locus-tag	class	description
HVS_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HVS_RS00010	COG0592	DNA-directed DNA polymerase activity
HVS_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HVS_RS00030	COG0187	DNA topoisomerase II activity
HVS_RS00035	COG1192	Involved in chromosome partitioning
HVS_RS00040	COG1475	DNA binding
HVS_RS00055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HVS_RS00070	COG1183	phosphatidylcholine synthase activity
HVS_RS00080	COG2373	Large extracellular alpha-helical protein
HVS_RS00090	COG2720	vancomycin resistance protein
HVS_RS00110	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HVS_RS00120	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVS_RS00125	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVS_RS00155	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HVS_RS00175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HVS_RS00180	COG1802	Transcriptional regulator
HVS_RS00195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HVS_RS00215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HVS_RS00225	COG2959	enzyme of heme biosynthesis
HVS_RS00235	COG1484	DNA-dependent DNA replication
HVS_RS00250	COG1653	transport
HVS_RS00255	COG1175	transmembrane transport
HVS_RS00260	COG0395	ABC-type sugar transport system, permease component
HVS_RS00265	COG3275	phosphorelay sensor kinase activity
HVS_RS00270	COG3279	Response regulator of the LytR AlgR family
HVS_RS00305	COG1595	DNA-templated transcription, initiation
HVS_RS00310	COG3693	PFAM glycoside hydrolase, family 10
HVS_RS00315	COG1361	Conserved repeat domain
HVS_RS00345	COG0574	Belongs to the PEP-utilizing enzyme family
HVS_RS00345	COG3848	Pyruvate phosphate dikinase
HVS_RS00355	COG0688	phosphatidylethanolamine metabolic process
HVS_RS00365	COG3848	Pyruvate phosphate dikinase
HVS_RS00365	COG0574	Belongs to the PEP-utilizing enzyme family
HVS_RS00375	COG0840	transmembrane signaling receptor activity
HVS_RS00400	COG0693	protein deglycase activity
HVS_RS00405	COG0667	Aldo Keto reductase
HVS_RS00410	COG0546	phosphoglycolate phosphatase activity
HVS_RS00435	COG4942	peptidase
HVS_RS00435	COG1418	mRNA catabolic process
HVS_RS00455	COG2208	phosphoserine phosphatase activity
HVS_RS00465	COG3693	PFAM glycoside hydrolase, family 10
HVS_RS00465	COG3507	Belongs to the glycosyl hydrolase 43 family
HVS_RS00465	COG2382	esterase
HVS_RS00470	COG3507	Belongs to the glycosyl hydrolase 43 family
HVS_RS00470	COG2382	esterase
HVS_RS00470	COG3693	PFAM glycoside hydrolase, family 10
HVS_RS00490	COG4786	Flagellar basal body rod
HVS_RS00505	COG0840	transmembrane signaling receptor activity
HVS_RS00510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HVS_RS00515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HVS_RS00520	COG2088	sporulation resulting in formation of a cellular spore
HVS_RS00525	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HVS_RS00535	COG0193	aminoacyl-tRNA hydrolase activity
HVS_RS00540	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HVS_RS00545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVS_RS00550	COG2002	toxin-antitoxin pair type II binding
HVS_RS00555	COG3956	TIGRFAM MazG family protein
HVS_RS00560	COG0776	regulation of translation
HVS_RS00565	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HVS_RS00585	COG1098	S1 RNA binding domain
HVS_RS00590	COG2897	thiosulfate sulfurtransferase activity
HVS_RS00600	COG0668	transmembrane transport
HVS_RS00605	COG3942	CHAP domain
HVS_RS00605	COG1388	LysM domain
HVS_RS00630	COG1773	rubredoxin
HVS_RS00635	COG1366	Belongs to the anti-sigma-factor antagonist family
HVS_RS00655	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HVS_RS00660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HVS_RS00665	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HVS_RS00750	COG3464	Transposase
HVS_RS00800	COG3464	Transposase
HVS_RS00860	COG3266	domain, Protein
HVS_RS00860	COG2911	Protein conserved in bacteria
HVS_RS00860	COG1361	Conserved repeat domain
HVS_RS01040	COG3328	transposase activity
HVS_RS01055	COG3464	Transposase
HVS_RS01060	COG2801	Transposase and inactivated derivatives
HVS_RS01070	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVS_RS01085	COG2801	Transposase and inactivated derivatives
HVS_RS01120	COG1361	Conserved repeat domain
HVS_RS01135	COG0590	tRNA wobble adenosine to inosine editing
HVS_RS01140	COG0028	Belongs to the TPP enzyme family
HVS_RS01145	COG0440	acetolactate synthase activity
HVS_RS01150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HVS_RS01155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HVS_RS01160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HVS_RS01165	COG1191	sigma factor activity
HVS_RS01170	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HVS_RS01175	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVS_RS01190	COG0629	single-stranded DNA binding
HVS_RS01195	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HVS_RS01205	COG1295	ribonuclease BN
HVS_RS01210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVS_RS01235	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HVS_RS01240	COG0254	rRNA binding
HVS_RS01250	COG1394	ATPase activity, coupled to movement of substances
HVS_RS01255	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HVS_RS01260	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HVS_RS01270	COG1527	subunit (C
HVS_RS01275	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HVS_RS01280	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HVS_RS01285	COG1269	ATP hydrolysis coupled proton transport
HVS_RS01295	COG1605	Chorismate mutase
HVS_RS01295	COG0077	Prephenate dehydratase
HVS_RS01305	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HVS_RS01310	COG0359	binds to the 23S rRNA
HVS_RS01315	COG0305	Participates in initiation and elongation during chromosome replication
HVS_RS01320	COG0037	tRNA processing
HVS_RS01325	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HVS_RS01330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HVS_RS01335	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HVS_RS01355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HVS_RS01360	COG1040	competence protein
HVS_RS01380	COG1256	bacterial-type flagellum assembly
HVS_RS01380	COG4786	Flagellar basal body rod
HVS_RS01390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HVS_RS01400	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HVS_RS01405	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HVS_RS01420	COG2604	Protein of unknown function DUF115
HVS_RS01425	COG1086	Polysaccharide biosynthesis protein
HVS_RS01440	COG2089	acid synthase
HVS_RS01445	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HVS_RS01460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HVS_RS01465	COG1028	Short-chain dehydrogenase reductase Sdr
HVS_RS01470	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HVS_RS01535	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HVS_RS01545	COG0732	type I restriction modification DNA specificity domain
HVS_RS01550	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HVS_RS01570	COG4626	Terminase
HVS_RS01570	COG1802	Transcriptional regulator
HVS_RS01590	COG1164	Oligoendopeptidase f
HVS_RS01605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVS_RS01610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVS_RS01615	COG1121	(ABC) transporter
HVS_RS01620	COG0803	Belongs to the bacterial solute-binding protein 9 family
HVS_RS01625	COG2239	Acts as a magnesium transporter
HVS_RS01630	COG0590	tRNA wobble adenosine to inosine editing
HVS_RS01645	COG2878	Part of a membrane complex involved in electron transport
HVS_RS01645	COG1245	4Fe-4S binding domain
HVS_RS01650	COG4657	Part of a membrane complex involved in electron transport
HVS_RS01655	COG4660	Part of a membrane complex involved in electron transport
HVS_RS01665	COG4658	electron transport chain
HVS_RS01670	COG4656	Part of a membrane complex involved in electron transport
HVS_RS01675	COG2890	protein-(glutamine-N5) methyltransferase activity
HVS_RS01680	COG3872	metal-dependent enzyme
HVS_RS01705	COG3291	Pkd domain containing protein
HVS_RS01730	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVS_RS01735	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HVS_RS01745	COG0018	arginyl-trna synthetase
HVS_RS01765	COG0793	Belongs to the peptidase S41A family
HVS_RS01770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HVS_RS01780	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HVS_RS01785	COG2183	response to ionizing radiation
HVS_RS01815	COG0785	Cytochrome C biogenesis protein
HVS_RS01820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HVS_RS01830	COG0492	ferredoxin-NADP+ reductase activity
HVS_RS01875	COG3547	Transposase (IS116 IS110 IS902 family)
HVS_RS01900	COG1361	Conserved repeat domain
HVS_RS01945	COG3464	Transposase
HVS_RS02130	COG1131	(ABC) transporter
HVS_RS02170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HVS_RS02225	COG2217	Heavy metal translocating P-type atpase
HVS_RS02230	COG2333	competence protein COMEC
HVS_RS02230	COG0658	competence protein
HVS_RS02240	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HVS_RS02255	COG0246	Mannitol dehydrogenase
HVS_RS02260	COG1312	Catalyzes the dehydration of D-mannonate
HVS_RS02265	COG0800	Aldolase
HVS_RS02280	COG2207	Transcriptional regulator
HVS_RS02280	COG4753	response regulator
HVS_RS02285	COG2972	Histidine kinase
HVS_RS02290	COG4753	response regulator
HVS_RS02290	COG2207	Transcriptional regulator
HVS_RS02290	COG4753	response regulator
HVS_RS02290	COG2207	Transcriptional regulator
HVS_RS02300	COG4209	transmembrane transport
HVS_RS02305	COG0395	ABC-type sugar transport system, permease component
HVS_RS02315	COG1472	Belongs to the glycosyl hydrolase 3 family
HVS_RS02320	COG1070	Carbohydrate kinase
HVS_RS02340	COG0628	permease
HVS_RS02345	COG0194	GDP metabolic process
HVS_RS02350	COG0133	tryptophan synthase activity
HVS_RS02355	COG0159	tryptophan synthase activity
HVS_RS02360	COG2911	Protein conserved in bacteria
HVS_RS02360	COG3266	domain, Protein
HVS_RS02360	COG1361	Conserved repeat domain
HVS_RS02370	COG3409	Peptidoglycan-binding domain 1 protein
HVS_RS02370	COG3773	Cell wall hydrolase
HVS_RS02380	COG0372	Belongs to the citrate synthase family
HVS_RS02385	COG3279	Response regulator of the LytR AlgR family
HVS_RS02405	COG3852	Histidine kinase
HVS_RS02415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HVS_RS02430	COG0714	Associated with various cellular activities
HVS_RS02440	COG1305	Transglutaminase-like
HVS_RS02450	COG1674	ftsk spoiiie
HVS_RS02455	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HVS_RS02475	COG0768	penicillin binding
HVS_RS02480	COG0688	phosphatidylethanolamine metabolic process
HVS_RS02485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVS_RS02490	COG4733	cellulase activity
HVS_RS02490	COG4447	cellulose binding
HVS_RS02495	COG2911	Protein conserved in bacteria
HVS_RS02500	COG3266	domain, Protein
HVS_RS02500	COG2911	Protein conserved in bacteria
HVS_RS02500	COG1361	Conserved repeat domain
HVS_RS02505	COG1361	Conserved repeat domain
HVS_RS02505	COG3266	domain, Protein
HVS_RS02505	COG2911	Protein conserved in bacteria
HVS_RS02515	COG1361	Conserved repeat domain
HVS_RS02520	COG1361	Conserved repeat domain
HVS_RS02545	COG0542	response to heat
HVS_RS02570	COG1472	Belongs to the glycosyl hydrolase 3 family
HVS_RS02595	COG0525	valine-tRNA ligase activity
HVS_RS02620	COG0113	porphobilinogen synthase activity
HVS_RS02625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HVS_RS02630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HVS_RS02630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVS_RS02640	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HVS_RS02645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVS_RS02650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVS_RS02670	COG2873	o-acetylhomoserine
HVS_RS02685	COG0175	sulfate reduction
HVS_RS02710	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HVS_RS02715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HVS_RS02725	COG2172	sigma factor antagonist activity
HVS_RS02745	COG3464	Transposase
HVS_RS02750	COG2357	RelA SpoT domain protein
HVS_RS02755	COG1121	(ABC) transporter
HVS_RS02765	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HVS_RS02770	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HVS_RS02785	COG1484	DNA-dependent DNA replication
HVS_RS02790	COG4584	PFAM Integrase catalytic
HVS_RS02840	COG3464	Transposase
HVS_RS02855	COG0640	Transcriptional regulator
HVS_RS02860	COG1131	(ABC) transporter
HVS_RS02875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVS_RS02905	COG0640	Transcriptional regulator
HVS_RS02925	COG3209	COG3209 Rhs family protein
HVS_RS02950	COG3464	Transposase
HVS_RS02965	COG3620	sequence-specific DNA binding
HVS_RS02995	COG0745	RESPONSE REGULATOR receiver
HVS_RS03005	COG1131	(ABC) transporter
HVS_RS03040	COG2207	Transcriptional regulator
HVS_RS03040	COG3708	Transcriptional regulator
HVS_RS03070	COG0745	RESPONSE REGULATOR receiver
HVS_RS03085	COG2205	protein histidine kinase activity
HVS_RS03140	COG1361	Conserved repeat domain
HVS_RS03160	COG1228	amidohydrolase
HVS_RS03165	COG0802	atpase or kinase
HVS_RS03170	COG1214	PFAM Peptidase M22, glycoprotease
HVS_RS03175	COG0456	acetyltransferase
HVS_RS03180	COG1067	ATP-dependent peptidase activity
HVS_RS03195	COG0210	DNA helicase
HVS_RS03210	COG1611	Belongs to the LOG family
HVS_RS03250	COG0739	heme binding
HVS_RS03260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVS_RS03265	COG1120	ATPase activity
HVS_RS03290	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HVS_RS03295	COG1368	sulfuric ester hydrolase activity
HVS_RS03310	COG4305	rare lipoprotein A
HVS_RS03320	COG3464	Transposase
HVS_RS03325	COG2002	toxin-antitoxin pair type II binding
HVS_RS03345	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HVS_RS03350	COG0066	3-isopropylmalate dehydratase activity
HVS_RS03355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVS_RS03370	COG3775	system Galactitol-specific IIC component
HVS_RS03395	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVS_RS03440	COG3501	Rhs element vgr protein
HVS_RS03440	COG3409	Peptidoglycan-binding domain 1 protein
HVS_RS03580	COG0640	Transcriptional regulator
HVS_RS03600	COG1404	Belongs to the peptidase S8 family
HVS_RS03605	COG1404	Belongs to the peptidase S8 family
HVS_RS03625	COG3464	Transposase
HVS_RS03635	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HVS_RS03645	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HVS_RS03650	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HVS_RS03655	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HVS_RS03660	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HVS_RS03670	COG0629	single-stranded DNA binding
HVS_RS03680	COG1408	metallophosphoesterase
HVS_RS03700	COG1518	maintenance of DNA repeat elements
HVS_RS03715	COG0741	lytic transglycosylase activity
HVS_RS03715	COG1196	nuclear chromosome segregation
HVS_RS03715	COG0739	heme binding
HVS_RS03725	COG1937	Protein conserved in bacteria
HVS_RS03735	COG2217	Heavy metal translocating P-type atpase
HVS_RS03750	COG1361	Conserved repeat domain
HVS_RS03755	COG2911	Protein conserved in bacteria
HVS_RS04040	COG3464	Transposase
HVS_RS04115	COG1811	Na channel or pump
HVS_RS04125	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HVS_RS04145	COG4733	cellulase activity
HVS_RS04150	COG4733	cellulase activity
HVS_RS04150	COG4447	cellulose binding
HVS_RS04155	COG0673	inositol 2-dehydrogenase activity
HVS_RS04165	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HVS_RS04170	COG0514	ATP-dependent DNA helicase (RecQ)
HVS_RS04175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HVS_RS04190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HVS_RS04195	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HVS_RS04200	COG0438	transferase activity, transferring glycosyl groups
HVS_RS04205	COG3973	AAA domain
HVS_RS04210	COG0484	heat shock protein binding
HVS_RS04215	COG0542	response to heat
HVS_RS04220	COG4372	Transposase
HVS_RS04240	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVS_RS04270	COG1361	Conserved repeat domain
HVS_RS04270	COG2911	Protein conserved in bacteria
HVS_RS04270	COG3266	domain, Protein
HVS_RS04335	COG3464	Transposase
HVS_RS04340	COG3464	Transposase
HVS_RS04360	COG5433	transposase activity
HVS_RS04380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HVS_RS04390	COG1028	Short-chain dehydrogenase reductase Sdr
HVS_RS04395	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HVS_RS04405	COG4310	Domain of unknown function (DUF2172)
HVS_RS04415	COG2089	acid synthase
HVS_RS04445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HVS_RS04450	COG1088	dTDP-glucose 4,6-dehydratase activity
HVS_RS04510	COG0697	spore germination
HVS_RS04525	COG1136	(ABC) transporter
HVS_RS04550	COG0697	spore germination
HVS_RS04580	COG4974	Belongs to the 'phage' integrase family
HVS_RS04635	COG3464	Transposase
HVS_RS04680	COG4626	Terminase
HVS_RS04680	COG1802	Transcriptional regulator
HVS_RS04730	COG1131	(ABC) transporter
HVS_RS04755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVS_RS04800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HVS_RS04805	COG1191	sigma factor activity
HVS_RS04810	COG2755	lipolytic protein G-D-S-L family
HVS_RS04855	COG3866	Pectate lyase
HVS_RS04860	COG1609	Transcriptional regulator
HVS_RS04880	COG0318	PFAM AMP-dependent synthetase and ligase
HVS_RS04890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVS_RS04910	COG1131	(ABC) transporter
HVS_RS04935	COG4447	cellulose binding
HVS_RS04935	COG4733	cellulase activity
HVS_RS04950	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HVS_RS04960	COG1518	maintenance of DNA repeat elements
HVS_RS05040	COG2323	membrane
HVS_RS05050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HVS_RS05075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HVS_RS05080	COG1686	Belongs to the peptidase S11 family
HVS_RS05105	COG1752	Esterase of the alpha-beta hydrolase superfamily
HVS_RS05120	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HVS_RS05125	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HVS_RS05125	COG0248	Ppx GppA phosphatase
HVS_RS05130	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HVS_RS05135	COG0116	Belongs to the methyltransferase superfamily
HVS_RS05135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HVS_RS05140	COG0564	pseudouridine synthase activity
HVS_RS05150	COG0297	glycogen (starch) synthase activity
HVS_RS05160	COG1482	cell wall glycoprotein biosynthetic process
HVS_RS05175	COG2197	response regulator
HVS_RS05195	COG1331	Highly conserved protein containing a thioredoxin domain
HVS_RS05200	COG1283	sodium-dependent phosphate transmembrane transporter activity
HVS_RS05205	COG1489	DNA binding
HVS_RS05210	COG2340	Cysteine-rich secretory protein family
HVS_RS05220	COG0187	DNA topoisomerase II activity
HVS_RS05230	COG0473	3-isopropylmalate dehydrogenase activity
HVS_RS05240	COG1690	Belongs to the RtcB family
HVS_RS05250	COG0556	nucleotide-excision repair
HVS_RS05255	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HVS_RS05260	COG2502	aspartate--ammonia ligase
HVS_RS05265	COG0017	Asparaginyl-tRNA synthetase
HVS_RS05270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HVS_RS05275	COG0390	transport system, permease component
HVS_RS05300	COG2059	Chromate
HVS_RS05315	COG1595	DNA-templated transcription, initiation
HVS_RS05335	COG0835	chemotaxis
HVS_RS05340	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HVS_RS05345	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVS_RS05370	COG0424	maF-like protein
HVS_RS05375	COG1077	Cell shape determining protein MreB Mrl
HVS_RS05390	COG0768	penicillin binding
HVS_RS05395	COG0850	regulation of cytokinetic process
HVS_RS05400	COG2894	cell division
HVS_RS05405	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HVS_RS05410	COG1803	Methylglyoxal synthase
HVS_RS05420	COG1994	Peptidase M50
HVS_RS05425	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HVS_RS05445	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HVS_RS05445	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HVS_RS05450	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HVS_RS05460	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HVS_RS05465	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HVS_RS05485	COG3464	Transposase
HVS_RS05495	COG2323	membrane
HVS_RS05500	COG0569	domain protein
HVS_RS05510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HVS_RS05550	COG0631	protein serine/threonine phosphatase activity
HVS_RS05560	COG3464	Transposase
HVS_RS05575	COG1132	(ABC) transporter
HVS_RS05640	COG1674	ftsk spoiiie
HVS_RS05650	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVS_RS05660	COG2801	Transposase and inactivated derivatives
HVS_RS05750	COG3328	transposase activity
HVS_RS05855	COG0515	serine threonine protein kinase
HVS_RS05870	COG1686	Belongs to the peptidase S11 family
HVS_RS05890	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HVS_RS05930	COG0628	permease
HVS_RS06000	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HVS_RS06005	COG1516	flagellar protein fliS
HVS_RS06015	COG1073	alpha beta
HVS_RS06020	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HVS_RS06025	COG2207	Transcriptional regulator
HVS_RS06035	COG1361	Conserved repeat domain
HVS_RS06035	COG3266	domain, Protein
HVS_RS06035	COG2911	Protein conserved in bacteria
HVS_RS06055	COG1191	sigma factor activity
HVS_RS06060	COG0473	3-isopropylmalate dehydrogenase activity
HVS_RS06065	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HVS_RS06075	COG0302	gtp cyclohydrolase
HVS_RS06095	COG1496	oxidoreductase activity
HVS_RS06105	COG3464	Transposase
HVS_RS06110	COG0537	adenosine 5'-monophosphoramidase activity
HVS_RS06115	COG1361	Conserved repeat domain
HVS_RS06130	COG0489	protein tyrosine kinase activity
HVS_RS06145	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HVS_RS06155	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HVS_RS06165	COG1022	Amp-dependent synthetase and ligase
HVS_RS06200	COG1132	(ABC) transporter
HVS_RS06215	COG0519	Catalyzes the synthesis of GMP from XMP
HVS_RS06225	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HVS_RS06230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HVS_RS06235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HVS_RS06240	COG0138	bifunctional purine biosynthesis protein purh
HVS_RS06245	COG0151	Belongs to the GarS family
HVS_RS06255	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HVS_RS06260	COG1713	HD superfamily hydrolase involved in NAD metabolism
HVS_RS06265	COG0799	negative regulation of ribosome biogenesis
HVS_RS06270	COG0495	leucyl-tRNA aminoacylation
HVS_RS06275	COG1686	Belongs to the peptidase S11 family
HVS_RS06280	COG1596	polysaccharide export
HVS_RS06280	COG1555	photosystem II stabilization
HVS_RS06295	COG2373	Large extracellular alpha-helical protein
HVS_RS06310	COG0768	penicillin binding
HVS_RS06315	COG0826	peptidase U32
HVS_RS06320	COG4122	O-methyltransferase activity
HVS_RS06325	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HVS_RS06330	COG1217	gtp-binding protein TYPA
HVS_RS06340	COG0052	Belongs to the universal ribosomal protein uS2 family
HVS_RS06345	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HVS_RS06350	COG0528	UMP kinase activity
HVS_RS06355	COG0233	cytoplasmic translational termination
HVS_RS06370	COG0575	Belongs to the CDS family
HVS_RS06375	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HVS_RS06380	COG0750	zinc metalloprotease
HVS_RS06385	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HVS_RS06390	COG0463	Glycosyl transferase, family 2
HVS_RS06395	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HVS_RS06400	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HVS_RS06405	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HVS_RS06410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVS_RS06415	COG3459	Glycosyltransferase 36 associated
HVS_RS06435	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HVS_RS06440	COG0542	response to heat
HVS_RS06445	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HVS_RS06450	COG1686	Belongs to the peptidase S11 family
HVS_RS06455	COG1509	lysine 2,3-aminomutase activity
HVS_RS06460	COG0456	acetyltransferase
HVS_RS06465	COG3870	Protein conserved in bacteria
HVS_RS06470	COG2078	PFAM AMMECR1 domain protein
HVS_RS06470	COG3885	ferrous iron binding
HVS_RS06480	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HVS_RS06490	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HVS_RS06495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HVS_RS06500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HVS_RS06530	COG3328	transposase activity
HVS_RS06535	COG3464	Transposase
HVS_RS06545	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HVS_RS06580	COG0514	ATP-dependent DNA helicase (RecQ)
HVS_RS06585	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HVS_RS06595	COG3586	endonuclease activity
HVS_RS06600	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HVS_RS06650	COG1956	GAF domain-containing protein
HVS_RS06685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVS_RS06780	COG3464	Transposase
HVS_RS06880	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HVS_RS06890	COG0730	response to heat
HVS_RS06895	COG0730	response to heat
HVS_RS06910	COG4447	cellulose binding
HVS_RS06910	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HVS_RS06920	COG3326	Membrane
HVS_RS06925	COG0668	transmembrane transport
HVS_RS06930	COG0708	Exodeoxyribonuclease III
HVS_RS06935	COG0778	Nitroreductase
HVS_RS06940	COG5297	Belongs to the glycosyl hydrolase family 6
HVS_RS06950	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HVS_RS06965	COG3547	Transposase (IS116 IS110 IS902 family)
HVS_RS06995	COG0726	polysaccharide deacetylase
HVS_RS07025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HVS_RS07030	COG0242	peptide deformylase activity
HVS_RS07035	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HVS_RS07045	COG2738	Putative neutral zinc metallopeptidase
HVS_RS07050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HVS_RS07050	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HVS_RS07055	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HVS_RS07060	COG0631	protein serine/threonine phosphatase activity
HVS_RS07065	COG2815	serine threonine protein kinase
HVS_RS07065	COG0515	serine threonine protein kinase
HVS_RS07070	COG1162	GTPase activity
HVS_RS07075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVS_RS07090	COG0436	Aminotransferase
HVS_RS07095	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HVS_RS07105	COG2204	response regulator
HVS_RS07115	COG1030	water channel activity
HVS_RS07135	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HVS_RS07140	COG2022	thiamine diphosphate biosynthetic process
HVS_RS07140	COG2104	thiamine diphosphate biosynthetic process
HVS_RS07145	COG2022	thiamine diphosphate biosynthetic process
HVS_RS07150	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HVS_RS07160	COG0352	thiamine-phosphate diphosphorylase activity
HVS_RS07165	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HVS_RS07175	COG0791	NLP P60 protein
HVS_RS07180	COG0658	competence protein
HVS_RS07180	COG2333	competence protein COMEC
HVS_RS07185	COG1466	dna polymerase III delta subunit
HVS_RS07190	COG0268	Binds directly to 16S ribosomal RNA
HVS_RS07200	COG3464	Transposase
HVS_RS07205	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVS_RS07205	COG2247	cell wall binding repeat
HVS_RS07215	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HVS_RS07235	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HVS_RS07245	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HVS_RS07255	COG0280	phosphate acetyltransferase
HVS_RS07260	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HVS_RS07270	COG1674	ftsk spoiiie
HVS_RS07275	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HVS_RS07285	COG1418	mRNA catabolic process
HVS_RS07290	COG1692	metallophosphoesterase
HVS_RS07295	COG2359	stage V sporulation protein S
HVS_RS07305	COG1606	tRNA processing
HVS_RS07325	COG0438	transferase activity, transferring glycosyl groups
HVS_RS07330	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HVS_RS07335	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HVS_RS07350	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HVS_RS07355	COG3879	Bacterial protein of unknown function (DUF881)
HVS_RS07400	COG1702	phosphate starvation-inducible protein PhoH
HVS_RS07405	COG1480	7TM receptor with intracellular HD hydrolase
HVS_RS07410	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HVS_RS07415	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HVS_RS07420	COG0295	cytidine deaminase activity
HVS_RS07425	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HVS_RS07435	COG1381	Involved in DNA repair and RecF pathway recombination
HVS_RS07450	COG4584	PFAM Integrase catalytic
HVS_RS07460	COG0301	tRNA thio-modification
HVS_RS07465	COG2720	vancomycin resistance protein
HVS_RS07475	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HVS_RS07485	COG0714	Associated with various cellular activities
HVS_RS07490	COG1305	Transglutaminase-like
HVS_RS07495	COG0039	L-malate dehydrogenase activity
HVS_RS07505	COG1058	Belongs to the CinA family
HVS_RS07505	COG1546	Belongs to the CinA family
HVS_RS07510	COG0728	peptidoglycan biosynthetic process
HVS_RS07515	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HVS_RS07545	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HVS_RS07580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HVS_RS07595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVS_RS07600	COG0134	indole-3-glycerol-phosphate synthase activity
HVS_RS07615	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HVS_RS07660	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVS_RS07660	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HVS_RS07665	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVS_RS07685	COG4864	UPF0365 protein
HVS_RS07690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVS_RS07695	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HVS_RS07700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HVS_RS07725	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HVS_RS07760	COG3541	Predicted nucleotidyltransferase
HVS_RS07770	COG3940	Belongs to the glycosyl hydrolase 43 family
HVS_RS07780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVS_RS07785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVS_RS07805	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HVS_RS07810	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVS_RS07815	COG5297	Belongs to the glycosyl hydrolase family 6
HVS_RS07815	COG3250	beta-galactosidase activity
HVS_RS07820	COG3266	domain, Protein
HVS_RS07820	COG2911	Protein conserved in bacteria
HVS_RS07820	COG1361	Conserved repeat domain
HVS_RS07825	COG2911	Protein conserved in bacteria
HVS_RS07825	COG1361	Conserved repeat domain
HVS_RS07825	COG3266	domain, Protein
HVS_RS07835	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HVS_RS07845	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HVS_RS07850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HVS_RS07860	COG1959	2 iron, 2 sulfur cluster binding
HVS_RS07890	COG3853	Toxic anion resistance protein (TelA)
HVS_RS07905	COG2310	stress, protein
HVS_RS07910	COG2310	stress, protein
HVS_RS07915	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HVS_RS07925	COG1358	cellular component organization or biogenesis
HVS_RS07945	COG3693	PFAM glycoside hydrolase, family 10
HVS_RS07950	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HVS_RS07955	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HVS_RS07960	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVS_RS07965	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVS_RS07995	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HVS_RS08000	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HVS_RS08005	COG4974	Belongs to the 'phage' integrase family
HVS_RS08020	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HVS_RS08020	COG2199	diguanylate cyclase activity
HVS_RS08030	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HVS_RS08035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HVS_RS08040	COG0482	sulfurtransferase activity
HVS_RS08045	COG0822	iron-sulfur transferase activity
HVS_RS08060	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HVS_RS08065	COG0105	UTP biosynthetic process
HVS_RS08070	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HVS_RS08075	COG0539	negative regulation of cytoplasmic translation
HVS_RS08075	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HVS_RS08080	COG0204	Acyl-transferase
HVS_RS08085	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HVS_RS08090	COG4401	Chorismate mutase type I
HVS_RS08105	COG2081	HI0933 family
HVS_RS08125	COG4447	cellulose binding
HVS_RS08125	COG4733	cellulase activity
HVS_RS08140	COG0511	ligase activity, forming carbon-carbon bonds
HVS_RS08145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HVS_RS08155	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HVS_RS08160	COG0010	Belongs to the arginase family
HVS_RS08165	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HVS_RS08215	COG1187	pseudouridine synthase activity
HVS_RS08220	COG3874	Sporulation protein YtfJ
HVS_RS08230	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HVS_RS08235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HVS_RS08240	COG0180	Tryptophanyl-tRNA synthetase
HVS_RS08250	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HVS_RS08250	COG0617	tRNA 3'-terminal CCA addition
HVS_RS08250	COG3620	sequence-specific DNA binding
HVS_RS08260	COG1368	sulfuric ester hydrolase activity
HVS_RS08340	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVS_RS08360	COG0336	Belongs to the RNA methyltransferase TrmD family
HVS_RS08365	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HVS_RS08370	COG1837	Belongs to the UPF0109 family
HVS_RS08375	COG0228	four-way junction DNA binding
HVS_RS08380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HVS_RS08385	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HVS_RS08390	COG0569	domain protein
HVS_RS08390	COG0189	ligase activity
HVS_RS08395	COG0189	ligase activity
HVS_RS08400	COG1388	LysM domain
HVS_RS08405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HVS_RS08410	COG1923	regulation of RNA biosynthetic process
HVS_RS08415	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HVS_RS08420	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HVS_RS08425	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HVS_RS08440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HVS_RS08445	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HVS_RS08460	COG1686	Belongs to the peptidase S11 family
HVS_RS08465	COG1686	Belongs to the peptidase S11 family
HVS_RS08475	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HVS_RS08510	COG1725	Transcriptional regulator
HVS_RS08525	COG0546	phosphoglycolate phosphatase activity
HVS_RS08555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVS_RS08560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HVS_RS08565	COG0156	8-amino-7-oxononanoate synthase activity
HVS_RS08570	COG2267	carboxylic ester hydrolase activity
HVS_RS08575	COG4106	trans-aconitate 2-methyltransferase activity
HVS_RS08580	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HVS_RS08585	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVS_RS08600	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HVS_RS08605	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HVS_RS08620	COG1570	exodeoxyribonuclease VII activity
HVS_RS08625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HVS_RS08640	COG1302	Protein conserved in bacteria
HVS_RS08680	COG3854	ATPases associated with a variety of cellular activities
HVS_RS08690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HVS_RS08695	COG0006	proline dipeptidase activity
HVS_RS08700	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HVS_RS08705	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HVS_RS08715	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HVS_RS08725	COG0012	GTP binding
HVS_RS08735	COG0772	Belongs to the SEDS family
HVS_RS08740	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HVS_RS08745	COG3706	GGDEF domain
HVS_RS08765	COG0237	dephospho-CoA kinase activity
HVS_RS08770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVS_RS08770	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVS_RS08785	COG0552	protein localization to endoplasmic reticulum
HVS_RS08795	COG2359	stage V sporulation protein S
HVS_RS08805	COG0571	ribonuclease III activity
HVS_RS08810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVS_RS08815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HVS_RS08820	COG1028	Short-chain dehydrogenase reductase Sdr
HVS_RS08825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HVS_RS08830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HVS_RS08835	COG0416	fatty acid biosynthetic process
HVS_RS08840	COG2030	dehydratase
HVS_RS08845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVS_RS08850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HVS_RS08870	COG0406	alpha-ribazole phosphatase activity
HVS_RS08880	COG3507	Belongs to the glycosyl hydrolase 43 family
HVS_RS08880	COG2382	esterase
HVS_RS08880	COG3693	PFAM glycoside hydrolase, family 10
HVS_RS08890	COG0167	dihydroorotate dehydrogenase activity
HVS_RS08895	COG0543	2 iron, 2 sulfur cluster binding
HVS_RS08905	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HVS_RS08910	COG0540	Belongs to the ATCase OTCase family
HVS_RS08920	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HVS_RS08955	COG1862	Preprotein translocase
HVS_RS08960	COG0343	queuine tRNA-ribosyltransferase activity
HVS_RS08965	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HVS_RS08970	COG2247	cell wall binding repeat
HVS_RS08970	COG2385	sporulation resulting in formation of a cellular spore
HVS_RS08975	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HVS_RS08980	COG0527	aspartate kinase activity
HVS_RS08985	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HVS_RS08990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HVS_RS08995	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVS_RS09015	COG1191	sigma factor activity
HVS_RS09035	COG2273	Hydrolase Family 16
HVS_RS09045	COG3507	Belongs to the glycosyl hydrolase 43 family
HVS_RS09050	COG3507	Belongs to the glycosyl hydrolase 43 family
HVS_RS09050	COG3693	PFAM glycoside hydrolase, family 10
HVS_RS09050	COG2382	esterase
HVS_RS09055	COG0789	Transcriptional regulator
HVS_RS09055	COG4978	Transcriptional regulator
HVS_RS09115	COG0534	Mate efflux family protein
HVS_RS09135	COG0714	Associated with various cellular activities
HVS_RS09150	COG1131	(ABC) transporter
HVS_RS09165	COG2188	Transcriptional regulator
HVS_RS09170	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HVS_RS09185	COG1484	DNA-dependent DNA replication
HVS_RS09190	COG4584	PFAM Integrase catalytic
HVS_RS09195	COG0628	permease
HVS_RS09200	COG2003	Belongs to the UPF0758 family
HVS_RS09205	COG0792	nuclease activity
HVS_RS09210	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVS_RS09220	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HVS_RS09225	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HVS_RS09235	COG3464	Transposase
HVS_RS09240	COG0335	large ribosomal subunit rRNA binding
HVS_RS09245	COG4447	cellulose binding
HVS_RS09245	COG4733	cellulase activity
HVS_RS09255	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HVS_RS09285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVS_RS09290	COG0358	DNA primase activity
HVS_RS09295	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HVS_RS09310	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HVS_RS09315	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HVS_RS09320	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HVS_RS09325	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVS_RS09330	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVS_RS09335	COG1418	mRNA catabolic process
HVS_RS09350	COG0564	pseudouridine synthase activity
HVS_RS09355	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HVS_RS09375	COG4124	Belongs to the glycosyl hydrolase 26 family
HVS_RS09400	COG0840	transmembrane signaling receptor activity
HVS_RS09445	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HVS_RS09445	COG2755	lipolytic protein G-D-S-L family
HVS_RS09455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVS_RS09485	COG0714	Associated with various cellular activities
HVS_RS09505	COG1686	Belongs to the peptidase S11 family
HVS_RS09510	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HVS_RS09515	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HVS_RS09520	COG4974	Belongs to the 'phage' integrase family
HVS_RS09525	COG1300	Membrane
HVS_RS09530	COG0494	nUDIX hydrolase
HVS_RS09535	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HVS_RS09560	COG0697	spore germination
HVS_RS09585	COG1509	lysine 2,3-aminomutase activity
HVS_RS09590	COG0328	RNA-DNA hybrid ribonuclease activity
HVS_RS09595	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVS_RS09625	COG3599	regulation of cell shape
HVS_RS09635	COG1799	cell septum assembly
HVS_RS09640	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HVS_RS09650	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HVS_RS09655	COG0564	pseudouridine synthase activity
HVS_RS09665	COG0745	RESPONSE REGULATOR receiver
HVS_RS09670	COG3850	Histidine kinase
HVS_RS09670	COG4999	Histidine kinase
HVS_RS09670	COG2205	protein histidine kinase activity
HVS_RS09670	COG3437	response regulator, receiver
HVS_RS09675	COG2201	protein-glutamate methylesterase activity
HVS_RS09685	COG0835	chemotaxis
HVS_RS09690	COG0643	Histidine kinase
HVS_RS09690	COG2198	Histidine kinase
HVS_RS09695	COG2201	protein-glutamate methylesterase activity
HVS_RS09700	COG0745	RESPONSE REGULATOR receiver
HVS_RS09705	COG0750	zinc metalloprotease
HVS_RS09710	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HVS_RS09710	COG2755	lipolytic protein G-D-S-L family
HVS_RS09740	COG0497	DNA recombination
HVS_RS09745	COG1438	arginine binding
HVS_RS09750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HVS_RS09755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVS_RS09790	COG0463	Glycosyl transferase, family 2
HVS_RS09790	COG0457	Tetratricopeptide repeat
HVS_RS09810	COG1028	Short-chain dehydrogenase reductase Sdr
HVS_RS09815	COG1083	cytidylyl-transferase
HVS_RS09825	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HVS_RS09835	COG2089	acid synthase
HVS_RS09840	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HVS_RS09850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVS_RS09865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HVS_RS09875	COG1131	(ABC) transporter
HVS_RS09895	COG1595	DNA-templated transcription, initiation
HVS_RS09905	COG1131	(ABC) transporter
HVS_RS09925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVS_RS09930	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HVS_RS09940	COG0463	Glycosyl transferase, family 2
HVS_RS09940	COG0457	Tetratricopeptide repeat
HVS_RS09955	COG0740	serine-type endopeptidase activity
HVS_RS09990	COG4969	Belongs to the N-Me-Phe pilin family
HVS_RS09995	COG1459	type II secretion system
HVS_RS10005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVS_RS10010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HVS_RS10020	COG0612	Peptidase, M16
HVS_RS10025	COG1185	polyribonucleotide nucleotidyltransferase activity
HVS_RS10030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HVS_RS10035	COG2848	UPF0210 protein
HVS_RS10040	COG3830	Belongs to the UPF0237 family
HVS_RS10060	COG4447	cellulose binding
HVS_RS10065	COG1191	sigma factor activity
HVS_RS10070	COG2176	DNA-directed DNA polymerase activity
HVS_RS10075	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVS_RS10110	COG1191	sigma factor activity
HVS_RS10120	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HVS_RS10125	COG1776	CheC inhibitor of MCP methylation
HVS_RS10135	COG0643	Histidine kinase
HVS_RS10135	COG2198	Histidine kinase
HVS_RS10140	COG2201	protein-glutamate methylesterase activity
HVS_RS10155	COG1419	protein localization to endoplasmic reticulum
HVS_RS10160	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVS_RS10165	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVS_RS10170	COG1684	flagellar biosynthetic protein fliR
HVS_RS10175	COG1987	bacterial-type flagellum assembly
HVS_RS10180	COG1338	Plays a role in the flagellum-specific transport system
HVS_RS10190	COG2201	protein-glutamate methylesterase activity
HVS_RS10195	COG1776	CheC inhibitor of MCP methylation
HVS_RS10195	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVS_RS10200	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVS_RS10210	COG1582	Flagellar protein (FlbD)
HVS_RS10225	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HVS_RS10245	COG1157	protein secretion by the type III secretion system
HVS_RS10255	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVS_RS10265	COG1677	Flagellar hook-basal body complex protein FliE
HVS_RS10270	COG1558	bacterial-type flagellum-dependent cell motility
HVS_RS10275	COG1815	bacterial-type flagellum-dependent cell motility
HVS_RS10280	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HVS_RS10285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVS_RS10290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HVS_RS10290	COG0758	DNA mediated transformation
HVS_RS10295	COG0606	chelatase, subunit chli
HVS_RS10305	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HVS_RS10310	COG1873	PFAM PRC-barrel domain
HVS_RS10315	COG1191	sigma factor activity
HVS_RS10320	COG1191	sigma factor activity
HVS_RS10330	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HVS_RS10335	COG0849	cell division
HVS_RS10340	COG3856	small basic protein
HVS_RS10350	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HVS_RS10355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HVS_RS10360	COG3442	glutamine amidotransferase
HVS_RS10375	COG1122	ATPase activity
HVS_RS10415	COG1136	(ABC) transporter
HVS_RS10425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HVS_RS10430	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HVS_RS10435	COG0772	Belongs to the SEDS family
HVS_RS10440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HVS_RS10445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HVS_RS10450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HVS_RS10455	COG0768	penicillin binding
HVS_RS10465	COG0275	rRNA processing
HVS_RS10470	COG2001	Belongs to the MraZ family
HVS_RS10480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HVS_RS10485	COG0612	Peptidase, M16
HVS_RS10490	COG0612	Peptidase, M16
HVS_RS10500	COG0196	riboflavin kinase activity
HVS_RS10505	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HVS_RS10510	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HVS_RS10515	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HVS_RS10520	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HVS_RS10530	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HVS_RS10535	COG0195	Participates in both transcription termination and antitermination
HVS_RS10540	COG0779	Required for maturation of 30S ribosomal subunits
HVS_RS10560	COG0697	spore germination
HVS_RS10570	COG1361	Conserved repeat domain
HVS_RS10575	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HVS_RS10585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HVS_RS10615	COG0628	permease
HVS_RS10620	COG1193	negative regulation of DNA recombination
HVS_RS10630	COG2201	protein-glutamate methylesterase activity
HVS_RS10635	COG2205	protein histidine kinase activity
HVS_RS10645	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HVS_RS10650	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HVS_RS10655	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HVS_RS10660	COG1160	GTP binding
HVS_RS10665	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HVS_RS10680	COG5002	protein histidine kinase activity
HVS_RS10680	COG3850	Histidine kinase
HVS_RS10685	COG0745	RESPONSE REGULATOR receiver
HVS_RS10690	COG3458	cephalosporin-C deacetylase activity
HVS_RS10710	COG0824	Thioesterase
HVS_RS10715	COG0205	6-phosphofructokinase activity
HVS_RS10735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HVS_RS10750	COG3314	Sporulation integral membrane protein YlbJ
HVS_RS10780	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVS_RS10780	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVS_RS10780	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVS_RS10780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HVS_RS10795	COG1136	(ABC) transporter
HVS_RS10800	COG0024	Methionine aminopeptidase
HVS_RS10805	COG5002	protein histidine kinase activity
HVS_RS10805	COG3850	Histidine kinase
HVS_RS10815	COG0318	PFAM AMP-dependent synthetase and ligase
HVS_RS10820	COG0656	L-ascorbic acid biosynthetic process
HVS_RS10855	COG2832	Protein of unknown function (DUF454)
HVS_RS10870	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HVS_RS10875	COG0742	ribosomal rna small subunit methyltransferase
HVS_RS10880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HVS_RS10885	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HVS_RS10895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HVS_RS10900	COG0297	glycogen (starch) synthase activity
HVS_RS10905	COG2199	diguanylate cyclase activity
HVS_RS10905	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HVS_RS10915	COG5002	protein histidine kinase activity
HVS_RS10920	COG0745	RESPONSE REGULATOR receiver
HVS_RS10935	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HVS_RS10945	COG0735	belongs to the Fur family
HVS_RS10950	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
HVS_RS10975	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HVS_RS10990	COG1323	Belongs to the UPF0348 family
HVS_RS10995	COG0840	transmembrane signaling receptor activity
HVS_RS11000	COG3464	Transposase
HVS_RS11010	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HVS_RS11015	COG5297	Belongs to the glycosyl hydrolase family 6
HVS_RS11015	COG2273	Hydrolase Family 16
HVS_RS11025	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HVS_RS11040	COG3693	PFAM glycoside hydrolase, family 10
HVS_RS11055	COG0574	Belongs to the PEP-utilizing enzyme family
HVS_RS11055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVS_RS11060	COG0423	glycine-tRNA ligase activity
HVS_RS11065	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HVS_RS11070	COG1758	RNA polymerase activity
HVS_RS11075	COG2052	Domain of unknown function (DUF370)
HVS_RS11080	COG1561	YicC-like family, N-terminal region
HVS_RS11085	COG2201	protein-glutamate methylesterase activity
HVS_RS11090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HVS_RS11095	COG2264	protein methyltransferase activity
HVS_RS11100	COG0484	heat shock protein binding
HVS_RS11105	COG0443	Heat shock 70 kDa protein
HVS_RS11110	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HVS_RS11115	COG1420	regulation of RNA biosynthetic process
HVS_RS11120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVS_RS11125	COG0481	GTPase activity
HVS_RS11150	COG0681	Belongs to the peptidase S26 family
HVS_RS11155	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HVS_RS11160	COG0124	histidyl-tRNA synthetase
HVS_RS11170	COG1490	D-aminoacyl-tRNA deacylase activity
HVS_RS11175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVS_RS11185	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HVS_RS11185	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HVS_RS11190	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HVS_RS11195	COG0629	single-stranded DNA binding
HVS_RS11205	COG0493	'glutamate synthase
HVS_RS11205	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVS_RS11215	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HVS_RS11220	COG1691	(AIR) carboxylase
HVS_RS11250	COG0436	Aminotransferase
HVS_RS11255	COG1522	sequence-specific DNA binding
HVS_RS11265	COG3118	belongs to the thioredoxin family
HVS_RS11285	COG1595	DNA-templated transcription, initiation
HVS_RS11300	COG0285	dihydrofolate synthase activity
HVS_RS11305	COG0653	protein targeting
HVS_RS11320	COG4496	protein, YerC YecD
HVS_RS11325	COG3464	Transposase
HVS_RS11350	COG0166	Belongs to the GPI family
HVS_RS11360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HVS_RS11360	COG0072	phenylalanine-tRNA ligase activity
HVS_RS11365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HVS_RS11370	COG2723	6-phospho-beta-galactosidase activity
HVS_RS11380	COG0393	Putative heavy-metal-binding
HVS_RS11405	COG1074	ATP-dependent DNA helicase activity
HVS_RS11435	COG0840	transmembrane signaling receptor activity
HVS_RS11480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HVS_RS11485	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HVS_RS11495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HVS_RS11500	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVS_RS11500	COG2247	cell wall binding repeat
HVS_RS11510	COG2255	four-way junction helicase activity
HVS_RS11515	COG0632	four-way junction helicase activity
HVS_RS11520	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HVS_RS11535	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HVS_RS11545	COG1534	Rna-binding protein
HVS_RS11550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HVS_RS11555	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HVS_RS11565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HVS_RS11590	COG3906	Belongs to the UPF0473 family
HVS_RS11595	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HVS_RS11600	COG0667	Aldo Keto reductase
HVS_RS11605	COG4472	Bacterial protein of unknown function (DUF965)
HVS_RS11610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HVS_RS11620	COG1683	Conserved Protein
HVS_RS11625	COG0557	exoribonuclease II activity
HVS_RS11640	COG0148	phosphopyruvate hydratase activity
HVS_RS11680	COG0714	Associated with various cellular activities
HVS_RS11740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVS_RS11765	COG4447	cellulose binding
HVS_RS11770	COG1191	sigma factor activity
HVS_RS11775	COG3693	PFAM glycoside hydrolase, family 10
HVS_RS11780	COG1649	PFAM Uncharacterised BCR, COG1649
HVS_RS11785	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVS_RS11795	COG3464	Transposase
HVS_RS11830	COG1573	uracil-dna glycosylase
HVS_RS11835	COG1573	uracil-dna glycosylase
HVS_RS11840	COG0602	queuosine metabolic process
HVS_RS11845	COG0720	synthase
HVS_RS11850	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HVS_RS11865	COG1988	membrane-bound metal-dependent
HVS_RS11870	COG1316	TRANSCRIPTIONal
HVS_RS11880	COG0463	Glycosyl transferase, family 2
HVS_RS11915	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HVS_RS11945	COG0745	RESPONSE REGULATOR receiver
HVS_RS11950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HVS_RS11955	COG4565	transcriptional regulatory protein
HVS_RS11960	COG0116	Belongs to the methyltransferase superfamily
HVS_RS11965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVS_RS11970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVS_RS11975	COG1116	anion transmembrane transporter activity
HVS_RS11980	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HVS_RS11985	COG0149	triose-phosphate isomerase activity
HVS_RS11990	COG0126	phosphoglycerate kinase activity
HVS_RS12020	COG0318	PFAM AMP-dependent synthetase and ligase
HVS_RS12025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HVS_RS12030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HVS_RS12035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HVS_RS12050	COG2195	Cleaves the N-terminal amino acid of tripeptides
HVS_RS12055	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HVS_RS12070	COG2172	sigma factor antagonist activity
HVS_RS12075	COG1366	Belongs to the anti-sigma-factor antagonist family
HVS_RS12085	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVS_RS12090	COG1481	regulation of sporulation
HVS_RS12100	COG1660	Displays ATPase and GTPase activities
HVS_RS12105	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HVS_RS12110	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HVS_RS12130	COG4753	response regulator
HVS_RS12130	COG2207	Transcriptional regulator
HVS_RS12145	COG1187	pseudouridine synthase activity
HVS_RS12150	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HVS_RS12150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HVS_RS12155	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HVS_RS12160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HVS_RS12165	COG0840	transmembrane signaling receptor activity
HVS_RS12175	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HVS_RS12190	COG0527	aspartate kinase activity
HVS_RS12195	COG0460	homoserine dehydrogenase
HVS_RS12200	COG4492	Belongs to the UPF0735 family
HVS_RS12210	COG3464	Transposase
HVS_RS12215	COG1472	Belongs to the glycosyl hydrolase 3 family
HVS_RS12220	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HVS_RS12225	COG0402	S-adenosylhomocysteine deaminase activity
HVS_RS12235	COG1136	(ABC) transporter
HVS_RS12245	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HVS_RS12280	COG1131	(ABC) transporter
HVS_RS12295	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HVS_RS12320	COG0395	ABC-type sugar transport system, permease component
HVS_RS12335	COG1924	4 iron, 4 sulfur cluster binding
HVS_RS12350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVS_RS12355	COG0191	fructose-bisphosphate aldolase activity
HVS_RS12360	COG0205	6-phosphofructokinase activity
HVS_RS12365	COG1882	Formate acetyltransferase
HVS_RS12390	COG5002	protein histidine kinase activity
HVS_RS12415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HVS_RS12425	COG0428	transporter
HVS_RS12430	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HVS_RS12445	COG0662	Cupin 2, conserved barrel domain protein
HVS_RS12475	COG3949	Membrane
HVS_RS12485	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HVS_RS12490	COG3464	Transposase
HVS_RS12510	COG4584	PFAM Integrase catalytic
HVS_RS12515	COG2390	Transcriptional regulator
HVS_RS12515	COG4584	PFAM Integrase catalytic
HVS_RS12535	COG0488	(ABC) transporter
HVS_RS12550	COG1132	(ABC) transporter
HVS_RS12555	COG1132	(ABC) transporter
HVS_RS12585	COG0037	tRNA processing
HVS_RS12595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HVS_RS12600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HVS_RS12615	COG1408	metallophosphoesterase
HVS_RS12630	COG0542	response to heat
HVS_RS12635	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HVS_RS12640	COG0556	nucleotide-excision repair
HVS_RS12660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HVS_RS12665	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HVS_RS12670	COG0287	Prephenate dehydrogenase
HVS_RS12675	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HVS_RS12680	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HVS_RS12685	COG0488	(ABC) transporter
HVS_RS12690	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVS_RS12700	COG2094	Belongs to the DNA glycosylase MPG family
HVS_RS12715	COG0432	Pfam Uncharacterised protein family UPF0047
HVS_RS12730	COG4221	oxidoreductase activity
HVS_RS12750	COG0714	Associated with various cellular activities
HVS_RS12755	COG1668	transmembrane transport
HVS_RS12765	COG4152	abc transporter atp-binding protein
HVS_RS12785	COG2273	Hydrolase Family 16
HVS_RS12795	COG1361	Conserved repeat domain
HVS_RS12805	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HVS_RS12810	COG2273	Hydrolase Family 16
HVS_RS12815	COG3291	Pkd domain containing protein
HVS_RS12820	COG2755	lipolytic protein G-D-S-L family
HVS_RS12820	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HVS_RS12825	COG3693	PFAM glycoside hydrolase, family 10
HVS_RS12840	COG0613	PHP domain protein
HVS_RS12850	COG0741	lytic transglycosylase activity
HVS_RS12855	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HVS_RS12860	COG1968	undecaprenyl-diphosphatase activity
HVS_RS12865	COG0470	DNA polymerase III
HVS_RS12865	COG1067	ATP-dependent peptidase activity
HVS_RS12880	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HVS_RS12885	COG0740	serine-type endopeptidase activity
HVS_RS12890	COG0544	peptidyl-prolyl cis-trans isomerase activity
HVS_RS12900	COG0322	excinuclease ABC activity
HVS_RS12910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVS_RS12915	COG5662	AntiSigma factor
HVS_RS12920	COG1595	DNA-templated transcription, initiation
HVS_RS12925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HVS_RS12930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HVS_RS12935	COG0049	tRNA binding
HVS_RS12940	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HVS_RS12945	COG1358	cellular component organization or biogenesis
HVS_RS12950	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HVS_RS12955	COG0085	RNA polymerase activity
HVS_RS12960	COG0222	ribosome binding
HVS_RS12965	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HVS_RS12970	COG0081	regulation of translation
HVS_RS12975	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HVS_RS12980	COG0250	Participates in transcription elongation, termination and antitermination
HVS_RS12995	COG0028	Belongs to the TPP enzyme family
HVS_RS13000	COG0129	dihydroxy-acid dehydratase activity
HVS_RS13015	COG3464	Transposase
HVS_RS13020	COG3949	Membrane
HVS_RS13040	COG1131	(ABC) transporter
HVS_RS13045	COG0793	Belongs to the peptidase S41A family
HVS_RS13060	COG1395	domain, Protein
HVS_RS13065	COG0457	Tetratricopeptide repeat
HVS_RS13065	COG0705	Rhomboid family
HVS_RS13070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HVS_RS13075	COG3850	Histidine kinase
HVS_RS13075	COG5002	protein histidine kinase activity
HVS_RS13095	COG0840	transmembrane signaling receptor activity
HVS_RS13120	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVS_RS13200	COG0740	serine-type endopeptidase activity
HVS_RS13205	COG4695	Portal protein
HVS_RS13210	COG4626	Terminase
HVS_RS13210	COG1802	Transcriptional regulator
HVS_RS13310	COG1484	DNA-dependent DNA replication
HVS_RS13315	COG4584	PFAM Integrase catalytic
HVS_RS13380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HVS_RS13410	COG0438	transferase activity, transferring glycosyl groups
HVS_RS13445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HVS_RS13475	COG0514	ATP-dependent DNA helicase (RecQ)
HVS_RS13495	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVS_RS13515	COG5632	N-Acetylmuramoyl-L-alanine amidase
HVS_RS13515	COG3409	Peptidoglycan-binding domain 1 protein
HVS_RS13600	COG3464	Transposase
HVS_RS13630	COG1353	crispr-associated protein
HVS_RS13670	COG3708	Transcriptional regulator
HVS_RS13670	COG2207	Transcriptional regulator
HVS_RS13730	COG3328	transposase activity
HVS_RS13735	COG1028	Short-chain dehydrogenase reductase Sdr
HVS_RS13740	COG0583	DNA-binding transcription factor activity
HVS_RS13760	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HVS_RS13785	COG0535	radical SAM domain protein
HVS_RS13810	COG4447	cellulose binding
HVS_RS13815	COG0446	pyridine nucleotide-disulphide oxidoreductase
HVS_RS13860	COG0493	'glutamate synthase
HVS_RS13875	COG0697	spore germination
HVS_RS13880	COG2217	Heavy metal translocating P-type atpase
HVS_RS13890	COG0668	transmembrane transport
HVS_RS13900	COG0840	transmembrane signaling receptor activity
HVS_RS13905	COG1454	alcohol dehydrogenase
HVS_RS13905	COG1012	belongs to the aldehyde dehydrogenase family
HVS_RS13940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVS_RS13945	COG0601	transmembrane transport
HVS_RS13950	COG4166	transmembrane transport
HVS_RS13955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HVS_RS13965	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HVS_RS13965	COG2755	lipolytic protein G-D-S-L family
HVS_RS13970	COG0071	Belongs to the small heat shock protein (HSP20) family
HVS_RS13975	COG2244	polysaccharide biosynthetic process
HVS_RS13985	COG0297	glycogen (starch) synthase activity
HVS_RS13990	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HVS_RS14000	COG2337	Toxic component of a toxin-antitoxin (TA) module
HVS_RS14005	COG0864	Transcriptional regulator
HVS_RS14015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVS_RS14020	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HVS_RS14020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HVS_RS14045	COG0110	maltose O-acetyltransferase activity
HVS_RS14050	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HVS_RS14055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVS_RS14090	COG0714	Associated with various cellular activities
HVS_RS14105	COG2304	oxidoreductase activity
HVS_RS14125	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HVS_RS14145	COG1395	domain, Protein
HVS_RS14190	COG1151	hydroxylamine reductase activity
HVS_RS14200	COG1982	Orn Lys Arg decarboxylase major
HVS_RS14220	COG0504	CTP synthase activity
HVS_RS14225	COG3464	Transposase
HVS_RS14230	COG2340	Cysteine-rich secretory protein family
HVS_RS14235	COG0442	prolyl-tRNA aminoacylation
HVS_RS14250	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HVS_RS14265	COG4166	transmembrane transport
HVS_RS14275	COG0745	RESPONSE REGULATOR receiver
HVS_RS14305	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HVS_RS14310	COG1278	Cold shock
HVS_RS14320	COG5444	nuclease activity
HVS_RS14335	COG0739	heme binding
HVS_RS14340	COG2177	Part of the ABC transporter FtsEX involved in
HVS_RS14345	COG2884	Cell division ATP-binding protein ftsE
HVS_RS14355	COG3842	ATPase activity
HVS_RS14360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HVS_RS14365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HVS_RS14375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HVS_RS14380	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HVS_RS14390	COG4585	Histidine kinase
HVS_RS14395	COG2197	response regulator
HVS_RS14450	COG3459	Glycosyltransferase 36 associated
HVS_RS14460	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HVS_RS14465	COG3959	Transketolase, thiamine diphosphate binding domain
HVS_RS14470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HVS_RS14495	COG1607	acyl-coa hydrolase
HVS_RS14505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVS_RS14510	COG0681	Belongs to the peptidase S26 family
HVS_RS14530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HVS_RS14540	COG1063	alcohol dehydrogenase
HVS_RS14550	COG0826	peptidase U32
HVS_RS14560	COG5297	Belongs to the glycosyl hydrolase family 6
HVS_RS14575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HVS_RS14580	COG3584	3D domain protein
HVS_RS14580	COG3583	domain protein
HVS_RS14590	COG0084	hydrolase, TatD family'
HVS_RS14595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HVS_RS14595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HVS_RS14600	COG0700	Nucleoside recognition
HVS_RS14605	COG2715	membrane protein required for spore maturation
HVS_RS14610	COG2002	toxin-antitoxin pair type II binding
HVS_RS14615	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HVS_RS14620	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HVS_RS14630	COG1774	PSP1 C-terminal conserved region
HVS_RS14635	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HVS_RS14650	COG1982	Orn Lys Arg decarboxylase major
HVS_RS14660	COG0281	malic enzyme
HVS_RS14665	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HVS_RS14675	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HVS_RS14675	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HVS_RS14685	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HVS_RS14690	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVS_RS14695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HVS_RS14700	COG0248	Ppx GppA phosphatase
HVS_RS14705	COG3507	Belongs to the glycosyl hydrolase 43 family
HVS_RS14705	COG2382	esterase
HVS_RS14705	COG3693	PFAM glycoside hydrolase, family 10
HVS_RS14710	COG2133	pyrroloquinoline quinone binding
HVS_RS14710	COG5183	chlorophyll binding
HVS_RS14715	COG1191	sigma factor activity
HVS_RS14720	COG3464	Transposase
HVS_RS14730	COG1496	oxidoreductase activity
HVS_RS14750	COG0302	gtp cyclohydrolase
HVS_RS14760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HVS_RS14765	COG0473	3-isopropylmalate dehydrogenase activity
HVS_RS14770	COG1191	sigma factor activity
HVS_RS14790	COG3266	domain, Protein
HVS_RS14790	COG2911	Protein conserved in bacteria
HVS_RS14790	COG1361	Conserved repeat domain
HVS_RS14800	COG2207	Transcriptional regulator
HVS_RS14805	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HVS_RS14810	COG1073	alpha beta
HVS_RS14820	COG1516	flagellar protein fliS
HVS_RS14825	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HVS_RS14890	COG3464	Transposase
HVS_RS14900	COG4974	Belongs to the 'phage' integrase family
HVS_RS14905	COG0732	type I restriction modification DNA specificity domain
HVS_RS14940	COG4191	Histidine kinase
HVS_RS14945	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HVS_RS14955	COG1329	Transcriptional regulator
HVS_RS14960	COG0101	tRNA pseudouridine synthase activity
HVS_RS14965	COG1940	carbohydrate kinase activity
HVS_RS14970	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HVS_RS14975	COG1122	ATPase activity
HVS_RS14980	COG2813	Specifically methylates the guanine in position
HVS_RS14985	COG1122	ATPase activity
HVS_RS14990	COG0203	ribosomal protein L17
HVS_RS14995	COG0202	RNA polymerase activity
HVS_RS15000	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HVS_RS15005	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HVS_RS15010	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HVS_RS15015	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HVS_RS15020	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HVS_RS15035	COG0563	adenylate kinase activity
HVS_RS15040	COG0201	protein transport
HVS_RS15045	COG0200	Binds to the 23S rRNA
HVS_RS15050	COG1841	ribosomal large subunit assembly
HVS_RS15055	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HVS_RS15060	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HVS_RS15065	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HVS_RS15070	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HVS_RS15075	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HVS_RS15080	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HVS_RS15085	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HVS_RS15090	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HVS_RS15095	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HVS_RS15100	COG0255	Belongs to the universal ribosomal protein uL29 family
HVS_RS15105	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HVS_RS15110	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HVS_RS15115	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HVS_RS15120	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HVS_RS15125	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HVS_RS15130	COG0089	rRNA binding
HVS_RS15135	COG0088	Forms part of the polypeptide exit tunnel
HVS_RS15140	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HVS_RS15145	COG0051	transcription antitermination factor activity, RNA binding
HVS_RS15175	COG1191	sigma factor activity
HVS_RS15185	COG1366	Belongs to the anti-sigma-factor antagonist family
HVS_RS15190	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HVS_RS15195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVS_RS15200	COG3464	Transposase
HVS_RS15210	COG0516	GMP reductase activity
HVS_RS15210	COG0517	IMP dehydrogenase activity
HVS_RS15225	COG0459	protein refolding
HVS_RS15230	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HVS_RS15245	COG0107	imidazoleglycerol-phosphate synthase activity
HVS_RS15250	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HVS_RS15255	COG0131	Imidazoleglycerol-phosphate dehydratase
HVS_RS15260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HVS_RS15265	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HVS_RS15270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HVS_RS15275	COG0124	histidyl-tRNA synthetase
HVS_RS15280	COG5278	phosphoserine phosphatase activity
HVS_RS15280	COG0840	transmembrane signaling receptor activity
HVS_RS15285	COG0210	DNA helicase
HVS_RS15290	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVS_RS15300	COG1714	RDD family
HVS_RS15305	COG0616	signal peptide processing
HVS_RS15310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVS_RS15315	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HVS_RS15330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVS_RS15355	COG3464	Transposase
HVS_RS15365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVS_RS15370	COG4481	Protein conserved in bacteria
HVS_RS15385	COG0551	DNA topoisomerase type I activity
HVS_RS15385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVS_RS15395	COG2033	superoxide reductase activity
HVS_RS15400	COG3401	FG-GAP repeat protein
HVS_RS15405	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HVS_RS15410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HVS_RS15415	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HVS_RS15435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HVS_RS15470	COG0561	phosphatase activity
HVS_RS15485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HVS_RS15510	COG3546	catalase activity
HVS_RS15540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HVS_RS15550	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HVS_RS15555	COG0698	ribose 5-phosphate isomerase
HVS_RS15565	COG0009	L-threonylcarbamoyladenylate synthase
HVS_RS15575	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HVS_RS15590	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HVS_RS15615	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HVS_RS15625	COG2268	Band 7 protein
HVS_RS15640	COG3291	Pkd domain containing protein
HVS_RS15655	COG0655	NAD(P)H dehydrogenase (quinone) activity
HVS_RS15660	COG2755	lipolytic protein G-D-S-L family
HVS_RS15660	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HVS_RS15670	COG0653	protein targeting
HVS_RS15675	COG1368	sulfuric ester hydrolase activity
HVS_RS15680	COG1283	sodium-dependent phosphate transmembrane transporter activity
HVS_RS15695	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HVS_RS15705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVS_RS15715	COG0215	cysteine-tRNA ligase activity
HVS_RS15720	COG1045	serine acetyltransferase
HVS_RS15725	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HVS_RS15725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HVS_RS15770	COG2155	Conserved Protein
HVS_RS15775	COG0217	transcriptional regulatory protein
HVS_RS15780	COG4191	Histidine kinase
HVS_RS15780	COG2205	protein histidine kinase activity
HVS_RS15780	COG0745	RESPONSE REGULATOR receiver
HVS_RS15790	COG1739	Uncharacterized protein family UPF0029
HVS_RS15810	COG3250	beta-galactosidase activity
HVS_RS15820	COG1609	Transcriptional regulator
HVS_RS15830	COG2385	sporulation resulting in formation of a cellular spore
HVS_RS15935	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HVS_RS15940	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HVS_RS15945	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HVS_RS15965	COG5002	protein histidine kinase activity
HVS_RS15995	COG0517	IMP dehydrogenase activity
HVS_RS16010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HVS_RS16015	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HVS_RS16135	COG0726	polysaccharide deacetylase
HVS_RS16140	COG0840	transmembrane signaling receptor activity
HVS_RS16145	COG2207	Transcriptional regulator
HVS_RS16155	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVS_RS16160	COG0840	transmembrane signaling receptor activity
HVS_RS16165	COG1475	DNA binding
HVS_RS16170	COG0357	Ribosomal RNA small subunit methyltransferase G
HVS_RS16175	COG0445	tRNA wobble uridine modification
HVS_RS16180	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HVS_RS16185	COG1847	R3H domain protein
HVS_RS16200	COG0594	ribonuclease P activity
HVS_RS16205	COG0230	Belongs to the bacterial ribosomal protein bL34 family