locus-tag	class	description
E5678_RS00020	COG2233	PERMEase
E5678_RS00025	COG0281	malic enzyme
E5678_RS00025	COG0280	phosphate acetyltransferase
E5678_RS00030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5678_RS00045	COG2186	Transcriptional regulator
E5678_RS00075	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E5678_RS00080	COG1022	Amp-dependent synthetase and ligase
E5678_RS00120	COG2885	chlorophyll binding
E5678_RS00160	COG2226	methyltransferase
E5678_RS00220	COG0583	DNA-binding transcription factor activity
E5678_RS00255	COG1573	uracil-dna glycosylase
E5678_RS00260	COG2814	Major facilitator Superfamily
E5678_RS00265	COG0842	Transport permease protein
E5678_RS00270	COG1131	(ABC) transporter
E5678_RS00280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5678_RS00290	COG0596	Alpha beta hydrolase
E5678_RS00290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5678_RS00290	COG2226	methyltransferase
E5678_RS00300	COG1295	ribonuclease BN
E5678_RS00315	COG0351	phosphomethylpyrimidine kinase
E5678_RS00320	COG2022	thiamine diphosphate biosynthetic process
E5678_RS00325	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
E5678_RS00340	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E5678_RS00345	COG2205	protein histidine kinase activity
E5678_RS00385	COG3046	protein related to deoxyribodipyrimidine photolyase
E5678_RS00430	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5678_RS00445	COG3845	ABC transporter
E5678_RS00450	COG4603	Belongs to the binding-protein-dependent transport system permease family
E5678_RS00470	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5678_RS00485	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E5678_RS00490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5678_RS00490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E5678_RS00495	COG1056	cytidyltransferase-related domain
E5678_RS00495	COG1051	belongs to the nudix hydrolase family
E5678_RS00530	COG0587	DNA-directed DNA polymerase activity
E5678_RS00550	COG2814	Major facilitator Superfamily
E5678_RS00605	COG1858	cytochrome C peroxidase
E5678_RS00655	COG4771	TonB-dependent receptor
E5678_RS00670	COG0745	RESPONSE REGULATOR receiver
E5678_RS00685	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E5678_RS00705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E5678_RS00710	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E5678_RS00725	COG2840	Smr protein MutS2
E5678_RS00730	COG2003	Belongs to the UPF0758 family
E5678_RS00735	COG1047	Peptidyl-prolyl cis-trans
E5678_RS00740	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E5678_RS00745	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E5678_RS00755	COG0784	Response regulator, receiver
E5678_RS00755	COG2205	protein histidine kinase activity
E5678_RS00760	COG2197	response regulator
E5678_RS00765	COG0180	Tryptophanyl-tRNA synthetase
E5678_RS00770	COG1994	Peptidase M50
E5678_RS00775	COG0009	L-threonylcarbamoyladenylate synthase
E5678_RS00780	COG0697	spore germination
E5678_RS00785	COG0613	PHP domain protein
E5678_RS00790	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E5678_RS00795	COG0181	hydroxymethylbilane synthase activity
E5678_RS00815	COG1530	ribonuclease E activity
E5678_RS00820	COG0564	pseudouridine synthase activity
E5678_RS00840	COG0616	signal peptide processing
E5678_RS00840	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E5678_RS00845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E5678_RS00850	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E5678_RS00855	COG0424	maF-like protein
E5678_RS00860	COG1399	metal-binding, possibly nucleic acid-binding protein
E5678_RS00865	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E5678_RS00870	COG0416	fatty acid biosynthetic process
E5678_RS00875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5678_RS00880	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E5678_RS00890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5678_RS00895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5678_RS00920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5678_RS00930	COG0681	Belongs to the peptidase S26 family
E5678_RS00940	COG0571	ribonuclease III activity
E5678_RS00945	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E5678_RS00950	COG1381	Involved in DNA repair and RecF pathway recombination
E5678_RS00955	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E5678_RS00960	COG0736	holo-[acyl-carrier-protein] synthase activity
E5678_RS00965	COG1472	Belongs to the glycosyl hydrolase 3 family
E5678_RS00975	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E5678_RS00980	COG0159	tryptophan synthase activity
E5678_RS00985	COG0133	tryptophan synthase activity
E5678_RS00990	COG0135	phosphoribosylanthranilate isomerase activity
E5678_RS00995	COG0101	tRNA pseudouridine synthase activity
E5678_RS01005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E5678_RS01010	COG0473	3-isopropylmalate dehydrogenase activity
E5678_RS01015	COG0066	3-isopropylmalate dehydratase activity
E5678_RS01020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5678_RS01025	COG0583	DNA-binding transcription factor activity
E5678_RS01030	COG0372	Belongs to the citrate synthase family
E5678_RS01035	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E5678_RS01040	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E5678_RS01045	COG1053	succinate dehydrogenase
E5678_RS01060	COG2188	Transcriptional regulator
E5678_RS01065	COG0039	L-malate dehydrogenase activity
E5678_RS01075	COG1049	propionate catabolic process, 2-methylcitrate cycle
E5678_RS01090	COG0840	transmembrane signaling receptor activity
E5678_RS01095	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E5678_RS01100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5678_RS01105	COG0714	Associated with various cellular activities
E5678_RS01120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5678_RS01135	COG3483	tryptophan 2,3-dioxygenase activity
E5678_RS01155	COG0784	Response regulator, receiver
E5678_RS01155	COG4191	Histidine kinase
E5678_RS01160	COG0727	PFAM Uncharacterised protein family (UPF0153)
E5678_RS01175	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E5678_RS01180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5678_RS01200	COG0268	Binds directly to 16S ribosomal RNA
E5678_RS01205	COG0728	peptidoglycan biosynthetic process
E5678_RS01210	COG2912	Transglutaminase-like superfamily
E5678_RS01220	COG4977	sequence-specific DNA binding
E5678_RS01220	COG1917	Cupin 2, conserved barrel domain protein
E5678_RS01240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E5678_RS01245	COG0628	permease
E5678_RS01250	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5678_RS01260	COG0617	tRNA 3'-terminal CCA addition
E5678_RS01285	COG0259	pyridoxamine-phosphate oxidase activity
E5678_RS01315	COG2205	protein histidine kinase activity
E5678_RS01315	COG0784	Response regulator, receiver
E5678_RS01315	COG2198	Histidine kinase
E5678_RS01320	COG0443	Heat shock 70 kDa protein
E5678_RS01330	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS01400	COG0625	glutathione transferase activity
E5678_RS01405	COG1902	pentaerythritol trinitrate reductase activity
E5678_RS01440	COG0673	inositol 2-dehydrogenase activity
E5678_RS01490	COG1607	acyl-coa hydrolase
E5678_RS01500	COG2358	TRAP transporter, solute receptor (TAXI family
E5678_RS01515	COG2358	TRAP transporter, solute receptor (TAXI family
E5678_RS01520	COG4974	Belongs to the 'phage' integrase family
E5678_RS01535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5678_RS01540	COG3148	PFAM DTW domain containing protein
E5678_RS01545	COG0513	Belongs to the DEAD box helicase family
E5678_RS01555	COG2833	Protein of unknown function (DUF455)
E5678_RS01570	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E5678_RS01590	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E5678_RS01595	COG0148	phosphopyruvate hydratase activity
E5678_RS01605	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E5678_RS01610	COG0504	CTP synthase activity
E5678_RS01620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5678_RS01625	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E5678_RS01645	COG2005	Transcriptional regulator
E5678_RS01645	COG3585	molybdate ion transport
E5678_RS01650	COG1131	(ABC) transporter
E5678_RS01675	COG0535	radical SAM domain protein
E5678_RS01690	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E5678_RS01710	COG3608	succinylglutamate desuccinylase aspartoacylase
E5678_RS01710	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E5678_RS01725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E5678_RS01755	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5678_RS01760	COG2974	May be involved in recombination
E5678_RS01765	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E5678_RS01785	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E5678_RS01790	COG0287	Prephenate dehydrogenase
E5678_RS01800	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E5678_RS01815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E5678_RS01820	COG0546	phosphoglycolate phosphatase activity
E5678_RS01835	COG1187	pseudouridine synthase activity
E5678_RS01860	COG0174	glutamine synthetase
E5678_RS01870	COG3852	Histidine kinase
E5678_RS01930	COG2003	Belongs to the UPF0758 family
E5678_RS01980	COG0582	viral genome integration into host DNA
E5678_RS01985	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E5678_RS01995	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E5678_RS02015	COG0277	FAD linked oxidase domain protein
E5678_RS02025	COG1295	ribonuclease BN
E5678_RS02035	COG2124	cytochrome p450
E5678_RS02040	COG0438	transferase activity, transferring glycosyl groups
E5678_RS02085	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E5678_RS02090	COG2814	Major facilitator Superfamily
E5678_RS02120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5678_RS02130	COG1335	isochorismatase
E5678_RS02140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5678_RS02150	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E5678_RS02155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5678_RS02170	COG1403	HNH endonuclease
E5678_RS02195	COG1760	l-serine dehydratase
E5678_RS02205	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5678_RS02205	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5678_RS02215	COG0509	glycine decarboxylation via glycine cleavage system
E5678_RS02220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E5678_RS02225	COG1072	(Pantothenic acid kinase))
E5678_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS02255	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5678_RS02275	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5678_RS02310	COG1012	belongs to the aldehyde dehydrogenase family
E5678_RS02320	COG4176	ABC-type proline glycine betaine transport system permease component
E5678_RS02335	COG1012	belongs to the aldehyde dehydrogenase family
E5678_RS02360	COG1176	ABC-type spermidine putrescine transport system, permease component I
E5678_RS02370	COG3842	ATPase activity
E5678_RS02380	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E5678_RS02385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5678_RS02390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E5678_RS02400	COG0564	pseudouridine synthase activity
E5678_RS02405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E5678_RS02420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5678_RS02430	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
E5678_RS02435	COG0583	DNA-binding transcription factor activity
E5678_RS02440	COG1741	Belongs to the pirin family
E5678_RS02450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5678_RS02450	COG0475	glutathione-regulated potassium exporter activity
E5678_RS02460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5678_RS02505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5678_RS02530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5678_RS02545	COG1131	(ABC) transporter
E5678_RS02560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5678_RS02640	COG0659	secondary active sulfate transmembrane transporter activity
E5678_RS02655	COG0848	biopolymer transport protein
E5678_RS02665	COG0824	Thioesterase
E5678_RS02675	COG0436	Aminotransferase
E5678_RS02680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5678_RS02685	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E5678_RS02700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5678_RS02700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5678_RS02730	COG4969	Belongs to the N-Me-Phe pilin family
E5678_RS02735	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5678_RS02740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5678_RS02745	COG0741	lytic transglycosylase activity
E5678_RS02755	COG3228	Belongs to the MtfA family
E5678_RS02760	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5678_RS02765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E5678_RS02770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E5678_RS02785	COG0215	cysteine-tRNA ligase activity
E5678_RS02795	COG0825	malonyl-CoA metabolic process
E5678_RS02800	COG0037	tRNA processing
E5678_RS02840	COG0642	Histidine kinase
E5678_RS02850	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E5678_RS02870	COG0411	ABC transporter
E5678_RS02900	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E5678_RS02905	COG1011	Hydrolase
E5678_RS02910	COG0431	NADPH-dependent FMN reductase
E5678_RS02915	COG0625	glutathione transferase activity
E5678_RS02925	COG4176	ABC-type proline glycine betaine transport system permease component
E5678_RS02930	COG4175	Glycine betaine
E5678_RS02930	COG3448	diguanylate cyclase activity
E5678_RS02940	COG1067	ATP-dependent peptidase activity
E5678_RS02945	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
E5678_RS02975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5678_RS02985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E5678_RS02990	COG2358	TRAP transporter, solute receptor (TAXI family
E5678_RS03010	COG0544	peptidyl-prolyl cis-trans isomerase activity
E5678_RS03015	COG0740	serine-type endopeptidase activity
E5678_RS03020	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E5678_RS03025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E5678_RS03060	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E5678_RS03075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5678_RS03080	COG4654	Cytochrome c, class I
E5678_RS03090	COG0129	dihydroxy-acid dehydratase activity
E5678_RS03095	COG0129	dihydroxy-acid dehydratase activity
E5678_RS03100	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E5678_RS03115	COG2217	Heavy metal translocating P-type atpase
E5678_RS03125	COG3278	Belongs to the heme-copper respiratory oxidase family
E5678_RS03160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5678_RS03165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5678_RS03175	COG0697	spore germination
E5678_RS03180	COG2224	Isocitrate lyase
E5678_RS03190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E5678_RS03195	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E5678_RS03200	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E5678_RS03205	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E5678_RS03210	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E5678_RS03215	COG0072	phenylalanine-tRNA ligase activity
E5678_RS03215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5678_RS03220	COG0776	regulation of translation
E5678_RS03295	COG1538	Outer membrane efflux protein
E5678_RS03375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5678_RS03400	COG0277	FAD linked oxidase domain protein
E5678_RS03405	COG5383	Protein conserved in bacteria
E5678_RS03410	COG0154	amidase activity
E5678_RS03435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5678_RS03445	COG2186	Transcriptional regulator
E5678_RS03470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5678_RS03480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5678_RS03515	COG4680	protein conserved in bacteria
E5678_RS03530	COG2003	Belongs to the UPF0758 family
E5678_RS03575	COG0513	Belongs to the DEAD box helicase family
E5678_RS03580	COG0023	Translation Initiation Factor
E5678_RS03590	COG0560	Phosphoserine phosphatase
E5678_RS03595	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E5678_RS03600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E5678_RS03600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E5678_RS03605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E5678_RS03630	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS03640	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5678_RS03655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5678_RS03665	COG0557	exoribonuclease II activity
E5678_RS03670	COG0762	integral membrane protein
E5678_RS03675	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E5678_RS03675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E5678_RS03680	COG1652	LysM domain
E5678_RS03685	COG0052	Belongs to the universal ribosomal protein uS2 family
E5678_RS03690	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E5678_RS03695	COG0528	UMP kinase activity
E5678_RS03715	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E5678_RS03720	COG0750	zinc metalloprotease
E5678_RS03735	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5678_RS03740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5678_RS03745	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5678_RS03750	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5678_RS03755	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5678_RS03760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5678_RS03765	COG0505	Belongs to the CarA family
E5678_RS03780	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E5678_RS03785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5678_RS03795	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E5678_RS03800	COG4566	intracellular signal transduction
E5678_RS03810	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E5678_RS03815	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5678_RS03820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5678_RS03825	COG2814	Major facilitator Superfamily
E5678_RS03850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5678_RS03865	COG0791	NLP P60 protein
E5678_RS03890	COG0567	Dehydrogenase, E1 component
E5678_RS03895	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5678_RS03900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5678_RS03905	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E5678_RS03910	COG0631	protein serine/threonine phosphatase activity
E5678_RS03915	COG1199	ATP-dependent helicase activity
E5678_RS03925	COG0564	pseudouridine synthase activity
E5678_RS03930	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E5678_RS03935	COG1187	pseudouridine synthase activity
E5678_RS03940	COG0105	UTP biosynthetic process
E5678_RS03945	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E5678_RS03960	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E5678_RS03965	COG0124	histidyl-tRNA synthetase
E5678_RS03975	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5678_RS03980	COG1160	GTP binding
E5678_RS03985	COG1923	regulation of RNA biosynthetic process
E5678_RS03990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5678_RS03995	COG0330	HflC and HflK could
E5678_RS04000	COG0330	HflC and HflK could
E5678_RS04005	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E5678_RS04010	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E5678_RS04015	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E5678_RS04020	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E5678_RS04025	COG0626	cystathionine gamma-synthase activity
E5678_RS04040	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E5678_RS04050	COG4181	ATPase activity
E5678_RS04055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5678_RS04060	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E5678_RS04075	COG2059	Chromate
E5678_RS04085	COG3279	Response regulator of the LytR AlgR family
E5678_RS04090	COG4251	negative regulation of phosphorylation
E5678_RS04095	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS04110	COG0183	Belongs to the thiolase family
E5678_RS04115	COG1960	acyl-CoA dehydrogenase activity
E5678_RS04120	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E5678_RS04135	COG1127	ABC transporter
E5678_RS04140	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E5678_RS04150	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E5678_RS04160	COG3267	Type II secretory pathway component ExeA
E5678_RS04160	COG3409	Peptidoglycan-binding domain 1 protein
E5678_RS04200	COG2304	oxidoreductase activity
E5678_RS04210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5678_RS04215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5678_RS04220	COG1414	Transcriptional regulator
E5678_RS04250	COG0411	ABC transporter
E5678_RS04280	COG0625	glutathione transferase activity
E5678_RS04305	COG1024	Enoyl-CoA hydratase
E5678_RS04310	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5678_RS04320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5678_RS04330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5678_RS04335	COG0252	asparaginase activity
E5678_RS04340	COG0563	adenylate kinase activity
E5678_RS04345	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E5678_RS04350	COG2835	tetraacyldisaccharide 4'-kinase activity
E5678_RS04355	COG1663	tetraacyldisaccharide 4'-kinase activity
E5678_RS04360	COG0848	biopolymer transport protein
E5678_RS04370	COG1570	exodeoxyribonuclease VII activity
E5678_RS04375	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E5678_RS04395	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E5678_RS04400	COG0542	response to heat
E5678_RS04410	COG0433	COG0433 Predicted ATPase
E5678_RS04415	COG0217	transcriptional regulatory protein
E5678_RS04420	COG0151	Belongs to the GarS family
E5678_RS04425	COG0408	coproporphyrinogen oxidase activity
E5678_RS04430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E5678_RS04435	COG0799	negative regulation of ribosome biogenesis
E5678_RS04440	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E5678_RS04445	COG0424	maF-like protein
E5678_RS04450	COG1530	ribonuclease E activity
E5678_RS04460	COG1132	(ABC) transporter
E5678_RS04465	COG0823	Involved in the tonB-independent uptake of proteins
E5678_RS04470	COG2885	chlorophyll binding
E5678_RS04480	COG2391	methyltransferase activity
E5678_RS04485	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E5678_RS04500	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E5678_RS04555	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E5678_RS04565	COG0028	Belongs to the TPP enzyme family
E5678_RS04570	COG0440	acetolactate synthase activity
E5678_RS04575	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E5678_RS04580	COG1183	phosphatidylcholine synthase activity
E5678_RS04585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5678_RS04590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5678_RS04600	COG1414	Transcriptional regulator
E5678_RS04605	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E5678_RS04610	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E5678_RS04645	COG4585	Histidine kinase
E5678_RS04650	COG2197	response regulator
E5678_RS04675	COG0517	IMP dehydrogenase activity
E5678_RS04720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E5678_RS04730	COG2217	Heavy metal translocating P-type atpase
E5678_RS04755	COG0406	alpha-ribazole phosphatase activity
E5678_RS04760	COG3588	fructose-bisphosphate aldolase
E5678_RS04770	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
E5678_RS04790	COG0330	HflC and HflK could
E5678_RS04810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5678_RS04825	COG2326	polyphosphate kinase activity
E5678_RS04835	COG2823	Periplasmic or secreted lipoprotein
E5678_RS04840	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS04850	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5678_RS04870	COG0356	it plays a direct role in the translocation of protons across the membrane
E5678_RS04880	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E5678_RS04885	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E5678_RS04890	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E5678_RS04915	COG2885	chlorophyll binding
E5678_RS04920	COG2885	chlorophyll binding
E5678_RS04940	COG3459	Glycosyltransferase 36 associated
E5678_RS05000	COG0492	ferredoxin-NADP+ reductase activity
E5678_RS05020	COG0175	sulfate reduction
E5678_RS05030	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5678_RS05035	COG0730	response to heat
E5678_RS05045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5678_RS05045	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E5678_RS05050	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E5678_RS05055	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E5678_RS05060	COG2326	polyphosphate kinase activity
E5678_RS05065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5678_RS05065	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E5678_RS05085	COG1643	Atp-dependent helicase
E5678_RS05095	COG0436	Aminotransferase
E5678_RS05100	COG0583	DNA-binding transcription factor activity
E5678_RS05120	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E5678_RS05145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E5678_RS05150	COG2235	arginine
E5678_RS05155	COG1288	antiporter activity
E5678_RS05170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E5678_RS05185	COG2826	transposase and inactivated derivatives, IS30 family
E5678_RS05190	COG2801	Transposase and inactivated derivatives
E5678_RS05195	COG2963	transposase activity
E5678_RS05220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5678_RS05250	COG2826	transposase and inactivated derivatives, IS30 family
E5678_RS05280	COG0582	viral genome integration into host DNA
E5678_RS05315	COG4166	transmembrane transport
E5678_RS05320	COG4174	ABC transporter (Permease)
E5678_RS05325	COG4239	(ABC) transporter, permease
E5678_RS05330	COG4172	Belongs to the ABC transporter superfamily
E5678_RS05345	COG0779	Required for maturation of 30S ribosomal subunits
E5678_RS05350	COG2251	uridine kinase activity
E5678_RS05350	COG0195	Participates in both transcription termination and antitermination
E5678_RS05355	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E5678_RS05360	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E5678_RS05365	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E5678_RS05370	COG1217	gtp-binding protein TYPA
E5678_RS05380	COG1024	Enoyl-CoA hydratase
E5678_RS05390	COG3736	Type IV secretory pathway, component VirB8
E5678_RS05400	COG2948	multi-organism process
E5678_RS05405	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
E5678_RS05425	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E5678_RS05430	COG2867	negative regulation of translational initiation
E5678_RS05435	COG2914	Belongs to the UPF0125 (RnfH) family
E5678_RS05450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5678_RS05450	COG0519	Catalyzes the synthesis of GMP from XMP
E5678_RS05460	COG2831	hemolysin activation secretion protein
E5678_RS05520	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E5678_RS05530	COG3852	Histidine kinase
E5678_RS05535	COG2204	response regulator
E5678_RS05545	COG2204	response regulator
E5678_RS05565	COG1619	proteins homologs of microcin C7 resistance protein MccF
E5678_RS05600	COG4160	amino acid transport
E5678_RS05625	COG3547	Transposase (IS116 IS110 IS902 family)
E5678_RS05640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5678_RS05690	COG0398	Pfam SNARE associated Golgi protein
E5678_RS05695	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5678_RS05785	COG2823	Periplasmic or secreted lipoprotein
E5678_RS05805	COG0084	hydrolase, TatD family'
E5678_RS05820	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E5678_RS05825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E5678_RS05875	COG2917	probably involved in intracellular septation
E5678_RS05885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5678_RS05890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E5678_RS05900	COG2267	carboxylic ester hydrolase activity
E5678_RS05930	COG0583	DNA-binding transcription factor activity
E5678_RS05935	COG2354	Protein conserved in bacteria
E5678_RS05945	COG0047	phosphoribosylformylglycinamidine synthase activity
E5678_RS05945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5678_RS05955	COG0024	Methionine aminopeptidase
E5678_RS05960	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E5678_RS05980	COG0242	peptide deformylase activity
E5678_RS06015	COG0596	Alpha beta hydrolase
E5678_RS06015	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5678_RS06035	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5678_RS06045	COG1196	nuclear chromosome segregation
E5678_RS06050	COG3300	MHYT domain
E5678_RS06050	COG5001	Diguanylate cyclase
E5678_RS06060	COG2171	N-acyltransferase activity
E5678_RS06070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5678_RS06075	COG2890	protein-(glutamine-N5) methyltransferase activity
E5678_RS06080	COG0488	(ABC) transporter
E5678_RS06100	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E5678_RS06105	COG0746	molybdenum cofactor guanylyltransferase activity
E5678_RS06110	COG0303	'Molybdopterin
E5678_RS06115	COG0328	RNA-DNA hybrid ribonuclease activity
E5678_RS06125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5678_RS06130	COG0741	lytic transglycosylase activity
E5678_RS06130	COG1388	LysM domain
E5678_RS06145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E5678_RS06150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E5678_RS06155	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E5678_RS06165	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
E5678_RS06170	COG1074	ATP-dependent DNA helicase activity
E5678_RS06185	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E5678_RS06190	COG0254	rRNA binding
E5678_RS06215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E5678_RS06220	COG0581	inorganic phosphate transmembrane transporter activity
E5678_RS06225	COG0573	inorganic phosphate transmembrane transporter activity
E5678_RS06230	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E5678_RS06240	COG0248	Ppx GppA phosphatase
E5678_RS06250	COG0784	Response regulator, receiver
E5678_RS06250	COG5002	protein histidine kinase activity
E5678_RS06265	COG0438	transferase activity, transferring glycosyl groups
E5678_RS06285	COG3876	Protein conserved in bacteria
E5678_RS06295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5678_RS06325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5678_RS06330	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E5678_RS06350	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E5678_RS06355	COG0167	dihydroorotate dehydrogenase activity
E5678_RS06360	COG0579	oxidoreductase
E5678_RS06370	COG0642	Histidine kinase
E5678_RS06375	COG0741	lytic transglycosylase activity
E5678_RS06375	COG1196	nuclear chromosome segregation
E5678_RS06375	COG0739	heme binding
E5678_RS06385	COG1459	type II secretion system
E5678_RS06445	COG4412	M6 family metalloprotease domain protein
E5678_RS06445	COG1404	Belongs to the peptidase S8 family
E5678_RS06475	COG0492	ferredoxin-NADP+ reductase activity
E5678_RS06485	COG3088	subunit of a heme lyase
E5678_RS06490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5678_RS06500	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E5678_RS06520	COG4133	protoheme IX ABC transporter activity
E5678_RS06555	COG0633	Ferredoxin
E5678_RS06560	COG0443	Heat shock 70 kDa protein
E5678_RS06565	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E5678_RS06575	COG0822	iron-sulfur transferase activity
E5678_RS06580	COG1104	cysteine desulfurase activity
E5678_RS06600	COG0556	nucleotide-excision repair
E5678_RS06615	COG2878	Part of a membrane complex involved in electron transport
E5678_RS06620	COG0840	transmembrane signaling receptor activity
E5678_RS06645	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E5678_RS06650	COG4770	biotin carboxylase activity
E5678_RS06655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5678_RS06660	COG1703	isobutyryl-CoA mutase activity
E5678_RS06665	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5678_RS06665	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5678_RS06670	COG1802	Transcriptional regulator
E5678_RS06680	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
E5678_RS06685	COG2815	serine threonine protein kinase
E5678_RS06685	COG0515	serine threonine protein kinase
E5678_RS06695	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5678_RS06700	COG0545	Peptidyl-prolyl cis-trans isomerase
E5678_RS06705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5678_RS06710	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS06715	COG0183	Belongs to the thiolase family
E5678_RS06720	COG3243	poly(R)-hydroxyalkanoic acid synthase
E5678_RS06740	COG1040	competence protein
E5678_RS06745	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E5678_RS06755	COG4638	Rieske (2fe-2S)
E5678_RS06820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5678_RS06830	COG1639	'signal transduction protein
E5678_RS06840	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E5678_RS06845	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS06850	COG2076	Multidrug Resistance protein
E5678_RS06855	COG1742	UPF0060 membrane protein
E5678_RS06865	COG2733	membrane
E5678_RS06875	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E5678_RS06880	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E5678_RS06885	COG1492	cobalamin metabolic process
E5678_RS06895	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E5678_RS06905	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E5678_RS06910	COG1120	ATPase activity
E5678_RS06915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5678_RS06920	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E5678_RS06935	COG1797	cobyrinic acid a,c-diamide synthase activity
E5678_RS06940	COG4206	TonB-dependent receptor
E5678_RS06960	COG0730	response to heat
E5678_RS06965	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5678_RS06990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5678_RS07000	COG0028	Belongs to the TPP enzyme family
E5678_RS07020	COG0542	response to heat
E5678_RS07025	COG2186	Transcriptional regulator
E5678_RS07030	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E5678_RS07050	COG0318	PFAM AMP-dependent synthetase and ligase
E5678_RS07055	COG0456	acetyltransferase
E5678_RS07055	COG0454	-acetyltransferase
E5678_RS07060	COG0314	molybdopterin synthase activity
E5678_RS07070	COG0303	'Molybdopterin
E5678_RS07075	COG1763	Mo-molybdopterin cofactor biosynthetic process
E5678_RS07090	COG0436	Aminotransferase
E5678_RS07100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E5678_RS07105	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E5678_RS07125	COG0359	binds to the 23S rRNA
E5678_RS07130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E5678_RS07140	COG0360	Binds together with S18 to 16S ribosomal RNA
E5678_RS07145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5678_RS07170	COG5002	protein histidine kinase activity
E5678_RS07170	COG2176	DNA-directed DNA polymerase activity
E5678_RS07175	COG0745	RESPONSE REGULATOR receiver
E5678_RS07180	COG5002	protein histidine kinase activity
E5678_RS07195	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E5678_RS07205	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5678_RS07225	COG3634	alkyl hydroperoxide reductase activity
E5678_RS07240	COG3128	pkhd-type hydroxylase
E5678_RS07270	COG3193	protein, possibly involved in utilization of glycolate and propanediol
E5678_RS07285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5678_RS07300	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E5678_RS07305	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E5678_RS07330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5678_RS07330	COG1017	nitric oxide dioxygenase activity
E5678_RS07340	COG0583	DNA-binding transcription factor activity
E5678_RS07345	COG2188	Transcriptional regulator
E5678_RS07355	COG0129	dihydroxy-acid dehydratase activity
E5678_RS07360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5678_RS07365	COG4598	ABC transporter
E5678_RS07370	COG0765	amino acid transport
E5678_RS07380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5678_RS07385	COG2986	histidine ammonia-lyase
E5678_RS07390	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E5678_RS07400	COG1228	amidohydrolase
E5678_RS07425	COG1921	L-seryl-tRNASec selenium transferase activity
E5678_RS07455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5678_RS07465	COG0776	regulation of translation
E5678_RS07480	COG0583	DNA-binding transcription factor activity
E5678_RS07490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5678_RS07500	COG0322	excinuclease ABC activity
E5678_RS07510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E5678_RS07520	COG1611	Belongs to the LOG family
E5678_RS07530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5678_RS07535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5678_RS07540	COG1309	transcriptional regulator
E5678_RS07545	COG1320	monovalent cation:proton antiporter activity
E5678_RS07550	COG2212	antiporter activity
E5678_RS07560	COG0651	ATP synthesis coupled electron transport
E5678_RS07565	COG1006	Multisubunit Na H antiporter MnhC subunit
E5678_RS07570	COG2111	Na H antiporter
E5678_RS07570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5678_RS07625	COG1024	Enoyl-CoA hydratase
E5678_RS07650	COG0741	lytic transglycosylase activity
E5678_RS07670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5678_RS07675	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E5678_RS07690	COG2850	peptidyl-arginine hydroxylation
E5678_RS07700	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E5678_RS07705	COG0756	dUTP diphosphatase activity
E5678_RS07710	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E5678_RS07720	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E5678_RS07725	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E5678_RS07735	COG1722	exodeoxyribonuclease VII activity
E5678_RS07755	COG2202	Pas domain
E5678_RS07755	COG2205	protein histidine kinase activity
E5678_RS07760	COG4251	negative regulation of phosphorylation
E5678_RS07770	COG0412	Dienelactone hydrolase
E5678_RS07790	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E5678_RS07825	COG0210	DNA helicase
E5678_RS07830	COG0516	GMP reductase activity
E5678_RS07840	COG2084	Dehydrogenase
E5678_RS07870	COG0318	PFAM AMP-dependent synthetase and ligase
E5678_RS07875	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E5678_RS07880	COG0745	RESPONSE REGULATOR receiver
E5678_RS07885	COG0802	atpase or kinase
E5678_RS07890	COG0860	N-Acetylmuramoyl-L-alanine amidase
E5678_RS07895	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E5678_RS07900	COG0842	Transport permease protein
E5678_RS07905	COG1131	(ABC) transporter
E5678_RS07925	COG2814	Major facilitator Superfamily
E5678_RS07930	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E5678_RS07935	COG1136	(ABC) transporter
E5678_RS07940	COG0837	glucose binding
E5678_RS07950	COG4154	Belongs to the RbsD FucU family
E5678_RS07960	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E5678_RS07965	COG0363	glucosamine-6-phosphate deaminase activity
E5678_RS07970	COG0129	dihydroxy-acid dehydratase activity
E5678_RS07975	COG0800	Aldolase
E5678_RS07980	COG0166	Belongs to the GPI family
E5678_RS07985	COG1803	Methylglyoxal synthase
E5678_RS07990	COG0583	DNA-binding transcription factor activity
E5678_RS08005	COG0583	DNA-binding transcription factor activity
E5678_RS08045	COG4452	Inner membrane protein CreD
E5678_RS08050	COG2205	protein histidine kinase activity
E5678_RS08055	COG0745	RESPONSE REGULATOR receiver
E5678_RS08085	COG1175	transmembrane transport
E5678_RS08090	COG3833	ABC-type maltose transport systems, permease component
E5678_RS08095	COG3842	ATPase activity
E5678_RS08105	COG0246	Mannitol dehydrogenase
E5678_RS08120	COG1070	Carbohydrate kinase
E5678_RS08125	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS08140	COG1960	acyl-CoA dehydrogenase activity
E5678_RS08170	COG3264	Mechanosensitive ion channel
E5678_RS08170	COG1196	nuclear chromosome segregation
E5678_RS08175	COG1024	Enoyl-CoA hydratase
E5678_RS08195	COG0123	including yeast histone deacetylase and acetoin utilization protein
E5678_RS08200	COG0714	Associated with various cellular activities
E5678_RS08215	COG2951	lytic endotransglycosylase activity
E5678_RS08230	COG2308	Evidence 4 Homologs of previously reported genes of
E5678_RS08245	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E5678_RS08255	COG2918	glutathione biosynthetic process
E5678_RS08260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5678_RS08270	COG2885	chlorophyll binding
E5678_RS08280	COG0564	pseudouridine synthase activity
E5678_RS08285	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS08295	COG0183	Belongs to the thiolase family
E5678_RS08320	COG0604	alcohol dehydrogenase
E5678_RS08330	COG0318	PFAM AMP-dependent synthetase and ligase
E5678_RS08335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5678_RS08340	COG4597	amino acid ABC transporter
E5678_RS08345	COG0765	amino acid transport
E5678_RS08350	COG1126	abc transporter atp-binding protein
E5678_RS08380	COG2132	Multicopper oxidase
E5678_RS08395	COG2205	protein histidine kinase activity
E5678_RS08420	COG0450	alkyl hydroperoxide reductase
E5678_RS08440	COG0488	(ABC) transporter
E5678_RS08455	COG0513	Belongs to the DEAD box helicase family
E5678_RS08490	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E5678_RS08495	COG3383	formate dehydrogenase (NAD+) activity
E5678_RS08505	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E5678_RS08510	COG2223	nitrite transmembrane transporter activity
E5678_RS08575	COG0123	including yeast histone deacetylase and acetoin utilization protein
E5678_RS08585	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5678_RS08590	COG1840	ABC-type Fe3 transport system, periplasmic component
E5678_RS08600	COG1595	DNA-templated transcription, initiation
E5678_RS08605	COG0745	RESPONSE REGULATOR receiver
E5678_RS08610	COG2205	protein histidine kinase activity
E5678_RS08620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5678_RS08625	COG0405	Gamma-glutamyltransferase
E5678_RS08630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5678_RS08635	COG0583	DNA-binding transcription factor activity
E5678_RS08640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5678_RS08645	COG0765	amino acid transport
E5678_RS08650	COG1126	abc transporter atp-binding protein
E5678_RS08655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5678_RS08660	COG0318	PFAM AMP-dependent synthetase and ligase
E5678_RS08670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E5678_RS08675	COG0318	PFAM AMP-dependent synthetase and ligase
E5678_RS08705	COG2133	pyrroloquinoline quinone binding
E5678_RS08715	COG2205	protein histidine kinase activity
E5678_RS08720	COG0745	RESPONSE REGULATOR receiver
E5678_RS08740	COG0667	Aldo Keto reductase
E5678_RS08775	COG2159	amidohydrolase
E5678_RS08785	COG0583	DNA-binding transcription factor activity
E5678_RS08790	COG0456	acetyltransferase
E5678_RS08795	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E5678_RS08800	COG1917	Cupin 2, conserved barrel domain protein
E5678_RS08805	COG5285	phytanoyl-CoA dioxygenase
E5678_RS08810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5678_RS08815	COG0765	amino acid transport
E5678_RS08820	COG0765	amino acid transport
E5678_RS08825	COG1126	abc transporter atp-binding protein
E5678_RS08850	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E5678_RS08855	COG1024	Enoyl-CoA hydratase
E5678_RS08865	COG0183	Belongs to the thiolase family
E5678_RS08890	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5678_RS08895	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E5678_RS08900	COG0443	Heat shock 70 kDa protein
E5678_RS08905	COG0484	heat shock protein binding
E5678_RS08915	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5678_RS08920	COG3279	Response regulator of the LytR AlgR family
E5678_RS08920	COG5000	phosphorelay sensor kinase activity
E5678_RS08955	COG3608	succinylglutamate desuccinylase aspartoacylase
E5678_RS08955	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E5678_RS08960	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E5678_RS08980	COG1136	(ABC) transporter
E5678_RS08990	COG1253	flavin adenine dinucleotide binding
E5678_RS08995	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E5678_RS09000	COG2951	lytic endotransglycosylase activity
E5678_RS09020	COG0393	Putative heavy-metal-binding
E5678_RS09025	COG3842	ATPase activity
E5678_RS09045	COG2814	Major facilitator Superfamily
E5678_RS09050	COG1566	PFAM secretion protein HlyD family protein
E5678_RS09055	COG1538	Outer membrane efflux protein
E5678_RS09080	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E5678_RS09100	COG1136	(ABC) transporter
E5678_RS09110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5678_RS09125	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS09150	COG2205	protein histidine kinase activity
E5678_RS09205	COG1132	(ABC) transporter
E5678_RS09225	COG4608	Belongs to the ABC transporter superfamily
E5678_RS09230	COG0444	Belongs to the ABC transporter superfamily
E5678_RS09235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5678_RS09240	COG0601	transmembrane transport
E5678_RS09245	COG0747	negative chemotaxis
E5678_RS09280	COG1007	ATP synthesis coupled electron transport
E5678_RS09295	COG0713	ATP synthesis coupled electron transport
E5678_RS09300	COG0839	Belongs to the complex I subunit 6 family
E5678_RS09305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5678_RS09310	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E5678_RS09315	COG1034	ATP synthesis coupled electron transport
E5678_RS09330	COG0649	NAD binding
E5678_RS09335	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5678_RS09340	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5678_RS09345	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5678_RS09360	COG0149	triose-phosphate isomerase activity
E5678_RS09365	COG3321	synthase
E5678_RS09365	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS09365	COG0604	alcohol dehydrogenase
E5678_RS09370	COG1185	polyribonucleotide nucleotidyltransferase activity
E5678_RS09375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E5678_RS09380	COG0436	Aminotransferase
E5678_RS09385	COG0683	leucine binding
E5678_RS09390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E5678_RS09410	COG0714	Associated with various cellular activities
E5678_RS09420	COG2010	Cytochrome c
E5678_RS09430	COG1845	cytochrome c oxidase, subunit III
E5678_RS09440	COG0535	radical SAM domain protein
E5678_RS09455	COG1522	sequence-specific DNA binding
E5678_RS09460	COG3391	amine dehydrogenase activity
E5678_RS09480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5678_RS09480	COG1648	precorrin-2 dehydrogenase activity
E5678_RS09485	COG3707	response regulator
E5678_RS09490	COG1116	anion transmembrane transporter activity
E5678_RS09490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5678_RS09495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5678_RS09500	COG1116	anion transmembrane transporter activity
E5678_RS09505	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5678_RS09515	COG0243	molybdopterin cofactor binding
E5678_RS09520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5678_RS09535	COG2081	HI0933 family
E5678_RS09550	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E5678_RS09555	COG0583	DNA-binding transcription factor activity
E5678_RS09570	COG1610	YqeY-like protein
E5678_RS09575	COG0312	modulator of DNA gyrase
E5678_RS09585	COG0521	Mo-molybdopterin cofactor biosynthetic process
E5678_RS09590	COG1047	Peptidyl-prolyl cis-trans
E5678_RS09595	COG1045	serine acetyltransferase
E5678_RS09605	COG0483	inositol monophosphate 1-phosphatase activity
E5678_RS09610	COG4251	negative regulation of phosphorylation
E5678_RS09625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E5678_RS09640	COG3447	MASE1 domain protein
E5678_RS09640	COG5001	Diguanylate cyclase
E5678_RS09640	COG5002	protein histidine kinase activity
E5678_RS09650	COG1968	undecaprenyl-diphosphatase activity
E5678_RS09675	COG3275	phosphorelay sensor kinase activity
E5678_RS09700	COG3550	peptidyl-serine autophosphorylation
E5678_RS09705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5678_RS09740	COG0210	DNA helicase
E5678_RS09755	COG0210	DNA helicase
E5678_RS09775	COG2010	Cytochrome c
E5678_RS09775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5678_RS09840	COG0835	chemotaxis
E5678_RS09840	COG0784	Response regulator, receiver
E5678_RS09855	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E5678_RS09900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5678_RS09920	COG0602	queuosine metabolic process
E5678_RS09925	COG0720	synthase
E5678_RS09970	COG1215	transferase activity, transferring glycosyl groups
E5678_RS09990	COG1088	dTDP-glucose 4,6-dehydratase activity
E5678_RS10000	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E5678_RS10040	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E5678_RS10060	COG0438	transferase activity, transferring glycosyl groups
E5678_RS10145	COG0463	Glycosyl transferase, family 2
E5678_RS10155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5678_RS10170	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E5678_RS10170	COG2755	lipolytic protein G-D-S-L family
E5678_RS10175	COG0513	Belongs to the DEAD box helicase family
E5678_RS10180	COG0306	phosphate transporter
E5678_RS10185	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E5678_RS10190	COG0501	Belongs to the peptidase M48B family
E5678_RS10195	COG2154	pterin-4-alpha-carbinolamine dehydratase
E5678_RS10200	COG1162	GTPase activity
E5678_RS10205	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E5678_RS10210	COG0494	nUDIX hydrolase
E5678_RS10215	COG0335	large ribosomal subunit rRNA binding
E5678_RS10225	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E5678_RS10230	COG0228	four-way junction DNA binding
E5678_RS10245	COG0679	Auxin Efflux Carrier
E5678_RS10265	COG3842	ATPase activity
E5678_RS10275	COG1121	(ABC) transporter
E5678_RS10285	COG0803	Belongs to the bacterial solute-binding protein 9 family
E5678_RS10310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5678_RS10315	COG0583	DNA-binding transcription factor activity
E5678_RS10320	COG1960	acyl-CoA dehydrogenase activity
E5678_RS10330	COG2814	Major facilitator Superfamily
E5678_RS10335	COG2824	Alkylphosphonate utilization operon protein PhnA
E5678_RS10345	COG3263	regulation of cellular component size
E5678_RS10350	COG1309	transcriptional regulator
E5678_RS10365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E5678_RS10370	COG1054	Belongs to the UPF0176 family
E5678_RS10385	COG1519	Transferase
E5678_RS10435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5678_RS10460	COG0285	dihydrofolate synthase activity
E5678_RS10470	COG1393	Belongs to the ArsC family
E5678_RS10475	COG3123	guanosine phosphorylase activity
E5678_RS10480	COG0137	argininosuccinate synthase activity
E5678_RS10495	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E5678_RS10500	COG1666	GTP binding
E5678_RS10510	COG0251	oxidation-reduction process
E5678_RS10515	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E5678_RS10520	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E5678_RS10525	COG0667	Aldo Keto reductase
E5678_RS10530	COG2885	chlorophyll binding
E5678_RS10535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5678_RS10560	COG0308	aminopeptidase N
E5678_RS10565	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E5678_RS10585	COG0582	viral genome integration into host DNA
E5678_RS10615	COG0737	Belongs to the 5'-nucleotidase family
E5678_RS10650	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E5678_RS10665	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5678_RS10690	COG4451	ribulose bisphosphate carboxylase, small
E5678_RS10695	COG1850	ribulose-bisphosphate carboxylase activity
E5678_RS10705	COG0191	fructose-bisphosphate aldolase activity
E5678_RS10715	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E5678_RS10720	COG3954	Phosphoribulokinase
E5678_RS10725	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E5678_RS10730	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E5678_RS10735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5678_RS10740	COG0583	DNA-binding transcription factor activity
E5678_RS10750	COG1054	Belongs to the UPF0176 family
E5678_RS10760	COG1639	'signal transduction protein
E5678_RS10770	COG2183	response to ionizing radiation
E5678_RS10780	COG2197	response regulator
E5678_RS10805	COG2814	Major facilitator Superfamily
E5678_RS10820	COG2153	protein acetylation
E5678_RS10830	COG1960	acyl-CoA dehydrogenase activity
E5678_RS10835	COG2130	NADP-dependent
E5678_RS10845	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS10855	COG1960	acyl-CoA dehydrogenase activity
E5678_RS10860	COG0183	Belongs to the thiolase family
E5678_RS10865	COG1024	Enoyl-CoA hydratase
E5678_RS10865	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5678_RS10875	COG0411	ABC transporter
E5678_RS10905	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5678_RS10910	COG2900	Belongs to the SlyX family
E5678_RS10915	COG0318	PFAM AMP-dependent synthetase and ligase
E5678_RS10935	COG1960	acyl-CoA dehydrogenase activity
E5678_RS10940	COG1024	Enoyl-CoA hydratase
E5678_RS10940	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5678_RS10945	COG0183	Belongs to the thiolase family
E5678_RS10950	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS10960	COG1960	acyl-CoA dehydrogenase activity
E5678_RS10965	COG0318	PFAM AMP-dependent synthetase and ligase
E5678_RS10995	COG0069	glutamate synthase activity
E5678_RS11005	COG0492	ferredoxin-NADP+ reductase activity
E5678_RS11010	COG0406	alpha-ribazole phosphatase activity
E5678_RS11035	COG0559	Belongs to the binding-protein-dependent transport system permease family
E5678_RS11090	COG2423	ornithine cyclodeaminase activity
E5678_RS11095	COG1253	flavin adenine dinucleotide binding
E5678_RS11100	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5678_RS11105	COG0513	Belongs to the DEAD box helicase family
E5678_RS11110	COG2321	neutral zinc metallopeptidase
E5678_RS11115	COG0717	Belongs to the dCTP deaminase family
E5678_RS11125	COG1271	oxidase subunit
E5678_RS11130	COG1294	oxidase, subunit
E5678_RS11135	COG0402	S-adenosylhomocysteine deaminase activity
E5678_RS11145	COG0489	protein tyrosine kinase activity
E5678_RS11150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5678_RS11150	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5678_RS11165	COG0659	secondary active sulfate transmembrane transporter activity
E5678_RS11180	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E5678_RS11185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5678_RS11205	COG1420	regulation of RNA biosynthetic process
E5678_RS11215	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E5678_RS11220	COG0497	DNA recombination
E5678_RS11225	COG1660	Displays ATPase and GTPase activities
E5678_RS11230	COG1194	a g-specific adenine glycosylase
E5678_RS11240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E5678_RS11265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E5678_RS11270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E5678_RS11275	COG0193	aminoacyl-tRNA hydrolase activity
E5678_RS11280	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5678_RS11285	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E5678_RS11290	COG0742	ribosomal rna small subunit methyltransferase
E5678_RS11295	COG0612	Peptidase, M16
E5678_RS11300	COG0612	Peptidase, M16
E5678_RS11315	COG1595	DNA-templated transcription, initiation
E5678_RS11330	COG3220	belongs to the UPF0276 family
E5678_RS11345	COG4134	Bacterial extracellular solute-binding protein
E5678_RS11350	COG4135	transport system, permease component
E5678_RS11355	COG4136	ATPase activity
E5678_RS11360	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5678_RS11395	COG0534	Mate efflux family protein
E5678_RS11400	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5678_RS11405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5678_RS11435	COG1846	Transcriptional regulator
E5678_RS11485	COG1335	isochorismatase
E5678_RS11555	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
E5678_RS11560	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E5678_RS11565	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E5678_RS11570	COG3639	organic phosphonate transmembrane transporter activity
E5678_RS11575	COG3639	organic phosphonate transmembrane transporter activity
E5678_RS11580	COG2076	Multidrug Resistance protein
E5678_RS11590	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E5678_RS11615	COG2133	pyrroloquinoline quinone binding
E5678_RS11700	COG0582	viral genome integration into host DNA
E5678_RS11715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5678_RS11720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E5678_RS11725	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E5678_RS11740	COG1561	YicC-like family, N-terminal region
E5678_RS11745	COG0194	GDP metabolic process
E5678_RS11750	COG1758	RNA polymerase activity
E5678_RS11760	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E5678_RS11770	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E5678_RS11775	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E5678_RS11785	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E5678_RS11790	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E5678_RS11795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E5678_RS11805	COG0588	phosphoglycerate mutase activity
E5678_RS11810	COG0793	Belongs to the peptidase S41A family
E5678_RS11815	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E5678_RS11825	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E5678_RS11845	COG0302	gtp cyclohydrolase
E5678_RS11850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5678_RS11890	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E5678_RS11905	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5678_RS11920	COG2226	methyltransferase
E5678_RS11935	COG1653	transport
E5678_RS11940	COG1175	transmembrane transport
E5678_RS11945	COG0395	ABC-type sugar transport system, permease component
E5678_RS11950	COG3842	ATPase activity
E5678_RS11955	COG0584	glycerophosphoryl diester phosphodiesterase
E5678_RS11965	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E5678_RS11970	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E5678_RS11975	COG2890	protein-(glutamine-N5) methyltransferase activity
E5678_RS11980	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E5678_RS11985	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E5678_RS11990	COG0741	lytic transglycosylase activity
E5678_RS11995	COG0442	prolyl-tRNA aminoacylation
E5678_RS12000	COG0494	nUDIX hydrolase
E5678_RS12005	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E5678_RS12010	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E5678_RS12015	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E5678_RS12020	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E5678_RS12025	COG0142	geranyltranstransferase activity
E5678_RS12040	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E5678_RS12045	COG0237	dephospho-CoA kinase activity
E5678_RS12050	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E5678_RS12055	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E5678_RS12070	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E5678_RS12075	COG0653	protein targeting
E5678_RS12080	COG0739	heme binding
E5678_RS12095	COG2969	positive regulation of protein catabolic process
E5678_RS12100	COG0625	glutathione transferase activity
E5678_RS12105	COG2857	Cytochrome c1
E5678_RS12110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E5678_RS12115	COG0723	plastoquinol--plastocyanin reductase activity
E5678_RS12120	COG1970	mechanosensitive ion channel activity
E5678_RS12130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E5678_RS12140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5678_RS12145	COG0805	protein transport
E5678_RS12150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5678_RS12155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5678_RS12160	COG0537	adenosine 5'-monophosphoramidase activity
E5678_RS12170	COG0140	phosphoribosyl-ATP diphosphatase activity
E5678_RS12175	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E5678_RS12185	COG0107	imidazoleglycerol-phosphate synthase activity
E5678_RS12195	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E5678_RS12205	COG0131	Imidazoleglycerol-phosphate dehydratase
E5678_RS12210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5678_RS12220	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E5678_RS12225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5678_RS12230	COG5007	Belongs to the BolA IbaG family
E5678_RS12235	COG0842	Transport permease protein
E5678_RS12240	COG1131	(ABC) transporter
E5678_RS12260	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E5678_RS12265	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E5678_RS12270	COG1127	ABC transporter
E5678_RS12280	COG0067	glutamate synthase
E5678_RS12280	COG0069	glutamate synthase activity
E5678_RS12280	COG0070	glutamate synthase
E5678_RS12295	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E5678_RS12300	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E5678_RS12305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E5678_RS12345	COG1965	Belongs to the frataxin family
E5678_RS12355	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E5678_RS12360	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E5678_RS12365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5678_RS12370	COG1333	cytochrome c biogenesis protein
E5678_RS12380	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E5678_RS12385	COG1560	Kdo2-lipid A biosynthetic process
E5678_RS12395	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E5678_RS12400	COG4251	negative regulation of phosphorylation
E5678_RS12405	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS12410	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E5678_RS12415	COG0459	protein refolding
E5678_RS12425	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5678_RS12435	COG4608	Belongs to the ABC transporter superfamily
E5678_RS12440	COG0444	Belongs to the ABC transporter superfamily
E5678_RS12445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5678_RS12450	COG4166	transmembrane transport
E5678_RS12455	COG1473	amidohydrolase
E5678_RS12480	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
E5678_RS12495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5678_RS12500	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E5678_RS12575	COG4178	(ABC) transporter
E5678_RS12580	COG2205	protein histidine kinase activity
E5678_RS12605	COG0431	NADPH-dependent FMN reductase
E5678_RS12615	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E5678_RS12625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E5678_RS12635	COG1705	Flagellar rod assembly protein muramidase FlgJ
E5678_RS12635	COG3951	Flagellar rod assembly protein muramidase FlgJ
E5678_RS12640	COG1706	bacterial-type flagellum-dependent cell motility
E5678_RS12645	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E5678_RS12660	COG1749	Flagellar hook protein flgE
E5678_RS12665	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E5678_RS12670	COG1558	bacterial-type flagellum-dependent cell motility
E5678_RS12675	COG1815	bacterial-type flagellum-dependent cell motility
E5678_RS12700	COG0473	3-isopropylmalate dehydrogenase activity
E5678_RS12700	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5678_RS12710	COG4122	O-methyltransferase activity
E5678_RS12720	COG1191	sigma factor activity
E5678_RS12745	COG0457	Tetratricopeptide repeat
E5678_RS12745	COG0463	Glycosyl transferase, family 2
E5678_RS12750	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E5678_RS12755	COG0745	RESPONSE REGULATOR receiver
E5678_RS12760	COG1360	Flagellar Motor Protein
E5678_RS12765	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E5678_RS12780	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E5678_RS12785	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E5678_RS12800	COG1677	Flagellar hook-basal body complex protein FliE
E5678_RS12805	COG1766	The M ring may be actively involved in energy transduction
E5678_RS12840	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E5678_RS12860	COG1987	bacterial-type flagellum assembly
E5678_RS12875	COG2197	response regulator
E5678_RS12890	COG0745	RESPONSE REGULATOR receiver
E5678_RS12895	COG0643	Histidine kinase
E5678_RS12895	COG2198	Histidine kinase
E5678_RS12900	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E5678_RS12905	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E5678_RS12910	COG2201	protein-glutamate methylesterase activity
E5678_RS12925	COG0784	Response regulator, receiver
E5678_RS12930	COG4251	negative regulation of phosphorylation
E5678_RS12935	COG0745	RESPONSE REGULATOR receiver
E5678_RS12940	COG2205	protein histidine kinase activity
E5678_RS12975	COG3181	Tripartite tricarboxylate transporter family receptor
E5678_RS12985	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5678_RS12990	COG0778	Nitroreductase
E5678_RS12995	COG1802	Transcriptional regulator
E5678_RS13010	COG1234	tRNA 3'-trailer cleavage
E5678_RS13045	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5678_RS13090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5678_RS13095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5678_RS13100	COG2205	protein histidine kinase activity
E5678_RS13105	COG0745	RESPONSE REGULATOR receiver
E5678_RS13110	COG1283	sodium-dependent phosphate transmembrane transporter activity
E5678_RS13160	COG0114	fumarate hydratase activity
E5678_RS13225	COG1174	glycine betaine transport
E5678_RS13230	COG1125	glycine betaine transport
E5678_RS13235	COG1174	glycine betaine transport
E5678_RS13240	COG1732	Glycine betaine
E5678_RS13255	COG1609	Transcriptional regulator
E5678_RS13300	COG0024	Methionine aminopeptidase
E5678_RS13305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E5678_RS13335	COG3609	addiction module antidote protein, CC2985 family
E5678_RS13345	COG2826	transposase and inactivated derivatives, IS30 family
E5678_RS13360	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E5678_RS13390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5678_RS13395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5678_RS13400	COG1902	pentaerythritol trinitrate reductase activity
E5678_RS13400	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5678_RS13555	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E5678_RS13585	COG1522	sequence-specific DNA binding
E5678_RS13595	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E5678_RS13625	COG0583	DNA-binding transcription factor activity
E5678_RS13640	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E5678_RS13645	COG0741	lytic transglycosylase activity
E5678_RS13645	COG0739	heme binding
E5678_RS13645	COG1196	nuclear chromosome segregation
E5678_RS13650	COG0702	epimerase
E5678_RS13655	COG1937	Protein conserved in bacteria
E5678_RS13665	COG0617	tRNA 3'-terminal CCA addition
E5678_RS13670	COG1877	trehalose-phosphatase activity
E5678_RS13675	COG3387	PFAM Glycoside hydrolase 15-related
E5678_RS13680	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E5678_RS13685	COG0668	transmembrane transport
E5678_RS13700	COG3842	ATPase activity
E5678_RS13705	COG0395	ABC-type sugar transport system, permease component
E5678_RS13750	COG0037	tRNA processing
E5678_RS13765	COG0406	alpha-ribazole phosphatase activity
E5678_RS13785	COG2255	four-way junction helicase activity
E5678_RS13790	COG3338	carbonate dehydratase activity
E5678_RS13805	COG0632	four-way junction helicase activity
E5678_RS13810	COG1702	phosphate starvation-inducible protein PhoH
E5678_RS13815	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E5678_RS13825	COG1490	D-aminoacyl-tRNA deacylase activity
E5678_RS13830	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E5678_RS13835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5678_RS13840	COG0739	heme binding
E5678_RS13845	COG0316	Belongs to the HesB IscA family
E5678_RS13860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E5678_RS13865	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E5678_RS13870	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E5678_RS13880	COG3396	Phenylacetate-CoA oxygenase
E5678_RS13885	COG3460	Phenylacetate-CoA oxygenase
E5678_RS13890	COG3396	Phenylacetate-CoA oxygenase
E5678_RS13895	COG2151	metal-sulfur cluster biosynthetic enzyme
E5678_RS13900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5678_RS13920	COG3047	cAMP biosynthetic process
E5678_RS13935	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E5678_RS13950	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E5678_RS13965	COG2391	methyltransferase activity
E5678_RS13990	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5678_RS13995	COG0683	leucine binding
E5678_RS14020	COG1280	lysine exporter protein (LysE YggA)
E5678_RS14035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5678_RS14050	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E5678_RS14055	COG2318	DinB family
E5678_RS14060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5678_RS14065	COG0318	PFAM AMP-dependent synthetase and ligase
E5678_RS14085	COG3038	cytochrome b561
E5678_RS14095	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E5678_RS14100	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E5678_RS14115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5678_RS14120	COG3012	SEC-C Motif Domain Protein
E5678_RS14135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5678_RS14145	COG1960	acyl-CoA dehydrogenase activity
E5678_RS14160	COG0183	Belongs to the thiolase family
E5678_RS14165	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E5678_RS14170	COG0288	reversible hydration of carbon dioxide
E5678_RS14175	COG1960	acyl-CoA dehydrogenase activity
E5678_RS14185	COG1739	Uncharacterized protein family UPF0029
E5678_RS14195	COG0789	Transcriptional regulator
E5678_RS14215	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E5678_RS14220	COG0751	glycine-tRNA ligase activity
E5678_RS14225	COG0752	glycyl-tRNA synthetase alpha subunit
E5678_RS14230	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E5678_RS14235	COG4535	Mg2 and Co2 transporter CorC
E5678_RS14245	COG1522	sequence-specific DNA binding
E5678_RS14255	COG3186	Phenylalanine-4-hydroxylase
E5678_RS14270	COG0318	PFAM AMP-dependent synthetase and ligase
E5678_RS14280	COG4689	acetoacetate decarboxylase
E5678_RS14285	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS14300	COG1595	DNA-templated transcription, initiation
E5678_RS14315	COG3220	belongs to the UPF0276 family
E5678_RS14335	COG0709	Synthesizes selenophosphate from selenide and ATP
E5678_RS14360	COG0318	PFAM AMP-dependent synthetase and ligase
E5678_RS14375	COG0203	ribosomal protein L17
E5678_RS14380	COG0202	RNA polymerase activity
E5678_RS14385	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E5678_RS14390	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E5678_RS14395	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E5678_RS14400	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E5678_RS14405	COG0201	protein transport
E5678_RS14410	COG0200	Binds to the 23S rRNA
E5678_RS14415	COG1841	ribosomal large subunit assembly
E5678_RS14420	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E5678_RS14425	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E5678_RS14430	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E5678_RS14435	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E5678_RS14440	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E5678_RS14445	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E5678_RS14450	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E5678_RS14455	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E5678_RS14460	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E5678_RS14475	COG0395	ABC-type sugar transport system, permease component
E5678_RS14485	COG3842	ATPase activity
E5678_RS14490	COG3842	ATPase activity
E5678_RS14500	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E5678_RS14510	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E5678_RS14515	COG0583	DNA-binding transcription factor activity
E5678_RS14520	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E5678_RS14525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5678_RS14530	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E5678_RS14535	COG0343	queuine tRNA-ribosyltransferase activity
E5678_RS14540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E5678_RS14555	COG1609	Transcriptional regulator
E5678_RS14560	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS14610	COG0583	DNA-binding transcription factor activity
E5678_RS14620	COG2226	methyltransferase
E5678_RS14625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5678_RS14635	COG0583	DNA-binding transcription factor activity
E5678_RS14655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5678_RS14675	COG0667	Aldo Keto reductase
E5678_RS14690	COG0473	3-isopropylmalate dehydrogenase activity
E5678_RS14695	COG0673	inositol 2-dehydrogenase activity
E5678_RS14700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E5678_RS14785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E5678_RS14800	COG0583	DNA-binding transcription factor activity
E5678_RS14805	COG0071	Belongs to the small heat shock protein (HSP20) family
E5678_RS14810	COG0277	FAD linked oxidase domain protein
E5678_RS14815	COG4251	negative regulation of phosphorylation
E5678_RS14830	COG0506	proline dehydrogenase activity
E5678_RS14830	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E5678_RS14830	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E5678_RS14860	COG2084	Dehydrogenase
E5678_RS14865	COG2823	Periplasmic or secreted lipoprotein
E5678_RS14870	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E5678_RS14875	COG0792	nuclease activity
E5678_RS14955	COG4251	negative regulation of phosphorylation
E5678_RS14975	COG1136	(ABC) transporter
E5678_RS14975	COG0577	efflux transmembrane transporter activity
E5678_RS14990	COG2423	ornithine cyclodeaminase activity
E5678_RS15000	COG2239	Acts as a magnesium transporter
E5678_RS15010	COG0471	metal ion transport
E5678_RS15010	COG3273	potassium ion transport
E5678_RS15035	COG2176	DNA-directed DNA polymerase activity
E5678_RS15050	COG1979	alcohol dehydrogenase
E5678_RS15055	COG1309	transcriptional regulator
E5678_RS15060	COG2962	Rard protein
E5678_RS15080	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E5678_RS15110	COG0095	Lipoate-protein ligase
E5678_RS15140	COG1450	Type ii and iii secretion system protein
E5678_RS15175	COG2885	chlorophyll binding
E5678_RS15215	COG3245	cytochrome
E5678_RS15235	COG1704	LemA family
E5678_RS15255	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E5678_RS15260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5678_RS15265	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E5678_RS15270	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E5678_RS15275	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E5678_RS15280	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E5678_RS15290	COG0356	it plays a direct role in the translocation of protons across the membrane
E5678_RS15305	COG2921	Belongs to the UPF0250 family
E5678_RS15310	COG0321	lipoyl(octanoyl) transferase activity
E5678_RS15315	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5678_RS15340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E5678_RS15345	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5678_RS15350	COG4232	protein-disulfide reductase activity
E5678_RS15355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5678_RS15370	COG1794	racemase activity, acting on amino acids and derivatives
E5678_RS15380	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E5678_RS15385	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E5678_RS15395	COG1309	transcriptional regulator
E5678_RS15400	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E5678_RS15405	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E5678_RS15420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5678_RS15490	COG0583	DNA-binding transcription factor activity
E5678_RS15505	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E5678_RS15535	COG2204	response regulator
E5678_RS15540	COG5000	phosphorelay sensor kinase activity
E5678_RS15550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5678_RS15550	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5678_RS15555	COG0501	Belongs to the peptidase M48B family
E5678_RS15560	COG1704	LemA family
E5678_RS15565	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E5678_RS15570	COG0085	RNA polymerase activity
E5678_RS15575	COG0222	ribosome binding
E5678_RS15580	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E5678_RS15585	COG0081	regulation of translation
E5678_RS15590	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E5678_RS15610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5678_RS15630	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E5678_RS15635	COG0134	indole-3-glycerol-phosphate synthase activity
E5678_RS15640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5678_RS15645	COG1280	lysine exporter protein (LysE YggA)
E5678_RS15655	COG0512	Glutamine amidotransferase of anthranilate synthase
E5678_RS15695	COG0546	phosphoglycolate phosphatase activity
E5678_RS15700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E5678_RS15705	COG2967	ApaG domain
E5678_RS15720	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E5678_RS15725	COG1546	Belongs to the CinA family
E5678_RS15745	COG4335	DNA alkylation repair
E5678_RS15755	COG3318	Belongs to the UPF0149 family
E5678_RS15755	COG3012	SEC-C Motif Domain Protein
E5678_RS15760	COG0069	glutamate synthase activity
E5678_RS15795	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E5678_RS15800	COG1137	ATPase activity
E5678_RS15820	COG0018	arginyl-trna synthetase
E5678_RS15845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5678_RS15865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5678_RS15880	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E5678_RS15890	COG0346	lactoylglutathione lyase activity
E5678_RS15895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5678_RS15900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5678_RS15920	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5678_RS15930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5678_RS15945	COG0456	acetyltransferase
E5678_RS15950	COG0678	peroxiredoxin activity
E5678_RS15955	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E5678_RS15960	COG0255	Belongs to the universal ribosomal protein uL29 family
E5678_RS15965	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E5678_RS15970	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E5678_RS15975	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E5678_RS15980	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E5678_RS15990	COG0089	rRNA binding
E5678_RS15995	COG0088	Forms part of the polypeptide exit tunnel
E5678_RS16000	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E5678_RS16005	COG0051	transcription antitermination factor activity, RNA binding
E5678_RS16010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5678_RS16015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E5678_RS16020	COG0049	tRNA binding
E5678_RS16025	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E5678_RS16030	COG1686	Belongs to the peptidase S11 family
E5678_RS16050	COG1981	membrane
E5678_RS16070	COG0598	Magnesium transport protein CorA
E5678_RS16075	COG0412	Dienelactone hydrolase
E5678_RS16085	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS16090	COG2030	dehydratase
E5678_RS16095	COG2095	MarC family integral membrane protein
E5678_RS16100	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E5678_RS16115	COG3971	2-oxopent-4-enoate hydratase activity
E5678_RS16125	COG3384	dioxygenase
E5678_RS16130	COG1012	belongs to the aldehyde dehydrogenase family
E5678_RS16135	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5678_RS16145	COG1846	Transcriptional regulator
E5678_RS16150	COG2070	2-Nitropropane dioxygenase
E5678_RS16195	COG2205	protein histidine kinase activity
E5678_RS16205	COG0318	PFAM AMP-dependent synthetase and ligase
E5678_RS16220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5678_RS16225	COG1522	sequence-specific DNA binding
E5678_RS16235	COG1522	sequence-specific DNA binding
E5678_RS16250	COG2202	Pas domain
E5678_RS16250	COG2205	protein histidine kinase activity
E5678_RS16280	COG3459	Glycosyltransferase 36 associated
E5678_RS16285	COG0708	Exodeoxyribonuclease III
E5678_RS16290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E5678_RS16300	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5678_RS16305	COG0154	amidase activity
E5678_RS16310	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5678_RS16315	COG1077	Cell shape determining protein MreB Mrl
E5678_RS16320	COG1792	Involved in formation and maintenance of cell shape
E5678_RS16330	COG0768	penicillin binding
E5678_RS16375	COG0004	ammonium transporteR
E5678_RS16405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E5678_RS16440	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS16445	COG0583	DNA-binding transcription factor activity
E5678_RS16460	COG0670	Belongs to the BI1 family
E5678_RS16475	COG1937	Protein conserved in bacteria
E5678_RS16505	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5678_RS16510	COG0477	Major facilitator Superfamily
E5678_RS16520	COG0386	Belongs to the glutathione peroxidase family
E5678_RS16530	COG1380	Effector of murein hydrolase LrgA
E5678_RS16535	COG0247	lactate metabolic process
E5678_RS16540	COG0277	FAD linked oxidase domain protein
E5678_RS16550	COG0004	ammonium transporteR
E5678_RS16570	COG0646	methionine synthase
E5678_RS16570	COG1410	methionine synthase
E5678_RS16580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5678_RS16600	COG0411	ABC transporter
E5678_RS16625	COG0745	RESPONSE REGULATOR receiver
E5678_RS16630	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E5678_RS16640	COG1741	Belongs to the pirin family
E5678_RS16650	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E5678_RS16655	COG0861	Integral membrane protein TerC family
E5678_RS16670	COG2897	thiosulfate sulfurtransferase activity
E5678_RS16695	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5678_RS16695	COG1902	pentaerythritol trinitrate reductase activity
E5678_RS16720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5678_RS16720	COG0519	Catalyzes the synthesis of GMP from XMP
E5678_RS16730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5678_RS16735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5678_RS16755	COG0668	transmembrane transport
E5678_RS16765	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E5678_RS16800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5678_RS16805	COG2866	Carboxypeptidase
E5678_RS16810	COG1960	acyl-CoA dehydrogenase activity
E5678_RS16815	COG2267	carboxylic ester hydrolase activity
E5678_RS16825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5678_RS16850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5678_RS16860	COG1136	(ABC) transporter
E5678_RS16875	COG2233	PERMEase
E5678_RS16880	COG2818	Glycosylase
E5678_RS16885	COG2050	protein possibly involved in aromatic compounds catabolism
E5678_RS16890	COG0693	protein deglycase activity
E5678_RS16900	COG1360	Flagellar Motor Protein
E5678_RS16905	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5678_RS16915	COG2096	Adenosyltransferase
E5678_RS16925	COG2096	Adenosyltransferase
E5678_RS16935	COG0277	FAD linked oxidase domain protein
E5678_RS16950	COG0702	epimerase
E5678_RS16955	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS16960	COG1309	transcriptional regulator
E5678_RS16965	COG1475	DNA binding
E5678_RS16975	COG1192	Involved in chromosome partitioning
E5678_RS16985	COG0357	Ribosomal RNA small subunit methyltransferase G
E5678_RS16990	COG0445	tRNA wobble uridine modification
E5678_RS17030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E5678_RS17035	COG1012	belongs to the aldehyde dehydrogenase family
E5678_RS17040	COG1177	transmembrane transport
E5678_RS17045	COG1176	ABC-type spermidine putrescine transport system, permease component I
E5678_RS17050	COG3842	ATPase activity
E5678_RS17065	COG0174	glutamine synthetase
E5678_RS17070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E5678_RS17090	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E5678_RS17100	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E5678_RS17105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5678_RS17110	COG0010	Belongs to the arginase family
E5678_RS17115	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E5678_RS17165	COG2217	Heavy metal translocating P-type atpase
E5678_RS17175	COG0789	Transcriptional regulator
E5678_RS17200	COG0123	including yeast histone deacetylase and acetoin utilization protein
E5678_RS17205	COG0045	succinate-CoA ligase (ADP-forming) activity
E5678_RS17205	COG1042	CoA-binding domain protein
E5678_RS17205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5678_RS17215	COG0850	regulation of cytokinetic process
E5678_RS17220	COG2894	cell division
E5678_RS17225	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E5678_RS17235	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5678_RS17255	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E5678_RS17265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5678_RS17290	COG0791	NLP P60 protein
E5678_RS17305	COG2186	Transcriptional regulator
E5678_RS17310	COG2084	Dehydrogenase
E5678_RS17315	COG3395	kinase activity
E5678_RS17320	COG0235	Class ii aldolase
E5678_RS17325	COG3622	Belongs to the hyi family
E5678_RS17330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5678_RS17335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E5678_RS17340	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E5678_RS17350	COG1012	belongs to the aldehyde dehydrogenase family
E5678_RS17360	COG0318	PFAM AMP-dependent synthetase and ligase
E5678_RS17365	COG0778	Nitroreductase
E5678_RS17380	COG3220	belongs to the UPF0276 family
E5678_RS17395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5678_RS17405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5678_RS17425	COG1254	Belongs to the acylphosphatase family
E5678_RS17435	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS17465	COG3727	T/G mismatch-specific endonuclease activity
E5678_RS17485	COG0203	ribosomal protein L17
E5678_RS17590	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5678_RS17605	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E5678_RS17610	COG0594	ribonuclease P activity
E5678_RS17615	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E5678_RS17620	COG0706	membrane insertase activity
E5678_RS17625	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E5678_RS17640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5678_RS17655	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E5678_RS17665	COG4221	oxidoreductase activity
E5678_RS17680	COG0724	RNA recognition motif
E5678_RS17685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5678_RS17690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5678_RS17690	COG2813	Specifically methylates the guanine in position
E5678_RS17700	COG0840	transmembrane signaling receptor activity
E5678_RS17705	COG0835	chemotaxis
E5678_RS17710	COG0840	transmembrane signaling receptor activity
E5678_RS17715	COG0840	transmembrane signaling receptor activity
E5678_RS17720	COG0835	chemotaxis
E5678_RS17725	COG0840	transmembrane signaling receptor activity
E5678_RS17735	COG0840	transmembrane signaling receptor activity
E5678_RS17740	COG0840	transmembrane signaling receptor activity
E5678_RS17745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5678_RS17750	COG2267	carboxylic ester hydrolase activity
E5678_RS17760	COG2814	Major facilitator Superfamily
E5678_RS17765	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5678_RS17770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5678_RS17775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5678_RS17785	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E5678_RS17790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5678_RS17795	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5678_RS17810	COG0280	phosphate acetyltransferase
E5678_RS17810	COG0281	malic enzyme
E5678_RS17855	COG1196	nuclear chromosome segregation
E5678_RS17855	COG3264	Mechanosensitive ion channel
E5678_RS17870	COG2258	MOSC domain
E5678_RS17875	COG0006	proline dipeptidase activity
E5678_RS17895	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E5678_RS17900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E5678_RS17910	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E5678_RS17910	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E5678_RS17935	COG0625	glutathione transferase activity
E5678_RS17965	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E5678_RS17975	COG2137	regulation of response to DNA damage stimulus
E5678_RS17980	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E5678_RS17985	COG0045	succinate-CoA ligase (ADP-forming) activity
E5678_RS17990	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E5678_RS17995	COG0515	serine threonine protein kinase
E5678_RS17995	COG2815	serine threonine protein kinase
E5678_RS18000	COG0631	protein serine/threonine phosphatase activity
E5678_RS18005	COG1716	ATPase activity
E5678_RS18015	COG1234	tRNA 3'-trailer cleavage
E5678_RS18020	COG4969	Belongs to the N-Me-Phe pilin family
E5678_RS18025	COG4969	Belongs to the N-Me-Phe pilin family
E5678_RS18030	COG4969	Belongs to the N-Me-Phe pilin family
E5678_RS18035	COG4969	Belongs to the N-Me-Phe pilin family
E5678_RS18045	COG0315	cyclic pyranopterin monophosphate synthase activity
E5678_RS18055	COG1950	PFAM Membrane protein of
E5678_RS18060	COG0861	Integral membrane protein TerC family
E5678_RS18080	COG0625	glutathione transferase activity
E5678_RS18090	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E5678_RS18100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5678_RS18105	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E5678_RS18135	COG0489	protein tyrosine kinase activity
E5678_RS18155	COG1051	belongs to the nudix hydrolase family
E5678_RS18180	COG0438	transferase activity, transferring glycosyl groups
E5678_RS18200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5678_RS18205	COG0662	Cupin 2, conserved barrel domain protein
E5678_RS18205	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E5678_RS18250	COG1522	sequence-specific DNA binding
E5678_RS18260	COG1862	Preprotein translocase
E5678_RS18265	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5678_RS18270	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5678_RS18280	COG0758	DNA mediated transformation
E5678_RS18290	COG0242	peptide deformylase activity
E5678_RS18300	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E5678_RS18315	COG0463	Glycosyl transferase, family 2
E5678_RS18325	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E5678_RS18345	COG0642	Histidine kinase
E5678_RS18350	COG2194	sulfuric ester hydrolase activity
E5678_RS18400	COG0126	phosphoglycerate kinase activity
E5678_RS18410	COG0671	phosphoesterase, PA-phosphatase related
E5678_RS18415	COG2832	Protein of unknown function (DUF454)
E5678_RS18425	COG1902	pentaerythritol trinitrate reductase activity
E5678_RS18430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5678_RS18435	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E5678_RS18460	COG2205	protein histidine kinase activity
E5678_RS18465	COG2197	response regulator
E5678_RS18475	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E5678_RS18480	COG0163	prenyltransferase activity
E5678_RS18490	COG3154	lipid carrier protein
E5678_RS18495	COG1272	protein, Hemolysin III
E5678_RS18500	COG0826	peptidase U32
E5678_RS18505	COG0826	peptidase U32
E5678_RS18515	COG1959	2 iron, 2 sulfur cluster binding
E5678_RS18525	COG3850	Histidine kinase
E5678_RS18530	COG2197	response regulator
E5678_RS18545	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E5678_RS18550	COG1140	nitrate reductase beta subunit
E5678_RS18555	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E5678_RS18560	COG2181	nitrate reductase activity
E5678_RS18565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5678_RS18570	COG0288	reversible hydration of carbon dioxide
E5678_RS18610	COG3781	membrane
E5678_RS18625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5678_RS18645	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E5678_RS18655	COG0174	glutamine synthetase
E5678_RS18660	COG0625	glutathione transferase activity
E5678_RS18695	COG0628	permease
E5678_RS18710	COG2201	protein-glutamate methylesterase activity
E5678_RS18715	COG4585	Histidine kinase
E5678_RS18725	COG3237	CsbD-like
E5678_RS18735	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E5678_RS18740	COG0583	DNA-binding transcription factor activity
E5678_RS18765	COG0439	Biotin carboxylase
E5678_RS18770	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E5678_RS18775	COG1984	allophanate hydrolase subunit 2
E5678_RS18795	COG0800	Aldolase
E5678_RS18800	COG3734	2-keto-3-deoxy-galactonokinase
E5678_RS18815	COG4716	Myosin-crossreactive antigen
E5678_RS18820	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E5678_RS18830	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E5678_RS18845	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5678_RS18860	COG0473	3-isopropylmalate dehydrogenase activity
E5678_RS18895	COG0473	3-isopropylmalate dehydrogenase activity
E5678_RS18900	COG2824	Alkylphosphonate utilization operon protein PhnA
E5678_RS18905	COG0659	secondary active sulfate transmembrane transporter activity
E5678_RS18910	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E5678_RS18935	COG0469	pyruvate kinase activity
E5678_RS18955	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E5678_RS18975	COG0840	transmembrane signaling receptor activity
E5678_RS18980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5678_RS18985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5678_RS18995	COG0667	Aldo Keto reductase
E5678_RS19000	COG3118	belongs to the thioredoxin family
E5678_RS19005	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E5678_RS19010	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E5678_RS19015	COG0009	L-threonylcarbamoyladenylate synthase
E5678_RS19030	COG2027	D-alanyl-D-alanine carboxypeptidase
E5678_RS19035	COG1214	PFAM Peptidase M22, glycoprotease
E5678_RS19040	COG0456	acetyltransferase
E5678_RS19050	COG0697	spore germination
E5678_RS19060	COG0284	orotidine-5'-phosphate decarboxylase activity
E5678_RS19065	COG0625	glutathione transferase activity
E5678_RS19095	COG2814	Major facilitator Superfamily
E5678_RS19125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5678_RS19140	COG2346	COG2346, Truncated hemoglobins
E5678_RS19155	COG2226	methyltransferase
E5678_RS19170	COG0450	alkyl hydroperoxide reductase
E5678_RS19175	COG0482	sulfurtransferase activity
E5678_RS19180	COG3384	dioxygenase
E5678_RS19185	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E5678_RS19190	COG3842	ATPase activity
E5678_RS19195	COG1176	ABC-type spermidine putrescine transport system, permease component I
E5678_RS19200	COG1177	transmembrane transport
E5678_RS19205	COG4303	Ethanolamine ammonia lyase large subunit
E5678_RS19230	COG0494	nUDIX hydrolase
E5678_RS19235	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E5678_RS19240	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E5678_RS19245	COG0318	PFAM AMP-dependent synthetase and ligase
E5678_RS19250	COG1522	sequence-specific DNA binding
E5678_RS19265	COG0598	Magnesium transport protein CorA
E5678_RS19280	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E5678_RS19290	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E5678_RS19295	COG0735	belongs to the Fur family
E5678_RS19300	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5678_RS19305	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E5678_RS19325	COG0495	leucyl-tRNA aminoacylation
E5678_RS19340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5678_RS19350	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E5678_RS19360	COG3158	transport of potassium into the cell
E5678_RS19370	COG0189	ligase activity
E5678_RS19375	COG4628	conserved protein (DUF2132)
E5678_RS19390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5678_RS19405	COG0121	glutamine amidotransferase
E5678_RS19410	COG2814	Major facilitator Superfamily
E5678_RS19415	COG1115	amino acid carrier protein
E5678_RS19435	COG2010	Cytochrome c
E5678_RS19435	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5678_RS19470	COG0384	phenazine biosynthesis protein PhzF
E5678_RS19475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5678_RS19480	COG1280	lysine exporter protein (LysE YggA)
E5678_RS19495	COG0436	Aminotransferase
E5678_RS19500	COG0488	(ABC) transporter
E5678_RS19575	COG0251	oxidation-reduction process
E5678_RS19585	COG1960	acyl-CoA dehydrogenase activity
E5678_RS19590	COG1024	Enoyl-CoA hydratase
E5678_RS19620	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E5678_RS19640	COG4566	intracellular signal transduction
E5678_RS19665	COG0559	Belongs to the binding-protein-dependent transport system permease family
E5678_RS19675	COG1022	Amp-dependent synthetase and ligase
E5678_RS19685	COG1187	pseudouridine synthase activity
E5678_RS19700	COG0326	Molecular chaperone. Has ATPase activity
E5678_RS19730	COG1764	response to oxidative stress
E5678_RS19735	COG1846	Transcriptional regulator
E5678_RS19740	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E5678_RS19745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5678_RS19770	COG0842	Transport permease protein
E5678_RS19775	COG1131	(ABC) transporter
E5678_RS19780	COG0688	phosphatidylethanolamine metabolic process
E5678_RS19785	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E5678_RS19790	COG3647	Membrane
E5678_RS19795	COG0577	efflux transmembrane transporter activity
E5678_RS19795	COG1136	(ABC) transporter
E5678_RS19800	COG0577	efflux transmembrane transporter activity
E5678_RS19800	COG1136	(ABC) transporter
E5678_RS19815	COG0668	transmembrane transport
E5678_RS19820	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E5678_RS19850	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5678_RS19860	COG2329	Antibiotic biosynthesis monooxygenase
E5678_RS19865	COG1280	lysine exporter protein (LysE YggA)
E5678_RS19870	COG0010	Belongs to the arginase family
E5678_RS19895	COG1137	ATPase activity
E5678_RS19900	COG5001	Diguanylate cyclase
E5678_RS19905	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5678_RS19905	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5678_RS19905	COG1703	isobutyryl-CoA mutase activity
E5678_RS19910	COG2326	polyphosphate kinase activity
E5678_RS19915	COG1937	Protein conserved in bacteria
E5678_RS19920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5678_RS19925	COG0156	8-amino-7-oxononanoate synthase activity
E5678_RS19945	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E5678_RS19970	COG0243	molybdopterin cofactor binding
E5678_RS19980	COG1473	amidohydrolase
E5678_RS20010	COG4221	oxidoreductase activity
E5678_RS20015	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5678_RS20030	COG1960	acyl-CoA dehydrogenase activity
E5678_RS20040	COG1024	Enoyl-CoA hydratase
E5678_RS20040	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5678_RS20050	COG0183	Belongs to the thiolase family
E5678_RS20060	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5678_RS20065	COG1024	Enoyl-CoA hydratase
E5678_RS20075	COG3795	YCII-related domain
E5678_RS20080	COG5507	3-demethylubiquinone-9 3-methyltransferase
E5678_RS20105	COG4941	Belongs to the sigma-70 factor family
E5678_RS20115	COG0259	pyridoxamine-phosphate oxidase activity
E5678_RS20120	COG1063	alcohol dehydrogenase
E5678_RS20125	COG1301	dicarboxylic acid transport
E5678_RS20140	COG1609	Transcriptional regulator
E5678_RS20145	COG0765	amino acid transport
E5678_RS20150	COG0765	amino acid transport
E5678_RS20155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5678_RS20160	COG1126	abc transporter atp-binding protein
E5678_RS20170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5678_RS20180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E5678_RS20185	COG0517	IMP dehydrogenase activity
E5678_RS20195	COG0217	transcriptional regulatory protein
E5678_RS20200	COG0557	exoribonuclease II activity
E5678_RS20220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E5678_RS20230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E5678_RS20240	COG0356	it plays a direct role in the translocation of protons across the membrane
E5678_RS20260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5678_RS20275	COG3268	Saccharopine dehydrogenase
E5678_RS20280	COG2205	protein histidine kinase activity
E5678_RS20305	COG1607	acyl-coa hydrolase
E5678_RS20310	COG5265	(ABC) transporter
E5678_RS20325	COG0418	dihydroorotase activity
E5678_RS20335	COG0501	Belongs to the peptidase M48B family
E5678_RS20345	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
E5678_RS20355	COG0534	Mate efflux family protein
E5678_RS20375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5678_RS20380	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E5678_RS20390	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E5678_RS20400	COG0523	cobalamin synthesis protein
E5678_RS20415	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E5678_RS20420	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E5678_RS20425	COG2001	Belongs to the MraZ family
E5678_RS20430	COG0275	rRNA processing
E5678_RS20445	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5678_RS20450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E5678_RS20455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E5678_RS20460	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E5678_RS20465	COG0772	Belongs to the SEDS family
E5678_RS20470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E5678_RS20475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5678_RS20480	COG1181	Belongs to the D-alanine--D-alanine ligase family
E5678_RS20485	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E5678_RS20495	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E5678_RS20500	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E5678_RS20510	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E5678_RS20515	COG4589	Belongs to the CDS family
E5678_RS20535	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
E5678_RS20545	COG0772	Belongs to the SEDS family
E5678_RS20550	COG2084	Dehydrogenase
E5678_RS20555	COG0312	modulator of DNA gyrase
E5678_RS20560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5678_RS20575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5678_RS20585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5678_RS20590	COG0511	ligase activity, forming carbon-carbon bonds
E5678_RS20595	COG0439	Biotin carboxylase
E5678_RS20600	COG2264	protein methyltransferase activity
E5678_RS20655	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E5678_RS20665	COG1414	Transcriptional regulator
E5678_RS20670	COG0300	oxidoreductase activity
E5678_RS20675	COG2072	flavoprotein involved in K transport
E5678_RS20680	COG0385	Bile acid
E5678_RS20685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5678_RS20690	COG0697	spore germination
E5678_RS20705	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
E5678_RS20710	COG2204	response regulator
E5678_RS20720	COG2205	protein histidine kinase activity
E5678_RS20725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5678_RS20750	COG1024	Enoyl-CoA hydratase
E5678_RS20755	COG1024	Enoyl-CoA hydratase
E5678_RS20760	COG2050	protein possibly involved in aromatic compounds catabolism
E5678_RS20780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5678_RS20785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5678_RS20795	COG0012	GTP binding
E5678_RS20805	COG2814	Major facilitator Superfamily
E5678_RS20810	COG1238	metal cluster binding
E5678_RS20815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5678_RS20820	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E5678_RS20825	COG0138	bifunctional purine biosynthesis protein purh
E5678_RS20830	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E5678_RS20840	COG1773	rubredoxin
E5678_RS20860	COG0840	transmembrane signaling receptor activity
E5678_RS20870	COG0415	Belongs to the DNA photolyase family
E5678_RS20875	COG1678	Uncharacterized ACR, COG1678
E5678_RS20880	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E5678_RS20885	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E5678_RS20890	COG0540	Belongs to the ATCase OTCase family
E5678_RS20895	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E5678_RS20920	COG0625	glutathione transferase activity
E5678_RS20930	COG1999	signal sequence binding
E5678_RS20935	COG2847	Copper chaperone PCu(A)C
E5678_RS20955	COG3842	ATPase activity
E5678_RS20960	COG1178	ABC-type Fe3 transport system permease component
E5678_RS20970	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E5678_RS20980	COG2119	membrane
E5678_RS20985	COG2911	Protein conserved in bacteria
E5678_RS21000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5678_RS21015	COG0183	Belongs to the thiolase family
E5678_RS21050	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E5678_RS21055	COG1040	competence protein
E5678_RS21060	COG2226	methyltransferase
E5678_RS21075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5678_RS21080	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E5678_RS21115	COG0109	protoheme IX farnesyltransferase activity
E5678_RS21120	COG1999	signal sequence binding
E5678_RS21130	COG0642	Histidine kinase
E5678_RS21135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5678_RS21175	COG2816	NAD+ diphosphatase activity
E5678_RS21180	COG0425	Belongs to the sulfur carrier protein TusA family
E5678_RS21190	COG0525	valine-tRNA ligase activity
E5678_RS21205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5678_RS21215	COG1592	Rubrerythrin
E5678_RS21220	COG0247	lactate metabolic process
E5678_RS21240	COG3022	response to hydroperoxide
E5678_RS21255	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E5678_RS21255	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E5678_RS21265	COG1595	DNA-templated transcription, initiation
E5678_RS21310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5678_RS21325	COG1304	FMN binding
E5678_RS21335	COG4585	Histidine kinase
E5678_RS21365	COG3237	CsbD-like
E5678_RS21370	COG2197	response regulator
E5678_RS21375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5678_RS21385	COG1295	ribonuclease BN
E5678_RS21415	COG0628	permease
E5678_RS21435	COG1309	transcriptional regulator
E5678_RS21445	COG0471	metal ion transport
E5678_RS21495	COG0583	DNA-binding transcription factor activity
E5678_RS21510	COG3932	Exopolysaccharide synthesis, ExoD
E5678_RS21515	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5678_RS21525	COG0004	ammonium transporteR
E5678_RS21540	COG3152	Membrane
E5678_RS21555	COG0165	Argininosuccinate lyase
E5678_RS21560	COG3275	phosphorelay sensor kinase activity
E5678_RS21590	COG4591	ABC-type transport system involved in lipoprotein release permease component
E5678_RS21605	COG1136	(ABC) transporter
E5678_RS21615	COG0084	hydrolase, TatD family'
E5678_RS21630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5678_RS21645	COG1028	Short-chain dehydrogenase reductase Sdr
E5678_RS21650	COG0697	spore germination
E5678_RS21665	COG1283	sodium-dependent phosphate transmembrane transporter activity
E5678_RS21670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E5678_RS21675	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E5678_RS21680	COG0196	riboflavin kinase activity
E5678_RS21695	COG1960	acyl-CoA dehydrogenase activity
E5678_RS21700	COG1960	acyl-CoA dehydrogenase activity
E5678_RS21705	COG3132	Protein of unknown function, DUF480
E5678_RS21710	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E5678_RS21715	COG1238	metal cluster binding
E5678_RS21720	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E5678_RS21725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5678_RS21725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5678_RS21735	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E5678_RS21740	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E5678_RS21745	COG0492	ferredoxin-NADP+ reductase activity
E5678_RS21755	COG1674	ftsk spoiiie
E5678_RS21760	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E5678_RS21765	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5678_RS21770	COG0559	Belongs to the binding-protein-dependent transport system permease family
E5678_RS21790	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E5678_RS21795	COG1408	metallophosphoesterase
E5678_RS21815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E5678_RS21820	COG0724	RNA recognition motif
E5678_RS21825	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E5678_RS21830	COG0830	nickel cation binding
E5678_RS21835	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
E5678_RS21840	COG0804	urea catabolic process
E5678_RS21845	COG0832	Belongs to the urease beta subunit family
E5678_RS21850	COG0831	urea catabolic process
E5678_RS21855	COG2205	protein histidine kinase activity
E5678_RS21855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5678_RS21865	COG0583	DNA-binding transcription factor activity
E5678_RS21870	COG0697	spore germination
E5678_RS21880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5678_RS21890	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E5678_RS21925	COG2207	Transcriptional regulator
E5678_RS21935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5678_RS21940	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E5678_RS21965	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E5678_RS21985	COG3626	phosphonate metabolism
E5678_RS21990	COG3627	carbon phosphorus lyase activity
E5678_RS22000	COG4107	phosphonate C-P lyase system protein PhnK
E5678_RS22005	COG4778	phosphonate C-P lyase system protein PhnL
E5678_RS22010	COG3454	Phosphonate metabolism
E5678_RS22015	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E5678_RS22020	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E5678_RS22025	COG3639	organic phosphonate transmembrane transporter activity
E5678_RS22040	COG1230	cation diffusion facilitator family transporter
E5678_RS22060	COG0701	Predicted permease
E5678_RS22070	COG0798	PFAM Bile acid sodium symporter
E5678_RS22085	COG0640	Transcriptional regulator
E5678_RS22125	COG0829	nickel cation binding
E5678_RS22135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5678_RS22140	COG1116	anion transmembrane transporter activity
E5678_RS22155	COG0719	Fe-S assembly protein
E5678_RS22160	COG0396	ATPase activity
E5678_RS22170	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E5678_RS22180	COG2151	metal-sulfur cluster biosynthetic enzyme
E5678_RS22185	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions