locus-tag	class	description
HYDSHO_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HYDSHO_RS00015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYDSHO_RS00015	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYDSHO_RS00020	COG0297	glycogen (starch) synthase activity
HYDSHO_RS00025	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HYDSHO_RS00030	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HYDSHO_RS00045	COG1136	(ABC) transporter
HYDSHO_RS00050	COG1136	(ABC) transporter
HYDSHO_RS00050	COG0577	efflux transmembrane transporter activity
HYDSHO_RS00065	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HYDSHO_RS00070	COG0704	Plays a role in the regulation of phosphate uptake
HYDSHO_RS00075	COG5000	phosphorelay sensor kinase activity
HYDSHO_RS00105	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HYDSHO_RS00110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HYDSHO_RS00120	COG1187	pseudouridine synthase activity
HYDSHO_RS00125	COG0302	gtp cyclohydrolase
HYDSHO_RS00130	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HYDSHO_RS00135	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HYDSHO_RS00145	COG0484	heat shock protein binding
HYDSHO_RS00150	COG0789	Transcriptional regulator
HYDSHO_RS00160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HYDSHO_RS00165	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HYDSHO_RS00170	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HYDSHO_RS00190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HYDSHO_RS00200	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HYDSHO_RS00205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYDSHO_RS00220	COG1144	Oxidoreductase
HYDSHO_RS00230	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYDSHO_RS00255	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HYDSHO_RS00260	COG0375	protein maturation
HYDSHO_RS00275	COG0298	carbon dioxide binding
HYDSHO_RS00280	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HYDSHO_RS00285	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HYDSHO_RS00320	COG1331	Highly conserved protein containing a thioredoxin domain
HYDSHO_RS00335	COG3956	TIGRFAM MazG family protein
HYDSHO_RS00345	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HYDSHO_RS00355	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HYDSHO_RS00365	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HYDSHO_RS00375	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HYDSHO_RS00380	COG1090	epimerase
HYDSHO_RS00385	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HYDSHO_RS00395	COG0746	molybdenum cofactor guanylyltransferase activity
HYDSHO_RS00400	COG0741	lytic transglycosylase activity
HYDSHO_RS00400	COG1388	LysM domain
HYDSHO_RS00405	COG1450	Type ii and iii secretion system protein
HYDSHO_RS00410	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HYDSHO_RS00415	COG0758	DNA mediated transformation
HYDSHO_RS00445	COG3842	ATPase activity
HYDSHO_RS00450	COG4535	Mg2 and Co2 transporter CorC
HYDSHO_RS00455	COG1040	competence protein
HYDSHO_RS00460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYDSHO_RS00465	COG0138	bifunctional purine biosynthesis protein purh
HYDSHO_RS00490	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HYDSHO_RS00495	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HYDSHO_RS00505	COG1509	lysine 2,3-aminomutase activity
HYDSHO_RS00525	COG3604	Transcriptional regulator
HYDSHO_RS00550	COG3177	Filamentation induced by cAMP protein fic
HYDSHO_RS00565	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HYDSHO_RS00580	COG0776	regulation of translation
HYDSHO_RS00595	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HYDSHO_RS00600	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HYDSHO_RS00605	COG1309	transcriptional regulator
HYDSHO_RS00615	COG0133	tryptophan synthase activity
HYDSHO_RS00625	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HYDSHO_RS00630	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HYDSHO_RS00635	COG0802	atpase or kinase
HYDSHO_RS00650	COG0336	Belongs to the RNA methyltransferase TrmD family
HYDSHO_RS00660	COG1605	Chorismate mutase
HYDSHO_RS00660	COG0077	Prephenate dehydratase
HYDSHO_RS00670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYDSHO_RS00675	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYDSHO_RS00685	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HYDSHO_RS00690	COG0305	Participates in initiation and elongation during chromosome replication
HYDSHO_RS00700	COG0174	glutamine synthetase
HYDSHO_RS00705	COG0347	Belongs to the P(II) protein family
HYDSHO_RS00710	COG0315	cyclic pyranopterin monophosphate synthase activity
HYDSHO_RS00715	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HYDSHO_RS00730	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYDSHO_RS00735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HYDSHO_RS00755	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HYDSHO_RS00760	COG1185	polyribonucleotide nucleotidyltransferase activity
HYDSHO_RS00765	COG0756	dUTP diphosphatase activity
HYDSHO_RS00770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HYDSHO_RS00780	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HYDSHO_RS00785	COG0740	serine-type endopeptidase activity
HYDSHO_RS00790	COG0544	peptidyl-prolyl cis-trans isomerase activity
HYDSHO_RS00800	COG0251	oxidation-reduction process
HYDSHO_RS00805	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HYDSHO_RS00815	COG4178	(ABC) transporter
HYDSHO_RS00820	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HYDSHO_RS00825	COG4786	Flagellar basal body rod
HYDSHO_RS00835	COG4968	Prepilin-type N-terminal cleavage methylation domain
HYDSHO_RS00845	COG0165	Argininosuccinate lyase
HYDSHO_RS00855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYDSHO_RS00860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HYDSHO_RS00865	COG2222	sugar isomerase
HYDSHO_RS00870	COG1254	Belongs to the acylphosphatase family
HYDSHO_RS00880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HYDSHO_RS00885	COG0517	IMP dehydrogenase activity
HYDSHO_RS00885	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HYDSHO_RS00890	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYDSHO_RS00900	COG1815	bacterial-type flagellum-dependent cell motility
HYDSHO_RS00910	COG1558	bacterial-type flagellum-dependent cell motility
HYDSHO_RS00915	COG1677	Flagellar hook-basal body complex protein FliE
HYDSHO_RS00920	COG1766	The M ring may be actively involved in energy transduction
HYDSHO_RS00930	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYDSHO_RS00935	COG1105	Belongs to the carbohydrate kinase PfkB family
HYDSHO_RS00955	COG1127	ABC transporter
HYDSHO_RS00960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HYDSHO_RS00995	COG3039	Transposase
HYDSHO_RS01000	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HYDSHO_RS01005	COG0517	IMP dehydrogenase activity
HYDSHO_RS01005	COG0516	GMP reductase activity
HYDSHO_RS01010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYDSHO_RS01015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYDSHO_RS01035	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HYDSHO_RS01050	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HYDSHO_RS01060	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HYDSHO_RS01065	COG3300	MHYT domain
HYDSHO_RS01065	COG5001	Diguanylate cyclase
HYDSHO_RS01070	COG2199	diguanylate cyclase activity
HYDSHO_RS01070	COG2200	EAL domain
HYDSHO_RS01085	COG0772	Belongs to the SEDS family
HYDSHO_RS01090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYDSHO_RS01100	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HYDSHO_RS01105	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HYDSHO_RS01110	COG0129	dihydroxy-acid dehydratase activity
HYDSHO_RS01115	COG0343	queuine tRNA-ribosyltransferase activity
HYDSHO_RS01125	COG0710	3-dehydroquinate dehydratase activity
HYDSHO_RS01130	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HYDSHO_RS01140	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HYDSHO_RS01170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYDSHO_RS01175	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HYDSHO_RS01185	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HYDSHO_RS01190	COG0416	fatty acid biosynthetic process
HYDSHO_RS01195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYDSHO_RS01205	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HYDSHO_RS01210	COG0248	Ppx GppA phosphatase
HYDSHO_RS01220	COG0714	Associated with various cellular activities
HYDSHO_RS01235	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HYDSHO_RS01245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HYDSHO_RS01250	COG1110	DNA topoisomerase II activity
HYDSHO_RS01255	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HYDSHO_RS01275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYDSHO_RS01290	COG0250	Participates in transcription elongation, termination and antitermination
HYDSHO_RS01295	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HYDSHO_RS01300	COG0081	regulation of translation
HYDSHO_RS01305	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HYDSHO_RS01310	COG0222	ribosome binding
HYDSHO_RS01315	COG0085	RNA polymerase activity
HYDSHO_RS01320	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HYDSHO_RS01320	COG0433	COG0433 Predicted ATPase
HYDSHO_RS01325	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HYDSHO_RS01330	COG0049	tRNA binding
HYDSHO_RS01335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYDSHO_RS01340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYDSHO_RS01345	COG0051	transcription antitermination factor activity, RNA binding
HYDSHO_RS01350	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HYDSHO_RS01355	COG0088	Forms part of the polypeptide exit tunnel
HYDSHO_RS01360	COG0089	rRNA binding
HYDSHO_RS01365	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HYDSHO_RS01370	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HYDSHO_RS01375	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HYDSHO_RS01380	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HYDSHO_RS01385	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HYDSHO_RS01390	COG0255	Belongs to the universal ribosomal protein uL29 family
HYDSHO_RS01395	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HYDSHO_RS01400	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HYDSHO_RS01405	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HYDSHO_RS01410	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HYDSHO_RS01415	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HYDSHO_RS01420	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HYDSHO_RS01425	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HYDSHO_RS01430	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HYDSHO_RS01435	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HYDSHO_RS01440	COG1841	ribosomal large subunit assembly
HYDSHO_RS01445	COG0200	Binds to the 23S rRNA
HYDSHO_RS01450	COG0201	protein transport
HYDSHO_RS01455	COG0563	adenylate kinase activity
HYDSHO_RS01460	COG0024	Methionine aminopeptidase
HYDSHO_RS01465	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HYDSHO_RS01470	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HYDSHO_RS01475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HYDSHO_RS01480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HYDSHO_RS01485	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HYDSHO_RS01490	COG0202	RNA polymerase activity
HYDSHO_RS01495	COG0203	ribosomal protein L17
HYDSHO_RS01500	COG0762	integral membrane protein
HYDSHO_RS01505	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HYDSHO_RS01510	COG0228	four-way junction DNA binding
HYDSHO_RS01515	COG1837	Belongs to the UPF0109 family
HYDSHO_RS01525	COG0351	phosphomethylpyrimidine kinase
HYDSHO_RS01530	COG1137	ATPase activity
HYDSHO_RS01550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HYDSHO_RS01555	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HYDSHO_RS01560	COG0243	molybdopterin cofactor binding
HYDSHO_RS01585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYDSHO_RS01590	COG0243	molybdopterin cofactor binding
HYDSHO_RS01600	COG2204	response regulator
HYDSHO_RS01605	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HYDSHO_RS01630	COG0540	Belongs to the ATCase OTCase family
HYDSHO_RS01640	COG1496	oxidoreductase activity
HYDSHO_RS01645	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HYDSHO_RS01660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HYDSHO_RS01675	COG0612	Peptidase, M16
HYDSHO_RS01695	COG1309	transcriptional regulator
HYDSHO_RS01705	COG0511	ligase activity, forming carbon-carbon bonds
HYDSHO_RS01710	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HYDSHO_RS01720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYDSHO_RS01725	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYDSHO_RS01735	COG1550	Protein conserved in bacteria
HYDSHO_RS01745	COG0482	sulfurtransferase activity
HYDSHO_RS01755	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HYDSHO_RS01765	COG0697	spore germination
HYDSHO_RS01775	COG0698	ribose 5-phosphate isomerase
HYDSHO_RS01780	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYDSHO_RS01785	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYDSHO_RS01790	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HYDSHO_RS01795	COG0131	Imidazoleglycerol-phosphate dehydratase
HYDSHO_RS01805	COG1077	Cell shape determining protein MreB Mrl
HYDSHO_RS01825	COG1999	signal sequence binding
HYDSHO_RS01835	COG0745	RESPONSE REGULATOR receiver
HYDSHO_RS01840	COG2205	protein histidine kinase activity
HYDSHO_RS01840	COG0784	Response regulator, receiver
HYDSHO_RS01845	COG0628	permease
HYDSHO_RS01850	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HYDSHO_RS01855	COG0180	Tryptophanyl-tRNA synthetase
HYDSHO_RS01860	COG1994	Peptidase M50
HYDSHO_RS01875	COG2050	protein possibly involved in aromatic compounds catabolism
HYDSHO_RS01875	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HYDSHO_RS01890	COG2201	protein-glutamate methylesterase activity
HYDSHO_RS01895	COG1968	undecaprenyl-diphosphatase activity
HYDSHO_RS01910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HYDSHO_RS01915	COG0811	peptide transport
HYDSHO_RS01920	COG0848	biopolymer transport protein
HYDSHO_RS01930	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HYDSHO_RS01930	COG0316	Belongs to the HesB IscA family
HYDSHO_RS01940	COG0425	Belongs to the sulfur carrier protein TusA family
HYDSHO_RS01950	COG0822	iron-sulfur transferase activity
HYDSHO_RS01955	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HYDSHO_RS01960	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HYDSHO_RS01970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HYDSHO_RS01990	COG0018	arginyl-trna synthetase
HYDSHO_RS02020	COG1518	maintenance of DNA repeat elements
HYDSHO_RS02040	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HYDSHO_RS02045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYDSHO_RS02055	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HYDSHO_RS02080	COG0284	orotidine-5'-phosphate decarboxylase activity
HYDSHO_RS02090	COG0445	tRNA wobble uridine modification
HYDSHO_RS02100	COG0436	Aminotransferase
HYDSHO_RS02105	COG1489	DNA binding
HYDSHO_RS02115	COG0438	transferase activity, transferring glycosyl groups
HYDSHO_RS02130	COG0668	transmembrane transport
HYDSHO_RS02135	COG2860	membrane
HYDSHO_RS02140	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HYDSHO_RS02145	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HYDSHO_RS02150	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HYDSHO_RS02170	COG0066	3-isopropylmalate dehydratase activity
HYDSHO_RS02175	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HYDSHO_RS02185	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HYDSHO_RS02190	COG0107	imidazoleglycerol-phosphate synthase activity
HYDSHO_RS02200	COG1276	copper resistance
HYDSHO_RS02205	COG0359	binds to the 23S rRNA
HYDSHO_RS02210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HYDSHO_RS02215	COG0629	single-stranded DNA binding
HYDSHO_RS02220	COG0360	Binds together with S18 to 16S ribosomal RNA
HYDSHO_RS02235	COG1136	(ABC) transporter
HYDSHO_RS02240	COG2067	long-chain fatty acid transport protein
HYDSHO_RS02250	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HYDSHO_RS02260	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HYDSHO_RS02265	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HYDSHO_RS02270	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HYDSHO_RS02275	COG1199	ATP-dependent helicase activity
HYDSHO_RS02275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HYDSHO_RS02280	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HYDSHO_RS02295	COG1294	oxidase, subunit
HYDSHO_RS02300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HYDSHO_RS02305	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HYDSHO_RS02315	COG0537	adenosine 5'-monophosphoramidase activity
HYDSHO_RS02325	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HYDSHO_RS02325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYDSHO_RS02330	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HYDSHO_RS02340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYDSHO_RS02360	COG0179	Fumarylacetoacetate (FAA) hydrolase
HYDSHO_RS02365	COG1196	nuclear chromosome segregation
HYDSHO_RS02370	COG0137	argininosuccinate synthase activity
HYDSHO_RS02380	COG0436	Aminotransferase
HYDSHO_RS02385	COG2835	tetraacyldisaccharide 4'-kinase activity
HYDSHO_RS02395	COG1160	GTP binding
HYDSHO_RS02400	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HYDSHO_RS02405	COG0242	peptide deformylase activity
HYDSHO_RS02420	COG0114	fumarate hydratase activity
HYDSHO_RS02425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HYDSHO_RS02445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HYDSHO_RS02455	COG0217	transcriptional regulatory protein
HYDSHO_RS02460	COG1349	DNA-binding transcription factor activity
HYDSHO_RS02475	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HYDSHO_RS02475	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HYDSHO_RS02480	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HYDSHO_RS02490	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HYDSHO_RS02495	COG1028	Short-chain dehydrogenase reductase Sdr
HYDSHO_RS02500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYDSHO_RS02505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYDSHO_RS02510	COG0571	ribonuclease III activity
HYDSHO_RS02525	COG0012	GTP binding
HYDSHO_RS02530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYDSHO_RS02535	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HYDSHO_RS02540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYDSHO_RS02545	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HYDSHO_RS02555	COG0736	holo-[acyl-carrier-protein] synthase activity
HYDSHO_RS02560	COG0019	diaminopimelate decarboxylase activity
HYDSHO_RS02570	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HYDSHO_RS02575	COG0277	FAD linked oxidase domain protein
HYDSHO_RS02585	COG1459	type II secretion system
HYDSHO_RS02630	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYDSHO_RS02635	COG0156	8-amino-7-oxononanoate synthase activity
HYDSHO_RS02650	COG0601	transmembrane transport
HYDSHO_RS02655	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYDSHO_RS02660	COG0531	amino acid
HYDSHO_RS02665	COG1012	belongs to the aldehyde dehydrogenase family
HYDSHO_RS02670	COG0113	porphobilinogen synthase activity
HYDSHO_RS02680	COG3002	Belongs to the UPF0753 family
HYDSHO_RS02685	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HYDSHO_RS02690	COG0402	S-adenosylhomocysteine deaminase activity
HYDSHO_RS02695	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HYDSHO_RS02705	COG1484	DNA-dependent DNA replication
HYDSHO_RS02710	COG2814	Major facilitator Superfamily
HYDSHO_RS02715	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HYDSHO_RS02720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HYDSHO_RS02740	COG0047	phosphoribosylformylglycinamidine synthase activity
HYDSHO_RS02745	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HYDSHO_RS02750	COG0717	Belongs to the dCTP deaminase family
HYDSHO_RS02760	COG0124	histidyl-tRNA synthetase
HYDSHO_RS02765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYDSHO_RS02765	COG2146	nitrite reductase [NAD(P)H] activity
HYDSHO_RS02770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HYDSHO_RS02775	COG0436	Aminotransferase
HYDSHO_RS02785	COG0840	transmembrane signaling receptor activity
HYDSHO_RS02790	COG2095	MarC family integral membrane protein
HYDSHO_RS02815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYDSHO_RS02820	COG0640	Transcriptional regulator
HYDSHO_RS02835	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HYDSHO_RS02860	COG1993	acr, cog1993
HYDSHO_RS02865	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HYDSHO_RS02870	COG0651	ATP synthesis coupled electron transport
HYDSHO_RS02880	COG0649	NAD binding
HYDSHO_RS02885	COG0651	ATP synthesis coupled electron transport
HYDSHO_RS02900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HYDSHO_RS02905	COG0463	Glycosyl transferase, family 2
HYDSHO_RS02910	COG0484	heat shock protein binding
HYDSHO_RS02920	COG1706	bacterial-type flagellum-dependent cell motility
HYDSHO_RS02925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HYDSHO_RS02930	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HYDSHO_RS02935	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HYDSHO_RS02940	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HYDSHO_RS02945	COG0083	homoserine kinase activity
HYDSHO_RS02955	COG0425	Belongs to the sulfur carrier protein TusA family
HYDSHO_RS02960	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYDSHO_RS02985	COG0039	L-malate dehydrogenase activity
HYDSHO_RS02995	COG1980	fructose-bisphosphate aldolase activity
HYDSHO_RS03010	COG2814	Major facilitator Superfamily
HYDSHO_RS03020	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HYDSHO_RS03025	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HYDSHO_RS03030	COG0457	Tetratricopeptide repeat
HYDSHO_RS03030	COG0552	protein localization to endoplasmic reticulum
HYDSHO_RS03055	COG3118	belongs to the thioredoxin family
HYDSHO_RS03060	COG0492	ferredoxin-NADP+ reductase activity
HYDSHO_RS03065	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HYDSHO_RS03075	COG1530	ribonuclease E activity
HYDSHO_RS03080	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HYDSHO_RS03105	COG0511	ligase activity, forming carbon-carbon bonds
HYDSHO_RS03105	COG5016	pyruvate
HYDSHO_RS03110	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HYDSHO_RS03115	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HYDSHO_RS03125	COG1053	succinate dehydrogenase
HYDSHO_RS03140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HYDSHO_RS03150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HYDSHO_RS03160	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HYDSHO_RS03170	COG0123	including yeast histone deacetylase and acetoin utilization protein
HYDSHO_RS03175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYDSHO_RS03180	COG0519	Catalyzes the synthesis of GMP from XMP
HYDSHO_RS03180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HYDSHO_RS03185	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HYDSHO_RS03195	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYDSHO_RS03205	COG1157	protein secretion by the type III secretion system
HYDSHO_RS03220	COG1749	Flagellar hook protein flgE
HYDSHO_RS03225	COG1580	Controls the rotational direction of flagella during chemotaxis
HYDSHO_RS03235	COG1338	Plays a role in the flagellum-specific transport system
HYDSHO_RS03240	COG1987	bacterial-type flagellum assembly
HYDSHO_RS03245	COG1684	flagellar biosynthetic protein fliR
HYDSHO_RS03250	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYDSHO_RS03255	COG0602	queuosine metabolic process
HYDSHO_RS03260	COG0328	RNA-DNA hybrid ribonuclease activity
HYDSHO_RS03295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HYDSHO_RS03355	COG0542	response to heat
HYDSHO_RS03360	COG0826	peptidase U32
HYDSHO_RS03365	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HYDSHO_RS03375	COG1260	myo-inositol-1-phosphate synthase
HYDSHO_RS03380	COG0237	dephospho-CoA kinase activity
HYDSHO_RS03385	COG1217	gtp-binding protein TYPA
HYDSHO_RS03390	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HYDSHO_RS03395	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HYDSHO_RS03415	COG0095	Lipoate-protein ligase
HYDSHO_RS03430	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HYDSHO_RS03435	COG0442	prolyl-tRNA aminoacylation
HYDSHO_RS03450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HYDSHO_RS03455	COG0793	Belongs to the peptidase S41A family
HYDSHO_RS03455	COG3409	Peptidoglycan-binding domain 1 protein
HYDSHO_RS03480	COG0438	transferase activity, transferring glycosyl groups
HYDSHO_RS03515	COG0811	peptide transport
HYDSHO_RS03520	COG0848	biopolymer transport protein
HYDSHO_RS03570	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HYDSHO_RS03630	COG2805	Type II/IV secretion system protein
HYDSHO_RS03655	COG0778	Nitroreductase
HYDSHO_RS03665	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HYDSHO_RS03665	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HYDSHO_RS03670	COG0126	phosphoglycerate kinase activity
HYDSHO_RS03675	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HYDSHO_RS03680	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HYDSHO_RS03695	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HYDSHO_RS03700	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
HYDSHO_RS03705	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYDSHO_RS03710	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYDSHO_RS03715	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYDSHO_RS03715	COG0649	NAD binding
HYDSHO_RS03720	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HYDSHO_RS03725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYDSHO_RS03730	COG0839	Belongs to the complex I subunit 6 family
HYDSHO_RS03735	COG0713	ATP synthesis coupled electron transport
HYDSHO_RS03745	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYDSHO_RS03750	COG1007	ATP synthesis coupled electron transport
HYDSHO_RS03755	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYDSHO_RS03760	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYDSHO_RS03760	COG0649	NAD binding
HYDSHO_RS03765	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HYDSHO_RS03770	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYDSHO_RS03775	COG0839	Belongs to the complex I subunit 6 family
HYDSHO_RS03780	COG0713	ATP synthesis coupled electron transport
HYDSHO_RS03790	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYDSHO_RS03795	COG1007	ATP synthesis coupled electron transport
HYDSHO_RS03800	COG0194	GDP metabolic process
HYDSHO_RS03805	COG1758	RNA polymerase activity
HYDSHO_RS03810	COG0612	Peptidase, M16
HYDSHO_RS03815	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HYDSHO_RS03835	COG0419	ATPase involved in DNA repair
HYDSHO_RS03845	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HYDSHO_RS03850	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HYDSHO_RS03855	COG4641	Protein conserved in bacteria
HYDSHO_RS03860	COG1663	tetraacyldisaccharide 4'-kinase activity
HYDSHO_RS03870	COG0439	Biotin carboxylase
HYDSHO_RS03875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HYDSHO_RS03880	COG0497	DNA recombination
HYDSHO_RS03885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYDSHO_RS03895	COG2264	protein methyltransferase activity
HYDSHO_RS03905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HYDSHO_RS03910	COG0527	aspartate kinase activity
HYDSHO_RS03915	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HYDSHO_RS03915	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HYDSHO_RS03945	COG2814	Major facilitator Superfamily
HYDSHO_RS03950	COG2154	pterin-4-alpha-carbinolamine dehydratase
HYDSHO_RS03955	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HYDSHO_RS03970	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HYDSHO_RS03975	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HYDSHO_RS03980	COG1449	Belongs to the glycosyl hydrolase 57 family
HYDSHO_RS03990	COG5002	protein histidine kinase activity
HYDSHO_RS03995	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HYDSHO_RS04000	COG1862	Preprotein translocase
HYDSHO_RS04005	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HYDSHO_RS04015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYDSHO_RS04020	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HYDSHO_RS04025	COG2890	protein-(glutamine-N5) methyltransferase activity
HYDSHO_RS04030	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HYDSHO_RS04035	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
HYDSHO_RS04045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HYDSHO_RS04050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HYDSHO_RS04060	COG0495	leucyl-tRNA aminoacylation
HYDSHO_RS04065	COG5002	protein histidine kinase activity
HYDSHO_RS04065	COG5001	Diguanylate cyclase
HYDSHO_RS04085	COG3278	Belongs to the heme-copper respiratory oxidase family
HYDSHO_RS04115	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HYDSHO_RS04120	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HYDSHO_RS04130	COG0606	chelatase, subunit chli
HYDSHO_RS04145	COG0556	nucleotide-excision repair
HYDSHO_RS04150	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HYDSHO_RS04155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYDSHO_RS04160	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HYDSHO_RS04200	COG0824	Thioesterase
HYDSHO_RS04205	COG0735	belongs to the Fur family
HYDSHO_RS04215	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HYDSHO_RS04225	COG3634	alkyl hydroperoxide reductase activity
HYDSHO_RS04230	COG0307	riboflavin synthase, alpha
HYDSHO_RS04245	COG1566	PFAM secretion protein HlyD family protein
HYDSHO_RS04250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYDSHO_RS04255	COG1546	Belongs to the CinA family
HYDSHO_RS04255	COG1058	Belongs to the CinA family
HYDSHO_RS04260	COG0768	penicillin binding
HYDSHO_RS04270	COG0275	rRNA processing
HYDSHO_RS04275	COG0123	including yeast histone deacetylase and acetoin utilization protein
HYDSHO_RS04280	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HYDSHO_RS04290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HYDSHO_RS04295	COG0459	protein refolding
HYDSHO_RS04300	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HYDSHO_RS04305	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HYDSHO_RS04310	COG0140	phosphoribosyl-ATP diphosphatase activity
HYDSHO_RS04310	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HYDSHO_RS04315	COG0316	Belongs to the HesB IscA family
HYDSHO_RS04345	COG1334	flagellar protein FlaG
HYDSHO_RS04350	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HYDSHO_RS04355	COG0072	phenylalanine-tRNA ligase activity
HYDSHO_RS04355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYDSHO_RS04360	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HYDSHO_RS04365	COG1418	mRNA catabolic process
HYDSHO_RS04365	COG3599	regulation of cell shape
HYDSHO_RS04370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYDSHO_RS04375	COG0356	it plays a direct role in the translocation of protons across the membrane
HYDSHO_RS04385	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HYDSHO_RS04395	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HYDSHO_RS04400	COG0706	membrane insertase activity
HYDSHO_RS04405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYDSHO_RS04410	COG1465	3-dehydroquinate synthase
HYDSHO_RS04415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HYDSHO_RS04420	COG0436	Aminotransferase
HYDSHO_RS04425	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HYDSHO_RS04435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HYDSHO_RS04440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYDSHO_RS04445	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HYDSHO_RS04455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HYDSHO_RS04460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HYDSHO_RS04475	COG0247	lactate metabolic process
HYDSHO_RS04480	COG1592	Rubrerythrin
HYDSHO_RS04505	COG2165	general secretion pathway protein
HYDSHO_RS04515	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYDSHO_RS04525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HYDSHO_RS04545	COG0142	geranyltranstransferase activity
HYDSHO_RS04580	COG0730	response to heat
HYDSHO_RS04605	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HYDSHO_RS04610	COG0045	succinate-CoA ligase (ADP-forming) activity
HYDSHO_RS04615	COG1278	Cold shock
HYDSHO_RS04620	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HYDSHO_RS04625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYDSHO_RS04630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYDSHO_RS04640	COG0095	Lipoate-protein ligase
HYDSHO_RS04645	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYDSHO_RS04650	COG1355	regulation of microtubule-based process
HYDSHO_RS04660	COG0347	Belongs to the P(II) protein family
HYDSHO_RS04665	COG0004	ammonium transporteR
HYDSHO_RS04690	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HYDSHO_RS04725	COG0157	Belongs to the NadC ModD family
HYDSHO_RS04735	COG0505	Belongs to the CarA family
HYDSHO_RS04750	COG0193	aminoacyl-tRNA hydrolase activity
HYDSHO_RS04755	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HYDSHO_RS04760	COG0357	Ribosomal RNA small subunit methyltransferase G
HYDSHO_RS04790	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HYDSHO_RS04795	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HYDSHO_RS04805	COG0811	peptide transport
HYDSHO_RS04815	COG0406	alpha-ribazole phosphatase activity
HYDSHO_RS04820	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HYDSHO_RS04825	COG0105	UTP biosynthetic process
HYDSHO_RS04835	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYDSHO_RS04845	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HYDSHO_RS04855	COG1028	Short-chain dehydrogenase reductase Sdr
HYDSHO_RS04860	COG0438	transferase activity, transferring glycosyl groups
HYDSHO_RS04865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYDSHO_RS04875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HYDSHO_RS04885	COG2149	membrane
HYDSHO_RS04890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HYDSHO_RS04900	COG2814	Major facilitator Superfamily
HYDSHO_RS04920	COG1832	CoA-binding protein
HYDSHO_RS04925	COG0653	protein targeting
HYDSHO_RS04930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYDSHO_RS04945	COG1458	PINc domain ribonuclease
HYDSHO_RS04960	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HYDSHO_RS04965	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HYDSHO_RS04970	COG0590	tRNA wobble adenosine to inosine editing
HYDSHO_RS04975	COG0432	Pfam Uncharacterised protein family UPF0047
HYDSHO_RS04980	COG0750	zinc metalloprotease
HYDSHO_RS04985	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HYDSHO_RS04990	COG1132	(ABC) transporter
HYDSHO_RS05000	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HYDSHO_RS05005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HYDSHO_RS05010	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HYDSHO_RS05035	COG5002	protein histidine kinase activity
HYDSHO_RS05040	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HYDSHO_RS05050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HYDSHO_RS05055	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HYDSHO_RS05070	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HYDSHO_RS05075	COG0557	exoribonuclease II activity
HYDSHO_RS05090	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HYDSHO_RS05105	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HYDSHO_RS05110	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HYDSHO_RS05120	COG0825	malonyl-CoA metabolic process
HYDSHO_RS05125	COG0551	DNA topoisomerase type I activity
HYDSHO_RS05125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HYDSHO_RS05130	COG0745	RESPONSE REGULATOR receiver
HYDSHO_RS05140	COG0312	modulator of DNA gyrase
HYDSHO_RS05170	COG0483	inositol monophosphate 1-phosphatase activity
HYDSHO_RS05185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HYDSHO_RS05205	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HYDSHO_RS05210	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HYDSHO_RS05215	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HYDSHO_RS05220	COG0335	large ribosomal subunit rRNA binding
HYDSHO_RS05230	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HYDSHO_RS05235	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HYDSHO_RS05240	COG0157	Belongs to the NadC ModD family
HYDSHO_RS05245	COG0776	regulation of translation
HYDSHO_RS05255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HYDSHO_RS05270	COG0495	leucyl-tRNA aminoacylation
HYDSHO_RS05285	COG1144	Oxidoreductase
HYDSHO_RS05295	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HYDSHO_RS05305	COG0515	serine threonine protein kinase
HYDSHO_RS05305	COG2815	serine threonine protein kinase
HYDSHO_RS05310	COG0101	tRNA pseudouridine synthase activity
HYDSHO_RS05315	COG0058	SHG alpha-glucan phosphorylase activity
HYDSHO_RS05335	COG0493	'glutamate synthase
HYDSHO_RS05355	COG0509	glycine decarboxylation via glycine cleavage system
HYDSHO_RS05370	COG0509	glycine decarboxylation via glycine cleavage system
HYDSHO_RS05390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYDSHO_RS05410	COG2210	Belongs to the sulfur carrier protein TusA family
HYDSHO_RS05415	COG0425	Belongs to the sulfur carrier protein TusA family
HYDSHO_RS05425	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HYDSHO_RS05430	COG0592	DNA-directed DNA polymerase activity
HYDSHO_RS05440	COG0420	3'-5' exonuclease activity
HYDSHO_RS05445	COG0330	HflC and HflK could
HYDSHO_RS05455	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HYDSHO_RS05460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYDSHO_RS05465	COG1733	regulation of RNA biosynthetic process
HYDSHO_RS05485	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HYDSHO_RS05495	COG3002	Belongs to the UPF0753 family
HYDSHO_RS05505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HYDSHO_RS05510	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HYDSHO_RS05520	COG0268	Binds directly to 16S ribosomal RNA
HYDSHO_RS05555	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HYDSHO_RS05560	COG0805	protein transport
HYDSHO_RS05565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYDSHO_RS05570	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HYDSHO_RS05575	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYDSHO_RS05580	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HYDSHO_RS05605	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HYDSHO_RS05610	COG0215	cysteine-tRNA ligase activity
HYDSHO_RS05620	COG0575	Belongs to the CDS family
HYDSHO_RS05625	COG0772	Belongs to the SEDS family
HYDSHO_RS05635	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HYDSHO_RS05640	COG1561	YicC-like family, N-terminal region
HYDSHO_RS05665	COG0438	transferase activity, transferring glycosyl groups
HYDSHO_RS05675	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HYDSHO_RS05680	COG3189	MarR family transcriptional regulator
HYDSHO_RS05705	COG0681	Belongs to the peptidase S26 family
HYDSHO_RS05710	COG0303	'Molybdopterin
HYDSHO_RS05720	COG2022	thiamine diphosphate biosynthetic process
HYDSHO_RS05725	COG1231	oxidoreductase activity
HYDSHO_RS05750	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYDSHO_RS05755	COG0799	negative regulation of ribosome biogenesis
HYDSHO_RS05770	COG1193	negative regulation of DNA recombination
HYDSHO_RS05775	COG0668	transmembrane transport
HYDSHO_RS05780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYDSHO_RS05800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HYDSHO_RS05805	COG1388	LysM domain
HYDSHO_RS05805	COG0791	NLP P60 protein
HYDSHO_RS05815	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HYDSHO_RS05825	COG4654	Cytochrome c, class I
HYDSHO_RS05830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYDSHO_RS05835	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HYDSHO_RS05845	COG0247	lactate metabolic process
HYDSHO_RS05850	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HYDSHO_RS05860	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HYDSHO_RS05865	COG3706	GGDEF domain
HYDSHO_RS05875	COG0352	thiamine-phosphate diphosphorylase activity
HYDSHO_RS05890	COG1203	CRISPR-associated helicase, Cas3
HYDSHO_RS05900	COG1518	maintenance of DNA repeat elements
HYDSHO_RS05905	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HYDSHO_RS05920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYDSHO_RS05935	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HYDSHO_RS05950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYDSHO_RS05955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HYDSHO_RS05960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYDSHO_RS05965	COG4752	Belongs to the RNA methyltransferase TrmD family
HYDSHO_RS05970	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HYDSHO_RS05980	COG0151	Belongs to the GarS family
HYDSHO_RS05990	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HYDSHO_RS06000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYDSHO_RS06010	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HYDSHO_RS06015	COG0616	signal peptide processing
HYDSHO_RS06020	COG0134	indole-3-glycerol-phosphate synthase activity
HYDSHO_RS06030	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HYDSHO_RS06035	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HYDSHO_RS06040	COG0440	acetolactate synthase activity
HYDSHO_RS06050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYDSHO_RS06055	COG0006	proline dipeptidase activity
HYDSHO_RS06060	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HYDSHO_RS06065	COG0067	glutamate synthase
HYDSHO_RS06065	COG0069	glutamate synthase activity
HYDSHO_RS06065	COG0070	glutamate synthase
HYDSHO_RS06090	COG0525	valine-tRNA ligase activity
HYDSHO_RS06105	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
HYDSHO_RS06110	COG0726	polysaccharide deacetylase
HYDSHO_RS06115	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYDSHO_RS06125	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HYDSHO_RS06135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HYDSHO_RS06140	COG1547	Domain of unknown function (DUF309)
HYDSHO_RS06145	COG0667	Aldo Keto reductase
HYDSHO_RS06150	COG1459	type II secretion system
HYDSHO_RS06155	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HYDSHO_RS06165	COG0181	hydroxymethylbilane synthase activity
HYDSHO_RS06175	COG0084	hydrolase, TatD family'
HYDSHO_RS06180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYDSHO_RS06195	COG0142	geranyltranstransferase activity
HYDSHO_RS06200	COG0167	dihydroorotate dehydrogenase activity
HYDSHO_RS06205	COG2361	Protein of unknown function DUF86
HYDSHO_RS06215	COG0322	excinuclease ABC activity
HYDSHO_RS06225	COG0745	RESPONSE REGULATOR receiver
HYDSHO_RS06230	COG0159	tryptophan synthase activity
HYDSHO_RS06235	COG0233	cytoplasmic translational termination
HYDSHO_RS06240	COG1923	regulation of RNA biosynthetic process
HYDSHO_RS06255	COG0148	phosphopyruvate hydratase activity
HYDSHO_RS06270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYDSHO_RS06275	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HYDSHO_RS06280	COG0135	phosphoribosylanthranilate isomerase activity
HYDSHO_RS06285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HYDSHO_RS06290	COG0473	3-isopropylmalate dehydrogenase activity
HYDSHO_RS06300	COG3118	belongs to the thioredoxin family
HYDSHO_RS06305	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HYDSHO_RS06310	COG2911	Protein conserved in bacteria
HYDSHO_RS06315	COG2076	Multidrug Resistance protein
HYDSHO_RS06335	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HYDSHO_RS06340	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HYDSHO_RS06345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYDSHO_RS06350	COG0196	riboflavin kinase activity
HYDSHO_RS06355	COG0528	UMP kinase activity
HYDSHO_RS06360	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HYDSHO_RS06365	COG0052	Belongs to the universal ribosomal protein uS2 family
HYDSHO_RS06390	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HYDSHO_RS06395	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HYDSHO_RS06400	COG0363	glucosamine-6-phosphate deaminase activity
HYDSHO_RS06425	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HYDSHO_RS06435	COG0720	synthase
HYDSHO_RS06470	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HYDSHO_RS06475	COG1396	sequence-specific DNA binding
HYDSHO_RS06495	COG3260	NADH ubiquinone oxidoreductase 20
HYDSHO_RS06500	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYDSHO_RS06500	COG0649	NAD binding
HYDSHO_RS06505	COG0651	ATP synthesis coupled electron transport
HYDSHO_RS06515	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HYDSHO_RS06520	COG0651	ATP synthesis coupled electron transport
HYDSHO_RS06525	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HYDSHO_RS06525	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYDSHO_RS06530	COG1216	Glycosyl transferase, family 2
HYDSHO_RS06530	COG0463	Glycosyl transferase, family 2
HYDSHO_RS06535	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HYDSHO_RS06540	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HYDSHO_RS06580	COG0778	Nitroreductase
HYDSHO_RS06615	COG0644	oxidoreductase
HYDSHO_RS06635	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HYDSHO_RS06645	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HYDSHO_RS06645	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HYDSHO_RS06650	COG2389	metal-binding protein
HYDSHO_RS06690	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYDSHO_RS06690	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYDSHO_RS06700	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HYDSHO_RS06705	COG0489	protein tyrosine kinase activity
HYDSHO_RS06710	COG1104	cysteine desulfurase activity
HYDSHO_RS06715	COG0583	DNA-binding transcription factor activity
HYDSHO_RS06720	COG0546	phosphoglycolate phosphatase activity
HYDSHO_RS06725	COG0484	heat shock protein binding
HYDSHO_RS06735	COG1127	ABC transporter
HYDSHO_RS06755	COG2894	cell division
HYDSHO_RS06760	COG0850	regulation of cytokinetic process
HYDSHO_RS06765	COG2226	methyltransferase
HYDSHO_RS06770	COG0149	triose-phosphate isomerase activity
HYDSHO_RS06780	COG0312	modulator of DNA gyrase
HYDSHO_RS06790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HYDSHO_RS06800	COG0509	glycine decarboxylation via glycine cleavage system
HYDSHO_RS06815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HYDSHO_RS06825	COG0546	phosphoglycolate phosphatase activity
HYDSHO_RS06835	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HYDSHO_RS06840	COG0658	competence protein
HYDSHO_RS06845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYDSHO_RS06850	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HYDSHO_RS06855	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYDSHO_RS06865	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HYDSHO_RS06875	COG1872	DUF167
HYDSHO_RS06885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HYDSHO_RS06900	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HYDSHO_RS06910	COG0463	Glycosyl transferase, family 2
HYDSHO_RS06925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYDSHO_RS06940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HYDSHO_RS06945	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HYDSHO_RS06955	COG3411	Ferredoxin
HYDSHO_RS06965	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HYDSHO_RS06970	COG0864	Transcriptional regulator
HYDSHO_RS06980	COG0443	Heat shock 70 kDa protein
HYDSHO_RS07000	COG5001	Diguanylate cyclase
HYDSHO_RS07005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HYDSHO_RS07010	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HYDSHO_RS07020	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HYDSHO_RS07020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYDSHO_RS07025	COG3706	GGDEF domain
HYDSHO_RS07030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYDSHO_RS07045	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HYDSHO_RS07050	COG1702	phosphate starvation-inducible protein PhoH
HYDSHO_RS07055	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HYDSHO_RS07065	COG1242	4 iron, 4 sulfur cluster binding
HYDSHO_RS07100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HYDSHO_RS07140	COG5398	heme oxygenase
HYDSHO_RS07145	COG0538	isocitrate dehydrogenase activity
HYDSHO_RS07155	COG0439	Biotin carboxylase
HYDSHO_RS07160	COG5016	pyruvate
HYDSHO_RS07160	COG0511	ligase activity, forming carbon-carbon bonds
HYDSHO_RS07165	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYDSHO_RS07165	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYDSHO_RS07170	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYDSHO_RS07185	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HYDSHO_RS07185	COG1796	DNA polymerase
HYDSHO_RS07190	COG0517	IMP dehydrogenase activity
HYDSHO_RS07190	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HYDSHO_RS07190	COG0617	tRNA 3'-terminal CCA addition
HYDSHO_RS07205	COG1902	pentaerythritol trinitrate reductase activity
HYDSHO_RS07225	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HYDSHO_RS07230	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYDSHO_RS07235	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HYDSHO_RS07245	COG2703	oxygen carrier activity
HYDSHO_RS07250	COG0492	ferredoxin-NADP+ reductase activity
HYDSHO_RS07255	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HYDSHO_RS07260	COG0154	amidase activity
HYDSHO_RS07270	COG0210	DNA helicase
HYDSHO_RS07275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HYDSHO_RS07280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYDSHO_RS07295	COG2814	Major facilitator Superfamily
HYDSHO_RS07305	COG0438	transferase activity, transferring glycosyl groups
HYDSHO_RS07315	COG1692	metallophosphoesterase
HYDSHO_RS07330	COG0546	phosphoglycolate phosphatase activity
HYDSHO_RS07330	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HYDSHO_RS07340	COG0512	Glutamine amidotransferase of anthranilate synthase
HYDSHO_RS07350	COG1131	(ABC) transporter
HYDSHO_RS07370	COG0437	4 iron, 4 sulfur cluster binding
HYDSHO_RS07375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYDSHO_RS07380	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HYDSHO_RS07390	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYDSHO_RS07395	COG1419	protein localization to endoplasmic reticulum
HYDSHO_RS07405	COG1573	uracil-dna glycosylase
HYDSHO_RS07410	COG1881	PFAM PEBP family protein
HYDSHO_RS07415	COG0542	response to heat
HYDSHO_RS07430	COG1333	cytochrome c biogenesis protein
HYDSHO_RS07440	COG0242	peptide deformylase activity
HYDSHO_RS07445	COG0785	Cytochrome C biogenesis protein
HYDSHO_RS07450	COG0728	peptidoglycan biosynthetic process
HYDSHO_RS07455	COG1515	deoxyribonuclease V activity
HYDSHO_RS07460	COG2078	PFAM AMMECR1 domain protein
HYDSHO_RS07470	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HYDSHO_RS07475	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HYDSHO_RS07485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HYDSHO_RS07490	COG0163	prenyltransferase activity
HYDSHO_RS07495	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HYDSHO_RS07510	COG0003	Pfam Anion-transporting ATPase
HYDSHO_RS07515	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HYDSHO_RS07520	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HYDSHO_RS07525	COG0235	Class ii aldolase
HYDSHO_RS07535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HYDSHO_RS07550	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYDSHO_RS07555	COG0564	pseudouridine synthase activity
HYDSHO_RS07565	COG0588	phosphoglycerate mutase activity
HYDSHO_RS07570	COG0425	Belongs to the sulfur carrier protein TusA family
HYDSHO_RS07580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HYDSHO_RS07585	COG0633	Ferredoxin
HYDSHO_RS07590	COG0501	Belongs to the peptidase M48B family
HYDSHO_RS07600	COG0358	DNA primase activity
HYDSHO_RS07615	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HYDSHO_RS07625	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYDSHO_RS07655	COG2217	Heavy metal translocating P-type atpase
HYDSHO_RS07660	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HYDSHO_RS07665	COG0352	thiamine-phosphate diphosphorylase activity
HYDSHO_RS07675	COG4786	Flagellar basal body rod
HYDSHO_RS07680	COG0504	CTP synthase activity
HYDSHO_RS07695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYDSHO_RS07700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYDSHO_RS07705	COG0314	molybdopterin synthase activity
HYDSHO_RS07710	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HYDSHO_RS07715	COG0037	tRNA processing
HYDSHO_RS07720	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HYDSHO_RS07735	COG0543	2 iron, 2 sulfur cluster binding
HYDSHO_RS07785	COG0275	rRNA processing
HYDSHO_RS07795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HYDSHO_RS07805	COG0463	Glycosyl transferase, family 2
HYDSHO_RS07835	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HYDSHO_RS07865	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HYDSHO_RS07875	COG1450	Type ii and iii secretion system protein
HYDSHO_RS07900	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HYDSHO_RS07900	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HYDSHO_RS07915	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HYDSHO_RS07920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYDSHO_RS07920	COG0574	Belongs to the PEP-utilizing enzyme family
HYDSHO_RS07930	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HYDSHO_RS07935	COG1830	Aldolase
HYDSHO_RS07940	COG0751	glycine-tRNA ligase activity
HYDSHO_RS07945	COG0752	glycyl-tRNA synthetase alpha subunit
HYDSHO_RS07950	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HYDSHO_RS07960	COG0285	dihydrofolate synthase activity
HYDSHO_RS07965	COG0617	tRNA 3'-terminal CCA addition
HYDSHO_RS07970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYDSHO_RS07975	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HYDSHO_RS07995	COG1324	tolerance protein
HYDSHO_RS08005	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HYDSHO_RS08010	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HYDSHO_RS08050	COG0587	DNA-directed DNA polymerase activity
HYDSHO_RS08060	COG0573	inorganic phosphate transmembrane transporter activity
HYDSHO_RS08065	COG0581	inorganic phosphate transmembrane transporter activity
HYDSHO_RS08070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HYDSHO_RS08075	COG0406	alpha-ribazole phosphatase activity
HYDSHO_RS08090	COG0287	Prephenate dehydrogenase
HYDSHO_RS08100	COG0187	DNA topoisomerase II activity
HYDSHO_RS08105	COG2217	Heavy metal translocating P-type atpase
HYDSHO_RS08115	COG2200	EAL domain
HYDSHO_RS08120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HYDSHO_RS08125	COG0779	Required for maturation of 30S ribosomal subunits
HYDSHO_RS08130	COG0195	Participates in both transcription termination and antitermination
HYDSHO_RS08135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HYDSHO_RS08140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYDSHO_RS08175	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYDSHO_RS08190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYDSHO_RS08195	COG0792	nuclease activity
HYDSHO_RS08200	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HYDSHO_RS08215	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation