locus-tag	class	description
FWK46_RS00015	COG0716	FMN binding
FWK46_RS00020	COG0445	tRNA wobble uridine modification
FWK46_RS00030	COG3312	ion transport
FWK46_RS00050	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FWK46_RS00060	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FWK46_RS00070	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FWK46_RS00075	COG0271	Belongs to the BolA IbaG family
FWK46_RS00095	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FWK46_RS00100	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FWK46_RS00105	COG2871	sodium ion transport
FWK46_RS00115	COG1477	protein flavinylation
FWK46_RS00120	COG2991	Protein conserved in bacteria
FWK46_RS00145	COG3005	denitrification pathway
FWK46_RS00150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FWK46_RS00155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FWK46_RS00170	COG1194	a g-specific adenine glycosylase
FWK46_RS00175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FWK46_RS00190	COG0471	metal ion transport
FWK46_RS00195	COG0583	DNA-binding transcription factor activity
FWK46_RS00200	COG3171	Protein conserved in bacteria
FWK46_RS00215	COG0762	integral membrane protein
FWK46_RS00230	COG2853	Lipoprotein
FWK46_RS00235	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FWK46_RS00245	COG0363	glucosamine-6-phosphate deaminase activity
FWK46_RS00250	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FWK46_RS00260	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FWK46_RS00295	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FWK46_RS00305	COG1187	pseudouridine synthase activity
FWK46_RS00315	COG2900	Belongs to the SlyX family
FWK46_RS00320	COG0545	Peptidyl-prolyl cis-trans isomerase
FWK46_RS00325	COG2964	Protein conserved in bacteria
FWK46_RS00335	COG2923	Belongs to the DsrF TusC family
FWK46_RS00355	COG5295	Hep Hag repeat protein
FWK46_RS00365	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
FWK46_RS00370	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FWK46_RS00400	COG3091	SprT-like family
FWK46_RS00415	COG0730	response to heat
FWK46_RS00430	COG0590	tRNA wobble adenosine to inosine editing
FWK46_RS00460	COG0859	PFAM glycosyl transferase family 9
FWK46_RS00470	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FWK46_RS00480	COG1763	Mo-molybdopterin cofactor biosynthetic process
FWK46_RS00485	COG3086	response to oxidative stress
FWK46_RS00490	COG3026	antisigma factor binding
FWK46_RS00495	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FWK46_RS00500	COG1595	DNA-templated transcription, initiation
FWK46_RS00510	COG0800	Aldolase
FWK46_RS00520	COG2211	Major facilitator Superfamily
FWK46_RS00535	COG1028	Short-chain dehydrogenase reductase Sdr
FWK46_RS00540	COG2186	Transcriptional regulator
FWK46_RS00560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FWK46_RS00565	COG0456	acetyltransferase
FWK46_RS00570	COG0149	triose-phosphate isomerase activity
FWK46_RS00575	COG1519	Transferase
FWK46_RS00585	COG1132	(ABC) transporter
FWK46_RS00590	COG3718	enzyme involved in inositol metabolism
FWK46_RS00600	COG0823	Involved in the tonB-independent uptake of proteins
FWK46_RS00610	COG0673	inositol 2-dehydrogenase activity
FWK46_RS00615	COG1879	ABC-type sugar transport system periplasmic component
FWK46_RS00620	COG1879	ABC-type sugar transport system periplasmic component
FWK46_RS00625	COG1129	ABC transporter
FWK46_RS00630	COG1172	Belongs to the binding-protein-dependent transport system permease family
FWK46_RS00645	COG0673	inositol 2-dehydrogenase activity
FWK46_RS00650	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FWK46_RS00655	COG0531	amino acid
FWK46_RS00660	COG1982	Orn Lys Arg decarboxylase major
FWK46_RS00670	COG0425	Belongs to the sulfur carrier protein TusA family
FWK46_RS00675	COG1739	Uncharacterized protein family UPF0029
FWK46_RS00680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FWK46_RS00735	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FWK46_RS00745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FWK46_RS00750	COG1737	Transcriptional regulator
FWK46_RS00755	COG1879	ABC-type sugar transport system periplasmic component
FWK46_RS00760	COG1129	ABC transporter
FWK46_RS00765	COG1172	Belongs to the binding-protein-dependent transport system permease family
FWK46_RS00770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FWK46_RS00775	COG1940	carbohydrate kinase activity
FWK46_RS00780	COG0698	ribose 5-phosphate isomerase
FWK46_RS00805	COG3068	Protein conserved in bacteria
FWK46_RS00815	COG1349	DNA-binding transcription factor activity
FWK46_RS00820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FWK46_RS00835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FWK46_RS00860	COG1929	Belongs to the glycerate kinase type-1 family
FWK46_RS00865	COG2610	gluconate transmembrane transporter activity
FWK46_RS00870	COG3835	regulator
FWK46_RS00895	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FWK46_RS00905	COG1447	Phosphotransferase system cellobiose-specific component IIA
FWK46_RS00910	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FWK46_RS00915	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FWK46_RS00920	COG1446	asparaginase
FWK46_RS00925	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FWK46_RS00935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FWK46_RS00945	COG0501	Belongs to the peptidase M48B family
FWK46_RS00955	COG0814	amino acid
FWK46_RS00960	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FWK46_RS00965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FWK46_RS00980	COG0495	leucyl-tRNA aminoacylation
FWK46_RS00985	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FWK46_RS00990	COG1466	dna polymerase III delta subunit
FWK46_RS00995	COG2884	Cell division ATP-binding protein ftsE
FWK46_RS01000	COG2177	Part of the ABC transporter FtsEX involved in
FWK46_RS01005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FWK46_RS01010	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FWK46_RS01015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FWK46_RS01020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FWK46_RS01025	COG1120	ATPase activity
FWK46_RS01040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FWK46_RS01050	COG3691	Protein conserved in bacteria
FWK46_RS01055	COG1741	Belongs to the pirin family
FWK46_RS01060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FWK46_RS01075	COG3850	Histidine kinase
FWK46_RS01080	COG3062	negative regulation of establishment of protein localization
FWK46_RS01085	COG0243	molybdopterin cofactor binding
FWK46_RS01090	COG0437	4 iron, 4 sulfur cluster binding
FWK46_RS01095	COG0348	domain, Protein
FWK46_RS01100	COG3043	anaerobic respiration
FWK46_RS01105	COG3005	denitrification pathway
FWK46_RS01110	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FWK46_RS01110	COG0047	phosphoribosylformylglycinamidine synthase activity
FWK46_RS01140	COG0475	glutathione-regulated potassium exporter activity
FWK46_RS01140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FWK46_RS01145	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FWK46_RS01160	COG2183	response to ionizing radiation
FWK46_RS01165	COG1114	Component of the transport system for branched-chain amino acids
FWK46_RS01175	COG1040	competence protein
FWK46_RS01185	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FWK46_RS01195	COG0470	DNA polymerase III
FWK46_RS01200	COG0084	hydrolase, TatD family'
FWK46_RS01210	COG1253	flavin adenine dinucleotide binding
FWK46_RS01225	COG1584	GPR1 FUN34 yaaH family protein
FWK46_RS01230	COG2814	Major facilitator Superfamily
FWK46_RS01250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FWK46_RS01255	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FWK46_RS01265	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FWK46_RS01315	COG4381	Mu-like prophage protein gp46
FWK46_RS01375	COG4397	Mu-like prophage major head subunit gpT
FWK46_RS01385	COG2369	cell adhesion
FWK46_RS01390	COG4383	Mu-like prophage protein gp29
FWK46_RS01430	COG3023	N-Acetylmuramoyl-L-alanine amidase
FWK46_RS01445	COG3561	AntA/AntB antirepressor
FWK46_RS01455	COG4382	Mu-like prophage protein Gp16
FWK46_RS01485	COG2842	Transposition protein
FWK46_RS01505	COG2801	Transposase and inactivated derivatives
FWK46_RS01520	COG4178	(ABC) transporter
FWK46_RS01525	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FWK46_RS01525	COG1328	CTP reductase activity
FWK46_RS01530	COG0602	queuosine metabolic process
FWK46_RS01535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FWK46_RS01550	COG0697	spore germination
FWK46_RS01555	COG4750	Nucleotidyl transferase
FWK46_RS01560	COG3475	LICD family
FWK46_RS01565	COG0194	GDP metabolic process
FWK46_RS01575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FWK46_RS01580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FWK46_RS01585	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FWK46_RS01615	COG0235	Class ii aldolase
FWK46_RS01625	COG1070	Carbohydrate kinase
FWK46_RS01630	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
FWK46_RS01640	COG1349	DNA-binding transcription factor activity
FWK46_RS01650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FWK46_RS01655	COG4942	peptidase
FWK46_RS01660	COG2861	carbohydrate metabolic process
FWK46_RS01665	COG1522	sequence-specific DNA binding
FWK46_RS01675	COG1285	pathogenesis
FWK46_RS01680	COG0360	Binds together with S18 to 16S ribosomal RNA
FWK46_RS01690	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FWK46_RS01700	COG1473	amidohydrolase
FWK46_RS01720	COG0387	Pfam Sodium calcium exchanger
FWK46_RS01730	COG1702	phosphate starvation-inducible protein PhoH
FWK46_RS01740	COG1444	tRNA N-acetyltransferase activity
FWK46_RS01745	COG1966	Carbon starvation protein
FWK46_RS01760	COG3116	cell division
FWK46_RS01765	COG0768	penicillin binding
FWK46_RS01770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FWK46_RS01775	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FWK46_RS01795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FWK46_RS01805	COG1181	Belongs to the D-alanine--D-alanine ligase family
FWK46_RS01810	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FWK46_RS01815	COG0849	cell division
FWK46_RS01820	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FWK46_RS01830	COG1605	Chorismate mutase
FWK46_RS01830	COG0077	Prephenate dehydratase
FWK46_RS01845	COG1496	oxidoreductase activity
FWK46_RS01850	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FWK46_RS01865	COG0488	(ABC) transporter
FWK46_RS01875	COG4172	Belongs to the ABC transporter superfamily
FWK46_RS01880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FWK46_RS01885	COG0601	transmembrane transport
FWK46_RS01895	COG4166	transmembrane transport
FWK46_RS01900	COG0569	domain protein
FWK46_RS01905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FWK46_RS01910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FWK46_RS01915	COG2610	gluconate transmembrane transporter activity
FWK46_RS01920	COG3265	gluconokinase activity
FWK46_RS01925	COG2358	TRAP transporter, solute receptor (TAXI family
FWK46_RS01955	COG2937	Belongs to the GPAT DAPAT family
FWK46_RS01995	COG4133	protoheme IX ABC transporter activity
FWK46_RS02000	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FWK46_RS02005	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FWK46_RS02010	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FWK46_RS02015	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FWK46_RS02020	COG1138	Cytochrome C-type biogenesis protein
FWK46_RS02040	COG2198	Histidine kinase
FWK46_RS02040	COG5002	protein histidine kinase activity
FWK46_RS02040	COG0784	Response regulator, receiver
FWK46_RS02045	COG1426	Protein conserved in bacteria
FWK46_RS02055	COG0124	histidyl-tRNA synthetase
FWK46_RS02060	COG2976	Protein conserved in bacteria
FWK46_RS02075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FWK46_RS02080	COG2860	membrane
FWK46_RS02095	COG0758	DNA mediated transformation
FWK46_RS02100	COG0742	ribosomal rna small subunit methyltransferase
FWK46_RS02105	COG0552	protein localization to endoplasmic reticulum
FWK46_RS02110	COG0728	peptidoglycan biosynthetic process
FWK46_RS02120	COG1217	gtp-binding protein TYPA
FWK46_RS02125	COG0174	glutamine synthetase
FWK46_RS02130	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FWK46_RS02130	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FWK46_RS02145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FWK46_RS02145	COG0519	Catalyzes the synthesis of GMP from XMP
FWK46_RS02215	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FWK46_RS02230	COG4783	chaperone-mediated protein folding
FWK46_RS02235	COG4783	chaperone-mediated protein folding
FWK46_RS02270	COG0326	Molecular chaperone. Has ATPase activity
FWK46_RS02280	COG0675	Transposase, IS605 OrfB family
FWK46_RS02290	COG2091	lysine biosynthetic process via aminoadipic acid
FWK46_RS02320	COG1459	type II secretion system
FWK46_RS02325	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FWK46_RS02335	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FWK46_RS02340	COG1115	amino acid carrier protein
FWK46_RS02345	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FWK46_RS02350	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FWK46_RS02360	COG0281	malic enzyme
FWK46_RS02360	COG0280	phosphate acetyltransferase
FWK46_RS02365	COG1027	Aspartate ammonia-lyase
FWK46_RS02385	COG3078	GTPase activator activity
FWK46_RS02395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FWK46_RS02410	COG0626	cystathionine gamma-synthase activity
FWK46_RS02415	COG0450	alkyl hydroperoxide reductase
FWK46_RS02445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FWK46_RS02450	COG1053	succinate dehydrogenase
FWK46_RS02465	COG0675	Transposase, IS605 OrfB family
FWK46_RS02470	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FWK46_RS02475	COG4608	Belongs to the ABC transporter superfamily
FWK46_RS02500	COG2350	Protein conserved in bacteria
FWK46_RS02505	COG1607	acyl-coa hydrolase
FWK46_RS02525	COG2927	DNA polymerase III (CHI subunit)
FWK46_RS02535	COG3177	Filamentation induced by cAMP protein fic
FWK46_RS02570	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FWK46_RS02575	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FWK46_RS02580	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FWK46_RS02585	COG1940	carbohydrate kinase activity
FWK46_RS02615	COG1172	Belongs to the binding-protein-dependent transport system permease family
FWK46_RS02625	COG0784	Response regulator, receiver
FWK46_RS02625	COG4191	Histidine kinase
FWK46_RS02635	COG0246	Mannitol dehydrogenase
FWK46_RS02640	COG3722	fumarate hydratase activity
FWK46_RS02645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FWK46_RS02655	COG1629	transport
FWK46_RS02655	COG4206	TonB-dependent receptor
FWK46_RS02665	COG3069	C4-dicarboxylate transmembrane transporter activity
FWK46_RS02670	COG1473	amidohydrolase
FWK46_RS02680	COG0681	Belongs to the peptidase S26 family
FWK46_RS02710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FWK46_RS02715	COG5295	Hep Hag repeat protein
FWK46_RS02715	COG5295	Hep Hag repeat protein
FWK46_RS02720	COG2095	MarC family integral membrane protein
FWK46_RS02730	COG4545	Glutaredoxin-related protein
FWK46_RS02805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FWK46_RS02830	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FWK46_RS02855	COG4383	Mu-like prophage protein gp29
FWK46_RS02860	COG1560	Kdo2-lipid A biosynthetic process
FWK46_RS02865	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FWK46_RS02865	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FWK46_RS02870	COG1393	Belongs to the ArsC family
FWK46_RS02880	COG1876	peptidase activity
FWK46_RS02885	COG0494	nUDIX hydrolase
FWK46_RS02890	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FWK46_RS02900	COG4214	carbohydrate transport
FWK46_RS02905	COG1129	ABC transporter
FWK46_RS02910	COG4213	ABC transporter substrate-binding protein
FWK46_RS02920	COG1070	Carbohydrate kinase
FWK46_RS02940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FWK46_RS02945	COG0328	RNA-DNA hybrid ribonuclease activity
FWK46_RS02950	COG1482	cell wall glycoprotein biosynthetic process
FWK46_RS02960	COG3716	PTS system mannose fructose sorbose family IID component
FWK46_RS02965	COG3715	PTS system
FWK46_RS02970	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FWK46_RS02970	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FWK46_RS02975	COG2926	Belongs to the UPF0265 family
FWK46_RS02980	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FWK46_RS02995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FWK46_RS03000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FWK46_RS03005	COG2267	carboxylic ester hydrolase activity
FWK46_RS03010	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FWK46_RS03020	COG0436	Aminotransferase
FWK46_RS03030	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FWK46_RS03040	COG1442	glycosyl transferase family 8
FWK46_RS03050	COG1215	transferase activity, transferring glycosyl groups
FWK46_RS03070	COG3842	ATPase activity
FWK46_RS03080	COG1840	ABC-type Fe3 transport system, periplasmic component
FWK46_RS03085	COG1840	ABC-type Fe3 transport system, periplasmic component
FWK46_RS03105	COG0385	Bile acid
FWK46_RS03125	COG0497	DNA recombination
FWK46_RS03135	COG0251	oxidation-reduction process
FWK46_RS03155	COG2835	tetraacyldisaccharide 4'-kinase activity
FWK46_RS03160	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FWK46_RS03165	COG0322	excinuclease ABC activity
FWK46_RS03170	COG2314	TM2 domain
FWK46_RS03180	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FWK46_RS03185	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FWK46_RS03195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FWK46_RS03200	COG0004	ammonium transporteR
FWK46_RS03215	COG1162	GTPase activity
FWK46_RS03220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FWK46_RS03225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FWK46_RS03230	COG2190	(PTS) system
FWK46_RS03235	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FWK46_RS03240	COG0508	dehydrogenase complex catalyzes the overall conversion of
FWK46_RS03245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FWK46_RS03250	COG2932	Transcriptional regulator
FWK46_RS03260	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
FWK46_RS03275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FWK46_RS03280	COG0469	pyruvate kinase activity
FWK46_RS03290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FWK46_RS03295	COG2833	Protein of unknown function (DUF455)
FWK46_RS03305	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FWK46_RS03310	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FWK46_RS03315	COG4988	ABC transporter
FWK46_RS03320	COG0492	ferredoxin-NADP+ reductase activity
FWK46_RS03325	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FWK46_RS03330	COG3219	Protein conserved in bacteria
FWK46_RS03335	COG3220	belongs to the UPF0276 family
FWK46_RS03345	COG2259	Doxx family
FWK46_RS03350	COG1882	Formate acetyltransferase
FWK46_RS03355	COG2116	formate transmembrane transporter activity
FWK46_RS03360	COG0537	adenosine 5'-monophosphoramidase activity
FWK46_RS03370	COG1472	Belongs to the glycosyl hydrolase 3 family
FWK46_RS03395	COG1077	Cell shape determining protein MreB Mrl
FWK46_RS03400	COG1792	Involved in formation and maintenance of cell shape
FWK46_RS03405	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FWK46_RS03410	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FWK46_RS03415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FWK46_RS03420	COG3956	TIGRFAM MazG family protein
FWK46_RS03450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FWK46_RS03460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FWK46_RS03465	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FWK46_RS03470	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FWK46_RS03485	COG4796	Type ii and iii secretion system protein
FWK46_RS03500	COG4972	Pilus assembly protein
FWK46_RS03505	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FWK46_RS03510	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FWK46_RS03515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FWK46_RS03525	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FWK46_RS03530	COG3283	Transcriptional regulator of aromatic amino acids metabolism
FWK46_RS03545	COG1476	TRANSCRIPTIONal
FWK46_RS03550	COG1605	Chorismate mutase
FWK46_RS03550	COG0287	Prephenate dehydrogenase
FWK46_RS03555	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FWK46_RS03560	COG1349	DNA-binding transcription factor activity
FWK46_RS03565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FWK46_RS03570	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
FWK46_RS03575	COG1028	Short-chain dehydrogenase reductase Sdr
FWK46_RS03590	COG3730	PTS system glucitol sorbitol-specific
FWK46_RS03615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FWK46_RS03620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FWK46_RS03625	COG0006	proline dipeptidase activity
FWK46_RS03645	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FWK46_RS03655	COG0560	Phosphoserine phosphatase
FWK46_RS03660	COG1666	GTP binding
FWK46_RS03670	COG0848	biopolymer transport protein
FWK46_RS03675	COG0811	peptide transport
FWK46_RS03680	COG0165	Argininosuccinate lyase
FWK46_RS03685	COG1295	ribonuclease BN
FWK46_RS03700	COG1737	Transcriptional regulator
FWK46_RS03705	COG2731	YhcH YjgK YiaL family protein
FWK46_RS03715	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FWK46_RS03725	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FWK46_RS03740	COG0513	Belongs to the DEAD box helicase family
FWK46_RS03750	COG1083	cytidylyl-transferase
FWK46_RS03755	COG1088	dTDP-glucose 4,6-dehydratase activity
FWK46_RS03760	COG1620	l-lactate permease
FWK46_RS03765	COG0247	lactate metabolic process
FWK46_RS03770	COG1139	Iron-sulfur cluster binding protein
FWK46_RS03775	COG1556	Lactate utilization protein
FWK46_RS03785	COG0745	RESPONSE REGULATOR receiver
FWK46_RS03795	COG1530	ribonuclease E activity
FWK46_RS03805	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FWK46_RS03805	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FWK46_RS03810	COG0210	DNA helicase
FWK46_RS03840	COG0748	coenzyme F420 binding
FWK46_RS03845	COG3721	Heme iron utilization protein
FWK46_RS03850	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FWK46_RS03855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FWK46_RS03860	COG3475	LICD family
FWK46_RS03865	COG1629	transport
FWK46_RS03870	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FWK46_RS03875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FWK46_RS03880	COG2062	phosphohistidine phosphatase, SixA
FWK46_RS03890	COG1199	ATP-dependent helicase activity
FWK46_RS03895	COG1214	PFAM Peptidase M22, glycoprotease
FWK46_RS03900	COG0318	PFAM AMP-dependent synthetase and ligase
FWK46_RS03905	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FWK46_RS03910	COG2823	Periplasmic or secreted lipoprotein
FWK46_RS03915	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FWK46_RS03920	COG0792	nuclease activity
FWK46_RS03935	COG0009	L-threonylcarbamoyladenylate synthase
FWK46_RS03950	COG1538	Outer membrane efflux protein
FWK46_RS03955	COG1349	DNA-binding transcription factor activity
FWK46_RS03965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FWK46_RS03970	COG0738	Major facilitator superfamily
FWK46_RS03980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FWK46_RS03995	COG2969	positive regulation of protein catabolic process
FWK46_RS04005	COG1940	carbohydrate kinase activity
FWK46_RS04010	COG1414	Transcriptional regulator
FWK46_RS04020	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FWK46_RS04025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FWK46_RS04030	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FWK46_RS04035	COG1129	ABC transporter
FWK46_RS04055	COG1879	ABC-type sugar transport system periplasmic component
FWK46_RS04060	COG1129	ABC transporter
FWK46_RS04065	COG1172	Belongs to the binding-protein-dependent transport system permease family
FWK46_RS04075	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FWK46_RS04080	COG3623	hexulose-6-phosphate isomerase
FWK46_RS04085	COG0235	Class ii aldolase
FWK46_RS04090	COG0561	phosphatase activity
FWK46_RS04095	COG2267	carboxylic ester hydrolase activity
FWK46_RS04110	COG0778	Nitroreductase
FWK46_RS04115	COG3691	Protein conserved in bacteria
FWK46_RS04120	COG0814	amino acid
FWK46_RS04125	COG3842	ATPase activity
FWK46_RS04135	COG1840	ABC-type Fe3 transport system, periplasmic component
FWK46_RS04140	COG0277	FAD linked oxidase domain protein
FWK46_RS04150	COG0788	formyltetrahydrofolate deformylase activity
FWK46_RS04160	COG1757	Na H antiporter
FWK46_RS04175	COG0339	signal peptide processing
FWK46_RS04180	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FWK46_RS04185	COG1757	Na H antiporter
FWK46_RS04190	COG1609	Transcriptional regulator
FWK46_RS04190	COG2207	Transcriptional regulator
FWK46_RS04200	COG4166	transmembrane transport
FWK46_RS04205	COG0488	(ABC) transporter
FWK46_RS04215	COG4172	Belongs to the ABC transporter superfamily
FWK46_RS04220	COG4172	Belongs to the ABC transporter superfamily
FWK46_RS04225	COG4171	peptide transport system, permease
FWK46_RS04230	COG4168	peptide transport system, permease
FWK46_RS04235	COG4166	transmembrane transport
FWK46_RS04240	COG3106	COG3106 Predicted ATPase
FWK46_RS04250	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FWK46_RS04255	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FWK46_RS04260	COG0187	DNA topoisomerase II activity
FWK46_RS04265	COG2814	Major facilitator Superfamily
FWK46_RS04270	COG2252	PERMEase
FWK46_RS04285	COG0814	amino acid
FWK46_RS04300	COG0857	belongs to the CobB CobQ family
FWK46_RS04300	COG0280	phosphate acetyltransferase
FWK46_RS04320	COG0243	molybdopterin cofactor binding
FWK46_RS04325	COG3005	denitrification pathway
FWK46_RS04350	COG0307	riboflavin synthase, alpha
FWK46_RS04355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FWK46_RS04360	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FWK46_RS04365	COG3105	Protein conserved in bacteria
FWK46_RS04370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FWK46_RS04375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FWK46_RS04380	COG0515	serine threonine protein kinase
FWK46_RS04390	COG0779	Required for maturation of 30S ribosomal subunits
FWK46_RS04395	COG0195	Participates in both transcription termination and antitermination
FWK46_RS04415	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FWK46_RS04420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FWK46_RS04425	COG3112	Uncharacterised protein family (UPF0231)
FWK46_RS04430	COG0316	Belongs to the HesB IscA family
FWK46_RS04435	COG0024	Methionine aminopeptidase
FWK46_RS04450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FWK46_RS04455	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FWK46_RS04460	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FWK46_RS04465	COG1280	lysine exporter protein (LysE YggA)
FWK46_RS04475	COG0708	Exodeoxyribonuclease III
FWK46_RS04480	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
FWK46_RS04485	COG1448	Aminotransferase
FWK46_RS04490	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FWK46_RS04495	COG0288	reversible hydration of carbon dioxide
FWK46_RS04510	COG0134	indole-3-glycerol-phosphate synthase activity
FWK46_RS04510	COG0135	phosphoribosylanthranilate isomerase activity
FWK46_RS04520	COG0512	Glutamine amidotransferase of anthranilate synthase
FWK46_RS04525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FWK46_RS04530	COG0616	signal peptide processing
FWK46_RS04545	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FWK46_RS04550	COG3118	belongs to the thioredoxin family
FWK46_RS04555	COG2252	PERMEase
FWK46_RS04560	COG3101	peptidyl-lysine hydroxylation
FWK46_RS04565	COG1131	(ABC) transporter
FWK46_RS04570	COG0842	Transport permease protein
FWK46_RS04575	COG1611	Belongs to the LOG family
FWK46_RS04580	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FWK46_RS04580	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FWK46_RS04585	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
FWK46_RS04590	COG3098	single-species biofilm formation
FWK46_RS04600	COG3140	Belongs to the UPF0181 family
FWK46_RS04605	COG1278	Cold shock
FWK46_RS04615	COG1067	ATP-dependent peptidase activity
FWK46_RS04640	COG0037	tRNA processing
FWK46_RS04645	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FWK46_RS04650	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FWK46_RS04660	COG3586	endonuclease activity
FWK46_RS04665	COG0697	spore germination
FWK46_RS04685	COG1943	Transposase
FWK46_RS04695	COG2925	Exonuclease
FWK46_RS04715	COG0586	Pfam SNARE associated Golgi protein
FWK46_RS04735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FWK46_RS04740	COG0589	response to stress
FWK46_RS04745	COG0285	dihydrofolate synthase activity
FWK46_RS04755	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FWK46_RS04760	COG0613	PHP domain protein
FWK46_RS04765	COG0308	aminopeptidase N
FWK46_RS04775	COG0297	glycogen (starch) synthase activity
FWK46_RS04785	COG1523	belongs to the glycosyl hydrolase 13 family
FWK46_RS04790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FWK46_RS04795	COG1640	4-alpha-glucanotransferase
FWK46_RS04805	COG0612	Peptidase, M16
FWK46_RS04810	COG4771	TonB-dependent receptor
FWK46_RS04850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FWK46_RS04850	COG0301	tRNA thio-modification
FWK46_RS04855	COG1722	exodeoxyribonuclease VII activity
FWK46_RS04860	COG0142	geranyltranstransferase activity
FWK46_RS04870	COG2431	L-lysine efflux transmembrane transporter activity
FWK46_RS04875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FWK46_RS04880	COG0616	signal peptide processing
FWK46_RS04885	COG0778	Nitroreductase
FWK46_RS04895	COG0303	'Molybdopterin
FWK46_RS04900	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FWK46_RS04905	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FWK46_RS04910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FWK46_RS04915	COG0163	prenyltransferase activity
FWK46_RS04925	COG1286	toxin biosynthetic process
FWK46_RS04935	COG0517	IMP dehydrogenase activity
FWK46_RS04935	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FWK46_RS04940	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FWK46_RS04945	COG1528	Iron-storage protein
FWK46_RS04950	COG1528	Iron-storage protein
FWK46_RS04955	COG1349	DNA-binding transcription factor activity
FWK46_RS04965	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FWK46_RS04970	COG0076	glutamate decarboxylase activity
FWK46_RS04975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FWK46_RS04980	COG1074	ATP-dependent DNA helicase activity
FWK46_RS04990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FWK46_RS04995	COG0825	malonyl-CoA metabolic process
FWK46_RS05020	COG0305	Participates in initiation and elongation during chromosome replication
FWK46_RS05025	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FWK46_RS05030	COG4591	ABC-type transport system involved in lipoprotein release permease component
FWK46_RS05035	COG1136	(ABC) transporter
FWK46_RS05040	COG4591	ABC-type transport system involved in lipoprotein release permease component
FWK46_RS05045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FWK46_RS05065	COG1714	RDD family
FWK46_RS05080	COG3133	Outer membrane lipoprotein
FWK46_RS05090	COG3102	Protein conserved in bacteria
FWK46_RS05100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FWK46_RS05110	COG0508	dehydrogenase complex catalyzes the overall conversion of
FWK46_RS05115	COG0567	Dehydrogenase, E1 component
FWK46_RS05125	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FWK46_RS05130	COG0633	Ferredoxin
FWK46_RS05135	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FWK46_RS05140	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FWK46_RS05145	COG1346	cytolysis
FWK46_RS05150	COG1380	Effector of murein hydrolase LrgA
FWK46_RS05155	COG1525	nuclease
FWK46_RS05165	COG2166	iron-sulfur cluster assembly
FWK46_RS05175	COG3077	Addiction module antitoxin, RelB DinJ family
FWK46_RS05180	COG3041	Addiction module toxin RelE StbE family
FWK46_RS05195	COG4453	Protein conserved in bacteria
FWK46_RS05205	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FWK46_RS05210	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FWK46_RS05220	COG0539	negative regulation of cytoplasmic translation
FWK46_RS05225	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FWK46_RS05230	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FWK46_RS05245	COG0750	zinc metalloprotease
FWK46_RS05250	COG0575	Belongs to the CDS family
FWK46_RS05260	COG5413	integral membrane protein
FWK46_RS05265	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FWK46_RS05275	COG0528	UMP kinase activity
FWK46_RS05290	COG0653	protein targeting
FWK46_RS05295	COG0494	nUDIX hydrolase
FWK46_RS05300	COG1643	Atp-dependent helicase
FWK46_RS05305	COG2707	UPF0756 membrane protein
FWK46_RS05325	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FWK46_RS05330	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FWK46_RS05345	COG1534	Rna-binding protein
FWK46_RS05350	COG1393	Belongs to the ArsC family
FWK46_RS05365	COG5295	Hep Hag repeat protein
FWK46_RS05370	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FWK46_RS05375	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FWK46_RS05380	COG1178	ABC-type Fe3 transport system permease component
FWK46_RS05385	COG4143	(ABC) transporter
FWK46_RS05400	COG2056	Na+-H+ antiporter family
FWK46_RS05415	COG1595	DNA-templated transcription, initiation
FWK46_RS05460	COG1132	(ABC) transporter
FWK46_RS05465	COG2333	competence protein COMEC
FWK46_RS05465	COG0658	competence protein
FWK46_RS05470	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FWK46_RS05475	COG0617	tRNA 3'-terminal CCA addition
FWK46_RS05480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FWK46_RS05485	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FWK46_RS05495	COG0314	molybdopterin synthase activity
FWK46_RS05500	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FWK46_RS05505	COG0315	cyclic pyranopterin monophosphate synthase activity
FWK46_RS05510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FWK46_RS05515	COG1609	Transcriptional regulator
FWK46_RS05520	COG0583	DNA-binding transcription factor activity
FWK46_RS05535	COG0739	heme binding
FWK46_RS05540	COG1121	(ABC) transporter
FWK46_RS05545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FWK46_RS05550	COG1115	amino acid carrier protein
FWK46_RS05555	COG1940	carbohydrate kinase activity
FWK46_RS05560	COG0671	phosphoesterase, PA-phosphatase related
FWK46_RS05570	COG0247	lactate metabolic process
FWK46_RS05570	COG0277	FAD linked oxidase domain protein
FWK46_RS05590	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FWK46_RS05595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FWK46_RS05600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FWK46_RS05600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FWK46_RS05610	COG1687	branched-chain amino acid
FWK46_RS05615	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FWK46_RS05620	COG0583	DNA-binding transcription factor activity
FWK46_RS05630	COG1438	arginine binding
FWK46_RS05635	COG1090	epimerase
FWK46_RS05640	COG5295	Hep Hag repeat protein
FWK46_RS05655	COG4656	Part of a membrane complex involved in electron transport
FWK46_RS05660	COG4658	electron transport chain
FWK46_RS05675	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FWK46_RS05680	COG0733	neurotransmitter:sodium symporter activity
FWK46_RS05695	COG3008	intermembrane lipid transfer
FWK46_RS05700	COG2995	paraquat-inducible protein a
FWK46_RS05705	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
FWK46_RS05710	COG0793	Belongs to the peptidase S41A family
FWK46_RS05715	COG2989	Protein conserved in bacteria
FWK46_RS05720	COG3108	Peptidase M15
FWK46_RS05725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FWK46_RS05740	COG2949	membrane
FWK46_RS05755	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
FWK46_RS05760	COG3683	transport system, periplasmic component
FWK46_RS05765	COG0802	atpase or kinase
FWK46_RS05770	COG0860	N-Acetylmuramoyl-L-alanine amidase
FWK46_RS05770	COG1388	LysM domain
FWK46_RS05775	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FWK46_RS05785	COG5295	Hep Hag repeat protein
FWK46_RS05795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FWK46_RS05800	COG3842	ATPase activity
FWK46_RS05805	COG1176	ABC-type spermidine putrescine transport system, permease component I
FWK46_RS05810	COG1177	transmembrane transport
FWK46_RS05815	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FWK46_RS05820	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FWK46_RS05830	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FWK46_RS05840	COG2824	Alkylphosphonate utilization operon protein PhnA
FWK46_RS05845	COG0814	amino acid
FWK46_RS05850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FWK46_RS05855	COG5007	Belongs to the BolA IbaG family
FWK46_RS05860	COG3113	response to antibiotic
FWK46_RS05865	COG2854	intermembrane phospholipid transfer
FWK46_RS05870	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FWK46_RS05875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FWK46_RS05880	COG1127	ABC transporter
FWK46_RS05885	COG3117	lipopolysaccharide transmembrane transporter activity
FWK46_RS05890	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FWK46_RS05895	COG1137	ATPase activity
FWK46_RS05900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FWK46_RS05910	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FWK46_RS05910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FWK46_RS05915	COG0489	protein tyrosine kinase activity
FWK46_RS05925	COG3041	Addiction module toxin RelE StbE family
FWK46_RS05930	COG3077	Addiction module antitoxin, RelB DinJ family
FWK46_RS05935	COG3381	protein complex oligomerization
FWK46_RS05940	COG2249	NAD(P)H dehydrogenase (quinone) activity
FWK46_RS05950	COG0330	HflC and HflK could
FWK46_RS05960	COG0511	ligase activity, forming carbon-carbon bonds
FWK46_RS05965	COG0439	Biotin carboxylase
FWK46_RS05970	COG3924	membrane
FWK46_RS05975	COG4145	pantothenate transmembrane transporter activity
FWK46_RS06015	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FWK46_RS06030	COG2184	nucleotidyltransferase activity
FWK46_RS06040	COG0732	type I restriction modification DNA specificity domain
FWK46_RS06060	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FWK46_RS06065	COG0504	CTP synthase activity
FWK46_RS06080	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FWK46_RS06090	COG0805	protein transport
FWK46_RS06095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FWK46_RS06105	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FWK46_RS06120	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FWK46_RS06130	COG3210	domain, Protein
FWK46_RS06185	COG2732	(Barnase) inhibitor
FWK46_RS06295	COG0795	lipopolysaccharide-transporting ATPase activity
FWK46_RS06300	COG0795	lipopolysaccharide-transporting ATPase activity
FWK46_RS06310	COG1349	DNA-binding transcription factor activity
FWK46_RS06315	COG0247	lactate metabolic process
FWK46_RS06325	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FWK46_RS06330	COG2271	Major facilitator Superfamily
FWK46_RS06335	COG0584	glycerophosphoryl diester phosphodiesterase
FWK46_RS06340	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FWK46_RS06350	COG0494	nUDIX hydrolase
FWK46_RS06360	COG2867	negative regulation of translational initiation
FWK46_RS06365	COG0193	aminoacyl-tRNA hydrolase activity
FWK46_RS06370	COG0012	GTP binding
FWK46_RS06375	COG0346	lactoylglutathione lyase activity
FWK46_RS06380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FWK46_RS06390	COG0204	Acyl-transferase
FWK46_RS06395	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FWK46_RS06400	COG0210	DNA helicase
FWK46_RS06410	COG0583	DNA-binding transcription factor activity
FWK46_RS06415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FWK46_RS06420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FWK46_RS06425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FWK46_RS06435	COG0456	acetyltransferase
FWK46_RS06440	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
FWK46_RS06445	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FWK46_RS06450	COG0330	HflC and HflK could
FWK46_RS06455	COG0330	HflC and HflK could
FWK46_RS06485	COG0675	Transposase, IS605 OrfB family
FWK46_RS06510	COG0751	glycine-tRNA ligase activity
FWK46_RS06525	COG1522	sequence-specific DNA binding
FWK46_RS06530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FWK46_RS06535	COG3025	triphosphatase activity
FWK46_RS06540	COG1392	Phosphate transport regulator
FWK46_RS06545	COG0306	phosphate transporter
FWK46_RS06550	COG4991	sh3 domain protein
FWK46_RS06555	COG0617	tRNA 3'-terminal CCA addition
FWK46_RS06565	COG0484	heat shock protein binding
FWK46_RS06580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FWK46_RS06585	COG3063	Type IV pilus biogenesis stability protein PilW
FWK46_RS06595	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FWK46_RS06605	COG1560	Kdo2-lipid A biosynthetic process
FWK46_RS06610	COG0730	response to heat
FWK46_RS06615	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
FWK46_RS06625	COG3264	Mechanosensitive ion channel
FWK46_RS06625	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FWK46_RS06630	COG0318	PFAM AMP-dependent synthetase and ligase
FWK46_RS06635	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FWK46_RS06640	COG0596	Alpha beta hydrolase
FWK46_RS06650	COG0716	FMN binding
FWK46_RS06655	COG0735	belongs to the Fur family
FWK46_RS06660	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FWK46_RS06665	COG0083	homoserine kinase activity
FWK46_RS06670	COG0460	homoserine dehydrogenase
FWK46_RS06670	COG0527	aspartate kinase activity
FWK46_RS06680	COG1570	exodeoxyribonuclease VII activity
FWK46_RS06700	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FWK46_RS06705	COG4149	molybdate abc transporter
FWK46_RS06710	COG0725	ABC transporter, periplasmic molybdate-binding protein
FWK46_RS06730	COG5295	Hep Hag repeat protein
FWK46_RS06745	COG4974	Belongs to the 'phage' integrase family
FWK46_RS06750	COG2814	Major facilitator Superfamily
FWK46_RS06755	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FWK46_RS06765	COG3061	Opacity-associated protein A
FWK46_RS06765	COG3266	domain, Protein
FWK46_RS06770	COG1509	lysine 2,3-aminomutase activity
FWK46_RS06795	COG1561	YicC-like family, N-terminal region
FWK46_RS06800	COG0354	folic acid binding
FWK46_RS06805	COG0513	Belongs to the DEAD box helicase family
FWK46_RS06810	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FWK46_RS06815	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FWK46_RS06820	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FWK46_RS06835	COG0545	Peptidyl-prolyl cis-trans isomerase
FWK46_RS06840	COG0488	(ABC) transporter
FWK46_RS06855	COG0442	prolyl-tRNA aminoacylation
FWK46_RS06885	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FWK46_RS06895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FWK46_RS06900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FWK46_RS06905	COG1862	Preprotein translocase
FWK46_RS06910	COG0343	queuine tRNA-ribosyltransferase activity
FWK46_RS06920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FWK46_RS06925	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FWK46_RS06925	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FWK46_RS06930	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FWK46_RS06940	COG0826	peptidase U32
FWK46_RS06945	COG1793	dna ligase
FWK46_RS06955	COG3028	Belongs to the UPF0307 family
FWK46_RS06960	COG0312	modulator of DNA gyrase
FWK46_RS06965	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FWK46_RS06975	COG3250	beta-galactosidase activity
FWK46_RS06990	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FWK46_RS07010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FWK46_RS07020	COG0626	cystathionine gamma-synthase activity
FWK46_RS07115	COG1484	DNA-dependent DNA replication
FWK46_RS07120	COG0582	viral genome integration into host DNA
FWK46_RS07175	COG1476	TRANSCRIPTIONal
FWK46_RS07190	COG3152	Membrane
FWK46_RS07200	COG3621	Patatin-like phospholipase
FWK46_RS07290	COG0675	Transposase, IS605 OrfB family
FWK46_RS07335	COG4453	Protein conserved in bacteria
FWK46_RS07345	COG3210	domain, Protein
FWK46_RS07395	COG3210	domain, Protein
FWK46_RS07395	COG3210	domain, Protein
FWK46_RS07400	COG2831	hemolysin activation secretion protein
FWK46_RS07405	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FWK46_RS07410	COG1803	Methylglyoxal synthase
FWK46_RS07415	COG1289	transmembrane transporter activity
FWK46_RS07425	COG2890	protein-(glutamine-N5) methyltransferase activity
FWK46_RS07430	COG0628	permease
FWK46_RS07440	COG0521	Mo-molybdopterin cofactor biosynthetic process
FWK46_RS07445	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FWK46_RS07465	COG2990	Protein conserved in bacteria
FWK46_RS07470	COG0137	argininosuccinate synthase activity
FWK46_RS07475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FWK46_RS07605	COG0675	Transposase, IS605 OrfB family
FWK46_RS07760	COG3723	Recombinational DNA repair protein, rece pathway
FWK46_RS07785	COG0202	RNA polymerase activity
FWK46_RS07795	COG0582	viral genome integration into host DNA
FWK46_RS07805	COG0659	secondary active sulfate transmembrane transporter activity
FWK46_RS07810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FWK46_RS07815	COG4137	Cytochrome C assembly protein
FWK46_RS07820	COG4536	flavin adenine dinucleotide binding
FWK46_RS07825	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FWK46_RS07840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FWK46_RS07850	COG0248	Ppx GppA phosphatase
FWK46_RS07855	COG2911	Protein conserved in bacteria
FWK46_RS07860	COG0729	surface antigen
FWK46_RS07865	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FWK46_RS07895	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FWK46_RS07900	COG0606	chelatase, subunit chli
FWK46_RS07915	COG2920	part of a sulfur-relay system
FWK46_RS07925	COG1121	(ABC) transporter
FWK46_RS07930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FWK46_RS07935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FWK46_RS07940	COG0799	negative regulation of ribosome biogenesis
FWK46_RS07950	COG0768	penicillin binding
FWK46_RS07955	COG0772	Belongs to the SEDS family
FWK46_RS07965	COG1686	Belongs to the peptidase S11 family
FWK46_RS07995	COG1297	OPT oligopeptide transporter protein
FWK46_RS08000	COG0746	molybdenum cofactor guanylyltransferase activity
FWK46_RS08005	COG3084	Protein conserved in bacteria
FWK46_RS08010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FWK46_RS08015	COG3085	chromosome segregation
FWK46_RS08035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FWK46_RS08045	COG2176	DNA-directed DNA polymerase activity
FWK46_RS08050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FWK46_RS08055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FWK46_RS08060	COG1609	Transcriptional regulator
FWK46_RS08080	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FWK46_RS08085	COG0228	four-way junction DNA binding
FWK46_RS08095	COG2364	Membrane
FWK46_RS08100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FWK46_RS08105	COG0813	purine-nucleoside phosphorylase activity
FWK46_RS08110	COG1181	Belongs to the D-alanine--D-alanine ligase family
FWK46_RS08110	COG2918	glutathione biosynthetic process
FWK46_RS08115	COG0633	Ferredoxin
FWK46_RS08120	COG0443	Heat shock 70 kDa protein
FWK46_RS08125	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FWK46_RS08135	COG0822	iron-sulfur transferase activity
FWK46_RS08145	COG1959	2 iron, 2 sulfur cluster binding
FWK46_RS08150	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FWK46_RS08160	COG4797	methyltransferase
FWK46_RS08160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FWK46_RS08175	COG1530	ribonuclease E activity
FWK46_RS08180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FWK46_RS08190	COG2081	HI0933 family
FWK46_RS08205	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FWK46_RS08220	COG4795	General secretion pathway protein
FWK46_RS08225	COG2165	general secretion pathway protein
FWK46_RS08255	COG3064	Membrane
FWK46_RS08260	COG0848	biopolymer transport protein
FWK46_RS08265	COG0811	peptide transport
FWK46_RS08270	COG0824	Thioesterase
FWK46_RS08280	COG1294	oxidase, subunit
FWK46_RS08285	COG1271	oxidase subunit
FWK46_RS08295	COG4160	amino acid transport
FWK46_RS08300	COG4215	(ABC) transporter
FWK46_RS08305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FWK46_RS08310	COG1126	abc transporter atp-binding protein
FWK46_RS08315	COG4969	Belongs to the N-Me-Phe pilin family
FWK46_RS08320	COG3023	N-Acetylmuramoyl-L-alanine amidase
FWK46_RS08325	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FWK46_RS08330	COG0697	spore germination
FWK46_RS08345	COG0142	geranyltranstransferase activity
FWK46_RS08350	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FWK46_RS08355	COG0215	cysteine-tRNA ligase activity
FWK46_RS08360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FWK46_RS08365	COG0084	hydrolase, TatD family'
FWK46_RS08380	COG2017	converts alpha-aldose to the beta-anomer
FWK46_RS08385	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FWK46_RS08390	COG1085	galactose-1-phosphate uridylyltransferase
FWK46_RS08395	COG1609	Transcriptional regulator
FWK46_RS08400	COG1879	ABC-type sugar transport system periplasmic component
FWK46_RS08405	COG1129	ABC transporter
FWK46_RS08410	COG4211	Belongs to the binding-protein-dependent transport system permease family
FWK46_RS08415	COG1368	sulfuric ester hydrolase activity
FWK46_RS08420	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FWK46_RS08425	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FWK46_RS08430	COG1489	DNA binding
FWK46_RS08435	COG3083	sulfuric ester hydrolase activity
FWK46_RS08445	COG3081	Nucleoid-associated protein
FWK46_RS08450	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FWK46_RS08460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FWK46_RS08465	COG1879	ABC-type sugar transport system periplasmic component
FWK46_RS08470	COG1172	Belongs to the binding-protein-dependent transport system permease family
FWK46_RS08475	COG1129	ABC transporter
FWK46_RS08485	COG1720	tRNA m6t6A37 methyltransferase activity
FWK46_RS08490	COG1575	Belongs to the MenA family. Type 1 subfamily
FWK46_RS08495	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FWK46_RS08500	COG0471	metal ion transport
FWK46_RS08505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FWK46_RS08510	COG0765	amino acid transport
FWK46_RS08515	COG1126	abc transporter atp-binding protein
FWK46_RS08525	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FWK46_RS08535	COG0191	fructose-bisphosphate aldolase activity
FWK46_RS08540	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FWK46_RS08550	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FWK46_RS08580	COG0786	glutamate:sodium symporter activity
FWK46_RS08615	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FWK46_RS08625	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FWK46_RS08630	COG2966	Psort location CytoplasmicMembrane, score
FWK46_RS08635	COG3610	response to peptide
FWK46_RS08640	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FWK46_RS08645	COG0196	riboflavin kinase activity
FWK46_RS08655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FWK46_RS08665	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FWK46_RS08680	COG2860	membrane
FWK46_RS08695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FWK46_RS08715	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FWK46_RS08725	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FWK46_RS08740	COG0081	regulation of translation
FWK46_RS08755	COG1028	Short-chain dehydrogenase reductase Sdr
FWK46_RS08760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FWK46_RS08765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FWK46_RS08770	COG0416	fatty acid biosynthetic process
FWK46_RS08780	COG1399	metal-binding, possibly nucleic acid-binding protein
FWK46_RS08785	COG0705	Rhomboid family
FWK46_RS08800	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FWK46_RS08805	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FWK46_RS08810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FWK46_RS08815	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FWK46_RS08825	COG1045	serine acetyltransferase
FWK46_RS08840	COG0557	exoribonuclease II activity
FWK46_RS08845	COG3161	chorismate lyase activity
FWK46_RS08850	COG2258	MOSC domain
FWK46_RS08855	COG3978	acetolactate synthase activity
FWK46_RS08865	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FWK46_RS08885	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FWK46_RS08910	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FWK46_RS08915	COG0592	DNA-directed DNA polymerase activity
FWK46_RS08920	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FWK46_RS08940	COG0706	membrane insertase activity
FWK46_RS08950	COG0783	Belongs to the Dps family
FWK46_RS08955	COG0512	Glutamine amidotransferase of anthranilate synthase
FWK46_RS08960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FWK46_RS08965	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FWK46_RS08970	COG0251	oxidation-reduction process
FWK46_RS08975	COG1555	photosystem II stabilization
FWK46_RS08980	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FWK46_RS08985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FWK46_RS08990	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FWK46_RS08995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FWK46_RS09045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FWK46_RS09050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FWK46_RS09065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FWK46_RS09070	COG1028	Short-chain dehydrogenase reductase Sdr
FWK46_RS09080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FWK46_RS09095	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FWK46_RS09100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FWK46_RS09105	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FWK46_RS09110	COG1381	Involved in DNA repair and RecF pathway recombination
FWK46_RS09125	COG3172	ATPase kinase involved in NAD metabolism
FWK46_RS09130	COG2129	metallophosphoesterase
FWK46_RS09140	COG0202	RNA polymerase activity
FWK46_RS09155	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FWK46_RS09165	COG0201	protein transport
FWK46_RS09175	COG1841	ribosomal large subunit assembly
FWK46_RS09240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FWK46_RS09245	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FWK46_RS09250	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FWK46_RS09260	COG0089	rRNA binding
FWK46_RS09275	COG0051	transcription antitermination factor activity, RNA binding
FWK46_RS09310	COG1129	ABC transporter
FWK46_RS09315	COG2390	Transcriptional regulator
FWK46_RS09320	COG1070	Carbohydrate kinase
FWK46_RS09330	COG3071	HemY protein
FWK46_RS09335	COG2959	enzyme of heme biosynthesis
FWK46_RS09355	COG2197	response regulator
FWK46_RS09360	COG0242	peptide deformylase activity
FWK46_RS09365	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FWK46_RS09375	COG0569	domain protein
FWK46_RS09385	COG0583	DNA-binding transcription factor activity
FWK46_RS09390	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FWK46_RS09390	COG0678	peroxiredoxin activity
FWK46_RS09400	COG1172	Belongs to the binding-protein-dependent transport system permease family
FWK46_RS09405	COG1172	Belongs to the binding-protein-dependent transport system permease family
FWK46_RS09425	COG1914	H( )-stimulated, divalent metal cation uptake system
FWK46_RS09430	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FWK46_RS09435	COG1984	allophanate hydrolase subunit 2
FWK46_RS09440	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FWK46_RS09445	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FWK46_RS09450	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FWK46_RS09455	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FWK46_RS09460	COG1063	alcohol dehydrogenase
FWK46_RS09465	COG2186	Transcriptional regulator
FWK46_RS09485	COG2610	gluconate transmembrane transporter activity
FWK46_RS09490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FWK46_RS09495	COG3622	Belongs to the hyi family
FWK46_RS09500	COG0235	Class ii aldolase
FWK46_RS09505	COG3395	kinase activity
FWK46_RS09510	COG2084	Dehydrogenase
FWK46_RS09515	COG1349	DNA-binding transcription factor activity
FWK46_RS09530	COG0551	DNA topoisomerase type I activity
FWK46_RS09535	COG0009	L-threonylcarbamoyladenylate synthase
FWK46_RS09550	COG2195	Cleaves the N-terminal amino acid of tripeptides
FWK46_RS09575	COG3048	D-serine ammonia-lyase activity
FWK46_RS09580	COG2610	gluconate transmembrane transporter activity
FWK46_RS09585	COG0583	DNA-binding transcription factor activity
FWK46_RS09615	COG3070	regulator of competence-specific genes
FWK46_RS09625	COG0733	neurotransmitter:sodium symporter activity
FWK46_RS09630	COG0019	diaminopimelate decarboxylase activity
FWK46_RS09640	COG1965	Belongs to the frataxin family