locus-tag	class	description
A4V00_RS00025	COG0335	large ribosomal subunit rRNA binding
A4V00_RS00040	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A4V00_RS00045	COG0792	nuclease activity
A4V00_RS00065	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4V00_RS00075	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A4V00_RS00080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4V00_RS00085	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A4V00_RS00090	COG0019	diaminopimelate decarboxylase activity
A4V00_RS00095	COG4496	protein, YerC YecD
A4V00_RS00100	COG2226	methyltransferase
A4V00_RS00105	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A4V00_RS00135	COG0519	Catalyzes the synthesis of GMP from XMP
A4V00_RS00145	COG0646	methionine synthase
A4V00_RS00145	COG1410	methionine synthase
A4V00_RS00155	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A4V00_RS00160	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4V00_RS00165	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A4V00_RS00175	COG4974	Belongs to the 'phage' integrase family
A4V00_RS00215	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A4V00_RS00220	COG0534	Mate efflux family protein
A4V00_RS00225	COG4106	trans-aconitate 2-methyltransferase activity
A4V00_RS00230	COG0484	heat shock protein binding
A4V00_RS00235	COG0443	Heat shock 70 kDa protein
A4V00_RS00240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4V00_RS00245	COG1420	regulation of RNA biosynthetic process
A4V00_RS00270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4V00_RS00285	COG0395	ABC-type sugar transport system, permease component
A4V00_RS00290	COG4209	transmembrane transport
A4V00_RS00300	COG2207	Transcriptional regulator
A4V00_RS00305	COG3250	beta-galactosidase activity
A4V00_RS00310	COG1917	Cupin 2, conserved barrel domain protein
A4V00_RS00310	COG2207	Transcriptional regulator
A4V00_RS00320	COG2207	Transcriptional regulator
A4V00_RS00325	COG4209	transmembrane transport
A4V00_RS00330	COG0395	ABC-type sugar transport system, permease component
A4V00_RS00350	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4V00_RS00355	COG1882	Formate acetyltransferase
A4V00_RS00375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A4V00_RS00380	COG2384	SAM-dependent methyltransferase
A4V00_RS00390	COG1191	sigma factor activity
A4V00_RS00415	COG0784	Response regulator, receiver
A4V00_RS00415	COG2205	protein histidine kinase activity
A4V00_RS00415	COG5002	protein histidine kinase activity
A4V00_RS00455	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A4V00_RS00460	COG1876	peptidase activity
A4V00_RS00465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4V00_RS00470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4V00_RS00475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V00_RS00480	COG0110	maltose O-acetyltransferase activity
A4V00_RS00490	COG2017	converts alpha-aldose to the beta-anomer
A4V00_RS00495	COG1940	carbohydrate kinase activity
A4V00_RS00505	COG0534	Mate efflux family protein
A4V00_RS00510	COG0514	ATP-dependent DNA helicase (RecQ)
A4V00_RS00520	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A4V00_RS00535	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4V00_RS00540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4V00_RS00545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A4V00_RS00555	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A4V00_RS00565	COG0165	Argininosuccinate lyase
A4V00_RS00585	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4V00_RS00595	COG1131	(ABC) transporter
A4V00_RS00615	COG1013	pyruvate-flavodoxin oxidoreductase activity
A4V00_RS00615	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4V00_RS00615	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4V00_RS00615	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A4V00_RS00630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4V00_RS00645	COG1051	belongs to the nudix hydrolase family
A4V00_RS00670	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A4V00_RS00675	COG0205	6-phosphofructokinase activity
A4V00_RS00695	COG0673	inositol 2-dehydrogenase activity
A4V00_RS00705	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A4V00_RS00710	COG0457	Tetratricopeptide repeat
A4V00_RS00710	COG0463	Glycosyl transferase, family 2
A4V00_RS00760	COG1132	(ABC) transporter
A4V00_RS00765	COG1757	Na H antiporter
A4V00_RS00770	COG2226	methyltransferase
A4V00_RS00805	COG0745	RESPONSE REGULATOR receiver
A4V00_RS00810	COG5002	protein histidine kinase activity
A4V00_RS00835	COG4869	propanediol catabolic process
A4V00_RS00840	COG1573	uracil-dna glycosylase
A4V00_RS00845	COG0406	alpha-ribazole phosphatase activity
A4V00_RS00855	COG1077	Cell shape determining protein MreB Mrl
A4V00_RS00890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4V00_RS00895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4V00_RS00925	COG0395	ABC-type sugar transport system, permease component
A4V00_RS00940	COG0395	ABC-type sugar transport system, permease component
A4V00_RS00945	COG4209	transmembrane transport
A4V00_RS00980	COG0395	ABC-type sugar transport system, permease component
A4V00_RS00985	COG4209	transmembrane transport
A4V00_RS00990	COG2207	Transcriptional regulator
A4V00_RS00995	COG1012	belongs to the aldehyde dehydrogenase family
A4V00_RS01005	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4V00_RS01010	COG2379	hydroxypyruvate reductase
A4V00_RS01015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4V00_RS01020	COG2084	Dehydrogenase
A4V00_RS01075	COG1268	BioY protein
A4V00_RS01080	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A4V00_RS01080	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A4V00_RS01205	COG4753	response regulator
A4V00_RS01205	COG2207	Transcriptional regulator
A4V00_RS01210	COG2972	Histidine kinase
A4V00_RS01220	COG0395	ABC-type sugar transport system, permease component
A4V00_RS01225	COG4209	transmembrane transport
A4V00_RS01230	COG1653	transport
A4V00_RS01235	COG4974	Belongs to the 'phage' integrase family
A4V00_RS01285	COG1136	(ABC) transporter
A4V00_RS01300	COG5002	protein histidine kinase activity
A4V00_RS01305	COG0745	RESPONSE REGULATOR receiver
A4V00_RS01320	COG1733	regulation of RNA biosynthetic process
A4V00_RS01340	COG4372	Transposase
A4V00_RS01455	COG1136	(ABC) transporter
A4V00_RS01455	COG0577	efflux transmembrane transporter activity
A4V00_RS01500	COG0395	ABC-type sugar transport system, permease component
A4V00_RS01505	COG2972	Histidine kinase
A4V00_RS01510	COG2207	Transcriptional regulator
A4V00_RS01510	COG4753	response regulator
A4V00_RS01515	COG1979	alcohol dehydrogenase
A4V00_RS01520	COG0583	DNA-binding transcription factor activity
A4V00_RS01550	COG1674	ftsk spoiiie
A4V00_RS01555	COG1968	undecaprenyl-diphosphatase activity
A4V00_RS01560	COG0740	serine-type endopeptidase activity
A4V00_RS01600	COG3854	ATPases associated with a variety of cellular activities
A4V00_RS01615	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A4V00_RS01625	COG1131	(ABC) transporter
A4V00_RS01630	COG1725	Transcriptional regulator
A4V00_RS01635	COG3119	arylsulfatase activity
A4V00_RS01645	COG2348	transferase activity, transferring amino-acyl groups
A4V00_RS01655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A4V00_RS01665	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A4V00_RS01670	COG1032	radical SAM domain protein
A4V00_RS01690	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A4V00_RS01700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4V00_RS01710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4V00_RS01720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4V00_RS01745	COG1088	dTDP-glucose 4,6-dehydratase activity
A4V00_RS01760	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A4V00_RS01770	COG1086	Polysaccharide biosynthesis protein
A4V00_RS01780	COG2046	Belongs to the sulfate adenylyltransferase family
A4V00_RS01780	COG0529	Catalyzes the synthesis of activated sulfate
A4V00_RS01870	COG3293	Transposase
A4V00_RS01880	COG5002	protein histidine kinase activity
A4V00_RS01885	COG3976	FMN-binding domain protein
A4V00_RS01885	COG0431	NADPH-dependent FMN reductase
A4V00_RS01885	COG1053	succinate dehydrogenase
A4V00_RS01930	COG4974	Belongs to the 'phage' integrase family
A4V00_RS01945	COG4974	Belongs to the 'phage' integrase family
A4V00_RS01985	COG1475	DNA binding
A4V00_RS02030	COG1132	(ABC) transporter
A4V00_RS02085	COG1373	ATPase (AAA superfamily
A4V00_RS02200	COG3293	Transposase
A4V00_RS02270	COG1131	(ABC) transporter
A4V00_RS02305	COG1484	DNA-dependent DNA replication
A4V00_RS02345	COG0519	Catalyzes the synthesis of GMP from XMP
A4V00_RS02350	COG0534	Mate efflux family protein
A4V00_RS02365	COG3842	ATPase activity
A4V00_RS02370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4V00_RS02385	COG0628	permease
A4V00_RS02395	COG1592	Rubrerythrin
A4V00_RS02410	COG0148	phosphopyruvate hydratase activity
A4V00_RS02425	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4V00_RS02425	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A4V00_RS02440	COG2226	methyltransferase
A4V00_RS02445	COG0750	zinc metalloprotease
A4V00_RS02455	COG1162	GTPase activity
A4V00_RS02460	COG0515	serine threonine protein kinase
A4V00_RS02460	COG2815	serine threonine protein kinase
A4V00_RS02465	COG0631	protein serine/threonine phosphatase activity
A4V00_RS02470	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A4V00_RS02475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4V00_RS02475	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A4V00_RS02480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A4V00_RS02485	COG0242	peptide deformylase activity
A4V00_RS02490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4V00_RS02495	COG1758	RNA polymerase activity
A4V00_RS02500	COG0194	GDP metabolic process
A4V00_RS02505	COG2052	Domain of unknown function (DUF370)
A4V00_RS02510	COG1561	YicC-like family, N-terminal region
A4V00_RS02520	COG0564	pseudouridine synthase activity
A4V00_RS02525	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A4V00_RS02545	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A4V00_RS02570	COG2226	methyltransferase
A4V00_RS02575	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4V00_RS02590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V00_RS02600	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4V00_RS02610	COG2226	methyltransferase
A4V00_RS02620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A4V00_RS02635	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A4V00_RS02640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4V00_RS02655	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V00_RS02665	COG0823	Involved in the tonB-independent uptake of proteins
A4V00_RS02680	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A4V00_RS02685	COG2309	aminopeptidase activity
A4V00_RS02690	COG1063	alcohol dehydrogenase
A4V00_RS02705	COG0606	chelatase, subunit chli
A4V00_RS02710	COG1489	DNA binding
A4V00_RS02725	COG0527	aspartate kinase activity
A4V00_RS02795	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4V00_RS02805	COG3620	sequence-specific DNA binding
A4V00_RS02900	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4V00_RS02910	COG3041	Addiction module toxin RelE StbE family
A4V00_RS02950	COG4509	Sortase family
A4V00_RS02970	COG3833	ABC-type maltose transport systems, permease component
A4V00_RS03060	COG1132	(ABC) transporter
A4V00_RS03075	COG1175	transmembrane transport
A4V00_RS03105	COG0681	Belongs to the peptidase S26 family
A4V00_RS03125	COG2161	toxin-antitoxin pair type II binding
A4V00_RS03295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4V00_RS03330	COG1192	Involved in chromosome partitioning
A4V00_RS03335	COG1475	DNA binding
A4V00_RS03370	COG5002	protein histidine kinase activity
A4V00_RS03390	COG1136	(ABC) transporter
A4V00_RS03395	COG5002	protein histidine kinase activity
A4V00_RS03400	COG0745	RESPONSE REGULATOR receiver
A4V00_RS03430	COG0629	single-stranded DNA binding
A4V00_RS03495	COG1396	sequence-specific DNA binding
A4V00_RS03550	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4V00_RS03580	COG4509	Sortase family
A4V00_RS03600	COG1979	alcohol dehydrogenase
A4V00_RS03610	COG0191	fructose-bisphosphate aldolase activity
A4V00_RS03615	COG1621	beta-fructofuranosidase activity
A4V00_RS03625	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4V00_RS03630	COG1882	Formate acetyltransferase
A4V00_RS03635	COG3534	alpha-L-arabinofuranosidase
A4V00_RS03645	COG0395	ABC-type sugar transport system, permease component
A4V00_RS03650	COG4209	transmembrane transport
A4V00_RS03655	COG1609	Transcriptional regulator
A4V00_RS03660	COG1621	beta-fructofuranosidase activity
A4V00_RS03725	COG1373	ATPase (AAA superfamily
A4V00_RS03745	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A4V00_RS03765	COG0640	Transcriptional regulator
A4V00_RS03785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4V00_RS03790	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A4V00_RS03795	COG0745	RESPONSE REGULATOR receiver
A4V00_RS03800	COG5002	protein histidine kinase activity
A4V00_RS03815	COG1136	(ABC) transporter
A4V00_RS03820	COG0745	RESPONSE REGULATOR receiver
A4V00_RS03870	COG1136	(ABC) transporter
A4V00_RS03885	COG5002	protein histidine kinase activity
A4V00_RS03885	COG3850	Histidine kinase
A4V00_RS03890	COG0745	RESPONSE REGULATOR receiver
A4V00_RS03905	COG2226	methyltransferase
A4V00_RS03920	COG1175	transmembrane transport
A4V00_RS03985	COG4209	transmembrane transport
A4V00_RS03990	COG0395	ABC-type sugar transport system, permease component
A4V00_RS04005	COG2703	oxygen carrier activity
A4V00_RS04010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4V00_RS04030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4V00_RS04040	COG0613	PHP domain protein
A4V00_RS04045	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4V00_RS04050	COG0328	RNA-DNA hybrid ribonuclease activity
A4V00_RS04075	COG0577	efflux transmembrane transporter activity
A4V00_RS04095	COG1131	(ABC) transporter
A4V00_RS04100	COG1757	Na H antiporter
A4V00_RS04105	COG1132	(ABC) transporter
A4V00_RS04110	COG1132	(ABC) transporter
A4V00_RS04115	COG0840	transmembrane signaling receptor activity
A4V00_RS04145	COG0538	isocitrate dehydrogenase activity
A4V00_RS04160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4V00_RS04175	COG1733	regulation of RNA biosynthetic process
A4V00_RS04180	COG0542	response to heat
A4V00_RS04185	COG3869	Catalyzes the specific phosphorylation of arginine residues in
A4V00_RS04190	COG3880	PFAM UvrB UvrC protein
A4V00_RS04200	COG4463	regulation of RNA biosynthetic process
A4V00_RS04215	COG3842	ATPase activity
A4V00_RS04225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4V00_RS04230	COG1882	Formate acetyltransferase
A4V00_RS04240	COG0673	inositol 2-dehydrogenase activity
A4V00_RS04255	COG0673	inositol 2-dehydrogenase activity
A4V00_RS04260	COG0395	ABC-type sugar transport system, permease component
A4V00_RS04265	COG1175	transmembrane transport
A4V00_RS04275	COG2197	response regulator
A4V00_RS04280	COG2972	Histidine kinase
A4V00_RS04285	COG0673	inositol 2-dehydrogenase activity
A4V00_RS04295	COG0038	chloride channel
A4V00_RS04315	COG1396	sequence-specific DNA binding
A4V00_RS04320	COG1307	EDD domain protein, DegV family
A4V00_RS04330	COG1737	Transcriptional regulator
A4V00_RS04360	COG0235	Class ii aldolase
A4V00_RS04370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4V00_RS04380	COG0700	Nucleoside recognition
A4V00_RS04390	COG1063	alcohol dehydrogenase
A4V00_RS04400	COG1454	alcohol dehydrogenase
A4V00_RS04400	COG1012	belongs to the aldehyde dehydrogenase family
A4V00_RS04410	COG0534	Mate efflux family protein
A4V00_RS04420	COG1959	2 iron, 2 sulfur cluster binding
A4V00_RS04425	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A4V00_RS04435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4V00_RS04445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A4V00_RS04450	COG4684	Psort location CytoplasmicMembrane, score
A4V00_RS04455	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A4V00_RS04460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4V00_RS04465	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A4V00_RS04470	COG1570	exodeoxyribonuclease VII activity
A4V00_RS04475	COG1722	exodeoxyribonuclease VII activity
A4V00_RS04480	COG0142	geranyltranstransferase activity
A4V00_RS04485	COG0564	pseudouridine synthase activity
A4V00_RS04495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4V00_RS04515	COG0440	acetolactate synthase activity
A4V00_RS04540	COG0129	dihydroxy-acid dehydratase activity
A4V00_RS04555	COG2205	protein histidine kinase activity
A4V00_RS04585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4V00_RS04590	COG0287	Prephenate dehydrogenase
A4V00_RS04595	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A4V00_RS04600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4V00_RS04605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4V00_RS04620	COG0673	inositol 2-dehydrogenase activity
A4V00_RS04630	COG4166	transmembrane transport
A4V00_RS04645	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4V00_RS04655	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A4V00_RS04660	COG1596	polysaccharide export
A4V00_RS04660	COG1555	photosystem II stabilization
A4V00_RS04665	COG1187	pseudouridine synthase activity
A4V00_RS04670	COG1686	Belongs to the peptidase S11 family
A4V00_RS04675	COG3874	Sporulation protein YtfJ
A4V00_RS04685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A4V00_RS04690	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A4V00_RS04695	COG1994	Peptidase M50
A4V00_RS04700	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A4V00_RS04705	COG0668	transmembrane transport
A4V00_RS04745	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4V00_RS04755	COG0126	phosphoglycerate kinase activity
A4V00_RS04760	COG0149	triose-phosphate isomerase activity
A4V00_RS04770	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A4V00_RS04785	COG0584	glycerophosphoryl diester phosphodiesterase
A4V00_RS04795	COG0789	Transcriptional regulator
A4V00_RS04830	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A4V00_RS04835	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A4V00_RS04840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4V00_RS04845	COG0494	nUDIX hydrolase
A4V00_RS04850	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A4V00_RS04855	COG1160	GTP binding
A4V00_RS04870	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A4V00_RS04885	COG0166	Belongs to the GPI family
A4V00_RS04890	COG1686	Belongs to the peptidase S11 family
A4V00_RS04985	COG0084	hydrolase, TatD family'
A4V00_RS05025	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A4V00_RS05045	COG0318	PFAM AMP-dependent synthetase and ligase
A4V00_RS05065	COG0671	phosphoesterase, PA-phosphatase related
A4V00_RS05085	COG5002	protein histidine kinase activity
A4V00_RS05085	COG2205	protein histidine kinase activity
A4V00_RS05085	COG0784	Response regulator, receiver
A4V00_RS05090	COG0488	(ABC) transporter
A4V00_RS05095	COG1598	PFAM Uncharacterised protein family UPF0150
A4V00_RS05120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4V00_RS05130	COG0363	glucosamine-6-phosphate deaminase activity
A4V00_RS05155	COG1131	(ABC) transporter
A4V00_RS05185	COG0590	tRNA wobble adenosine to inosine editing
A4V00_RS05190	COG5002	protein histidine kinase activity
A4V00_RS05220	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A4V00_RS05225	COG0006	proline dipeptidase activity
A4V00_RS05245	COG3279	Response regulator of the LytR AlgR family
A4V00_RS05310	COG2205	protein histidine kinase activity
A4V00_RS05315	COG0745	RESPONSE REGULATOR receiver
A4V00_RS05440	COG1484	DNA-dependent DNA replication
A4V00_RS05460	COG1475	DNA binding
A4V00_RS05470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4V00_RS05490	COG5002	protein histidine kinase activity
A4V00_RS05495	COG0745	RESPONSE REGULATOR receiver
A4V00_RS05545	COG1475	DNA binding
A4V00_RS05675	COG1733	regulation of RNA biosynthetic process
A4V00_RS05690	COG0588	phosphoglycerate mutase activity
A4V00_RS05700	COG0789	Transcriptional regulator
A4V00_RS05710	COG1733	regulation of RNA biosynthetic process
A4V00_RS05740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4V00_RS05755	COG1396	sequence-specific DNA binding
A4V00_RS05765	COG3279	Response regulator of the LytR AlgR family
A4V00_RS05795	COG2814	Major facilitator Superfamily
A4V00_RS05925	COG0577	efflux transmembrane transporter activity
A4V00_RS05925	COG1136	(ABC) transporter
A4V00_RS05945	COG1595	DNA-templated transcription, initiation
A4V00_RS06040	COG5290	Psort location Cytoplasmic, score
A4V00_RS06045	COG5290	Psort location Cytoplasmic, score
A4V00_RS06050	COG2801	Transposase and inactivated derivatives
A4V00_RS06070	COG0107	imidazoleglycerol-phosphate synthase activity
A4V00_RS06095	COG3959	Transketolase, thiamine diphosphate binding domain
A4V00_RS06100	COG3958	Transketolase
A4V00_RS06105	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A4V00_RS06115	COG2873	o-acetylhomoserine
A4V00_RS06125	COG0525	valine-tRNA ligase activity
A4V00_RS06150	COG0444	Belongs to the ABC transporter superfamily
A4V00_RS06150	COG0444	Belongs to the ABC transporter superfamily
A4V00_RS06155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4V00_RS06160	COG0601	transmembrane transport
A4V00_RS06165	COG4166	transmembrane transport
A4V00_RS06170	COG5002	protein histidine kinase activity
A4V00_RS06170	COG2205	protein histidine kinase activity
A4V00_RS06170	COG0784	Response regulator, receiver
A4V00_RS06190	COG0564	pseudouridine synthase activity
A4V00_RS06200	COG0438	transferase activity, transferring glycosyl groups
A4V00_RS06205	COG0714	Associated with various cellular activities
A4V00_RS06225	COG0456	acetyltransferase
A4V00_RS06265	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A4V00_RS06300	COG0723	plastoquinol--plastocyanin reductase activity
A4V00_RS06300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4V00_RS06305	COG1253	flavin adenine dinucleotide binding
A4V00_RS06320	COG0534	Mate efflux family protein
A4V00_RS06340	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
A4V00_RS06350	COG3266	domain, Protein
A4V00_RS06350	COG2911	Protein conserved in bacteria
A4V00_RS06350	COG1361	Conserved repeat domain
A4V00_RS06365	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A4V00_RS06380	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A4V00_RS06385	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A4V00_RS06390	COG0009	L-threonylcarbamoyladenylate synthase
A4V00_RS06395	COG0741	lytic transglycosylase activity
A4V00_RS06410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A4V00_RS06415	COG1323	Belongs to the UPF0348 family
A4V00_RS06420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A4V00_RS06420	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A4V00_RS06435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4V00_RS06440	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A4V00_RS06445	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A4V00_RS06455	COG2267	carboxylic ester hydrolase activity
A4V00_RS06470	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A4V00_RS06480	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A4V00_RS06525	COG0217	transcriptional regulatory protein
A4V00_RS06540	COG1971	Probably functions as a manganese efflux pump
A4V00_RS06545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4V00_RS06565	COG0058	SHG alpha-glucan phosphorylase activity
A4V00_RS06580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A4V00_RS06590	COG0653	protein targeting
A4V00_RS06625	COG1408	metallophosphoesterase
A4V00_RS06630	COG2183	response to ionizing radiation
A4V00_RS06665	COG0426	domain, Protein
A4V00_RS06685	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V00_RS06705	COG2706	6-phosphogluconolactonase activity
A4V00_RS06715	COG0789	Transcriptional regulator
A4V00_RS06720	COG1028	Short-chain dehydrogenase reductase Sdr
A4V00_RS06725	COG1904	glucuronate isomerase
A4V00_RS06730	COG1312	Catalyzes the dehydration of D-mannonate
A4V00_RS06735	COG3250	beta-galactosidase activity
A4V00_RS06740	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4V00_RS06750	COG0360	Binds together with S18 to 16S ribosomal RNA
A4V00_RS06760	COG3408	Glycogen debranching enzyme
A4V00_RS06780	COG1191	sigma factor activity
A4V00_RS06800	COG2205	protein histidine kinase activity
A4V00_RS06810	COG0726	polysaccharide deacetylase
A4V00_RS06820	COG2081	HI0933 family
A4V00_RS06825	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A4V00_RS06830	COG0657	acetylesterase activity
A4V00_RS06835	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A4V00_RS06835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A4V00_RS06840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4V00_RS06845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4V00_RS06850	COG0572	uridine kinase
A4V00_RS06860	COG1132	(ABC) transporter
A4V00_RS06865	COG1132	(ABC) transporter
A4V00_RS06870	COG1216	Glycosyl transferase, family 2
A4V00_RS06870	COG1442	glycosyl transferase family 8
A4V00_RS06875	COG2244	polysaccharide biosynthetic process
A4V00_RS06880	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4V00_RS06880	COG0463	Glycosyl transferase, family 2
A4V00_RS06885	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4V00_RS06895	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A4V00_RS06915	COG4770	biotin carboxylase activity
A4V00_RS06940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4V00_RS06970	COG0673	inositol 2-dehydrogenase activity
A4V00_RS06985	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A4V00_RS07015	COG0530	calcium, potassium:sodium antiporter activity
A4V00_RS07035	COG0800	Aldolase
A4V00_RS07040	COG0129	dihydroxy-acid dehydratase activity
A4V00_RS07050	COG1956	GAF domain-containing protein
A4V00_RS07055	COG0673	inositol 2-dehydrogenase activity
A4V00_RS07065	COG1028	Short-chain dehydrogenase reductase Sdr
A4V00_RS07070	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A4V00_RS07120	COG1132	(ABC) transporter
A4V00_RS07125	COG1132	(ABC) transporter
A4V00_RS07130	COG1272	protein, Hemolysin III
A4V00_RS07135	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A4V00_RS07155	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4V00_RS07160	COG0768	penicillin binding
A4V00_RS07165	COG1482	cell wall glycoprotein biosynthetic process
A4V00_RS07170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V00_RS07175	COG0295	cytidine deaminase activity
A4V00_RS07180	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A4V00_RS07185	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4V00_RS07190	COG0708	Exodeoxyribonuclease III
A4V00_RS07200	COG1132	(ABC) transporter
A4V00_RS07210	COG0557	exoribonuclease II activity
A4V00_RS07230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V00_RS07235	COG0488	(ABC) transporter
A4V00_RS07240	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4V00_RS07245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4V00_RS07265	COG3579	cysteine-type endopeptidase activity
A4V00_RS07270	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4V00_RS07285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4V00_RS07290	COG3850	Histidine kinase
A4V00_RS07290	COG5002	protein histidine kinase activity
A4V00_RS07295	COG0745	RESPONSE REGULATOR receiver
A4V00_RS07320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A4V00_RS07325	COG0561	phosphatase activity
A4V00_RS07335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4V00_RS07340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4V00_RS07345	COG0049	tRNA binding
A4V00_RS07350	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A4V00_RS07355	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A4V00_RS07360	COG0085	RNA polymerase activity
A4V00_RS07365	COG0456	acetyltransferase
A4V00_RS07380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4V00_RS07385	COG0358	DNA primase activity
A4V00_RS07390	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A4V00_RS07395	COG1739	Uncharacterized protein family UPF0029
A4V00_RS07405	COG0254	rRNA binding
A4V00_RS07430	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A4V00_RS07435	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A4V00_RS07440	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A4V00_RS07445	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A4V00_RS07450	COG1395	domain, Protein
A4V00_RS07460	COG0540	Belongs to the ATCase OTCase family
A4V00_RS07475	COG1074	ATP-dependent DNA helicase activity
A4V00_RS07495	COG1063	alcohol dehydrogenase
A4V00_RS07510	COG2270	Major facilitator Superfamily
A4V00_RS07515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4V00_RS07520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4V00_RS07535	COG0372	Belongs to the citrate synthase family
A4V00_RS07555	COG0739	heme binding
A4V00_RS07575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4V00_RS07580	COG2720	vancomycin resistance protein
A4V00_RS07590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4V00_RS07595	COG1104	cysteine desulfurase activity
A4V00_RS07605	COG0301	tRNA thio-modification
A4V00_RS07615	COG1546	Belongs to the CinA family
A4V00_RS07615	COG1058	Belongs to the CinA family
A4V00_RS07620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4V00_RS07625	COG1394	ATPase activity, coupled to movement of substances
A4V00_RS07630	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
A4V00_RS07635	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
A4V00_RS07640	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
A4V00_RS07655	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4V00_RS07660	COG1269	ATP hydrolysis coupled proton transport
A4V00_RS07675	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A4V00_RS07680	COG0193	aminoacyl-tRNA hydrolase activity
A4V00_RS07685	COG0574	Belongs to the PEP-utilizing enzyme family
A4V00_RS07685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4V00_RS07695	COG2337	Toxic component of a toxin-antitoxin (TA) module
A4V00_RS07700	COG1191	sigma factor activity
A4V00_RS07730	COG1136	(ABC) transporter
A4V00_RS07735	COG0577	efflux transmembrane transporter activity
A4V00_RS07750	COG1917	Cupin 2, conserved barrel domain protein
A4V00_RS07750	COG2207	Transcriptional regulator
A4V00_RS07755	COG0745	RESPONSE REGULATOR receiver
A4V00_RS07760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4V00_RS07810	COG1129	ABC transporter
A4V00_RS07815	COG1132	(ABC) transporter
A4V00_RS07825	COG3843	relaxase mobilization nuclease domain protein
A4V00_RS07865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4V00_RS07870	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4V00_RS07910	COG0789	Transcriptional regulator
A4V00_RS07915	COG3534	alpha-L-arabinofuranosidase
A4V00_RS07920	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V00_RS07935	COG0367	asparagine synthase
A4V00_RS07970	COG3976	FMN-binding domain protein
A4V00_RS07970	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A4V00_RS07980	COG1132	(ABC) transporter
A4V00_RS07995	COG4988	ABC transporter
A4V00_RS08000	COG1132	(ABC) transporter
A4V00_RS08005	COG2832	Protein of unknown function (DUF454)
A4V00_RS08015	COG1876	peptidase activity
A4V00_RS08065	COG2801	Transposase and inactivated derivatives
A4V00_RS08070	COG1132	(ABC) transporter
A4V00_RS08180	COG3022	response to hydroperoxide
A4V00_RS08185	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A4V00_RS08190	COG3708	Transcriptional regulator
A4V00_RS08190	COG2207	Transcriptional regulator
A4V00_RS08195	COG0840	transmembrane signaling receptor activity
A4V00_RS08200	COG0667	Aldo Keto reductase
A4V00_RS08215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A4V00_RS08220	COG1609	Transcriptional regulator
A4V00_RS08225	COG1395	domain, Protein
A4V00_RS08265	COG2361	Protein of unknown function DUF86
A4V00_RS08285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4V00_RS08295	COG0622	Phosphoesterase
A4V00_RS08305	COG1621	beta-fructofuranosidase activity
A4V00_RS08305	COG3583	domain protein
A4V00_RS08305	COG5492	domain, Protein
A4V00_RS08325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4V00_RS08330	COG0481	GTPase activity
A4V00_RS08340	COG0423	glycine-tRNA ligase activity
A4V00_RS08410	COG5002	protein histidine kinase activity
A4V00_RS08415	COG0745	RESPONSE REGULATOR receiver
A4V00_RS08420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A4V00_RS08425	COG2848	UPF0210 protein
A4V00_RS08435	COG3830	Belongs to the UPF0237 family
A4V00_RS08450	COG2272	Belongs to the type-B carboxylesterase lipase family
A4V00_RS08520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A4V00_RS08540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4V00_RS08555	COG0300	oxidoreductase activity
A4V00_RS08575	COG0012	GTP binding
A4V00_RS08585	COG2267	carboxylic ester hydrolase activity
A4V00_RS08590	COG2155	Conserved Protein
A4V00_RS08595	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4V00_RS08595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4V00_RS08600	COG0539	negative regulation of cytoplasmic translation
A4V00_RS08600	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A4V00_RS08605	COG0318	PFAM AMP-dependent synthetase and ligase
A4V00_RS08605	COG0204	Acyl-transferase
A4V00_RS08610	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A4V00_RS08630	COG2081	HI0933 family
A4V00_RS08645	COG0484	heat shock protein binding
A4V00_RS08660	COG0494	nUDIX hydrolase
A4V00_RS08675	COG0492	ferredoxin-NADP+ reductase activity
A4V00_RS08680	COG3118	belongs to the thioredoxin family
A4V00_RS08705	COG1070	Carbohydrate kinase
A4V00_RS08710	COG1307	EDD domain protein, DegV family
A4V00_RS08740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4V00_RS08745	COG0300	oxidoreductase activity
A4V00_RS08750	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A4V00_RS08755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A4V00_RS08780	COG2003	Belongs to the UPF0758 family
A4V00_RS08785	COG0556	nucleotide-excision repair
A4V00_RS08795	COG0456	acetyltransferase
A4V00_RS08795	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A4V00_RS08835	COG1185	polyribonucleotide nucleotidyltransferase activity
A4V00_RS08850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4V00_RS08855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V00_RS08865	COG1295	ribonuclease BN
A4V00_RS08875	COG0482	sulfurtransferase activity
A4V00_RS08910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4V00_RS08920	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4V00_RS08925	COG1028	Short-chain dehydrogenase reductase Sdr
A4V00_RS08930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4V00_RS08945	COG0439	Biotin carboxylase
A4V00_RS08950	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A4V00_RS08955	COG0825	malonyl-CoA metabolic process
A4V00_RS08965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4V00_RS08970	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4V00_RS08975	COG0537	adenosine 5'-monophosphoramidase activity
A4V00_RS09005	COG3534	alpha-L-arabinofuranosidase
A4V00_RS09020	COG0582	viral genome integration into host DNA
A4V00_RS09075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4V00_RS09080	COG0187	DNA topoisomerase II activity
A4V00_RS09095	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A4V00_RS09100	COG2501	S4 domain
A4V00_RS09105	COG0592	DNA-directed DNA polymerase activity
A4V00_RS09120	COG1695	Transcriptional regulator
A4V00_RS09135	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A4V00_RS09140	COG0706	membrane insertase activity
A4V00_RS09145	COG1847	R3H domain protein
A4V00_RS09150	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A4V00_RS09155	COG0445	tRNA wobble uridine modification
A4V00_RS09160	COG0357	Ribosomal RNA small subunit methyltransferase G
A4V00_RS09170	COG1475	DNA binding
A4V00_RS09175	COG1192	Involved in chromosome partitioning
A4V00_RS09180	COG1475	DNA binding
A4V00_RS09185	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A4V00_RS09210	COG0516	GMP reductase activity
A4V00_RS09210	COG0517	IMP dehydrogenase activity
A4V00_RS09225	COG2207	Transcriptional regulator
A4V00_RS09225	COG3708	Transcriptional regulator
A4V00_RS09260	COG0456	acetyltransferase
A4V00_RS09265	COG2226	methyltransferase
A4V00_RS09290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A4V00_RS09295	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A4V00_RS09300	COG1388	LysM domain
A4V00_RS09300	COG3584	3D domain protein
A4V00_RS09315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4V00_RS09330	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A4V00_RS09340	COG1215	transferase activity, transferring glycosyl groups
A4V00_RS09365	COG1595	DNA-templated transcription, initiation
A4V00_RS09375	COG0667	Aldo Keto reductase
A4V00_RS09380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4V00_RS09385	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4V00_RS09395	COG1162	GTPase activity
A4V00_RS09400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4V00_RS09430	COG0768	penicillin binding
A4V00_RS09440	COG1115	amino acid carrier protein
A4V00_RS09450	COG0726	polysaccharide deacetylase
A4V00_RS09450	COG1649	PFAM Uncharacterised BCR, COG1649
A4V00_RS09455	COG0561	phosphatase activity
A4V00_RS09465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4V00_RS09465	COG0357	Ribosomal RNA small subunit methyltransferase G
A4V00_RS09490	COG0534	Mate efflux family protein
A4V00_RS09500	COG0667	Aldo Keto reductase
A4V00_RS09505	COG0667	Aldo Keto reductase
A4V00_RS09550	COG0640	Transcriptional regulator
A4V00_RS09555	COG0640	Transcriptional regulator
A4V00_RS09565	COG1733	regulation of RNA biosynthetic process
A4V00_RS09615	COG1979	alcohol dehydrogenase
A4V00_RS09650	COG0667	Aldo Keto reductase
A4V00_RS09725	COG1475	DNA binding
A4V00_RS09790	COG1733	regulation of RNA biosynthetic process
A4V00_RS09890	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4V00_RS09900	COG3655	Transcriptional regulator
A4V00_RS09920	COG0281	malic enzyme
A4V00_RS09935	COG1132	(ABC) transporter
A4V00_RS09940	COG1132	(ABC) transporter
A4V00_RS09945	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4V00_RS09955	COG3800	Transcriptional regulator
A4V00_RS09955	COG1396	sequence-specific DNA binding
A4V00_RS09960	COG1418	mRNA catabolic process
A4V00_RS09965	COG1692	metallophosphoesterase
A4V00_RS09970	COG1461	Dihydroxyacetone kinase
A4V00_RS09975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A4V00_RS09985	COG1191	sigma factor activity
A4V00_RS09990	COG1760	l-serine dehydratase
A4V00_RS10005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4V00_RS10020	COG2002	toxin-antitoxin pair type II binding
A4V00_RS10030	COG0195	Participates in both transcription termination and antitermination
A4V00_RS10035	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A4V00_RS10045	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A4V00_RS10050	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A4V00_RS10055	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A4V00_RS10060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A4V00_RS10065	COG0196	riboflavin kinase activity
A4V00_RS10075	COG0824	Thioesterase
A4V00_RS10095	COG0745	RESPONSE REGULATOR receiver
A4V00_RS10100	COG5002	protein histidine kinase activity
A4V00_RS10105	COG3872	metal-dependent enzyme
A4V00_RS10110	COG2890	protein-(glutamine-N5) methyltransferase activity
A4V00_RS10115	COG2137	regulation of response to DNA damage stimulus
A4V00_RS10120	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A4V00_RS10140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4V00_RS10155	COG0051	transcription antitermination factor activity, RNA binding
A4V00_RS10160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A4V00_RS10165	COG0088	Forms part of the polypeptide exit tunnel
A4V00_RS10170	COG0089	rRNA binding
A4V00_RS10175	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A4V00_RS10180	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A4V00_RS10190	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A4V00_RS10195	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A4V00_RS10205	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A4V00_RS10210	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A4V00_RS10215	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A4V00_RS10220	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A4V00_RS10225	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A4V00_RS10235	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A4V00_RS10245	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A4V00_RS10255	COG0200	Binds to the 23S rRNA
A4V00_RS10265	COG0563	adenylate kinase activity
A4V00_RS10280	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A4V00_RS10285	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A4V00_RS10290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A4V00_RS10295	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A4V00_RS10300	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A4V00_RS10305	COG0202	RNA polymerase activity
A4V00_RS10315	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A4V00_RS10320	COG1040	competence protein
A4V00_RS10330	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A4V00_RS10335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A4V00_RS10345	COG1757	Na H antiporter
A4V00_RS10370	COG4656	Part of a membrane complex involved in electron transport
A4V00_RS10375	COG4658	electron transport chain
A4V00_RS10380	COG4659	FMN binding
A4V00_RS10385	COG4660	Part of a membrane complex involved in electron transport
A4V00_RS10390	COG4657	Part of a membrane complex involved in electron transport
A4V00_RS10475	COG3853	Toxic anion resistance protein (TelA)
A4V00_RS10490	COG0561	phosphatase activity
A4V00_RS10495	COG0641	radical SAM
A4V00_RS10505	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A4V00_RS10515	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4V00_RS10520	COG2205	protein histidine kinase activity
A4V00_RS10520	COG0784	Response regulator, receiver
A4V00_RS10520	COG5002	protein histidine kinase activity
A4V00_RS10530	COG3437	response regulator, receiver
A4V00_RS10540	COG2272	Belongs to the type-B carboxylesterase lipase family
A4V00_RS10560	COG2801	Transposase and inactivated derivatives
A4V00_RS10610	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A4V00_RS10615	COG5566	PFAM Mor transcription activator
A4V00_RS10625	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4V00_RS10660	COG2217	Heavy metal translocating P-type atpase
A4V00_RS10670	COG2217	Heavy metal translocating P-type atpase
A4V00_RS10710	COG1475	DNA binding
A4V00_RS10730	COG0456	acetyltransferase
A4V00_RS10735	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A4V00_RS10760	COG0596	Alpha beta hydrolase
A4V00_RS10775	COG0072	phenylalanine-tRNA ligase activity
A4V00_RS10780	COG4472	Bacterial protein of unknown function (DUF965)
A4V00_RS10795	COG2252	PERMEase
A4V00_RS10805	COG0534	Mate efflux family protein
A4V00_RS10815	COG1278	Cold shock
A4V00_RS10825	COG0714	Associated with various cellular activities
A4V00_RS10840	COG0673	inositol 2-dehydrogenase activity
A4V00_RS10855	COG0673	inositol 2-dehydrogenase activity
A4V00_RS10885	COG2244	polysaccharide biosynthetic process
A4V00_RS10890	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A4V00_RS10895	COG0419	ATPase involved in DNA repair
A4V00_RS10900	COG0420	3'-5' exonuclease activity
A4V00_RS10905	COG1686	Belongs to the peptidase S11 family
A4V00_RS10910	COG0822	iron-sulfur transferase activity
A4V00_RS10920	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A4V00_RS10925	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A4V00_RS10935	COG0359	binds to the 23S rRNA
A4V00_RS10940	COG0305	Participates in initiation and elongation during chromosome replication
A4V00_RS10955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4V00_RS10960	COG0187	DNA topoisomerase II activity
A4V00_RS10970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4V00_RS10985	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A4V00_RS10990	COG0632	four-way junction helicase activity
A4V00_RS11005	COG2255	four-way junction helicase activity
A4V00_RS11020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4V00_RS11030	COG0116	Belongs to the methyltransferase superfamily
A4V00_RS11030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A4V00_RS11040	COG1122	ATPase activity
A4V00_RS11065	COG1122	ATPase activity
A4V00_RS11070	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A4V00_RS11075	COG0101	tRNA pseudouridine synthase activity
A4V00_RS11090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4V00_RS11105	COG1454	alcohol dehydrogenase
A4V00_RS11105	COG1454	alcohol dehydrogenase
A4V00_RS11110	COG0235	Class ii aldolase
A4V00_RS11120	COG1070	Carbohydrate kinase
A4V00_RS11120	COG4806	L-rhamnose isomerase
A4V00_RS11140	COG0534	Mate efflux family protein
A4V00_RS11145	COG1217	gtp-binding protein TYPA
A4V00_RS11170	COG1362	aminopeptidase activity
A4V00_RS11180	COG0534	Mate efflux family protein
A4V00_RS11255	COG0270	DNA (cytosine-5-)-methyltransferase activity
A4V00_RS11260	COG0582	viral genome integration into host DNA
A4V00_RS11280	COG1774	PSP1 C-terminal conserved region
A4V00_RS11290	COG3870	Protein conserved in bacteria
A4V00_RS11305	COG1321	iron dependent repressor
A4V00_RS11315	COG2890	protein-(glutamine-N5) methyltransferase activity
A4V00_RS11320	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A4V00_RS11340	COG1132	(ABC) transporter
A4V00_RS11345	COG1132	(ABC) transporter
A4V00_RS11360	COG3250	beta-galactosidase activity
A4V00_RS11375	COG1605	Chorismate mutase
A4V00_RS11375	COG0077	Prephenate dehydratase
A4V00_RS11400	COG1120	ATPase activity
A4V00_RS11420	COG1132	(ABC) transporter
A4V00_RS11425	COG1132	(ABC) transporter
A4V00_RS11430	COG1309	transcriptional regulator
A4V00_RS11490	COG3279	Response regulator of the LytR AlgR family
A4V00_RS11570	COG3022	response to hydroperoxide
A4V00_RS11575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A4V00_RS11590	COG4372	Transposase
A4V00_RS11605	COG3436	PFAM IS66 Orf2 family protein
A4V00_RS11640	COG3843	relaxase mobilization nuclease domain protein
A4V00_RS11675	COG1191	sigma factor activity
A4V00_RS11755	COG4509	Sortase family
A4V00_RS11940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4V00_RS12025	COG1191	sigma factor activity
A4V00_RS12040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4V00_RS12050	COG2502	aspartate--ammonia ligase
A4V00_RS12055	COG0251	oxidation-reduction process
A4V00_RS12065	COG4377	Putative membrane peptidase family (DUF2324)
A4V00_RS12080	COG0252	asparaginase activity
A4V00_RS12130	COG1396	sequence-specific DNA binding
A4V00_RS12200	COG4166	transmembrane transport
A4V00_RS12210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4V00_RS12215	COG0444	Belongs to the ABC transporter superfamily
A4V00_RS12220	COG4608	Belongs to the ABC transporter superfamily
A4V00_RS12225	COG1082	Xylose isomerase domain protein TIM barrel
A4V00_RS12235	COG0066	3-isopropylmalate dehydratase activity
A4V00_RS12250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4V00_RS12255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4V00_RS12285	COG2378	regulation of single-species biofilm formation
A4V00_RS12295	COG0312	modulator of DNA gyrase
A4V00_RS12305	COG0488	(ABC) transporter
A4V00_RS12355	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A4V00_RS12375	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A4V00_RS12390	COG0052	Belongs to the universal ribosomal protein uS2 family
A4V00_RS12400	COG0569	domain protein
A4V00_RS12415	COG0456	acetyltransferase
A4V00_RS12420	COG1592	Rubrerythrin
A4V00_RS12420	COG1773	rubredoxin
A4V00_RS12425	COG1773	rubredoxin
A4V00_RS12435	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4V00_RS12470	COG1874	Beta-galactosidase
A4V00_RS12475	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4V00_RS12480	COG1045	serine acetyltransferase
A4V00_RS12485	COG0215	cysteine-tRNA ligase activity
A4V00_RS12500	COG1918	ferrous iron import across plasma membrane
A4V00_RS12500	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A4V00_RS12525	COG0534	Mate efflux family protein
A4V00_RS12530	COG1621	beta-fructofuranosidase activity
A4V00_RS12535	COG2382	esterase
A4V00_RS12535	COG3693	PFAM glycoside hydrolase, family 10
A4V00_RS12555	COG0395	ABC-type sugar transport system, permease component
A4V00_RS12560	COG0366	Alpha amylase catalytic
A4V00_RS12565	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A4V00_RS12580	COG1737	Transcriptional regulator
A4V00_RS12600	COG4209	transmembrane transport
A4V00_RS12605	COG0395	ABC-type sugar transport system, permease component
A4V00_RS12610	COG1653	transport
A4V00_RS12620	COG2017	converts alpha-aldose to the beta-anomer
A4V00_RS12665	COG4974	Belongs to the 'phage' integrase family
A4V00_RS12800	COG3843	relaxase mobilization nuclease domain protein
A4V00_RS12810	COG4974	Belongs to the 'phage' integrase family
A4V00_RS12840	COG4209	transmembrane transport
A4V00_RS12845	COG0395	ABC-type sugar transport system, permease component
A4V00_RS12850	COG3693	PFAM glycoside hydrolase, family 10
A4V00_RS12850	COG2382	esterase
A4V00_RS12860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4V00_RS12865	COG2851	Citrate transporter
A4V00_RS12875	COG2272	Belongs to the type-B carboxylesterase lipase family
A4V00_RS12910	COG4974	Belongs to the 'phage' integrase family
A4V00_RS12945	COG1396	sequence-specific DNA binding
A4V00_RS12945	COG1917	Cupin 2, conserved barrel domain protein
A4V00_RS12950	COG0826	peptidase U32
A4V00_RS12955	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A4V00_RS12965	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A4V00_RS12985	COG0778	Nitroreductase
A4V00_RS13000	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A4V00_RS13000	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A4V00_RS13005	COG1283	sodium-dependent phosphate transmembrane transporter activity
A4V00_RS13010	COG1476	TRANSCRIPTIONal
A4V00_RS13020	COG1381	Involved in DNA repair and RecF pathway recombination
A4V00_RS13030	COG1193	negative regulation of DNA recombination
A4V00_RS13035	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A4V00_RS13040	COG1522	sequence-specific DNA binding
A4V00_RS13045	COG0436	Aminotransferase
A4V00_RS13050	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A4V00_RS13065	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A4V00_RS13080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A4V00_RS13085	COG4209	transmembrane transport
A4V00_RS13090	COG0395	ABC-type sugar transport system, permease component
A4V00_RS13095	COG1653	transport
A4V00_RS13130	COG2337	Toxic component of a toxin-antitoxin (TA) module
A4V00_RS13220	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4V00_RS13365	COG4372	Transposase
A4V00_RS13380	COG3436	PFAM IS66 Orf2 family protein
A4V00_RS13510	COG5484	DNA packaging
A4V00_RS13635	COG3409	Peptidoglycan-binding domain 1 protein
A4V00_RS13635	COG5632	N-Acetylmuramoyl-L-alanine amidase
A4V00_RS13635	COG1388	LysM domain
A4V00_RS13645	COG1783	phage Terminase large subunit
A4V00_RS13675	COG3546	catalase activity
A4V00_RS13685	COG1362	aminopeptidase activity
A4V00_RS13700	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
A4V00_RS13720	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4V00_RS13725	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4V00_RS13725	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4V00_RS13730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4V00_RS13745	COG0463	Glycosyl transferase, family 2
A4V00_RS13750	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A4V00_RS13755	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A4V00_RS13765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4V00_RS13770	COG0758	DNA mediated transformation
A4V00_RS13775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4V00_RS13780	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A4V00_RS13790	COG0571	ribonuclease III activity
A4V00_RS13805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4V00_RS13810	COG1196	nuclear chromosome segregation
A4V00_RS13815	COG0552	protein localization to endoplasmic reticulum
A4V00_RS13820	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A4V00_RS13835	COG1713	HD superfamily hydrolase involved in NAD metabolism
A4V00_RS13840	COG0799	negative regulation of ribosome biogenesis
A4V00_RS13845	COG0495	leucyl-tRNA aminoacylation
A4V00_RS13855	COG0577	efflux transmembrane transporter activity
A4V00_RS13860	COG1136	(ABC) transporter
A4V00_RS13865	COG2205	protein histidine kinase activity
A4V00_RS13870	COG0745	RESPONSE REGULATOR receiver
A4V00_RS13875	COG1011	Hydrolase
A4V00_RS13880	COG1649	PFAM Uncharacterised BCR, COG1649
A4V00_RS13885	COG3546	catalase activity
A4V00_RS13925	COG1192	Involved in chromosome partitioning
A4V00_RS13930	COG1475	DNA binding
A4V00_RS13955	COG1131	(ABC) transporter
A4V00_RS14055	COG4509	Sortase family
A4V00_RS14080	COG2205	protein histidine kinase activity
A4V00_RS14085	COG0745	RESPONSE REGULATOR receiver
A4V00_RS14115	COG1733	regulation of RNA biosynthetic process
A4V00_RS14145	COG2337	Toxic component of a toxin-antitoxin (TA) module
A4V00_RS14170	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
A4V00_RS14175	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4V00_RS14180	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A4V00_RS14195	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A4V00_RS14200	COG0124	histidyl-tRNA synthetase
A4V00_RS14205	COG1803	Methylglyoxal synthase
A4V00_RS14210	COG2894	cell division
A4V00_RS14215	COG0768	penicillin binding
A4V00_RS14225	COG1792	Involved in formation and maintenance of cell shape
A4V00_RS14230	COG1077	Cell shape determining protein MreB Mrl
A4V00_RS14240	COG0826	peptidase U32
A4V00_RS14250	COG0058	SHG alpha-glucan phosphorylase activity
A4V00_RS14255	COG0366	Alpha amylase catalytic
A4V00_RS14255	COG3103	Sh3 type 3 domain protein
A4V00_RS14275	COG5632	N-Acetylmuramoyl-L-alanine amidase
A4V00_RS14275	COG3409	Peptidoglycan-binding domain 1 protein
A4V00_RS14340	COG0840	transmembrane signaling receptor activity
A4V00_RS14340	COG5278	phosphoserine phosphatase activity
A4V00_RS14390	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4V00_RS14395	COG0250	Participates in transcription elongation, termination and antitermination
A4V00_RS14400	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A4V00_RS14405	COG0081	regulation of translation
A4V00_RS14415	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A4V00_RS14430	COG3842	ATPase activity
A4V00_RS14435	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4V00_RS14440	COG1177	transmembrane transport
A4V00_RS14445	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A4V00_RS14455	COG1490	D-aminoacyl-tRNA deacylase activity
A4V00_RS14465	COG0561	phosphatase activity
A4V00_RS14485	COG2217	Heavy metal translocating P-type atpase
A4V00_RS14505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4V00_RS14545	COG5002	protein histidine kinase activity
A4V00_RS14565	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4V00_RS14570	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A4V00_RS14580	COG0018	arginyl-trna synthetase
A4V00_RS14595	COG1609	Transcriptional regulator
A4V00_RS14625	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4V00_RS14630	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4V00_RS14645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4V00_RS14660	COG4989	oxidoreductase activity
A4V00_RS14665	COG0268	Binds directly to 16S ribosomal RNA
A4V00_RS14670	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A4V00_RS14675	COG0459	protein refolding
A4V00_RS14690	COG1982	Orn Lys Arg decarboxylase major
A4V00_RS14695	COG0641	radical SAM
A4V00_RS14710	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V00_RS14720	COG0765	amino acid transport
A4V00_RS14725	COG1126	abc transporter atp-binding protein
A4V00_RS14730	COG1473	amidohydrolase
A4V00_RS14735	COG2378	regulation of single-species biofilm formation
A4V00_RS14750	COG0543	2 iron, 2 sulfur cluster binding
A4V00_RS14755	COG0167	dihydroorotate dehydrogenase activity
A4V00_RS14760	COG0406	alpha-ribazole phosphatase activity
A4V00_RS14770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A4V00_RS14775	COG0039	L-malate dehydrogenase activity
A4V00_RS14785	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A4V00_RS14790	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A4V00_RS14795	COG0228	four-way junction DNA binding
A4V00_RS14800	COG1837	Belongs to the UPF0109 family
A4V00_RS14810	COG0336	Belongs to the RNA methyltransferase TrmD family
A4V00_RS14815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4V00_RS14820	COG0322	excinuclease ABC activity
A4V00_RS14825	COG0742	ribosomal rna small subunit methyltransferase
A4V00_RS14840	COG2001	Belongs to the MraZ family
A4V00_RS14845	COG0275	rRNA processing
A4V00_RS14855	COG0768	penicillin binding
A4V00_RS14860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4V00_RS14865	COG0772	Belongs to the SEDS family
A4V00_RS14870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4V00_RS14880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4V00_RS14890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A4V00_RS14900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4V00_RS14910	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A4V00_RS14920	COG0372	Belongs to the citrate synthase family
A4V00_RS14925	COG2385	sporulation resulting in formation of a cellular spore
A4V00_RS14950	COG0673	inositol 2-dehydrogenase activity
A4V00_RS14965	COG1917	Cupin 2, conserved barrel domain protein
A4V00_RS14965	COG1396	sequence-specific DNA binding
A4V00_RS14970	COG1396	sequence-specific DNA binding
A4V00_RS14985	COG1720	tRNA m6t6A37 methyltransferase activity
A4V00_RS14990	COG1120	ATPase activity
A4V00_RS14995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4V00_RS15005	COG0464	growth
A4V00_RS15010	COG0710	3-dehydroquinate dehydratase activity
A4V00_RS15015	COG2337	Toxic component of a toxin-antitoxin (TA) module
A4V00_RS15020	COG0617	tRNA 3'-terminal CCA addition
A4V00_RS15025	COG0653	protein targeting
A4V00_RS15035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4V00_RS15040	COG1164	Oligoendopeptidase f
A4V00_RS15045	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A4V00_RS15050	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A4V00_RS15055	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A4V00_RS15060	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A4V00_RS15075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4V00_RS15080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4V00_RS15085	COG2217	Heavy metal translocating P-type atpase
A4V00_RS15090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4V00_RS15105	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A4V00_RS15115	COG2198	Histidine kinase
A4V00_RS15115	COG0643	Histidine kinase
A4V00_RS15120	COG0835	chemotaxis
A4V00_RS15130	COG2201	protein-glutamate methylesterase activity
A4V00_RS15160	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
A4V00_RS15175	COG1192	Involved in chromosome partitioning
A4V00_RS15185	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A4V00_RS15205	COG2884	Cell division ATP-binding protein ftsE
A4V00_RS15210	COG0840	transmembrane signaling receptor activity
A4V00_RS15225	COG1815	bacterial-type flagellum-dependent cell motility
A4V00_RS15230	COG1558	bacterial-type flagellum-dependent cell motility
A4V00_RS15245	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A4V00_RS15250	COG1317	bacterial-type flagellum organization
A4V00_RS15255	COG1157	protein secretion by the type III secretion system
A4V00_RS15295	COG1360	Flagellar Motor Protein
A4V00_RS15300	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A4V00_RS15305	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A4V00_RS15305	COG1776	CheC inhibitor of MCP methylation
A4V00_RS15310	COG2201	protein-glutamate methylesterase activity
A4V00_RS15315	COG1338	Plays a role in the flagellum-specific transport system
A4V00_RS15315	COG3190	flagellar
A4V00_RS15320	COG1338	Plays a role in the flagellum-specific transport system
A4V00_RS15335	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A4V00_RS15340	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A4V00_RS15345	COG1191	sigma factor activity
A4V00_RS15350	COG4786	Flagellar basal body rod
A4V00_RS15355	COG4786	Flagellar basal body rod
A4V00_RS15360	COG1776	CheC inhibitor of MCP methylation
A4V00_RS15365	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A4V00_RS15370	COG0835	chemotaxis
A4V00_RS15370	COG0784	Response regulator, receiver
A4V00_RS15375	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A4V00_RS15390	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A4V00_RS15390	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A4V00_RS15415	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A4V00_RS15430	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A4V00_RS15445	COG0436	Aminotransferase
A4V00_RS15465	COG0312	modulator of DNA gyrase
A4V00_RS15505	COG0551	DNA topoisomerase type I activity
A4V00_RS15505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4V00_RS15510	COG3681	Belongs to the UPF0597 family
A4V00_RS15530	COG0069	glutamate synthase activity
A4V00_RS15535	COG0067	glutamate synthase
A4V00_RS15545	COG0004	ammonium transporteR
A4V00_RS15550	COG0367	asparagine synthase
A4V00_RS15555	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A4V00_RS15560	COG0613	PHP domain protein
A4V00_RS15570	COG1129	ABC transporter
A4V00_RS15575	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4V00_RS15655	COG4509	Sortase family
A4V00_RS15725	COG3177	Filamentation induced by cAMP protein fic
A4V00_RS15755	COG3254	rhamnose metabolic process
A4V00_RS15780	COG2197	response regulator
A4V00_RS15785	COG2373	Large extracellular alpha-helical protein
A4V00_RS15820	COG1716	ATPase activity
A4V00_RS15820	COG1131	(ABC) transporter
A4V00_RS15820	COG0842	Transport permease protein
A4V00_RS15885	COG4474	Belongs to the UPF0398 family
A4V00_RS15890	COG1191	sigma factor activity
A4V00_RS15910	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A4V00_RS15925	COG0175	sulfate reduction
A4V00_RS15975	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A4V00_RS15980	COG1192	Involved in chromosome partitioning
A4V00_RS15985	COG1475	DNA binding
A4V00_RS16025	COG1136	(ABC) transporter
A4V00_RS16080	COG3293	Transposase
A4V00_RS16135	COG0514	ATP-dependent DNA helicase (RecQ)
A4V00_RS16150	COG1074	ATP-dependent DNA helicase activity
A4V00_RS16195	COG4974	Belongs to the 'phage' integrase family
A4V00_RS16220	COG0573	inorganic phosphate transmembrane transporter activity
A4V00_RS16225	COG0581	inorganic phosphate transmembrane transporter activity
A4V00_RS16230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4V00_RS16245	COG5002	protein histidine kinase activity
A4V00_RS16260	COG1475	DNA binding
A4V00_RS16275	COG0739	heme binding
A4V00_RS16275	COG0741	lytic transglycosylase activity
A4V00_RS16275	COG1196	nuclear chromosome segregation
A4V00_RS16320	COG4974	Belongs to the 'phage' integrase family
A4V00_RS16335	COG2177	Part of the ABC transporter FtsEX involved in
A4V00_RS16340	COG2884	Cell division ATP-binding protein ftsE
A4V00_RS16345	COG2508	Transcriptional regulator
A4V00_RS16375	COG0745	RESPONSE REGULATOR receiver
A4V00_RS16380	COG1486	melibiose metabolic process
A4V00_RS16390	COG0813	purine-nucleoside phosphorylase activity
A4V00_RS16400	COG1136	(ABC) transporter
A4V00_RS16405	COG1368	sulfuric ester hydrolase activity
A4V00_RS16420	COG3192	ethanolamine utilization protein
A4V00_RS16425	COG0006	proline dipeptidase activity
A4V00_RS16430	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A4V00_RS16445	COG1285	pathogenesis
A4V00_RS16455	COG4209	transmembrane transport
A4V00_RS16460	COG0395	ABC-type sugar transport system, permease component
A4V00_RS16470	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A4V00_RS16475	COG2239	Acts as a magnesium transporter
A4V00_RS16480	COG0673	inositol 2-dehydrogenase activity
A4V00_RS16495	COG3906	Belongs to the UPF0473 family
A4V00_RS16505	COG2246	polysaccharide biosynthetic process
A4V00_RS16510	COG1316	TRANSCRIPTIONal
A4V00_RS16515	COG1316	TRANSCRIPTIONal
A4V00_RS16560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A4V00_RS16565	COG4555	ABC transporter
A4V00_RS16595	COG4974	Belongs to the 'phage' integrase family
A4V00_RS16635	COG1475	DNA binding
A4V00_RS16700	COG3843	relaxase mobilization nuclease domain protein
A4V00_RS16735	COG4209	transmembrane transport
A4V00_RS16740	COG0395	ABC-type sugar transport system, permease component
A4V00_RS16780	COG2207	Transcriptional regulator
A4V00_RS16780	COG4753	response regulator
A4V00_RS16785	COG3275	phosphorelay sensor kinase activity
A4V00_RS16795	COG4209	transmembrane transport
A4V00_RS16800	COG0395	ABC-type sugar transport system, permease component
A4V00_RS16805	COG3250	beta-galactosidase activity
A4V00_RS16840	COG0175	sulfate reduction
A4V00_RS16880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4V00_RS16890	COG2184	nucleotidyltransferase activity
A4V00_RS16925	COG4974	Belongs to the 'phage' integrase family
A4V00_RS16965	COG3436	PFAM IS66 Orf2 family protein
A4V00_RS16980	COG4372	Transposase
A4V00_RS16990	COG0191	fructose-bisphosphate aldolase activity
A4V00_RS16995	COG0528	UMP kinase activity
A4V00_RS17000	COG0233	cytoplasmic translational termination
A4V00_RS17010	COG4589	Belongs to the CDS family
A4V00_RS17020	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A4V00_RS17025	COG0750	zinc metalloprotease
A4V00_RS17035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A4V00_RS17050	COG1619	proteins homologs of microcin C7 resistance protein MccF
A4V00_RS17060	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A4V00_RS17065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A4V00_RS17075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4V00_RS17080	COG0131	Imidazoleglycerol-phosphate dehydratase
A4V00_RS17095	COG0140	phosphoribosyl-ATP diphosphatase activity
A4V00_RS17115	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4V00_RS17120	COG0284	orotidine-5'-phosphate decarboxylase activity
A4V00_RS17125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4V00_RS17130	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A4V00_RS17160	COG0151	Belongs to the GarS family
A4V00_RS17170	COG0138	bifunctional purine biosynthesis protein purh
A4V00_RS17185	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A4V00_RS17190	COG2309	aminopeptidase activity
A4V00_RS17195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4V00_RS17205	COG4209	transmembrane transport
A4V00_RS17210	COG0395	ABC-type sugar transport system, permease component
A4V00_RS17220	COG0534	Mate efflux family protein
A4V00_RS17225	COG3958	Transketolase
A4V00_RS17245	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A4V00_RS17265	COG1098	S1 RNA binding domain
A4V00_RS17275	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4V00_RS17280	COG0116	Belongs to the methyltransferase superfamily
A4V00_RS17290	COG0475	glutathione-regulated potassium exporter activity
A4V00_RS17295	COG1695	Transcriptional regulator
A4V00_RS17325	COG0667	Aldo Keto reductase
A4V00_RS17330	COG0583	DNA-binding transcription factor activity
A4V00_RS17340	COG2207	Transcriptional regulator
A4V00_RS17340	COG1917	Cupin 2, conserved barrel domain protein
A4V00_RS17345	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4V00_RS17350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4V00_RS17365	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V00_RS17370	COG1854	S-ribosylhomocysteine lyase activity
A4V00_RS17380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4V00_RS17385	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4V00_RS17405	COG0582	viral genome integration into host DNA
A4V00_RS17410	COG1475	DNA binding
A4V00_RS17490	COG3436	PFAM IS66 Orf2 family protein
A4V00_RS17515	COG1136	(ABC) transporter
A4V00_RS17515	COG0577	efflux transmembrane transporter activity
A4V00_RS17520	COG2205	protein histidine kinase activity
A4V00_RS17525	COG0745	RESPONSE REGULATOR receiver
A4V00_RS17570	COG1132	(ABC) transporter
A4V00_RS17575	COG1132	(ABC) transporter
A4V00_RS17605	COG0642	Histidine kinase
A4V00_RS17605	COG5002	protein histidine kinase activity
A4V00_RS17610	COG0745	RESPONSE REGULATOR receiver
A4V00_RS17635	COG0791	NLP P60 protein
A4V00_RS17635	COG1388	LysM domain
A4V00_RS17705	COG1475	DNA binding
A4V00_RS17760	COG0739	heme binding
A4V00_RS17760	COG0741	lytic transglycosylase activity
A4V00_RS17760	COG1196	nuclear chromosome segregation
A4V00_RS17775	COG0745	RESPONSE REGULATOR receiver
A4V00_RS17790	COG1136	(ABC) transporter
A4V00_RS17830	COG2226	methyltransferase
A4V00_RS17955	COG0740	serine-type endopeptidase activity
A4V00_RS17980	COG0582	viral genome integration into host DNA
A4V00_RS18000	COG2814	Major facilitator Superfamily
A4V00_RS18005	COG4209	transmembrane transport
A4V00_RS18010	COG0395	ABC-type sugar transport system, permease component
A4V00_RS18020	COG1653	transport
A4V00_RS18025	COG0673	inositol 2-dehydrogenase activity
A4V00_RS18135	COG0740	serine-type endopeptidase activity
A4V00_RS18170	COG0583	DNA-binding transcription factor activity
A4V00_RS18175	COG1979	alcohol dehydrogenase
A4V00_RS18230	COG0582	viral genome integration into host DNA
A4V00_RS18235	COG0583	DNA-binding transcription factor activity
A4V00_RS18240	COG1979	alcohol dehydrogenase
A4V00_RS18265	COG0582	viral genome integration into host DNA
A4V00_RS18290	COG0772	Belongs to the SEDS family
A4V00_RS18295	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A4V00_RS18310	COG0698	ribose 5-phosphate isomerase
A4V00_RS18315	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A4V00_RS18325	COG0612	Peptidase, M16
A4V00_RS18330	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A4V00_RS18335	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A4V00_RS18340	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4V00_RS18345	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A4V00_RS18350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A4V00_RS18355	COG1438	arginine binding
A4V00_RS18360	COG0497	DNA recombination
A4V00_RS18370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A4V00_RS18380	COG0527	aspartate kinase activity
A4V00_RS18385	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A4V00_RS18390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4V00_RS18430	COG1373	ATPase (AAA superfamily
A4V00_RS18455	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A4V00_RS18465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4V00_RS18470	COG0352	thiamine-phosphate diphosphorylase activity
A4V00_RS18470	COG0351	phosphomethylpyrimidine kinase
A4V00_RS18475	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A4V00_RS18485	COG3620	sequence-specific DNA binding
A4V00_RS18495	COG1131	(ABC) transporter
A4V00_RS18505	COG1131	(ABC) transporter
A4V00_RS18530	COG1309	transcriptional regulator
A4V00_RS18535	COG0028	Belongs to the TPP enzyme family
A4V00_RS18540	COG0440	acetolactate synthase activity
A4V00_RS18570	COG0745	RESPONSE REGULATOR receiver
A4V00_RS18575	COG2205	protein histidine kinase activity
A4V00_RS18600	COG1129	ABC transporter
A4V00_RS18600	COG0842	Transport permease protein
A4V00_RS18640	COG0745	RESPONSE REGULATOR receiver
A4V00_RS18655	COG1131	(ABC) transporter
A4V00_RS18660	COG0789	Transcriptional regulator
A4V00_RS18665	COG1131	(ABC) transporter
A4V00_RS18680	COG2205	protein histidine kinase activity
A4V00_RS18685	COG0745	RESPONSE REGULATOR receiver
A4V00_RS18715	COG1373	ATPase (AAA superfamily
A4V00_RS18720	COG1309	transcriptional regulator
A4V00_RS18870	COG0270	DNA (cytosine-5-)-methyltransferase activity
A4V00_RS18885	COG3293	Transposase
A4V00_RS18900	COG2207	Transcriptional regulator
A4V00_RS18900	COG0662	Cupin 2, conserved barrel domain protein
A4V00_RS18920	COG0395	ABC-type sugar transport system, permease component
A4V00_RS18925	COG4209	transmembrane transport
A4V00_RS18930	COG3119	arylsulfatase activity
A4V00_RS18970	COG0582	viral genome integration into host DNA
A4V00_RS18985	COG1132	(ABC) transporter
A4V00_RS19050	COG3681	Belongs to the UPF0597 family
A4V00_RS19055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4V00_RS19065	COG0492	ferredoxin-NADP+ reductase activity
A4V00_RS19075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V00_RS19085	COG1132	(ABC) transporter
A4V00_RS19090	COG1132	(ABC) transporter
A4V00_RS19130	COG0582	viral genome integration into host DNA
A4V00_RS19145	COG1695	Transcriptional regulator
A4V00_RS19165	COG1131	(ABC) transporter
A4V00_RS19245	COG0582	viral genome integration into host DNA
A4V00_RS19260	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A4V00_RS19265	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A4V00_RS19280	COG1481	regulation of sporulation
A4V00_RS19305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4V00_RS19310	COG0424	maF-like protein
A4V00_RS19330	COG2323	membrane
A4V00_RS19335	COG0697	spore germination
A4V00_RS19350	COG0367	asparagine synthase
A4V00_RS19380	COG0210	DNA helicase
A4V00_RS19385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4V00_RS19400	COG1132	(ABC) transporter
A4V00_RS19405	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4V00_RS19410	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A4V00_RS19485	COG4509	Sortase family
A4V00_RS19540	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat