locus-tag	class	description
GHNINEIG_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GHNINEIG_RS00010	COG0592	DNA-directed DNA polymerase activity
GHNINEIG_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GHNINEIG_RS00050	COG0697	spore germination
GHNINEIG_RS00065	COG0187	DNA topoisomerase II activity
GHNINEIG_RS00090	COG0408	coproporphyrinogen oxidase activity
GHNINEIG_RS00100	COG0009	L-threonylcarbamoyladenylate synthase
GHNINEIG_RS00110	COG3706	GGDEF domain
GHNINEIG_RS00120	COG1280	lysine exporter protein (LysE YggA)
GHNINEIG_RS00125	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GHNINEIG_RS00150	COG2200	EAL domain
GHNINEIG_RS00165	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
GHNINEIG_RS00180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GHNINEIG_RS00185	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GHNINEIG_RS00185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GHNINEIG_RS00200	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GHNINEIG_RS00205	COG1333	cytochrome c biogenesis protein
GHNINEIG_RS00210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GHNINEIG_RS00220	COG0028	Belongs to the TPP enzyme family
GHNINEIG_RS00230	COG0778	Nitroreductase
GHNINEIG_RS00245	COG1320	monovalent cation:proton antiporter activity
GHNINEIG_RS00250	COG2212	antiporter activity
GHNINEIG_RS00255	COG1863	multisubunit Na H antiporter MnhE subunit
GHNINEIG_RS00260	COG0651	ATP synthesis coupled electron transport
GHNINEIG_RS00265	COG1006	Multisubunit Na H antiporter MnhC subunit
GHNINEIG_RS00270	COG2111	Na H antiporter
GHNINEIG_RS00270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GHNINEIG_RS00275	COG1283	sodium-dependent phosphate transmembrane transporter activity
GHNINEIG_RS00290	COG0432	Pfam Uncharacterised protein family UPF0047
GHNINEIG_RS00295	COG3850	Histidine kinase
GHNINEIG_RS00295	COG3437	response regulator, receiver
GHNINEIG_RS00295	COG4999	Histidine kinase
GHNINEIG_RS00295	COG2205	protein histidine kinase activity
GHNINEIG_RS00300	COG0339	signal peptide processing
GHNINEIG_RS00310	COG2814	Major facilitator Superfamily
GHNINEIG_RS00325	COG2304	oxidoreductase activity
GHNINEIG_RS00345	COG0714	Associated with various cellular activities
GHNINEIG_RS00350	COG0840	transmembrane signaling receptor activity
GHNINEIG_RS00355	COG0500	methyltransferase
GHNINEIG_RS00360	COG2226	methyltransferase
GHNINEIG_RS00375	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GHNINEIG_RS00380	COG2199	diguanylate cyclase activity
GHNINEIG_RS00390	COG0640	Transcriptional regulator
GHNINEIG_RS00395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GHNINEIG_RS00395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GHNINEIG_RS00405	COG0714	Associated with various cellular activities
GHNINEIG_RS00440	COG3118	belongs to the thioredoxin family
GHNINEIG_RS00460	COG3266	domain, Protein
GHNINEIG_RS00460	COG0515	serine threonine protein kinase
GHNINEIG_RS00470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GHNINEIG_RS00480	COG0165	Argininosuccinate lyase
GHNINEIG_RS00490	COG0181	hydroxymethylbilane synthase activity
GHNINEIG_RS00520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GHNINEIG_RS00525	COG0857	belongs to the CobB CobQ family
GHNINEIG_RS00525	COG0280	phosphate acetyltransferase
GHNINEIG_RS00530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GHNINEIG_RS00540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GHNINEIG_RS00545	COG1194	a g-specific adenine glycosylase
GHNINEIG_RS00550	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GHNINEIG_RS00555	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GHNINEIG_RS00560	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GHNINEIG_RS00570	COG0254	rRNA binding
GHNINEIG_RS00575	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GHNINEIG_RS00585	COG0210	DNA helicase
GHNINEIG_RS00590	COG1136	(ABC) transporter
GHNINEIG_RS00595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GHNINEIG_RS00595	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GHNINEIG_RS00610	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GHNINEIG_RS00615	COG1234	tRNA 3'-trailer cleavage
GHNINEIG_RS00620	COG2205	protein histidine kinase activity
GHNINEIG_RS00620	COG0784	Response regulator, receiver
GHNINEIG_RS00620	COG5002	protein histidine kinase activity
GHNINEIG_RS00630	COG2081	HI0933 family
GHNINEIG_RS00640	COG0678	peroxiredoxin activity
GHNINEIG_RS00640	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GHNINEIG_RS00660	COG0351	phosphomethylpyrimidine kinase
GHNINEIG_RS00670	COG2022	thiamine diphosphate biosynthetic process
GHNINEIG_RS00685	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GHNINEIG_RS00700	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GHNINEIG_RS00710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GHNINEIG_RS00735	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GHNINEIG_RS00740	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GHNINEIG_RS00745	COG0314	molybdopterin synthase activity
GHNINEIG_RS00750	COG0303	'Molybdopterin
GHNINEIG_RS00755	COG0315	cyclic pyranopterin monophosphate synthase activity
GHNINEIG_RS00780	COG1490	D-aminoacyl-tRNA deacylase activity
GHNINEIG_RS00790	COG1217	gtp-binding protein TYPA
GHNINEIG_RS00805	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GHNINEIG_RS00815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GHNINEIG_RS00820	COG0730	response to heat
GHNINEIG_RS00835	COG1528	Iron-storage protein
GHNINEIG_RS00845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GHNINEIG_RS00850	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GHNINEIG_RS00855	COG2258	MOSC domain
GHNINEIG_RS00860	COG0037	tRNA processing
GHNINEIG_RS00865	COG1560	Kdo2-lipid A biosynthetic process
GHNINEIG_RS00880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GHNINEIG_RS00885	COG0569	domain protein
GHNINEIG_RS00890	COG2204	response regulator
GHNINEIG_RS00895	COG5000	phosphorelay sensor kinase activity
GHNINEIG_RS00905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GHNINEIG_RS00905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GHNINEIG_RS00910	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GHNINEIG_RS00915	COG0242	peptide deformylase activity
GHNINEIG_RS00920	COG0758	DNA mediated transformation
GHNINEIG_RS00925	COG0745	RESPONSE REGULATOR receiver
GHNINEIG_RS00935	COG5001	Diguanylate cyclase
GHNINEIG_RS00940	COG0018	arginyl-trna synthetase
GHNINEIG_RS00950	COG2199	diguanylate cyclase activity
GHNINEIG_RS01060	COG2197	response regulator
GHNINEIG_RS01065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GHNINEIG_RS01075	COG3706	GGDEF domain
GHNINEIG_RS01085	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GHNINEIG_RS01085	COG2885	chlorophyll binding
GHNINEIG_RS01090	COG1454	alcohol dehydrogenase
GHNINEIG_RS01100	COG2813	Specifically methylates the guanine in position
GHNINEIG_RS01115	COG0585	pseudouridine synthase activity
GHNINEIG_RS01120	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GHNINEIG_RS01130	COG1473	amidohydrolase
GHNINEIG_RS01135	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GHNINEIG_RS01140	COG0006	proline dipeptidase activity
GHNINEIG_RS01145	COG1012	belongs to the aldehyde dehydrogenase family
GHNINEIG_RS01165	COG4191	Histidine kinase
GHNINEIG_RS01165	COG0784	Response regulator, receiver
GHNINEIG_RS01170	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GHNINEIG_RS01210	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GHNINEIG_RS01215	COG3100	YcgL domain-containing protein
GHNINEIG_RS01225	COG0617	tRNA 3'-terminal CCA addition
GHNINEIG_RS01230	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GHNINEIG_RS01245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GHNINEIG_RS01250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GHNINEIG_RS01255	COG0126	phosphoglycerate kinase activity
GHNINEIG_RS01265	COG0191	fructose-bisphosphate aldolase activity
GHNINEIG_RS01280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GHNINEIG_RS01315	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GHNINEIG_RS01330	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GHNINEIG_RS01335	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GHNINEIG_RS01345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GHNINEIG_RS01350	COG0546	phosphoglycolate phosphatase activity
GHNINEIG_RS01355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GHNINEIG_RS01360	COG0512	Glutamine amidotransferase of anthranilate synthase
GHNINEIG_RS01365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GHNINEIG_RS01370	COG0134	indole-3-glycerol-phosphate synthase activity
GHNINEIG_RS01385	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GHNINEIG_RS01390	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GHNINEIG_RS01395	COG0019	diaminopimelate decarboxylase activity
GHNINEIG_RS01400	COG1765	OsmC-like protein
GHNINEIG_RS01420	COG0564	pseudouridine synthase activity
GHNINEIG_RS01445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GHNINEIG_RS01455	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GHNINEIG_RS01465	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GHNINEIG_RS01470	COG0081	regulation of translation
GHNINEIG_RS01475	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GHNINEIG_RS01480	COG0222	ribosome binding
GHNINEIG_RS01485	COG0085	RNA polymerase activity
GHNINEIG_RS01490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GHNINEIG_RS01495	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GHNINEIG_RS01500	COG0049	tRNA binding
GHNINEIG_RS01505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GHNINEIG_RS01510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GHNINEIG_RS01515	COG0051	transcription antitermination factor activity, RNA binding
GHNINEIG_RS01520	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GHNINEIG_RS01525	COG0088	Forms part of the polypeptide exit tunnel
GHNINEIG_RS01530	COG0089	rRNA binding
GHNINEIG_RS01535	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GHNINEIG_RS01540	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GHNINEIG_RS01545	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GHNINEIG_RS01550	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GHNINEIG_RS01555	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GHNINEIG_RS01560	COG0255	Belongs to the universal ribosomal protein uL29 family
GHNINEIG_RS01565	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GHNINEIG_RS01570	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GHNINEIG_RS01575	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GHNINEIG_RS01580	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GHNINEIG_RS01585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GHNINEIG_RS01590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GHNINEIG_RS01595	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GHNINEIG_RS01600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GHNINEIG_RS01605	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GHNINEIG_RS01610	COG1841	ribosomal large subunit assembly
GHNINEIG_RS01615	COG0200	Binds to the 23S rRNA
GHNINEIG_RS01620	COG0201	protein transport
GHNINEIG_RS01625	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GHNINEIG_RS01630	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GHNINEIG_RS01635	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GHNINEIG_RS01640	COG0202	RNA polymerase activity
GHNINEIG_RS01645	COG0203	ribosomal protein L17
GHNINEIG_RS01655	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GHNINEIG_RS01675	COG2814	Major facilitator Superfamily
GHNINEIG_RS01710	COG0142	geranyltranstransferase activity
GHNINEIG_RS01715	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GHNINEIG_RS01720	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GHNINEIG_RS01725	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GHNINEIG_RS01730	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GHNINEIG_RS01735	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GHNINEIG_RS01740	COG0459	protein refolding
GHNINEIG_RS01750	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GHNINEIG_RS01755	COG0316	Belongs to the HesB IscA family
GHNINEIG_RS01765	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GHNINEIG_RS01770	COG0739	heme binding
GHNINEIG_RS01775	COG0425	Belongs to the sulfur carrier protein TusA family
GHNINEIG_RS01775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GHNINEIG_RS01785	COG0751	glycine-tRNA ligase activity
GHNINEIG_RS01790	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GHNINEIG_RS01815	COG0840	transmembrane signaling receptor activity
GHNINEIG_RS01820	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GHNINEIG_RS01825	COG0259	pyridoxamine-phosphate oxidase activity
GHNINEIG_RS01835	COG3706	GGDEF domain
GHNINEIG_RS01860	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GHNINEIG_RS01865	COG1360	Flagellar Motor Protein
GHNINEIG_RS01870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GHNINEIG_RS01875	COG2890	protein-(glutamine-N5) methyltransferase activity
GHNINEIG_RS01880	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GHNINEIG_RS01885	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GHNINEIG_RS01900	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GHNINEIG_RS01905	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GHNINEIG_RS01910	COG0193	aminoacyl-tRNA hydrolase activity
GHNINEIG_RS01930	COG3328	transposase activity
GHNINEIG_RS01980	COG2856	Zn peptidase
GHNINEIG_RS02005	COG2252	PERMEase
GHNINEIG_RS02010	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GHNINEIG_RS02020	COG2226	methyltransferase
GHNINEIG_RS02030	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GHNINEIG_RS02035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GHNINEIG_RS02060	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GHNINEIG_RS02080	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GHNINEIG_RS02085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GHNINEIG_RS02095	COG0542	response to heat
GHNINEIG_RS02135	COG0288	reversible hydration of carbon dioxide
GHNINEIG_RS02150	COG1850	ribulose-bisphosphate carboxylase activity
GHNINEIG_RS02155	COG0583	DNA-binding transcription factor activity
GHNINEIG_RS02165	COG1850	ribulose-bisphosphate carboxylase activity
GHNINEIG_RS02180	COG4548	von Willebrand factor, type A
GHNINEIG_RS02195	COG1136	(ABC) transporter
GHNINEIG_RS02225	COG0138	bifunctional purine biosynthesis protein purh
GHNINEIG_RS02230	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GHNINEIG_RS02240	COG2264	protein methyltransferase activity
GHNINEIG_RS02245	COG0439	Biotin carboxylase
GHNINEIG_RS02250	COG0511	ligase activity, forming carbon-carbon bonds
GHNINEIG_RS02255	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GHNINEIG_RS02260	COG4232	protein-disulfide reductase activity
GHNINEIG_RS02265	COG3030	protein affecting phage T7 exclusion by the F plasmid
GHNINEIG_RS02280	COG3439	Domain of unknown function DUF302
GHNINEIG_RS02285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GHNINEIG_RS02310	COG0523	cobalamin synthesis protein
GHNINEIG_RS02330	COG2005	Transcriptional regulator
GHNINEIG_RS02335	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GHNINEIG_RS02340	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GHNINEIG_RS02345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GHNINEIG_RS02365	COG0829	nickel cation binding
GHNINEIG_RS02370	COG0831	urea catabolic process
GHNINEIG_RS02375	COG0832	Belongs to the urease beta subunit family
GHNINEIG_RS02380	COG0804	urea catabolic process
GHNINEIG_RS02385	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
GHNINEIG_RS02390	COG0830	nickel cation binding
GHNINEIG_RS02395	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GHNINEIG_RS02405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GHNINEIG_RS02470	COG5002	protein histidine kinase activity
GHNINEIG_RS02480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GHNINEIG_RS02485	COG1702	phosphate starvation-inducible protein PhoH
GHNINEIG_RS02490	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GHNINEIG_RS02495	COG4535	Mg2 and Co2 transporter CorC
GHNINEIG_RS02500	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GHNINEIG_RS02510	COG0495	leucyl-tRNA aminoacylation
GHNINEIG_RS02525	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GHNINEIG_RS02535	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GHNINEIG_RS02540	COG0799	negative regulation of ribosome biogenesis
GHNINEIG_RS02545	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GHNINEIG_RS02575	COG0268	Binds directly to 16S ribosomal RNA
GHNINEIG_RS02585	COG0196	riboflavin kinase activity
GHNINEIG_RS02590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GHNINEIG_RS02595	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GHNINEIG_RS02605	COG2951	lytic endotransglycosylase activity
GHNINEIG_RS02610	COG0116	Belongs to the methyltransferase superfamily
GHNINEIG_RS02610	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GHNINEIG_RS02615	COG3706	GGDEF domain
GHNINEIG_RS02625	COG1519	Transferase
GHNINEIG_RS02630	COG0517	IMP dehydrogenase activity
GHNINEIG_RS02630	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GHNINEIG_RS02640	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GHNINEIG_RS02640	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GHNINEIG_RS02645	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GHNINEIG_RS02650	COG0837	glucose binding
GHNINEIG_RS02655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GHNINEIG_RS02670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GHNINEIG_RS02675	COG0297	glycogen (starch) synthase activity
GHNINEIG_RS02680	COG0058	SHG alpha-glucan phosphorylase activity
GHNINEIG_RS02690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GHNINEIG_RS02705	COG0456	acetyltransferase
GHNINEIG_RS02710	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GHNINEIG_RS02715	COG1917	Cupin 2, conserved barrel domain protein
GHNINEIG_RS02720	COG0527	aspartate kinase activity
GHNINEIG_RS02750	COG1902	pentaerythritol trinitrate reductase activity
GHNINEIG_RS02760	COG3706	GGDEF domain
GHNINEIG_RS02780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GHNINEIG_RS02785	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GHNINEIG_RS02790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GHNINEIG_RS02795	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GHNINEIG_RS02800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GHNINEIG_RS02815	COG0174	glutamine synthetase
GHNINEIG_RS02825	COG0573	inorganic phosphate transmembrane transporter activity
GHNINEIG_RS02830	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GHNINEIG_RS02850	COG0306	phosphate transporter
GHNINEIG_RS02885	COG4181	ATPase activity
GHNINEIG_RS02890	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GHNINEIG_RS02905	COG3328	transposase activity
GHNINEIG_RS02915	COG1643	Atp-dependent helicase
GHNINEIG_RS02945	COG2001	Belongs to the MraZ family
GHNINEIG_RS02950	COG0275	rRNA processing
GHNINEIG_RS02975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GHNINEIG_RS02980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GHNINEIG_RS02985	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GHNINEIG_RS02990	COG0772	Belongs to the SEDS family
GHNINEIG_RS02995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GHNINEIG_RS03010	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GHNINEIG_RS03015	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GHNINEIG_RS03030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GHNINEIG_RS03035	COG1121	(ABC) transporter
GHNINEIG_RS03040	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GHNINEIG_RS03050	COG0719	Fe-S assembly protein
GHNINEIG_RS03055	COG0396	ATPase activity
GHNINEIG_RS03060	COG0719	Fe-S assembly protein
GHNINEIG_RS03065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GHNINEIG_RS03075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GHNINEIG_RS03080	COG1181	Belongs to the D-alanine--D-alanine ligase family
GHNINEIG_RS03085	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GHNINEIG_RS03095	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GHNINEIG_RS03100	COG0653	protein targeting
GHNINEIG_RS03110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GHNINEIG_RS03115	COG0494	nUDIX hydrolase
GHNINEIG_RS03125	COG0237	dephospho-CoA kinase activity
GHNINEIG_RS03130	COG0367	asparagine synthase
GHNINEIG_RS03140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GHNINEIG_RS03145	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GHNINEIG_RS03145	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GHNINEIG_RS03150	COG0129	dihydroxy-acid dehydratase activity
GHNINEIG_RS03160	COG3258	Cytochrome c
GHNINEIG_RS03180	COG4783	chaperone-mediated protein folding
GHNINEIG_RS03185	COG0425	Belongs to the sulfur carrier protein TusA family
GHNINEIG_RS03190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GHNINEIG_RS03195	COG0166	Belongs to the GPI family
GHNINEIG_RS03205	COG1183	phosphatidylcholine synthase activity
GHNINEIG_RS03210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GHNINEIG_RS03220	COG1214	PFAM Peptidase M22, glycoprotease
GHNINEIG_RS03220	COG0456	acetyltransferase
GHNINEIG_RS03240	COG1959	2 iron, 2 sulfur cluster binding
GHNINEIG_RS03245	COG0316	Belongs to the HesB IscA family
GHNINEIG_RS03255	COG0105	UTP biosynthetic process
GHNINEIG_RS03260	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GHNINEIG_RS03270	COG0124	histidyl-tRNA synthetase
GHNINEIG_RS03280	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GHNINEIG_RS03285	COG1160	GTP binding
GHNINEIG_RS03290	COG0277	FAD linked oxidase domain protein
GHNINEIG_RS03290	COG0247	lactate metabolic process
GHNINEIG_RS03295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GHNINEIG_RS03315	COG1162	GTPase activity
GHNINEIG_RS03320	COG2154	pterin-4-alpha-carbinolamine dehydratase
GHNINEIG_RS03325	COG0501	Belongs to the peptidase M48B family
GHNINEIG_RS03330	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GHNINEIG_RS03335	COG0028	Belongs to the TPP enzyme family
GHNINEIG_RS03345	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GHNINEIG_RS03370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GHNINEIG_RS03375	COG1459	type II secretion system
GHNINEIG_RS03395	COG1322	Protein conserved in bacteria
GHNINEIG_RS03400	COG0228	four-way junction DNA binding
GHNINEIG_RS03405	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GHNINEIG_RS03410	COG0336	Belongs to the RNA methyltransferase TrmD family
GHNINEIG_RS03415	COG0335	large ribosomal subunit rRNA binding
GHNINEIG_RS03420	COG4974	Belongs to the 'phage' integrase family
GHNINEIG_RS03425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GHNINEIG_RS03440	COG0564	pseudouridine synthase activity
GHNINEIG_RS03445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GHNINEIG_RS03450	COG1530	ribonuclease E activity
GHNINEIG_RS03455	COG0564	pseudouridine synthase activity
GHNINEIG_RS03460	COG0546	phosphoglycolate phosphatase activity
GHNINEIG_RS03465	COG0424	maF-like protein
GHNINEIG_RS03475	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GHNINEIG_RS03480	COG0416	fatty acid biosynthetic process
GHNINEIG_RS03485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GHNINEIG_RS03500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GHNINEIG_RS03505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GHNINEIG_RS03510	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GHNINEIG_RS03520	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GHNINEIG_RS03525	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GHNINEIG_RS03535	COG0084	hydrolase, TatD family'
GHNINEIG_RS03540	COG1132	(ABC) transporter
GHNINEIG_RS03545	COG0840	transmembrane signaling receptor activity
GHNINEIG_RS03550	COG2217	Heavy metal translocating P-type atpase
GHNINEIG_RS03570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GHNINEIG_RS03585	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GHNINEIG_RS03590	COG0354	folic acid binding
GHNINEIG_RS03595	COG0835	chemotaxis
GHNINEIG_RS03600	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GHNINEIG_RS03610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GHNINEIG_RS03615	COG0481	GTPase activity
GHNINEIG_RS03630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GHNINEIG_RS03635	COG1381	Involved in DNA repair and RecF pathway recombination
GHNINEIG_RS03640	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GHNINEIG_RS03645	COG0736	holo-[acyl-carrier-protein] synthase activity
GHNINEIG_RS03670	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GHNINEIG_RS03700	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GHNINEIG_RS03705	COG2198	Histidine kinase
GHNINEIG_RS03705	COG0643	Histidine kinase
GHNINEIG_RS03705	COG0784	Response regulator, receiver
GHNINEIG_RS03710	COG0835	chemotaxis
GHNINEIG_RS03725	COG0745	RESPONSE REGULATOR receiver
GHNINEIG_RS03730	COG0835	chemotaxis
GHNINEIG_RS03740	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GHNINEIG_RS03745	COG2201	protein-glutamate methylesterase activity
GHNINEIG_RS03760	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GHNINEIG_RS03760	COG3323	Protein of unknown function (DUF1653)
GHNINEIG_RS03765	COG0545	Peptidyl-prolyl cis-trans isomerase
GHNINEIG_RS03770	COG0492	ferredoxin-NADP+ reductase activity
GHNINEIG_RS03780	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GHNINEIG_RS03785	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GHNINEIG_RS03790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GHNINEIG_RS03795	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GHNINEIG_RS03805	COG0582	viral genome integration into host DNA
GHNINEIG_RS03810	COG3328	transposase activity
GHNINEIG_RS03840	COG3177	Filamentation induced by cAMP protein fic
GHNINEIG_RS03845	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GHNINEIG_RS03860	COG3328	transposase activity
GHNINEIG_RS03930	COG3118	belongs to the thioredoxin family
GHNINEIG_RS03950	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GHNINEIG_RS03970	COG1773	rubredoxin
GHNINEIG_RS04000	COG2204	response regulator
GHNINEIG_RS04010	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GHNINEIG_RS04065	COG3328	transposase activity
GHNINEIG_RS04120	COG2200	EAL domain
GHNINEIG_RS04120	COG2199	diguanylate cyclase activity
GHNINEIG_RS04130	COG3769	mannosylglycerate metabolic process
GHNINEIG_RS04135	COG1215	transferase activity, transferring glycosyl groups
GHNINEIG_RS04145	COG1929	Belongs to the glycerate kinase type-1 family
GHNINEIG_RS04150	COG5002	protein histidine kinase activity
GHNINEIG_RS04150	COG5001	Diguanylate cyclase
GHNINEIG_RS04155	COG0840	transmembrane signaling receptor activity
GHNINEIG_RS04165	COG0513	Belongs to the DEAD box helicase family
GHNINEIG_RS04170	COG2353	YceI-like domain
GHNINEIG_RS04175	COG3038	cytochrome b561
GHNINEIG_RS04180	COG1090	epimerase
GHNINEIG_RS04185	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GHNINEIG_RS04190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GHNINEIG_RS04195	COG3706	GGDEF domain
GHNINEIG_RS04200	COG1959	2 iron, 2 sulfur cluster binding
GHNINEIG_RS04210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GHNINEIG_RS04210	COG1017	nitric oxide dioxygenase activity
GHNINEIG_RS04215	COG1959	2 iron, 2 sulfur cluster binding
GHNINEIG_RS04225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GHNINEIG_RS04250	COG0602	queuosine metabolic process
GHNINEIG_RS04255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GHNINEIG_RS04260	COG0066	3-isopropylmalate dehydratase activity
GHNINEIG_RS04265	COG0473	3-isopropylmalate dehydrogenase activity
GHNINEIG_RS04270	COG0739	heme binding
GHNINEIG_RS04280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GHNINEIG_RS04285	COG0101	tRNA pseudouridine synthase activity
GHNINEIG_RS04290	COG0135	phosphoribosylanthranilate isomerase activity
GHNINEIG_RS04300	COG0159	tryptophan synthase activity
GHNINEIG_RS04305	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GHNINEIG_RS04310	COG0285	dihydrofolate synthase activity
GHNINEIG_RS04330	COG1534	Rna-binding protein
GHNINEIG_RS04335	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GHNINEIG_RS04345	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GHNINEIG_RS04350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GHNINEIG_RS04355	COG0149	triose-phosphate isomerase activity
GHNINEIG_RS04370	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GHNINEIG_RS04375	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GHNINEIG_RS04380	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GHNINEIG_RS04385	COG0649	NAD binding
GHNINEIG_RS04390	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GHNINEIG_RS04400	COG1034	ATP synthesis coupled electron transport
GHNINEIG_RS04405	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GHNINEIG_RS04410	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GHNINEIG_RS04420	COG0713	ATP synthesis coupled electron transport
GHNINEIG_RS04435	COG1007	ATP synthesis coupled electron transport
GHNINEIG_RS04455	COG1850	ribulose-bisphosphate carboxylase activity
GHNINEIG_RS04485	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GHNINEIG_RS04490	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GHNINEIG_RS04495	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GHNINEIG_RS04505	COG2154	pterin-4-alpha-carbinolamine dehydratase
GHNINEIG_RS04525	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GHNINEIG_RS04530	COG0583	DNA-binding transcription factor activity
GHNINEIG_RS04535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GHNINEIG_RS04540	COG3002	Belongs to the UPF0753 family
GHNINEIG_RS04545	COG0123	including yeast histone deacetylase and acetoin utilization protein
GHNINEIG_RS04565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GHNINEIG_RS04570	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GHNINEIG_RS04575	COG3706	GGDEF domain
GHNINEIG_RS04600	COG0497	DNA recombination
GHNINEIG_RS04605	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GHNINEIG_RS04610	COG1420	regulation of RNA biosynthetic process
GHNINEIG_RS04615	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GHNINEIG_RS04620	COG0443	Heat shock 70 kDa protein
GHNINEIG_RS04625	COG0484	heat shock protein binding
GHNINEIG_RS04630	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GHNINEIG_RS04655	COG0505	Belongs to the CarA family
GHNINEIG_RS04665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GHNINEIG_RS04680	COG2833	Protein of unknown function (DUF455)
GHNINEIG_RS04685	COG2226	methyltransferase
GHNINEIG_RS04690	COG1940	carbohydrate kinase activity
GHNINEIG_RS04700	COG1752	Esterase of the alpha-beta hydrolase superfamily
GHNINEIG_RS04705	COG0300	oxidoreductase activity
GHNINEIG_RS04715	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GHNINEIG_RS04720	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GHNINEIG_RS04725	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GHNINEIG_RS04730	COG0632	four-way junction helicase activity
GHNINEIG_RS04735	COG2255	four-way junction helicase activity
GHNINEIG_RS04745	COG0848	biopolymer transport protein
GHNINEIG_RS04755	COG0823	Involved in the tonB-independent uptake of proteins
GHNINEIG_RS04760	COG2885	chlorophyll binding
GHNINEIG_RS04770	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GHNINEIG_RS04800	COG3852	Histidine kinase
GHNINEIG_RS04840	COG0688	phosphatidylethanolamine metabolic process
GHNINEIG_RS04845	COG0137	argininosuccinate synthase activity
GHNINEIG_RS04850	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GHNINEIG_RS04860	COG1301	dicarboxylic acid transport
GHNINEIG_RS04870	COG1230	cation diffusion facilitator family transporter
GHNINEIG_RS04875	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GHNINEIG_RS04880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GHNINEIG_RS04890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GHNINEIG_RS04895	COG0215	cysteine-tRNA ligase activity
GHNINEIG_RS04910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GHNINEIG_RS04915	COG2226	methyltransferase
GHNINEIG_RS04920	COG0328	RNA-DNA hybrid ribonuclease activity
GHNINEIG_RS04935	COG1047	Peptidyl-prolyl cis-trans
GHNINEIG_RS04950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GHNINEIG_RS05000	COG1187	pseudouridine synthase activity
GHNINEIG_RS05010	COG1030	water channel activity
GHNINEIG_RS05015	COG0330	HflC and HflK could
GHNINEIG_RS05020	COG0513	Belongs to the DEAD box helicase family
GHNINEIG_RS05030	COG1643	Atp-dependent helicase
GHNINEIG_RS05050	COG0004	ammonium transporteR
GHNINEIG_RS05055	COG1067	ATP-dependent peptidase activity
GHNINEIG_RS05065	COG2333	competence protein COMEC
GHNINEIG_RS05065	COG0658	competence protein
GHNINEIG_RS05070	COG1663	tetraacyldisaccharide 4'-kinase activity
GHNINEIG_RS05075	COG2835	tetraacyldisaccharide 4'-kinase activity
GHNINEIG_RS05080	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GHNINEIG_RS05090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GHNINEIG_RS05095	COG4206	TonB-dependent receptor
GHNINEIG_RS05125	COG2205	protein histidine kinase activity
GHNINEIG_RS05130	COG0745	RESPONSE REGULATOR receiver
GHNINEIG_RS05135	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GHNINEIG_RS05140	COG2239	Acts as a magnesium transporter
GHNINEIG_RS05150	COG1137	ATPase activity
GHNINEIG_RS05165	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GHNINEIG_RS05180	COG1127	ABC transporter
GHNINEIG_RS05185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GHNINEIG_RS05190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GHNINEIG_RS05205	COG1131	(ABC) transporter
GHNINEIG_RS05210	COG0842	Transport permease protein
GHNINEIG_RS05220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GHNINEIG_RS05225	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GHNINEIG_RS05230	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GHNINEIG_RS05235	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GHNINEIG_RS05240	COG0723	plastoquinol--plastocyanin reductase activity
GHNINEIG_RS05245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GHNINEIG_RS05250	COG2857	Cytochrome c1
GHNINEIG_RS05255	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GHNINEIG_RS05265	COG4536	flavin adenine dinucleotide binding
GHNINEIG_RS05270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GHNINEIG_RS05275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GHNINEIG_RS05285	COG1051	belongs to the nudix hydrolase family
GHNINEIG_RS05295	COG0508	dehydrogenase complex catalyzes the overall conversion of
GHNINEIG_RS05300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GHNINEIG_RS05335	COG3530	Putative quorum-sensing-regulated virulence factor
GHNINEIG_RS05340	COG0456	acetyltransferase
GHNINEIG_RS05355	COG0655	NAD(P)H dehydrogenase (quinone) activity
GHNINEIG_RS05370	COG2199	diguanylate cyclase activity
GHNINEIG_RS05385	COG1192	Involved in chromosome partitioning
GHNINEIG_RS05400	COG3706	GGDEF domain
GHNINEIG_RS05415	COG0545	Peptidyl-prolyl cis-trans isomerase
GHNINEIG_RS05435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GHNINEIG_RS05440	COG4660	Part of a membrane complex involved in electron transport
GHNINEIG_RS05445	COG4659	FMN binding
GHNINEIG_RS05450	COG4658	electron transport chain
GHNINEIG_RS05455	COG4656	Part of a membrane complex involved in electron transport
GHNINEIG_RS05460	COG2878	Part of a membrane complex involved in electron transport
GHNINEIG_RS05465	COG4657	Part of a membrane complex involved in electron transport
GHNINEIG_RS05470	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GHNINEIG_RS05470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GHNINEIG_RS05480	COG0745	RESPONSE REGULATOR receiver
GHNINEIG_RS05485	COG3290	protein histidine kinase activity
GHNINEIG_RS05490	COG4191	Histidine kinase
GHNINEIG_RS05495	COG0489	protein tyrosine kinase activity
GHNINEIG_RS05500	COG0717	Belongs to the dCTP deaminase family
GHNINEIG_RS05510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GHNINEIG_RS05515	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GHNINEIG_RS05525	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GHNINEIG_RS05530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GHNINEIG_RS05550	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GHNINEIG_RS05555	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GHNINEIG_RS05585	COG2354	Protein conserved in bacteria
GHNINEIG_RS05595	COG3328	transposase activity
GHNINEIG_RS05615	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GHNINEIG_RS05625	COG3174	membrane
GHNINEIG_RS05640	COG3122	Protein conserved in bacteria
GHNINEIG_RS05650	COG0442	prolyl-tRNA aminoacylation
GHNINEIG_RS05655	COG1272	protein, Hemolysin III
GHNINEIG_RS05675	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GHNINEIG_RS05685	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GHNINEIG_RS05690	COG0802	atpase or kinase
GHNINEIG_RS05695	COG0860	N-Acetylmuramoyl-L-alanine amidase
GHNINEIG_RS05700	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GHNINEIG_RS05705	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GHNINEIG_RS05710	COG1923	regulation of RNA biosynthetic process
GHNINEIG_RS05715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GHNINEIG_RS05730	COG0330	HflC and HflK could
GHNINEIG_RS05735	COG0330	HflC and HflK could
GHNINEIG_RS05745	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GHNINEIG_RS05750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GHNINEIG_RS05760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GHNINEIG_RS05770	COG2915	High frequency lysogenization protein hflD homolog
GHNINEIG_RS05775	COG0482	sulfurtransferase activity
GHNINEIG_RS05780	COG1187	pseudouridine synthase activity
GHNINEIG_RS05810	COG2827	Endonuclease containing a URI domain
GHNINEIG_RS05815	COG0217	transcriptional regulatory protein
GHNINEIG_RS05835	COG3706	GGDEF domain
GHNINEIG_RS05840	COG2824	Alkylphosphonate utilization operon protein PhnA
GHNINEIG_RS05850	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GHNINEIG_RS05855	COG0542	response to heat
GHNINEIG_RS05860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GHNINEIG_RS05865	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GHNINEIG_RS05870	COG0587	DNA-directed DNA polymerase activity
GHNINEIG_RS05875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GHNINEIG_RS05880	COG3162	membrane
GHNINEIG_RS05885	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GHNINEIG_RS05900	COG0779	Required for maturation of 30S ribosomal subunits
GHNINEIG_RS05905	COG2251	uridine kinase activity
GHNINEIG_RS05905	COG0195	Participates in both transcription termination and antitermination
GHNINEIG_RS05910	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GHNINEIG_RS05915	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GHNINEIG_RS05920	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GHNINEIG_RS05935	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GHNINEIG_RS05940	COG1185	polyribonucleotide nucleotidyltransferase activity
GHNINEIG_RS05955	COG2850	peptidyl-arginine hydroxylation
GHNINEIG_RS05960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GHNINEIG_RS05965	COG1129	ABC transporter
GHNINEIG_RS05965	COG0842	Transport permease protein
GHNINEIG_RS05970	COG0842	Transport permease protein
GHNINEIG_RS05970	COG1129	ABC transporter
GHNINEIG_RS06015	COG0616	signal peptide processing
GHNINEIG_RS06020	COG0322	excinuclease ABC activity
GHNINEIG_RS06075	COG3707	response regulator
GHNINEIG_RS06080	COG1116	anion transmembrane transporter activity
GHNINEIG_RS06080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GHNINEIG_RS06085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GHNINEIG_RS06095	COG1116	anion transmembrane transporter activity
GHNINEIG_RS06100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GHNINEIG_RS06105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GHNINEIG_RS06110	COG2146	nitrite reductase [NAD(P)H] activity
GHNINEIG_RS06110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GHNINEIG_RS06115	COG0243	molybdopterin cofactor binding
GHNINEIG_RS06120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GHNINEIG_RS06120	COG1648	precorrin-2 dehydrogenase activity
GHNINEIG_RS06125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GHNINEIG_RS06130	COG0303	'Molybdopterin
GHNINEIG_RS06135	COG0746	molybdenum cofactor guanylyltransferase activity
GHNINEIG_RS06145	COG2894	cell division
GHNINEIG_RS06150	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GHNINEIG_RS06160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GHNINEIG_RS06170	COG0446	pyridine nucleotide-disulphide oxidoreductase
GHNINEIG_RS06180	COG4591	ABC-type transport system involved in lipoprotein release permease component
GHNINEIG_RS06185	COG1136	(ABC) transporter
GHNINEIG_RS06190	COG0488	(ABC) transporter
GHNINEIG_RS06200	COG0544	peptidyl-prolyl cis-trans isomerase activity
GHNINEIG_RS06205	COG0740	serine-type endopeptidase activity
GHNINEIG_RS06210	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GHNINEIG_RS06215	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GHNINEIG_RS06250	COG0747	negative chemotaxis
GHNINEIG_RS06255	COG0601	transmembrane transport
GHNINEIG_RS06260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GHNINEIG_RS06270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GHNINEIG_RS06270	COG0574	Belongs to the PEP-utilizing enzyme family
GHNINEIG_RS06290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GHNINEIG_RS06300	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GHNINEIG_RS06305	COG1605	Chorismate mutase
GHNINEIG_RS06305	COG0077	Prephenate dehydratase
GHNINEIG_RS06310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GHNINEIG_RS06315	COG0287	Prephenate dehydrogenase
GHNINEIG_RS06320	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GHNINEIG_RS06325	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GHNINEIG_RS06335	COG0776	regulation of translation
GHNINEIG_RS06345	COG0284	orotidine-5'-phosphate decarboxylase activity
GHNINEIG_RS06375	COG1393	Belongs to the ArsC family
GHNINEIG_RS06385	COG1570	exodeoxyribonuclease VII activity
GHNINEIG_RS06390	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GHNINEIG_RS06400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GHNINEIG_RS06405	COG0363	glucosamine-6-phosphate deaminase activity
GHNINEIG_RS06410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GHNINEIG_RS06415	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GHNINEIG_RS06440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GHNINEIG_RS06450	COG2900	Belongs to the SlyX family
GHNINEIG_RS06470	COG2207	Transcriptional regulator
GHNINEIG_RS06490	COG0783	Belongs to the Dps family
GHNINEIG_RS06500	COG1187	pseudouridine synthase activity
GHNINEIG_RS06505	COG1994	Peptidase M50
GHNINEIG_RS06510	COG0009	L-threonylcarbamoyladenylate synthase
GHNINEIG_RS06515	COG0613	PHP domain protein
GHNINEIG_RS06520	COG2917	probably involved in intracellular septation
GHNINEIG_RS06525	COG2350	Protein conserved in bacteria
GHNINEIG_RS06530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GHNINEIG_RS06550	COG3028	Belongs to the UPF0307 family
GHNINEIG_RS06555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GHNINEIG_RS06565	COG1070	Carbohydrate kinase
GHNINEIG_RS06570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GHNINEIG_RS06605	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GHNINEIG_RS06620	COG0436	Aminotransferase
GHNINEIG_RS06630	COG4942	peptidase
GHNINEIG_RS06635	COG1238	metal cluster binding
GHNINEIG_RS06640	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GHNINEIG_RS06645	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GHNINEIG_RS06655	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GHNINEIG_RS06660	COG0148	phosphopyruvate hydratase activity
GHNINEIG_RS06665	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GHNINEIG_RS06670	COG0504	CTP synthase activity
GHNINEIG_RS06675	COG0037	tRNA processing
GHNINEIG_RS06680	COG0825	malonyl-CoA metabolic process
GHNINEIG_RS06685	COG1944	ATP diphosphatase activity
GHNINEIG_RS06700	COG1214	PFAM Peptidase M22, glycoprotease
GHNINEIG_RS06705	COG1199	ATP-dependent helicase activity
GHNINEIG_RS06710	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GHNINEIG_RS06715	COG0784	Response regulator, receiver
GHNINEIG_RS06715	COG0835	chemotaxis
GHNINEIG_RS06720	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GHNINEIG_RS06725	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GHNINEIG_RS06730	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GHNINEIG_RS06735	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GHNINEIG_RS06740	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GHNINEIG_RS06755	COG0750	zinc metalloprotease
GHNINEIG_RS06760	COG0575	Belongs to the CDS family
GHNINEIG_RS06770	COG0233	cytoplasmic translational termination
GHNINEIG_RS06775	COG0528	UMP kinase activity
GHNINEIG_RS06780	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GHNINEIG_RS06785	COG0052	Belongs to the universal ribosomal protein uS2 family
GHNINEIG_RS06790	COG0024	Methionine aminopeptidase
GHNINEIG_RS06795	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GHNINEIG_RS06805	COG2171	N-acyltransferase activity
GHNINEIG_RS06810	COG1393	Belongs to the ArsC family
GHNINEIG_RS06815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GHNINEIG_RS06830	COG0733	neurotransmitter:sodium symporter activity
GHNINEIG_RS06835	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GHNINEIG_RS06840	COG0668	transmembrane transport
GHNINEIG_RS06845	COG1472	Belongs to the glycosyl hydrolase 3 family
GHNINEIG_RS06855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GHNINEIG_RS06860	COG0601	transmembrane transport
GHNINEIG_RS06865	COG1376	ErfK ybiS ycfS ynhG family protein
GHNINEIG_RS06875	COG3647	Membrane
GHNINEIG_RS06890	COG2954	triphosphatase activity
GHNINEIG_RS06920	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GHNINEIG_RS06925	COG0826	peptidase U32
GHNINEIG_RS06935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GHNINEIG_RS06940	COG1730	sister chromatid segregation
GHNINEIG_RS07005	COG1981	membrane
GHNINEIG_RS07010	COG1047	Peptidyl-prolyl cis-trans
GHNINEIG_RS07015	COG2983	Belongs to the UPF0260 family
GHNINEIG_RS07020	COG0564	pseudouridine synthase activity
GHNINEIG_RS07030	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GHNINEIG_RS07035	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GHNINEIG_RS07040	COG1862	Preprotein translocase
GHNINEIG_RS07045	COG0343	queuine tRNA-ribosyltransferase activity
GHNINEIG_RS07050	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GHNINEIG_RS07065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GHNINEIG_RS07070	COG1840	ABC-type Fe3 transport system, periplasmic component
GHNINEIG_RS07075	COG4149	molybdate abc transporter
GHNINEIG_RS07105	COG3012	SEC-C Motif Domain Protein
GHNINEIG_RS07110	COG0534	Mate efflux family protein
GHNINEIG_RS07135	COG0359	binds to the 23S rRNA
GHNINEIG_RS07145	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GHNINEIG_RS07150	COG0360	Binds together with S18 to 16S ribosomal RNA
GHNINEIG_RS07155	COG0716	FMN binding
GHNINEIG_RS07165	COG3023	N-Acetylmuramoyl-L-alanine amidase
GHNINEIG_RS07195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GHNINEIG_RS07195	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GHNINEIG_RS07200	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GHNINEIG_RS07205	COG0045	succinate-CoA ligase (ADP-forming) activity
GHNINEIG_RS07215	COG1047	Peptidyl-prolyl cis-trans
GHNINEIG_RS07220	COG3706	GGDEF domain
GHNINEIG_RS07245	COG2197	response regulator
GHNINEIG_RS07250	COG0784	Response regulator, receiver
GHNINEIG_RS07250	COG2205	protein histidine kinase activity
GHNINEIG_RS07260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GHNINEIG_RS07270	COG0450	alkyl hydroperoxide reductase
GHNINEIG_RS07275	COG0142	geranyltranstransferase activity
GHNINEIG_RS07280	COG0720	synthase
GHNINEIG_RS07290	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GHNINEIG_RS07300	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GHNINEIG_RS07305	COG0840	transmembrane signaling receptor activity
GHNINEIG_RS07310	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GHNINEIG_RS07315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GHNINEIG_RS07320	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GHNINEIG_RS07335	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GHNINEIG_RS07335	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GHNINEIG_RS07340	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GHNINEIG_RS07345	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GHNINEIG_RS07350	COG0488	(ABC) transporter
GHNINEIG_RS07355	COG5001	Diguanylate cyclase
GHNINEIG_RS07355	COG3300	MHYT domain
GHNINEIG_RS07360	COG0735	belongs to the Fur family
GHNINEIG_RS07380	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GHNINEIG_RS07390	COG0582	viral genome integration into host DNA
GHNINEIG_RS07395	COG3328	transposase activity
GHNINEIG_RS07430	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GHNINEIG_RS07440	COG1522	sequence-specific DNA binding
GHNINEIG_RS07460	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GHNINEIG_RS07555	COG1360	Flagellar Motor Protein
GHNINEIG_RS07560	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GHNINEIG_RS07590	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GHNINEIG_RS07600	COG1677	Flagellar hook-basal body complex protein FliE
GHNINEIG_RS07630	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GHNINEIG_RS07650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GHNINEIG_RS07660	COG1083	cytidylyl-transferase
GHNINEIG_RS07665	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GHNINEIG_RS07670	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GHNINEIG_RS07675	COG2089	acid synthase
GHNINEIG_RS07690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GHNINEIG_RS07695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GHNINEIG_RS07700	COG0741	lytic transglycosylase activity
GHNINEIG_RS07720	COG1706	bacterial-type flagellum-dependent cell motility
GHNINEIG_RS07725	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GHNINEIG_RS07735	COG4787	bacterial-type flagellum-dependent cell motility
GHNINEIG_RS07740	COG1749	Flagellar hook protein flgE
GHNINEIG_RS07745	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GHNINEIG_RS07750	COG1558	bacterial-type flagellum-dependent cell motility
GHNINEIG_RS07755	COG1815	bacterial-type flagellum-dependent cell motility
GHNINEIG_RS07765	COG0835	chemotaxis
GHNINEIG_RS07765	COG0784	Response regulator, receiver
GHNINEIG_RS07815	COG0308	aminopeptidase N
GHNINEIG_RS07820	COG2885	chlorophyll binding
GHNINEIG_RS07825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GHNINEIG_RS07840	COG0557	exoribonuclease II activity
GHNINEIG_RS07850	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GHNINEIG_RS07855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GHNINEIG_RS07855	COG0301	tRNA thio-modification
GHNINEIG_RS07865	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GHNINEIG_RS07870	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GHNINEIG_RS07890	COG0004	ammonium transporteR
GHNINEIG_RS07900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GHNINEIG_RS07905	COG0525	valine-tRNA ligase activity
GHNINEIG_RS07910	COG4991	sh3 domain protein
GHNINEIG_RS07945	COG1530	ribonuclease E activity
GHNINEIG_RS07950	COG0424	maF-like protein
GHNINEIG_RS07965	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GHNINEIG_RS07970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GHNINEIG_RS07980	COG0438	transferase activity, transferring glycosyl groups
GHNINEIG_RS07990	COG0463	Glycosyl transferase, family 2
GHNINEIG_RS07995	COG0275	rRNA processing
GHNINEIG_RS08010	COG3562	capsule polysaccharide
GHNINEIG_RS08020	COG0859	PFAM glycosyl transferase family 9
GHNINEIG_RS08025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GHNINEIG_RS08035	COG1132	(ABC) transporter
GHNINEIG_RS08040	COG1560	Kdo2-lipid A biosynthetic process
GHNINEIG_RS08045	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GHNINEIG_RS08050	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GHNINEIG_RS08060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GHNINEIG_RS08065	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GHNINEIG_RS08070	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GHNINEIG_RS08075	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GHNINEIG_RS08080	COG0617	tRNA 3'-terminal CCA addition
GHNINEIG_RS08090	COG0180	Tryptophanyl-tRNA synthetase
GHNINEIG_RS08100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GHNINEIG_RS08105	COG0659	secondary active sulfate transmembrane transporter activity
GHNINEIG_RS08110	COG3123	guanosine phosphorylase activity
GHNINEIG_RS08130	COG2873	o-acetylhomoserine
GHNINEIG_RS08140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GHNINEIG_RS08155	COG0667	Aldo Keto reductase
GHNINEIG_RS08160	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GHNINEIG_RS08175	COG3338	carbonate dehydratase activity
GHNINEIG_RS08185	COG0521	Mo-molybdopterin cofactor biosynthetic process
GHNINEIG_RS08190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GHNINEIG_RS08205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GHNINEIG_RS08205	COG0047	phosphoribosylformylglycinamidine synthase activity
GHNINEIG_RS08215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GHNINEIG_RS08220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GHNINEIG_RS08225	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GHNINEIG_RS08230	COG0583	DNA-binding transcription factor activity
GHNINEIG_RS08235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GHNINEIG_RS08240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GHNINEIG_RS08245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GHNINEIG_RS08250	COG0006	proline dipeptidase activity
GHNINEIG_RS08255	COG3079	Belongs to the UPF0149 family
GHNINEIG_RS08265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GHNINEIG_RS08295	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GHNINEIG_RS08305	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GHNINEIG_RS08310	COG3101	peptidyl-lysine hydroxylation
GHNINEIG_RS08325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GHNINEIG_RS08340	COG0668	transmembrane transport
GHNINEIG_RS08360	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GHNINEIG_RS08365	COG0527	aspartate kinase activity
GHNINEIG_RS08370	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GHNINEIG_RS08375	COG2137	regulation of response to DNA damage stimulus
GHNINEIG_RS08380	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GHNINEIG_RS08390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GHNINEIG_RS08395	COG3118	belongs to the thioredoxin family
GHNINEIG_RS08405	COG0189	ligase activity
GHNINEIG_RS08410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GHNINEIG_RS08415	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GHNINEIG_RS08435	COG0438	transferase activity, transferring glycosyl groups
GHNINEIG_RS08450	COG0488	(ABC) transporter
GHNINEIG_RS08455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GHNINEIG_RS08460	COG1404	Belongs to the peptidase S8 family
GHNINEIG_RS08465	COG0326	Molecular chaperone. Has ATPase activity
GHNINEIG_RS08480	COG2198	Histidine kinase
GHNINEIG_RS08480	COG0643	Histidine kinase
GHNINEIG_RS08485	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GHNINEIG_RS08495	COG0519	Catalyzes the synthesis of GMP from XMP
GHNINEIG_RS08495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GHNINEIG_RS08500	COG0516	GMP reductase activity
GHNINEIG_RS08500	COG0517	IMP dehydrogenase activity
GHNINEIG_RS08520	COG0560	Phosphoserine phosphatase
GHNINEIG_RS08525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GHNINEIG_RS08530	COG0811	peptide transport
GHNINEIG_RS08545	COG2166	iron-sulfur cluster assembly
GHNINEIG_RS08550	COG0501	Belongs to the peptidase M48B family
GHNINEIG_RS08555	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GHNINEIG_RS08560	COG0154	amidase activity
GHNINEIG_RS08565	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GHNINEIG_RS08570	COG1077	Cell shape determining protein MreB Mrl
GHNINEIG_RS08585	COG0768	penicillin binding
GHNINEIG_RS08590	COG0772	Belongs to the SEDS family
GHNINEIG_RS08595	COG1686	Belongs to the peptidase S11 family
GHNINEIG_RS08605	COG2921	Belongs to the UPF0250 family
GHNINEIG_RS08610	COG0321	lipoyl(octanoyl) transferase activity
GHNINEIG_RS08615	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GHNINEIG_RS08620	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GHNINEIG_RS08625	COG3022	response to hydroperoxide
GHNINEIG_RS08635	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GHNINEIG_RS08645	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GHNINEIG_RS08650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GHNINEIG_RS08660	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GHNINEIG_RS08665	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GHNINEIG_RS08680	COG0776	regulation of translation
GHNINEIG_RS08685	COG0072	phenylalanine-tRNA ligase activity
GHNINEIG_RS08685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GHNINEIG_RS08690	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GHNINEIG_RS08695	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GHNINEIG_RS08700	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GHNINEIG_RS08705	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GHNINEIG_RS08710	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GHNINEIG_RS08730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GHNINEIG_RS08755	COG1793	dna ligase
GHNINEIG_RS08760	COG1555	photosystem II stabilization
GHNINEIG_RS08795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GHNINEIG_RS08820	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GHNINEIG_RS08835	COG0438	transferase activity, transferring glycosyl groups
GHNINEIG_RS08885	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GHNINEIG_RS08895	COG0792	nuclease activity
GHNINEIG_RS08905	COG1074	ATP-dependent DNA helicase activity
GHNINEIG_RS08945	COG4335	DNA alkylation repair
GHNINEIG_RS08960	COG2814	Major facilitator Superfamily
GHNINEIG_RS08965	COG0564	pseudouridine synthase activity
GHNINEIG_RS08970	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GHNINEIG_RS08970	COG0674	pyruvate-flavodoxin oxidoreductase activity
GHNINEIG_RS08975	COG1013	pyruvate-flavodoxin oxidoreductase activity
GHNINEIG_RS08995	COG0589	response to stress
GHNINEIG_RS09005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GHNINEIG_RS09015	COG1304	FMN binding
GHNINEIG_RS09020	COG3425	synthase
GHNINEIG_RS09065	COG4964	Belongs to the GSP D family
GHNINEIG_RS09105	COG2969	positive regulation of protein catabolic process
GHNINEIG_RS09110	COG0625	glutathione transferase activity
GHNINEIG_RS09115	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GHNINEIG_RS09120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GHNINEIG_RS09125	COG1509	lysine 2,3-aminomutase activity
GHNINEIG_RS09145	COG0795	lipopolysaccharide-transporting ATPase activity
GHNINEIG_RS09150	COG0795	lipopolysaccharide-transporting ATPase activity
GHNINEIG_RS09155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GHNINEIG_RS09185	COG0556	nucleotide-excision repair
GHNINEIG_RS09190	COG0436	Aminotransferase
GHNINEIG_RS09195	COG0494	nUDIX hydrolase
GHNINEIG_RS09200	COG1011	Hydrolase
GHNINEIG_RS09205	COG0500	methyltransferase
GHNINEIG_RS09210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GHNINEIG_RS09220	COG0488	(ABC) transporter
GHNINEIG_RS09230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GHNINEIG_RS09270	COG1595	DNA-templated transcription, initiation
GHNINEIG_RS09275	COG1295	ribonuclease BN
GHNINEIG_RS09280	COG5001	Diguanylate cyclase
GHNINEIG_RS09280	COG3300	MHYT domain
GHNINEIG_RS09290	COG3220	belongs to the UPF0276 family
GHNINEIG_RS09305	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GHNINEIG_RS09325	COG0693	protein deglycase activity
GHNINEIG_RS09330	COG0793	Belongs to the peptidase S41A family
GHNINEIG_RS09335	COG0640	Transcriptional regulator
GHNINEIG_RS09340	COG3328	transposase activity
GHNINEIG_RS09390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GHNINEIG_RS09410	COG3665	Urea carboxylase-associated protein
GHNINEIG_RS09415	COG0439	Biotin carboxylase
GHNINEIG_RS09425	COG0438	transferase activity, transferring glycosyl groups
GHNINEIG_RS09430	COG0561	phosphatase activity
GHNINEIG_RS09430	COG3100	YcgL domain-containing protein
GHNINEIG_RS09435	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GHNINEIG_RS09435	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GHNINEIG_RS09455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GHNINEIG_RS09515	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GHNINEIG_RS09520	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GHNINEIG_RS09530	COG3550	peptidyl-serine autophosphorylation
GHNINEIG_RS09560	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GHNINEIG_RS09565	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GHNINEIG_RS09580	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GHNINEIG_RS09585	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GHNINEIG_RS09605	COG1968	undecaprenyl-diphosphatase activity
GHNINEIG_RS09610	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GHNINEIG_RS09610	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GHNINEIG_RS09620	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GHNINEIG_RS09625	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GHNINEIG_RS09630	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GHNINEIG_RS09635	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GHNINEIG_RS09640	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GHNINEIG_RS09650	COG0189	ligase activity
GHNINEIG_RS09660	COG1678	Uncharacterized ACR, COG1678
GHNINEIG_RS09665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GHNINEIG_RS09670	COG0540	Belongs to the ATCase OTCase family
GHNINEIG_RS09675	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GHNINEIG_RS09705	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GHNINEIG_RS09720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GHNINEIG_RS09725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GHNINEIG_RS09725	COG2813	Specifically methylates the guanine in position
GHNINEIG_RS09785	COG0509	glycine decarboxylation via glycine cleavage system
GHNINEIG_RS09800	COG1278	Cold shock
GHNINEIG_RS09810	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GHNINEIG_RS09825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GHNINEIG_RS09835	COG0701	Predicted permease
GHNINEIG_RS09850	COG0579	oxidoreductase
GHNINEIG_RS09855	COG0523	cobalamin synthesis protein
GHNINEIG_RS09860	COG1469	GTP cyclohydrolase I activity
GHNINEIG_RS09870	COG1522	sequence-specific DNA binding
GHNINEIG_RS09875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GHNINEIG_RS09890	COG0628	permease
GHNINEIG_RS09895	COG1611	Belongs to the LOG family
GHNINEIG_RS09900	COG0513	Belongs to the DEAD box helicase family
GHNINEIG_RS09905	COG1309	transcriptional regulator
GHNINEIG_RS09920	COG1012	belongs to the aldehyde dehydrogenase family
GHNINEIG_RS09925	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GHNINEIG_RS09930	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GHNINEIG_RS09935	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GHNINEIG_RS09945	COG0248	Ppx GppA phosphatase
GHNINEIG_RS09970	COG0840	transmembrane signaling receptor activity
GHNINEIG_RS09970	COG0840	transmembrane signaling receptor activity
GHNINEIG_RS09980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GHNINEIG_RS09995	COG1666	GTP binding
GHNINEIG_RS10000	COG0436	Aminotransferase
GHNINEIG_RS10010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GHNINEIG_RS10015	COG0756	dUTP diphosphatase activity
GHNINEIG_RS10030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GHNINEIG_RS10045	COG2205	protein histidine kinase activity
GHNINEIG_RS10045	COG0784	Response regulator, receiver
GHNINEIG_RS10055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GHNINEIG_RS10065	COG2003	Belongs to the UPF0758 family
GHNINEIG_RS10070	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GHNINEIG_RS10075	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GHNINEIG_RS10090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GHNINEIG_RS10100	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GHNINEIG_RS10110	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GHNINEIG_RS10135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GHNINEIG_RS10160	COG0742	ribosomal rna small subunit methyltransferase
GHNINEIG_RS10190	COG1346	cytolysis
GHNINEIG_RS10200	COG0612	Peptidase, M16
GHNINEIG_RS10205	COG0612	Peptidase, M16
GHNINEIG_RS10210	COG0552	protein localization to endoplasmic reticulum
GHNINEIG_RS10230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GHNINEIG_RS10240	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GHNINEIG_RS10275	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GHNINEIG_RS10280	COG0167	dihydroorotate dehydrogenase activity
GHNINEIG_RS10285	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GHNINEIG_RS10290	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GHNINEIG_RS10295	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GHNINEIG_RS10305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GHNINEIG_RS10310	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GHNINEIG_RS10315	COG0070	glutamate synthase
GHNINEIG_RS10315	COG0067	glutamate synthase
GHNINEIG_RS10315	COG0069	glutamate synthase activity
GHNINEIG_RS10320	COG0493	'glutamate synthase
GHNINEIG_RS10330	COG2217	Heavy metal translocating P-type atpase
GHNINEIG_RS10360	COG3278	Belongs to the heme-copper respiratory oxidase family
GHNINEIG_RS10365	COG0131	Imidazoleglycerol-phosphate dehydratase
GHNINEIG_RS10370	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GHNINEIG_RS10375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GHNINEIG_RS10380	COG0107	imidazoleglycerol-phosphate synthase activity
GHNINEIG_RS10385	COG0140	phosphoribosyl-ATP diphosphatase activity
GHNINEIG_RS10390	COG0537	adenosine 5'-monophosphoramidase activity
GHNINEIG_RS10395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GHNINEIG_RS10400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GHNINEIG_RS10410	COG1331	Highly conserved protein containing a thioredoxin domain
GHNINEIG_RS10420	COG1040	competence protein
GHNINEIG_RS10425	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GHNINEIG_RS10430	COG0156	8-amino-7-oxononanoate synthase activity
GHNINEIG_RS10435	COG0596	Alpha beta hydrolase
GHNINEIG_RS10440	COG2226	methyltransferase
GHNINEIG_RS10455	COG0840	transmembrane signaling receptor activity
GHNINEIG_RS10455	COG0840	transmembrane signaling receptor activity
GHNINEIG_RS10470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GHNINEIG_RS10480	COG0133	tryptophan synthase activity
GHNINEIG_RS10485	COG0742	ribosomal rna small subunit methyltransferase
GHNINEIG_RS10490	COG3040	lipid binding
GHNINEIG_RS10495	COG0259	pyridoxamine-phosphate oxidase activity
GHNINEIG_RS10515	COG1671	Belongs to the UPF0178 family
GHNINEIG_RS10520	COG0514	ATP-dependent DNA helicase (RecQ)
GHNINEIG_RS10525	COG0701	Predicted permease
GHNINEIG_RS10535	COG0840	transmembrane signaling receptor activity
GHNINEIG_RS10540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GHNINEIG_RS10550	COG0583	DNA-binding transcription factor activity
GHNINEIG_RS10555	COG1741	Belongs to the pirin family
GHNINEIG_RS10575	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GHNINEIG_RS10590	COG0840	transmembrane signaling receptor activity
GHNINEIG_RS10595	COG0616	signal peptide processing
GHNINEIG_RS10600	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GHNINEIG_RS10640	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GHNINEIG_RS10645	COG0390	transport system, permease component
GHNINEIG_RS10655	COG0071	Belongs to the small heat shock protein (HSP20) family
GHNINEIG_RS10675	COG1115	amino acid carrier protein
GHNINEIG_RS10685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GHNINEIG_RS10690	COG1053	succinate dehydrogenase
GHNINEIG_RS10730	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GHNINEIG_RS10740	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GHNINEIG_RS10745	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GHNINEIG_RS10755	COG0309	Hydrogenase expression formation protein (HypE)
GHNINEIG_RS10760	COG0409	Hydrogenase expression formation protein
GHNINEIG_RS10765	COG0298	carbon dioxide binding
GHNINEIG_RS10770	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GHNINEIG_RS10785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GHNINEIG_RS10790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GHNINEIG_RS10795	COG5001	Diguanylate cyclase
GHNINEIG_RS10795	COG5002	protein histidine kinase activity
GHNINEIG_RS10805	COG1444	tRNA N-acetyltransferase activity
GHNINEIG_RS10810	COG0788	formyltetrahydrofolate deformylase activity
GHNINEIG_RS10820	COG0543	2 iron, 2 sulfur cluster binding
GHNINEIG_RS10820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GHNINEIG_RS10830	COG1561	YicC-like family, N-terminal region
GHNINEIG_RS10845	COG3001	Fructosamine kinase
GHNINEIG_RS10850	COG0563	adenylate kinase activity
GHNINEIG_RS10855	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GHNINEIG_RS10860	COG2239	Acts as a magnesium transporter
GHNINEIG_RS10865	COG0189	ligase activity
GHNINEIG_RS10875	COG4067	protein conserved in archaea
GHNINEIG_RS10875	COG0189	ligase activity
GHNINEIG_RS10900	COG0784	Response regulator, receiver
GHNINEIG_RS10900	COG5002	protein histidine kinase activity
GHNINEIG_RS10900	COG2198	Histidine kinase
GHNINEIG_RS10910	COG0628	permease
GHNINEIG_RS10915	COG4572	Cation transport regulator
GHNINEIG_RS10970	COG0640	Transcriptional regulator
GHNINEIG_RS10980	COG2391	methyltransferase activity
GHNINEIG_RS10985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GHNINEIG_RS10985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GHNINEIG_RS11020	COG2217	Heavy metal translocating P-type atpase
GHNINEIG_RS11035	COG2132	Multicopper oxidase
GHNINEIG_RS11050	COG2132	Multicopper oxidase
GHNINEIG_RS11065	COG0789	Transcriptional regulator
GHNINEIG_RS11095	COG2188	Transcriptional regulator
GHNINEIG_RS11105	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GHNINEIG_RS11120	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
GHNINEIG_RS11130	COG3627	carbon phosphorus lyase activity
GHNINEIG_RS11135	COG4107	phosphonate C-P lyase system protein PhnK
GHNINEIG_RS11140	COG4778	phosphonate C-P lyase system protein PhnL
GHNINEIG_RS11145	COG3454	Phosphonate metabolism
GHNINEIG_RS11150	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
GHNINEIG_RS11155	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GHNINEIG_RS11210	COG0582	viral genome integration into host DNA
GHNINEIG_RS11245	COG0300	oxidoreductase activity
GHNINEIG_RS11260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GHNINEIG_RS11270	COG0415	Belongs to the DNA photolyase family
GHNINEIG_RS11280	COG1366	Belongs to the anti-sigma-factor antagonist family
GHNINEIG_RS11290	COG1854	S-ribosylhomocysteine lyase activity
GHNINEIG_RS11295	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GHNINEIG_RS11305	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GHNINEIG_RS11325	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GHNINEIG_RS11330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GHNINEIG_RS11335	COG0194	GDP metabolic process
GHNINEIG_RS11340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GHNINEIG_RS11345	COG1454	alcohol dehydrogenase
GHNINEIG_RS11350	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GHNINEIG_RS11360	COG1758	RNA polymerase activity
GHNINEIG_RS11365	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GHNINEIG_RS11375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GHNINEIG_RS11380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GHNINEIG_RS11380	COG1321	iron dependent repressor
GHNINEIG_RS11385	COG1121	(ABC) transporter
GHNINEIG_RS11390	COG0803	Belongs to the bacterial solute-binding protein 9 family
GHNINEIG_RS11400	COG0004	ammonium transporteR
GHNINEIG_RS11410	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GHNINEIG_RS11415	COG3161	chorismate lyase activity
GHNINEIG_RS11425	COG1595	DNA-templated transcription, initiation
GHNINEIG_RS11450	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GHNINEIG_RS11460	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GHNINEIG_RS11465	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GHNINEIG_RS11470	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GHNINEIG_RS11475	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GHNINEIG_RS11480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GHNINEIG_RS11485	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GHNINEIG_RS11490	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GHNINEIG_RS11495	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GHNINEIG_RS11500	COG0356	it plays a direct role in the translocation of protons across the membrane
GHNINEIG_RS11520	COG1192	Involved in chromosome partitioning
GHNINEIG_RS11525	COG0357	Ribosomal RNA small subunit methyltransferase G
GHNINEIG_RS11530	COG0445	tRNA wobble uridine modification
GHNINEIG_RS11540	COG3437	response regulator, receiver
GHNINEIG_RS11555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GHNINEIG_RS11560	COG0583	DNA-binding transcription factor activity
GHNINEIG_RS11570	COG2204	response regulator
GHNINEIG_RS11580	COG2205	protein histidine kinase activity
GHNINEIG_RS11590	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GHNINEIG_RS11590	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GHNINEIG_RS11600	COG1739	Uncharacterized protein family UPF0029
GHNINEIG_RS11610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GHNINEIG_RS11615	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GHNINEIG_RS11625	COG0706	membrane insertase activity
GHNINEIG_RS11630	COG0594	ribonuclease P activity
GHNINEIG_RS11635	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GHNINEIG_RS11645	COG0730	response to heat