	Mannitol dehydrogenase
hmeg3_RS14435	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS14450	COG3585	molybdate ion transport
hmeg3_RS14455	COG1116	anion transmembrane transporter activity
hmeg3_RS14460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
hmeg3_RS14465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
hmeg3_RS14470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
hmeg3_RS14475	COG0431	NADPH-dependent FMN reductase
hmeg3_RS14480	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
hmeg3_RS14510	COG2226	methyltransferase
hmeg3_RS14525	COG0123	including yeast histone deacetylase and acetoin utilization protein
hmeg3_RS14590	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
hmeg3_RS14595	COG0492	ferredoxin-NADP+ reductase activity
hmeg3_RS14605	COG2878	Part of a membrane complex involved in electron transport
hmeg3_RS14610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
hmeg3_RS14620	COG3539	Fimbrial protein
hmeg3_RS14650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
hmeg3_RS14670	COG2217	Heavy metal translocating P-type atpase
hmeg3_RS14675	COG0789	Transcriptional regulator
hmeg3_RS14680	COG0673	inositol 2-dehydrogenase activity
hmeg3_RS14685	COG0789	Transcriptional regulator
hmeg3_RS14695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
hmeg3_RS14750	COG0210	DNA helicase
hmeg3_RS14775	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
hmeg3_RS14780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
hmeg3_RS14810	COG0431	NADPH-dependent FMN reductase
hmeg3_RS14830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
hmeg3_RS14835	COG0640	Transcriptional regulator
hmeg3_RS14860	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
hmeg3_RS14870	COG0318	PFAM AMP-dependent synthetase and ligase
hmeg3_RS14875	COG3706	GGDEF domain
hmeg3_RS14875	COG4251	negative regulation of phosphorylation
hmeg3_RS14875	COG5001	Diguanylate cyclase
hmeg3_RS14875	COG2203	Gaf domain
hmeg3_RS14905	COG0840	transmembrane signaling receptor activity
hmeg3_RS14925	COG4269	membrane
hmeg3_RS14955	COG1309	transcriptional regulator
hmeg3_RS14980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
hmeg3_RS14985	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
hmeg3_RS14990	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
hmeg3_RS15030	COG1294	oxidase, subunit
hmeg3_RS15055	COG1454	alcohol dehydrogenase
hmeg3_RS15060	COG3485	protocatechuate 3,4-dioxygenase
hmeg3_RS15065	COG1764	response to oxidative stress
hmeg3_RS15070	COG1846	Transcriptional regulator
hmeg3_RS15090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
hmeg3_RS15110	COG2186	Transcriptional regulator
hmeg3_RS15120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
hmeg3_RS15140	COG0583	DNA-binding transcription factor activity
hmeg3_RS15150	COG1024	Enoyl-CoA hydratase
hmeg3_RS15170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
hmeg3_RS15180	COG0489	protein tyrosine kinase activity
hmeg3_RS15185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
hmeg3_RS15185	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
hmeg3_RS15195	COG2390	Transcriptional regulator
hmeg3_RS15210	COG1283	sodium-dependent phosphate transmembrane transporter activity
hmeg3_RS15235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
hmeg3_RS15240	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
hmeg3_RS15245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
hmeg3_RS15250	COG0840	transmembrane signaling receptor activity
hmeg3_RS15255	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
hmeg3_RS15260	COG4139	cobalamin transport
hmeg3_RS15265	COG4771	TonB-dependent receptor
hmeg3_RS15270	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
hmeg3_RS15275	COG0643	Histidine kinase
hmeg3_RS15275	COG0784	Response regulator, receiver
hmeg3_RS15275	COG2198	Histidine kinase
hmeg3_RS15285	COG0583	DNA-binding transcription factor activity
hmeg3_RS15290	COG0730	response to heat
hmeg3_RS15305	COG0175	sulfate reduction
hmeg3_RS15315	COG2895	sulfate adenylyltransferase (ATP) activity
hmeg3_RS15320	COG1648	precorrin-2 dehydrogenase activity
hmeg3_RS15320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
hmeg3_RS15325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
hmeg3_RS15335	COG0795	lipopolysaccharide-transporting ATPase activity
hmeg3_RS15340	COG0795	lipopolysaccharide-transporting ATPase activity
hmeg3_RS15345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
hmeg3_RS15365	COG2814	Major facilitator Superfamily
hmeg3_RS15395	COG0662	Cupin 2, conserved barrel domain protein
hmeg3_RS15410	COG1247	-acetyltransferase
hmeg3_RS15415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
hmeg3_RS15455	COG2204	response regulator
hmeg3_RS15460	COG3852	Histidine kinase
hmeg3_RS15470	COG0174	glutamine synthetase
hmeg3_RS15485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
hmeg3_RS15485	COG2205	protein histidine kinase activity
hmeg3_RS15490	COG2197	response regulator
hmeg3_RS15510	COG2975	iron-sulfur cluster assembly
hmeg3_RS15520	COG0443	Heat shock 70 kDa protein
hmeg3_RS15525	COG1280	lysine exporter protein (LysE YggA)
hmeg3_RS15530	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
hmeg3_RS15540	COG0822	iron-sulfur transferase activity
hmeg3_RS15545	COG1104	cysteine desulfurase activity
hmeg3_RS15565	COG0587	DNA-directed DNA polymerase activity
hmeg3_RS15575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
hmeg3_RS15580	COG1012	belongs to the aldehyde dehydrogenase family
hmeg3_RS15590	COG2706	6-phosphogluconolactonase activity
hmeg3_RS15595	COG2721	sulfolactate sulfo-lyase activity
hmeg3_RS15600	COG2271	Major facilitator Superfamily
hmeg3_RS15610	COG2010	Cytochrome c
hmeg3_RS15610	COG1529	Aldehyde oxidase and xanthine dehydrogenase
hmeg3_RS15615	COG2080	2 iron, 2 sulfur cluster binding
hmeg3_RS15630	COG0667	Aldo Keto reductase
hmeg3_RS15635	COG1414	Transcriptional regulator
hmeg3_RS15645	COG0765	amino acid transport
hmeg3_RS15650	COG1126	abc transporter atp-binding protein
hmeg3_RS15655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
hmeg3_RS15665	COG0702	epimerase
hmeg3_RS15670	COG1733	regulation of RNA biosynthetic process
hmeg3_RS15680	COG3459	Glycosyltransferase 36 associated
hmeg3_RS15705	COG2197	response regulator
hmeg3_RS15755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
hmeg3_RS15800	COG4790	Type iii secretion
hmeg3_RS15845	COG2207	Transcriptional regulator
hmeg3_RS15870	COG4943	cyclic-guanylate-specific phosphodiesterase activity
hmeg3_RS15885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
hmeg3_RS15900	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
hmeg3_RS15910	COG2201	protein-glutamate methylesterase activity
hmeg3_RS15930	COG0598	Magnesium transport protein CorA
hmeg3_RS15935	COG0697	spore germination
hmeg3_RS15940	COG0477	Major facilitator Superfamily
hmeg3_RS15945	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
hmeg3_RS15945	COG0512	Glutamine amidotransferase of anthranilate synthase
hmeg3_RS15965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
hmeg3_RS16005	COG0114	fumarate hydratase activity
hmeg3_RS16025	COG0335	large ribosomal subunit rRNA binding
hmeg3_RS16030	COG0336	Belongs to the RNA methyltransferase TrmD family
hmeg3_RS16035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
hmeg3_RS16040	COG0228	four-way junction DNA binding
hmeg3_RS16050	COG1960	acyl-CoA dehydrogenase activity
hmeg3_RS16070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
hmeg3_RS16085	COG0765	amino acid transport
hmeg3_RS16090	COG0765	amino acid transport
hmeg3_RS16095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
hmeg3_RS16100	COG1609	Transcriptional regulator
hmeg3_RS16105	COG4943	cyclic-guanylate-specific phosphodiesterase activity
hmeg3_RS16115	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
hmeg3_RS16120	COG3383	formate dehydrogenase (NAD+) activity
hmeg3_RS16135	COG2223	nitrite transmembrane transporter activity
hmeg3_RS16140	COG1910	domain protein
hmeg3_RS16145	COG0583	DNA-binding transcription factor activity
hmeg3_RS16150	COG0473	3-isopropylmalate dehydrogenase activity
hmeg3_RS16165	COG0531	amino acid
hmeg3_RS16185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
hmeg3_RS16190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
hmeg3_RS16205	COG1215	transferase activity, transferring glycosyl groups
hmeg3_RS16215	COG2986	histidine ammonia-lyase
hmeg3_RS16245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
hmeg3_RS16255	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS16260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
hmeg3_RS16285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
hmeg3_RS16295	COG0747	negative chemotaxis
hmeg3_RS16300	COG4172	Belongs to the ABC transporter superfamily
hmeg3_RS16320	COG0583	DNA-binding transcription factor activity
hmeg3_RS16340	COG0114	fumarate hydratase activity
hmeg3_RS16345	COG0840	transmembrane signaling receptor activity
hmeg3_RS16360	COG2188	Transcriptional regulator
hmeg3_RS16365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
hmeg3_RS16370	COG2814	Major facilitator Superfamily
hmeg3_RS16375	COG0583	DNA-binding transcription factor activity
hmeg3_RS16395	COG1122	ATPase activity
hmeg3_RS16405	COG1268	BioY protein
hmeg3_RS16410	COG0318	PFAM AMP-dependent synthetase and ligase
hmeg3_RS16415	COG0183	Belongs to the thiolase family
hmeg3_RS16455	COG0071	Belongs to the small heat shock protein (HSP20) family
hmeg3_RS16460	COG0583	DNA-binding transcription factor activity
hmeg3_RS16465	COG1942	4-Oxalocrotonate Tautomerase
hmeg3_RS16475	COG3706	GGDEF domain
hmeg3_RS16500	COG2207	Transcriptional regulator
hmeg3_RS16500	COG1609	Transcriptional regulator
hmeg3_RS16505	COG4213	ABC transporter substrate-binding protein
hmeg3_RS16510	COG1129	ABC transporter
hmeg3_RS16515	COG4214	carbohydrate transport
hmeg3_RS16535	COG0129	dihydroxy-acid dehydratase activity
hmeg3_RS16540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
hmeg3_RS16575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
hmeg3_RS16580	COG0501	Belongs to the peptidase M48B family
hmeg3_RS16590	COG5001	Diguanylate cyclase
hmeg3_RS16590	COG4251	negative regulation of phosphorylation
hmeg3_RS16590	COG3706	GGDEF domain
hmeg3_RS16590	COG2203	Gaf domain
hmeg3_RS16610	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
hmeg3_RS16615	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
hmeg3_RS16620	COG0784	Response regulator, receiver
hmeg3_RS16620	COG0835	chemotaxis
hmeg3_RS16645	COG0322	excinuclease ABC activity
hmeg3_RS16650	COG1472	Belongs to the glycosyl hydrolase 3 family
hmeg3_RS16655	COG0736	holo-[acyl-carrier-protein] synthase activity
hmeg3_RS16660	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
hmeg3_RS16665	COG3135	benzoate transporter
hmeg3_RS16675	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
hmeg3_RS16680	COG0571	ribonuclease III activity
hmeg3_RS16685	COG0681	Belongs to the peptidase S26 family
hmeg3_RS16690	COG0481	GTPase activity
hmeg3_RS16700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
hmeg3_RS16725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
hmeg3_RS16730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
hmeg3_RS16745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
hmeg3_RS16750	COG0416	fatty acid biosynthetic process
hmeg3_RS16755	COG0333	Belongs to the bacterial ribosomal protein bL32 family
hmeg3_RS16765	COG0424	maF-like protein
hmeg3_RS16780	COG0517	IMP dehydrogenase activity
hmeg3_RS16780	COG1125	glycine betaine transport
hmeg3_RS16785	COG1846	Transcriptional regulator
hmeg3_RS16800	COG3300	MHYT domain
hmeg3_RS16800	COG5001	Diguanylate cyclase
hmeg3_RS16805	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
hmeg3_RS16815	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
hmeg3_RS16825	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
hmeg3_RS16830	COG1674	ftsk spoiiie
hmeg3_RS16835	COG0492	ferredoxin-NADP+ reductase activity
hmeg3_RS16845	COG2840	Smr protein MutS2
hmeg3_RS16855	COG0667	Aldo Keto reductase
hmeg3_RS16875	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
hmeg3_RS16875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
hmeg3_RS16885	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
hmeg3_RS16895	COG2959	enzyme of heme biosynthesis
hmeg3_RS16905	COG0181	hydroxymethylbilane synthase activity
hmeg3_RS16910	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
hmeg3_RS16935	COG0165	Argininosuccinate lyase
hmeg3_RS16965	COG0415	Belongs to the DNA photolyase family
hmeg3_RS16975	COG2207	Transcriptional regulator
hmeg3_RS16980	COG2986	histidine ammonia-lyase
hmeg3_RS16990	COG0583	DNA-binding transcription factor activity
hmeg3_RS16995	COG2233	PERMEase
hmeg3_RS17010	COG0840	transmembrane signaling receptor activity
hmeg3_RS17035	COG0469	pyruvate kinase activity
hmeg3_RS17045	COG2084	Dehydrogenase
hmeg3_RS17050	COG3622	Belongs to the hyi family
hmeg3_RS17055	COG3960	tartronate-semialdehyde synthase activity
hmeg3_RS17060	COG0583	DNA-binding transcription factor activity
hmeg3_RS17070	COG2252	PERMEase
hmeg3_RS17080	COG1529	Aldehyde oxidase and xanthine dehydrogenase
hmeg3_RS17090	COG0402	S-adenosylhomocysteine deaminase activity
hmeg3_RS17100	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
hmeg3_RS17115	COG2850	peptidyl-arginine hydroxylation
hmeg3_RS17130	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
hmeg3_RS17135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
hmeg3_RS17140	COG0180	Tryptophanyl-tRNA synthetase
hmeg3_RS17145	COG1994	Peptidase M50
hmeg3_RS17150	COG0009	L-threonylcarbamoyladenylate synthase
hmeg3_RS17155	COG0501	Belongs to the peptidase M48B family
hmeg3_RS17160	COG0613	PHP domain protein
hmeg3_RS17165	COG0596	Alpha beta hydrolase
hmeg3_RS17190	COG1286	toxin biosynthetic process
hmeg3_RS17200	COG0285	dihydrofolate synthase activity
hmeg3_RS17205	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
hmeg3_RS17210	COG0159	tryptophan synthase activity
hmeg3_RS17215	COG0133	tryptophan synthase activity
hmeg3_RS17220	COG0135	phosphoribosylanthranilate isomerase activity
hmeg3_RS17225	COG0101	tRNA pseudouridine synthase activity
hmeg3_RS17240	COG0473	3-isopropylmalate dehydrogenase activity
hmeg3_RS17245	COG0066	3-isopropylmalate dehydratase activity
hmeg3_RS17260	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
hmeg3_RS17270	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
hmeg3_RS17290	COG1295	ribonuclease BN
hmeg3_RS17305	COG0277	FAD linked oxidase domain protein
hmeg3_RS17315	COG0840	transmembrane signaling receptor activity
hmeg3_RS17335	COG1178	ABC-type Fe3 transport system permease component
hmeg3_RS17340	COG3842	ATPase activity
hmeg3_RS17345	COG1840	ABC-type Fe3 transport system, periplasmic component
hmeg3_RS17360	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
hmeg3_RS17365	COG1116	anion transmembrane transporter activity
hmeg3_RS17370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
hmeg3_RS17375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
hmeg3_RS17375	COG1116	anion transmembrane transporter activity
hmeg3_RS17400	COG2186	Transcriptional regulator
hmeg3_RS17405	COG0534	Mate efflux family protein
hmeg3_RS17410	COG0667	Aldo Keto reductase
hmeg3_RS17415	COG0025	NhaP-type Na H and K H
hmeg3_RS17435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
hmeg3_RS17445	COG2358	TRAP transporter, solute receptor (TAXI family
hmeg3_RS17465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
hmeg3_RS17470	COG0791	NLP P60 protein
hmeg3_RS17480	COG2186	Transcriptional regulator
hmeg3_RS17500	COG3181	Tripartite tricarboxylate transporter family receptor
hmeg3_RS17510	COG0129	dihydroxy-acid dehydratase activity
hmeg3_RS17520	COG3842	ATPase activity
hmeg3_RS17535	COG3833	ABC-type maltose transport systems, permease component
hmeg3_RS17555	COG0667	Aldo Keto reductase
hmeg3_RS17560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
hmeg3_RS17565	COG0508	dehydrogenase complex catalyzes the overall conversion of
hmeg3_RS17570	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
hmeg3_RS17580	COG0765	amino acid transport
hmeg3_RS17590	COG2918	glutathione biosynthetic process
hmeg3_RS17595	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
hmeg3_RS17615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
hmeg3_RS17625	COG3706	GGDEF domain
hmeg3_RS17630	COG0252	asparaginase activity
hmeg3_RS17635	COG0586	Pfam SNARE associated Golgi protein
hmeg3_RS17670	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS17675	COG1250	3-hydroxyacyl-CoA dehydrogenase
hmeg3_RS17680	COG3246	L-lysine catabolic process to acetate
hmeg3_RS17700	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
hmeg3_RS17720	COG3416	Protein conserved in bacteria
hmeg3_RS17720	COG2943	transferase activity, transferring hexosyl groups
hmeg3_RS17725	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
hmeg3_RS17730	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
hmeg3_RS17760	COG0717	Belongs to the dCTP deaminase family
hmeg3_RS17765	COG1643	Atp-dependent helicase
hmeg3_RS17775	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
hmeg3_RS17775	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
hmeg3_RS17780	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
hmeg3_RS17785	COG0612	Peptidase, M16
hmeg3_RS17790	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
hmeg3_RS17795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
hmeg3_RS17795	COG4651	solute:proton antiporter activity
hmeg3_RS17805	COG1522	sequence-specific DNA binding
hmeg3_RS17815	COG4654	Cytochrome c, class I
hmeg3_RS17820	COG0129	dihydroxy-acid dehydratase activity
hmeg3_RS17825	COG0583	DNA-binding transcription factor activity
hmeg3_RS17830	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
hmeg3_RS17835	COG0785	Cytochrome C biogenesis protein
hmeg3_RS17845	COG0800	Aldolase
hmeg3_RS17855	COG0166	Belongs to the GPI family
hmeg3_RS17860	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
hmeg3_RS17865	COG1737	Transcriptional regulator
hmeg3_RS17885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
hmeg3_RS17895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
hmeg3_RS17900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
hmeg3_RS17905	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
hmeg3_RS17915	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
hmeg3_RS17920	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
hmeg3_RS17925	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
hmeg3_RS17925	COG0662	Cupin 2, conserved barrel domain protein
hmeg3_RS17930	COG3706	GGDEF domain
hmeg3_RS17940	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
hmeg3_RS17950	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
hmeg3_RS17960	COG0776	regulation of translation
hmeg3_RS17970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
hmeg3_RS17975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
hmeg3_RS17980	COG0287	Prephenate dehydrogenase
hmeg3_RS17985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
hmeg3_RS17995	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
hmeg3_RS18015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
hmeg3_RS18020	COG0546	phosphoglycolate phosphatase activity
hmeg3_RS18040	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
hmeg3_RS18075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
hmeg3_RS18080	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
hmeg3_RS18085	COG4221	oxidoreductase activity
hmeg3_RS18090	COG0824	Thioesterase
hmeg3_RS18110	COG0823	Involved in the tonB-independent uptake of proteins
hmeg3_RS18135	COG2363	Small membrane protein
hmeg3_RS18145	COG1012	belongs to the aldehyde dehydrogenase family
hmeg3_RS18155	COG0583	DNA-binding transcription factor activity
hmeg3_RS18165	COG1116	anion transmembrane transporter activity
hmeg3_RS18170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
hmeg3_RS18175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
hmeg3_RS18185	COG3707	response regulator
hmeg3_RS18225	COG2201	protein-glutamate methylesterase activity
hmeg3_RS18245	COG3237	CsbD-like
hmeg3_RS18250	COG2193	ferroxidase activity
hmeg3_RS18295	COG0559	Belongs to the binding-protein-dependent transport system permease family
hmeg3_RS18300	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
hmeg3_RS18305	COG1047	Peptidyl-prolyl cis-trans
hmeg3_RS18310	COG2003	Belongs to the UPF0758 family
hmeg3_RS18315	COG0227	Belongs to the bacterial ribosomal protein bL28 family
hmeg3_RS18320	COG0267	Belongs to the bacterial ribosomal protein bL33 family
hmeg3_RS18340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
hmeg3_RS18345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
hmeg3_RS18345	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
hmeg3_RS18350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
hmeg3_RS18375	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
hmeg3_RS18380	COG0563	adenylate kinase activity
hmeg3_RS18385	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
hmeg3_RS18390	COG2835	tetraacyldisaccharide 4'-kinase activity
hmeg3_RS18395	COG1663	tetraacyldisaccharide 4'-kinase activity
hmeg3_RS18400	COG0848	biopolymer transport protein
hmeg3_RS18405	COG0811	peptide transport
hmeg3_RS18410	COG1570	exodeoxyribonuclease VII activity
hmeg3_RS18415	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
hmeg3_RS18425	COG1741	Belongs to the pirin family
hmeg3_RS18430	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
hmeg3_RS18435	COG0583	DNA-binding transcription factor activity
hmeg3_RS18470	COG1335	isochorismatase
hmeg3_RS18475	COG0656	L-ascorbic acid biosynthetic process
hmeg3_RS18480	COG0657	acetylesterase activity
hmeg3_RS18495	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS18500	COG0583	DNA-binding transcription factor activity
hmeg3_RS18505	COG3046	protein related to deoxyribodipyrimidine photolyase
hmeg3_RS18535	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
hmeg3_RS18555	COG2814	Major facilitator Superfamily
hmeg3_RS18570	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
hmeg3_RS18580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
hmeg3_RS18590	COG0747	negative chemotaxis
hmeg3_RS18605	COG0505	Belongs to the CarA family
hmeg3_RS18610	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
hmeg3_RS18615	COG0784	Response regulator, receiver
hmeg3_RS18620	COG4251	negative regulation of phosphorylation
hmeg3_RS18625	COG0427	acetyl-CoA hydrolase
hmeg3_RS18630	COG0583	DNA-binding transcription factor activity
hmeg3_RS18665	COG2982	Protein involved in outer membrane biogenesis
hmeg3_RS18670	COG0625	glutathione transferase activity
hmeg3_RS18700	COG1247	-acetyltransferase
hmeg3_RS18745	COG5001	Diguanylate cyclase
hmeg3_RS18745	COG4251	negative regulation of phosphorylation
hmeg3_RS18745	COG3706	GGDEF domain
hmeg3_RS18745	COG2203	Gaf domain
hmeg3_RS18775	COG0308	aminopeptidase N
hmeg3_RS18790	COG0697	spore germination
hmeg3_RS18795	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
hmeg3_RS18800	COG0433	COG0433 Predicted ATPase
hmeg3_RS18805	COG0217	transcriptional regulatory protein
hmeg3_RS18810	COG0151	Belongs to the GarS family
hmeg3_RS18815	COG0668	transmembrane transport
hmeg3_RS18820	COG0408	coproporphyrinogen oxidase activity
hmeg3_RS18825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
hmeg3_RS18830	COG0799	negative regulation of ribosome biogenesis
hmeg3_RS18835	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
hmeg3_RS18840	COG0424	maF-like protein
hmeg3_RS18845	COG1530	ribonuclease E activity
hmeg3_RS18850	COG3663	DNA glycosylase
hmeg3_RS18855	COG3781	membrane
hmeg3_RS18860	COG1473	amidohydrolase
hmeg3_RS18865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
hmeg3_RS18885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
hmeg3_RS18900	COG1132	(ABC) transporter
hmeg3_RS18910	COG1442	glycosyl transferase family 8
hmeg3_RS18915	COG1442	glycosyl transferase family 8
hmeg3_RS18930	COG1054	Belongs to the UPF0176 family
hmeg3_RS18940	COG0583	DNA-binding transcription factor activity
hmeg3_RS18945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
hmeg3_RS18950	COG0513	Belongs to the DEAD box helicase family
hmeg3_RS18995	COG4214	carbohydrate transport
hmeg3_RS19010	COG1172	Belongs to the binding-protein-dependent transport system permease family
hmeg3_RS19015	COG1172	Belongs to the binding-protein-dependent transport system permease family
hmeg3_RS19020	COG1129	ABC transporter
hmeg3_RS19025	COG1879	ABC-type sugar transport system periplasmic component
hmeg3_RS19035	COG3734	2-keto-3-deoxy-galactonokinase
hmeg3_RS19040	COG0800	Aldolase
hmeg3_RS19045	COG4948	Mandelate Racemase Muconate Lactonizing
hmeg3_RS19050	COG2814	Major facilitator Superfamily
hmeg3_RS19095	COG0395	ABC-type sugar transport system, permease component
hmeg3_RS19100	COG1175	transmembrane transport
hmeg3_RS19110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
hmeg3_RS19135	COG1176	ABC-type spermidine putrescine transport system, permease component I
hmeg3_RS19145	COG3842	ATPase activity
hmeg3_RS19170	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
hmeg3_RS19205	COG2203	Gaf domain
hmeg3_RS19205	COG5001	Diguanylate cyclase
hmeg3_RS19205	COG3706	GGDEF domain
hmeg3_RS19205	COG4251	negative regulation of phosphorylation
hmeg3_RS19235	COG0840	transmembrane signaling receptor activity
hmeg3_RS19240	COG2010	Cytochrome c
hmeg3_RS19240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
hmeg3_RS19245	COG2080	2 iron, 2 sulfur cluster binding
hmeg3_RS19250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
hmeg3_RS19255	COG3473	Maleate cis-trans isomerase
hmeg3_RS19260	COG0596	Alpha beta hydrolase
hmeg3_RS19265	COG2309	aminopeptidase activity
hmeg3_RS19270	COG1335	isochorismatase
hmeg3_RS19275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
hmeg3_RS19275	COG2010	Cytochrome c
hmeg3_RS19280	COG1846	Transcriptional regulator
hmeg3_RS19285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
hmeg3_RS19290	COG3971	2-oxopent-4-enoate hydratase activity
hmeg3_RS19295	COG0154	amidase activity
hmeg3_RS19345	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
hmeg3_RS19350	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
hmeg3_RS19355	COG3384	dioxygenase
hmeg3_RS19370	COG0683	leucine binding
hmeg3_RS19380	COG0583	DNA-binding transcription factor activity
hmeg3_RS19475	COG4974	Belongs to the 'phage' integrase family
hmeg3_RS19485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
hmeg3_RS19500	COG0828	Belongs to the bacterial ribosomal protein bS21 family
hmeg3_RS19505	COG2081	HI0933 family
hmeg3_RS19510	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
hmeg3_RS19520	COG1074	ATP-dependent DNA helicase activity
hmeg3_RS19535	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
hmeg3_RS19540	COG0583	DNA-binding transcription factor activity
hmeg3_RS19555	COG3971	2-oxopent-4-enoate hydratase activity
hmeg3_RS19590	COG1113	amino acid transport
hmeg3_RS19640	COG0254	rRNA binding
hmeg3_RS19650	COG0534	Mate efflux family protein
hmeg3_RS19665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
hmeg3_RS19670	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
hmeg3_RS19675	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
hmeg3_RS19680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
hmeg3_RS19685	COG4974	Belongs to the 'phage' integrase family
hmeg3_RS19690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
hmeg3_RS19735	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
hmeg3_RS19740	COG0802	atpase or kinase
hmeg3_RS19745	COG0860	N-Acetylmuramoyl-L-alanine amidase
hmeg3_RS19750	COG0840	transmembrane signaling receptor activity
hmeg3_RS19755	COG0586	Pfam SNARE associated Golgi protein
hmeg3_RS19760	COG0840	transmembrane signaling receptor activity
hmeg3_RS19765	COG2200	EAL domain
hmeg3_RS19765	COG2199	diguanylate cyclase activity
hmeg3_RS19765	COG2202	Pas domain
hmeg3_RS19775	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
hmeg3_RS19780	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
hmeg3_RS19795	COG1335	isochorismatase
hmeg3_RS19800	COG0583	DNA-binding transcription factor activity
hmeg3_RS19805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
hmeg3_RS19810	COG1702	phosphate starvation-inducible protein PhoH
hmeg3_RS19815	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
hmeg3_RS19825	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
hmeg3_RS19830	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
hmeg3_RS19840	COG4535	Mg2 and Co2 transporter CorC
hmeg3_RS19845	COG0815	Transfers the fatty acyl group on membrane lipoproteins
hmeg3_RS19850	COG0752	glycyl-tRNA synthetase alpha subunit
hmeg3_RS19855	COG0751	glycine-tRNA ligase activity
hmeg3_RS19860	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
hmeg3_RS19875	COG0346	lactoylglutathione lyase activity
hmeg3_RS19885	COG0840	transmembrane signaling receptor activity
hmeg3_RS19895	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
hmeg3_RS19900	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
hmeg3_RS19905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
hmeg3_RS19910	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
hmeg3_RS19920	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
hmeg3_RS19925	COG0006	proline dipeptidase activity
hmeg3_RS19930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
hmeg3_RS19960	COG0482	sulfurtransferase activity
hmeg3_RS20000	COG0625	glutathione transferase activity
hmeg3_RS20010	COG3038	cytochrome b561
hmeg3_RS20020	COG2353	YceI-like domain
hmeg3_RS20025	COG0259	pyridoxamine-phosphate oxidase activity
hmeg3_RS20030	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
hmeg3_RS20035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
hmeg3_RS20040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
hmeg3_RS20045	COG3047	cAMP biosynthetic process
hmeg3_RS20050	COG0009	L-threonylcarbamoyladenylate synthase
hmeg3_RS20055	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
hmeg3_RS20060	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
hmeg3_RS20070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
hmeg3_RS20080	COG0469	pyruvate kinase activity
hmeg3_RS20085	COG0126	phosphoglycerate kinase activity
hmeg3_RS20115	COG0429	hydrolase of the alpha beta-hydrolase fold
hmeg3_RS20130	COG0315	cyclic pyranopterin monophosphate synthase activity
hmeg3_RS20135	COG4969	Belongs to the N-Me-Phe pilin family
hmeg3_RS20140	COG0861	Integral membrane protein TerC family
hmeg3_RS20145	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
hmeg3_RS20150	COG0045	succinate-CoA ligase (ADP-forming) activity
hmeg3_RS20160	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
hmeg3_RS20180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
hmeg3_RS20190	COG1764	response to oxidative stress
hmeg3_RS20210	COG0642	Histidine kinase
hmeg3_RS20220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
hmeg3_RS20225	COG0840	transmembrane signaling receptor activity
hmeg3_RS20230	COG1305	Transglutaminase-like
hmeg3_RS20260	COG2308	Evidence 4 Homologs of previously reported genes of
hmeg3_RS20280	COG0628	permease
hmeg3_RS20285	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
hmeg3_RS20295	COG0617	tRNA 3'-terminal CCA addition
hmeg3_RS20305	COG2203	Gaf domain
hmeg3_RS20305	COG3706	GGDEF domain
hmeg3_RS20305	COG4251	negative regulation of phosphorylation
hmeg3_RS20305	COG5001	Diguanylate cyclase
hmeg3_RS20310	COG2201	protein-glutamate methylesterase activity
hmeg3_RS20315	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
hmeg3_RS20320	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
hmeg3_RS20325	COG0835	chemotaxis
hmeg3_RS20330	COG0840	transmembrane signaling receptor activity
hmeg3_RS20335	COG0840	transmembrane signaling receptor activity
hmeg3_RS20350	COG0745	RESPONSE REGULATOR receiver
hmeg3_RS20365	COG1428	Deoxynucleoside kinase
hmeg3_RS20370	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
hmeg3_RS20375	COG0288	reversible hydration of carbon dioxide
hmeg3_RS20380	COG0484	heat shock protein binding
hmeg3_RS20385	COG0443	Heat shock 70 kDa protein
hmeg3_RS20390	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
hmeg3_RS20395	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
hmeg3_RS20400	COG0497	DNA recombination
hmeg3_RS20405	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
hmeg3_RS20415	COG1420	regulation of RNA biosynthetic process
hmeg3_RS20420	COG0735	belongs to the Fur family
hmeg3_RS20425	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
hmeg3_RS20430	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
hmeg3_RS20450	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
hmeg3_RS20455	COG3842	ATPase activity
hmeg3_RS20460	COG1177	transmembrane transport
hmeg3_RS20475	COG1609	Transcriptional regulator
hmeg3_RS20480	COG0495	leucyl-tRNA aminoacylation
hmeg3_RS20495	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
hmeg3_RS20500	COG1981	membrane
hmeg3_RS20520	COG3384	dioxygenase
hmeg3_RS20525	COG0583	DNA-binding transcription factor activity
hmeg3_RS20535	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS20540	COG2271	Major facilitator Superfamily
hmeg3_RS20545	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS20550	COG1414	Transcriptional regulator
hmeg3_RS20565	COG0004	ammonium transporteR
hmeg3_RS20570	COG1073	alpha beta
hmeg3_RS20590	COG0656	L-ascorbic acid biosynthetic process
hmeg3_RS20595	COG0583	DNA-binding transcription factor activity
hmeg3_RS20630	COG0583	DNA-binding transcription factor activity
hmeg3_RS20660	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
hmeg3_RS20665	COG2207	Transcriptional regulator
hmeg3_RS20685	COG0165	Argininosuccinate lyase
hmeg3_RS20695	COG0583	DNA-binding transcription factor activity
hmeg3_RS20700	COG2203	Gaf domain
hmeg3_RS20700	COG4251	negative regulation of phosphorylation
hmeg3_RS20700	COG5001	Diguanylate cyclase
hmeg3_RS20700	COG3706	GGDEF domain
hmeg3_RS20705	COG0500	methyltransferase
hmeg3_RS20720	COG2186	Transcriptional regulator
hmeg3_RS20730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
hmeg3_RS20735	COG0590	tRNA wobble adenosine to inosine editing
hmeg3_RS20735	COG0037	tRNA processing
hmeg3_RS20750	COG3706	GGDEF domain
hmeg3_RS20755	COG0840	transmembrane signaling receptor activity
hmeg3_RS20780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
hmeg3_RS20790	COG0604	alcohol dehydrogenase
hmeg3_RS20800	COG0625	glutathione transferase activity
hmeg3_RS20810	COG2860	membrane
hmeg3_RS20820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
hmeg3_RS20830	COG3971	2-oxopent-4-enoate hydratase activity
hmeg3_RS20835	COG3447	MASE1 domain protein
hmeg3_RS20835	COG5001	Diguanylate cyclase
hmeg3_RS20835	COG5002	protein histidine kinase activity
hmeg3_RS20860	COG0220	tRNA (guanine-N7-)-methyltransferase activity
hmeg3_RS20865	COG0840	transmembrane signaling receptor activity
hmeg3_RS20870	COG0514	ATP-dependent DNA helicase (RecQ)
hmeg3_RS20875	COG1968	undecaprenyl-diphosphatase activity
hmeg3_RS20880	COG1968	undecaprenyl-diphosphatase activity
hmeg3_RS20900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
hmeg3_RS20910	COG0066	3-isopropylmalate dehydratase activity
hmeg3_RS20915	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
hmeg3_RS20925	COG2030	dehydratase
hmeg3_RS20930	COG1960	acyl-CoA dehydrogenase activity
hmeg3_RS20935	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS20960	COG1024	Enoyl-CoA hydratase
hmeg3_RS20970	COG0183	Belongs to the thiolase family
hmeg3_RS21010	COG1464	Belongs to the NlpA lipoprotein family
hmeg3_RS21015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
hmeg3_RS21020	COG2011	ABC-type metal ion transport system permease component
hmeg3_RS21040	COG3618	amidohydrolase
hmeg3_RS21055	COG1172	Belongs to the binding-protein-dependent transport system permease family
hmeg3_RS21060	COG1129	ABC transporter
hmeg3_RS21070	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS21075	COG4948	Mandelate Racemase Muconate Lactonizing
hmeg3_RS21105	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
hmeg3_RS21120	COG1309	transcriptional regulator
hmeg3_RS21125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
hmeg3_RS21130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
hmeg3_RS21180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
hmeg3_RS21190	COG1442	glycosyl transferase family 8
hmeg3_RS21200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
hmeg3_RS21230	COG1132	(ABC) transporter
hmeg3_RS21270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
hmeg3_RS21285	COG2089	acid synthase
hmeg3_RS21295	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS21305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
hmeg3_RS21310	COG1086	Polysaccharide biosynthesis protein
hmeg3_RS21320	COG4310	Domain of unknown function (DUF2172)
hmeg3_RS21345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
hmeg3_RS21350	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
hmeg3_RS21360	COG1215	transferase activity, transferring glycosyl groups
hmeg3_RS21365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
hmeg3_RS21380	COG0540	Belongs to the ATCase OTCase family
hmeg3_RS21385	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
hmeg3_RS21395	COG1678	Uncharacterized ACR, COG1678
hmeg3_RS21405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
hmeg3_RS21420	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
hmeg3_RS21435	COG0412	Dienelactone hydrolase
hmeg3_RS21440	COG0840	transmembrane signaling receptor activity
hmeg3_RS21460	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
hmeg3_RS21470	COG0840	transmembrane signaling receptor activity
hmeg3_RS21475	COG1070	Carbohydrate kinase
hmeg3_RS21480	COG0246	Mannitol dehydrogenase
hmeg3_RS21485	COG3842	ATPase activity
hmeg3_RS21490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
hmeg3_RS21500	COG1175	transmembrane transport
hmeg3_RS21520	COG0210	DNA helicase
hmeg3_RS21530	COG0783	Belongs to the Dps family
hmeg3_RS21535	COG0352	thiamine-phosphate diphosphorylase activity
hmeg3_RS21540	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
hmeg3_RS21540	COG0352	thiamine-phosphate diphosphorylase activity
hmeg3_RS21540	COG0351	phosphomethylpyrimidine kinase
hmeg3_RS21545	COG2022	thiamine diphosphate biosynthetic process
hmeg3_RS21555	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
hmeg3_RS21560	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
hmeg3_RS21565	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
hmeg3_RS21570	COG3958	Transketolase
hmeg3_RS21575	COG3959	Transketolase, thiamine diphosphate binding domain
hmeg3_RS21580	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS21585	COG0583	DNA-binding transcription factor activity
hmeg3_RS21595	COG0525	valine-tRNA ligase activity
hmeg3_RS21615	COG1671	Belongs to the UPF0178 family
hmeg3_RS21620	COG3971	2-oxopent-4-enoate hydratase activity
hmeg3_RS21625	COG2255	four-way junction helicase activity
hmeg3_RS21630	COG0632	four-way junction helicase activity
hmeg3_RS21635	COG2354	Protein conserved in bacteria
hmeg3_RS21640	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
hmeg3_RS21645	COG0138	bifunctional purine biosynthesis protein purh
hmeg3_RS21650	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
hmeg3_RS21665	COG1881	PFAM PEBP family protein
hmeg3_RS21670	COG1490	D-aminoacyl-tRNA deacylase activity
hmeg3_RS21675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
hmeg3_RS21680	COG0739	heme binding
hmeg3_RS21685	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
hmeg3_RS21700	COG0598	Magnesium transport protein CorA
hmeg3_RS21705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
hmeg3_RS21710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
hmeg3_RS21720	COG0557	exoribonuclease II activity
hmeg3_RS21725	COG3161	chorismate lyase activity
hmeg3_RS21730	COG3150	esterase
hmeg3_RS21735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
hmeg3_RS21745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
hmeg3_RS21750	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
hmeg3_RS21755	COG0511	ligase activity, forming carbon-carbon bonds
hmeg3_RS21760	COG0439	Biotin carboxylase
hmeg3_RS21765	COG2264	protein methyltransferase activity
hmeg3_RS21775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
hmeg3_RS21820	COG1116	anion transmembrane transporter activity
hmeg3_RS21825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
hmeg3_RS21830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
hmeg3_RS21835	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
hmeg3_RS21850	COG0741	lytic transglycosylase activity
hmeg3_RS21855	COG0442	prolyl-tRNA aminoacylation
hmeg3_RS21860	COG0494	nUDIX hydrolase
hmeg3_RS21870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
hmeg3_RS21875	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
hmeg3_RS21880	COG0211	Belongs to the bacterial ribosomal protein bL27 family
hmeg3_RS21885	COG0261	This protein binds to 23S rRNA in the presence of protein L20
hmeg3_RS21890	COG0142	geranyltranstransferase activity
hmeg3_RS21900	COG4536	flavin adenine dinucleotide binding
hmeg3_RS21910	COG1459	type II secretion system
hmeg3_RS21915	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
hmeg3_RS21925	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
hmeg3_RS21930	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
hmeg3_RS21955	COG2076	Multidrug Resistance protein
hmeg3_RS21960	COG0653	protein targeting
hmeg3_RS21965	COG0739	heme binding
hmeg3_RS21975	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
hmeg3_RS21980	COG0678	peroxiredoxin activity
hmeg3_RS21985	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
hmeg3_RS21995	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
hmeg3_RS22000	COG1181	Belongs to the D-alanine--D-alanine ligase family
hmeg3_RS22005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
hmeg3_RS22010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
hmeg3_RS22020	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
hmeg3_RS22025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
hmeg3_RS22030	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
hmeg3_RS22035	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
hmeg3_RS22045	COG3116	cell division
hmeg3_RS22050	COG0275	rRNA processing
hmeg3_RS22055	COG2001	Belongs to the MraZ family
hmeg3_RS22075	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
hmeg3_RS22085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
hmeg3_RS22095	COG1309	transcriptional regulator
hmeg3_RS22100	COG1024	Enoyl-CoA hydratase
hmeg3_RS22120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
hmeg3_RS22135	COG0667	Aldo Keto reductase
hmeg3_RS22140	COG2207	Transcriptional regulator
hmeg3_RS22145	COG0583	DNA-binding transcription factor activity
hmeg3_RS22155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
hmeg3_RS22185	COG0659	secondary active sulfate transmembrane transporter activity
hmeg3_RS22190	COG0840	transmembrane signaling receptor activity
hmeg3_RS22205	COG0583	DNA-binding transcription factor activity
hmeg3_RS22220	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
hmeg3_RS22225	COG1234	tRNA 3'-trailer cleavage
hmeg3_RS22240	COG2831	hemolysin activation secretion protein
hmeg3_RS22250	COG0443	Heat shock 70 kDa protein
hmeg3_RS22255	COG0642	Histidine kinase
hmeg3_RS22265	COG3713	MltA-interacting MipA family protein
hmeg3_RS22270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
hmeg3_RS22285	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS22290	COG2134	cdp-diacylglycerol pyrophosphatase
hmeg3_RS22295	COG0656	L-ascorbic acid biosynthetic process
hmeg3_RS22340	COG1024	Enoyl-CoA hydratase
hmeg3_RS22345	COG0183	Belongs to the thiolase family
hmeg3_RS22350	COG1250	3-hydroxyacyl-CoA dehydrogenase
hmeg3_RS22350	COG1024	Enoyl-CoA hydratase
hmeg3_RS22355	COG1960	acyl-CoA dehydrogenase activity
hmeg3_RS22370	COG0183	Belongs to the thiolase family
hmeg3_RS22375	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
hmeg3_RS22385	COG3568	Endonuclease Exonuclease Phosphatase
hmeg3_RS22390	COG0494	nUDIX hydrolase
hmeg3_RS22400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
hmeg3_RS22410	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
hmeg3_RS22425	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
hmeg3_RS22435	COG1877	trehalose-phosphatase activity
hmeg3_RS22440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
hmeg3_RS22445	COG2094	Belongs to the DNA glycosylase MPG family
hmeg3_RS22460	COG1965	Belongs to the frataxin family
hmeg3_RS22470	COG2165	general secretion pathway protein
hmeg3_RS22480	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
hmeg3_RS22485	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
hmeg3_RS22490	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
hmeg3_RS22490	COG0506	proline dehydrogenase activity
hmeg3_RS22490	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
hmeg3_RS22515	COG0559	Belongs to the binding-protein-dependent transport system permease family
hmeg3_RS22520	COG2423	ornithine cyclodeaminase activity
hmeg3_RS22545	COG4206	TonB-dependent receptor
hmeg3_RS22560	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
hmeg3_RS22570	COG0793	Belongs to the peptidase S41A family
hmeg3_RS22575	COG4942	peptidase
hmeg3_RS22585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
hmeg3_RS22585	COG0425	Belongs to the sulfur carrier protein TusA family
hmeg3_RS22595	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
hmeg3_RS22615	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
hmeg3_RS22625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
hmeg3_RS22630	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
hmeg3_RS22635	COG1333	cytochrome c biogenesis protein
hmeg3_RS22645	COG0218	Necessary for normal cell division and for the maintenance of normal septation
hmeg3_RS22655	COG4521	taurine ABC transporter
hmeg3_RS22660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
hmeg3_RS22665	COG1116	anion transmembrane transporter activity
hmeg3_RS22670	COG1794	racemase activity, acting on amino acids and derivatives
hmeg3_RS22685	COG1012	belongs to the aldehyde dehydrogenase family
hmeg3_RS22700	COG0450	alkyl hydroperoxide reductase
hmeg3_RS22705	COG4232	protein-disulfide reductase activity
hmeg3_RS22710	COG1324	tolerance protein
hmeg3_RS22725	COG0203	ribosomal protein L17
hmeg3_RS22730	COG0202	RNA polymerase activity
hmeg3_RS22735	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
hmeg3_RS22740	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
hmeg3_RS22745	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
hmeg3_RS22750	COG0257	Belongs to the bacterial ribosomal protein bL36 family
hmeg3_RS22755	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
hmeg3_RS22760	COG0201	protein transport
hmeg3_RS22765	COG0200	Binds to the 23S rRNA
hmeg3_RS22770	COG1841	ribosomal large subunit assembly
hmeg3_RS22775	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
hmeg3_RS22780	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
hmeg3_RS22785	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
hmeg3_RS22790	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
hmeg3_RS22795	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
hmeg3_RS22800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
hmeg3_RS22805	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
hmeg3_RS22810	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
hmeg3_RS22820	COG0255	Belongs to the universal ribosomal protein uL29 family
hmeg3_RS22825	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
hmeg3_RS22830	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
hmeg3_RS22835	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
hmeg3_RS22840	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
hmeg3_RS22845	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
hmeg3_RS22850	COG0089	rRNA binding
hmeg3_RS22855	COG0088	Forms part of the polypeptide exit tunnel
hmeg3_RS22860	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
hmeg3_RS22865	COG0051	transcription antitermination factor activity, RNA binding
hmeg3_RS22870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
hmeg3_RS22875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
hmeg3_RS22880	COG0049	tRNA binding
hmeg3_RS22885	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
hmeg3_RS22890	COG3720	iron ion transport
hmeg3_RS22895	COG4771	TonB-dependent receptor
hmeg3_RS22900	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
hmeg3_RS22905	COG0085	RNA polymerase activity
hmeg3_RS22910	COG0222	ribosome binding
hmeg3_RS22915	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
hmeg3_RS22920	COG0081	regulation of translation
hmeg3_RS22925	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
hmeg3_RS22945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
hmeg3_RS22965	COG2814	Major facilitator Superfamily
hmeg3_RS22970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
hmeg3_RS22975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
hmeg3_RS22980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
hmeg3_RS22985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
hmeg3_RS22995	COG0189	ligase activity
hmeg3_RS23005	COG0004	ammonium transporteR
hmeg3_RS23025	COG0606	chelatase, subunit chli
hmeg3_RS23030	COG1297	OPT oligopeptide transporter protein
hmeg3_RS23040	COG0697	spore germination
hmeg3_RS23055	COG2814	Major facilitator Superfamily
hmeg3_RS23060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
hmeg3_RS23060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
hmeg3_RS23070	COG5000	phosphorelay sensor kinase activity
hmeg3_RS23075	COG2204	response regulator
hmeg3_RS23095	COG3158	transport of potassium into the cell
hmeg3_RS23120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
hmeg3_RS23130	COG4172	Belongs to the ABC transporter superfamily
hmeg3_RS23145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
hmeg3_RS23150	COG0601	transmembrane transport
hmeg3_RS23155	COG0747	negative chemotaxis
hmeg3_RS23175	COG3128	pkhd-type hydroxylase
hmeg3_RS23180	COG4774	siderophore transport
hmeg3_RS23200	COG0583	DNA-binding transcription factor activity
hmeg3_RS23210	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS23220	COG0583	DNA-binding transcription factor activity
hmeg3_RS23230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
hmeg3_RS23235	COG0765	amino acid transport
hmeg3_RS23240	COG1126	abc transporter atp-binding protein
hmeg3_RS23245	COG0010	Belongs to the arginase family
hmeg3_RS23255	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
hmeg3_RS23275	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
hmeg3_RS23275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
hmeg3_RS23280	COG0583	DNA-binding transcription factor activity
hmeg3_RS23305	COG0523	cobalamin synthesis protein
hmeg3_RS23310	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
hmeg3_RS23315	COG2814	Major facilitator Superfamily
hmeg3_RS23345	COG4521	taurine ABC transporter
hmeg3_RS23350	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
hmeg3_RS23355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
hmeg3_RS23360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
hmeg3_RS23365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
hmeg3_RS23395	COG0583	DNA-binding transcription factor activity
hmeg3_RS23400	COG1902	pentaerythritol trinitrate reductase activity
hmeg3_RS23405	COG0667	Aldo Keto reductase
hmeg3_RS23415	COG0235	Class ii aldolase
hmeg3_RS23420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
hmeg3_RS23435	COG0165	Argininosuccinate lyase
hmeg3_RS23455	COG2197	response regulator
hmeg3_RS23485	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
hmeg3_RS23490	COG3850	Histidine kinase
hmeg3_RS23490	COG3437	response regulator, receiver
hmeg3_RS23490	COG2205	protein histidine kinase activity
hmeg3_RS23490	COG4999	Histidine kinase
hmeg3_RS23495	COG4999	Histidine kinase
hmeg3_RS23495	COG3850	Histidine kinase
hmeg3_RS23495	COG3437	response regulator, receiver
hmeg3_RS23495	COG2205	protein histidine kinase activity
hmeg3_RS23510	COG0583	DNA-binding transcription factor activity
hmeg3_RS23515	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
hmeg3_RS23520	COG0436	Aminotransferase
hmeg3_RS23525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
hmeg3_RS23535	COG0765	amino acid transport
hmeg3_RS23545	COG2080	2 iron, 2 sulfur cluster binding
hmeg3_RS23550	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
hmeg3_RS23555	COG1529	Aldehyde oxidase and xanthine dehydrogenase
hmeg3_RS23570	COG0697	spore germination
hmeg3_RS23580	COG0583	DNA-binding transcription factor activity
hmeg3_RS23585	COG4943	cyclic-guanylate-specific phosphodiesterase activity
hmeg3_RS23590	COG2814	Major facilitator Superfamily
hmeg3_RS23600	COG0583	DNA-binding transcription factor activity
hmeg3_RS23610	COG1012	belongs to the aldehyde dehydrogenase family
hmeg3_RS23665	COG2205	protein histidine kinase activity
hmeg3_RS23665	COG0784	Response regulator, receiver
hmeg3_RS23670	COG2197	response regulator
hmeg3_RS23685	COG1116	anion transmembrane transporter activity
hmeg3_RS23690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
hmeg3_RS23700	COG0154	amidase activity
hmeg3_RS23780	COG0583	DNA-binding transcription factor activity
hmeg3_RS23815	COG3210	domain, Protein
hmeg3_RS23820	COG2831	hemolysin activation secretion protein
hmeg3_RS23840	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS23860	COG0640	Transcriptional regulator
hmeg3_RS23890	COG1802	Transcriptional regulator
hmeg3_RS23905	COG0583	DNA-binding transcription factor activity
hmeg3_RS23920	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
hmeg3_RS23925	COG4221	oxidoreductase activity
hmeg3_RS23940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
hmeg3_RS23950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
hmeg3_RS23955	COG1283	sodium-dependent phosphate transmembrane transporter activity
hmeg3_RS23965	COG0840	transmembrane signaling receptor activity
hmeg3_RS23975	COG4774	siderophore transport
hmeg3_RS23985	COG1595	DNA-templated transcription, initiation
hmeg3_RS24000	COG1451	nucleotide metabolic process
hmeg3_RS24005	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
hmeg3_RS24040	COG1028	Short-chain dehydrogenase reductase Sdr
hmeg3_RS24045	COG0583	DNA-binding transcription factor activity
hmeg3_RS24075	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
hmeg3_RS24080	COG0321	lipoyl(octanoyl) transferase activity
hmeg3_RS24090	COG0583	DNA-binding transcription factor activity
hmeg3_RS24100	COG2921	Belongs to the UPF0250 family
hmeg3_RS24110	COG4178	(ABC) transporter
hmeg3_RS24115	COG1132	(ABC) transporter
hmeg3_RS24160	COG1192	Involved in chromosome partitioning
hmeg3_RS24170	COG3040	lipid binding
hmeg3_RS24175	COG0357	Ribosomal RNA small subunit methyltransferase G
hmeg3_RS24180	COG0445	tRNA wobble uridine modification
hmeg3_RS24190	COG0210	DNA helicase
hmeg3_RS24195	COG1172	Belongs to the binding-protein-dependent transport system permease family
hmeg3_RS24215	COG0411	ABC transporter
hmeg3_RS24230	COG0583	DNA-binding transcription factor activity
hmeg3_RS24240	COG2982	Protein involved in outer membrane biogenesis
hmeg3_RS24260	COG0121	glutamine amidotransferase
hmeg3_RS24265	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
hmeg3_RS24270	COG0592	DNA-directed DNA polymerase activity
hmeg3_RS24290	COG1403	HNH endonuclease
hmeg3_RS24315	COG4133	protoheme IX ABC transporter activity
hmeg3_RS24335	COG0583	DNA-binding transcription factor activity
hmeg3_RS24375	COG1595	DNA-templated transcription, initiation
hmeg3_RS24385	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
hmeg3_RS24390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
hmeg3_RS24395	COG0840	transmembrane signaling receptor activity
hmeg3_RS24400	COG0583	DNA-binding transcription factor activity
hmeg3_RS24430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
hmeg3_RS24435	COG0444	Belongs to the ABC transporter superfamily
hmeg3_RS24440	COG4608	Belongs to the ABC transporter superfamily
hmeg3_RS24485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
hmeg3_RS24490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
hmeg3_RS24500	COG0765	amino acid transport
hmeg3_RS24505	COG0765	amino acid transport
hmeg3_RS24515	COG1414	Transcriptional regulator
hmeg3_RS24520	COG3842	ATPase activity
hmeg3_RS24525	COG1176	ABC-type spermidine putrescine transport system, permease component I
hmeg3_RS24530	COG1177	transmembrane transport
hmeg3_RS24535	COG3383	formate dehydrogenase (NAD+) activity